Podcasts about using crispr

What if we could delay the age of menopause? Staša Stanković, PhD is a geneticist and bioinformatician with a PhD in Reproductive Genomics from the University of Cambridge. She focuses on deciphering genetic architecture of reproductive ageing and fertility, and their link to health outcomes in women. This work led to the discovery of genetic signals that influence the age women begin menopause and the first evidence of the ability to, through gene manipulation, extend reproductive lifespan and improve fertility in mice, thus paving the path towards first genetic test for the prediction of menopause time and next-generation therapeutics for ovary-centric disorders in humans.(00:00) Stasa's early experiences with womanhood(03:32) Intro to genomics in women's health(05:33) Historical neglect in women's health research(07:51) Delaying motherhood vs. female biology(09:39) Redefining menopause as "reproductive ageing"(13:54) The difference between reproductive ageing in men v. women(14:39) Menopausal timing variation and early menopause(16:54) How the age of menopause can help fertility planning(19:30) How reproductive age relates to our longevity and health(23:02) Epigenetic factors that influence menopause timing(24:49) Mother's diet during pregnancy can influence the menopause timing of the baby(26:46) How genomic medicine is revolutionizing reproductive ageing(30:08) Insights from DNA analysis of 200,000 women(39:45) How ancestry can influence menopausal timing(42:52) Can we delay menopause today?(46:15) Using CRISPR technology to delay menopause in mice(48:49) The goal of delaying menopause(59:23) Why should we "mess" with our biology?Links:Staša's Linkedin - https://www.linkedin.com/in/stasa-stankovic-93723a137 Hosted on Acast. See acast.com/privacy for more information.

Lords: * Megan * Lexi Topics: * Erik Satie's performance indications * https://www.ilxor.com/ILX/ThreadSelectedControllerServlet?boardid=60&threadid=4497 * Instant food from other cultures (why isn't everyone eating maggi noodles??) * Seasonal decorations * Delhi Metro * https://docs.google.com/document/d/17k75ftxEn2xR-tJkLSV4H8st5BFAxPNxE3BNCXDI6Go/edit * Becoming Immortal by being predictable * Living in different climates (e.g. my experiences with the harsh winters of Chicago vs sweltering Austin TX summers) Microtopics: * Music implementation for The Lamplighters League. * Watching a streamer play games and asking them for a turn at the controls. * How to pronounce "Erik Satie." * How to pronounce "Gymnopedies." * Finding 100 umbrellas in your dead friend's apartment. * A list of Satie's performance indications. * Grandly forgetting the present. * With your bones dry and distant. * Playing music with your forehead. * Doing something to a piano. * Your boss sending a memo asking you to work with a shy piety. * Pizzicato vs. Bartok pizzicato. * Adding the hamburger so it's not just Helper. * What instant foods are missing from your food vocabulary. * Adding heavy cream to ramen broth. * Getting an apron so you can have a little costume when you cook. * Realizing that when you wear the apron you don't get food on your shirt. * A big bib for Big Jim. * Normalizing scoop bibs. * Kraft Dinner. * Halal certified instant stir fry noodles. * Ramen in a cup or ramen where you provide your own container. * Insurance Mac. * Canned cheeseburgers. * A boring house with nothing on it. * Movable feasts. * Keeping those 12-foot skeletons in your yard and decorating it seasonally. * The beetles that clean bones for you. * Recreational Explosives Day. * A Zachtronics programming puzzle for every holiday. * A movable feast where you don't eat. * Decorating your house to celebrate Toyotathon. * Falling for strangers and their blue hair. * A poem that is long if you read it but short if you recite it. * Taking public transit as an act of defiance. * A gift that is impossible to give yourself on purpose. * Inventing a shower proof phone so nobody ever has shower thoughts again. * Putting your phone in a Ziploc bag and watching movies underwater. * Sitting down at your computer and getting stuck. * Hacking your executive function by adding friction in the right places. * Whether Wellbutrin gives everyone tinnitus or just you. * Death hacks for staying mentally connected to your dead relatives. * A service that puts your podcast on vinyl. * Using CRISPR to infect the cockroach population with 229 episodes of Topic Lords. * Moving to a land where your snot doesn't freeze. * Not trusting your own weather opinions. * Surprising yourself by enjoying seasons. * Driving in icy conditions. * Standing under the heated lamps like a lizard. * Waiting for the bus in the dark. * Learning to drive after you move to a city with public transit. * Not driving with kids. * Getting rid of all the bots. * Sgt. Pepper Bot.

Travis Hardcastle and Seth Hanson answer questions from a webinar where they discuss innovative applications of CRISPR and iPSCs in disease modeling and drug discovery.

Forrest Galante is a 6X world record spear fisherman, wildlife biologist, conservationist & explorer. He hosts 'Extinct or Alive' on Animal Planet, and 'Mysterious Creatures' on Discovery Channel. EPISODE LINKS: https://youtube.com/@ForrestGalante https://instagram.com/forrest.galante SPONSORS: https://magicmind.com/danny - Use code DANNY for up to 56% off your subscription. https://ghostbed.com/danny - Use code DANNY for 40% off. https://ver.so/danny - Use code DANNY to save 15% on your order. FOLLOW DANNY JONES https://www.instagram.com/jonesdanny https://twitter.com/jonesdanny JOIN ON PATREON: https://bit.ly/koncretepatreon OUTLINE: 00:00 - Discovering ancient fossils Florida 02:18 - Spearfishing & sharks 13:23 - Forrest reacts to Egypt Shark Attack Video 14:32 - Footage of Forrest getting struck by lightning 18:22 - What sharks actually eat people? 20:48 - Shark population in the US 30:45 - Growing up in Zimbabwe Africa 40:20 - The active unregulated WAR happening in south Africa 49:00 - Paul Rosolie & the Amazon rainforest 54:46 - Uncontacted tribes 01:01:28 - Origins of the Amazon & Graham Hancock's theory it was man made 01:06:56 - Using CRISPR to bing back the Wooley Mammoth 01:17:30 - The Colombian Amazon 01:20:59 - The Galapagos 01:29:24 - Swimming with Orcas 01:37:06 - Ric O'barry (The Cove) 01:45:07 - Crocodile massacre of Mayanmar 01:51:17 - Largest cave on the planet: Son Doong cave 01:58:42 - Undiscovered Species and Crazy Encounters 02:05:23 - Misconception on sharks 02:15:15 - Mushroom hunting 02:18:55 - Chameleon ranching

Interview with Dan Friesen and Jordan Holmes from the Knowledge Fight podcast; Quickie with Bob: Solar Panels at Proxima Centauri; News Items: Oldest Evidence of Humans in Americas, Addictive Foods, Using CRISPR to Make Chickens Flu Resistant, Superheavy Elements, Prehistoric Solar Storms; Who's That Noisy; Your Questions and E-mails: Nobel Peace Prize; Science or Fiction

Interview with Dan Friesen and Jordan Holmes from the Knowledge Fight podcast; Quickie with Bob: Solar Panels at Proxima Centauri; News Items: Oldest Evidence of Humans in Americas, Addictive Foods, Using CRISPR to Make Chickens Flu Resistant, Superheavy Elements, Prehistoric Solar Storms; Who's That Noisy; Your Questions and E-mails: Nobel Peace Prize; Science or Fiction

In this episode:00:46 Engineered pig kidneys show transplantation promiseKidneys from genetically-engineered miniature pigs have been transplanted into non-human primates, in some cases keeping the animals alive for more than a year. Using CRISPR, a team made dozens of edits to the pig genome to prevent the monkeys' immune system from attacking the organs. They also removed pig retrovirus genes that could represent an infection risk. These steps are necessary if pig organs are to be used in human transplants, something many clinicians and researchers think will be needed to overcome a critical shortage of organs for transplantation.Research article: Anand et al.News and Views: Pig-to-primate organ transplants require genetic modifications of donorNature News: The most-complex gene edits yet move pig organs closer to human transplant09:02 Research HighlightsHow babies' nasal immune systems could explain why they tend to have mild cases of COVID-19, and the molecular ‘glue' that allows 3D printing with challenging materials.Research Highlight: How the littlest children stop SARS-CoV-2 in its tracksResearch Highlight: 3D printing tackles tricky materials with help from tiny crystals11:35 Briefing ChatThis time, the discovery that the human brain uses one system for estimating whether a group contains four or fewer items, and a different one for when there are five or more. Plus, we discuss how researchers fixed the Euclid telescope's wobbles.Nature News: Your brain finds it easy to size up four objects but not five — here's whyNature News: ‘Immense relief': Universe-mapping Euclid telescope fixes problem that threatened missionSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.12.548706v1?rss=1 Authors: Wu, Y., Ding, C., Weinreb, A., Manning, L., Swaim, G., Yogev, S., Colon-Ramos, D., Hammarlund, M. Abstract: Mitochondria transport is crucial for mitochondria distribution in axons and is mediated by kinesin-1-based anterograde and dynein-based retrograde motor complexes. While Miro and Milton/TRAK were identified as key adaptors between mitochondria and kinesin-1, recent studies suggest the presence of additional mechanisms. In C. elegans, ric-7 is the only single gene described so far, other than kinesin-1, that is absolutely required for axonal mitochondria localization. Using CRISPR engineering in C. elegans, we find that Miro is important but is not essential for anterograde traffic, whereas it is required for retrograde traffic. Both the endogenous RIC-7 and kinesin-1 act at the leading end to transport mitochondria anterogradely. RIC-7 recruitment to mitochondria requires its N-terminal domain and partially relies on MIRO-1, whereas RIC-7 accumulation at the leading end depends on its disordered region, kinesin-1 and metaxin2. We conclude that polarized transport complexes containing kinesin-1 and RIC-7 form at the leading edge of mitochondria, and that these complexes are required for anterograde axonal transport. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

According to scientists, 30,000 species per year are being driven towards extinction and 50% of all species could be extinct by 2050 due to climate change. But what if there was something we could do, in addition to conservation, to change this trajectory? That's what the scientists and engineers at Colossal Biosciences are working towards: reversing extinction. Using CRISPR and advanced gene editing techniques, they plan to bring back the woolly mammoth and the dodo bird to help combat climate change and complement existing conservation efforts. Join us to discuss this topic with Ben Lamm (Colossal Biosciences); Tom Chi (At One Ventures); and John Calvelli (Wildlife Conservation Society).

How do you build a better burger? At SciFi Foods, they do it in the laboratory, using cutting-edge biology and bioengineering technology, like CRISPR, to cultivate beef cells, then add them to plant-based ingredients. On this episode of Tech Bites, host Jennifer Leuzzi talks with Dr. Kasia Gora, PhD, co-founder ,and CTO of SCiFi Foods about the race to be first to market in cultivated beef with the launch of the SCiFi burger.Photo Courtesy of Jen Garcia.Heritage Radio Network is a listener supported nonprofit podcast network. Support Tech Bites by becoming a member!Tech Bites is Powered by Simplecast.

The new strain of rice could help farmers save labour and water resources while combating weed infestations. You can read the story at: https://botany.one/2023/03/study-develops-herbicide-resistant-super-basmati-rice-using-crispr-cas9/ You can read the original research at https://academic.oup.com/aobpla/article/15/2/plac059/6986705

We're back this week with Seth Shipman from the Gladstone Institutes and the University of California, San Francisco. Seth has built molecular recording devices that can record data within living cells. He even used these methods to re-create one of the first movies put to film. This work has clear technological implications and is also providing insights into phage biology.

An experiment tests whether the gene-editing technology can stop the virus from replicating, which would ultimately wipe out the infection.

An experiment tests whether the gene-editing technology can stop the virus from replicating, which would ultimately wipe out the infection.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.19.508525v1?rss=1 Authors: Choi, E. Y., Franco, D., Stapf, C. A., Gordin, M., Chow, A., Cover, K. K., Chandra, R., Lobo, M. K. Abstract: Substance use disorder is a debilitating chronic disease and a leading cause of disability around the world. The nucleus accumbens (NAc) is a major brain hub that mediates reward behavior. Studies demonstrate exposure to cocaine is associated with molecular and functional imbalance in two NAc medium spiny neuron subtypes (MSNs), dopamine receptor 1 and 2 enriched D1-MSNs and D2-MSNs. Our previous reports showed that repeated cocaine exposure induced transcription factor early growth response 3 (Egr3) mRNA in NAc D1-MSNs, while reducing it in D2-MSNs. Here, we report our findings of repeated cocaine exposure inducing cell subtype specific bidirectional expression of the Egr3 corepressor NGFI-A-binding protein 2 (Nab2). Using CRISPR activation and interference (CRISPRa and CRISPRi) tools combined with Nab2 or Egr3 targeted sgRNAs, we mimicked these bidirectional changes in Neuro2a cells. Furthermore, we investigated D1-MSN and D2-MSN subtype specific expressional changes of histone lysine demethylases Kdm1a, Kdm6a and Kdm5c in NAc after repeated cocaine exposure. Since Kdm1a showed bidirectional expression patterns in D1-MSNs and D2-MSNs, like Egr3, we developed a light inducible Opto-CRISPR-KDM1a system. We were able to downregulate Egr3 and Nab2 transcripts and cause bidirectional expression changes in D1-MSNs and D2-MSNs similar to cocaine exposure in Neuro2A cells. In contrast, our Opto-CRISPR-p300 activation system induced the Egr3 and Nab2 transcripts and caused bidirectional transcription regulations in D1-MSNs and D2-MSNs. Our study sheds light on the expression patterns of Nab2 and Egr3 in specific NAc MSN subtypes in cocaine action and uses CRISPR tools to further mimic these expression patterns. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

A topic of science fiction not even a decade ago, genome editing technologies are now being used to research breeding efficiency and bacterial resilience in soybean. Get down to the molecular level in this episode of I See Dead Plants with Host Ed Zaworski and Iowa State University plant virology specialist Dr. Steve Witham as they discuss the CRISPR/Cas9 system and its implications for the future of crop disease management research.  Article discussed: “CRISPR/Cas9-Based Gene Editing Using Egg Cell-Specific Promoters in Arabidopsis and Soybean”. How to cite the podcast Zaworski, E. (Host) and Witham, Steve (Interviewee). Refried Genes: Using CRISPR/Cas9 Systems to Edit the Genome of Soybeans S1:E14 (Podcast). 05-18-22. In I See Dead Plants. Crop Protection Network. www.cropprotectionnetwork.org    

Today on the Naturally Inspired Daily Clip Tammy Talks About: Leo Hohmann's new article on CRISPR.  

Joining Cade in the lab this week is Dr. Peter Bircham to discuss the work his team has done on using CRISPR to edit yeast genes. The Brü Lab is brought to you by Imperial Yeast who provide brewers with the most viable and fresh yeast on the market. Learn more about what Imperial Yeast has to offer at ImperialYeast.com today. | Read More | Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts

UC Consortium launches first clinical trial using CRISPR to correct the gene defect that causes Sickle Cell Disease. Dr. Mark Walters of UCSF talks about a new CRISPR gene therapy developed by scientists and physicians at UC Berkeley, UCSF and UCLA. The trial aims to directly correct the sickle mutation in blood stem cells that causes them to create deformed red blood cells, leading to the debilitating and painful disease. It will be the first time clinical researchers attempt to correct the faulty beta-globin gene in a patient's own cells with non-virally delivered CRISPR gene correction tools. Series: "UC Berkeley News" [Health and Medicine] [Show ID: 37368]

UC Consortium launches first clinical trial using CRISPR to correct the gene defect that causes Sickle Cell Disease. Dr. Mark Walters of UCSF talks about a new CRISPR gene therapy developed by scientists and physicians at UC Berkeley, UCSF and UCLA. The trial aims to directly correct the sickle mutation in blood stem cells that causes them to create deformed red blood cells, leading to the debilitating and painful disease. It will be the first time clinical researchers attempt to correct the faulty beta-globin gene in a patient's own cells with non-virally delivered CRISPR gene correction tools. Series: "UC Berkeley News" [Health and Medicine] [Show ID: 37368]

UC Consortium Launches First Clinical Trial Using CRISPR to Correct Gene Defect That Causes Sickle Cell Disease Dr. Mark Walters of UCSF talks about how those who suffer from sickle cell disease, could be helped by a new CRISPR gene therapy developed by scientists and physicians at UC Berkeley, UCSF and UCLA. The trial aims to directly correct the sickle mutation in blood stem cells that causes them to create deformed red blood cells, leading to the debilitating and painful disease, according to Mark Walters, MD, a professor of pediatrics at UCSF and principal investigator of the clinical trial and gene editing project. It will be the first time clinical researchers attempt to correct the faulty beta-globin gene in a patient's own cells with non-virally delivered CRISPR gene correction tools. Series: "UC Berkeley News" [Health and Medicine] [Show ID: 37368]

UC Consortium launches first clinical trial using CRISPR to correct the gene defect that causes Sickle Cell Disease. Dr. Mark Walters of UCSF talks about a new CRISPR gene therapy developed by scientists and physicians at UC Berkeley, UCSF and UCLA. The trial aims to directly correct the sickle mutation in blood stem cells that causes them to create deformed red blood cells, leading to the debilitating and painful disease. It will be the first time clinical researchers attempt to correct the faulty beta-globin gene in a patient's own cells with non-virally delivered CRISPR gene correction tools. Series: "UC Berkeley News" [Health and Medicine] [Show ID: 37368]

UC Consortium launches first clinical trial using CRISPR to correct the gene defect that causes Sickle Cell Disease. Dr. Mark Walters of UCSF talks about a new CRISPR gene therapy developed by scientists and physicians at UC Berkeley, UCSF and UCLA. The trial aims to directly correct the sickle mutation in blood stem cells that causes them to create deformed red blood cells, leading to the debilitating and painful disease. It will be the first time clinical researchers attempt to correct the faulty beta-globin gene in a patient's own cells with non-virally delivered CRISPR gene correction tools. Series: "UC Berkeley News" [Health and Medicine] [Show ID: 37368]

In this CRISPR Cuts episode, Dr. Jesse Boehm, the Chief Scientific Officer of the Break Through Cancer Foundation and principal investigator at the Broad Institute, talks about his work on rare cancers. He also covers how CRISPR technology is transforming cancer research.

KSQD 6-23-2021: All about Omega 3 polyunsaturated fatty acid supplements; DHA helps kill cancer cells; Why pregnant women should get a Coronavirus vaccine; The many benefits of nitric oxide from cardiac health to immunity and reduced stroke risk; Interpreting low ferritin -- iron metabolism effects on inflammation and proper iron supplementation; The importance of Vitamin D, an immune system signaling hormone -- you get worse COVID-19 illness with low Vitamin D; New applications of CRISPR to affect epigenetic changes rather than direct DNA editing -- a safer strategy to treat genetic diseases; Poor gum microbiome increases amyloid in spinal fluid and raises risks for dementia

KSQD 6-23-2021: All about Omega 3 polyunsaturated fatty acid supplements; DHA helps kill cancer cells; Why pregnant women should get a Coronavirus vaccine; The many benefits of nitric oxide from cardiac health to immunity and reduced stroke risk; Interpreting low ferritin -- iron metabolism effects on inflammation and proper iron supplementation; The importance of Vitamin D, an immune system signaling hormone -- you get worse COVID-19 illness with low Vitamin D; New applications of CRISPR to affect epigenetic changes rather than direct DNA editing -- a safer strategy to treat genetic diseases; Poor gum microbiome increases amyloid in spinal fluid and raises risks for dementia

First, Gavriel's muscles got weaker. Then, he lost the ability to walk. From there, things will only get worse. The cause is Duchenne Muscular Dystrophy, a genetic disorder with no cure. But that might soon change. Using CRISPR, a state-of-the-art gene-editing tool, SickKids scientists were able to correct the disease-causing mutation in mice. The result? Improved muscle strength and function—and no signs of paralysis. Now, they're refining their approach, so they can take this treatment out of the lab and into the world.For more information on this episode, visit sickkidsfoundation.com/podcast/duchenne. And to fund research like this, go to sickkidsfoundation.com/donateSickKids Foundation is proud to recognize CIBC as the Premier Sponsor of the SickKids VS Podcast.

Did you know cassava can cause cyanide poisoning if it is not processed correctly and consumed with a protein-poor diet? In this episode, we chat with IGI researchers, Jess Lyons and Michael Gomez about their work on using CRISPR to reduce cyanide in cassava and improve its food safety.

The gene editing technology CRISPR-Cas9 is being harnessed to alter DNA, but Locanabio is using it to create a new class of genetic medicines that can precisely target and modify dysfunctional RNA. The company says that its approach will allow it to produce in vivo medicines that combine the specificity of RNA-binding proteins with the effect of a one-time gene therapy. We spoke to Jim Burns, CEO of Locanabio, about its platform technology, the benefits of using CRISPR to target disease-causing RNA, and why this approach could be applied to a broad range of genetic diseases.

Joe, Tim, and Ben talk about the long awaited Model Y 7-seater, SpaceX Starship SN9 triple static fire, and scientists using CRISPR to store binary data in DNA Read more from the articles we referenced: Model Y 5 Star Saftey - https://www.tesla.com/blog/model-y-achieves-5-star-overall-safety-rating-nhtsa Model Y Crash Videos - https://twitter.com/Tesla/status/1349572805122113540 Model Y 7 Seater - https://insideevs.com/features/465979/video-tesla-model-y-seven-seat-buying-advice/ SN9 does a triple header static fire! - https://youtu.be/swL4xrmmLCk Earth's Future - https://phys.org/news/2021-01-earth-future-outlook-worse-scientists.amp New Shepard launches their 14th New Shepard - https://www.youtube.com/watch?v=g9oTZu2HP8U #whydonttheyjust by @Metaphoriumino1 - https://twitter.com/Metaphoriumino1/status/1349774839368790019 Lebron gets a Hummer EV, maybe - https://www.yahoo.com/amphtml/lifestyle/bad-girl-watch-lebron-james-230000984.html CRISPR DNA data storage - https://www.newscientist.com/article/2264383-crispr-gene-editing-used-to-store-data-in-dna-inside-living-cells/ Insight loses MOLE - https://twitter.com/NASAInSight/status/1349760462854909957?s=20 https://mars.nasa.gov/insight/spacecraft/about-the-lander/ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/olfpod/message

Join the drunk grads as they discuss the Nobel Prize winners, Where traffic comes from, How people are allergic to the moon, and much more in this episode. We also got questions from @phonotactless, @Natural1Podcast, and @Brineshrimp2 on twitter. If you want to submit a question then DM us @Drunkenlyedu on all social media platforms. Listen Responsibly

We see this new ingredient appearing advertised and in products everywhere. On the billboards, in the new shops next to our favorite restaurant, on the counters at the barbershop and when we pick up our prescriptions at the pharmacy. C-B-D. It has to do with the ongoing revolution that’s happening around the country—around the world—regarding the deregulation of marijuana. But there’s another revolution that will change our consumption of cannabinoids. That of synthetic biology.

Rich Horgan, How A Nonprofit Pharma Company Is Using CRISPR To Cure Muscular Dystrophy Many of us face challenging medical diagnoses, and those with rare diseases often get the news without any treatment options. Rich Horgan's family has been fighting his brother's Duchenne Muscular Dystrophy (DMD) diagnosis for over two decades. Rich's relentless dedication to helping his brother Terry led him to leave Harvard Business School to create the first nonprofit drug company to use CRISPR to cure DMD. Rich shares his journey, the future of personalized gene therapy and how he built an organization to save not only his own brother, but other patients fighting these incurable diseases.

Rich Horgan, How A Nonprofit Pharma Company Is Using CRISPR To Cure Muscular Dystrophy Many of us face challenging medical diagnoses, and those with rare diseases often get the news without any treatment options. Rich Horgan’s family has been fighting his brother’s Duchenne Muscular Dystrophy (DMD) diagnosis for over two decades. Rich’s relentless dedication to helping his brother Terry led him to leave Harvard Business School to create the first nonprofit drug company to use CRISPR to cure DMD. Rich shares his journey, the future of personalized gene therapy and how he built an organization to save not only his own brother, but other patients fighting these incurable diseases. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app The post Rich Horgan: How A Nonprofit Pharma Company Is Using CRISPR To Cure Muscular Dystrophy appeared first on Momentum Magnet.

In this episode of a16z bio Journal Club, general partner Vijay Pande, bio deal team partner Andy Tran, and bio editor Lauren Richardson discuss a novel CRISPR-Cas-based anti-viral strategy.The discussion covers the differences between this newly developed prophylactic strategy, traditional vaccines, and anti-viral drugs; how this strategy can be engineered to target a huge range of coronavirus and influenza strains; and the next steps needed to go from paper to practice:“Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza” in Cell (April 2020), by Timothy Abbott, Girija Dhamdhere, Yanxia Liu, Xueqiu Lin, Laine Goudy, Leiping Zeng, Augustine Chemparathy, Stephen Chmura, Nicholas Heaton, Robert Debs, Tara Pande, Drew Endy, Marie La Russa, David Lewis, and Lei Qia16z Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology (for bio journal club). You can find all these episodes at a16z.com/journalclub.

Catherine Freije and Cameron Myhrvold are working on a test for the Covid-19 virus that will provide faster results than what's currently in use. They explain Why more prevalent and faster testing is vital in fighting the virus, How the development of a CRISPR-based diagnostic test, which primarily uses a nasal swab collection, can provide faster results—from an hour to a half hour, and The mechanics of how this test actually works with the CRISPR process, Cas13, and reporter signaling, and how the general process has worked with other viral infections. Cameron Myhrvold is a postdoctoral fellow in the Sabeti Lab and Catherine Freije is a Ph.D. student in Harvard University's Program in Virology and is also working in the Sabeti Lab. These two virologists discuss an exciting step forward in rapid testing for the Covid-19 virus that involves CRISPR. First, they discuss some general concerns of understanding how long the virus may linger and when exactly we can know when someone is contagion-free.  They explain that if we could test a lot of people more rapidly, it would be really helpful step forward. They tell listeners that their test is quantitative and can let you distinguish between infection levels that are really low or moderate versus high. They then explain the mechanics of the virus test: basically, they use a CRISPR process called Sherlock that picks a target with Cas13 and amplifies it for inspection through the cleaving process and reporter signaling.  They explain that this general process has been used for other viral infections like the Zika virus and Dengue, but must be specified for Covid-19. They add that they are still in the optimization phase, getting the test to work as well as possible. However, the turnaround for use will likely be accelerated by the FDA. They address other concerns about testing for the virus and challenges they may face. For more, see the lab website: https://www.sabetilab.org/

My guest today is D.A. Wallach, one of the more interesting investors I’ve come across. He is the former lead singer of the group Chester French and the former artist-in-residence at Spotify, where he was also an early investor. While he’s also an early investor in companies like SpaceX, his focus the last 5 years has been on early stage health care investing, which is the topic of this conversation. We discuss the entire life sciences and heath care investing ecosystem. This was recorded in the very early days of the Coronavirus outbreak so while we touch on it briefly it isn’t the primary focus, and I intend on returning to more traditional episodes like this one in the coming weeks, meant to be evergreen conversations. Please enjoy my conversation with D.A. Wallach. For more episodes go to InvestorFieldGuide.com/podcast. Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub. Follow Patrick on Twitter at @patrick_oshag   Show Notes 1:31 – (First question) – Where is interest in healthcare started 4:04 – How to categorize health services 5:13 – The product of medicine 6:56 – How medicine is changing in 2020 10:17 – What is enabling innovation in medicine 12:41 – Manufacturing of solutions, gene therapy example 17:16 – Using CRISPR 19:47 – Pros and cons, and the morality of gene intervention 23:44 – How progress is being made in medical breakthroughs 26:51 – What is the business and investment world seeing on the longevity side 30:15 – What is next in the wearable medical tracking trend 33:04 – The personalization of medical treatments 34:31 – How he thinks about all of this from an investing standpoint 36:37 – Exiting these companies 39:41 – How he thinks about founders in this space 42:35 – Drug prices             42:46 – The Paradox of Pricing 46:45 – What will lead to a change in the pricing of drugs 49:05 – The delivery side of healthcare 51:09 – Investments that could improve the delivery side of healthcare 53:33 – Thoughts on the anti-interventionist line of thinking in the medical world 57:50 – Lessons from his health portfolio 1:02:33 – Other frontiers that pique his interest, including gut biome 1:06:46 – His career in music 1:08:20 – Lessons he learned during his time in the music industry 1:10:19 – Opportunities in the music industry as an investor 1:12:29 – Kindest thing anyone has done for DA   Learn More For more episodes go to InvestorFieldGuide.com/podcast.  Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub Follow Patrick on Twitter at @patrick_oshag

This week on The People's Scientist podcast, I share with you an update on the first approved clinical trial using CRISPR gene editing in North America for cancer therapy. This clinical trial aims to recruit 18 patients living with cancer to test the safety and efficacy of CRISPR gene editing the patients' T-cells to seek out and kills their own cancer cells. Follow me on social media to see the papers I mention and for more scientific updates:IG: Dr.SCaligiuriFB: ThePeoplesScientistTwitter: DrSCaligiuriLinkedIn: Dr. Stephanie Caligiuri See acast.com/privacy for privacy and opt-out information.

As Basil continues to traverse on a distant timeline from our own, Gonz is joined by guest co-host Mel from Truthstream Media. They discuss Jeff Bezos’ new video of using his robot arms, a quick update on the scam that is the LIBRA project, and a Bloomberg article on how robots are decoding the cryptic language of central bankers! Go follow us on our new Twitch channel and stay tuned, as we will soon announce the date of our first live stream! And we know it’s not the best platform right now, but join us on Patreon to get MORE!   AGG for the WEEK of June 20th-June 26th YOU HEARD IT HERE FIRST, FOLKS! How to make money off Facebook’s Libra — Quartz    FLIPPY AND FAM! Robots Can Now Decode the Cryptic Language of Central Bankers - Bloomberg  Watch Jeff Bezos playing with giant remote-controlled robot hands - Business Insider  First-of-its-kind robotic arm works without brain implant  McDonalds Is Trialing Kitchen Robots And Voice-Automated Drive-Thrus  Toyota Basketball Bot Earns Guinness Record With 2,020 Perfect Throws | Digital Trends  Trash-Picking Robots? Park Bench Monitors? Toronto Debates Tech Giant’s Waterfront Plans    TECHNOLOGY, ROBOTS, AND AI! OH MY! This AI Uses Echolocation to Follow Your Every Move  AI services startup Hypergiant brings on Bill Nye as an advisor | TechCrunch  How Conversational Artificial Intelligence Is Providing Companionship To The Elderly  Artificial Intelligence Is Coming for Our Faces | WIRED  This terrifying AI generates fake articles from any news site  Thanks to AI, we know we can teleport qubits in the real | Cosmos  Artificial intelligence can't solve online extremism issue, experts tell House panel | TheHill  How Facebook's New 'Mirror World' Will Help Train AI  Bill Gates, Microsoft co-founder, says he'd start an AI company today  Hackers are turning our AI security systems against us — but they can be stopped  Can Space Robots Save Humanity?  MIT's new robot can identify things by sight and by touch  Wearable robot 'WalkON Suit' off to Cybathlon 2020  Self-Assembling Microrobots Can Be Programmed To Form A Tiny Car | Digital Trends  Bike and Snake: Meet the robots that will keep Norway's gas flowing  Robotic Vending Machines Want To Feed You Frozen Yogurt  Study: Social robots can benefit hospitalized children    BECAUSE SCIENCE! Physicists develop new method to prove quantum entanglement    CONSPIRACY THEORIES AND SOMETIMES FACTS! First clinical trail for male contraceptive gel starts in UK - Business Insider  Trump accidentally debunks his own “deep state” FBI conspiracy theory  - Vox  A brief history of the politics of UFOs - CNNPolitics  Moon landing 50th anniversary: why people like Steph Curry have supported conspiracy theories - Vox  UFO sighting: ‘Alien craft’ spotted during NASA Apollo 12 moon walk | Weird | News | Express.co.uk  Conspiracy Theorist Alex Jones Evades Crackdown On Social Media Sites  Arizona Board of Education backs off changes to sex ed curriculum amid uproar | Fox News  YouTube Star Etika Is Found Dead in NYC  Dementia risk tied to anticholinergic drugs in a new study - CNN  Smartphones aren’t making millennials grow horns. Here’s how to spot a bad study | PBS NewsHour  CLIMATE CHANGE AGENDA Here’s how AI can help fight climate change according to the field’s top thinkers - The Verge    SPACE/ALIENS/ETs/UFOs NASA Wants Robots to Sniff Out Moon Pits for Astronaut Homes | Space  Astronauts, not robots, essential to getting answers on the moon - UPI.com  Nasa Mars rover discovers gas that suggests recent alien life | The Independent  On Digital Mysticism  Mississippi town dedicates historical marker at site of 'alien abduction' | Fox News  Alien life on Mars may have emerged earlier than life on Earth, study says - CNET    BIOMEDICAL/GENETICS/TRANSHUMANISM Genetic Adam is 340,000 Years Old - Neatorama  Russia Will Genetically Test Soldiers To Identify The Best Fighters And Thinkers  Genetics research gets help from social media - Reuters  Experts warn consumers about genetic DNA screening scams  Transhumanism Is Tempting—Until You Remember Inspector Gadget | WIRED  Transhumanism and genetically altering people, today's great ethical challenge | ROME REPORTS  What is biohacking? The new “science” of optimizing your brain and body. - Vox  Scientist develops novel algorithm to aid search for exoplanets  Non-addictive CRISPR-edited tobacco could help eliminate smoking | New Scientist  "This is crazy!"—Top Scientists Condemn Russian's Plan for CRISPR Babies | BioSpace  The Art of Gene-editing Butterflies (Painting With CRISPR) Video | Technology Networks  CRISPR in Russia: The World's Next Gene-Edited Babies May Not Be Far Away  Using CRISPR to resurrect the dead - CNET    THE NEW AGE AND OCCULT IN THE NEWS The Witches are Back  The Modern Witch – XPRESS MAGAZINE  On Digital Mysticism    FOUR HORSEMEN OF THE TECHNOCALYPSE Elon Musk's 'Moon Mix-Up' Was Actually an Epic Bezos Troll  Elon Musk: Here’s Why World Population Will Start To Collapse Soon | Daily Wire  Elon Musk bewilders Twitter users with tweet about Mars  Tesla close to quarterly delivery record, Elon Musk says in email - Business Insider  Washington town where Jeff Bezos, Bill Gates live is having a budget crisis | Fox Business  Jeff Bezos says going to the moon is harder now than it was for JFK – GeekWire  Bernard Arnault, Jeff Bezos, Bill Gates Worth $100 Billion Each - Bloomberg  Even Bill Gates pronounces ‘Bezos’ wrong — here’s how to say the Amazon CEO’s name – GeekWire  Mark Zuckerberg to speak at Aspen Ideas conference - CNN  Mark Zuckerberg deepfake video: Why Facebook hasn't taken it down yet - Business Insider    CRYPTOCURRENCY & THE B-B-B-BLOCKCHAIN Salesforce Explores Blockchain To Stop Biased Robots From Ruining $1 Trillion Opportunity    SOCIAL MEDIA/GOOGLE/AMAZON Designers built an AI penis detector to protest Google’s prudish doodles - The Verge  Senator Markey Asks FTC to Force Google to Delete Data on Minors - Bloomberg  Google Chrome now lets you flag sketchy websites - CNN  Thune Wants Google and Facebook to Have Algorithm-Free Options - Bloomberg  Google Responds to Claims That Maps Has Millions of Fake Business Listings  Google's new curriculum teaches kids how to spot fake news and URLs - TechSpot  How Google searches might be able to predict the 2020 Democratic race - CNNPolitics  Amazon overtakes Google and Apple to become the world’s most valuable brand | TechRadar  Google warns its employees that Pride protests are against the company’s code of conduct Amazon is leasing more planes so it can deliver packages on its own - CNN  Amazon receives US patent for surveillance as a service — Quartz  32 Mind-Blowing Amazon Statistics for 2019  Walmart and Amazon want to see inside your house. Should you let them? - Los Angeles Times How to stop Amazon ads, Alexa from tracking you  Brazil court slashes fine for Facebook's refusal to share WhatsApp data - Reuters  Facebook is building a dedicated news tab for publishers - Business Insider  Why the Lonely Stand to Lose the Most from Facebook | Psychology Today

CRISPR stands for clustered regularly interspaced short palindromic repeats. Long name, but easy to picture: the sequence is synonymous to a word processor for a book, the book being DNA, which allows scientists to not only read the book, but to also edit a specific 'passage' of the book. Using CRISPR technology, DNA edits were performed on female twin embryos by Chinese scientist Jiankui He, who has since lost his standing in the scientific community. Xinzhu Wei & Rasmus Nielsen, from the University of California Berkeley, followed up with the birth of the twins in an article published in... Like this podcast? Please help us by supporting the Naked Scientists

CRISPR stands for clustered regularly interspaced short palindromic repeats. Long name, but easy to picture: the sequence is synonymous to a word processor for a book, the book being DNA, which allows scientists to not only read the book, but to also edit a specific 'passage' of the book. Using CRISPR technology, DNA edits were performed on female twin embryos by Chinese scientist Jiankui He, who has since lost his standing in the scientific community. Xinzhu Wei & Rasmus Nielsen, from the University of California Berkeley, followed up with the birth of the twins in an article published in... Like this podcast? Please help us by supporting the Naked Scientists

CRISPR Cas9 has been in the news a lot lately, good and bad. This week I finished my CRISPR Cas9 experiment where I genetically modified a sample of E. coli to have it grow in a usually fatal environment. Read the article to learn more!

Join Dr. Jason Reed as he describes a novel method by which endonuclease-inhibited Cas9 can be employed as a programmable biomarker in high-speed atomic force microscopy (HS-AFM) imaging. In this webinar, you will learn: 1. How CRISPR/Cas9 can be used to "flag" alterations and mutations in DNA, rather than cut it 2. How pairing atomic force microscopy (AFM) with optical equipment found in DVD players can be used to map DNA at a faster rate than traditional DNA sequencing 3. Applications of this technology, particularly in relation to discovering and diagnosing genetic diseases Since the diameter of the Cas9 molecule is greater than that of DNA, they are easy to locate along the DNA strand. Taking advantage of this, Jason's lab reported approximately 90% Cas9 binding accuracy to DNA molecules under optimized conditions. The alignment of single-molecule maps with nanoscale resolution becomes far more computationally straightforward than if labels are localized with multi-kb ambiguity. This process yields reduced processing time and cost for assembling a consensus map. Given its single-molecule sensitivity, approximately 15 bp accuracy, and no amplification requirement, Dr. Reed's novel method is amenable to small sample sizes. This proves to be an advantage in clinical situations where obtaining the almost 10 μg of DNA required for single-molecule sequencing is extremely difficult—if not impossible!

Alison Van Eenennaam is a geneticist at UC Davis, primarily interested in using CRISPR and other DNA-based biotechnologies in cattle production and agricultural systems. Learn about her exciting projects, ranging from "All Boys" cattle to hornless dairy cows, and the technical difficulties of working with large mammals in this episode.

Dr. Alejandro “Alex” Chavez, MD, PhD, assistant professor of pathology and cell biology at Columbia University, provides a detailed overview of the advances in CRISPR/Cas9 technology. CRISPR/Cas9 is a genome protection system utilized by many microbes to prevent foreign DNA and nucleic acids from infiltrating their genomes and potentially causing damage. Gene editing (changing the sequence of DNA) is not a new development, but the CRISPR/Cas9 technology allows for greater efficiency with gene editing at a lowered cost. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats, and the Cas9 essentially acts, as Dr. Chavez states, like a targeted missile. It works by taking small pieces of a genome and utilizing Cas9 to target or hunt down other copies of the sequence. As researchers learned more, the push to increase human gene editing, to target and attack specific genes reached an intense demand, for the potential for medical and scientific breakthroughs is immense. As Chavez explains, once Cas9 learns that a particular sequence belongs to a virus it will then seek it out, bind to it, and cut it, thus rendering it ineffectual. And as the defense effect takes hold, it strengthens other DNA in a system increasing resistance overall. Dr. Chavez discusses how the use of Cas9 has to be extremely specific, as Cas9 is so hard-working that it's essential that it be carefully planned so as to attack only the intended target. The cell biology expert provides an overview of restriction enzymes and the targeting and cutting of DNA. As he states, with CRIPSR, researchers can target literally anything they want, making it more efficient in research as a precision tool. Dr. Chavez explains the remarkable possibilities that CRISPR technology has created, as it can be utilized to turn single genes off, one by one, to see what happens, thus allowing for a systematic pattern of research. But as CRISPR is excellent at cutting genes off, there hasn't been an easy way to use CRISPR to turn genes on, so as the cell biology professor explains, their research features study in this area. He expresses the importance of seeing the gene in various ways, to have two different pictures of what the gene is doing. Chavez's lab built a tool that allows researchers to use CRISPR to turn genes on, which gives researchers a deeper look into the gene's actions and how it works. Chavez discusses Cas9 variants in terms of how they are utilized, their specificities, and how they cut DNA. He explains that while the variations are many, most researchers use Streptococcus pyogenes Cas9 (SpCas9) due to its overall efficiency, for as Chavez states, it's a jack of all trades. The genome researcher provides information on some future developments on the horizon, such as in vivo recorders that make physical copies of events within the genome, and the packaging of CRISPR for sterilization in medical procedures. Additionally, he explains how CRISPR specificity can allow more targeted cutting such that an exact area can be cut to specifically kill only the part of a bacterium that is harmful. With the advances in CRISPR, Chavez's lab is diving deeper into study of neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as others, to understand the biology of diseases.

Helen Lee Breton is a researcher who works in Dr. Chen's lab. Scientists at Texas Biomed are using CRISPR technology to try to create a new animal model for liver cancer. Liver cancer can have its roots in infectious diseases or metabolic conditions. And it’s a killer worldwide. Promising therapies developed in mouse models have failed in humans. So the experts at the Southwest National Primate Research Center think a bigger animal like a monkey might work better. The Southwest National Primate Research Center at Texas Biomed is home to more than a thousand of these Old World monkeys. CRISPR came on to the scientific scene in 2012. Christopher Chen, Ph.D., says it’s really making a huge impact in labs around the country.  

This episode: Scientists study how fungi make interesting peptides using large proteins instead of ribosomes. Download Episode (8.7 MB, 9.5 minutes) Show notes: Microbe of the episode: Nerine virus X News item Journal Paper: Yu D, Xu F, Zhang S, Zhan J. 2017. Decoding and reprogramming fungal iterative nonribosomal peptide synthetases. Nat Commun 8:ncomms15349. Other interesting stories: Using CRISPR to encode a short movie into a bacterial genome (paper) Virus that tolerates boiling acid could be model for super-tough nanomaterials Avoiding microbiota disruption protects frogs from parasites Soil microbe communities are also recovering in prairie restoration Couples modify each other's microbe communities, though not much   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook

This episode: Even organisms as simple as viruses can communicate with each other! Download Episode (12.7 MB, 13.9 minutes) Show notes: Microbe of the episode: Sweet potato virus C Commentary (paywall) Great talk about bacterial communication by Dr. Bonnie Bassler Journal Paper: Erez Z, Steinberger-Levy I, Shamir M, Doron S, Stokar-Avihail A, Peleg Y, Melamed S, Leavitt A, Savidor A, Albeck S, Amitai G, Sorek R. 2017. Communication between viruses guides lysis–lysogeny decisions. Nature 541:488–493. Other interesting stories: Engineering gut bacteria to detect and report gut inflammation Plants give fat to their root fungi in exchange for other nutrients Gut microbe metabolite linked with lower risk of diabetes Making bioelectrodes by embedding bacteria in glass (paper) Using CRISPR to discover new drug-producing bacterial genes   Post questions or comments here or email to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook

Scientists have found a way to remove the HIV virus from the DNA in mouse cells using CRISPR/Cas9 technology. According to the journal, Molecular Therapy, use of the technique has led to the complete elimination of infection in mouse organs and tissue after just one treatment. Now, that's the kind of international tech news that really gets us excited around here! And, yes! The team at the African Tech Round-up is back from a much-needed break, and we're super-stoked to catch up on news like this CRISPR HIV breathrough, as well as dive into some of the other significant headlines that dropped while we were away. We're pleased to announce that Musa Kalenga will be joining Andile as a guest co-host on the show every fortnight starting this week to chat about the most important stories and to unpack major trends impacting Africa's tech ecosystem. Music Credits: Music by Kevin MacLeod (incompetech.com) Music licensed under Creative Commons: By Attribution 3.0

In this episode, we explore the origins of plant domestication at the genetic level. Is plant domestication that different from genome editing and are GMOs different from "non-GMOs"? You've probably heard the buzz around CRISPR for modifying genes, and treating cancer, bu you may have no idea what CRISPR is. We go deep into CRISPR in this episode in order to understand how we can modify and edit the genome of plants we consume.