POPULARITY
Categories
In this episode of the Epigenetics Podcast, we talked with Kunal Rai from MD Anderson Cancer Center about his work on active DNA demethylation and its role in cancer progression. A major part of the conversation covers his postdoctoral work on active DNA demethylation. He describes how he identified an AID-MBD4-based mechanism, later supported by GAD45, and how this work showed a role for DNA demethylation in early neuronal differentiation and in colon cancer initiation. We then discuss his move into his own lab and his work on melanoma progression. He explains how he used broad epigenomic profiling, chromatin state analysis, and 3D chromatin methods to study enhancers and chromatin organization, and how these approaches helped reveal changes linked to cancer progression. Another topic is his work on epigenetic regulators such as RNF2 and KMT2D. He describes findings on polycomb and trithorax-related factors, including tumor-suppressive roles for KMT2D in melanoma and lung cancer, and how KMT2D loss affects cell phenotype and metabolism. Finally, we talk about lab organization, collaboration, and newer technologies. He says his group works across multiple cancer types and increasingly includes immunology, single-cell methods, spatial epigenomics, and clinical translation, while still using ChIP-seq, CUT&RUN, and CUT&Tag where appropriate. References Fiziev, P., Akdemir, K. C., Miller, J. P., Keung, E. Z., Samant, N. S., Sharma, S., Natale, C. A., Terranova, C. J., Maitituoheti, M., Amin, S. B., Martinez-Ledesma, E., Dhamdhere, M., Axelrad, J. B., Shah, A., Cheng, C. S., Mahadeshwar, H., Seth, S., Barton, M. C., Protopopov, A., Tsai, K. Y., … Rai, K. (2017). Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression. Cell reports, 19(4), 875–889. https://doi.org/10.1016/j.celrep.2017.03.078 Terranova, C. J., Tang, M., Maitituoheti, M., Raman, A. T., Ghosh, A. K., Schulz, J., Amin, S. B., Orouji, E., Tomczak, K., Sarkar, S., Oba, J., Creasy, C., Wu, C. J., Khan, S., Lazcano, R., Wani, K., Singh, A., Barrodia, P., Zhao, D., Chen, K., … Rai, K. (2021). Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy. Cell reports, 36(3), 109410. https://doi.org/10.1016/j.celrep.2021.109410 Related Episodes Epigenetic Signatures During Aging and Cancer (Alena van Bömmel) Epigenetic Mechanisms in Breast Cancer (Luca Magnani) The Effect of Histone Demethylases on Gene Expression and Cancer Cell Stability (Johnathan Whetstine) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
What if, instead of asking "How can I make my money stretch further?" we started asking "How can I create more money?" In today's episode, we're heading down the money rabbit hole and looking at our current economy through a different lens. Yes, things are expensive. Inflation has changed what our dollars can buy, and when your income doesn't increase at the same pace, it can feel like you're constantly trying to do more with less. But here's the reframe: there isn't a shortage of money in the world. There are enormous amounts of money moving through the economy every single day. People are spending money to solve problems, save time, learn things, have experiences, buy products and make their lives easier. So how can you put yourself in the path of some of those dollars? In this episode, we're talking about: ✨ Why your paycheque doesn't have to be the ceiling on your income ✨ Shifting from "How much do I make?" to "How much could I create?" ✨ Simple products and services people are already willing to pay for ✨ Why you don't need to build a giant business to create another income stream ✨ Using the skills, knowledge, assets and resources you already have ✨ How creativity and manifestation work together when it comes to money ✨ Why inspired action matters just as much as an abundant mindset ✨ And the surprisingly brilliant money lesson my daughter taught me with a $50 Barbie house at a garage sale Her wallet said she couldn't afford it. Her brain said, "Okay…so how CAN I make this work?" And that might just be the energy we could all use a little more of. Your challenge after this episode: come up with 10 ways you could create money using something you already have access to. Your knowledge. Your skills. Your stuff. Your creativity. Your time. Your network. Don't just ask where more money is going to come from. Start asking: What value could I create that puts me in the path of money?
Schulz, Martin www.deutschlandfunkkultur.de, Studio 9
We explore and reflect on the Five Core Values of New Denver Church and how they inform our our life together as a community of faith. Download the Handout
Waldbrände, Niedrigwasser, Hitzetote: Das ist die Realität in diesem Sommer. SPD-Minister fordern deshalb Klimaanpassung im Grundgesetz zu verankern. Was bringt das? Außerdem: Baden als Kulturkampf. Warum das "Volksbad" in Berlin zum Politikum wurde Schulz, Josephine
Warum brauchen wir andere Menschen, um selbst aufzublühen? Leon und Atze schauen sich an, was die Forschung über soziale Unterstützung weiß: Wer hilft uns wobei am meisten – Freund:innen, Familie oder Kolleg:innen? Außerdem geht es darum, wie wir Freundschaften im Erwachsenenleben pflegen, warum ein gutes soziales Netz nicht möglichst groß sein muss – und wie schon kleine Momente der Verbindung einen Unterschied machen können. Eine Folge über das gute Gefühl: Wenn es darauf ankommt, ist jemand da. Fühlt euch gut betreut Leon & Atze Instagram: https://www.instagram.com/leonwindscheid/ https://www.instagram.com/atzeschroeder_offiziell/ Mehr zu unseren Werbepartnern findet ihr hier: https://linktr.ee/betreutesfuehlen Tickets: Atze: https://www.atzeschroeder.de/#termine Leon: https://leonwindscheid.de/tour/ Filmtipp: The banshees of Inisherin Quellen: Brown, S. L., Smith, D. M., Schulz, R., Kabeto, M. U., Ubel, P. A., Poulin, M., ... & Langa, K. M. (2009). Caregiving behavior is associated with decreased mortality risk. Psychological science, 20(4), 488-494. https://doi.org/10.1111/j.1467-9280.2009.02323.x Christakis, N. A., & Fowler, J. H. (2011). Connected: The surprising power of our social networks and how they shape our lives. Little, Brown and Company. Yeo, G., Lansford, J. E., & Rudolph, K. D. (2025). How does perceived social support relate to human thriving? A systematic review with meta-analyses. Psychological Bulletin, 151(9), 1089–1112. https://doi.org/10.1037/bul0000491 Centers for Disease Control and Prevention. Improving social connectedness. https://www.cdc.gov/social-connectedness/improving/index.html Reaktion: Julia Ditzer Produktion: Murmel Productions
Waldbrände, Niedrigwasser, Hitzetote: Das ist die Realität in diesem Sommer. SPD-Minister fordern deshalb Klimaanpassung im Grundgesetz zu verankern. Was bringt das? Außerdem: Baden als Kulturkampf. Warum das "Volksbad" in Berlin zum Politikum wurde Schulz, Josephine
Deutschland erkennt die Taliban als Regierung in Afghanistan nicht an, führt aber Gespräche, um abschieben zu können. Die Grünen-Politikerin Hannah Neumann sieht das kritisch. Deutschland lasse sich von den Taliban bei der Migration erpressen. Schulz, Josephine www.deutschlandfunk.de, Interviews
In der SPD wächst der Widerstand gegen die Wohngeldpläne der Bauministerin. Der Berliner SPD-Chef Steffen Krach wirft der schwarz-roten Bundesregierung vor, an der Lebensrealität der Bürger vorbeizuregieren. Schulz, Josephine www.deutschlandfunk.de, Interviews
In der SPD wächst der Widerstand gegen die Wohngeldpläne der Bauministerin. Der Berliner SPD-Chef Steffen Krach wirft der schwarz-roten Bundesregierung vor, an der Lebensrealität der Bürger vorbeizuregieren. Schulz, Josephine www.deutschlandfunk.de, Interviews
Der Klimawandel macht der Agrarwirtschaft in Deutschland zu schaffen. Seine Tiere stünden auf verdorrten Weiden, sagt der Milchbauer Ottmar Ilchmann. Dem Bauernverband wirft er vor, bei der Umsetzung von Lösungen auf der Bremse zu stehen. Schulz, Josephine www.deutschlandfunk.de, Informationen am Morgen
Deutschland erkennt die Taliban als Regierung in Afghanistan nicht an, führt aber Gespräche, um abschieben zu können. Die Grünen-Politikerin Hannah Neumann sieht das kritisch. Deutschland lasse sich von den Taliban bei der Migration erpressen. Schulz, Josephine www.deutschlandfunk.de, Interviews
Schulz, Josephine www.deutschlandfunk.de, Informationen am Morgen
What if one of the biggest keys to a healthy, meaningful retirement has nothing to do with money? Author and psychology professor Dr. Marc Schulz reveals why your relationships, social connections and "social fitness" may play a surprisingly important role in how well you age — and how you can strengthen them before and during retirement. In this episode, you'll learn: How retirement can disrupt your social network Ways introverts and extroverts can approach social fitness differently The "2 a.m. friend" test for evaluating your relationships How couples can navigate different social needs in retirement Dr. Schulz's practical 30-day social fitness challenge Listen in as Founder and CEO of Howard Bailey Financial, Casey Weade and Dr. Marc Schulz provide thoughtful insights and advice on how it applies to your unique financial situation. Show Notes: HowardBailey.com/581
Um eine AfD-Regierung zu verhindern, würde die Linke auch mit der CDU zusammenarbeiten. Aber die CDU hält am Unvereinbarkeitsbeschluss fest. Unglaubwürdig oder realitätsfern? Und: Kolumbien nach dem Erdbeben und im politischen Richtungswechsel. Schulz, Josephine
Um eine AfD-Regierung zu verhindern, würde die Linke auch mit der CDU zusammenarbeiten. Aber die CDU hält am Unvereinbarkeitsbeschluss fest. Unglaubwürdig oder realitätsfern? Und: Kolumbien nach dem Erdbeben und im politischen Richtungswechsel. Schulz, Josephine
"Echte Geheimdienste" oder neue Geheimpolizei? BND und Verfassungsschutz sollen künftig viel mehr dürfen - auch sabotieren, hacken und einbrechen. Mehr Sicherheit oder mehr Überwachungsstaat? Und: Was sich mit der BAföG-Reform für Studierende ändert. Schulz, Josephine
Das ganze Interview finden Sie hier: https://weltwoche.de/daily/afd-waehlen-wird-immer-normaler-journalistin-sophie-marie-schulz-ueber-podcaster-ben-berndt-deutschland-und-warum-sie-mit-allen-redet/ Unterstützen Sie die Weltwoche mit nur einem Klick: https://www.youtube.com/@die.weltwoche?sub_confirmation=1 Und aktivieren Sie die Glocke, damit Sie keine Sendung mehr verpassen. So helfen Sie mit, unser Programm weiter auszubauen. Herzlichen Dank! ⭐️ Weltwoche daily ohne externe Video-Werbung geniessen? Werden Sie Abonnent! ▶️ https://weltwoche.de/abonnemente/ «AfD wählen wird immer normaler»: Journalistin Sophie-Marie Schulz über Podcaster Ben Berndt, Deutschland und warum sie mit allen redet Kostenlos informiert:
"Echte Geheimdienste" oder neue Geheimpolizei? BND und Verfassungsschutz sollen künftig viel mehr dürfen - auch sabotieren, hacken und einbrechen. Mehr Sicherheit oder mehr Überwachungsstaat? Und: Was sich mit der BAföG-Reform für Studierende ändert. Schulz, Josephine
„Der Sinn des Lebens ist die Muße.“So die These Aristoteles' vor mehr als 2.000 Jahren. Und auch im antiken Ägypten waren Pausen fester Bestandteil des Arbeitsrhythmus. Während monumentale Werke wie die Pyramiden entstanden, saßen Menschen zwischendurch im Schatten der Bäume und erholten sich.Spulen wir vor: Aus dem Schattenplatz unter einem Baum ist ein Schreibtisch geworden, aus dem natürlichen Wechsel von Arbeit und Ruhe ein Kalender ohne Zwischenräume. Wir essen vor dem Bildschirm, springen von Termin zu Termin und nehmen die offene To-do-Liste gedanklich mit ins Bett.Wann wurde pausenloses Arbeiten eigentlich zum Zeichen besonderer Leistungsbereitschaft? Und wie können wir lernen, wieder richtig Pause zu machen?In dieser Folge von „New Work Meets Science“ spricht Dr. Theresa Fehn mit Dr. Johannes Wendsche, Arbeits- und Organisationspsychologe sowie Wissenschaftler bei der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin, über Pausen, Erholung und die Fähigkeit, nach der Arbeit wirklich abzuschalten.Wie lange sollte eine gute Pause dauern, wann brauchen wir sie und wo genau erholen wir uns am besten? Sollten Unternehmen bevorzugt Menschen einstellen, die nach Feierabend gut abschalten können? Oder eher diejenigen, deren Gedanken ständig um die Arbeit kreisen? Ist Detachment ein angeborenes Talent oder eine Fähigkeit, die wir trainieren können? Und was beeinflusst unser Abschalten stärker: unsere Persönlichkeit oder die Bedingungen, unter denen wir arbeiten?Johannes erklärt, warum Erholung eben kein Gegenpol zur Leistung ist, sondern eine Voraussetzung dafür, langfristig gesund und nachhaltig leistungsfähig zu bleiben. Es geht um Schlaf, Grübeln und Abgrenzungsrituale, um „maskierte Pausen“, Desk Detox und die Frage, warum uns in der Pause häufig genau das guttut, was bei der Arbeit zu kurz kommt.Außerdem geht es um praktische Tipps und Tricks: Was können wir selbst tun, um leichter abzuschalten? Wie können To-do-Listen, kurze Ortswechsel oder bewusst gesetzte Grenzen helfen? Und wie müssen Organisationen Arbeit gestalten, damit Beschäftigte sich tatsächlich erholen können?Eine Folge für alle, die Aristoteles' Kunst der Muße in den modernen Arbeitsalltag integrieren und Pausen gezielt für mehr Erholung, Konzentration und Leistungsfähigkeit nutzen möchten.Viel Spaß beim Hören!Foto: © IRIS FRIEDRICH PHOTOGRAPHYQuellen & Links: 4 Erholungsformen:Sonnentag, S., & Fritz, C. (2007). The Recovery Experience Questionnaire: Development and validation of a measure for assessing recuperation and unwinding from work. Journal of Occupational Health Psychology, 12(3), 204–221. https://doi.org/10.1037/1076-8998.12.3.204DRAMMA-Modell (6 Erholungsformen):Newman, D. B., Tay, L., & Diener, E. (2014). Leisure and subjective well-being: A model of psychological mechanisms as mediating factors. Journal of Happiness Studies, 15(3), 555–578. https://doi.org/10.1007/s10902-013-9492-1Zeigarnik Efffekt:Zeigarnik, B. (1927). Über das Behalten von erledigten und unerledigten Handlungen. Psychologische Forschung, 9, 1–85.Literatur-Tipps:Wendsche, J., Tschetsche, L., Lohmann-Haislah, A., Schulz, A., Schuller, K., & Schöllgen, I. (2025). Mentale Erholung von der Arbeit: Abschalten lernen (2. Aufl.). Bundesanstalt für Arbeitsschutz und Arbeitsmedizin. https://doi.org/10.21934/baua:praxis20250624Pang, A. S.-K. (2016). Rest: Why you get more done when you work less. Basic Books. Aktualisierte Ausgabe: Pang, A. S.-K. (2018). Rest: Why you get more done when you work less (Updated ed.). Basic Books.
Just five short months after Charles Schulz's passing, the top cartoonists in the field dedicated a day of their own strips to remembering Sparky. The gang looks at Peanuts tribute strips by Jim Davis (Garfield) Aaron McGruder (Boondocks) Cathy Guisewite (Cathy) and more. See the Go Comics article: https://www.gocomics.com/profile/OfficialGoComics/collections/44986 Transcript available at UnpackingPeanuts.com Jimmy's, Michael's, and Harold's books are available at UnpackingPeanuts.com/store. Unpacking Peanuts is copyright Jimmy Gownley, Michael Cohen, Harold Buchholz, and Liz Sumner. Produced and edited by Liz Sumner. Music by Michael Cohen. Additional voiceover by Aziza Shukralla Clark. For more from the show follow @unpackpeanuts on Instagram and Threads, and @unpackingpeanuts on Facebook, Blue Sky, and YouTube. For more about Jimmy, Michael, and Harold, visit unpackingpeanuts.com. Thanks for listening.
Schulz, Josephine www.deutschlandfunk.de, Wirtschaft und Gesellschaft
Johnny Mac reports on Christina P. (Christina Pazsitzky) and Tom Segura divorcing after nearly 20 years, with Christina confirming on Your Mom's House that it's sad but amicable, asking fans not to take sides, and saying they will continue co-hosting. The Times of London gives Dave Chappelle's London appearance two stars, criticizing a late start, high ticket prices, and an unfocused set that still touched on transgender-related material. Andrew Schulz comments on Caitlin Clark being criticized for avoiding politics. Stavros Halkias discusses playing a sous chef in an Anthony Bourdain movie. An LA Times feature covers Anthony Jeselnik's insomnia leading to the Jeselnik Book Club and its influence, with a nod to John Mulaney's book club. Jenny Yang tours grocery-store comedy shows, Mary Beth Barone discusses dating and crowd work, and Meredith Kercher's sister criticizes Amanda Knox's Edinburgh Fringe comedy project. 00:16 Christina P and Segura Split01:48 Chappelle London Review03:23 Schulz on Caitlin Clark04:02 Stavros in Bourdain Film04:50 Jeselnik Book Club Boom07:47 Jenny Yang Grocery Tour08:51 Mary Beth Barone Dating09:45 Amanda Knox Fringe Backlash Become a supporter of this podcast: https://www.spreaker.com/podcast/daily-comedy-news-with-johnny-mac--4522158/support.Daily Comedy News is hosted by Johnny Mac and releases every weekday. Subscribe on Spotify, Apple Podcasts, or your favorite app. Part of the Caloroga Shark Media network. For transcripts and show notes visit www.dailycomedynews.comDaily Comedy News with Johnny Mac is a daily podcast covering comedians, stand-up comedy, late night television, and the comedy industry. New episodes every morning. Follow on Apple Podcasts, Spotify, or wherever you listen. Contact John at John@thesharkdeck dot com For Uninterrupted Listening, use the Apple Podcast App and click the banner that says Uninterrupted Listening. $4.99/month John's Substack about media is free.
Ferencak, Leon; Schulz, Josephine; Schindler, Prof. Maike www.deutschlandfunk.de, Campus & Karriere
Schulz, Josephine www.deutschlandfunk.de, Campus & Karriere
Seit 1990 ist die Bevölkerung in Ostdeutschland um 16 Prozent geschrumpft. Besonders betroffen sind ländliche Gegenden. Kitas schließen und Busverbindungen werden gestrichen. Doch es gibt Ideen, um junge Familien wieder vom Dorfleben zu überzeugen. Schulz, Brigitte www.deutschlandfunkkultur.de, Zeitfragen. Feature
Schulz, Benedikt www.deutschlandfunk.de, Tag für Tag
Mehr Zäune, mehr Drohnen, mehr Befugnisse für Frontex: Nach dem Massenandrang in Ceuta einigt sich die EU auf Konsequenzen. Aber löst das die Probleme? Und: Die Regierung bereitet eine mögliche Wiedereinführung des Zivildienstes vor. Was hieße das? Schulz, Josephine
Rhein, Elbe, Donau: Überall Niedrigwasser. Die Folge: Atomkraftwerke müssen stoppen, Frachtschiffe fahren nicht oder laden weniger. Was tun? Und: Ist die Bahn zu teuer? Eine Studie zeigt: Die Werbung für Spartickets entspricht oft nicht der Realität. Schulz, Josephine
Infantinos Verkaufspläne der WM haben zu Boykottandrohungen geführt. Woher kommt der Aufstand gegen die Kommerzialisierung in der FIFA? Und: Zehntausende Flüchtlinge haben die spanische Exklave Ceuta erreicht. Was könnte zu dem Ansturm geführt haben? Schulz, Josephine
Friedrich Merz baut seine Machtzentrale um: Thorsten Frei wechselt vom Kanzleramt an die Spitze der Unionsfraktion. Glätten sich die Wogen jetzt wieder? Und: Auch für Deutschland wird ein Sexkaufverbot diskutiert. Wir blicken nach Schweden. Schulz, Sandra
Der Anschlag auf den CSD in Berlin hat neue Diskussionen um den Umgang mit Gefährdern entfacht, aber auch darüber, wie Menschen zu Gefährdern werden. Wie kann die Prävention gegen islamistische Radikalisierung funktionieren? Und: Während die Welt sich mit anderen Konflikten beschäftigt, geht der Krieg im Sudan weiter. Schulz, Josephine
Schulz, Josephine www.deutschlandfunk.de, Wirtschaft und Gesellschaft
En este EDN & Friends recibimos a Dani Schulz para hablar de cómo se aprende realmente a crear contenido en redes sociales y de cuáles han sido nuestras peores cancelaciones. Además, conversamos sobre lo mejor y lo peor de crecer en varios países y debatimos cómo debería distribuir los espacios de su casa una pareja con una relación sana.Síguenos en nuestras redes sociales:ESCUELA DE NADAInstagram: https://www.instagram.com/escueladenada/Twitter: https://twitter.com/escueladenadaTikTok: https://www.tiktok.com/@escueladenadaFacebook: https://www.facebook.com/escueladenada0:00 Intro3:03 ¿Un matrimonio sano debería tener cuartos separados?6:44 ¿Es mejor trabajar desde casa?9:59 ¿Los hombres son peores anfitriones que las mujeres?14:01 Lo mejor y lo peor de crecer en varios países18:55 Existen dos tipos de venezolanos22:49 ¿Migrar o asimilarse?27:35 Viajar te enriquece culturalmente28:56 El nuevo pobre30:41 Nueva Orleans es la ciudad de la locura34:40 Dani Schulz fue periodista deportiva38:06 ¿Cómo compite un creador de contenido contra la IA?42:46 ¿El término "influencer" solo tiene connotaciones negativas?46:00 Vivir buscando que te odien en internet47:20 Nuestra peor funa49:50 Solo aprendes a crear contenido creándolo53:55 Que te cancelen los planes es de lo peor55:10 ¿Cómo aprovecha Dani Schulz su tiempo libre?
Dan chats with Simon Nash about the upcoming grenache festival and the winery that we must put on the next itinerary to Barossa.Owned by an Argentinian and founded by the Schulz family in the mid 1800's and painstakingly restored, this is a must visit festival and winery.@thewineshowaustralia @alkinawine
Schulz, Josephine www.deutschlandfunk.de, Interviews
Die Waldbrände in Frankreich und Spanien spitzen sich zu. Vor allem der Klimawandel verbessere die Bedingungen für Feuer, so Feuerökologe Alexander Held. Es seien mehr präventive Maßnahmen notwendig, wie zum Beispiel den Faktor Biomasse zu reduzieren. Schulz, Josephine www.deutschlandfunk.de, Interviews
Die Bundesregierung will die Abschiebepraxis nach Afghanistan ausweiten. Amnesty International fordert hingegen einen generellen Abschiebestopp. Die Menschenrechtslage in dem Land sei weiterhin katastrophal, so Nina Alizadeh Marandi von Amnesty. Schulz, Josephine www.deutschlandfunk.de, Interviews
Schulz, Sandra www.deutschlandfunk.de, Interviews
Schulz, Benedikt www.deutschlandfunk.de, Tag für Tag
Die Menschen im Iran haben Angst vor einer Ausweitung des Krieges. Unser Korrespondent schildert den Alltag vor Ort. Und: Übernimmt KI die Macht? Modelle von OpenAI haben sich befreit, um zu hacken. Und: Thorsten Frei wird Unionsfraktionschef. Schulz, Josephine
Schulz, Josephine www.deutschlandfunk.de, Wirtschaft am Mittag
Köhler, Michael www.deutschlandfunk.de, Büchermarkt
Wie kommen wir von A nach B? Häufig genug eine quälende Frage, wenn die Bahn ausfällt oder im Stau kein Durchkommen ist. Wir sprechen über Macht, Mobilität und die Verkehrspolitik als Wahlkampffaktor in Berlin und Mecklenburg-Vorpommern. Schulz, Sandra
CDU-Politiker Jens Spahn hat lange die Leihmutterschaft kritisiert, ist nun aber selbst so Vater geworden. Viele fordern seinen Rücktritt. Außerdem: Die EU schwächt den Emissionshandel ab. Und: Das ZDF lädt Danger Dan aus. Ist das Cancel Culture? Schulz, Josephine
In 1980 Legendary Captain Marvel artist C.C. Beck created his personal list of “The Seven Deadly Sins of Comics Creators.” In this episode the gang discuss Beck's manifesto and see if and how it applies to Schulz's work. Shout out to TwoMorrows.com and AlterEgo for this article: https://www.twomorrows.com/alterego/articles/06sins.html Transcript available at UnpackingPeanuts.com Jimmy's, Michael's, and Harold's books are available at UnpackingPeanuts.com/store. Unpacking Peanuts is copyright Jimmy Gownley, Michael Cohen, Harold Buchholz, and Liz Sumner. Produced and edited by Liz Sumner. Music by Michael Cohen. Additional voiceover by Aziza Shukralla Clark. For more from the show follow @unpackpeanuts on Instagram and Threads, and @unpackingpeanuts on Facebook, Blue Sky, and YouTube. For more about Jimmy, Michael, and Harold, visit unpackingpeanuts.com. Thanks for listening.
Morgan Schulz returns to the show to break down an emotional HYROX World Championships in Stockholm.She shares the full story behind her asthma flare-up that forced her to withdraw from the Elite 15 singles race, the difficult decision to continue racing doubles the next day, and the medical issues she experienced after crossing the finish line.Morgan also talks about the support she received from fellow athletes, the challenge of balancing health with elite competition, her plans to get healthy for the fall season, and whether she and Kat will race the new Elite 15 series.Finally, we discuss the future of HYROX, race tickets and the Elite 15 license system, the Chicago Bears, true crime documentaries, and life away from racingLindsay BessegatoLindsay joins the show to talk about her journey from competitive hockey and CrossFit to becoming one of Canada's top HYROX athletes.She discusses qualifying for the Elite 15, representing Team Canada, working with coach Cole Sager, and why Miami was one of the toughest races of her career as she dealt with significant health challenges.Lindsay also opens up about years of underfueling, disordered eating, and the process of rebuilding her health while learning to fuel performance instead of chasing a certain body image. She explains how that has changed her training, confidence, and outlook heading into the HYROX World Championships.Finally, we talk about racing doubles and relays at Worlds, balancing strength with endurance, social media, sponsorships, and her goals for the future.House Of The Dragon Season 3 Episode 3Rhaenyra's difficult first days as queen.Daemon's confrontation with Ormund Hightower.The reveal of Daeron Targaryen and his dragon.Why everyone seems willing to challenge Rhaenyra.Corlys confronts Rhaenyra over legitimizing his sons.The growing role of Alicent as Rhaenyra's advisor.The rat crisis, the smallfolk, and ruling the realm.Ulf, Hugh Hammer, and the newest dragonriders.The Tumbleton campaign and what comes next.Winners, losers, and predictions after Episode 3.Today's episode is sponsored by Wodify. When your HYROX gym needs to run smoothly, Wodify delivers. From scheduling and programming to performance tracking and milestone celebrations, all the tools you need are built right in.Book a demo here.Today's episode is sponsored by Metl. MetL™ stands for honesty and health. Every ingredient is listed clearly, no fillers, no hidden sugars, no gimmicks. It's more than a beverage; it's a movement redefining what it means to stay energized, for kids, parents, and future generations. Learn more at metldrink.comAlso by Stryd – Personalized Run Training. Powered by the Best Data. Experience the future of running with our most advanced power meter yet, combined with Adaptive Training.Listen on Apple or SpotifySupport us through The Cup Of CoffeeFollow Hybrid Fitness Media on IG
Laurence & Spiegs discuss what the White Sox should do to help Noah Schulz with his control
Wahlkampf mit Fußfessel? Nach dem Urteil des Berufungsgerichts ist klar: Marine Le Pen könnte bei der Präsidentschaftswahl in Frankreich antreten, allerdings sind die Hürden hoch. Und: Der Fall Balogun schadet der FIFA und dem Fußball. Schulz, Sandra
What if one of the most powerful medicines for longevity, resilience, happiness, cognitive health, and disease prevention wasn't found in a supplement, a prescription, or a cutting-edge biohack—but in the people around you? In this powerful solo episode, Darin Olien dives into one of the most overlooked health crises of our time: loneliness. Drawing from the landmark 85-year Harvard Adult Development Study, the U.S. Surgeon General's loneliness epidemic report, Blue Zones research, neuroscience, and evolutionary biology, Darin reveals why meaningful human connection may be one of the strongest predictors of health and longevity ever discovered. From oxytocin, cortisol, inflammation, vagal tone, and nervous system regulation to suburban design, social media, and the collapse of community structures, Darin exposes the hidden biological costs of isolation—and offers a practical roadmap for rebuilding the human connections we were biologically designed to need. What You'll Learn The stunning findings from Harvard's 85-year Adult Development Study Why relationships outperform wealth, genetics, diet, and exercise as predictors of well-being How loneliness increases the risk of premature death, dementia, heart disease, and stroke Why social isolation creates measurable biological stress responses The role of oxytocin in lowering inflammation and regulating stress How human connection affects the autonomic nervous system Why Blue Zone communities consistently prioritize social connection The biological difference between digital interaction and real human presence How modern architecture and technology contribute to loneliness Why community is a biological necessity—not a luxury Practical ways to rebuild meaningful relationships today How connection may be one of the most powerful health interventions available Chapters 00:00:00 – Welcome to SuperLife 00:00:33 – Sponsor: Bite Toothpaste and reducing plastic waste 00:02:49 – The most powerful health study ever conducted 00:03:01 – Harvard follows 724 people for 85 years 00:03:40 – The surprising predictor of a long, healthy life 00:04:00 – Why relationships beat wealth, genetics, diet, and exercise 00:04:42 – The Surgeon General's loneliness epidemic warning 00:05:19 – Introducing the medicine you're not taking 00:05:53 – The health benefits of genuine community 00:06:21 – The fatal convenience of modern life 00:06:47 – Replacing human connection with digital connection 00:07:12 – Why modern convenience may be creating isolation 00:07:23 – Social isolation and premature mortality 00:08:02 – Loneliness and the equivalent of smoking 15 cigarettes a day 00:08:43 – Increased risks of heart disease, stroke, and dementia 00:09:10 – Why loneliness is a biological threat 00:09:52 – The science behind social isolation 00:10:11 – Sponsor: Manna Vitality 00:12:06 – Humans as the most socially dependent species 00:12:53 – Why connection regulates the nervous system 00:13:29 – The autonomic nervous system and social safety 00:13:56 – The brain's constant question: Am I safe? 00:14:03 – The biology of belonging 00:14:24 – The ventral vagal state explained 00:14:55 – Why connection creates measurable physiological changes 00:15:03 – What happens when isolation becomes chronic 00:15:52 – Oxytocin: far more than the "love hormone" 00:16:20 – Eye contact, touch, meals, and human bonding 00:16:42 – How oxytocin lowers stress and inflammation 00:17:04 – Why no supplement can replace connection 00:17:17 – The pharmacology of authentic human moments 00:18:06 – Free medicine hidden in plain sight 00:18:39 – Dan Buettner and the Blue Zones 00:19:29 – What the world's longest-lived populations have in common 00:19:36 – Okinawa's lifelong friendship circles 00:20:08 – Sardinia's active elders and social roles 00:20:40 – Greece's culture of connection and communal meals 00:21:03 – Why longevity wasn't hacked—it was lived 00:21:38 – Social connection as the foundation of daily life 00:22:01 – The shocking decline in face-to-face interaction 00:22:21 – Young people losing 70% of in-person social time 00:22:58 – How community was systematically dismantled 00:23:00 – Robert Putnam's Bowling Alone 00:23:49 – Doing life together versus doing life alone 00:24:05 – How suburban design creates isolation 00:24:49 – The built environment shapes human behavior 00:24:55 – Social media and the promise of connection 00:25:20 – Why digital connection fails biologically 00:25:33 – Social comparison, anxiety, and nervous system stress 00:25:49 – More connected online, more isolated in reality 00:26:03 – A call to action: treating relationships like health practices 00:27:00 – Practical ways to rebuild community 00:28:00 – Prioritizing people over convenience 00:29:00 – Deep conversations, presence, and intentional connection 00:30:00 – Reclaiming community in modern life 00:31:00 – Final thoughts on connection, belonging, and health 00:31:53 – Closing remarks and outro Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "The longest-running study in human history reached a conclusion that should fundamentally change how we think about health: the quality of our relationships predicts our happiness, resilience, and longevity more than almost anything else. Human connection isn't a luxury, a personality trait, or a nice bonus when life slows down. It is biology. It is medicine. And in a world increasingly designed for isolation, rebuilding community may be one of the most important health decisions we ever make." Bibliography/Sources: Primary Research — Loneliness, Social Isolation & Health Associated Press. (2023, May 2). Surgeon general: Loneliness poses health risks as deadly as smoking. PBS NewsHour. https://www.pbs.org/newshour/health/surgeon-general-loneliness-poses-health-risks-as-deadly-as-smoking Cacioppo, J. T., & Hawkley, L. C. (2009). Perceived social isolation and cognition. Trends in Cognitive Sciences, 13(10), 447–454. https://doi.org/10.1016/j.tics.2009.06.005 Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010). Social relationships and mortality risk: A meta-analytic review. PLoS Medicine, 7(7), e1000316. https://doi.org/10.1371/journal.pmed.1000316 Office of the Surgeon General. (2023). Our epidemic of loneliness and isolation: The U.S. Surgeon General's advisory on the healing effects of social connection and community. U.S. Department of Health and Human Services. https://www.hhs.gov/sites/default/files/surgeon-general-social-connection-advisory.pdf Waldinger, R. J., & Schulz, M. S. (2010). What's love got to do with it? Social functioning, perceived health, and daily happiness in married octogenarians. Psychology and Aging, 25(2), 422–431. https://doi.org/10.1037/a0019087 Neuroscience — Oxytocin, Polyvagal Theory & Community Biology Carter, C. S. (1998). Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology, 23(8), 779–818. https://doi.org/10.1016/S0306-4530(98)00055-9 Eisenberger, N. I., & Lieberman, M. D. (2004). Why rejection hurts: A common neural alarm system for physical and social pain. Trends in Cognitive Sciences, 8(7), 294–300. https://doi.org/10.1016/j.tics.2004.05.010 Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological Psychiatry, 54(12), 1389–1398. https://doi.org/10.1016/S0006-3223(03)00465-7 Porges, S. W. (2011). The polyvagal theory: Neurophysiological foundations of emotions, attachment, communication, and self-regulation. W. W. Norton & Company. https://wwnorton.com/books/9780393707007 Blue Zones Research Buettner, D., & Skemp, S. (2016). Blue Zones: Lessons from the world's longest lived. American Journal of Lifestyle Medicine, 10(5), 318–321. https://doi.org/10.1177/1559827616637066 Kreouzi, M., Theodorakis, N., & Constantinou, C. (2022). Lessons learned from Blue Zones, lifestyle medicine pillars and beyond. American Journal of Lifestyle Medicine. https://doi.org/10.1177/15598276221118494 Suzuki, M., Willcox, B. J., & Willcox, D. C. (2001). Implications from and for food cultures for cardiovascular disease: Longevity. Asia Pacific Journal of Clinical Nutrition, 10(2), 165–171. https://doi.org/10.1111/j.1440-6047.2001.00219.x The power of environment: A comprehensive review of the exposome's role in healthy aging. (2025). PubMed Central (PMC11858149). https://pmc.ncbi.nlm.nih.gov/articles/PMC11858149/ Social Capital & Community Decline Oldenburg, R. (1999). The great good place: Cafés, coffee shops, bookstores, bars, hair salons, and other hangouts at the heart of a community. Marlowe & Company. https://books.google.com/books?id=cK80BwAAQBAJ Putnam, R. D. (2000). Bowling alone: The collapse and revival of American community. Simon & Schuster. https://www.simonandschuster.com/books/Bowling-Alone/Robert-D-Putnam/9780743203043 Sbarra, D. A., Briskin, J. L., & Slatcher, R. B. (2019). Smartphones and close relationships: The case for an evolutionary mismatch. Perspectives on Psychological Science, 14(4), 596–618. https://doi.org/10.1177/1745691619826535 Twenge, J. M., Joiner, T. E., Rogers, M. L., & Martin, G. J. (2018). Increases in depressive symptoms, suicide-related outcomes, and suicide rates among U.S. adolescents after 2010 and links to increased new media screen time. Journal of Adolescent Health, 62(1), 78–85. https://doi.org/10.1016/j.jadohealth.2017.06.014 U.S. Bureau of Labor Statistics. (2020). American time use survey. U.S. Department of Labor. https://www.bls.gov/tus/ Pennebaker & Authentic Disclosure Brown, B. (2012). Daring greatly: How the courage to be vulnerable transforms the way we live, love, parent, and lead. Gotham Books. https://brenebrown.com/book/daring-greatly/ Pennebaker, J. W. (1997). Writing about emotional experiences as a therapeutic process. Psychological Science, 8(3), 162–166. https://doi.org/10.1111/j.1467-9280.1997.tb00403.x