POPULARITY
6 episodes with sulfasalazine
6 episodes with sulfasalazine
4 episodes with sulfasalazine
In this episode, we review the high-yield topic of Sulfasalazine from the Gastrointestinal section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Sulfasalazine from the Gastrointestinal section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message
Follow Chelsey on Instagram @chelseyboom.Check out the website, myimmunesystempod.com, where you can get in contact with Chelsey, listen to old episodes, learn about the RA Warrior Group, buy some My Immune System Hates Me merchandise, and apply to be a guest on the show.Don't forget to rate and review the show, and follow us on Instagram and Facebook @myimmunesystempod***Any information discussed in this podcast is strictly my opinion and those of my guests and are for informational purposes only. We are speaking from our personal experiences and you should always consult with your doctor or medical team.
In the last 4 years, Yvonne has dropped Sulfasalazine and greatly reduced inflammation across the body with the Paddison Program. For the transcription and for more helpful information visit http://www.rheumatoidsolutions.com Paddison Program for Rheumatoid Arthritis http://www.paddisonprogram.com/rheumatoid-arthritis Rheumatoid Support - http://www.rheumatoidsupport.com
Give Jenni a follow @gracefully.jen on Instagram.Check out our website, myimmunesystempod.com, where you can get in contact with Chelsey, listen to old episodes, learn about the RA Warrior Group, buy a signed copy of Chelsey's upcoming book, and apply to be a guest on the show.Don't forget to rate and review the show, and follow us on Instagram and Facebook @myimmunesystempodThis episode is sponsored by Grace & Able. Visit https://www.graceandable.com/discount/IMMUNE10 for 10% off your purchase. Follow Grace & Able on Facebook and Instagram.***Any information discussed in this podcast is strictly my opinion and those of my guests and are for informational purposes only. We are speaking from our personal experiences and you should always consult with your doctor or medical team.
Make sure you rate and subscribe to My Immune System Hates Me! and follow @myimmunesystempod on Instagram and Facebook for episode updates. You can also email myimmunesystempod@gmail.com if you'd like to get in touch!You can find Chelsey on Instagram @chelseyboom. Her Rheumatoid Arthritis Warrior Group will meet on Thursdays at 7pm EDT. To join the conversation, join the Facebook group or just hop on Zoom! Rheumatoid Arthritis Warrior Group Zoom LinkCheck out Samantha's graphic design page on Instagram @spasielskidesignsMisti's websites are Misti Blu Dream,Wildling Apothecary, and Blu Dream Health Collective. Her Instagram pages are @mistibluday,@wildlingapothecaryus, and @bludreamhealthYou can visit Jana's website janamilligan.com and check out her shop at millieandmoonflower.com. If you want to get in touch with her, you can find her on Instagram @janamilligan, on Facebook at Autoimmune Coaching for Women, or you can email her directly at info@janamilligan.com.If you'd like to get in touch with Anna, you can find her on Facebook, Instagram, or on YouTube.You can find Mary on Instagram, Facebook, or Twitter, as well as her website, MaryBergstrom.com.Don't forget to check out Gillian's website and Instagram! You should also listen to her podcast, Sober Powered.Make sure you check out Brandon's website, Instagram, Twitter, and Facebook. Preorder Brandon's book, "I'm Still Kickin'" here!You can find Stefanie through her website, Instagram, and Facebook pages.Follow Ray on Instagram @switchdad.
Don't forget to check out Stefanie's website, Instagram, and Facebook pages!Make sure you rate and subscribe to My Immune System Hates Me! and follow @myimmunesystempod on Instagram and Facebook for episode updates. You can also email myimmunesystempod@gmail.com if you'd like to get in touch!***Any information discussed in this podcast is strictly my opinion and those of my guests and are for informational purposes only. We are speaking from our personal experiences and you should always consult with your doctor or medical team.
You can follow Chelsey on Instagram @chelseyboom.Make sure you rate and subscribe to My Immune System Hates Me! and follow @myimmunesystempod on Instagram and Facebook for episode updates. You can also email myimmunesystempod@gmail.com if you'd like to get in touch!***Any information discussed in this podcast is strictly my opinion and those of my guests and are for informational purposes only. We are speaking from our personal experiences and you should always consult with your doctor or medical team.
When Linda Wondrack was diagnosed with rheumatoid disease in 2015, she never imagined that her treatment with Sulfasalazine would end up leaving her even more severely ill. In the wake of a complicated recovery from DRESS, she shares the physical and psychological toll this delayed drug reaction can take... and the importance of self-advocacy and self-care. Linda's Website: Surviving DRESShttps://www.survivingdress.org
Michael Symon's Book "Fix It with Food" - http://www.michaelsymon.com/cookbooks-1LightForce Therapy Laser - https://www.lightforcemedical.comMake sure you rate and subscribe to My Immune System Hates Me! and follow @myimmunesystempod on Instagram for episode updates. You can also email myimmunesystempod@gmail.com if you'd like to get in touch!***Any information discussed in this podcast is strictly my opinion and those of my guests and are for informational purposes only. We are speaking from our personal experiences and you should always consult with your doctor or medical team.
The Simple Nursing Podcast - The Simplest Way To Pass Nursing School
Gastrointestinal meds. Sulfasalazine. Free quiz & full course at https://Simplenursing.com/nursing-school Pharmacology Master Class - 100 videos not on YouTube - Try it for Free! Pharmacology Master Class - Try it for Free: https://Simplenursing.com/nursing-school 100 videos not on YouTube FREE Access to new app + 1,000 videos not on youtube! https://Simplenursing.com/nursing-school NCLEX FREE TRIAL: https://simplenursing.com/NCLEX STAY IN TOUCH
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Sulfasalazine is a medication that can be used for diseases like rheumatoid arthritis, Crohn's disease, and Ulcerative Colitis. Because sulfasalazine can cause GI upset, this is a major reason why we try to break up the dose and give it multiple (at least two) times per day. LFT and CBC monitoring are recommended with sulfasalazine due to its low potential to cause liver dysfunction, aplastic anemia, and agranulocytosis. Sulfasalazine can impair folic acid absorption and lead to potential deficiency. A patient deficient in folic acid is at higher risk for developing anemia.
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I’m looking forward to sharing with you some of our community’s questions that have come in over the past few weeks… Let’s get started! Gretchen: Hi Dr Cabral, Can you tell me if the ionic foot bath helps to detox? I hear controversy whether it is actually removing toxins or not. Thank you! Anonymous: Hi Dr. Cabral, I’m a massage therapist and I believe that I’ve picked up a skin fungus from one of my clients via contact dermatitis. I have eczema on my hands and when it flares up, I can go into scratch mode w/o thinking about it. Because of this, I probably had small open sores on my hands that I couldn’t see which, I’m sure, contributed to making me susceptible to any skin pathologies. What do you suggest as a cure for skin fungus? I’ve been using OTC creams like Lamisil and Lotrimin for coming up on a month now and while the bumps, oozing and itchiness have subsided a great deal, there are still a few stubborn spots. I’ve also started drinking sarsaparilla in the form of a tea to also target the fungus internally since I read that sarsaparilla is a detoxifier. Any help you can give would be greatly appreciated! Thanks very much! Casey: Hi Stephen, massive fan of your podcast I tell everyone about them here in Australia. Could you do a podcast on placenta encapsulation or eating your placenta & your thoughts on it. Iv heard very mixed reviews. Kathleen: Hello, I’ve recently heard about you from listening to the Melissa Ambrosini podcast. Since having my child 18months ago I’ve suffered chronic inflammation, pain in my joints, depression, low mood, etc. My inflammation markers were so high that my gp arranged for me to go to hospital for an appointment with a Rhuematologist. After various blood tests for arthritis, lupus, etc they all came back negative. The rheumatologist couldn’t tell me what was causing the inflammation but prescribed me the following; Naproxen, Plaquenil, Sulfasalazine & now recently Methoblastin. They told me I need to take these to reduce the inflammation so my joints don’t go deformed. All of these meds are immunosuppressants. Having a small child who attends day care I am constantly sick & rundown. Two weeks ago I had to have two iron infusions (ferrinject) as I had anemia. I would love to stop taking these medications and heal by body naturally. I’m in Australia, & I’m unsure which test I need? If you can please recommend the right one for me that would be wonderful. Thank you for your time. Regards Kathleen. Ps. I’m 35, 4-5 years ago I was competing in triathlons, now I can’t even run. Eliana: Hi, I would love to hear what you think of tanning beds! I’ve heard most doctors say it leads to skin cancer and others say it’s actually beneficial once a week for a short length of time. Also, are berries better to have after a workout because of antioxidants cleaning up free radicals, or are the benefits just as good if eaten before the workout? Mary: Hi, I would like to find out more about the upcoming program to become a "coach" or "integrative practitioner," unsure if I'm identifying it correctly. Can you please direct me as to where to learn more? Currently, I am an RN, Certified Diabetic Educator and Credentialed School Nurse. I also have my own personal journey towards wellness and would love to learn more. thank you!! Maureen: Hi there, I am a listener of the podcast and I am eager to hopefully work with you in the future and have been doing a lot of research. I have a ton of health issues that have been going on for a little over two years and still haven't solved anything. However, I live in NYC - and I keep seeing the messages that lab sales are prohibited to those that live in NY state. My question is - why is this and is there anything I can do about it? I can't accept that because I live in NY I won't be able to get the tests I need to heal myself - is there any way I can work around this or figure this out? Have you worked with anyone from NY before? Thank you in advance! Maureen Valerie: Hi goodmorning, so I'm 21 and have been trying to lose body fat (not weight) for a bit over 3 years now. Iv done trial and error both in food and exercise. I got my RMR studied at a local university using the oxygen mask and have been eating at that deficit for months now. I weigh my food on a digital food scale and log it into the calorie counting app and pay attention to my macros. I eat healthy and I havnt seen any progress instead iv seen weight gain which has been through higher fat. I got my blood work done it came back normal my GP said I should do more exams such as hair tissue exams and such but 1) idk where to take it and 2) ur packets are expensive for me to get so I need ur help through advice please iv gone around and asked everyone Antony: Hi Dr. Cabral! Question about Accutane (Isotretinoin) Thank you so much for your message at the end chapters of Rainbarrel effect. It's made a profound difference in my life. What are your thoughts on detoxifying Accutane? I took it 5 years ago when I was 18, on a high 80mg dose everyday from an unaware dermatologist. It has wrecked my eyes and caused burning dry eyes with severe meibomian gland dysfunction and gland atrophy. I am able to cope by taking high dose Omega 3's thanks to a PubMed study I found myself. I'm not sure if the glands will regenerate (conventional opthamologists says no) but I have other health issues as well after taking Accutane. Accutane also caused me my first depressive episode and panic attack. I've since had generalized anxiety since then, fatigue, and brain fog, which I still experience to this day. Besides working on the liver with coffee enemas, broccoli sprouts, and beet juices, do you have any targeted detoxifying modality for fat soluble pharmaceuticals like Accutane (Assuming it is stored)? I've taken it for 5 months in the past at incredible high doses. I've heard of the niacin sauna potentially eliminating any 'stored' fat-soluble Accutane. What are your thoughts Dr. Cabral? Please keep doing what you do :) Thank you for tuning into this weekend’s Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Specific Show Notes & Resources: http://StephenCabral.com/1038 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - - Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements - - - Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - - > View all Functional Medicine lab tests (View all Functional Medicine lab tests you can do right at home for you and your family!)
We discuss how: - After being diagnosed Lupus Penina was on medication and feeling extreme pain - She was put on Sulfasalazine and after a few months started having itchy skin as a side effect - Looking at the other side effects she would have encountered down the road, she decided to try different approaches - While searching information through the internet she found Clint's TED Talk and found great inspiration in it - After a couple of hesitations she drastically changed her diet to the Paddison Program for Rheumatoid Arthritis and her pain was immediately reduced - Her physician supported her in the process, because other patients did the same before with success - She's now off Sulfasalazine and pain-free
Lindy was sick a lot as a kid with chronic allergies and infections which lead to her taking a lot of antibiotics. She was a chronic worrier. Symptoms started in her gastrointestinal tract and then went into her back. She spent years searching for answers and eventually was diagnosed with AS. She was on Nsaids, Sulfasalazine, Methotrexate, Humira and Prednisone. She eventually had a Gut Microbial Transplant which lead to 80-90% improvement. Lindy lives in Georgia and is 42 years old. She graduated from the University of Georgia with a degree in English Literature and a Master's in Instructional Technology. She’s been a school librarian for 15 years, and in the evenings/weekends, a trapeze artist. It was a sincere pleasure to create this episode with her.
We discuss how: - Johanna has been experiencing swellings and pain for 4 years - She's been on Methotrexate, Sulfasalazine ,Prednisone and also Apremilast for about two years with tremendous side effects - Within 2 years all other options failed and she started Enbrel, but it didn't bring any stable improvement - In November 2017, just when she hit her all-time low, she found the Paddison Program - Within 3 1/2 months her energy is back and she's pain-free and drug-free - Here hair is grown back, after she lost about 40 percent of it due to Methotrexate - Bikram Yoga has also turned out to be a great energy source - She found great inspiration and support in the Program's material and community
We discuss how: - Shelly is celebrating 1 year off drugs and 1 month off medications thanks to the Paddison Program - She found great support in the Paddison Program community - Her liver levels were very high during therapy with Methotrexate, Sulfasalazine and hydroxychloroquine - She went on another therapy with Prednisone and Methotrexate that caused hair loss and fatigue - Within two weeks after starting the Program she was able to completely cut off Prednisone - Her blood tests are now on track - She now exercises has more control on her breath - She enjoys her health in a variety of ways
We discuss how: - Trinette has come off all her medications in the last 18 months, and is now pain-free and drug-free with the Paddison Program - She started taking Prednisone for eight months in 2005 and then Methotrexate, Plaquenil and Sulfasalazine for almost 10 years - Juice fast was a total reset of her body and changed her taste buds - She and her family are now enjoying a plant-based diet - Her C-reactive protein is now 1 - The prolonged use of Methotrexate caused her two skin cancers - She's now drug-free and her skin and hair have greatly improved - She can hold things and go for a walk again, after years of pain due to RA - Her mother has Graves disease and is now on the Paddison Program with great benefit - Her mother-in-law is in her third round of breast cancer and is now on the Program as well - She's lost 10 kilos following the Paddison Program
In this episode with Lor you'll learn: - The dangers of long term antibiotic use - How early bad eating habits triggered psoriasis - The shocking side effects prednisone can cause - How reactions to NSAID's like Naproxen can occur - Challenges of Plaquenil, Sulfasalazine and Methotrexate - How Cimzia had to be stopped due to it's side effects NOW: No more psoriasis, RA a fraction of it's previous self, drug free
A review of Osteoarthritis for the the Pain Practitioner. To hear about Ankylosing spondylitis please subscribe to our premium episodes Discussed: Joint Replacement DMARDs NSAIDs Syndesmophytes Crepitus Xray findings Bouchards PainExam Podcast Download our iphone App! Download our Android App! For more information on Pain Management Topics and keywords Go to PainExam.com David Rosenblum, MD specializes in Pain Management and is the Director of Pain Management at Maimonides Medical Center and AABP Pain Managment For evaluation and treatment of a Painful Disorder, go to www.AABPPain.com 718 436 7246 DISCLAIMER: Doctor Rosenblum IS HERE SOLELY TO EDUCATE, AND YOU ARE SOLELY RESPONSIBLE FOR ALL YOUR DECISIONS AND ACTIONS IN RESPONSE TO ANY INFORMATION CONTAINED HEREIN. This podcasts is not intended as a substitute for the medical advice of physician to a particular patient or specific ailment. You should regularly consult a physician in matters relating to yours or another's health. You understand that this podcast is not intended as a substitute for consultation with a licensed medical professional. Copyright © 2015 QBazaar.com, LLC All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, recording or otherwise, without the prior written permission of the author. References https://en.wikipedia.org/wiki/Ankylosing_spondylitis https://en.wikipedia.org/wiki/Osteoarthritis "Ankylosing Spondylitis -Professional reference for Doctors - Patient UK". Patient UK. Retrieved 26 May 2014. Jump up ^ Jiménez-Balderas FJ, Mintz G (1993). "Ankylosing spondylitis: clinical course in women and men". J Rheumatol 20 (12): 2069–72. PMID 7516975. Jump up ^ Longo, Dan Louis; Fauci, Anthony S.; Harrison, Tinsley Randolph; Kasper, Dennis L.; Hauser, Stephen L.; Jameson, J. Larry; Loscalzo, Joseph (2012). Harrison's Principles of Internal Medicine. Vol. 1 (18th ed.). McGraw-Hill. ISBN 978-0-07-163244-7. Jump up ^ "Ankolysing Spondylitis". Arthritis Action. Retrieved 12 August 2015. Jump up ^ Thomas E, Silman AJ, Papageorgiou AC, Macfarlane GJ, Croft PR (1998). "Association between measures of spinal mobility and low back pain. An analysis of new attenders in primary care". Spine 23 (2): 343–7. doi:10.1097/00007632-199802010-00011. PMID 9507623. Jump up ^ Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994). "A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index". J Rheumatol 21 (12): 2286–91. PMID 7699630. Jump up ^ Calin A, Garrett S, Whitelock H, Kennedy LG, O'Hea J, Mallorie P, Jenkinson T (1994). "A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index". J Rheumatol 21 (12): 2281–5. PMID 7699629. Jump up ^ Toivanen A, Möttönen T (1998). "Ankylosing spondylitis: current approaches to treatment". BioDrugs 10 (3): 193–200. doi:10.2165/00063030-199810030-00003. PMID 18020595. Jump up ^ Williams RO, Paleolog E, Feldmann M (2007). "Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases". Curr Opin Pharmacol 7 (4): 412–7. doi:10.1016/j.coph.2007.06.001. PMID 17627887. Jump up ^ Kroon F, Landewé R, Dougados M, van der Heijde D (October 2012). "Continuous NSAID use reverts the effects of inflammation on radiographic progression in patients with ankylosing spondylitis". Ann. Rheum. Dis. 71 (10): 1623–9. doi:10.1136/annrheumdis-2012-201370. PMID 22532639. Jump up ^ Chen J, Lin S, Liu C (27 November 2014). "Sulfasalazine for ankylosing spondylitis.". The Cochrane database of systematic reviews 11: CD004800. doi:10.1002/14651858.CD004800.pub3. PMID 25427435. Jump up ^ Chen J, Veras MM, Liu C, Lin J (28 February 2013). "Methotrexate for ankylosing spondylitis.". The Cochrane database of systematic reviews 2: CD004524. doi:10.1002/14651858.CD004524.pub4. PMID 23450553. Jump up ^ Braun J, van den Berg R, Baraliakos X, Boehm H, Burgos-Vargas R, Collantes-Estevez E, Dagfinrud H, Dijkmans B, Dougados M, Emery P, Geher P, Hammoudeh M, Inman RD, Jongkees M, Khan MA, Kiltz U, Kvien T, Leirisalo-Repo M, Maksymowych WP, Olivieri I, Pavelka K, Sieper J, Stanislawska-Biernat E, Wendling D, Ozgocmen S, van Drogen C, van Royen B, van der Heijde D (June 2011). "2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis". Ann. Rheum. Dis. 70 (6): 896–904. doi:10.1136/ard.2011.151027. PMC 3086052. PMID 21540199. Jump up ^ Braun J, Sieper J (2007). "Ankylosing spondylitis". Lancet 369 (9570): 1379–90. doi:10.1016/S0140-6736(07)60635-7. PMID 17448825. Jump up ^ Brulhart L, Nissen MJ, Chevallier P, Gabay C (February 2010). "Mixed response to tocilizumab for ankylosing spondylitis". Annals of the Rheumatic Diseases 69 (12): 2217–2218. doi:10.1136/ard.2009.126706. PMID 20851032. Jump up ^ Rodríguez-Escalera C, Fernández-Nebro A (2008). "The use of rituximab to treat a patient with ankylosing spondylitis and hepatitis B". Rheumatology47 (11): 1732–1733. doi:10.1093/rheumatology/ken362. PMID 18786966. Jump up ^ "Philadelphia Panel evidence-based clinical practice guidelines on selected rehabilitation interventions: overview and methodology". Phys Ther 81 (10): 1629–40. 2001. PMID 11589641. Jump up ^ Dagfinrud H, Kvien TK, Hagen KB (23 January 2008). "Physiotherapy interventions for ankylosing spondylitis.". The Cochrane database of systematic reviews (1): CD002822. doi:10.1002/14651858.CD002822.pub3. PMID 18254008. Jump up ^ Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A (2002). "Ankylosing spondylitis: an overview". Ann. Rheum. Dis. 61 Suppl 3: iii8–18. doi:10.1136/ard.61.suppl_3.iii8. PMC 1766729. PMID 12381506. Jump up ^ Bond D (2013). "Ankylosing spondylitis: diagnosis and management". Nurs Stand 28 (16-18): 52–9; quiz 60. doi:10.7748/ns2013.12.28.16.52.e7807. PMID 24345154. ^ Jump up to: a b Alpert, Joseph S. (2006). The AHA Clinical Cardiac Consult. Lippincott Williams & Wilkins. ISBN 0-7817-6490-4. Jump up ^ Ahn NU, Ahn UM, Nallamshetty L, Springer BD, Buchowski JM, Funches L, Garrett ES, Kostuik JP, Kebaish KM, Sponseller PD (2001). "Cauda Equina Syndrome in AS (The CES-AS Syndrome): Meta-analysis of outcomes after medical and surgical treatments". J of Spinal Disorders 14 (5): 427–433. doi:10.1097/00002517-200110000-00009. PMID 11586143. ^ Jump up to: a b Bakland G, Gran JT, Nossent JC (November 2011). "Increased mortality in ankylosing spondylitis is related to disease activity". Ann. Rheum. Dis.70 (11): 1921–5. doi:10.1136/ard.2011.151191. PMID 21784726. Jump up ^ Radford EP, Doll R, Smith PG (September 1977). "Mortality among patients with ankylosing spondylitis not given X-ray therapy". N. Engl. J. Med. 297(11): 572–6. doi:10.1056/NEJM197709152971103. PMID 887115. Jump up ^ Del Din S, Carraro E, Sawacha Z, Guiotto A, Bonaldo L, Masiero S, Cobelli C (2011). "Impaired gait in ankylosing spondylitis". Med Biol Eng Comput 49(7): 801–9. doi:10.1007/s11517-010-0731-x. PMID 21229328 "Ankylosing Spondylitis -Professional reference for Doctors - Patient UK". Patient UK. Retrieved 26 May 2014. 2.Jump up ^ Jiménez-Balderas FJ, Mintz G (1993). "Ankylosing spondylitis: clinical course in women and men". J Rheumatol 20 (12): 2069–72. PMID 7516975. 3.Jump up ^ Longo, Dan Louis; Fauci, Anthony S.; Harrison, Tinsley Randolph; Kasper, Dennis L.; Hauser, Stephen L.; Jameson, J. Larry; Loscalzo, Joseph (2012). Harrison's Principles of Internal Medicine. Vol. 1 (18th ed.). McGraw-Hill. ISBN 978-0-07-163244-7. 4.Jump up ^ "Ankolysing Spondylitis". Arthritis Action. Retrieved 12 August 2015. 5.Jump up ^ Thomas E, Silman AJ, Papageorgiou AC, Macfarlane GJ, Croft PR (1998). "Association between measures of spinal mobility and low back pain. An analysis of new attenders in primary care". Spine 23 (2): 343–7. doi:10.1097/00007632-199802010-00011. PMID 9507623. 6.Jump up ^ Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994). "A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index". J Rheumatol 21 (12): 2286–91. PMID 7699630. 7.Jump up ^ Calin A, Garrett S, Whitelock H, Kennedy LG, O'Hea J, Mallorie P, Jenkinson T (1994). "A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index". J Rheumatol 21 (12): 2281–5. PMID 7699629. 8.Jump up ^ Toivanen A, Möttönen T (1998). "Ankylosing spondylitis: current approaches to treatment". BioDrugs 10 (3): 193–200. doi:10.2165/00063030-199810030-00003. PMID 18020595. 9.Jump up ^ Williams RO, Paleolog E, Feldmann M (2007). "Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases". Curr Opin Pharmacol 7 (4): 412–7. doi:10.1016/j.coph.2007.06.001. PMID 17627887. 10.Jump up ^ Kroon F, Landewé R, Dougados M, van der Heijde D (October 2012). "Continuous NSAID use reverts the effects of inflammation on radiographic progression in patients with ankylosing spondylitis". Ann. Rheum. Dis. 71 (10): 1623–9. doi:10.1136/annrheumdis-2012-201370. PMID 22532639. 11.Jump up ^ Chen J, Lin S, Liu C (27 November 2014). "Sulfasalazine for ankylosing spondylitis.". The Cochrane database of systematic reviews 11: CD004800. doi:10.1002/14651858.CD004800.pub3. PMID 25427435. 12.Jump up ^ Chen J, Veras MM, Liu C, Lin J (28 February 2013). "Methotrexate for ankylosing spondylitis.". The Cochrane database of systematic reviews 2: CD004524. doi:10.1002/14651858.CD004524.pub4. 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Rheumatoid arthritis - a long term condition - for iPad/Mac/PC
Transcript -- Liz talks about the various medications she has had since her condition was first diagnosed and how she is now in drug-controlled remission.
Rheumatoid arthritis - a long term condition - for iPad/Mac/PC
Transcript -- Liz, who was diagnosed with RA in 1996, talks about living with this long term condition.
Rheumatoid arthritis - a long term condition - for iPad/Mac/PC
Liz, who was diagnosed with RA in 1996, talks about living with this long term condition.
Rheumatoid arthritis - a long term condition - for iPod/iPhone
Transcript -- Liz talks about the various medications she has had since her condition was first diagnosed and how she is now in drug-controlled remission.
Liz talks about the various medications she has had since her condition was first diagnosed and how she is now in drug-controlled remission.
Rheumatoid arthritis - a long term condition - for iPod/iPhone
Liz, who was diagnosed with RA in 1996, talks about living with this long term condition.
Rheumatoid arthritis - a long term condition - for iPod/iPhone
Transcript -- Liz, who was diagnosed with RA in 1996, talks about living with this long term condition.
Liz talks about the various medications she has had since her condition was first diagnosed and how she is now in drug-controlled remission.
Background: Bile acid-induced apoptosis in hepatocytes can be antagonized by NF-κBdependent survival pathways. Sulfasalazine modulates NF-κB in different cell types. We aimed to determine the effects of sulfasalazine and its metabolites sulfapyridine and 5-aminosalicylic acid (5-ASA) on bile acid-induced apoptosis in hepatocytes. Methods: Apoptosis was determined by caspase assays and immunoblotting, NF-κB activation by EMSA and reporter gene assays, generation of reactive oxygen species (ROS) fluorometrically, bile secretion gravimetrically and bile acid uptake radiochemically and by gaschromatography in HepG2-Ntcp cells and isolated perfused rat livers. Results: Glycochenodeoxycholic acid (GCDCA, 75μmol/L)-induced apoptosis was reduced by sulfasalazine dose-dependently (1-1000 μmol/L) in HepG2-Ntcp cells, whereas its metabolites 5- ASA and sulfapyridine had no effect. Sulfasalazine significantly reduced GCDCA-induced activation of caspases 9 and 3. In addition, sulfasalazine activated NF-κB, and decreased GCDCA-induced generation of ROS. Bile acid uptake was competetively inhibited by sulfasalazine. In perfused rat livers, GCDCA (25 μmol/L)-induced liver injury and extensive hepatocyte apoptosis were significantly reduced by simultaneous administration of 100 μmol/L sulfasalazine: LDH and GPT activities were reduced by 82% and 87%, respectively, and apoptotic hepatocytes were observed only occasionally. GCDCA uptake was reduced by 45±5% when sulfasalazine was coadministered. However, when 50% of GCDCA (12.5 μmol/L) were administered alone, marked hepatocyte apoptosis and liver injury were again observed questioning the impact of reduced GCDCA uptake for the antiapoptotic effect of sulfasalazine. Conclusion: Sulfasalazine is a potent inhibitor of GCDCA-induced hepatocyte apoptosis in vitro and in the intact liver.
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