Podcasts about duchenne muscular dystrophy dmd

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma e Biotech world. Sage has rejected Biogen's unsolicited buyout offer and will seek strategic alternatives. Biogen and Eisai have received approval for a monthly maintenance regimen for Alzheimer's drug Leqembi. Veru's drug has shown promise in sparing lean mass in overweight adults on Wegovy. The Duchenne muscular dystrophy space is on the verge of a pivotal era with several companies developing investigational therapies. Akero has rebounded in a mid-stage trial, Daiichi Sankyo is optimistic for 2025, and Allakos is cutting its workforce. The text discusses the advancements in the Duchenne Muscular Dystrophy (DMD) space as it enters a pivotal era, with companies such as Capricor Therapeutics, Wave Life Sciences, and RegenxBio working on investigational therapies to address unmet needs. It also mentions Daiichi Sankyo's recent success with the approval of Astrazeneca-partnered Dato-DXD. Additionally, new treatments are in development for Achondroplasia to challenge Biomarin's Voxzogo. Novo's obesity drug shows promising results, Merck's Keytruda combo fails in a Phase III trial for GI cancer, and Tris Pharma wins late-stage for a non-opioid painkiller. The text also invites feedback from readers on topics they would like to see covered in the future.

Welcome back to All Villans, where we meet a diverse range of Aston Villa fans all over the world.Today, we meet Chad Williams, who hosts the Villa4Ever Podcast. We talk about Aston Villa's start to the season, the upcoming Fulham game, and Chad's aim to raise awareness of his condition Duchenne Muscular Dystrophy (DMD).PLEASE SPONSOR CHAD & MICHAEL HUGGINS' FUNDRAISER FOR ACORNS CHILDREN'S HOSPICELINK: https://www.justgiving.com/page/michael-huggins-1728467369005?utm_medium=fundraising&utm_content=page%2Fmichael-huggins-1728467369005&utm_source=copyLink&utm_campaign=pfp-shareFOLLOW US AND SUBSCRIBE ONLINE!WEBSITEwww.allvillanofiller.comGET IN TOUCHYouTube: Search All Villa No FillerTwitter: @VillaNoFillerInstagram: @allvillanofillerFacebook: All Villa No FillerEmail: allvillanofiller@gmail.comHOSTS: George Zielinski (@ZielinskiGeorge) / Frankie Maguire (@FrankieMaguire)PRODUCTION: Frankie Maguire#avfc #utv #astonvilla #football #villapark #soccer #CHAMPIONSLEAGUE Hosted on Acast. See acast.com/privacy for more information.

Elijah Stacy, founder of Destroy Duchenne, sits down with Frank Gleeson, co-founder and CEO of Satellos Bioscience, to explore the vision and leadership that have driven Satellos to the forefront of regenerative medicine. In this episode, we dive into Frank's personal journey, the foundational ideas behind Satellos, and the pivotal moments that shaped the company's mission to revolutionize treatments for muscular dystrophy. This conversation highlights the strategic decisions and innovations that continue to propel Satellos toward its goal of pioneering novel therapies for Duchenne Muscular Dystrophy. Learn More about Satellos: https://satellos.com Want to be on the podcast? Click here: https://www.destroyduchenne.org/podcast Learn more about the Destroy Duchenne Podcast here: https://www.destroyduchenne.org/podcast Website: https://www.destroyduchenne.org Social Media: Facebook: https://www.facebook.com/destroyduchenne Instagram: https://www.instagram.com/destroyduchenne Twitter: https://twitter.com/destroydisease LinkedIn: https://www.linkedin.com/company/destroyduchenne ABOUT DESTROY DUCHENNE PODCAST: The Destroy Duchenne Podcast is a platform dedicated to telling the stories of those affected by Duchenne Muscular Dystrophy (DMD), a devastating muscle-wasting disease. Hosted by Elijah Stacy, a 23-year-old founder of Destroy Duchenne and a DMD patient himself, this podcast seeks to bring attention to the fight against DMD by interviewing those closest to the disease—patients, families, doctors, and researchers. Destroy Duchenne is a registered 501(c)(3) nonprofit organization with a mission to complete the cure for Duchenne Muscular Dystrophy by advancing medical technologies into human practice. Federal Tax ID: #82-3268952

Welcome to our latest episode of the Green Sunrise Podcast!

Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma e Biotech world. Steward Health plans to lay off over 1,200 workers in Massachusetts and close two hospitals. Walgreens has reduced its stake in Cencora for $1.1 billion. The cost of healthcare data breaches is nearly $10 million in 2024, making healthcare the most expensive industry for data breaches. Employers are enhancing healthcare benefits despite rising costs, and Medicare has finalized a higher 2.9% inpatient payment rate for 2025. Virtual reality, robotics, and AI are transforming patient engagement, staff burnout, and clinical decision-making in the healthcare industry. Hospitals remain dissatisfied with Medicare's final rule despite the bump in payment rates.On August 5th, J&J launched the Velys spine surgical robotics and navigation platform, while Inspire received FDA approval for obstructive sleep apnea neurostimulator therapy. Philips is suing an independent lab over alleged errors in CPAP foam tests. Compliance hurdles with the FDA's lab developed test rule raise concerns about patient harm. The board of 23andMe rejected CEO Wojcicki's take-private proposal. J&J aims to compete with Stryker and Zimmer Biomet with its new surgical robotics portfolio. Inspire plans to launch its neurostimulator therapy device late in 2024. Philips claims an independent lab overestimated the threat of CPAP foam, leading to unnecessary recall efforts.Bristol Myers has halted Tigit drug research, while Lilly has resolved the shortage of Zepbound and Mounjaro. Biotech IPOs are vital for industry growth, with companies like Os Therapies and Actuate Therapeutics making moves in the market. Cell therapy is advancing in cancer care despite limited uptake, with biotech companies investing in its improvement. Pfizer discontinued late-stage gene therapy development for Duchenne Muscular Dystrophy (DMD), but other companies like RegenxBio and Capricor Therapeutics are making progress with their therapies. Oncology research is introducing new treatments like cell and gene therapies, revolutionizing cancer treatment.BioNTech reported a significant increase in losses in the second quarter of 2024, jumping to nearly $885 million compared to $208.5 million last year. The company is focusing on oncology amidst the impact of COVID-19. Lilly's drugs Mounjaro and Zepbound are no longer in shortage, according to the FDA. Bristol Myers Squibb is backing out of a $1.5 billion deal with Agenus for a bispecific antibody program, while Bayer's finerenone met its primary endpoint in a phase III heart failure trial. The pharmaceutical industry continues to see developments in various therapeutic areas, including Alzheimer's disease and rare diseases.Support the Show.

In this installment of our series on rare neurologic diseases, host Ken Vinacco talks with Claudia Senesac about physical therapy for people with Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD). DMD and BMD are both disorders that cause progressive muscle weakness, with BMD often presenting with less severe weakness and later in life. Claudia covers the medical management and prognosis, PT assessment, and PT treatment for people with these unique diagnoses.  The Degenerative Diseases Special Interest Group is part of the Academy of  Neurologic Physical Therapy – www.neuroPT.org  A link to the show notes will be posted here when available

Discover how innovative gene therapies are being used to treat and improve the quality of life for children with Duchenne Muscular Dystrophy (DMD).

Percheron Therapeutics Ltd (ASX:PER) managing director and CEO James Garner sits down with Proactive's Jonathan Jackson for a comprehensive update of the company and its focus on treating rare diseases, including the advancement of its lead program, ATL1102. Percheron is dedicated to developing therapies for conditions with high unmet medical needs, particularly emphasising its efforts on Duchenne Muscular Dystrophy (DMD), a rare and severe muscle-wasting disease. Garner provides an update on ATL1102, highlighting its promising progress in clinical development and the commercial opportunity presented by the need for effective DMD treatments. Percheron is well-funded for its upcoming initiatives, with a strong focus on advancing its pipeline towards market readiness. Garner also outlines the company's strategic path to market, which includes ongoing development work and the exploration of partnership opportunities to enhance ATL1102's commercial viability and accessibility. The company's participation in the Annual Clinical and Scientific Conference of the Muscular Dystrophy Association was marked by three poster presentations. Garner highlighted the importance of this involvement, detailing the significant findings presented and their relevance to the broader scientific and medical community's understanding of DMD and potential treatments. Finally, he outlines the investment case for Percheron, emphasising the company's unique position in addressing rare diseases with significant unmet needs. #ProactiveInvestors #PercheronTherapeutics #ASX #biotech #DuchenneMuscularDystrophy #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

When he founded Cure Rare Disease in 2018, Rich Horgan was primarily focused on finding a treatment for his younger brother Terry, who had an ultra-rare form of Duchenne Muscular Dystrophy (DMD).   Suffering from a disease that has no cure, Terry served as a “selfless, brave, and courageous” figure that Rich continues to draw inspiration from when seeking new, innovative solutions to treat this progressive, neurodegenerative condition.   Join us for this interview as Rich discusses the origins of Cure Rare Disease, Terry's ongoing legacy, the collaborative effort it takes to advance the drug development journey, the important role of the patient voice when developing treatments, and the future of rare disease research.  Show Notes What We Owe Terry Horgan: Reflections from Providers, Family, and Scientists Letter From Terry's Parents The Disruptors - Meet Rich In Vitro Assays for Duchenne Muscular Dystrophy 2022 World Congress Video Duchenne Muscular Dystrophy Studies Rare Disease Research for Drug Development Scientific Collaboration Leads to Faster Drug Development Cure Rare Disease   

In this Episode, Chris McCurley and Jonah Marlin discuss the “Meaning of Life.” In January of 2009 Jonah and his brother were diagnosed with Duchenne Muscular Dystrophy(DMD) at the ages of 5 and 2. DMD is a horrible disease that is fatal 100% of the time with no current cure. This disease affects 1 in 3500 boys born each year with no ethnic or geographical boundaries. Have questions? Email chris.mccurley@rippleoflight.com.   Learn More: http://www.fightdmd.com   This Podcast is Produced by Ripple of Light Ministries. Ripple of Light Ministries spreads news of the gospel throughout the world using various multimedia tools.   Our nonprofit was founded in 2016 and offers programs at-no-cost through this website, YouTube, Facebook and other online sources. A combination of podcasts, single-issue programs and series are available on many topics.   To find our more check our our website at rippleoflight.org 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.23.546309v1?rss=1 Authors: Xuan, W., Cheng, F., Han, X., Tipparaju, S., Ashraf, M. Abstract: Background: Extensive studies have been conducted in skeletal muscle and myocardium affected by Duchenne Muscular Dystrophy (DMD) disease but there is a significant gap of research in the role of vascular smooth muscle cells (VSMCs) in DMD. Here, we investigated the role of dystrophin deficiency in the maintenance of VSMCs contractile phenotype. Methods: 12-14 months old mdx mice and DMD induced pluripotent stem cells (iPSC) derived VSMCs were used as disease models. Morphological and immunohistochemistry analyses were performed to determine histological changes and the expression of contractile markers. Transmission Electron Microscopy (TEM) was used to assess ultrastructural changes in the VSMCs. Mito-tracker staining and TUNEL staining were performed to determine mitochondria fission-fusion and apoptosis respectively. mRNA Sequencing for normal iPSC derived VSMCs (WT-VSMCs) and DMD iPSC derived VSMCs (DMD-VSMCs) with or without oxidative stress was performed. KEGG signaling pathway enrichment, Go function enrichment and Gene set enrichment analysis (GESA) were conducted to explore the potential mechanism responsible for these changes. In addition, transcription factor enrichment analysis was performed to unravel mechanistic pathways of regulatory networks. Results: Spontaneous abnormal VSMCs proliferation, loss of vascular structure and degenerative changes occurred in VSMCs in aorta from 12-14 months old mdx mice. The DMD-VSMCs showed maturation defect, loss of mitochondrial hemostasis, and increased vulnerability to oxidative stress compared with WT-VSMCs. Transcriptome analysis revealed dysregulation of smooth muscle proliferation, differentiation, and vascular development in DMD-VSMCs. Transcriptional factor, target, and motif discovery analysis of the dysregulated gene set suggested potential contributions of transcriptional factors GADD45A, SOX9, TIA1, RBBP9 and FOXM to the phenotypes of DMD-VSMCs. Under oxidative stress, initiation of apoptotic process was significantly enhanced in DMD-VSMCs while their response to hypoxia and oxidative stress was downregulated. Conclusions: Dystrophin deficiency induced VSMCs phenotype switching and disrupted mitochondrial metabolism. The findings in this study underscore the importance of vascular dysfunction in DMD disease and therapeutic interventions to restore VSMC phenotype may ameliorate the propensity of disease progression. It is suggested that the transcriptome analysis may allow the discovery of potential signaling pathways involved in the dysregulation of transcription factors. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

For Rare Disease Day 2023, we were honored to moderate a virtual panel with our friends at Jett Foundation.  The theme was Thriving with Duchenne; a Rare Disease Day event focused on mental health and anxiety and it features a diverse panel of patients, caregivers, a life coach, and a Psychologist.  Duchenne Muscular Dystrophy (DMD) affects mostly males and causes progressive muscle damage in the entire body. It is the most common fatal pediatric disorder.  Duchenne has no cure. But the individuals in this episode are determined to Thrive with Duchenne.  

Cardiomyopathy Associated with Duchenne Muscular DystrophyIn this episode with Dr. Linda Cripe, we learn more about cardiomyopathy associated with Duchenne Muscular Dystrophy (DMD). We discuss care consideration and management strategies especially pertinent for manifesting DMD carriers and why screening and monitoring is so important. What more could be done to support carrier moms? Listen to the podcast to learn more.US-DMD-0303 I February 2023PTC Therapeutics has provided financial compensation to Dr. Cripe for the time to conduct this interview.Trademarks, registered or otherwise, are the property of their respective owner(s).© 2023 PTC Therapeutics, Inc. All Rights Reserved Hosted on Acast. See acast.com/privacy for more information.

Everyone has faced adversity at some point in their life, especially in recent years with the Covid pandemic. But we all handle adversity differently. Lousin Mehrabi found herself faced with unimaginable adversity: Her six-year-old son was diagnosed with Duchenne Muscular Dystrophy (DMD).  DMD is an incurable genetic disorder characterized by progressive muscle degeneration and is life-limiting. Lousin was faced with a choice: How was she going to face this news? In this episode of Negotiations Ninja, Lousin talks about how you use your negotiation skills to face adversity.  Outline of This Episode [1:53] Learn more about Lousin Mehrabi [2:52] How to negotiate with yourself [5:07] Get clear on your “why” to remove limiting thoughts  [6:00] You can unconsciously derail a negotiation  [7:29] Diagnose the problem before you try to solve it [12:14] You have to understand the language of your counterpart [16:15] Using negotiation skills to face adversity  Connect with Lousin Mehrabi Connect with Lousin on LinkedIn The Life Negotiations Podcast Lousin's YouTube channel Connect With Mark Follow Negotiations Ninja on Twitter: @NegotiationPod Connect with Mark on LinkedIn Follow Negotiations Ninja on LinkedIn Connect on Instagram: @NegotiationPod Subscribe to Negotiations Ninja

Women & DuchenneWe are dedicating this episode to ‘Women & Duchenne' in honor of World Duchenne Awareness Day which takes place every September 7. Tune in to hear from three incredible women: a clinical expert, a mother who is also a carrier and caregiver, and a scientist share their knowledge, perspectives and experiences. Each has a set of unique challenges to overcome in order to manage Duchenne Muscular Dystrophy (DMD). US-DMD-0294 I November 2022PTC Therapeutics has provided financial compensation to Elizabeth Floyd and Dr. Cripe for the time to conduct this interview.Trademarks, registered or otherwise, are the property of their respective owner(s).© 2022 PTC Therapeutics, Inc. All Rights Reserved Hosted on Acast. See acast.com/privacy for more information.

When a rare genetic disorder hits home, it takes someone like this week's Team Never Quit Podcast guest, Stephanie Herzog, to help find strategies to cure it. The Duchenne Muscular Dystrophy (DMD) diagnosis of her son, Max, was the driving force to connect her with Cure Rare Disease, who is currently developing life-saving therapeutics in collaboration with the world's leading academics, clinicians, regulatory experts, translational experts, and manufacturing experts. Stephanie serves as a board member. The organization's ground-breaking research is bringing to fruition the potential for permanent muscular regeneration, which was, at one time, science fiction. In this episode you will hear: When we learned about our son's condition, we put together a golf tournament to raise funds because it was A: Our only option, and B: Our best option to cure our kid.  80% of boys with Duchenne Muscular Dystrophy have a gene deletion in the dystrophin gene. Max has a duplication of the dystrophin gene. In what should be the best time ever with your child, that's when we find out he has this horrible disease. We had like a funeral in our house for like a month.  The weight of his future was heavy. Our team, through Crispr technology, hope to edit Max's gene mutation. 6 years ago, this was science fiction. Boys usually get diagnosed between the ages of 4-6. They lose their ability to walk between the ages of 10 and 12. They usually lose their battle in their early 20s. They're literally knocking out the gene duplication along a string in his DNA on the cellular level. Using the Crispr technology, the muscle cells are auto-correcting, producing dystrophin on their own. You wonder: “How am I going to live with this? And you do.” Faith is everything. You need somebody to pray to. When the going gets tough they have prayer.

Nicole Hunter is a 30 year old woman from Virginia who is affected with Duchenne Muscular Dystrophy (DMD). She first became pregnant September 2020 and with no known family history of genetic diseases, it was a shock when it was discovered she was a carrier for DMD at routine genetic testing done at 12 weeks prenatally. At the same time, she found out she was also having a baby boy. Nicole proceeded to meet with a genetic counselor and made the decision to have an amniocentesis at 16 weeks to see if her child was affected with DMD. She got the results back at 21 weeks and she learned her baby boy was affected with Duchenne Muscular Dystrophy. Nicole and her family decided the right choice for them was a TFMR. Two days later, in February 2021, she had the procedure at 22 weeks pregnant. She is currently in the midst of her IVF journey in hopes of having a child unaffected by the condition. This is her story. As a disclaimer, this podcast series features sensitive topics. Understand that the opinions and topics do not express or represent the organizations personal feelings on any matter but are here to solely share the guest speaker's journey and life's experiences. These opinions and stories are theirs and theirs alone.

最近，基因編輯技術 CRISPR-Cas9 歡慶發表十週年，這個應用在 2020 年獲得了諾貝爾化學獎的至高榮譽，除了迅速成為基礎科學研究中的重要工具，基因編輯技術也被應用在許多前贍的藥物開發上。 閔譯立博士 (Yi-Li Min) 在博士班期間就開始進行基因編輯技術與杜興氏肌肉營養不良症（Duchenne Muscular Dystrophy, DMD）的研究。畢業後，她將研究帶到新創公司 Exonics Therapeutics 進行新藥開發，該公司隨後被 Vertex Pharmaceuticals 收購。譯立也加入 Vertex 帶領團隊開發基於基因編輯技術的 DMD 療法。本集「生技來一刻」，除了介紹了基因編輯技術、此技術在藥物開發上的應用，以及譯立獨特的職涯歷程。 求學、職涯簡介 (1:30) 基因編輯技術 (8:00) 基因療法與基因編輯療法 (10:05) 藥物遞輸 (drug delivery) 方法 (12:40) 基因編輯修復的特性 (15:35) Duchenne Muscular Dystrophy (DMD) 與基因編輯 (17:54) 基因編輯用於其他的疾病 (24:53) 脫靶 (off-target) 效應的評估 (27:50) 基因編輯療法的優勢與挑戰 (30:27) 將學術研究帶到新創公司的經驗 (33:00) 罕見疾病研究 (35:50) 在不同的單位執行計畫的角色定位 (40:15) 帶領大團隊的方法 (45:15) 短中期的職涯規劃 (48:03)

This episode is dedicated to discussing Duchenne Muscular Dystrophy (DMD) continuum of disease with a focus on cardiopathology. Hear from our expert guest speaker, Dr. Villa about the importance of continuing standard of care guidelines to support cardiac health. Chet Villa, MD is a Pediatric Cardiologist at Cincinnati Children's Hospital Medical Center. US-DMD-0277 I June 2022PTC Therapeutics has provided financial compensation to Dr. Villa for the time to conduct this interview. Trademarks, registered or otherwise, are the property of their respective owner(s). © 2022 PTC Therapeutics, Inc. All Rights Reserved Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

This episode is dedicated to discussing Duchenne Muscular Dystrophy (DMD) continuum of disease and importance of continuation of care. Hear from our expert guest speaker, Dr. Mayer about the recommended DMD standard of care guidelines with regards to ongoing patient management and care. Oscar Henry Mayer, MD is a Professor of Clinical Pediatrics at The Perelman School of Medicine at the University of Pennsylvania, and an Attending Pulmonologist within the Division of Pulmonology at the Children's Hospital of Philadelphia (CHOP). US-DMD-0276 I April 2022PTC Therapeutics has provided financial compensation to Dr. Mayer for the time to conduct this interview. Trademarks, registered or otherwise, are the property of their respective owner(s). © 2022 PTC Therapeutics, Inc. All Rights Reserved Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

Physiotherapy input for a child with Duchenne Muscular Dystrophy (DMD) is important. In this episode we talk with Katy De Valle, a physiotherapist, about what physiotherapy for DMD can look like and how the role of a physiotherapist changes as DMD progresses.

Wheeled devices for children with Duchenne Muscular Dystrophy (DMD) should be considered early. In this episode we chat with Justine Adams, a Physiotherapist, about the aim of wheeled mobility, what this looks like as DMD progresses and tips for discussing these mobility devices with families. The Education Hub has a new podcast show, Teach Think Treat. The show focuses on clinical education in a busy clinical setting. The first episode will air Friday the 18th of March, with our new host Steve Lacey, talking about teaching and learning with students on clinical placement at the RCH.

In this episode we chat with Kate Carroll, a physiotherapist, about the importance of calf length management in children with Duchenne Muscular Dystrophy (DMD). We discuss how to measure calf range and the management of this including stretches and night ankle foot orthosis (AFOs).

In this episode Rachel Kennedy, a physiotherapist, discusses the benefits and precautions for children with Duchenne Muscular Dystrophy (DMD) participating in physical activity. She also provides examples of safe physical activities and strategies for therapists working with children with DMD.

In this episode we discuss what health professionals should know about Duchenne Muscular Dystrophy (DMD). Kate Carroll, a physiotherapist, talks about the cause, clinical signs and treatments for DMD.

In this episode, you will hear from Dr. Michele Lloyd-Puryear talk about the diagnosis process and current intervention for Duchenne Muscular Dystrophy also known as DMD. We will learn how parent lay advocacy group plays a role in NBS and NBS research. Whether you're a parent, health professional, researcher, or advocate, there are many ways to get involved with NBS research Michele Lloyd-Puryear, MD, PhD, is a pediatrician and geneticist and has held academic appointments and has worked in pediatric clinics at the local and international levels. She is a Fellow of the American Academy of Pediatrics and an Emeritus Member of the American College of Medical Genetics and Genomics. Over her 40-year commitment to infants, children, and mothers, she has made numerous contributions internationally and nationally to programs that have improved and expanded the quality, services, and scope of the NBS and the care for children identified through NBS. Recognition for her work in maternal and child health, genetics services and NBS include awards from HHS, the Association of Public Health Laboratories; the March of Dimes; the Genetic Alliance and the Sickle Cell Disease Association of America. Interview Questions: What is Duchenne Muscular Dystrophy (also known as DMD)?     How about babies diagnosed for DMD and what are the current interventions?      You have an MD and a Ph.D. and are trained as a pediatrician and geneticist. How did you get involved with newborn screening research?  What role do parent lay advocacy groups play in newborn screening and NBS research?   How can parents, health professionals, and researchers get involved in NBS research for DMD?  You have played a variety of roles in NBSTRN. What areas do you see NBSTRN can play a role in NBS research?  What does NBS research mean to you?  To learn how to get involved in newborn screening research, visit www.nbstrn.org . 

In this episode, our guest speaker Dr. Diana Castro, Associate Professor of Pediatrics, Neurology and Neurotherapeutics at the University of Texas Southwestern shares her extensive clinical knowledge and discusses the clinical, diagnostic and medical landscape in DMD, as well as management approaches in the care of DMD. Diana Castro, M.D., is a neurologist at Children's Health℠ who specializes in pediatric neurology and neuromuscular medicine. She is also an assistant professor of pediatrics and neurology and neurotherapeutics at UT Southwestern Medical Center. She is the co-director of the Muscular Dystrophy Association Clinic in Dallas and is involved in multiple research protocols for spinal muscular atrophy (SMA) and Duchenne muscular dystrophy in the pediatric population. PTC Therapeutics has provided financial compensation to Dr Castro for the time to conduct this interview. US-DMD-0252 I 09/28/21 Trademarks, registered or otherwise, are the property of their respective owner(s). © 2021 PTC Therapeutics, Inc. All Rights Reserved. See acast.com/privacy for privacy and opt-out information.

Texas A&M University has endured several years of harassment and intimidation by PETA and their followers, including Sir Paul McCartney, based on claims made by PETA about how dogs involved in Duchenne Muscular Dystrophy (DMD) research are treated at this university. And, while many of us support research aimed at improving the lives of children and dogs affected by this devastating and terminal disease, we are also animal lovers who struggle in our hearts with what we've been told by PETA. I think concerns about animal welfare in research are both legitimate and loving; and I think we should know what these animals experience for the benefit of others. Our guest today is a veterinarian who worked directly with the DMD dogs, their caregivers and the research team at Texas A&M University. Today you will hear what few people can or will share about the experiences of these animals, so you can assess your beliefs and values within the full context of reality and truth. Given what we learned in our last episode from Trina and Pam, both mothers of boys with DMD, there's a lot to consider.

Joining our host, Kira Dineen, is Rich Hogan. Rich is the Founder and President of Cure Rare Disease, a company that develops customized therapeutics for those who have been diagnosed with rare, genetic diseases that have no treatments or cures. On this episode, we specifically sat down to discuss Duchenne Muscular Dystrophy during DMD awareness month!Rich Hogan has a deep passion for reimagining how rare and ultra-rare diseases are treated. With a younger sibling impacted by a rare disease, Rich has a strong interest in accelerating promising treatments for rare diseases. He formed an interdisciplinary collaboration of world-class researchers and clinicians to pioneer the rapid development of customized therapies for rare, genetic diseases. Prior to making his foray into biotech, Rich had extensive experience working in new business development at Corning Incorporated where he led the successful launch of a new product line. He also launched a successful car washing business in New York. He holds a BS from Cornell University where he graduated summa cum laude and an MBA from Harvard Business School where he was awarded the Blavatnik Fellowship for Life Science Entrepreneurship. Rich was recognized by Business Insider as one of ‘30 leaders under 40 transforming healthcare in 2020' and, most recently, was named on the 2021 Forbes 30 under 30 list.On This Episode We Discuss:Patient advocacy DMD heredityFounding Cure Rare Disease Current and developing treatments for DMDIn-vitro versus in-vivo researchNeutralizing antibodies To learn more about Rich, DMD, and Cure Rare Disease at cureraredisease.org. If you live in Canada, check out Muscular Dystrophy Canada at muscle.ca, which serves 50,000 Canadians impacted by neuromuscular disorders themselves, family members/caregivers, healthcare professionals, and researchers. They support individuals impacted by neuromuscular disorders by investing in research, delivering critical programs and services, and challenging public policy.Genomenon is a genomic health IT company powering precision medicine with genomics. Genomenon has designed the Mastermind Genomic Search Engine, which is used by hundreds of genetic labs worldwide to accelerate diagnosis, increase diagnostic yield, and assure repeatability in reporting genetic testing results. Genomenon also created the Mastermind Genomic Landscapes to inform pharmaceutical and bio-pharma companies on precision medicine development and deliver genomic biomarkers for clinical trial target selection. Look out for our October 1st episode, the founder of Genomenon will be a guest on DNA Today to explore the genetics of ALS. Learn more about Genomenon at genomenon.com (SPONSORED). If you enjoy DNA Today you will also love Eureka's Sounds of Science, a podcast from Charles River. Sounds of Science tells the stories of how – how chicken eggs impact vaccine development; how a single parent can change the FDA; how a horseshoe crab saves lives. If you enjoyed our episode (#74) with Huntington Disease patient advocate Antonio Maltese, you should check him out in this episode of Eureka's Sounds of Science podcast! Listen to Eureka's Sounds of Science on Apple Podcasts, Spotify, or wherever you download your podcasts. (SPONSORED)Stay tuned for the next new episode of DNA Today at the end of September where we'll be recapping the NSGC Annual Conference! Follow Us On...Instagram: @DNAradio (https://www.instagram.com/dnaradio/)Twitter: @DNApodcast (https://twitter.com/DNApodcast)Facebook: @DNApodcast (https://www.facebook.com/DNApodcast/)Listen On…Spotify (https://spoti.fi/39hVSUD) Apple (https://podcasts.apple.com/us/podcast...) Google (https://podcasts.google.com/feed/aHR0...) DNApodcast.com *******DNA Today is a podcast and radio show exploring genetics' impact on health through conversations with leaders in genetics like genetic counselors, researchers, doctors, and patient advocates. The show started in 2012 and features over 150 episodes. DNA Today won the 2020 Best Science and Medicine Podcast Award with nominate four other years. DNA Today is broadcast every Friday at 10:30am ET on WHUS 91.7 FM in Connecticut. New episodes are released on the first and third Friday of the month with some bonus episodes on other Fridays.

Is it ethical to do biomedical research with animals to improve the health of others? People for the Ethical Treatment of Animals (PETA), and other groups that oppose studies of this kind, are unequivocal in their belief that it is not. These groups continue to have a powerful influence over the feelings and beliefs of millions of people worldwide, including celebrities, lawmakers, educators, and media reporters with their own spheres of influence over public opinion. And their guidance may not serve us all equally. Our guests today are Trina and Pam, both mothers of sons with Duchenne Muscular Dystrophy (DMD) - and both animal lovers. As you will hear, research on DMD with animals is important to them for a variety of reasons. Is it possible to love animals and also support their use in biomedical research? We know what PETA believes, but are unequivocal positions about the ethics of animal research realistic for the rest of us? Please drop me a line after the episode at: getrealpodcast.info. I'd love to know your thoughts.

In this week's episode, I am chatting with Kasha Mitton and Maggie Aynsley. They are the founders of The MASH Movement, a platform that raises awareness about Duchenne Muscular Dystrophy (DMD). They inspire and mobilize their community with a focus on movement, awareness, service, and health. Kasha's son is living with DMD, and she helps us understand disease, where Canada stands in fighting it, and the importance of creating awareness. They explain their mission of being the voice of DMD and supporting patients and families. Kasha and Maggie are incredible humans, and I am so honoured to be introducing them to you. You can read the full show notes including timestamped highlights, their bio, and contact details, go to www.momcamplife.com/podcast.

"At first, it's all a big whirlwind and you can't process the big bombshell that you've been given. Suddenly, it turns out the life you had mapped out is not going to be like that at all. Almost overnight, you become a geneticist, you become a physiotherapist, you become a nurse, you become a dietitian. You are now the expert." Shelley is mum to Fraser, whose medical journey has been tough because he didn't have typical symptoms for any known conditions. But genetic testing found he had an alteration in one of his genes, leading to his diagnosis of Duchenne Muscular Dystrophy (DMD). As a family they later joined the 100,000 Genomes Project to find out why Fraser's non-textbook symptoms meant he didn't fall neatly into a faster DMD diagnosis. In this episode, Chris and Shelley talk about the lived experience of families managing a rare disease, climbing Snowdon, and being active in supporting disability rights.

The Mash Movement: Movement, Awareness, Service and Health, Bringing Awareness and Hope to Muscular Dystrophy with Kasha Mitton and Maggie Aynsley   Episode 20: Show Notes.   Their love for movement, combined with the introduction of Duchenne Muscular Dystrophy (DMD) into their lives, and their desire to create meaningful change, drove two best friends to found The Mash Movement. Although Kasha Mitton's son's diagnosis of DMD is painfully challenging, she and Maggie Aynsley choose to live in hope and optimism in the face of this tragedy. In Canada, little is known about DMD, and there are no approved treatments. The Mash Movement raises awareness around this rare neuromuscular disorder through storytelling and movement - not only movement in the physical sense, but in the emotional realm too. Their goal is to be there for people who are suffering all kinds of hardships, and their adopted mantra is “start where you are, use what you have, do what you can.” Their passion for their cause and gratitude for each other is inspiring, as you will hear today. Make sure you have a box of tissues nearby for this equally heartbreaking and heartwarming episode.    Key Points From This Episode:   “Start where you are, use what you have, do what you can” - Arthur Ash. Maggie and Kasha introduce themselves and what they are hoping to achieve with The Mash Movement. The meaning behind the Greek symbol which can be found in their logo. Factors which led to the founding of The Mash Movement, slightly over a year ago. Their biggest accomplishment so far: 25 days of Live in the Movement. Learn about Duchenne Muscular Dystrophy (DMD), the neuromuscular disorder which Kasha's son, Jude, suffers from. The lack of a collective voice and approved treatments for DMD in Canada, although they do exist elsewhere. Support being shown for The Mash Movement from all over. Maggie explains why storytelling has become an important part of The Mash Movement. The story behind Jesse's Journey, the only charity in Canada focused on research for a cure for DMD. Chapters in The Mom Babes book that Maggie and Kasha have written. Life has thrown them huge challenges but Maggie and Kasha maintain hope and optimism. An emotional sharing of the qualities that Kasha and Maggie admire in each other and their feelings about life. Gratitude for their community. The online yoga class, in collaboration with Free Flow, that you can join on Earth Day (and why you should!).   Tweetables:   “Movement brought up together. It's our language of healing.” — Kasha Mitton [0:00:35]   “We truly believe in hope. Not just for those suffering from Duchenne but for anyone who is journeying through hardship.” — Maggie Aynsley [0:04:38]   “Every day, little by little, if we can bring awareness [around DMD], because it's rare, because we don't have a collective voice.” — Kasha Mitton [0:13:27]   “Our ultimate goal is that we just continue being for other people. We're not “human doings”, we're human beings and we just want to be for other people. — Maggie Aynsley [0:20:21]   “It's not just about bringing people together through physical movement. It's about working people's muscles of compassion and empathy and generosity and just love for each other. Those are the muscles that we need in this world.” — Kasha Mitton [0:23:52]   Links Mentioned in Today's Episode:   The Mash Movement The Mash Movement on Facebook The Mash Movement on Instagram Duchenne Muscular Dystrophy CRISPR Jesse's Journey The Mom Babes Free Flow Emily Ratchford Britt Anderson Britt Anderson on Instagram   _________________________________________________ After years of bringing MOMS together by hosting evening get-togethers over glasses of wine, no kids or partners and a whole lot of common complaints, Brittany decided it was time to bring her female driven topics and #momdiscoveries to the podcasting platform. Here she talks all things life, health, fitness, kids, relationships – you name it, nothing is off the table! Diving deeper into all things motherhood & womanhood, she interviews some incredible guests finding tips and tricks, parenting hacks and longevity tips to make the most of our lives while keeping our sanity in check! It's time to get real, let go of the expectations we feel from the outside and begin to live a life of fulfillment. Show yourself some self love and take some selfcare time to listen in weekly! show notes found at www.momsweatsanity.com  

Movement Monday has two guests that have been longtime friends, Joel Wood and Wendell Moore, on the series to discuss Duchenne Muscular Dystrophy (DMD). Their friendship spans decades before becoming involved in this movement with working together in government to starting a restaurant with friends to moving to different capitals, their bond was never broken and continues to stay strong. The words “incurable” and “untreatable” are words no parent or person wants to hear but that’s exactly the words associated with Duchenne and for the many other forms of Muscular Dystrophy (MD). The Wood Family heard similar words when their son, James, was diagnosed in the early 2000’s and the family set out to change the words associated with the disease with the creation of the Foundation to Eradicate Duchenne Muscular Dystrophy. Duchenne Muscular Dystrophy is one of the most serious genetic diseases in children worldwide and this form typically only affects boys but there are other forms that can affect different areas of the body and can affect boys, girls, men, and women. Duchenne MD is the most common childhood form of MD, as well as the most common of the Muscular Dystrophies overall, accounting for approximately 50 percent of all cases. The Foundation to Eradicate Duchenne’s mission is to identify, leverage, and bring to market treatments that will benefit ALL sufferers of this disease. The advancements within the last 20 years for Duchenne Muscular Dystrophy is creating a huge shift. This shift is making better opportunities for patients and their families with DMD that will allow these boys to live better lives as well as how they can benefit other diseases by breaking the code on Duchenne Muscular Dystrophy. Foundation to Eradicate Duchenne Muscular Dystrophy (FED) https://www.duchennemd.org FED 2020 Annual Video https://vimeo.com/395684937 2020 Virtual Nashville Music Event: https://youtu.be/eYZeAWthff0 Social Media https://www.facebook.com/eradicateduchenne   _____________________________________________________________________________   Try Athletic Brewing, Brew without Compromise! (https://bit.ly/3aQ4u8n) Use RWD20 to receive 20% OFF your first order! Follow Dan’s journey at Ridewithdanusa.com Support Suicide Awareness and Dan’s Cause at Opaatmovement.com HOV©2021

Clinical experts discuss the importance of early detection and diagnosis of patients with Duchenne muscular dystrophy (DMD). Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/939476?src=mkm_podcast_addon_939476

Tiffany and Wil Cook share their experience living and coping with the diagnosis of Duchenne Muscular Dystrophy (DMD). When Will was homeschooled he turned to video games and has made many friends around the world. Tiffany discusses her work as Family Resource Manager with CureDuchenne and the inaugural virtual gaming tournament hosted by CureDuchenne and PTC Therapeutics on October 10 to connect gamers and people living with DMD across the country.

Hawken Miller is a journalist, streamer, and pro gamer. As young kids, he was diagnosed with Duchenne Muscular Dystrophy (DMD), a genetic disorder that results in progressive muscle weakness – most boys living with DMD do not survive beyond their mid-twenties, and those that do are typically in a wheelchair by age 12 and may experience social isolation. Over the past decade, video gaming has become a favored past time and he has discovered a career from it. ► Check out the video version: https://youtu.be/wBPMYjT0gUk Check out Hawken on ALL the social medias: https://twitter.com/hawkenmiller http://hawkenmiller.com/ SPONSERS: https://www.eliassoftware.com/ http://gameschoolonline.com/ ● Join our Discord: https://discord.com/invite/sJtGmpV ● Website: http://gamedevunchained.com ●Twitter: https://twitter.com/BLUchamps

Hawken Miller, 23, diagnosed with Duchenne Muscular Dystrophy (DMD) at age five discusses his personal journey and how he had turned to video games as an option to stay competitive and connected as his friends advanced in sports while his disease progressed. Knowing the critical role of gaming for people living with DMD, CureDuchenne and PTC Therapeutics are hosting an inaugural virtual gaming tournament on October 10 to connect gamers and people living with DMD across the country.

“Living with muscular dystrophy feels like you're founding a startup. You know exactly what you want to create, and yet you can't find one existing model on how to get there.” Today, we're going to dive into the world of scary diagnoses and how to push your path forward. We address: How do I navigate the status quo and bureaucratic considerations when starting a nonprofit? What realities should an aspiring entrepreneur accept before taking the leap? How do I stay focused on my mission as an entrepreneur in a fast-paced world filled with distractions? How do I effectively pivot my business amid the various effects of the pandemic? How can I build my brand through collaboration with others? Karen Morales welcomes Rich Horgan, Founder and President of Cure Rare Disease. A couple of months ago, we spoke about his journey to create the first nonprofit to cure muscular dystrophy with CRISPR technology. This week, Rich announced that Cure Rare Disease formally met with the FDA for the pre-IND meeting—the meeting that comes before drug approval. CRD received positive comments regarding their studies and their proposed plan to move forward ultimately into the clinic for the first customized therapeutic. Karen herself recalls the daily challenges of living with Limb-girdle muscular dystrophy type 2B. When she was diagnosed with the disease at age 20, she remembers receiving very little support beyond non-committal words of “encouragement” such as, “We'll figure this out someday,” or “The science isn't there yet.” The medical community has made leaps and bounds in dissecting the ins-and-outs of muscular dystrophy, and yet to Karen, things are almost no different from 1998. 22 years later and there is still no cure, no drug to halt or ease symptoms, no approved lifestyle changes, exercise programs, or even any agreed upon supplements. At last, a breakthrough may be on the horizon. Rich discusses how living with a younger brother with a super-rare and fatal form of muscular dystrophy inspired him to create his nonprofit, and how his path led him to announce that a cure for muscular dystrophy is finally in our sights.   3 MAJOR POINTS DISCUSSED The choice between entrepreneurship and a traditional career comes down to a few very specific moments. Consider the contract that comes your way, dictating the “reliable” salary you're to receive week after week as long as the business continues to operate. With entrepreneurship, the salary that you get (or don't get) is a function of your own performance—and for most people, this is a scary prospect. Entrepreneurship demands very high risk-tolerance. If you're able to accept and prepare for that fact that episodes of failure will become the norm, and that you'll be faced with a year's worth of runway at the beginning of your journey, it becomes easier to take the dive. There's nothing like the feeling you get once you see your vision turned to reality, when your plan is successfully executed, when your idea becomes applied. You may experience more “lows” in your career as an entrepreneur compared to a traditional employee, but on the other hand, the “highs” are likewise on a completely different level. Collaboration is COVID-proof. It's hard enough in normal times to maintain our focus on our goals as an entrepreneur, much less when we go on the journey alone. As much as we want to treasure our big idea and possibly even want to keep it under wraps until we're ready to execute, the fact of the matter is that collaboration with and support from other like-minded people always pushes our agenda forward. With Coronavirus disrupting literally every aspect of our lives, going at our entrepreneurial ventures alone simply won't get us anywhere in the long-term. Reach out to those you can make a difference to and receive support from in return. You never know what doors they can open for you and your business. RESOURCES Cure Rare Disease Rich Horgan is the Founder and President of Cure Rare Disease. He is an entrepreneur with a particular passion for Duchenne Muscular Dystrophy (DMD) and other rare diseases, motivated by a younger brother impacted by the disease.   Rich holds a BS from Cornell University where he graduated summa cum laude and an MBA from Harvard Business School where he was awarded the Blavatnik Fellowship for Life Science Entrepreneurship.   Connect with Rich on LinkedIn Follow him on Twitter   Karen Morales is founder and brand champion at Marketing Magnet. Marketing Magnet was founded by Karen and her lean team of Fortune 500 marketing and advertising talent. We're a world-class marketing department that has decided to take our big brand experience and direct it at the clients we want to serve: purpose-driven enterprises. Our secret sauce is our ability to focus companies on three marketing pillars to create great impact. If you are looking for a solution to a marketing challenge, a specific project to be completed or a team to drive marketing on your behalf, we can help. More about Karen Find us on Facebook Visit our website Find us on Instagram

“Living with muscular dystrophy feels like you’re founding a startup. You know exactly what you want to create, and yet you can’t find one existing model on how to get there.” Today, we’re going to dive into the world of scary diagnoses and how to push your path forward. We address: How do I navigate the status quo and bureaucratic considerations when starting a nonprofit? What realities should an aspiring entrepreneur accept before taking the leap? How do I stay focused on my mission as an entrepreneur in a fast-paced world filled with distractions? How do I effectively pivot my business amid the various effects of the pandemic? How can I build my brand through collaboration with others? Karen Morales welcomes Rich Horgan, Founder and President of Cure Rare Disease. A couple of months ago, we spoke about his journey to create the first nonprofit to cure muscular dystrophy with CRISPR technology. This week, Rich announced that Cure Rare Disease formally met with the FDA for the pre-IND meeting—the meeting that comes before drug approval. CRD received positive comments regarding their studies and their proposed plan to move forward ultimately into the clinic for the first customized therapeutic. Karen herself recalls the daily challenges of living with Limb-girdle muscular dystrophy type 2B. When she was diagnosed with the disease at age 20, she remembers receiving very little support beyond non-committal words of “encouragement” such as, “We’ll figure this out someday,” or “The science isn’t there yet.” The medical community has made leaps and bounds in dissecting the ins-and-outs of muscular dystrophy, and yet to Karen, things are almost no different from 1998. 22 years later and there is still no cure, no drug to halt or ease symptoms, no approved lifestyle changes, exercise programs, or even any agreed upon supplements. At last, a breakthrough may be on the horizon. Rich discusses how living with a younger brother with a super-rare and fatal form of muscular dystrophy inspired him to create his nonprofit, and how his path led him to announce that a cure for muscular dystrophy is finally in our sights.   3 MAJOR POINTS DISCUSSED The choice between entrepreneurship and a traditional career comes down to a few very specific moments. Consider the contract that comes your way, dictating the “reliable” salary you’re to receive week after week as long as the business continues to operate. With entrepreneurship, the salary that you get (or don’t get) is a function of your own performance—and for most people, this is a scary prospect. Entrepreneurship demands very high risk-tolerance. If you’re able to accept and prepare for that fact that episodes of failure will become the norm, and that you’ll be faced with a year’s worth of runway at the beginning of your journey, it becomes easier to take the dive. There’s nothing like the feeling you get once you see your vision turned to reality, when your plan is successfully executed, when your idea becomes applied. You may experience more “lows” in your career as an entrepreneur compared to a traditional employee, but on the other hand, the “highs” are likewise on a completely different level. Collaboration is COVID-proof. It’s hard enough in normal times to maintain our focus on our goals as an entrepreneur, much less when we go on the journey alone. As much as we want to treasure our big idea and possibly even want to keep it under wraps until we’re ready to execute, the fact of the matter is that collaboration with and support from other like-minded people always pushes our agenda forward. With Coronavirus disrupting literally every aspect of our lives, going at our entrepreneurial ventures alone simply won’t get us anywhere in the long-term. Reach out to those you can make a difference to and receive support from in return. You never know what doors they can open for you and your business. RESOURCES Cure Rare Disease Rich Horgan is the Founder and President of Cure Rare Disease. He is an entrepreneur with a particular passion for Duchenne Muscular Dystrophy (DMD) and other rare diseases, motivated by a younger brother impacted by the disease.   Rich holds a BS from Cornell University where he graduated summa cum laude and an MBA from Harvard Business School where he was awarded the Blavatnik Fellowship for Life Science Entrepreneurship.   Connect with Rich on LinkedIn Follow him on Twitter   Karen Morales is founder and brand champion at Marketing Magnet. Marketing Magnet was founded by Karen and her lean team of Fortune 500 marketing and advertising talent. We’re a world-class marketing department that has decided to take our big brand experience and direct it at the clients we want to serve: purpose-driven enterprises. Our secret sauce is our ability to focus companies on three marketing pillars to create great impact. If you are looking for a solution to a marketing challenge, a specific project to be completed or a team to drive marketing on your behalf, we can help. More about Karen Find us on Facebook Visit our website Find us on Instagram The post Rich Horgan: The Daily Contradiction of Living with LGMD appeared first on Momentum Magnet.

We loved meeting Charlie and his Dad last season.  At just 10 years old, Charlie has faced more battles than most of us will face in a lifetime.  Suffering from both Duchenne Muscular Dystrophy (DMD) and Persistent Hyperplastic Primary Vitreous (PHPV), he is blind in one eye and not readily mobile on his own.  Their mission? To raise funds for a new family vehicle to get him around in his powered wheelchair.  Well, we have an update! The good kind.  Listen to hear how it all unfolded! To follow their journey and donate, you can follow their journey on instagram at @fightingforcharlie See omnystudio.com/listener for privacy information. See omnystudio.com/listener for privacy information.

Monday, September 7th was World Duchenne Day, which seeks to raise global awareness for all those affected by Duchenne Muscular Dystrophy, an estimated 300,000 boys worldwide. Duchenne Muscular Dystrophy (DMD) is a genetic disease that destroys muscles. First, the legs go, then the upper body sags, and eventually the heart and lungs stop working. There is no cure. In 2016, the first medication to treat DMD was approved and while the medication was is not specific to all of the variations of DMD, families hope additional versions might be on the horizon. In this episode, Lara talks with 18-year-old Lucas Currier, of Exeter, who was diagnosed with DMD when he was 4 years old, and his mother Linda. --- Send in a voice message: https://anchor.fm/exeterlife/message Support this podcast: https://anchor.fm/exeterlife/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.31.230565v1?rss=1 Authors: Rousseau, J., Mbakam, C. H., Guyon, A., Tremblay, G., Begin, F. G., Tremblay, J. P. Abstract: Base editing technique and PRIME editing techniques derived from the CRISPR/Cas9 discovery permit to modify selected nucleotides. We initially used the base editing technique to introduce in the APP gene the A673T mutation, which prevents the development of Alzheimer disease. Although the desired cytidine to thymidine mutation was inserted in up to 17% of the APP gene in HEK393T, there were also modifications of up to 20% of other nearby cytidines. More specific mutations of the APP gene were obtained with the PRIME editing technique. However, the best percentage of mutations was only 5.8%. The efficiency of the PRIME editing treatment was initially tested on the EMX1 gene. A single treatment produced the desired modification in 36% of the EMX1 gene. Three consecutive treatments increased the percentage of mutations to 50%. The PRIME editing technique was also used to insert specific point mutations in exons 9 and 35 of the DMD gene coding for the dystrophin gene and which is mutated in Duchenne Muscular Dystrophy (DMD). Up to 10% desired mutations of the DMD gene were obtained. Three repeated treatments increased the percentage of specific mutations to 16%. Given that there are thousands of nuclei inside a human muscle fiber and that the dystrophin nuclear domain is about 500 microns, this level of modifications would be sufficient to produce a phenotype improvement in DMD patients. Copy rights belong to original authors. Visit the link for more info

Rich Horgan, How A Nonprofit Pharma Company Is Using CRISPR To Cure Muscular Dystrophy Many of us face challenging medical diagnoses, and those with rare diseases often get the news without any treatment options. Rich Horgan's family has been fighting his brother's Duchenne Muscular Dystrophy (DMD) diagnosis for over two decades. Rich's relentless dedication to helping his brother Terry led him to leave Harvard Business School to create the first nonprofit drug company to use CRISPR to cure DMD. Rich shares his journey, the future of personalized gene therapy and how he built an organization to save not only his own brother, but other patients fighting these incurable diseases.

Rich Horgan, How A Nonprofit Pharma Company Is Using CRISPR To Cure Muscular Dystrophy Many of us face challenging medical diagnoses, and those with rare diseases often get the news without any treatment options. Rich Horgan’s family has been fighting his brother’s Duchenne Muscular Dystrophy (DMD) diagnosis for over two decades. Rich’s relentless dedication to helping his brother Terry led him to leave Harvard Business School to create the first nonprofit drug company to use CRISPR to cure DMD. Rich shares his journey, the future of personalized gene therapy and how he built an organization to save not only his own brother, but other patients fighting these incurable diseases. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app The post Rich Horgan: How A Nonprofit Pharma Company Is Using CRISPR To Cure Muscular Dystrophy appeared first on Momentum Magnet.

At just 10 years old, Charlie has faced more battles than most of us will face in a lifetime.  Suffering from both Duchenne Muscular Dystrophy (DMD) and Persistent Hyperplastic Primary Vitreous (PHPV), he is blind in one eye and not readily mobile on his own.  His family are working tirelessly to both raise awareness, and funds for a new family vehicle to get him around in his powered wheelchair.  Amidst bushfires and now COVID-19 everyday Australians (both friends and strangers) have dug deep to make this dream a reality for Charlie so that he can get around and integrate into the community like a regular kid.  And they are so close to meeting their goal.  To follow their journey and donate, you can follow their journey on instagram at @fightingforcharlie See omnystudio.com/listener for privacy information. See omnystudio.com/listener for privacy information.

Rachel Poysky’s greatest fears about the health of her son, Joel, were affirmed when she pulled into the driveway and her husband was waiting for her with news. Her husband, Dr. James Poysky, delivered the grave news that their son did in fact have Duchenne Muscular Dystrophy (DMD). DMD is the most common fatal genetic disorder of childhood and it likely meant that their son wouldn’t live past high school. Rachel tells us about that day -- how they went from being a "normal family" to being a "special needs family."  But, that wasn’t the bottom for Rachel. A few years later, just as the family was regaining a sense of normalcy, their daughter was diagnosed with an even rarer disease, Kawasaki Disease. Rachel and her husband felt a calling with DMD, their family was uniquely positioned to make an impact, but Kawasaki Disease progressed rapidly and if it had not been diagnosed and treated, could have ended the life of their daughter within 24 hours. This was rock bottom. One of our teammates who helps on transcripts for this show said, “This one is another Tear-fountain! I can't imagine being in this woman's shoes!” What I found particularly insightful about this story was Rachel and James’ commitment to remaining aligned and supportive to one another as husband and wife. They gave each other space to grieve separately, but they were always together. Their relationship feels extraordinary to me. The Poysky family certainly answered the call. Dr. Poysky has been instrumental in a medical leadership role serving on national boards and authoring papers. And with Rachel’s brother Brad Todd, they created the non-profit Coach To Cure MD, a partnership between the American Football Coaches Association (AFCA), a professional organization for over 10,000 college and high school football coaches and staff, and Parent Project Muscular Dystrophy, the largest national charity devoted exclusively to Duchenne muscular dystrophy.  Season 2: For Love of My Child are true stories of a parent’s transformation when faced with acute challenges, chronic ills, and early endings of their child or children. What a season of life! Belly of the Beast Life Stories is a firsthand history of real life transformations. If you were moved by this episode, please subscribe, rate and write a fair review about this podcast so other heroes can find it, too. Share it with one or two friends. And visit inourbelly.com to listen to more stories for free and to share your story with us. MORE FROM DAVID ALL Underbelly Workshops: Connect the dots, master your story http://inourbelly.com/underbelly  Bringing to life the wisdom in your transformation journey through a clear and compelling story is essential to building a conscious business. Whether you are meeting a potential customer for your coaching or healing practice, recruiting talent for your growing business, or sharing your message with a larger audience, your personal transformation story is your greatest asset. We guide you back to this experience, helping you connect the dots in the transformation pattern, and master your story.  Beyond the Belly: A podcast about the healing patterns of transformation http://inourbelly.com/beyond Our newest podcast, Beyond the Belly, unpacks wisdom in the patterns of transformation. Expert friends of mine join to discuss topics coming across all of the stories in Belly of the Beast Life Stories. EPISODE SUMMARY The story starts with Rachel first learning from her husband, Dr. James Poysky, that her son had been diagnosed with Duchenne Muscular Dystrophy (DMD) At the time, her husband had been a neurosphychologist and suspected that it could be DMD because he had seen it in children before DMD is the most common fatal genetic disorder of childhood, but it’s still a rare disease since it affects less than 200,000 people Duchenne primarily affects boys but women can be carriers; and it can be spontaneous (genetic mutation) as was the case with Rachel’s family Rachel shares the “language of Duchenne” which is this entirely new vocabulary that comes with the territory of rare diseases It also means talking to your children about the disease so they have the “tools and knowledge to function” A week after the diagnosis, Rachel and her husband aligned on their purpose, that they were meant to join the Duchenne fight Two weeks after the diagnosis they aligned on the priorities that still guide their family to this day Rachel’s daughter Hallie was diagnosed with an even rarer disease, Kawasaki Disease A special needs family starts out in “survival mode” but Rachel consciously made the decision to live life with her family Rachel is an expert in grieving and discusses the idea that people don’t grieve and can’t be expected to grieve in the same way Rachel discusses the origins of CoachtoCureMD.org, the charity they created to help raise funds and awareness for DMD QUOTABLES “And it's almost that moment when I pulled into the driveway, I didn't even have to ask the question why he was there at 3:00 in the afternoon. And I walked up to the door and he met me at the door. And I just said, "Is it that?" And he said "Yes." And I said, "The really bad kind?" And he said, "Yes." And that was a moment when we went from being a normal family to a special needs family, just all of a sudden.”   “They're missing dystrophin which, this is simplistic, and a doctor would probably be horrified that I explained it this way, but basically dystrophin is the glue that hold your muscles together. And when you exercise, you tear your muscles and the dystrophin helps repair them. They don't have any dystrophin so their muscles can't repair, so scar tissue develops. And think about all the muscles in your body. Your tongue is a muscle. They lose strength in their tongue, the muscles around their lungs, around their heart, and eventually, you know, because their heart is a muscle that they die of cardiac failure.”    “And we always say, "The kids know something's going on. They may not have the language for what's happening, but you've got to give them the tools and the knowledge to function. And it's not your disease. It's their disease." So they need information for their disease.”   “And so that first week was terrible. But the week after, we looked at each other and I said, "I think we're supposed to be in this, I think we have purpose to fight this disease." And my husband agreed. You know, we sat down probably two weeks after Joel was diagnosed. We went out to dinner and we said, "What are our new priorities? What do we want to do?" And so we made just a list of, these were our priorities for our family, and it's priorities that actually guide our family even to this day.”   “And she was having these very strange symptoms, just high fever, throwing up. Her lymph nodes were so enlarged, you couldn't even see her neck. She... wherever she had a scratch, it had like blown up, just swelled. Just a little tiny scratch, had like blown up. And so we got to the hospital and spent a long time there. And they did a lot of tests. And it was really weird.”   “And something in that moment helped me just gain a newfound strength, and a feeling that I can fight for my children, I can fight for other children, and I can be this advocate for them. And that was so empowering for me, to realize, you know, I think we all need to get to that place where we can be empowered to be the strength for the people that we love.”    “And that is true for a special needs family. Your fight-or-flight is always up. And I don't know, we've just tried to not let that dictate our entire lives, to try to stop and have fun, and, you know, have humor about the situation.”   “I think it's just permission-giving for each person, and for your special needs child that's grieving. You know, they're grieving losses along with you.”   “So I'm just trying to find where I'm being offered grace and hope and unexpected things that for me are miracles.” TRANSCRIPT AVAILABLE https://inourbelly.com/season-2/rachel-poysky   GUEST RESOURCES "Help Tackle" Duchenne Muscular Dystrophy: http://CoachtoCureMD.org Check out #coach2curemd hashtag on Instagram https://www.instagram.com/explore/tags/coachtocuremd/ Dr. James Poysky https://www.katychildpsychology.com/OurProviders.en.html RESOURCES Underbelly Workshops: Connect the dots, master your story http://inourbelly.com/underbelly  Bringing to life the wisdom in your transformation journey through a clear and compelling story is essential to building a conscious business. Whether you are meeting a potential customer for your coaching or healing practice, recruiting talent for your growing business, or sharing your message with a larger audience, your personal transformation story is your greatest asset. We guide you back to this experience, helping you connect the dots in the transformation pattern, and master your story.  Beyond the Belly: A podcast about the healing patterns of transformation http://inourbelly.com/beyond Our newest podcast, Beyond the Belly, unpacks wisdom in the patterns of transformation. Expert friends of mine join to discuss topics coming across all of the stories in Belly of the Beast Life Stories. Belly of the Beast Life Stories http://inourbelly.com   @inourbelly on Instagram http://instagram.com/inourbelly   Facebook Community http://facebook.com/inourbelly   @davidall (host) http://instagram.com/davidall - END -

Rich Horgan is the Founder and President of Cure Rare Disease. Rich is also a Blavatnik Fellow at Harvard Business School with a deep passion for Duchenne muscular dystrophy (DMD) and other rare diseases. With a younger brother impacted by the disease, Rich has a strong interest in accelerating promising treatments for the disease. He formed a collaboration with world-class researchers and clinicians to pioneer the development of customized therapies for Duchenne and other rare diseases. He also launched a company, Myofinity Biosciences, to focus on the commercialization of effective therapies for DMD and is working in collaboration with leading scientists in the field. Prior to making his foray into biotech, Rich had extensive experience working in new business development at Corning Incorporated where he led the successful launch of a new Willow® Glass product. He also launched a successful car washing business in upstate New York. He holds a BS from Cornell University where he graduated as summa cum laude and an MBA from Harvard Business School.We encourage you to donate using this link: https://cureraredisease.org/support-us/one-time-donation/

In this podcast we speak with Prof Volker Straub about Testosterone, which is sometimes given to patients with Duchenne Muscular Dystrophy (DMD) who take steroids. Steroids are part of the recognised standard of care in treating Duchenne Muscular Dystrophy (DMD). But long-term use of steroids causes a number of side effects including delayed puberty. Testosterone is sometimes given to make boys begin going through puberty. There is a clinical trial running at the John Walton Muscular Dystrophy Research Centre (JWMDRC), led by Prof Volker Straub and Dr Claire Wood, treating 15 adolescents with DMD with testosterone to induce puberty. As well as looking at the effect of testosterone on pubertal development, growth, muscle strength and function, bone mineral density and body composition, the trial is looking at the mood, quality of life and well-being of patients to assess their satisfaction with the benefits of the treatment compared to the side effects. Duchenne UK has granted £228,562.51 to pay for the extension study of this trial to look at the longer term effects of testosterone treatment following earlier treatment to induce puberty. The extension study will investigate whether testosterone treatment to induce puberty will be enough to support long term testosterone production, or whether further treatment with testosterone is needed for patients on long-term steroids to keep producing testosterone, even if puberty was successfully induced.

In this weeks episode of Duchenne UK's DECODING DUCHENNE podcast series, our host Clare Runacres speaks to Emily Crossley, Fleur Chandler and Josie Godfrey about Project HERCULES. ​​Project HERCULES is a collaborative global project set up by Duchenne UK to increase the chances of patients with Duchenne Muscular Dystrophy (DMD) of accessing innovative treatments. It brings together pharmaceutical companies to develop and build a better evidence base to help support their case for the pricing and reimbursement of new treatments for DMD

In the first of our podcast series, our host Clare Runacres talks to Emily Crossley and Alex Johnson about why they co-founded the charity - Duchenne UK. They discuss their sons DMD diagnosis and the work the charity is doing to find treatments for Duchenne muscular dystrophy. Duchenne UK is a highly focused, ambitious and lean charity with a clear vision: to fund and accelerate treatments and a cure for Duchenne Muscular Dystrophy. Duchenne Muscular Dystrophy (DMD) is a devastating muscle wasting disease and is the most common genetic killer of children worldwide. There is no treatment or cure. Children will be totally paralysed by their teens and won’t live beyond their 20s...But thanks to recent breakthroughs, we believe we can save them.

Fundraising is a fantastic way of achieving remarkable life goals with the warm knowledge of giving back to charities and those in need. It is also a powerful way to help companies build employee and company engagement. Emma Hallam is Founder of charity Alex's Wish conquering Duchenne Muscular Dystrophy (DMD) – an aggressive life-limiting muscle wasting condition that affects 1 in 3,500 boys born across the world. Emma's passion to set-up a charity, came about when her 3-year old was diagnosed with DMD back in 2010. Emma has 26 years' experience in marketing, events and branding for big corporates including Experian, Alliance & Leicester and Mortgage Ad-vice Bureau at senior level. Join us as we discuss the important job Alex's Wish does, and how fundraising can help you achieve remarkable life changing goals and yield incredible results for your company!

Fundraising is a fantastic way of achieving remarkable life goals with the warm knowledge of giving back to charities and those in need. It is also a powerful way to help companies build employee and company engagement. Emma Hallam is Founder of charity Alex's Wish conquering Duchenne Muscular Dystrophy (DMD) – an aggressive life-limiting muscle wasting condition that affects 1 in 3,500 boys born across the world. Emma's passion to set-up a charity, came about when her 3-year old was diagnosed with DMD back in 2010. Emma has 26 years' experience in marketing, events and branding for big corporates including Experian, Alliance & Leicester and Mortgage Ad-vice Bureau at senior level. Join us as we discuss the important job Alex's Wish does, and how fundraising can help you achieve remarkable life changing goals and yield incredible results for your company!

When two of Jenn’s children were diagnosed with Duchenne Muscular Dystrophy (DMD), it changed her life. Since then, she’s fought for access to clinical trials and new treatments and inspired others to join the cause along the way.

Go like and follow Michelle and Summit Multisport on Facebook and on Instagram to stay up with the latest! To book your body composition or lactate threshold test go to the Summit Multisport website, let them know heard about it here!If you'd like to learn more about Duchenne Muscular Dystrophy (DMD) and support the cause you heard Michelle talk about, visit LittleHerculesFoundation.orgIf you'd like to read more in depth about this topic, or see the chart Michelle referenced check out this very in depth paper by Leonard A. Kaminsky, PhD; Ross Arena, PhD; and Jonathan Myers, PhD

This week on “Marriage to the Max”, we bring you a rich marriage conversation with our good friends, James and Rachel Poysky. James earned an MA in Psychology, an MA in Christian Leadership, and a PhD in Clinical Psychology from the Graduate School of Psychology at Fuller Theological Seminary. James is a Parent Project Muscular Dystrophy board member and Clinical Assistant Professor at Baylor College of Medicine and is in private practice. Rachel is an ordained pastor and earned her Masters degree in Divinity from Fuller Theological Seminary. She currently serves at Memorial Drive Presbyterian Church in Houston as Children's Ministries Director. The Poyskys have two beautiful children, Joel and Hallie. In November 2005, Joel was diagnosed with Duchenne Muscular Dystrophy (DMD). Since their family received this diagnosis, the Poyskys have been on the frontlines of the fight against Muscular Dystrophy and have helped and encourage people literally around the world. In this podcast episode, they shared solid insights with us about marriage health. We knew that this conversation would benefit not only married couples with special needs children, but also all married couples. You may now subscribe to “Marriage to the Max” on iTunes for free. Thank you so much for listening and for being students of healthy marriages!

Click to Subscribe to All Ben's Fitness & Get A Free Surprise Gift from Ben. Click here for the full written transcript of this podcast episode In this free November 3, 2009 audio episode, I interview Dr. Roby Mitchell about the swine flu, and answer multiple listener questions about Ice Baths, Carbonated Water, Anorexia, Triathlons, Muscle Spasms and much more! Featured Topic: Dr. Roby Mitchell consults world wide with  physicians interested in transitioning their patients onto regimens that take them off drugs and on to healthful regimens using nutrition, exercise, bio-identical hormone replacement, and targeted supplements. and takes a very unique stand on the swine flu "epidemic".  In our interview, Dr. Mitchell includes the following topics: -Who needs to be vaccinated against the swine flu, and why... -The potential dangers of vaccination if you don't actually need it... -The exact supplements you should be taking to protect yourself from the swine flu... -How to protect your body before you get on planes, trains and the subway...(including "Oil of Oregano") -What you should do about your children and the swine flu... -How hormone and steroid levels drastically affect your potential immunity to the swine flu... -And much, much more! Be sure to check out Dr. Mitchell's website by clicking here. Listener Q&A: Listener Patrick  asks: "I'd be interested in knowing the latest info on ice baths: - Are they helpful or full of hype? - What's the ideal temperature range and immersion time? - Should it be done before or after a warm post-workout shower? - What to do about the grunts/screams/explicatives on initial immersion?" Listener Mark asks: "In an effort to give up soda, i have started to drink carbonated water (Wegmans brand) which is naturally flavored.  I drink roughly 36 ounces per day.  Are there any health risks associated with drinking carbonated water?  I have recently heard that the carbonation depletes your body of calcium....is this true?" Listener Chantelle asks: "I don't know if you have ever addressed this one before, but one of my near and dear friends is addicted to laxatives and then exercises almost to the point of anorexia. But she doesn't know how to get off the laxatives because then she becomes constipated and that, of course, makes her feel fat. She eats a lot of high fiber foods, but even just a bit of salt or bread makes her constipated. Would this be something that you would ever address as far as what she should eat, how to quit, etc?" Listener David asks: "I started listening to your podcasts and really enjoy the informative topics and am slowly making my way through the archived podcasts. Great stuff by the way.   I am a triathlete with 3 IMs under my belt, and as we enter the off-season I am presented with a fork in the road decision.  Last off-season I subscribed to a training regimen counter to the conventional mainstream in which a training season begins training one's base and performing long, slow distance workouts at relative mild intensities. Last year my off-season consisted of short duration (hour or less), small volume, but high intensity bike and run workouts to build pure speed.  I got significantly faster by several minutes in 10K runs and increased my functional threshold power (watts) on the bike by about 15% during the off-season time. Then as the real training season began, volume and longer duration workouts were put on top of the new speed --- in other words… speed first then build distance on top of that speed.  This was quite successful for me last year as I had several breakthrough performances and PRs in several olympic and half-iron distance triathlons.  This training philosophy is almost opposite the mainstream ---- build base (ie. long distance, mild intensity), then race specific speed as one nears a race event. My fork decision currently is the two training philosophies above.  Many friends insist my prior year speed first approach is crazy, a crash-n-burn approach and adhere to the mainstream approach and that I was just lucky last year.  I am curious on your opinion on these two different training approaches, and possibly if other approaches may also be worth considering as a new off-season and soon to be training season begins?  Thank you." Listener Eric asks: "I have a few swimming questions that I would like to hear you answer. 1. I am training for open water triathlons where I wear a wet suit but swimming in the pool without one.  I have heard some people say that I should use a pull buoy when I train to simulate the wetsuit buoyancy but read an article that says stay away from toys.  Does the pull buoy help and if so, what frequency should it be used when training? 2. Swimming is something that I never really did until about a year ago when I decided to start doing triathlons.  One thing that I never learned how to do when I was growing up was the flip turn or any other turn method for that matter.  When I reach the wall at the other end, I usually stand up for a second or two and turn around.   I'm sure that is probably cheating, but should I spend time learning to do some other type of turn when my competition will be open water, which has no turns? 3. I read the article that says to use no toys, but I travel alot and many of my swim training days are either replaced with extra runs or done in  a hotel pool while I am on the road.  I saw a bun-gee cord that you can strap to your legs and swim in place, which is ideal since most hotel pools are not big enough to get a good workout in.  My question is are there negative side effects to something like this or is that a good investment for when I travel?" Listener John asks: "How can someone train for am ironman for 8 months and cross the finish line with saddle bags. I mean, all that endurance training, and the body responds with smooth no definition. I can;t figure out if it is diet, not enough weight training, or to much endurance training, that does not allow the body to get cut up and muscluar, not like a body builder, but like maybe a cross between a bodybuilder and an athlete." Listener Eric asks: "I took many of your supplements last year and will continue to do so this race season.  In putting together my supplement plan I have a question. 1) On the Enerprime Superfood Multi-Vitamin what is better to have or use?  The powder or capsule? or is it better alternate both for different uses - powder to mix w/ drinks and smoothies?  Would there be a need to take in more than the recommended dosage of 6 capsules? 2) Is there any benefit to the auto-ship, i.e. no back order delays, and/or continued discounts. 3) Have you ever given it any thought to do a podcast on electric stimulation devices.  Are they actually good for recovery, strength training, Pros & Cons, and any side effects. 4) I'm looking for new ways to help offset some of the costs of this sport.  This past year I helped bring in a few sponsors to a new bike club that started in our area.  The money from the sponsors, and memberships was to help offset the cost for race fees, and Tri/Cycling gear.  The ring-leader had a scattered brain approach, and mismanaged the money so the only thing we benefited from was a small discount on some high end LG gear. This year I'm looking to possibly break off on my own for sponsorships, and maybe expanding it to products that I actively use during a race and training.  I'm no pro, but can the average Joe get GU for example to sponsor/donate/discount their products? My training partner (who qualified for KONA this year) and I have been asked to race for a local charity team to help bring awareness and raise money for Duchenne Muscular Dystrophy (DMD).  Maybe it would be easier to bring in sponsors this route?  What are your thoughts? If you don't mind, at your convenience maybe we could discuss your experiences? or give any advise?" Listener Erin asks: "Hi Ben, I have been reading you e-health handbook.  Thank you for all the helpful information! I have a question for you that has no easy answer, but I thought it worth giving it a try. Whenever I participate in an excercise program, my trapezius muscles seize.  I have trigger points that react the second there is any stress on the area.  I have slight scoliosis at the base of the neck which forces my head slightly forward. I avoid any exercises that might aggravate them, but I still end up in pain that ends up in a migraine from the compression on the base of my skull.  I have been to the doctor, the osteopath, the physio, and trainers, but other than new stretches, which I do religiously, it has not helped.  I am trying to work on my core muscles to support them, but even doing those I have to be very careful. I know some people suggest exercising the muscles themselves to increase blood flow, but that would cause them to seize so quickly that I would be nauseous within minutes. I need to find a way to exercise that won't end up with me incapacitated from pain.  Even cardio using the arms can do it.  I do what yoga stretches I can to support my posture. Is there any way to really isolate those muscles during a work out to avoid using them?  I am already very careful with my head and don't do anything that may stress the neck. Anything could be helpful, thanks in advance." Do you have a question? Remember, you can now ask your questions via *audio* to me via the free Skype software by simply “Skyping” me at username “pacificfit“. You can also call toll free to 1-877-209-9439 and leave a voicemail for Ben Greenfield. ----------------------------------------------------------- Special Announcements: 1) Ben Greenfield now has a pre-written holistic Ironman nutrition plan that is specifically designed for TrainingPeaks. Whether you have no clue what TrainingPeaks is or you already have a TrainingPeaks account and want to import the meal plan to your training calendar, you can check everything out by clicking here. 2) The new BenGreenfieldFitness cycling shorts and jerseys were released this week to a select group of triathletes and cyclists! If you are interested in getting in on the next order, which will be triathlon shorts with a triathlon top (pictured at right) simply e-mail ben@bengreenfieldfitness.com to be added to the next order, which will be placed by November 15. Here's what some athletes have had to say so far: Stephen says: "These Kits are sweet!  Comfortable, light weight with and the shorts have high quality pad.  Out of all my gear these kits are by far the most comfortable." Scott says: "Ben, Just got my Pacific Elite Fitness cycling jersey and shorts. Let me just say, I am an extremely picky shopper when it comes to cycling gear. Out of all the dozens of jerseys and shorts sitting in my closet, I have a new favorite that I will undoubtedly wear every time I go riding. It is true to its size, fits greats and is the most comfortable jersey I own. Plus, it looks awesome! Thanks again!" Ken says: Hi Ben,  Thanks for the cycling jerseys and shorts.  Very cool!  All we need now is a full tri-kit with arm, leg warmers,hat, vest, jacket and tri-suit!  Thanks! httpv://www.youtube.com/watch?v=Kwt136vOhRU 3) Ben Greenfield is just 6 weeks into his supplementation with Bioletics, based on the interviews about the six key performance factors in podcasts #53 and #62 (which you can find by clicking here). If you're ready to get started, just click here to go to the Bioletics website to begin your six key performance factor testing. 4) The Triathlon Dominator Package is officially live and available with exclusive web-only pricing. You can learn more about exactly how to successfully train for Ironman without neglecting your family, career, hobbies and social life by clicking here, or by clicking on the video below: httpv://www.youtube.com/watch?v=GmUSi7b2cNY 5)Click here to get the full scoop on the brand new Pacific Elite Fitness Triathlon Training Camp in Austin, Texas - including registration details, itinerary, food, training, activities and much more! This is a once-in-a-lifetime opportunity to get a fantastic deal on a camp because the Endurance Ranch in Austin has just opened and is offering Pacific Elite Fitness special promotional pricing. Click on the logo below to learn more, or simply e-mail ben@bengreenfieldfitness.comto add your name to the list. 6) And finally...the bonus video - Ben Greenfield's Jamaican Triathlon Adventures! httpv://www.youtube.com/watch?v=XRI8fhU3BnY ----------------------------------------------------------- That's all for this week! Remember, if you have any trouble listening, downloading, or transferring to your mp3 player just e-mail ben@bengreenfieldfitness.com. And don't forget to leave the podcast a ranking in iTunes - it only takes 2 minutes of your time and helps grow our healthy community! Just click here to go to our iTunes page and leave feedback. Upcoming episodes include expert interviews on Hormone Fluctuations in Male & Female Athletes, and Optimizing Biomechanical Movement Patterns During Exercise. Finally, remember all the time put into producing this podcast for you, and consider donating to our show, we'll throw in a free T-shirt or your choice of any of the BenGreenfieldFitness active singlets, hoodies and hat pictured below and available in our new store.