Podcasts about Gerstein

Daniel M. Gerstein is a senior policy researcher at RAND and a professor of policy analysis at Pardee RAND Graduate School. Previously, he served at the U.S. Department of Homeland Security (DHS) as under secretary (acting) and deputy under secretary in the Science & Technology Directorate. Emerging Technology and risk Assessment: The Space Domain and Critical Infrastructure

1056. Ghostwriting is more than just anonymous book writing — it's a thriving industry. Dan Gerstein, founder of Gotham Ghostwriters, shares how writers can break into ghostwriting, what types of projects are available, and how much top ghostwriters earn. Plus, we explore the ethical considerations of ghostwriting and how the industry is evolving.Dan Gerstein is founder and CEO of Gotham Ghostwriters, the country's premier ghostwriting agency. Featuring a network of more than 4,000 accomplished freelance editorial pros, Gotham specializes in sophisticated, long-form writing (such as books, speeches, and reports) for authors, speakers, and thinkers who need expert help telling and selling their stories. Gerstein, a graduate of Harvard College, has been writing and communicating professionally for more than 30 years. He started his career as a local sports and news reporter at the Hartford Courant. He then went on to spend more than a decade as a speechwriter and communications strategist on Capitol Hill and for two presidential campaigns, serving as a senior advisor to Senator Joe Lieberman from his home state of Connecticut.In 2004, Gerstein moved to New York to become a political consultant (primarily working with issue advocacy groups) and commentator. Known for his independent, thoughtful analysis, he has served as a contributing columnist for Forbes, the Wall Street Journal, and Politico. He has also appeared regularly on television as a political analyst for Fox News, CNN, MSNBC, WNBC-TV, and NY1.Among other pursuits, Gerstein, 57, has served as an adjunct faculty instructor in New York University's master's program in Public Relations and Corporate Communications; he currently serves on the board of the recently-launched 5Boro Institute in New York City. He lives in Manhattan with his wife Simona, their daughter Ella, and their dog Ugo.

In our latest episode, Roberto sits down with Noam Gerstein, CEO and founder of Bina, a global accredited virtual school pioneering precision education. Noam shares her visionary insights on online education, discussing the practicalities and wonders of teaching digitally, including the benefits of small class sizes, highly trained educators, real-time feedback, and a unique thematic approach to learning. Throughout the conversation, Noam elaborates on how Bina's innovative methods cater to young learners across diverse time zones and cultural contexts. She highlights the importance of social-emotional learning, cultural inclusivity, and maintaining student engagement through various interactive and collaborative strategies. Moreover, Noam provides a fascinating glimpse into the future of early childhood and elementary education, emphasizing the role of technology in creating more accessible, impactful, and personalized learning experiences. Welcome to Our Classroom!

In this episode, Zal Dastur interviews Ryan Shermahorn, a patent attorney and partner at Marshall, Gerstein & Borun, to explore the critical intersection of climate change, clean technology, and intellectual property. They dive into the Climate Change Mitigation Pilot Program, which accelerates the patent process for climate-focused innovations, highlighting how this program can benefit startups and smaller companies. Ryan explains why securing patents is essential for attracting investors, safeguarding innovations, and mitigating risks from patent trolls and counterfeiters. The conversation also unpacks the challenges of protecting AI-related patents, strategies for navigating international markets, and the often-overlooked resources available to clean tech innovators.

For more than 30 years Dr. Joseph Gerstein has been collecting stories from SMART participants about powerful emotional experiences related to their recovery journey. He has now written a captivating essay about the nature of these occurances that includes examples and analysis of what he calls "secular conversion experiences." His insight into the value of these experiences and the common elements found paints a picture of how our cognitive functions connect with the more emotive features of our lives. Dr. Gerstein is SMART's Founding President and a retired professor of medicine at Harvard Medical School. He has been instrumental in the growth of SMART in the U.S. and across the globe and has personally facilitated over 4,000 SMART meetings over 34 years. 

Beinahe wäre Kirill Gerstein Jazz-Pianist geworden, aber dann entscheidet er sich als Jugendlicher doch für die Klassik. Aber wenn man ihn hört, sein agiles, perlendes, transparentes Spiel, scheint der Jazz ihn allerdings nie verlassen zu haben. Gerstein wird weltweit als Solist gefeiert, passt aber nicht in den typischen Star-Reigen. Alles bei ihm ist individuell, nichts von der Stange, auch nicht sein vielseitiges, tief durchdachtes Repertoire.

In this episode of Why Distance Learning?, hosts Seth Fleischauer, Allyson Mitchell, and Tami Moehring welcome Noam Gerstein, CEO of the Bina School and a leading expert in precision education. Noam shares her journey of creating a global, digitally native school that reimagines how education serves young learners, blending emotional connection, cultural diversity, and innovative uses of live virtual learning. The episode explores Bina School's unique approach to play-based, personalized learning for students aged 4 to 12, with a focus on fostering global awareness and nurturing emotionally safe, collaborative learning environments.Key Topics Discussed:The importance of emotionally held learning spaces in live virtual education.How Bina School uses thematic biomes and SDG projects to create meaningful learning experiences.The role of adaptive content generation in balancing personalization and standardization.Building a global community for young learners and redefining what a school can be.Guest Bio: Noam Gerstein is the CEO of the Bina School, a pioneer in precision education and a thought leader in the field. With a background in history, technology, and social innovation, Noam has spent years researching global education systems and building solutions to meet the needs of Gen Alpha learners. She is a frequent speaker at education conferences and a passionate advocate for blending cultural diversity with cutting-edge technology.Host Links:Discover more virtual learning opportunities and resources at CILC.org with Tami Moehring and Allyson Mitchell.Seth Fleischauer's Banyan Global Learning provides meaningful global learning experiences that prepare students across the globe for success in an interconnected world.Episode Links:Bina School - thebinaschool.comContact Noam Gerstein: noam@bina.school

Daniel M. Gerstein is a senior policy researcher at RAND and professor of policy analysis at Pardee RAND Graduate School. Previously, he served at the U.S. Department of Homeland Security (DHS) as under secretary (acting) and deputy under secretary in the Science & Technology Directorate. Security Threats Posed by Drones

Politics War Room ON TOUR  - live show in Boston on 11/2 at politicon.com/tour  Watch Politics War Room & James Carville Explains on YouTube @PoliticsWarRoomOfficial James and Al share their takes on the candidates' closing arguments, contextualize Biden's garbage comment, and examine the effect of Trump's MSG rally before welcoming pollsters Jim Gerstein and Dr. Whit Ayers. They discuss the numbers going into the final week of the election, explore the most significant issues influencing voters, debate how the undecided might break, compare what we see to recent elections, and weigh the chances Colin Allred has of defeating Ted Cruz in the race for the Texas Senate seat. Email your questions to James and Al at politicswarroom@gmail.com or tweet them to @politicon.  Make sure to include your city– we love to hear where you're from! More from James and Al Get tickets for the Politics War Room live shows in Boston on 11/2 at politicon.com/tour  Get text updates from Politics War Room and Politicon. Watch Politics War Room & James Carville Explains on YouTube @PoliticsWarRoomOfficial CARVILLE: WINNING IS EVERYTHING, STUPID hits theaters November 1st at the Angelika in D.C.  Get tickets now at CarvilleDoc.com/tickets.  You can also get updates and some great behind-the-scenes content by following James on Twitter @jamescarville and his new TikTok @realjamescarville James Carville & Al Hunt have launched the Politics War Room Substack Get More From This Week's Guests:  Jim Gerstein: GBAO Strategies  Dr. Whit Ayres: Twitter | University of Chicago | North Star Opinion | AAPC | Author Please Support Our Sponsors: HelloFresh: Get 10 free meals at hellofresh.com/freewarroom applied across 7 boxes– new subscribers only, varied by plan. Naked Wines: To get 6 bottles of wine for $39.99, head to nakedwines.com/warroom and use code WARROOM for both the code and password.   Laundry Sauce: For 15% off your order, head to laundrysauce.com/warroom and use code WARROOM

This week drive deeper into the history of the Dumas Brothel, as we're guided through it's haunted rooms ahead of our lock-in.  Learn more about Addison and Chilling Paranormal at https://www.chillingparanormal.com/  The full rebroadcast will be available at theFrightdaySociety.org soon...  Watch the video version at http://youtube.com/frightday Questions? Comments?  True Tales of Terror? Call the Frightday Hotline: 1(833)374-4489 1(833)FRI-GHT9 Pick up our limited edition August shirt at http://shop.frightday.com Want more? Join the Frightday Society, at http://thefrightdaysociety.org As a Society Member, you'll have access to all Screamium content (Behind the Screams, It's Been a Weird Week, A Conversation With..., Toast to Toast PM with Wine Kelly, Cinema Autopsy, the Writers' Room, bonus episodes of Captain Kelly's Cryptids & Conspiracies, Byron's Serial Corner, and so much more! You'll also be part of our interactive community dedicated to the advancement of horror, hauntings, cryptids, conspiracies, aliens, and true crime. All things frightening. Keep our mini-fridges full of blood...I mean...not blood...normal things that people drink...by going to http://shop.frightday.com  Theme music by Yawns Produced by Byron McKoy Follow us in the shadows at the following places: @byronmckoy @kellyfrightday @frightday  This is an Audio Wool Original.

Following Biden dropping out of the race, Al and James tear apart the GOP's reaction to Kamala's rise, rebuke their racism, and lay out JD Vance's attacks on Trump before welcoming seasoned pollster Jim Gerstein.  They discuss Kamala's strong opening bid and why the American people are happy to have a different choice. Then, they encourage her campaign to focus on the rising cost of living, reforming immigration, and protecting abortion rights.  They also react to Netanyahu's reception in Washington, explain his precarious political situation, and highlight the electoral issues with Trump's VP choice. Email your questions to James and Al at politicswarroom@gmail.com or tweet them to @politicon.  Make sure to include your city– we love to hear where you're from! Watch James Carville Explains on YouTube Playlist James Carville & Al Hunt have launched the Politics War Room Substack Get More From Jim Gerstein  GBAO Strategies  Please Support Our Sponsor: Miracle Made: For 40% off high-quality self-cooling sheets, plus an extra 20% off with 3 free towels, use promo code WARROOM when you go to TryMiracle.com/warroom

In this episode of the 3DPOD, we take a deep dive into IP, patents, and more with Meggan Duffy, Partner at Marshall Gerstein. As an entrepreneur our co-host Max is especially engaged in this episode. It was very practical, offering a lot of actionable learnings on IP. The takeaway for me was that in our business, you need an IP strategy and must be very engaged with this subject. Chock full of practical information, this is a great episode to learn more about IP.

Kirill Gerstein's new album, timed for release mid-way between the anniversary of the death of Claude Debussy (March 25) and Armenian Genocide Remembrance Day (April 24), pairs music by Debussy and the Armenian, Komitas. Both composers were profoundly affected by the death and destruction surrounding them during the First World War, and both responded with music of multi-layered intensity. Gerstein links late Debussy piano music with Komitas's piano works, as well as songs by each composer. 'Music in the Time of War' is released to stream and download by Platoon, and on two CDs with a substantial book of essays next month by Myrios. James Jolly spoke to Kirill Gerstein to learn about the project and why he brought together these two powerful musical voices in the same programme. This Gramophone Podcast is produced in association with Wigmore Hall.

In the shadows of corporate greed and exploitation lies a sinister crime that is silently perpetrated, leaving countless victims in its wake—a crime that affects millions of hardworking Americans every year and sucks billions out of our economy —Wage Theft. No industry is immune to this insidious crime, from restaurant workers to construction laborers. On this episode of Pitchfork Economics, we are joined by Terri Gerstein, Director of the Labor Initiative at NYU Robert F. Wagner Graduate School of Public Service, to unpack the chilling truth behind these workplace crimes, learn who the perpetrators are, and uncover how they get away with it. Most importantly, what can be done to stop them? Terri Gerstein is the Director of the NYU Wagner Labor Initiative, at NYU's Robert F. Wagner Graduate School of Public Service, which explores and helps activate the often-untapped potential of government in safeguarding and advancing workers' rights. Previously, Terri enforced labor laws in New York for 17 years, including as Labor Bureau Chief in the New York State Attorney General's Office. Crime music bed by Power Music Factory News clips from CBS News, CBS Miami, and CBS Philadelphia Twitter: @TerriGerstein  NYU Wagner Labor Initiative Further reading:  Prosecute Bad Bosses: More district attorneys are cracking down on abusive employers. It's about time Report mentioned in the episode from the National Coalition Against Insurance Fraud: The Costly Crime and Impact of Workers' Comp Premium Fraud The Role of State Attorneys General in Protecting Workers' Rights Report: How district attorneys and state attorneys general are fighting workplace abuses More states should follow new Colorado policy on wage theft Website: http://pitchforkeconomics.com Twitter: @PitchforkEcon Instagram: @pitchforkeconomics Nick's twitter: @NickHanauer

Daniel (Dan) M. Gerstein is a senior policy researcher at the RAND Corporation. Previously, he served at the U.S. Department of Homeland Security (DHS) as under secretary (acting) and deputy under secretary in the Science & Technology Directorate.   Emerging Technology and Risk Analysis: Artificial Intelligence (AI) and Critical Infrastructure

Daniel M. Gerstein, board member of the Pandemic Mitigation Project, formerly served as the acting undersecretary and deputy undersecretary in the Department of Homeland Security's Science and Technology Directorate from 2011 to 2014. Hidden in Plain Sight: the Next Biosecurity Threat

In this episode: Frank is talking with ⁠Noam Gerstein, the CEO of the bina school - a fully online primary transnational school for kids aged 4-12. Noam started university at 16 in Tel-Aviv, worked for physichians for human rights. Founded, bootstrapped and exited a business at 26. Then did more than 7+ years of global K-6 research that culminated in the bina school. We talk about: The need to solve serious problems as an entrepreneur and not small consumer problems of discomfort, how building a school takes time, effort and careful adjustment, how entrepreneurship is like eating dirt for a long time, why getting a white male in the room helps for funding ….and lots more. Outtakes: When kids go to a local school, they meet their local peers, and the educators that are available to them are the ones that are in their neighborhood, more or less. In Bina, children can learn with children from the very north to the very south of their time zone. They are matched according to their needs, not according to their location. Also to their educators by the way. And then we see wonders like two kids from very different sides of the aisle or of the wall or of the war learning together every day and becoming best friends. And that's marvelous. I think, you know, success would be to walk into a village in the middle of nowhere and that there are children there in multiple aged, in a grandma's hut or whatever, that are all recipients of like the world's best education. That's the dream, right? So either you have a strong enough network or enough financial resources to put things off the ground on your own with whatever it takes, and then start when you have something to actually sell. That's a one option. Or you like eat dirt for like four years. And hopefully you have the ability to do both. The ⁠⁠⁠⁠⁠⁠⁠EdTech Garage⁠⁠⁠⁠⁠⁠⁠ is a community for early-stage European EdTech startups where founders can scale up faster through the founder community, matchmaking and specialized resources. In this podcast series we interview startup founders & players supporting early-stage EdTech startups from across Europe. We get straight to the point in 20+ minutes and publish new episodes roughly every month. You can find the transcript from each podcast on the site below. Join the community on ⁠⁠⁠⁠⁠⁠⁠edtechgarage.org⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠Follow us on Linkedin⁠⁠⁠⁠⁠⁠⁠ (⁠⁠www.linkedin.com/company/edtechgarage/⁠⁠) Host: ⁠⁠⁠⁠⁠⁠⁠Frank Albert Coates⁠⁠⁠⁠⁠ Music: ⁠⁠⁠⁠⁠Ehsansation

In this episode, Made for Impact host Gretchen Schott and guest Mara Gerstein discuss the importance of self-awareness and self-exploration in personal and professional growth. Mara, Co-Founder and CEO of Loupe Ventures, a self-awareness tool that turns feedback into actionable data and insights takes us through the power of a growth mindset, how to take your leadership skills to the next level through feedback, and developing a high-performing culture. Additional Resources: Connect with Gretchen Schott on LinkedIn  Connect with Mara Gerstein on LinkedIn  Original Episode Made for Impact Podcast Call for a Feedback Revolution Loupe Ventures Website More on PeopleForward Network Follow PeopleForward Network on LinkedIn  

James and Al skewer so-called family values Republicans after recent scandals and welcome polling experts Fred Yang and Jim Gerstein.  They dive into the weak numbers being put up by the Biden campaign, analyzing what's bringing them down, the composition of the electorate, the role of 3rd party candidates, the messaging challenges ahead, and how to take the lead.  They cover the effects of inflation, the crisis at the border, the lack of enthusiasm among young and minority voters, the Israel-Hamas war, and whether Dobbs has given Democrats a silver bullet.  Plus with the year kicking off, James and Al tackle the latest in college sports as long time fans. Email your questions to James and Al at politicswarroom@gmail.com or tweet them to @politicon.  Make sure to include your city, we love to hear where you're from! Check James Carville's new videos: James Carville Explains… Moms For Liberty #TrumpStinks James Carville Explains… Why Mike Johnson is a P.O.S. James Carville Explains… everything about Mike Johnson James Carville on the trail of Lauren Boebert Get More From This Week's Guests: Jim Gerstein  GBAO Strategies  Fred Yang: Twitter | Hart Research  Please Support Our Sponsors: Henson Shaving: Go to hensonshaving.com/pwr and enter PWR at checkout to get 100 free blades with your purchase. (Note: you must add both the 100-blade pack and the razor for the discount to apply.) Zbiotics: Get back into action with Zbiotics with 15% off your first order of the perfect solution to a night out when you go to zbiotics.com/pwr and use code: PWR

What is Asset Framing? We talk with Anat Gerstein, Founder and President, on a new push to help properly and respectfully report on at-risk and marginalized populations. Anat started her namesake named firm in 2010 after years of seeing first-hand the support nonprofits need to effectively tell their story. Prior to starting her business, Anat was chief of staff and press secretary to NYC Public Advocate Betsy Gotbaum; provided public relations services to top healthcare companies, including Eli Lilly and Cigna; developed effective communications materials for social service and other non-profits; and promoted political candidates at the state and local level. She began her career nearly 25 years ago in the advertising sector, working on consumer brands such as Vicks and Crest. Anat is a graduate of New York University's Stern School of Business and a Sabra (Israeli native). Anat served on The New York Community Trust Nonprofit Excellence Awards Selection Committee from 2013 to 2018. The PR Podcast is your view inside the public relations business. We talk with great PR people, reporters, and communicators about how the news gets made and strategies for publicity that drive business goals.  Host ⁠⁠Jody Fisher⁠⁠ is the founder of JodyFisherPR and works with clients across the healthcare, higher education, financial services, real estate, entertainment, and non-profit verticals.  Join the conversation on ⁠⁠Facebook⁠⁠, ⁠⁠Twitter⁠⁠, ⁠⁠Instagram⁠⁠, and ⁠⁠TikTok⁠⁠ at @ThePRPodcast. --- Support this podcast: https://podcasters.spotify.com/pod/show/theprpodcast/support

"Understanding ourselves is a never-ending journey, and feedback from others can be a valuable compass that guides us towards our true potential." Mara Gerstein is the Co-Founder and CEO of Loupe Ventures, a self-awareness tool that turns feedback into actionable data and insights. She has a passion for innovation and has played a pivotal role in nurturing and empowering emerging tech companies. In this episode of Made For Impact, Mara discusses the power of a growth mindset, how to take your leadership skills to the next level through feedback, and developing a high-performing culture.  In this episode, you'll learn:  The importance of self-awareness and self-exploration in personal and professional growth. The challenges and limitations of traditional performance management systems and how they can be improved. Strategies and tools for creating a positive feedback culture in organizations that foster growth, engagement, and productivity.   Connect with GUEST: https://www.linkedin.com/in/mara-gerstein-ba74a014/ Check out Loupe Ventures: www.AskLoupe.com   Get in touch with Gretchen, and let her know which impactful leaders you'd like to hear from: Connect on LinkedIn or Subscribe to our newsletter.   Loved this episode? Leave us a review and rating here: https://link.chtbl.com/3EbmWF5a   

Following the tragic attack on Israel by Hamas, James and Al are joined by political strategist Jim Gerstein to break down the situation on the ground and its regional ramifications.  They delve into the potential for a wider conflict, how a follow-up invasion can destroy the prospects for Middle East peace, and how the Israeli government is responding.  Then, they welcome Brigadier General Ty Seidule to examine the tactics used and the harm to our military readiness caused by Republicans.  Between their war on the diversity of our troops and Senator Tuberville's blockade of military promotions, are we ready for the next crisis?    Email your questions to James and Al at politicswarroom@gmail.com or tweet them to @politicon.  Make sure to include your city, we love to hear where you're from! Get More From This Week's Guests: Jim Gerstein  GBAO Strategies  Brigadier General Ty Seidule (Ret.): Twitter | West Point | Website | Hamilton College | New America | Author of “Robert E. Lee & Me” Please Support This Week's Sponsors: Lomi: Turn your food waste into plant-food at the press of a button with Lomi. Use the code WARROOM to save $50 at lomi.com/WARROOM Zbiotics: Get back into action with Zbiotics with 15% off your first order of the perfect solution to a night out when you go to zbiotics.com/pwr and use code: PWR Miracle Made: For 40% off high quality self-cooling sheets plus an extra 20% off with 3 free towels with promo code WARROOM, go to trymiracle.com/warroom

The Gramophone Award-winning pianist Kirill Gerstein has recorded Rachmaninov's Second Piano Concerto with the Berliner Philharmoniker and Kirill Petrenko: it forms part of a twinned release, 'Rachmaninoff 150', from Platoon. James Jolly met up with Gerstein a couple of months ago in London to talk about playing the music of a composer who left us two recordings of the concerto as well as being one of the greatest pianists ever to have lived. The second part of the programme includes solo works, with the Corelli Variations forming the centrepiece.

Canna-tourism generated $17B+ last year, and a wave of state legalization means that number will only get higher.  Brooke is the owner of Green Bonnet Pharms in Oklahoma, a complete vertically integrated cannabis business from seed to smoke, and she takes us through the challenges and opportunities in a travel sector primed for growth (and green).https://www.greenbonnetco.com/https://www.instagram.com/greenbonnetpharms/https://www.budandbreakfast.com/https://www.instagram.com/campcana/

Come along for an engrossing program of musical storytelling as Thomas Adès conducts Liszt's swirling treatment of the Faust legend, Janáček's depiction of a 17th-century Cossack warrior and Sibelius' incidental music to Shakespeare's The Tempest. Kirill Gerstein presents Adès' own Piano Concerto, “an affectionate, joyous, remarkably uncomplicated tribute to tradition” (The New York Times). Learn more: cso.org/performances/22-23/cso-classical/ades-conducts-ades-with-gerstein

Daniel M. Gerstein works at RAND and is an adjunct professor at American University. He formerly served as the undersecretary (acting) and deputy undersecretary in the Science and Technology Directorate of the Department of Homeland Security from 2011 to 2014. Healthy nation, safe nation: Build health security into national security

For the first episode of 2023, I called my friend, Terri Gerstein to discuss the issue of wage theft, the importance of prosecuting employers who steal from their workers, and the next frontier for worker protections. Terri Gerstein is the Director of the State and Local Enforcement Project at the Harvard Law School Labor and Worklife Program, and also a Fellow in the Program. She recently completed an Open Society Foundations Leadership in Government fellowship. Previously, she worked for over 17 years enforcing labor laws in New York State, including as the Labor Bureau Chief for the New York State Attorney General's Office, and as a Deputy Commissioner in the New York State Department of Labor. Before her government service, Terri was a nonprofit lawyer in Miami, Florida, where she represented immigrant workers and also co-hosted a Spanish language radio show on workers' rights. Her work has appeared in publications including The New York Times, The Washington Post, The Nation, The Guardian, and The Hill, among others; a complete listing can be found here. She has also appeared on Democracy Now, Univision and Telemundo. She's a graduate of Harvard College and Harvard Law School. Follow Terri on Twitter: @TerriGerstein Visit Terri's website: https://www.terrigerstein.com Please rate, subscribe, and share the show. Follow us on social media: Twitter @AGEllison, Facebook @AGEllison, Instagram @agkellison, and TikTok @agkeithellison

This week on the podcast I am joined by Nancy Gerstein. Nancy is a yoga and meditation teacher, author, and the founder of Motivational Yoga, a practice that helps empower and clarify one's life decisions, goals, and results. Her classes feed body and mind, encouraging students to make conscious choices about how they direct thoughts, energy, and focus to live the best life they can. In this episode, Nancy and I dive into discussing how to plan and promote a workshop both in-person and online. Nancy shares her top tips for deciding your workshop idea, planning for your workshop, marketing your workshop, and then executing and delivering. Enjoy! *This episode originally aired in June 2021

The United States has been the leader in digital technology and innovation for decades. However, in recent years, the race between countries to control this space has become closer than ever. In this episode of Big World, SIS professor Daniel Gerstein joins us to explore the global technology war and the power that comes from being its winner at every stage. Gerstein discusses his new book “Tech Wars: Transforming US Technology Development” (1:25) and how the US rose to the top of the global technology and innovation race (2:31). He explains how US innovation has benefitted the rest of the world (5:28) and the US government's role in technological innovation (10:04). How are innovations like airplanes, medical equipment, smartphones, and the internet regulated (13:04)? What are the dangers of unregulated social media sites (22:02)? Gerstein answers these questions and discusses the importance of collaboration and evaluation to tackle data privacy and free speech concerns online (25:16). The episode concludes as Gerstein shares his thoughts on whether China and the US can ever have a symbiotic technology relationship (26:32). During our “Take Five” segment, Gerstein forecasts five innovation trends as the US continues to compete in the global technology war (17:14).

On this week's Leadership Launchpad Project podcast, Dr. Sam Gerstein, the CEO of Dreams for Real, joins Susan Hobson & Rob Kalwarowsky. We talk about Sam's journey from emergency medicine into business coaching, the impacts of stress on health and why leaders need to connect to their passion & purpose/ In this episode, you will learn: ⊛ How to connect to your purpose ⊛ How to pivot into your dream career ⊛ The impacts of stress and burnout on health We at Elite High Performance specialize in building high impact leaders that turn their teams into happy high-performers who crush their goals. A prime example is our client, MiQ who has increased their revenue by 35% YOY, has 83% employee engagement when the global average is 21% and reduced turnover by 52% YOY. Can you afford to leave revenue, productivity on the table and afford to lose your employees? If you can't, visit elitehighperformance.com for the best, research-backed, high-performance leadership strategies that will build you into a high-impact leader who turns their teams into happy high performers that achieve their goals. Rather than traditional leadership coaching, Elite High Performance blends neuroscience, mindset coaching, high-performance leadership strategies with cutting-edge technology & data to provide a clear path to building a high-performing team - or to turn around an under-performing team. It's the same way professional sports teams combine high-performance coaching, technology and analytics to build a winning sports team. Find the Leadership Launchpad Project on Amazon - www.amazon.com/leadershiplaunchpad Connect with Rob Kalwarowsky on LinkedIn - https://www.linkedin.com/in/robert-kalwarowsky/ Connect with Susan Hobson on LinkedIn - https://www.linkedin.com/in/jumpstartliving/ Connect with Dr. Sam Gerstein on LinkedIn - https://www.linkedin.com/in/samgerstein/ Check out Dreams for Real - https://custom-fitbusiness.com/ Check out Sam's YouTube Channel - https://www.youtube.com/watch?v=Zl1e6u2CYTE Check out - elitehighperformance.com

Women have more control over their life and fertility than we may recognize. Mara Gersten walks us through her thought process and actions to conceive, birth and raise her daughter on her own. She is an inspiration in so many ways and encourages any listener wanting to parent solo from the start to go for it.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Members Miles Gerstein and Susan Davis talk about their family's Jewish journey, and how they came to Central.

Daniel M. Gerstein is a senior policy researcher at the RAND Corporation. Previously, he served at the U.S. Department of Homeland Security (DHS) as under secretary (Acting) and deputy under secretary in the Science & Technology Directorate. Harnessing the Power of Science and Technology Communities for Crisis Response

America is a beautiful place of second chances and limitless opportunity.  It's also a place that will point and laugh as you publicly fall from grace and will talk trash about you the whole way down.  That brings us to the subject of today's show, Rudy Giuliani.  Giuliani started at the bottom and worked his way to some of the most prestigious offices within the legal system of New York City, eventually becoming mayor.  Rudy was the darling of New York, people admired his work and it seemed he could do no wrong.  But over time, Rudy faded from the spotlight as most politicians do… until he reappeared, with crazy eyes, melting hair, and lots to say.  As Donald Trump's personal attorney, Giuliani was at the forefront of the 2020 election and the aftermath.  Was there one certain event that took Giuliani from public darling to the butt of jokes?  Was that really his fake hair melting?  Who set up that infamous press conference at the Four Seasons Landscaping Company?  We'll dive into these questions and more in the Rudy Giuliani episode of AHC Podcast.         Intro Music Credits: Dar Golan - Royalty free army music https://www.youtube.com/watch?v=2tbj1YElpg4         Citations: Bromwich, J. E. (2020, November 19). Whatever it is, it's probably not hair dye. The New York Times. Retrieved August 13, 2022, from https://www.nytimes.com/2020/11/19/style/rudy-giuliani-hair.html Bump, P. (2021, April 28). Analysis | A timeline of Giuliani's dubious interactions with the Trump administration. The Washington Post. Retrieved August 13, 2022, from https://www.washingtonpost.com/politics/2021/04/28/timeline-giulianis-dubious-interactions-with-trump-administration Kruse, M., White, J. B., Sitrin, C., Gerstein, J., Sutton, S., & Mahoney, B. (2019, October 18). Friends with benefits: Donald and Rudy's long, strange partnership. POLITICO Magazine. Retrieved August 13, 2022, from https://www.politico.com/magazine/story/2019/10/18/trump-giuliani-ukraine-lawyer-new-york-history-friendship-229857/ Lahut, J. (2020, December 4). Michigan State Representative confirms Rudy Giuliani farted during an election hearing. Business Insider. Retrieved August 13, 2022, from https://www.businessinsider.com/rudy-giuliani-fart-on-camera-confirmed-by-michigan-state-representative-2020-12 Mitchell, T. (2020, December 7). The rise and fall of Rudy Giuliani. ICON. Retrieved August 13, 2022, from https://icon.ink/articles/the-rise-and-fall-of-rudy-giuliani/ Roane, K. R. (2006, August 24). Myths of a 9/11 hero, debunked. Los Angeles Times. Retrieved August 13, 2022, from https://www.latimes.com/archives/la-xpm-2006-aug-22-et-book22-story.html Shoard, C. (2020, October 21). Rudy Giuliani faces questions after compromising scene in New Borat Film. The Guardian. Retrieved August 13, 2022, from https://www.theguardian.com/film/2020/oct/21/rudy-giuliani-faces-questions-after-compromising-scene-in-new-borat-film Taseer, A. (2021, August 5). How Rudy Giuliani went from 9/11's hallowed mayor to 2021's Haunted ghoul. Vanity Fair. Retrieved August 13, 2022, from https://www.vanityfair.com/news/2021/08/how-rudy-giuliani-went-from-911s-hallowed-mayor-to-2021s-haunted-ghoul Wikimedia Foundation. (2021, June 3). Rudy Giuliani: Urban legend. Wikipedia. Retrieved August 13, 2022, from https://en.wikipedia.org/wiki/Rudy_Giuliani:_Urban_Legend Wikimedia Foundation. (2022, August 5). Legalized abortion and crime effect. Wikipedia. Retrieved August 13, 2022, from https://en.wikipedia.org/wiki/Legalized_abortion_and_crime_effect Wikimedia Foundation. (2022, August 6). François Duvalier. Wikipedia. Retrieved August 13, 2022, from https://en.wikipedia.org/wiki/Fran%C3%A7ois_Duvalier Wikimedia Foundation. (2022, July 26). Rudy Giuliani. Wikipedia. Retrieved August 13, 2022, from https://en.wikipedia.org/wiki/Rudy_Giuliani Wikimedia Foundation. (2022, June 14). Lead–crime hypothesis. Wikipedia. Retrieved August 13, 2022, from https://en.wikipedia.org/wiki/Lead%E2%80%93crime_hypothesis

On this episode, Liz sits down with the CEO and Co-Founder of Brilliant Earth, Beth Gerstein, to discuss how she developed one of the world's largest and fastest-growing fine jewelry companies out of her one-bedroom apartment in San Francisco. Beth shares how she entered the jewelry business with zero experience or connections and is now running a publicly traded ethical jewelry company with more than 370,000 customers in over 50 countries. Later, Beth talks about the importance of lab-grown jewelry, conflict-free gems, and blockchain-enabled diamonds in order to trace the origins and make sure pieces are ethically sourced. Follow Liz on Twitter: @LizClaman Learn more about your ad choices. Visit megaphone.fm/adchoices

On today's episode, I'm going continue my discussion on personality development.   I have always found personality development to be interesting ever since I sat in college listening to a professor discuss whether or not there people have a soul.  In this episode, my goal is to provide a brief overview of Gestalt Theory and its approach to personality development.  This therapy came from the work of Fritz and Laura Perls and their focus on people and being more than the sum of our parts.  The therapy focuses on self awareness and confronting blocks to achieve full potential.  The majority of the educational materials for this series comes from Ginter, Roysircar, and Gerstein (2019) Theories and Applications of Counseling and Psychotherapy, which can be found at https://www.amazon.com/Theories-Applications-Counseling-Psychotherapy-Relevance/dp/1412967597Intro/Outro music & Transition Sounds, ambient-atmospheric-4947, found at https://cdn.pixabay.com/download/audio/2021/06/07/audio_cdfb955189.mp3?filename=ambient-atmospheric-4947.mp3National Suicide Prevention Hotline - 1 (800) 273-8255National Domestic Violence Hotline -1 (800) 799-7233National Sexual Assault Hotline - 1 (800) 656-4673Crisis Text Line - Text “MN” to 741741Call 911 for emergencyThis and other content produced by James Rains is not therapy, not intended to be therapy or be a replacement for therapy.  Nothing in this podcast creates or indicates a therapeutic relationship.  Please seek help from your therapist or seek help from one in your area if you are experiencing any mental health concerns.  Nothing should be construed to be specific advice.  It is for educational and entertainment purposes only.

After being unable to find an ethically sourced diamond engagement ring, Beth Gerstein took matters into her own hands and co-founded Brilliant Earth in 2005. In the years to follow, Brilliant Earth disrupted industry practices by selling diamonds from ethically and environmentally responsible sources. “About two-thirds of the diamond industry is [made up of] neighborhood jewelers, so it's an industry that hasn't really evolved,” says Gerstein on the latest Glossy podcast.  Brilliant Earth prides itself on the highly personal experience it provides its customers in-store. The brand has 20 showrooms throughout the U.S. Its latest opened in Edina, Minnesota on June 2. It plans to open up to 15 more locations 2022.  During the pandemic in 2021, Brilliant Earth saw a 51% increase in annual net sales, reaching $380 million. And its first-quarter 2022 earnings report showed $100 million in net sales. Gerstein credits the brand's success to its nimble supply chain. Beyond selling ethical jewelry, Brilliant Earth partners with social programs like Feeding America and the Rainforest Alliance to further its global advocacy mission. 

This week, please join author Ronald Goldberg, Editorialist Hertzel Gerstein, and Guest Editor Rury Holman as we discuss the article "Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study" and the editorial "Shouldn't Preventing Type 2 Diabetes Also Prevent Its Long-Term Consequences?" Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your co-host. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Centre and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor, Director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Dr. Carolyn Lam: Today. Oh, this feature discussion involves the glance of diabetes. Truly this interview, I felt like I was sitting among gurus and just learning so much about diabetes, the history and the whole topic is about long term metformin and lifestyle interventions on cardiovascular events in the Diabetes Prevention Program and its outcome study. Now, way more than that, we discussed. You have to have to listen. But okay, before that, let's summarize today's issue for our listeners. Shall we, Greg? Dr. Greg Hundley: You bet Carolyn. So the first paper that I've got to discuss today really comes to us from the world of interventional cardiology and it's led by Dr. William Fearon from Stanford University Medical Center. Well, Carolyn previous studies have shown quality of life improves after coronary artery revascularization, more so after coronary artery bypass grafting than after PCI. Now this study aimed to evaluate the impact of fractional flow reserve guidance, and current generation zotarolimus drug-eluting stents on quality of life after PCI compared with CABG. Dr. Greg Hundley: Now the study emanates from fractional flow reserve versus angiography for multi vessel evaluation or the fame three trial. And Carolyn, that's a multicenter international trial that included 1500 patients with three vessel coronary artery disease who were randomly assigned to either CABG or FFR guided PCI. Now, what did they assess? So quality of life was measured using the European Quality of life Five Dimensions. And we're going to abbreviate that EQ-5D questionnaire baseline, one, and then 12 months following the procedure. Also, Canadian cardiovascular class angina grade and working status were assessed at the same time points, and then also an additional time point in six months. And the primary objective was to compare the EQ-5D summary index at 12 months, and secondary endpoints included angina grade and work status. Dr. Carolyn Lam: Ooh, interesting Greg. So quality of life in the theme three trial. All right. So what did they find? Dr. Greg Hundley: Right, Carolyn. So the EQ-5D, so that... European Quality of life Five Dimensions summary index at 12 months did not differ between the PCI and CABG groups, but the trajectory over the 12 months at the one month time interval between PCI and CABG did differ. Now, the proportion of patients with the Canadian cardiovascular class or CCS2 or greater angina 12 months was 6.2% versus 3.1% respectively in the PCI group compared with the CABG group. Additionally, a greater percentage of younger patients, so those less than 65 years old were working at 12 months in the PCI group compared with the CABG group. So in summary, Carolyn, in the fame three trial, quality of life after fractional flow reserve guided PCI with current generation DS compared with CABG was similar in one year. And the rate of significant angina was low in both groups and not significantly different. However, the trajectory of improvement in quality of life was significantly better with PCI as was working status in those less than 65 years old. Dr. Carolyn Lam: Wow. Thanks Greg. Hey, guess what? It's time for Greg quiz. The next paper is about the Chocolate Touch Study. So, Greg, is this about, A, the benefits of eating chocolate? B, the benefits of chocolate mud baths? Or C, the benefits of a second generation drug coated balloon? Dr. Greg Hundley: So, Carolyn, I just have one question. Where in the world do we get the benefits of chocolate mud bath? I don't think that's right. I do love eating chocolate, but I am going to go with the benefits of the second generation drug coated balloon. Dr. Carolyn Lam: Yeah, yeah, yeah. I made it easy for you. All right. So first generation drug coated balloons have significantly reduced the rate of restenosis compared to balloon angioplasty alone. However, high rates of bailout stenting and dissections persist. The chocolate touch drug coated balloon is a nitinol constrained balloon designed to reduce acute vessel trauma and inhibit neointima formation and restenosis, so you were right, Greg. In today's study led by Dr. Shishehbor, from University Hospital's Harrington Heart and Vascular Institute at Cleveland, Ohio. They studied 313 patients with claudication or ischemic rest pain, and superficial femoral or popliteal disease. And randomized them one to one to the chocolate touch or Lutonix Drug Coated Balloon at 34 sites in the United States, Europe and New Zealand. The primary efficacy endpoint was drug coated balloon success defined as primary patency at 12 months. The primary safety endpoint was freedom from major adverse events at 12 months. A composite of target limb related death, major amputations, or reintervention. Both primary endpoints was assessed for non-inferiority and have met sequential superiority testing for efficacy was pre-specified. Dr. Greg Hundley: Interesting, Carolyn. So this nitinol constrained balloon designed to reduce acute vessel trauma. So, what were the results of this study? Dr. Carolyn Lam: So in this trial, the second generation chocolate touch drug coated balloon met both non-inferiority endpoints for efficacy and safety. And was more effective than the Lutonix Drug Coated Balloon at 12 months for the treatment of femoral popliteal disease. Cool, huh? Dr. Greg Hundley: Very interesting. Great summary, Carolyn. So Carolyn, my next paper comes to us from the world of preclinical science. And the impact of three dimensional chromatin topology on transcriptional dysregulation and pathogenesis in human dilated cardiomyopathy remains elusive. And so these authors led by Professor Lei Jiang from Guangdong Provincial People's Hospital, and Guangdong Academy of Medical Science, generated a compendium of 3D epigenome and transcriptome maps from 101 biobank human dilated cardiomyopathy, and non-filing heart tissues and mouse models to further interrogate the key transcription factor implicated in 3D chromatin organization, and transcriptional regulation in dilated cardiomyopathy pathogenesis. Dr. Carolyn Lam: Oh, wow. Sounds like a lot of work. What did they find, Greg? Dr. Greg Hundley: Right, Carolyn. So they found that enhancer promoter connectomes are extensively rewired in human dilated cardiomyopathy, which reside in pre accessible chromatin size and also hand one drives the rewiring of enhancer promoter connectome to induce dilated cardiomyopathy pathogenesis. Dr. Carolyn Lam: Okay, Greg. So what are the clinical implications? Dr. Greg Hundley: Right, Carolyn. So first, dilated cardiomyopathy enriched enhancer promoter loops identified in this study could be developed as novel 3D genomic biomarkers for dilated cardiomyopathy. And then second Carolyn, targeting hand one might be used as a novel approach for therapeutic intervention in patients with dilated cardiomyopathy. Dr. Carolyn Lam: Oh, nice. Greg. Well, also in today's issue, there's an On My Mind paper by Dr. Brook, entitled, “The Doctor is Out, New Tactics and Soldiers For our Losing Battle against Hypertension.” In another paper, we have Molly Klemarczyk bringing us highlights from the Circulation Family of Journals. Dr. Greg Hundley: Right, Carolyn. And also from the mailbag, there's a Research Letter from Professor Baggish, entitled, “Cardiovascular Outcomes in Collegiate Athletes, Following SARS-CoV-2 Infection: The 1-Year Follow Up From the Outcomes Registry for Cardiac Condition in Athletes.” Well, Carolyn, how about now we get onto that feature discussion and learn a little bit more about the long term metformin and lifestyle interventions on cardiovascular events in the Diabetes Prevention Program. Dr. Carolyn Lam: Hold on to your seats, everyone. Here we go. We know that lifestyle intervention and metformin have been shown to prevent diabetes. However, what is their efficacy in preventing the cardiovascular disease associated with diabetes development? Well, guess what? We're going to have data on that through today's feature paper and what a star crowd I'm talking to today. We have Dr. Ron Goldberg and he's a first end corresponding author from the University of Miami Diabetes Research Institute. We have the editorialist Dr. Hertzel Gerstein from McMaster University Population Health Research Institute. And a guest editor for this paper, Dr. Rury Holman from University of Oxford. I have to admit I'm starstruck. You gentlemen have totally defined the field. I cannot wait to learn more, but shall we start with you, Dr. Goldberg? Could you tell us a little bit more about your paper, what you did, what'd you found? Dr. Ronald Goldberg: So the background is that the Diabetes Prevention Program started in 1996 was a Diabetes Prevention Program to test the effects of intensive lifestyle intervention versus metformin, versus placebo on the prevention of diabetes in over 3000 individuals with impaired glucose tolerance, a form of prediabetes. And after demonstrating the efficacy of those interventions over about three years, we went on to do a follow up study in which the metformin group continued to receive it. Everybody got lifestyle because it worked so effectively. And we are now reporting after a further 18 years of follow up on the question of whether these interventions, now 21 years later, had any effect on cardiovascular outcomes. The background to that of course, is that people with prediabetes have a somewhat increased risk for heart disease and that rate increases as diabetes develops, particularly with severity of hyperglycemia and duration of diabetes. So, that was the study and we're now reporting on whether these interventions had a significant effect on the major cardiovascular. Dr. Carolyn Lam: Well, first Dr. Goldberg, congratulations on the foresight to get the informed consent and to plan ahead to be able to get these valuable data. But because I know this is going to be a critical point later. Could you tell us a little bit about the completeness of follow up and perhaps surveillance for outcomes before you share the results? Dr. Ronald Goldberg: Absolutely. So, 86% of the original randomized group of participants agreed to continue with a follow up study, so there was a loss at that point. And then of course, over 18 years of follow up, there's going to be a further loss. Some due to death and some due to loss to follow up. But despite that, I would say the group that entered the follow up study, we were able to maintain follow up in 85%. Dr. Carolyn Lam: Fantastic. And the results? Dr. Ronald Goldberg: The findings were that we found no significant effect of either of the two active interventions on our primary cardiovascular outcome, which was nonfatal myocardial infarction, stroke and fatal cardiovascular disease. We also had an extended outcome with more events in it, and similarly found no significant benefit or harm from either of those two intervention. Dr. Carolyn Lam: Oh, I love that paper. What a great, great, perhaps surprising conclusion that Dr. Gerstein loved the title of your editorial, you crystallize it. Shouldn't preventing type two diabetes also prevent long term consequences? So please tell us what was your thoughts when you saw this paper and how you frame it? Dr. Hertzel Gerstein: Thanks very much, Carolyn. And first of all, I was very impressed by the extensive amount of work and analysis done by Dr. Goldberg and his team. I thought that it's wonderful to see this sort of long term follow up. I've had the privilege in the past of speaking together with the DPP team on their trial and in their long term follow up. And I continue to be impressed by the extensive amounts of work and data collected and a rigor and academic value of the analysis. So, that was my very first impression and obviously it's a pleasure to write on this. I think the findings are clearly important and they both highlight the importance of long-term follow up as well as highlight the difficulties of long-term follow up in a study like this. Dr. Hertzel Gerstein: So this was a study done in a trial, originally done in a fairly young cohort of individuals who had very low risk for cardiovascular events. And over their 18 year follow up that Dr. Goldberg Ron described, the actual annual event rate for the primary outcome was 0.6% per year in that ballpark. Now, anybody... I've had the privilege as Ron Avery of doing many cardiovascular trials and we all know that we would never start a trial recruiting people with an event rate of 0.5% per year, 0.6% per year, because we would have to recruit 30,000 people and follow them for seven years in order to accrue enough events to be able to detect a clinically relevant benefit of the therapy. So because of this low event rate, the advantage was the long term follow up, the 26th year, I think it was in the end follow up. No, it was a 21 year median follow up period, because of the long follow up, you get a little bit away from the advantage of the low event rate. Dr. Hertzel Gerstein: But even then, over the course of the 21 years, there were only about 310 first cardiovascular events and most cardiovascular outcomes trials, for instance, we need close to at least a 1000, 500 to a 1000 is what we like to see. So that being said, it's perhaps not surprising that we didn't see a benefit of diabetes prevention because even if diabetes reduces the risk of a cardiovascular event by a quarter, by 25%, there would've only been a 50, 50 chance of detecting that with this particular cohort of people. Dr. Hertzel Gerstein: So I would say that the most conservative assumption is that diabetes prevention doesn't reduce the event rate by 25% or less or 30, but it's certainly... pardon me, by 25% or more, it could reduce it by 20%, 15% we would not have detected at all, or Ron would not have detected and his team would not have detected it with this thing. So I think that to me is the most important caveat in interpreting this does not mean that diabetes prevention has no effect on cardiovascular outcomes. Dr. Hertzel Gerstein: It means that diabetes prevention doesn't have a moderate or smaller effect. So, that's I think the most important message to take and as is even mentioned in the paper by Ron and the team is that there has been at least one diabetes prevention trial conducted in China many, many years ago that showed clearly that people who were randomly assigned to the diabetes prevention arm, 26 years later did have lower cardiovascular events and even death than people who were in the control arm. So, I think this adds to the story but it's clearly like everything, not the final word in this, but it certainly adds a lot of important data. Dr. Carolyn Lam: Oh, I would love to hear Dr. Goldberg's response to that. But before that, Dr. Holman, could I ask you to weigh in as well? Dr. Rury Holman: Yes. Sure. So, I agree with Hertzel that this is underpowered, but this is a question I've long wanted to see the answer to. And I congratulate Ron and his team for actually doing the work. All major studies should have long term follow up. People should be consented for life so that we can answer these questions. And Hertzel even though the power is perhaps minimal, we still need to do this analysis. Dr. Rury Holman: And if there had been a dramatic result, then we'd have all been very excited. I think one of the issues... one, if I could just bring it up, you mentioned the look ahead study in your discussion as being a negative dietary intervention. But I have a slightly different take on that. When you look at that paper in detail, what you see is that the people in the usual care group forgot quite a lot more risk factor reduction medications, and that's because their usual care physicians spotted the fact that their risk factor levels were higher than in the intensive care group, of course it was blinded at that point. But there's a whole point here is, in your paper you show an increase in the statin proportion, which is higher in the placebo group compared with the metformin and your intensive lifestyle, significantly so for the lifestyle one. So I'm just wondering whether even the low power was further blunted by the drop in effects of these other medications. Dr. Ronald Goldberg: Thanks very much for those comments guys, I think they're spot on. Let me first respond Hertzel with my thoughts on this, and then go over to your point, Rury. I think it's really interesting to look back over time and realize how much medical management has changed. And that goes right to your point, Rury, that doing a clinical trial like this where the primary care physicians are informed about what we're doing, what... communicated with on a regular basis, particularly when their patients develop diabetes, it just heightens the entire level of medical management. And I think you're absolutely right, but it's interesting to see what's happened to cardiovascular disease over the last 25 years, both in the general population and in the prediabetic population, the risk of cardiovascular disease has gone down. And then on top of that, we've got this very intensive cardio prevention intervention by primary care physicians, with high rates of statin usage, high rates of any hypertensive treatment, even the placebo group to your question, really lost weight. Dr. Ronald Goldberg: And they knew full well what was... and this was a very hands on type of study where our participants were really followed now for all these years, really became integrated with the research team. And so everybody knew what everybody else was doing. And so I'm sure the placebo effect was very strong, but I think nevertheless... Oh, and the last point I wanted to make was of course, the severity of the diabetes, even though 60% are developed diabetes, the severity of the diabetes was relatively mild. Even in those who developed diabetes, we know their average A1C was only about 6.7. And so I think that has a lot to do with blunting the acceleration effect of diabetes on cardiovascular disease. So, I think all of these factors contributed together to produce a negative result. But I think an important message, nevertheless. Dr. Hertzel Gerstein: I can highlight that point, that Ron was saying is that if diabetes prevention is going to prevent cardiovascular outcomes, it's going to do that because of a difference in glycemic exposure. The diabetes is by definition a disease of an elevated blood sugar. So if diabetes prevention prevents cardio, it means that the blood sugar's going to be lower than it would otherwise be. So if there's very little difference over the long term follow up in blood sugar because of co-intervention and therapy of all the treatment groups, then that would eliminate a lot of the benefits of diabetes prevention, because these are patients who are in this trial, who are being scrutinized even more than they would be if they were out there free range without being involved in any follow up. So, that's a spot on point. Rury, you wanted to comment. Dr. Rury Holman: Yeah. So, Hertzel just to expand on that. Obviously the glycemic impact on macrovascular disease is relatively modest compared to the impact on microvascular disease, which of course is what we all saw originally with type 2 diabetes. In fact, in KPDS35, when we looked or calculated what 1% reduction in A1C would do, it would only reduce stroke or MI by about 12 to 14%. So it's quite a shallow slope if you like. And your point is spot on is if that glucose levels are kept low by good treatment and good management role tell us about the great team they have. Then there was no room for a glycemic impact in this particular study. It's another question, whether you think metformin acts by different mechanisms to reduce cardiovascular disease, that's another question I had for Ron that he might like to address, is if there was a magic effect of metformin, why didn't we see that? Dr. Ronald Goldberg: And that's a really interesting question, Rury, because you may be aware that we published a paper a few years ago on our assessment of coronary calcification in a subgroup, in about 60% of the population who agreed to do this and who were eligible. And interestingly found that metformin did was accompanied by a reduction in the prevalence of coronary calcium in men, not women. Dr. Ron Goldberg: And the effect was actually when we did subgroup analysis, we found it was particularly strong in young men. And actually that gave us some sense of optimism that we might see something when we came to actual events. And of course, as you all know, metformin has beneficial effects on several cardiovascular risk factors. And so the question is whether there is some effect of metformin that might yet be identified, a coronary calcium after all is a surrogate of events and may take time, or it may be that... And we are really interested in the idea that both prediabetes and diabetes are heterogeneous. There's more and more interest in looking at subgroups of individuals who may be more predisposed. And it may be that metformin might have beneficial effects in some of those subgroups. Dr. Hertzel Gerstein: But also remember on the other hand, there was a lot of co-intervention with metformin in all groups after the trial was over. So all groups were offered metformin, et cetera. So even if metformin had an effect, it could have easily been washed out by the exposure of all the other groups to metformin during follow up. But Ron, you also touched on both the hope and the frustration too, because if we start thinking about subgroups, we can always think of subgroups. Yeah. But then the problem with subgroups is you have a study, let's say you have a cohort study with 7,000 or 10,000 people and it followed for five years and, oh, well the effect isn't in all 10,000, it's only in 20% of them. So now you have a study of 2000 people, that's not enough to detect an effect in a subgroup. Dr. Hertzel Gerstein: So, subgroups just eat away at power in an exponential, not a linear way, so that you just rapidly lose any ability to detect anything. And so, yes, this is going to work in people with these three snips on this gene, in this subpopulation. Good luck, that's the difficulty and the challenge of... We need to find sometimes better or more efficient ways of identifying outcome protective therapies, because we can't keep drilling into some groups because we just don't have the resources to find it really. I don't know what other people feel about that, but. Dr. Carolyn Lam: I'm personally so enjoying this conversation as I know the audience is and we covered a lot. I'm sure everyone wants to pick up the paper and the editorial. Now, we talked about being underpowered for the number of studies. We talked about profitable dilution of things like statins, antihypertensive agents, even the crossover of potential treatment in the placebo arm and so on. And then we started talking about, or is it the how you got there and the drug that was used. And here, please don't shoot me, but I just know I have the answers on behalf of everyone else's thinking it. What do you say of people who go, "Well, it's because it's metformin. What if it was an SGLT2 inhibitor? What if it was a GLP-1 receptor agonist?" And as you know, a lot of people say those would in spite of the effect on glucose. Dr. Hertzel Gerstein: I can quickly jump in. It's very clear. We've learned this in the last 10 years, is that there are glucose lowering drugs and there are glucose lowering drugs with benefits. And the GLP-1 receptor agonist and the SGLT2 inhibitors are glucose lowering drugs with benefits. They lower glucose, but they seem to have a separate cardioprotective effect. And with the SGLT2 inhibitors that cardioprotective effect does not seem to be related to the glucose lowering. There are a few meta regression analyses that suggest that with the GLP-1 receptor agonist, part of the cardioprotective effect is related to glucose lowering and part is not. And clearly mediation analysis with some of the trials have shown the same thing with the GLP-1 receptor agonist, not really with the SGLT2 inhibitors. So, maybe, that's my spin on this. Dr. Carolyn Lam: Dr. Holman. Dr. Rury Holman: Yeah. I was going to echo what Hertzel said in that regard, these other agents do have multiple effects. They change weight, they change blood pressure. And so other risk factors are brought into play other than glucose lowerings. We've already agreed, glucose lowering impact on cardiovascular disease is quite modest. I'd rather have it than not, but it wouldn't be my primary way to treat cardiovascular disease. And coming back to Ron's study, which is crucial today, the issue here is whether we could untangle an impact particularly of metformin, which has been foundation drug for type 2 diabetes for so long. Dr. Rury Holman: But clearly within the dataset we have here, underpowered it is. There are no clear messages in that respect, which is disappointing, but it doesn't mean that there isn't an effect. With longer follow up, with more data than you might see it. When the study... I'm coming for you Hertzel, was stopped for futility then the hazard ratio has changed, that often the way, not for the right way, but it's often what happens when you stop studies. I wondered if you wanted to comment on that aspect, because I know it's something that you've talked a lot about. Dr. Carolyn Lam: Dr. Gerstein. Did you want to? Dr. Hertzel Gerstein: I agree with what Rury said. I think the point you're making Rury goes back to power, and the ability to have enough people and enough events to detect and effect and that's clearly true, so... Dr. Carolyn Lam: Well, I hate to be the one to break the party up, but we have gone over time and intentionally so, there's just so much learning here. But Dr. Goldberg, could I give you the last say please? What do you think is the important clinical take home message of your paper? Dr. Ron Goldberg: Well, I think that the fact that we demonstrated that our study has been able to maintain really low levels of cardiovascular risk factors, low levels of A1C, even though that likely contributed to the negative finding still leaves the physician where the recognition that it is important to identify individuals with prediabetes to Institute Diabetes Prevention Programs, because I think it's entirely possible as I said earlier, and we've begun to identify them, subgroups of individuals who do progress more rapidly and who do warrant a more effective treatment, which would come from an early intervention program. Dr. Carolyn Lam: Wow. Thank you so, so much for that. Thank you so much. All three gentlemen for this amazing discussion. Well, audience, you heard it right here on Circulation on the Run from Greg and I thank you for joining us today and don't forget to tune in again next week. Speaker 6: This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ahajournals.org.

Daily News Brief for Wednesday May 4th, 2022 Plug Do you have a podcast, or are you thinking about starting one? Does your church have a podcast feed for sermons? The Dropwave.io is for you. Cancel culture is like walking on a thin glass bridge over the Grand Canyon. Every step you take could get you killed, I mean canceled. Since the beginning CrossPolitic has been working on being antifragile, so no matter what happens, our content can still be delivered to your tv and to your podcast. This past year, the Waterboy and his friend Jeremi, have been working on building a podcast hosting solution for rowdy platforms like CrossPolitic, so that you can be confident your podcast will never fall through that glass bridge. Dropwave offers seamless onboarding for shows that have been around for years to easy to use solutions for starting your own podcast. Dropwave will track all your show’s downloads by city, state, and country, and it offers network and enterprise packages for solutions like the Fight Laugh Feast Network. Free to speak, Free to podcast, free to start your journey now at www.Dropwave.io. Supreme Court has voted to overturn abortion rights, draft opinion shows https://www.politico.com/news/2022/05/02/supreme-court-abortion-draft-opinion-00029473 As you are aware by now, Politico released a leaked “The Supreme Court has voted to strike down the landmark Roe v. Wade decision, according to an initial draft majority opinion written by Justice Samuel Alito circulated inside the court and obtained by POLITICO. The draft opinion is a full-throated, unflinching repudiation of the 1973 decision which guaranteed federal constitutional protections of abortion rights and a subsequent 1992 decision — Planned Parenthood v. Casey — that largely maintained the right. “Roe was egregiously wrong from the start,” Alito writes. “We hold that Roe and Casey must be overruled,” he writes in the document, labeled as the “Opinion of the Court.” “It is time to heed the Constitution and return the issue of abortion to the people’s elected representatives.” Deliberations on controversial cases have in the past been fluid. Justices can and sometimes do change their votes as draft opinions circulate and major decisions can be subject to multiple drafts and vote-trading, sometimes until just days before a decision is unveiled. The court’s holding will not be final until it is published, likely in the next two months. The immediate impact of the ruling as drafted in February would be to end a half-century guarantee of federal constitutional protection of abortion rights and allow each state to decide whether to restrict or ban abortion. It’s unclear if there have been subsequent changes to the draft.” Was the Constitution silent on abortion and does tradition make room for abortion being legal? More from Politico on this: “The inescapable conclusion is that a right to abortion is not deeply rooted in the Nation’s history and traditions,” Alito writes. Much of Alito’s draft is devoted to arguing that widespread criminalization of abortion during the 19th and early 20th century belies the notion that a right to abortion is implied in the Constitution. The conservative justice attached to his draft a 31-page appendix listing laws passed to criminalize abortion during that period. Alito claims “an unbroken tradition of prohibiting abortion on pain of criminal punishment…from the earliest days of the common law until 1973.” “Until the latter part of the 20th century, there was no support in American law for a constitutional right to obtain an abortion. Zero. None. No state constitutional provision had recognized such a right,” Alito adds. Alito who wrote the majority opinion in this draft, according to Politico, had a number of sharp things to say: “At times, Alito’s draft opinion takes an almost mocking tone as it skewers the majority opinion in Roe, written by Justice Harry Blackmun, a Richard Nixon appointee who died in 1999. “Roe expressed the ‘feel[ing]’ that the Fourteenth Amendment was the provision that did the work, but its message seemed to be that the abortion right could be found somewhere in the Constitution and that specifying its exact location was not of paramount importance,” Alito writes. Alito declares that one of the central tenets of Roe, the “viability” distinction between fetuses not capable of living outside the womb and those which can, “makes no sense.” “The Constitution does not prohibit the citizens of each State from regulating or prohibiting abortion,” the draft concludes. “Roe and Casey arrogated that authority. We now overrule those decisions and return that authority to the people and their elected representatives.” Here is my two cents on this: First, leaks happen for a reason, and this leak is egregious intentional. The abortion culture will do anything to keep their blood sacrifice, and that is the whole point of this leak. Secondly, since the leak was intentional, here are the chess pieces they are trying to influence. Option 1: Get one (or two, we dont know) Justices to change their position in the next two months. Option 2: If one of the Justices get suicided before the vote is finalized, then the decision will go in favor of the blood sacrifice crowd. Option 3: Try and get everyone to rally in the November elections, and stave off a Republican wave…sort of the COVID effect. Create chaos, which democrats just love, just look at their cities, and steal the election in November. Third thing to consider here. Chief Justice John Roberts has ordered an investigation into the leak, so this letter is probably pretty accurate with the direction the ruling was/is going, and the word on the street was that it was Amit Jain clerks for Supreme Court Justice Sonia Sotomayor leaked the draft (https://twitter.com/MattWolking/status/1521303528421171203?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1521303528421171203%7Ctwgr%5E%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fwww.lifenews.com%2F2022%2F05%2F03%2Fif-justice-sonia-sotomayor-was-involved-in-supreme-court-leak-she-should-be-impeached%2F). Matt Woking, Republican advisor and strategist, connected some dots on Twitter last night and said that “As a Yale student, Jain blasted Yale for supporting Brett Kavanaugh's nomination. Jain was quoted in a 2017 Politico piece by Josh Gerstein. Today, Gerstein published the draft SCOTUS opinion on Roe.” If this leak came from Sotomayor’s office, she should be impeached after November, and replaced by a Republican House and Senate. Well here is Biden’s Statement on this leak and draft decision: COVID Science has wrecked our industrial medical complex. No one trusts their “science” anymore and so guys like Dr. Jay and others are working hard to be trusted voices in the midst of all this confusion. Dr. Martin Kulldorf, Epidemiologist, Biostatistician, and Former Harvard Professor of Medicine released the “Twelve Forgotten Principles of Public Health”, and they are: #1 Public health is about all health outcomes, not just a single disease like #COVID19. It is important to also consider harms from public health measures. #2 Public health is about the long term rather than the short term. Spring #COVID19 #lockdowns simply delayed and postponed the pandemic to the fall. #3 Public health is about everyone. It should not be used to shift the burden of disease from the affluent to the less affluent, as the #COVID19 #lockdowns have done. #4 Public health is global. Public health scientists need to consider the global impact of their recommendations. #5 Risks and harms cannot be completely eliminated, but they can be reduced. Elimination and zero-COVID strategies backfire, making things worse. #6 Public health should focus on high-risk populations. For #COVID19, many standard public health measures were never used to protect high-risk older people, leading to unnecessary deaths. #7 While contact tracing and isolation is critically important for some infectious diseases, it is futile and counterproductive for common infections such as influenza and #COVID19. #8 A case is only a case if a person is sick. Mass testing asymptomatic individuals is harmful to public health. #9 Public health is about trust. To gain the trust of the public, public health officials and the media must be honest and trust the public. Shaming and fear should never be used in a pandemic. #10 Public health scientists and officials must be honest with what is not known. For example, epidemic models should be run with the whole range of plausible input parameters. #11 In public health, open civilized debate is profoundly critical. Censoring, silencing and smearing leads to fear of speaking, herd thinking and distrust. #12 It is important for public health scientists and officials to listen to the public, who are living the public health consequences. This pandemic has proved that many non-epidemiologists understand public health better than some epidemiologists. / END New study: Face mask usage correlates with higher death rates https://www.israelnationalnews.com/news/326734 According to Israel National News: A new peer-reviewed study entitled: "Correlation Between Mask Compliance and COVID-19 Outcomes in Europe" has demonstrated that use of face masks, even widespread, did not correlate with better outcomes during the COVID epidemic, based on data from 35 European countries with populations of over one million people each, encompassing a total of 602 million people. The study noted that the average proportion of mask usage in the period investigated (October 2020 until March 2021) was 60.9% ± 19.9%. Governments and advisory bodies have recommended and often mandated the wearing of face masks in public spaces and in many areas mandates or recommendations remain in place, despite the fact, the study notes, that randomized controlled trials from prior to and during the epidemic have failed to show a benefit to the wearing of such masks with regard to COVID transmission. "Positive correlation between mask usage and cases was not statistically significant," the study also found, "while the correlation between mask usage and deaths was positive and significant (rho = 0.351, p = 0.039)." That is to say, more mask usage correlated with a higher death rate. The study used a variety of statistical methods to study correlation but "none of these tests provided negative correlations between mask usage and cases/deaths ... Surprisingly, weak positive correlations were observed when mask compliance was plotted against morbidity (cases/million) or mortality (deaths/million) in each country." The study also noted that the public may have gained the impression that masks could be helpful due to the fact that mandates were usually implemented after the first peak of COVID cases had passed. However, it became evident that masks were not in fact helpful later that same year, when widespread mask usage does not appear to have mitigated the severity of the COVID wave of winter 2020. "Moreover," the study concludes, "the moderate positive correlation between mask usage and deaths in Western Europe also suggests that the universal use of masks may have had harmful unintended consequences." Elon Musk goes scorched-earth on NBC after Peacock host's attack, notes network's worst scandals https://www.foxnews.com/media/elon-musk-scorched-earth-nbc-peacock-host-insults-notes-networks-worst-scandals?intcmp=fb_fnc According to Fox News: Tesla CEO Elon Musk took a scorched-earth approach to NBC on Monday after a left-wing Peacock host accused him of handing Twitter "to the far-right." "NBC basically saying Republicans are Nazis …" Musk wrote in a Monday tweet, responding to a video clip posted by another user showing Mehdi Hasan railing against Musk, calling him a "not-so-bright billionaire," and complaining about his purchase of the social media giant. "Same org that covered up Hunter Biden laptop story, had Harvey Weinstein story early & killed it & built Matt Lauer his rape office. Lovely people," Musk added in another tweet, listing some of the network's most notorious scandals in recent years. This is Gabriel Rench with Crosspolitic News. Support Rowdy Christian media by joining our club at fightlaughfeast.com, downloading our App, and head to our annual Fight Laugh Feast Events. If this content is helpful to you, would you please consider becoming a Fight Laugh Feast Club Member? We are trying to build a cancel-proof media platform, and we need your help. Join today and get a discount at the Fight Laugh Feast conference in Knoxville, TN and have a great day. Have a great day. Lord bless

Daily News Brief for Wednesday May 4th, 2022 Plug Do you have a podcast, or are you thinking about starting one? Does your church have a podcast feed for sermons? The Dropwave.io is for you. Cancel culture is like walking on a thin glass bridge over the Grand Canyon. Every step you take could get you killed, I mean canceled. Since the beginning CrossPolitic has been working on being antifragile, so no matter what happens, our content can still be delivered to your tv and to your podcast. This past year, the Waterboy and his friend Jeremi, have been working on building a podcast hosting solution for rowdy platforms like CrossPolitic, so that you can be confident your podcast will never fall through that glass bridge. Dropwave offers seamless onboarding for shows that have been around for years to easy to use solutions for starting your own podcast. Dropwave will track all your show’s downloads by city, state, and country, and it offers network and enterprise packages for solutions like the Fight Laugh Feast Network. Free to speak, Free to podcast, free to start your journey now at www.Dropwave.io. Supreme Court has voted to overturn abortion rights, draft opinion shows https://www.politico.com/news/2022/05/02/supreme-court-abortion-draft-opinion-00029473 As you are aware by now, Politico released a leaked “The Supreme Court has voted to strike down the landmark Roe v. Wade decision, according to an initial draft majority opinion written by Justice Samuel Alito circulated inside the court and obtained by POLITICO. The draft opinion is a full-throated, unflinching repudiation of the 1973 decision which guaranteed federal constitutional protections of abortion rights and a subsequent 1992 decision — Planned Parenthood v. Casey — that largely maintained the right. “Roe was egregiously wrong from the start,” Alito writes. “We hold that Roe and Casey must be overruled,” he writes in the document, labeled as the “Opinion of the Court.” “It is time to heed the Constitution and return the issue of abortion to the people’s elected representatives.” Deliberations on controversial cases have in the past been fluid. Justices can and sometimes do change their votes as draft opinions circulate and major decisions can be subject to multiple drafts and vote-trading, sometimes until just days before a decision is unveiled. The court’s holding will not be final until it is published, likely in the next two months. The immediate impact of the ruling as drafted in February would be to end a half-century guarantee of federal constitutional protection of abortion rights and allow each state to decide whether to restrict or ban abortion. It’s unclear if there have been subsequent changes to the draft.” Was the Constitution silent on abortion and does tradition make room for abortion being legal? More from Politico on this: “The inescapable conclusion is that a right to abortion is not deeply rooted in the Nation’s history and traditions,” Alito writes. Much of Alito’s draft is devoted to arguing that widespread criminalization of abortion during the 19th and early 20th century belies the notion that a right to abortion is implied in the Constitution. The conservative justice attached to his draft a 31-page appendix listing laws passed to criminalize abortion during that period. Alito claims “an unbroken tradition of prohibiting abortion on pain of criminal punishment…from the earliest days of the common law until 1973.” “Until the latter part of the 20th century, there was no support in American law for a constitutional right to obtain an abortion. Zero. None. No state constitutional provision had recognized such a right,” Alito adds. Alito who wrote the majority opinion in this draft, according to Politico, had a number of sharp things to say: “At times, Alito’s draft opinion takes an almost mocking tone as it skewers the majority opinion in Roe, written by Justice Harry Blackmun, a Richard Nixon appointee who died in 1999. “Roe expressed the ‘feel[ing]’ that the Fourteenth Amendment was the provision that did the work, but its message seemed to be that the abortion right could be found somewhere in the Constitution and that specifying its exact location was not of paramount importance,” Alito writes. Alito declares that one of the central tenets of Roe, the “viability” distinction between fetuses not capable of living outside the womb and those which can, “makes no sense.” “The Constitution does not prohibit the citizens of each State from regulating or prohibiting abortion,” the draft concludes. “Roe and Casey arrogated that authority. We now overrule those decisions and return that authority to the people and their elected representatives.” Here is my two cents on this: First, leaks happen for a reason, and this leak is egregious intentional. The abortion culture will do anything to keep their blood sacrifice, and that is the whole point of this leak. Secondly, since the leak was intentional, here are the chess pieces they are trying to influence. Option 1: Get one (or two, we dont know) Justices to change their position in the next two months. Option 2: If one of the Justices get suicided before the vote is finalized, then the decision will go in favor of the blood sacrifice crowd. Option 3: Try and get everyone to rally in the November elections, and stave off a Republican wave…sort of the COVID effect. Create chaos, which democrats just love, just look at their cities, and steal the election in November. Third thing to consider here. Chief Justice John Roberts has ordered an investigation into the leak, so this letter is probably pretty accurate with the direction the ruling was/is going, and the word on the street was that it was Amit Jain clerks for Supreme Court Justice Sonia Sotomayor leaked the draft (https://twitter.com/MattWolking/status/1521303528421171203?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1521303528421171203%7Ctwgr%5E%7Ctwcon%5Es1_&ref_url=https%3A%2F%2Fwww.lifenews.com%2F2022%2F05%2F03%2Fif-justice-sonia-sotomayor-was-involved-in-supreme-court-leak-she-should-be-impeached%2F). Matt Woking, Republican advisor and strategist, connected some dots on Twitter last night and said that “As a Yale student, Jain blasted Yale for supporting Brett Kavanaugh's nomination. Jain was quoted in a 2017 Politico piece by Josh Gerstein. Today, Gerstein published the draft SCOTUS opinion on Roe.” If this leak came from Sotomayor’s office, she should be impeached after November, and replaced by a Republican House and Senate. Well here is Biden’s Statement on this leak and draft decision: COVID Science has wrecked our industrial medical complex. No one trusts their “science” anymore and so guys like Dr. Jay and others are working hard to be trusted voices in the midst of all this confusion. Dr. Martin Kulldorf, Epidemiologist, Biostatistician, and Former Harvard Professor of Medicine released the “Twelve Forgotten Principles of Public Health”, and they are: #1 Public health is about all health outcomes, not just a single disease like #COVID19. It is important to also consider harms from public health measures. #2 Public health is about the long term rather than the short term. Spring #COVID19 #lockdowns simply delayed and postponed the pandemic to the fall. #3 Public health is about everyone. It should not be used to shift the burden of disease from the affluent to the less affluent, as the #COVID19 #lockdowns have done. #4 Public health is global. Public health scientists need to consider the global impact of their recommendations. #5 Risks and harms cannot be completely eliminated, but they can be reduced. Elimination and zero-COVID strategies backfire, making things worse. #6 Public health should focus on high-risk populations. For #COVID19, many standard public health measures were never used to protect high-risk older people, leading to unnecessary deaths. #7 While contact tracing and isolation is critically important for some infectious diseases, it is futile and counterproductive for common infections such as influenza and #COVID19. #8 A case is only a case if a person is sick. Mass testing asymptomatic individuals is harmful to public health. #9 Public health is about trust. To gain the trust of the public, public health officials and the media must be honest and trust the public. Shaming and fear should never be used in a pandemic. #10 Public health scientists and officials must be honest with what is not known. For example, epidemic models should be run with the whole range of plausible input parameters. #11 In public health, open civilized debate is profoundly critical. Censoring, silencing and smearing leads to fear of speaking, herd thinking and distrust. #12 It is important for public health scientists and officials to listen to the public, who are living the public health consequences. This pandemic has proved that many non-epidemiologists understand public health better than some epidemiologists. / END New study: Face mask usage correlates with higher death rates https://www.israelnationalnews.com/news/326734 According to Israel National News: A new peer-reviewed study entitled: "Correlation Between Mask Compliance and COVID-19 Outcomes in Europe" has demonstrated that use of face masks, even widespread, did not correlate with better outcomes during the COVID epidemic, based on data from 35 European countries with populations of over one million people each, encompassing a total of 602 million people. The study noted that the average proportion of mask usage in the period investigated (October 2020 until March 2021) was 60.9% ± 19.9%. Governments and advisory bodies have recommended and often mandated the wearing of face masks in public spaces and in many areas mandates or recommendations remain in place, despite the fact, the study notes, that randomized controlled trials from prior to and during the epidemic have failed to show a benefit to the wearing of such masks with regard to COVID transmission. "Positive correlation between mask usage and cases was not statistically significant," the study also found, "while the correlation between mask usage and deaths was positive and significant (rho = 0.351, p = 0.039)." That is to say, more mask usage correlated with a higher death rate. The study used a variety of statistical methods to study correlation but "none of these tests provided negative correlations between mask usage and cases/deaths ... Surprisingly, weak positive correlations were observed when mask compliance was plotted against morbidity (cases/million) or mortality (deaths/million) in each country." The study also noted that the public may have gained the impression that masks could be helpful due to the fact that mandates were usually implemented after the first peak of COVID cases had passed. However, it became evident that masks were not in fact helpful later that same year, when widespread mask usage does not appear to have mitigated the severity of the COVID wave of winter 2020. "Moreover," the study concludes, "the moderate positive correlation between mask usage and deaths in Western Europe also suggests that the universal use of masks may have had harmful unintended consequences." Elon Musk goes scorched-earth on NBC after Peacock host's attack, notes network's worst scandals https://www.foxnews.com/media/elon-musk-scorched-earth-nbc-peacock-host-insults-notes-networks-worst-scandals?intcmp=fb_fnc According to Fox News: Tesla CEO Elon Musk took a scorched-earth approach to NBC on Monday after a left-wing Peacock host accused him of handing Twitter "to the far-right." "NBC basically saying Republicans are Nazis …" Musk wrote in a Monday tweet, responding to a video clip posted by another user showing Mehdi Hasan railing against Musk, calling him a "not-so-bright billionaire," and complaining about his purchase of the social media giant. "Same org that covered up Hunter Biden laptop story, had Harvey Weinstein story early & killed it & built Matt Lauer his rape office. Lovely people," Musk added in another tweet, listing some of the network's most notorious scandals in recent years. This is Gabriel Rench with Crosspolitic News. Support Rowdy Christian media by joining our club at fightlaughfeast.com, downloading our App, and head to our annual Fight Laugh Feast Events. If this content is helpful to you, would you please consider becoming a Fight Laugh Feast Club Member? We are trying to build a cancel-proof media platform, and we need your help. Join today and get a discount at the Fight Laugh Feast conference in Knoxville, TN and have a great day. Have a great day. Lord bless

Daniel M. Gerstein is a senior policy researcher at the RAND Corporation. Previously, he served at the U.S. Department of Homeland Security (DHS) as under secretary (Acting) and deputy under secretary in the Science & Technology Directorate. He has extensive experience in security and defense while serving as a Senior Executive Service (SES) government civilian, in uniform, and in industry. He is also an adjunct professor at American University in Washington, D.C. --- Support this podcast: https://anchor.fm/out-of-the-blank-podcast/support

In This EpisodeYou'll hear JCK editor-in-chief Victoria Gomelsky and news director Rob Bates talk with Beth Gerstein, cofounder and CEO of Brilliant Earth.Show Notes00:30 Victoria and Rob introduce their guest Beth Gerstein, cofounder and CEO of Brilliant Earth08:30 Beth explains the importance of sustainability to the consumer14:11 Brilliant Earth offers both lab-grown and natural diamonds—Beth explains the difference19:10 Beth talks about Brilliant Earth's Fairmined collection23:16 Rob and Victoria wrap up the podcast with discussion of international plans, marketing to Gen Z versus millennials, Russian diamonds, and brick-and-mortar stores and online salesEpisode CreditsHosts: Rob Bates and Victoria GomelskyProducer and engineer: Natalie ChometPlugs: brilliantearth.com, jckonline.com, @jckmagazineShow RecapIntroducing Beth GersteinVictoria and Rob introduce their guest Beth Gerstein, cofounder and CEO of Brilliant Earth in San Francisco. Victoria mentions that Brilliant Earth is really leading the charge on sustainability and ethical sourcing. As always, the JCK editors dive into Beth's background and how she got into the jewelry industry. Beth grew up in Maryland, and both of her parents worked in government. She studied biomedical engineering and did work launching satellites, but Beth eventually realized her heart was in business and switched industries entirely.The Importance of SustainabilityBeth explains how she developed Brilliant Earth on a set of values revolving around sustainability and ethical sourcing. With diamonds being such an emotional purchase, she believed people would want to know about the sourcing of their stones. She says Brilliant Earth's customers don't want to compromise on quality, design, or experience—but transparency is extremely important. The company recently released its sustainability report, and she wants the industry to continue to do this difficult work. Beth also confirms that it's been six months since Brilliant Earth went public. She says it helps them to set clear objectives and have financial discipline.Lab-Grown DiamondsVictoria and Rob have questions for Beth about lab-grown versus mined diamonds, and Beth says that there's space for both—it opens the market more. Brilliant Earth started offering lab-grown 10 years ago and sees continued success with their sale. As a retailer, she says it's Brilliant Earth's responsibility to be open about its sources for both conflict-free and lab-grown diamonds. Beth says typically the younger shopper tends to gravitate more toward lab-grown diamonds. Victoria asks about a lack of transparency when it comes to lab-grown diamond sourcing.Brilliant Earth's Fairmined CollectionVictoria asks Beth about Brilliant Earth's new Fairmined gold collection, and Beth says she developed the collection with its customers in mind. She's happy to be able to support artisanal and small-scale miners who are getting a fair price for their gold. She believes Fairmined gold will only grow in popularity. Victoria also asks if Beth goes to shows like JCK—and Beth has met many great suppliers since the first show. Rob asks what the most important thing about building a brand is, and Beth says it's building a connection to the customers.International Plans, Gen Z Versus Millennials, and Russian DiamondsRob asks Beth if Brilliant Earth plans to make a push internationally at some point, and she says yes. It's already shipping to more than 50 countries. Victoria asks about Gen Z and how they differ from millennials. Gen Z is social first, and Beth says it's important to talk to customers where they are. She also says she values authenticity, inclusivity, and expects sustainability. Brilliant Earth has also recently removed Russian diamonds from their site.(Photo courtesy of Beth Gerstein)

Welcome to SMART Talk! In this episode Arthur and I spoke with Joe Gerstein, founding President and a current Board Member for SMART Recovery. Joe has facilitated SMART Recovery meetings since its inception. He has developed many of the tools in the SMART toolbox and he helped start SMART meetings in several countries around the […]

David Gerstein:  Iconic Global Artist Does Art His Way David Gerstein teaches us the lesson of not going with the herd.  No matter what others tell you -- stick to your inner voice.  You have seen his enormous playful vibrant metal sculptures in train stations and parks all over the world -- from China to the USA.   David considers his childhood in the 1950s as the cornerstone of his work.  Today, he shares his philosophy of sticking to your instinct as an artist.  Stories of financial struggles during his life in New York City in the 1970s punctuate the sweetness of his success at 76 years old.  Join me for this inspiring story; it's the best twenty minutes you'll spend today.Please do three things: Subscribe to our podcast through your favorite platform.Share this episode with a few of your friends today.Visit our website at http://findinginspiration.lifeIn this episode we cover:Born in 1944, David was not an overnight sensation.  He built his reputation slowly and with intention.  Friends and family try to sway him from each medium he selected.  They call out how unpopular his plan was but David would not change his mind. For 8 years he struggled with new things he did in sculpture.   He ignored what everyone else said about quitting. David shares the advice he gives young artists today.  "Go your own way."He believes, if you stick to your convictions ultimately people will find you. After traveling and studying around the world in his 20's, David returns to Israel.His time in NYC was interesting but full of suffering like only earning $40 per week.  David was penniless. He was the true example of a starving artist. At 50 years old, David became known around the world as a relevant artist.   He says talent is not enough -- "you have to insist" and contribute to the art world. Slowly he made his way into sculpture and it later became metal wall hangings he calls multiples and ultimately huge metal installations. Financial success came with his idea of creating playful bright colored metal cutouts or multiples. David realized he needed to be different since Israel wasn't close to the art centers of the world.  He needed to become noticed.  These multiples allowed David to have exhibitions all over the world at the same time.  He stood out from the crowded art world.  Later David created smaller multiples so everyday people had the chance to own his work.  These small multiples became his "Ambassadors" to the art world.  Packable art took the world by storm and David's popularity exploded from Singapore to Buenos Ares.  At 76 years old, David Gerstein still insists he go against the stream. Amazing Informative Links:https://davidgerstein.com/https://www.flickr.com/photos/time-to-look/47607202351https://www.artfixdaily.com/artwire/release/4998-david-gerstein-wallsculptures-at-galerie-frank-fluegelhttps://www.israel21c.org/10-eye-catching-sculptures-around-tel-aviv/ http://www.artnet.com/artists/david-gerstein/

On this episode of ActorSpeak, Austin Basis speaks with actor Ellen Gerstein (Shameless, Southland, James Dean, Seinfeld, Friends). In Part 1, we talk about being a social worker in NYC, sage advice from her therapist, studying with Lee Strasberg & Ernie Martin, script analysis with Stella Adler, trusting yourself, substitution, subtext improv, "if you don't need- don't use," behavior, and her teaching & coaching techniques. Ellen Gerstein is an award-winning Los Angeles filmmaker, actress, writer and director. She's a member of: Women In Film, The Alliance of Women Directors, Film Independent, and a lifetime member of The Actors Studio. As an actor, Ellen has worked with talented directors including Martin Scorsese, Mark Rydell, Mimi Leder, Rob Marshall, and Danny DeVito. Her TV credits include Law and Order True Crimes: The Menendez Murders, Southland and her recurring role on Shameless as Aunt Rande. Ellen starred in the award-winning feature film The Golden Age and in the short film Passage. Her acting work ranges from the comical to the poignant, working on shows like Better Things, The Morning Show and in the TNT movie James Dean. She played Aunt Lisa in Friends and Jerry's aunt in Seinfeld, so you've probably seen her talents grace your screen at one point or another. Ellen has also performed in multiple plays in Los Angeles and wrote & performed her one-woman show, My Psychotherapy Comeback Tour. Under the banner of Lulu Productions, Ellen has produced award-winning films, web series, music videos, documentaries, and theatre. She is currently developing several new projects, including Just South of Normal, a half-hour dramedy series in the vein of The Odd Couple about two high functioning men with developmental disabilities. I was lucky enough to participate in an early reading of this project, which was adapted from her award-winning short film Waiting For Ronald, with a blended cast of disabled and non-disabled actors. Come Away With Me, another film Ellen adapted, directed & acted in, has won over 15 awards and been in over 30 film festivals around the world- and was made with an all-female crew. What impresses me most about Ellen, besides her acting chops, is her persistent creative pursuits coupled with her warm welcoming spirit & sense of humor. Her passion for storytelling pushes her to constantly be creating new projects for her & her colleagues, and in turn, tell new stories. WE AUDITION is a video-chat community where actors can audition, self-tape, rehearse, and get expert industry advice. USE promo code: ACTORSPEAK to get 25% off when joining at WeAudition.com