Podcasts about soce

Today's guest is Adam Barlow-Thompson. Adam is the Co-Founder and Executive Director of the Neighboring Movement. We talk all about what it means to be a good neighbor, what it is like living in the SoCe neighborhood, and how Wichita can be a better place 8 doors at a time. […] The post Adam Barlow-Thompson – Co-founder and Executive Director of The Neighboring Movement (TNM) in Wichita | Wichita Life Podcast #84 appeared first on Wichita Life.

De vez en cuando esta bien salir del estudio, sobretodo para Carlos, el técnico de sonido que hace que todo funcione y siempre esta metido en la pecera... asi que los Barberos se lanzan de nuevo con un episodio en directo desde Málaga en el congreso de odontología digital, van dando vueltas a distintas situaciones clinicas y ven como las enfocan cada uno.

On today's show, Tyler O'Neil sits down with Father Paul Sullins, senior research associate at the Ruth Institute and a former sociology professor at Catholic University, to discuss his research into "sexual orientation change efforts." Sullins analyzes the best data on how people who identify as homosexual have fared after undergoing therapies to address psychological issues that might underlie their same-sex attraction. While many U.S. states and health organizations claim that these efforts, often branded "conversion therapy," increase the risk of suicide, Sullins finds the exact opposite. LGB people who underwent SOCE were actually less likely to have suicidal thoughts AFTER the therapy. This finding turns the literature on its head and suggests that therapy to resolve issues underlying same-sex attraction may help LGB people, even if such therapy does not lead them to reject homosexuality.Enjoy the show! Hosted on Acast. See acast.com/privacy for more information.

REGIONS: Comelec reminds BSKE bets to submit SOCE | November 29, 2023Subscribe to The Manila Times Channel - https://tmt.ph/YTSubscribe Visit our website at https://www.manilatimes.net Follow us:Facebook - https://tmt.ph/facebookInstagram - https://tmt.ph/instagramTwitter - https://tmt.ph/twitterDailyMotion - https://tmt.ph/dailymotion Subscribe to our Digital Edition - https://tmt.ph/digital Check out our Podcasts:Spotify - https://tmt.ph/spotifyApple Podcasts - https://tmt.ph/applepodcastsAmazon Music - https://tmt.ph/amazonmusicDeezer: https://tmt.ph/deezerStitcher: https://tmt.ph/stitcherTune In: https://tmt.ph/tunein #TheManilaTimes Hosted on Acast. See acast.com/privacy for more information.

Refute the Top 5 Gay Myths With this Incredible, Free eBook:https://ruthinstitute.org/top-5-myths Join us for exclusive, uncensored content on Locals: https://theruthinstitute.locals.com The Rev. D. Paul Sullins, Ph.D., is a Senior Research Associate of the Ruth Institute. He recently retired as Professor of Sociology at the Catholic University of America, Washington DC. Dr. Sullins is a leader in the field of research on same-sex parenting and its implications for child development. He has written four books and over 100 journal articles, research reports, and essays on issues of family, faith, and culture. His reports on clerical sexual abuse from the Pennsylvania Grand Jury data, John Jay data, LA Times, and other sources have garnered international acclaim. Dr. Sullins continues as Research Professor and Director of the Leo Initiative for Social Research at Catholic University, as well as Director of the Summer Institute of Catholic Social Thought. Formerly Episcopalian, Dr. Sullins is a married Catholic priest. He and his wife, Patricia, have an inter-racial family of three children, two adopted. He serves as Associate Pastor of the Church of Saint Mark the Evangelist, Hyattsville, MD. Walt Heyer is a husband, father and corporate executive who underwent gender reassignment surgery at the age of 42. After eight years of living as "Laura," Walt went back to himself, and has for 30 years sought to help others who regret so-called “gender change." His wife received him back and they have been happily married for 20 years. Walt has appeared on CNN, the BBC and Russia's Channel One, and scores of other radio and TV media including Laura Ingram, Glenn Beck and Candace Owens, and conferences around the world. He's written over 60 articles for USA Today, The Federalist, Public Discourse and The Daily Signal, and has authored 7 books, including “Trans Life Survivors” and “Paper Genders.” Sex Change Regret: www.sexchangeregret.com Walt's website: waltheyer.com Walt's story in brief: https://youtu.be/9lpkrPLHHHY I Want My Sex Back video: https://youtu.be/-pxxBQm114k Books, including "Articles of Impeachment Against Sex Change Surgery," "Trans Life Survivors," "Paper Genders," "Gender, Lies and Suicide," and "Perfected With Love": https://sexchangeregret.com/bookstore/ Heyer article "Rapid Onset Marxism": https://www.dailysignal.com/2021/01/26/its-not-just-gender-dysphoria-its-now-rapid-onset-marxism/ Heyer article "Ruining Young Lives": https://www.dailysignal.com/2020/01/02/transgender-clinics-are-ruining-young-lives/ Wake Up America: https://www.dailysignal.com/2022/01/05/wake-up-america-cultural-marxism-is-identifying-as-transgenderism/ More articles by Walt at the Daily Signal: https://www.dailysignal.com/author/walt-heyer/ About "Wolf In Sheep's Clothing" documentary: https://insideewtn.com/2020/10/17/watch-a-wolf-in-sheeps-clothing-ii-the-gender-agenda/ Purchase "Wolf In Sheep's Clothing" DVD: https://www.ewtnreligiouscatalogue.com/a-wolf-in-sheeps-clothing-ii-the-gender-agenda-dvd/p/HV00WGAD Fr Sullins' studies on Sexual Orientation Change Efforts (SOCE, "Conversion" Counseling): https://www.ncregister.com/interview/catholic-university-of-america-professor-pushes-back-against-reparative-therapy-studies and https://ruthinstitute.org/sexual-orientation-change-efforts-arent-harmful/ Fr Sullins' book "Keeping The Vow: The Untold Story of Married Catholic Priests": https://www.amazon.com/Keeping-Vow-Married-Catholic-Priests/dp/0199860041 Fr. Sullins' research summary, "Efficacy and Risk," makes the case that SOCE can be effective and with positive psychosocial benefits, and refutes a misleading but very promoted anti-counseling "study": https://f1000research.com/articles/10-222 A review of Fr. Sullins' study in Mercatornet. https://mercatornet.com/gay-conversion-therapy-can-work-no-matter-what-joe-biden-says/71620/ Fr. Sullins' research article, "Suicide and SOCE," rebuts an article claiming that SOCE increases suicide risk, showing that most of the suicide behavior occurred before going to counseling. (In fact, SOCE greatly reduces suicide risk.): https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3729353 Fr. Sullins' previous Dr. J Shows: www.YouTube.com/watch?v=6K7QgYOKThw http://www.ruthinstitute.org/dr-j-show/are-abortions-being-done-on-wanted-children-father-sullins-on-the-dr-j-show http://www.ruthinstitute.org/dr-j-show/new-years-resolutions Walt Heyer's previous Dr J Shows: www.YouTube.com/watch?v=6K7QgYOKThw www.YouTube.com/watch?v=zg56HcMQu6c Bill Burleigh on The Dr J Show: www.YouTube.com/watch?v=RF8qo2tig30 Laura Smalts on The Dr J Show: www.YouTube.com/watch?v=iLPsSWAHVPA Detrans on Reddit: https://www.reddit.com/r/detrans/

It's the same for me. It's just something I can do. What you can do is listen to us talk about double-momming Allen, wondering if Captain Matthews cuts Chris' lawn, seducing Shion with wine, firing 9MM bullets in space, excelling over others in one specific skill, going full Gendo Ikari, hearing Willhem introduce more vocabulary words, introducing another masked man mystery, watching a planet disappear, preparing Plan 31, sitting in obelisk chairs, talking about Councils of Fucked Up Guys, donating our bodies to Ziggurat Industries, requesting the deletion of neural memories, and being brought back to life against our will. We are the ones who determine life or death. 00:00 Anime | 01:17 Intro | 02:38 Woglinde Crew Meets Elsa Crew | 15:19 Gnosis on the Elsa | 24:30 Dämmerung | 32:53 Pleroma | 40:22 Fifth Jerusalem Orbit Tower | 58:07 Real Net | 01:01:57 Outro Get more Retrograde Amnesia: Support us on Patreon at patreon.com/retroam. Join the community and get early access, ad-free episodes, bonus episodes, miniseries, and access to the RealNet.  Twitter: @retroamnesiapod Cohost: cohost.org/retroam E-Mail: podcast@retrogradeamnesia.com Website: www.retrogradeamnesia.com  

On this episode of The Construction Record Podcast™, digital media editor Warren Frey speaks with Dr. Guido Wimmers, the new dean of the British Columbia Institute of Technology's School of Construction and the Environment. Wimmers talks about his initial impressions as he takes on his new role and his previous work both at the University of Northern British Columbia and in Europe, as well as his focus on wood design and sustainability. He also speaks to the partnership between trades training institutions and the wider construction industry and the potential of the school's Trades and Technology Complex, the largest project in BCIT's history. Daily Commercial News and Journal of Commerce editor Lindsey Cole also joins the pod with a series of headlines from across the country, including a story from DCN staff writer Don Wall about the Downsview community development in Toronto, a massive 30-year project that will when completed provide homes for 80,000 to 110,000 new residents and 47,000 workers. She also highlighted a recent talk at the Canadian Institute of Steel's Construction's conference in Toronto about prompt payment from Soloway Wright LLP partner Dan Leduc where he said that while there's a “scissor lift” for prompt payment, industry is still sticking to old habits or as he said is “still using a wooden ladder.” Lindsey also highlighted our Demolition feature, including an article from John Bleasby about the circumstances in which decommission, deconstruction and demolition should be implemented. From the west, she highlighted a story about a B.C. court rejecting a legal challenge by a resident's association to the large-scale housing development planned by the Squamish Nation at the foot of the Burrard Bridge in Vancouver. She also provided an update on the latest developments, with the North Shore Wastewater Treatment Plant Program, as Metro Vancouver appointed a task force to review available options towards completing the troubled project. You can listen to The Construction Record on the Daily Commercial News and Journal of Commerce websites as well as on Apple Podcasts, Spotify and Amazon Music's podcast section. Our previous interview with Soloway Wright LLP partner Dan Leduc about prompt payment in Ontario and elsewhere in Canada is here. Thanks for listening. DCN-JOC News Services Downsview project will serve as transportation, building lab There's a scissor lift for prompt payment but industry still using a wooden ladder: Leduc Decommission, deconstruction, then demolition, in that order B.C. court rejects challenge to huge Squamish Nation housing project in Vancouver Metro Vancouver to form North Shore Wastewater Treatment Plant task force

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.27.525873v1?rss=1 Authors: Poth, V., Do, H. T. T., Foerderer, K., Tschernig, T., Alansary, D., Helms, V., Niemeyer, B. A. Abstract: Balanced Ca2+ homeostasis is essential for cellular functions. STIM2 mediated Store-Operated Ca2+ Entry (SOCE) regulates cytosolic and ER Ca2+ concentrations, stabilizes dendritic spine formation and drives presynaptic spontaneous transmission and ER stress in neurons. Recently identified alternative spliced variants expand the STIM protein repertoire, uncover unique functions and facilitate our understanding of tissue specific regulation of SOCE. Here, we describe an addition to this repertoire, a unique short STIM2 variant (STIM2.3/STIM2G) present only in old world monkeys and humans with expression in humans starting with the beginning of brainwave activity and upon synapse formation within the cerebral cortex. In contrast to the short STIM1B variant, STIM2.3/STIM2G increases SOCE upon stimulation independently of specific spliced in residues. Basal cluster formation is reduced and analyses of several additional deletion and point mutations delineate the role of functional motifs for Ca2+ entry, NFAT activation and changes in neuronal gene expression. In addition, STIM2.3/STIM2G shows reduced binding and activation of the energy sensor AMPK. In the context of reduced STIM2.3 splicing seen in postmortem brains of patients with Huntingtons disease, our data suggests that STIM2.3/STIM2G is an important regulator of neuronal Ca2+ homeostasis, potentially involved in synapse formation/maintenance and evolutionary expansion of brain complexity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.13.523980v1?rss=1 Authors: Reyes Gaido, O. E., Schole, K. L., Anderson, M. E., Luczak, E. D. Abstract: Ca2+ is a fundamental determinant of survival in living cells. Excessive intracellular Ca2+ causes cellular toxicity and death but the genetic pathways contributing to Ca2+ induced cell death are incompletely understood. Here, we performed genome-wide CRISPR knock-out screening in human cells challenged with the Ca2+ ionophore ionomycin and identified genes and pathways essential for cell death after Ca2+ overload. We discovered 115 protective gene knockouts, 33 of which are non-essential genes and 21 of which belong to the druggable genome. Notably, members of store operated Ca2+ entry (SOCE), very long-chain fatty acid synthesis, and SWItch/Sucrose Non-Fermentable (SWI/SNF) pathways provided marked protection against Ca2+ toxicity. These results reveal pathways previously unknown to mediate Ca2+-induced cell death and provide a resource for the development of pharmacotherapies against the sequelae of Ca2+ overload in disease. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.21.521447v1?rss=1 Authors: Kaba, M., Carreras-Sureda, A., Nunes-Hasler, P., Demaurex, N. Abstract: Changes in membrane phosphoinositides and local Ca2+ elevations at sites of particle capture coordinate the dynamic remodeling of the actin cytoskeleton during phagocytosis. Here, we show that the phosphatidylinositol (PI) transfer proteins PITPNM1 (Nir2) and PITPNM2 (Nir3) maintain PI(4,5)P2 homeostasis at phagocytic cups, thereby promoting actin contractility and the sealing of phagosomes. Nir3 and to a lesser extent Nir2 accumulated in ER cisternae juxtaposed to phagocytic cups when expressed in phagocytic mouse fibroblasts. CRISPR-Cas9 editing of Nir2 and Nir3 genes decreased plasma membrane PI(4,5)P2 levels, store-operated Ca2+ entry (SOCE), and receptor-mediated phagocytosis, stalling particle capture at cup stage. Re-expression of either Nir2 or Nir3 restored phagocytosis, but not SOCE, proportionally to the PM PI(4,5)P2 levels. Phagosomes forming in Nir2/3-edited cells had decreased overall PI(4,5)P2 levels but normal periphagosomal Ca2+ signals. Nir2/3 editing reduced the density of contractile actin rings at sites of particle capture, causing repetitive low-intensity contractile events indicative of abortive phagosome closure. We conclude that Nir-mediated lipid transfer maintains phosphoinositide homeostasis at phagocytic cups, thereby sustaining the signals that initiate the remodeling of the actin cytoskeleton during phagocytosis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.14.516407v1?rss=1 Authors: Shin, K. C., Ali, G., Ali Moussa, H. Y., Gupta, V., de la Fuente, A., Kim, H.-G., Stanton, L., Park, Y. Abstract: Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder linked to numerous rare, inherited and arising de novo genetic variants. ASD often co-occurs with attention-deficit hyperactivity disorder and epilepsy, which are associated with hyperexcitability of neurons. However, the physiological and molecular mechanisms underlying hyperexcitability in ASD remain poorly understood. Transient receptor potential canonical-6 (TRPC6) is a Ca2+-permeable cation channel that regulates store-operated calcium entry (SOCE) and is a candidate risk gene for ASD. Using human pluripotent stem cell (hPSC)-derived cortical neurons, single cell calcium imaging, and electrophysiological recording, we show that TRPC6 knockout (KO) reduces SOCE signaling and leads to hyperexcitability of neurons by increasing action potential frequency and network burst frequency. Our data provide evidence that reduction of SOCE by TRPC6 KO results in neuronal hyperexcitability, which we hypothesize is an important contributor to the cellular pathophysiology underlying hyperactivity in some ASD. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.23.513385v1?rss=1 Authors: Hammad, A. S., Yu, F., Horgen, F. D., Machaca, K. Abstract: Store-operated calcium entry (SOCE) contributes to several physiological and pathological conditions including transcription, secretion, immunodeficiencies, and cancer. SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that STIM1 knockout (KO) metastatic MDA-MB-231 breast cancer cells migrate faster and have enhance invasion capacity compared to parental cells. In contrast, Orai1-KO cells, which have similar levels of SOCE inhibition as STIM1-KO, migrate slower than the parental cell line. This shows that the enhanced migration phenotype of STIM1-KO cells is not due to the loss of a Ca2+ entry through SOCE, rather it involves transcriptional remodeling. Interestingly, NFATC2 is significantly downregulated in STIM1-KO cells and overexpression of NFATC2 reversed the enhanced migration of STIM1-KO cells. This demonstrates that STIM1 modulates NFATC2 expression independently of its role in SOCE. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The journal Frontiers in Psychology published the latest study by Fr. Paul Sullins Ph.D. Senior Research Associate at the Ruth Institute, proving no harm is done by SOCE. This important research contradicts studies showing harm. Dr. Sullins explains his important research.  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.19.512717v1?rss=1 Authors: Harvey, K. E., Tang, S., LaVigne, E. K., Pratt, E. P. S., Hockerman, G. H. Abstract: The ER Ca2+ channel ryanodine receptor 2 (RyR2) is required for maintenance of insulin content and glucose-stimulated insulin secretion, in part, via regulation of the protein IRBIT in the insulinoma cell line INS-1. Here, we examined store-operated and depolarization-dependent Ca2+entry using INS-1 cells in which either RyR2 or IRBIT were deleted. Store-operated Ca2+ entry (SOCE) stimulated with thapsigargin was reduced in RyR2KO cells compared to controls, but was unchanged in IRBITKO cells. STIM1 protein levels were not different between the three cell lines. Basal and stimulated (500 M carbachol) phospholipase C (PLC) activity was also reduced specifically in RyR2KO cells. Insulin secretion stimulated by tolbutamide was reduced in RyR2KO and IRBITKO cells compared to controls, but was potentiated by an EPAC-selective cAMP analog in all three cell lines. Cellular PIP2 levels were increased and cortical f-actin levels were reduced in RyR2KO cells compared to controls. Whole-cell Cav channel current density was increased by 65% in RyR2KO cells compared to controls, and barium current was reduced by acute activation of the lipid phosphatase pseudojanin preferentially in RyR2KO cells over control INS-1 cells. Action potentials stimulated by 18 mM glucose were more frequent in RyR2KO cells compared to controls, and insensitive to the SK channel inhibitor apamin. Taken together, these results suggest that RyR2 plays a critical role in regulating PLC activity and PIP2 levels via regulation of SOCE. RyR2 also regulates {beta}-cell electrical activity by controlling Cav current density, via regulation of PIP2 levels, and SK channel activation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Do you have a loved one suffering from dementia? Are you worried about your own cognitive health as you age? If so, this episode of The Hormone Prescription Podcast is for you!   Our guest, Dr. Heather Sandison, the founder of Solcere Health Clinic, and Marama, the first residential care facility for the elderly of its kind, and a leading expert in the field of integrative medicine, shares her insights on how to protect your brain and prevent or reverse dementia.   In this episode you will learn: The role that hormones play in brain health The benefits of lifestyle changes, including diet and exercise, for cognitive health The genetic determinism of Alzheimer's disease and what you can do to mitigate your risk The tests and treatments available to prevent and treat dementia The complex system science approach versus the reduction approach to brain health And much more!   If you are interested in learning more about how to protect your brain and prevent or reverse dementia, this episode is a must-listen!   (00:00): Do you think that dementia is a done deal and that once you get it, you'll always have it. Well, you need to listen up because that's actually a lie.   (00:12): So the big question is how do women over 40, like us, keep weight off, have great energy balance. Our hormones in our moods feel sexy and confident and master midlife. If you're like most of us, you are not getting the answers you need and remain confused and pretty hopeless to ever feel like yourself. Again. As an OB GYN, I had to discover for myself the truth about what creates a rock, solid metabolism, lasting weight loss, and supercharged energy. After 40 in order to lose a hundred pounds and fix my fatigue. Now I'm on a mission. This podcast is designed to share the natural tools you need for impactful results. And to give you clarity on the answers to your midlife metabolism challenges, join me for tangible natural strategies to crush the hormone imbalances you are facing and help you get unstuck from the sidelines of life. My name is Dr. Kyrin Dunston welcome to the hormone prescription podcast.   (01:05): Hi, everybody. Welcome back to another episode of the hormone prescription with Dr. Kyrin. Thank you so much for joining me today. If you believe that dementia is a done deal in that, once you have it, you will always have it. It will progress and get worse. Then you need to listen up because that is just not true anymore. The truth is that you can prevent and reverse cognitive decline and Alzheimer's and other types of dementia. When you take a root cause all systems approach. And my guest today is an expert on this. She is going to break it down for you. She's also hosting a wonderful summit that is coming up on Alzheimer's and cognitive functioning and dementia and how to prevent and reverse it. So I definitely want you to attend that. We'll have the link in the show notes, because this is for everyone.   (02:00): You know, don't hear this title and think, oh, uh, my brain is fine, right? It takes decades to develop cognitive decline and dementia. And so if you have a brain, and you're a human, and you're getting older, which is just about every one of us, then you need to listen up, cuz you need to be doing things, taking steps to protect your precious brain, your mainframe computer. Now. So we'll dive into talking to Heather. She gave a masterclass today about all the things that you need to be doing for your brain. Don't be overwhelmed though, because in her summit she's going to go into with experts like me, way more detail. And of course I'm the hormone expert and hormones. You definitely need a prescription for hormones. If you want to protect your brain, you cannot have optimized brain function without it. So we'll dive into that, but I'll tell you a little bit about Dr.   (02:56): Heather and we'll get started. She's really rather remarkable. Dr. Heather Sandison is the founder of SOCE health clinic and MIMA the first residential care facility for the elderly of its kind at SOCE Dr. Sandison and her team of doctors and health coaches focused primarily on supporting patients, looking to optimize cognitive function, prevent mental decline and reverse dementia by addressing root causes of imbalance in the brain and body. This is something all of you should be doing. She was awarded a grant to study an individualized integrative approach to reversing dementia and is a primary investigator on the it H N C L R clinical trial at Marama. Dr. Sandison has created an immersive residential experience in the lifestyle proven to best support brain health. She understands that changing her diet, adding nutrients, creating community and optimizing a healing environment are all challenging. Even for those with full cognitive capacity at Marama, she's done the work for you, all you or your loved one need to do is show up. She is also the host of the reverse Alzheimer's summit and collective insights podcast, where she works to share what is possible for those suffering with dementia. Welcome Dr. Heather Sandison.   (04:23): Thanks. It's so exciting to be here with you.   (04:25): Yeah, I am so excited about your summit coming up. Many of my listeners know that my mom suffers with advanced Alzheimer's and I really I'm so passionate about helping others to know how to prevent and reverse cognitive decline. Cuz personally, I think it is the most devastating disease someone could be diagnosed with. How did you come to be so passionate about preserving cognitive capacity and preventing and reversing Alzheimer's?   (04:59): Well, as you know, it's an absolutely torturous disease, not only for the person experiencing it, but for all of their loved ones who have to watch this slow painful demise. And the reason I became so passionate was because there's a bit of injustice in this, right? I was told that there was nothing you could do for dementia by very well meaning very well educated instructors when I was in school just 10, 12 years ago, right? Like this is very recent history I was told. There's nothing you could do to suggest otherwise is to give someone false hope and that's just cruel. Right? So don't do that. And then fast forward a few years I saw Dr. Bison speak at a conference and I was really intrigued because his approach, he was saying, you could reverse dementia. You could reverse cognitive decline. And his approach made a lot of common sense.   (05:54): It just wasn't common practice to kind of put all of functional medicine together and apply it to someone with dementia. So what he was describing was BA essentially complex system science approach, the opposite of the reductionistic approach that conventional medicine has been taking for decades, where they try to create one pill or one IV formula that's gonna cure Alzheimer's right. And then everybody's gonna get on it and nobody's gonna have it again. Well, this is really a false premise. It doesn't work because it's based on this idea that beta amyloid plaques or tell proteins these pathological or, or histological really physiological changes. They're almost like scar tissue in the brain that they are the ones that cause dementia or, or Alzheimer's when in fact it's what causes that scar tissue is what causes dementia. And so what I saw after seeing Dr Bison speak was that I was intrigued, right.   (06:55): I, I was skeptical, but I was curious. And so like when I had and did his training, I came back to my office still skeptical, but my first patient Linda came into my office after I was on Dr. Bison's website. Right. I was on the list of people who had been trained by him. And so I had patients showing up asking, uh, because there weren't other people in San Diego who had been trained by him at that point. And so Linda came in with her husband, very enthusiastic, totally committed to doing everything she could. Now for your listeners who aren't familiar with a mocha score, this is the Montreal cognitive assessment. And it's a score out of 30. So 30 is perfect. We really wanna get over 26, especially as we're aging. And when we start to be able to measure cognitive decline. So this can be sometimes you hear this called mild cognitive impairment.   (07:46): And I won't go on the tangent about how I feel about that use of language . But as you get down into the teens, lower teens, this is Alzheimer's disease. This is relatively severe dementia, where you're having trouble taking, having a conversation. Maybe you get lost in familiar places. You aren't nonverbal. Like you can still have a conversation, but often you're repeating yourself. Unable to work is very typical at this stage. Now, by the time you get to a two, a three, a four, this person is, is answering with yes or no statements, right? They're they can't hold complex concepts in their mind. They can't hold questions for very long. And this is where Linda was. Linda was at a two out of 30. So she could answer with yes or no. Her handwriting had been affected. So it was a bit shaky. It was at a very severe slant.   (08:35): It was very, very small letters. Her relationship with her husband of course, was severely affected. They couldn't hold a conversation and he loved her so much. I mean, it was so inspiring to watch how committed he was to her and how much he wanted to work hard to get her back. And I could see in Linda, she had this big, bright smile, and she was in there. She wore these loud, amazing clothes, you know, lots of mismatch and lots of color and hats and accessories. It was just great. And you could see who she had been and these little remnants personality that were peaking through. Well, her and her husband went home and they got out of a moldy bedroom. She got hers removed from her mouth. She got on biodentical hormones. She started all of the supplements. They went fully keto. They started ballroom dancing three to four times a week.   (09:28): And they started walking like vigorous walking exercise every day of the week and low and behold, six, seven weeks later, she came back and her mocha was a seven. Her life had been transformed. So she was now bickering with her husband about something that had happened on the ride to the clinic, which I was just like in disbelief. I could, I thought, you know, I was looking at her mocha scores, her worksheets and going, did we do it wrong? Like, did we miss anything? Like I just, my brain couldn't process that this was possible because I had been told the old refrain that people are still told that, that you couldn't do this. That this was impossible that I started crying because I was like, wait, what? This really works. And especially, I didn't have the confidence that it would work with someone with such severe disease.   (10:18): So when I saw in that moment, when I saw what was possible for Linda, I mean, how could anyone not commit themselves to this for the rest of their lives, right? Like this is possible for Linda. Then what's possible for everyone else who is younger. Who's just noticing those first signs that their brain isn't working the way it used to 10 or five years ago. What's possible for people who know their genetic risk, if they can prevent it from ever even starting. We know that dementia, the changes in the brain, the inflammation, the toxic assaults, the, the infections, the imbalances that cause dementia, the trigger that scar tissue formation, those imbalances start decades before anyone notices changes in their cognitive function, in their memory. And so if we can intervene sooner, we can make Alzheimer's optional. People do not have to go down the torturous path that your mom has.   (11:19): You could be scared. Your children could be spar. The torture of having to watch that of having to put someone in a home because they don't feel like they have the capacity to both raise their own children, work their full-time job, manage their house and care for the, their debilitated loved one with dementia. My life's purpose is changing the narrative around this, which is why I was so grateful that you joined me on the reverse Alzheimer's summit to help me in this crusade around telling people that I'm sorry, respectfully. I disagree with your neurologist who told you here's acept and Meda. It doesn't work very well. Get your affairs in order. There's nothing else that can be done. There's actually an overwhelming amount that can be done to support someone who's noticing their memory fading.   (12:07): Oh my gosh. She said so much in there. And when you told Linda's story and how she and her husband just went and made radical changes in seven weeks had marked improvement. I cried because it's just such demonstrative of what is possible when people really take this seriously and they do all the things and they radically reevaluate and change their lifestyle. What is possible? It's sad to me that it requires us to have such pain in order to do it. We have to go so far that people aren't willing to do it, but I love that they did it. Oh my gosh. You've said so many things. all right. So let's dive into this, but I, I think this idea of complex systems science approach versus reduction approach really is the whole shift in paradigm in medicine that is about antiaging, metabolic, functional medicine.   (13:06): It is the healthcare revolution. It is the next frontier. There's so many areas where we take this reductionist approach. Like it's just a disease, it's just symptom management and you have to deal with it and you have to control it, particularly not only with dementia. I think dementia is where this shows up as just this hopeless attitude of, oh, this is it. Get your affairs in order here, take these medicines. They don't really help. So let's dive a little into all the things that you've got to do, but I wanna start by talking, you mentioned genetic risk and I know people have heard there's Alzheimer's gene. They can't, most people readily access this, or maybe they can maybe, you know, of a place that people can get this, unless their doctor orders it. Can you talk a little bit about the genetics? What is the genetic determinism level with Alzheimer's and what's available? Mm-hmm   (14:04): yeah, there's a lot of agency here, right? Like, so even if you have the worst genetics, there's still a chance that you'll be in the camp that doesn't get dementia. Right. So there it's much more about epigenetics than it is about genetics. Right? So that, that, the way I describe it to patients is it's as if an architect has written the, has drawn the plans for a house and that's your genetic, so that's the plan. And then where you build that house, if it's by the beach, or if it's up in the mountains or it's in the desert, if there's carpet or tile, or, you know, if it's facing east or west, if there's a happy family or a sad family in it, right? Like all of these epigenetic effects determine what that house ends up looking like. And, and if it's a great house to live in or not, and that's essentially your body, right?   (14:50): So there's this genetic plan. And then there's the phenotype or what actually gets expressed, which is the actual house that gets built. Right? And so what we put into that house, what we put into that house that, you know, houses our soul that is so critically important to how that plan gets manifested. And so when we look at genetics, there are a few things and we are now, uh, you do have to get it through a doctor, but we are now offering the Alzheimer's risk test. And this takes not only APO E for genetics. So APO E genetics, let me describe APO E real quick, because this is kind the one that people know the most about and is the most indicative of late onset Alzheimer's. So there are a very rare form of early onset Alzheimer's and this would be your AP P your amyloid precursor protein and your Priscilla one and two.   (15:41): We do not test for that. So for that, we have people go to a geneticist and, and understand their risk there. Now, even if they do have that risk, that elevated risk, we wanna be as proactive as possible, right? This just means you need to work a little harder than your neighbor or your spouse to do all of the things on the bison protocol and prevent this risk for manifesting. There is still a way this genetics are not determination, right? You, you, it's not black and white that you are destined to have, uh Alzheimer's if you have these genes. So, but what we wanna do is we wanna get on top of it faster. So then APO E APO E our ancestors all had APO E four, four, APO E basically predisposes you to create amyloid plaques earlier, quick, more quickly, when you are exposed to something that's causing inflammation in the brain.   (16:34): So amyloid and tell proteins that they're antimicrobial, they're there to protect us. So they've been vilified and conventional medicine as the cause of Alzheimer's, but they're actually there in response to a trigger in the brain. And so, if you are creating these quicker, you do have a higher risk of dementia. And what we see this also APOE also affects fat metabolism, particularly saturated fat metabolism. So if you have a co you have a copy from mom, a copy from dad, and if you have an APOE four from mom and an APOE four from dad, you have a 50% chance of developing dementia. So my job is to make sure you're in the 50% that never gets any sign of cognitive decline. Now, the general population has about a 13% risk of developing dementia. So this is a highly increased risk. Now, if you have an APO E there's two, three, and four, two is pretty rare, but a three, four, it happens.   (17:30): And this means you've got one, a three from mom or dad, and then a four from mom or dad. You have about a one in three risk of getting dementia. So again, I wanna keep you in that 66% that never gets dementia. Then if you have a, a two, three or a three, three or 2, 2, 1 of the other combinations without a four from mom or dad, then you have about a 9% risk of developing dementia. There's a little bit of protection actually from having an APOE two. So we use the Alzheimer's risk test, which takes another 112,000 single nucleotide polymorphisms, and takes them through an algorithm that was developed in the UK, and then gives someone a score. A very it's easy to look at, right? It's not a lot of snips. It's not one of these kind of through the internet, you get your raw data things.   (18:16): This is a, this gives you a score that has a, a lot of very sophisticated data. That's been compiled and then analyzed. And it gives you a score out of one. So one being very high risk, zero being very low risk, and it includes a O E four, but also other genetic snips, single nucleotide polymorphisms. So if I'm talking to someone who is, say the daughter of someone with dementia, or the son of someone with dementia, maybe even the sibling or cousin of someone with dementia, this is a great test to take because there are people with a O E four who actually have relatively low genetic risk. There are people without a O E force positive alleles who have relatively high risk. And so we don't wanna oversimplify. Uh, and this test is the most accurate in determining whether or not someone will develop dementia. It's even more accurate than looking at amyloid in say, imaging or cerebral spinal fluid, or however, they're they find, um, ways to do that. Now, uh, I think they might even have a blood test that's available for research.   (19:22): Okay. I know everybody's listening and, and really, I have never met a person who's not concerned about this. Although most women are most concerned about breast cancer. They're I think this is really where they should focus, because if you do get breast cancer in this day and age, you're most likely not going to diet from it, but an Alzheimer's dementia will certainly pause significant disability and premature death. So people can get this from your clinic. Can they get this from any doctor? Cuz I know there are women listening who are like, okay, I hear you, Dr. Heather, I need this test. Where do I get it?   (19:58): So anyone in the us can get it through our clinic. What we do is we have a doctor who will review it with you and then they can help you find a BR trained provider near you. If you have high risk, we're gonna wanna do that quick. But if you have low risk, you know what a relief. So we have a doctor who can help you get that test. It's it's a pretty new test. It's clear. So it it's not reimbursed by insurance yet. So it's on the cutting edge. It's used most commonly actually in the pharmaceutical industry so that the scientists there can determine who's at higher risk and then target those people for drug discovery and for, and for the, the science that they're doing. Now, we wanna apply this so that we can get people preventing dementia. And so that's why I've really done my best to make it as widely available as possible, even though not many doctors in the us are offering it. So through my clinic, anywhere in the us, you can get this test done. And then we'll, you'll talk to a doctor here at Ary who will talk you through the implications and, and the interpretation of that, and then help get you supported by the bison train provider who can take it from there.   (21:05): Okay. Awesome. And we will have the links and the show notes for all of this. So you can go there and get the links. And Dr. Heather has a great download for you, which will come to before we wrap up. So, okay. So we've got our risk, everybody. I think everyone should get checked now do not wait. And then let's talk about this complex system science approach versus reduction approach. You mentioned my favorite topic, hormone therapy. My mom was without hormones for, you know, over three decades. And that really was the only risk factor she had for dementia. And I am a huge proponent of the benefits of hormone replacement therapy. Not only for cognitive function, I mean, se what is it? 77 or 79% reduction in getting Alzheimer's if a woman is on hormone replacement therapy, I mean, that's just insane. It should be criminal not to give it   (22:05): Well, you, you mentioned the breast cancer risk, right? This is I think what, yeah, a lot of people from pulling the trigger on a hormone replacement and I think what you said was perfect, right? Like, no, of course we don't want anyone to get breast cancer. However, there's been a lot of data that was misconstrued by the media that was misinterpreted. You know, they've gone back to the women's health initiative study and put some caveats on this whole idea that there was an increased risk of breast cancer. That was with oral estrogens. That was when non-bio identical estrogens. So we're not talking apples to apples when we consider bio identical hormone replacement now. And when you think about aging and what's going to be the most torturous, the most debilitating, the most expensive breast cancer is highly treatable. We are so lucky that we live in a time when breast cancer is really highly treatable. Mm-hmm . So even if there is this like a little bit of increased risk, which my understanding of the data.   (23:05): Actually it's reduction, there's a reduction in risk of getting breast cancer. If you're on biodentical hormones. So you have a reduction in risk of breast CA of cancers. It all cause mortality, the, any reason for death, you have a reduction in risk for, and then the two things that affect women as they age, the most that are the most debilitating are gonna be a fall or dementia. These are gonna be the things that end you up in, in skilled nursing for too long, and then result in death and a torturous death where you're separated from your family, because you have to be in, in, in, you know, some kind of high acuity care and then dementia. I mean, this is torturous. Not only because just in and of itself, it's absolutely demoralizing. You lose all of your, of course cognitive capacity over time, but you also, you lose your dignity more than anything.   (23:54): And this can last for a decade or more. No one knows when the torture is going to end it also it's financially bankrupting, right? Not only is it emotionally bankrupting and exhausting for any caregiver, it is financially bankrupting as well. And so if we can prevent falls and we can prevent dementia by getting on hormones, particularly if someone already has say osteoporosis or risk of bone disease or has risk of dementia, either genetically or they're starting to notice changes, particularly as they go through menopause, then the risks are far outweighed by the benefits when we consider hormone replacement therapy, if it's bio identical and the estrogen is used topically.   (24:39): Yeah. So, so well said, thank you for sharing all of that. I agree. And wouldn't you say that the causes, uh, the factors that contribute to the creation of dementia are, are similar same factors to what contribute to bone thinning and osteoporosis.   (24:59): Absolutely. Well, that's one of the amazing things about this co this complex system science approach, right? Is that instead of saying, what's that one thing that causes dementia, what we say is, Hey, how can we get every cell in the body working and functioning better? And when we do that, well, low and behold, the side effects are that your blood pressure normalizes, your hemoglobin A1C goes back to normal. You no longer have diabetes, your osteoporosis starts to improve. Yeah. The, the kind of the four part approach to like my formula for osteoporosis is estrogen replacement with, of course with progesterone and testosterone got nice and balanced and help with muscle building. So biodentical hormone replacement with estrogen being most important there, vitamin D with K minerals and then, uh, weight bearing exercise. And with those four things, I also like to check osteocalcin and beta cross ops and the blood every six months and then a DEXA scan every two years. And with that kind of plan, that basic simple plan. I see the majority of my patients, their bones get stronger on Dexus year, uh, every other year when we check.   (26:07): Yes. Awesome. So I hope everybody's listening and taking care of these things. And I know in the summit that you're hosting, I'm super excited about it. You have experts that are gonna go in way more detail into all of these. So everybody listening needs to click the link in the show notes and sign up for that now, because you know, hopefully you're getting the, the message loud and clear that dementia is preventable and you can do things and you need, need to get on this early and often and take care of it. Or if you're already walking down that lane that you need to get out of it. So definitely wanna check that out, but briefly, what are some of the other factors I know you've touched on them. We've D we've talked about genetics in a little more detail, bioidentical hormones. What are some other factors that need to be addressed?   (27:02): Yeah, well, we're giving away the keto diet guide. So I wanna talk a little bit about the fuel that brain runs on. So the vast majority of us live our days in glycolysis burning sugar for fuel. So ATP is that fuel it's like that gasoline that gets our cells going. It gives them all the energy to make new memories, to make those connections in the brain. We've all had that feeling of being kind of tired and it's a heavy lift to do something mentally. Well, if we are on our burning sugar for fuel that over time as we age, our brains are less sensitive to both sugar and to insulin that allows the sugar into the cells from the blood into the cells to be turned into fuel. So this doesn't work as efficiently. Now this is regardless of if you have diabetes or insulin resistance, anyone as we age, if we have been on a sugar, uh, burning carbohydrates for fuel.   (27:55): And when I say sugar, I also be pasta bread, corn, you know, tortilla chips, all of the carbs, even squash and fruit. When we have been having consuming that every day for our entire lives, we don't get an opportunity to go into ketosis and burn fat for fuel. And so the brain starts to become less sensitive. It no longer efficiently burns sugar. And what we can do, this is the magic of the ketogenic diet is that we can flip the switch. We can turn our energy production from turning sugar into fuel, to turning fat into fuel and just switching the fuel. I mean, this is I, this is just divine design. It makes me I would get chills. When I think about how intelligent the body is and how is able to change out the fuel and burn it really efficiently. And so what people notice is that after getting on a ketogenic diet, they sleep better. They wake up with more energy, they lose weight. If that's the goal, cuz it's, it's very modulating for weight, their blood sugar improves and their memory comes back. They feel sharper cognitively. So I don't know if Kyrin you've ever been asked like, yo, is there a way that you can get more hours in my day? I just feel like there's not enough time   (29:16): For everything,   (29:17): Especially women, right? We're like doing so much constantly juggling and a ketogenic diet in my personal experience is the way to get another for me. I get another hour and a half in my day because instead of dragging myself out of bed at six 30 or seven, I'm up at five and I'm ready to go. This is certainly for me. I personally find it magic. And for so many of my patients, there was actually a, so many of my patients also report this. Now there was a, a trial done. It was a small feasibility trial of just nine participants. It was done in Florida and it was published in January of 2022 where they took nine again, nine participants with some co measurable cognitive decline. And they put them on a ketogenic diet for just six weeks. And they had statistically significant changes in cognitive functions. Six weeks later, if you were struggling with cognitive issues, this is the first spot. This is the first place to go. This does a lot of the heavy lifting. And I would say, this is about if I were to weight all of the interventions, cuz there's a lot, right? This can start to feel overwhelming and complex. But if I were to weight them, I would say the ketogenic diet does about half of the lifting.   (30:28): I love that you really put it into perspective. So it's not about weight. I think people hear keto diet and they think it's only about weight. And a lot of people don't have a weight problem, completely dismiss it, but you really highlight the importance of it and this metabolic flexibility and theology that you get with it. It's like the diet that keeps on giving. But do you think people should do it all the time?   (30:56): Yeah. Such a great point. I'm so glad you said that because no, it's just as bad to always be burning sugar for fuel as it would be to always be burning fat for fuel. So that term metabolic flexibility is really the goal. Our ancestors, our hunter gather ancestors did not have sugar available all the time. They did not have fat available all the time. They had periods of fasting. And so again, our divine design, the way we are, our design is to go back and forth between ketosis burning fat for fuel and glycolysis burning sugar for fuel. And when we, if our body, the chance to do that, the way our hunter gather ancestors did our body works better. It's almost, it's a bit of a stressor. This concept is called the hormetic effect or hormesis where we ask the body to be under a little bit of stress, just like exercise does this. Some calorie restriction or intermittent fasting can do this. And then the ketogenic diet is a fasting mimicking diet where we stress the body a little bit in order to get it to be more resilient. And so as we do that, we, we have, we also get, as you mentioned, auto, we senescent cells are kicked out of the system. We recycle them. We get rid of them. So that the cells that, that replace them are new and more efficient, more optimally functioning.   (32:17): Yes. Awesome. What other factors? So you, you laid it out keto diet as big does 50% of the heavy lifting. I love that. What are some other factors though that people might be alerted that they might need to attend to in   (32:31): Our practice at SOCE? And certainly through the medicine protocol, we wanna be comprehensive about how we do this. So there are two big things that increase my confidence that this approach is going to work one you're early on in the disease process. So you've just started noticing changes. If you even have it all the best is prevention, right, where you've never even noticed changes. So first thing that increases confidence is that we aren't waiting until the disease is severe. The second thing that increases my confidence is how comprehensive you can be about applying the treatment plan. So if you can do all of it, then my confidence goes through the roof. This is a lot like Linda. They did it all and they did it all right out of the gate and they got the benefits. So I get it. Not everybody's able to do that.   (33:15): And even small changes you will get benefit from. But as we stack them on top of each other, you get, you get this kind of virtuous cycle. They all work better when they work together. Okay. So we wanna be systematic about how we approach this and Dr. Bren trains providers this way. And certainly at Ary, we aim to be, uh, systematic and have check boxes, right? Because it can be a lot and feel overwhelming. So the way I think about it is we want to address there's five primary things that cause complex chronic disease. In my model, that it's toxicity, which have three flavors of toxicity microtoxins or biotoxins that come from the indoor air environment, most commonly heavy metals and then chemical toxins. These are things like petrochemicals. If you live near the freeway, this can be parabens, PCBs, SS, pesticides, herbicides, things that are in groundwater that contaminate groundwater, uh, those can come from lots of areas in the environment, but we can measure all three flavors of those toxins and then we can get them out and check that box that hopefully becomes something that you complete.   (34:21): So you get rid of all the mycotoxins get rid of all the metals, change up your environment at home or the personal care products or the cleaning products you use. And then we don't have to worry about that anymore, unless there's a new exposure. So toxins, I start there because that's a nice way to kind of check that box and move on. Now your cells can work better, cuz they're not defending you from toxicity or they're not, they're not trying to, uh, the way that Dr Renison puts it. It's great. Um, he says, imagine your brain is like a country. My brain is St right? You're focused on fighting off invaders like infections or defending from things like toxins. You're not building the infrastructure of new memories of roads and schools, right? In this analogy, you're not creating new memories. You're too busy defending, right?   (35:06): All of your resources are going in that direction. So we wanna get rid of toxins. We wanna have enough nutrients, right? We've gotta have the resources. We've gotta have the building blocks. We need those amino acids. We need those fats. We need those minerals to make all of these biochemical reactions that are necessary for memory building for quick thinking, we need all of those present. If we're depleted, then that's not going to happen efficiently. And then third, we wanna address stressors on the system. So this could be things like sleep deprivation. This could be as stress from, you know, psychosocial stressors, ort S D caregivers are very high risk of developing dementia. They have two and a half times the risk of the population, just because you're a caregiver for someone with dementia, because we often right caregivers wanna put the person they're caring for first.   (35:57): So they're not getting their own exercise. They're not getting enough sleep. It's highly stressful situation. So I really encourage caregivers to listen closely and prevent this disease. Managing stressors. I often will recommend meditation. Meditation is personally something I benefit from having a regular daily practice of mindfulness, meditation, prayer, whatever feels best for you. So managing stressors is another one. Then structure is another one. So we have toxins, nutrients, stressors, structures, structure is gonna be, is your airway open? Are you getting, are you getting oxygen to your brain at night? If you have sleep AP, even if it's mild sleep apnea, you wanna treat this aggressively. I don't care what sleep medicine says. If you are having apnea events at night, that is basically mild brain damage. And I am not okay with that. We have to treat. So whether that means going to your dentist and getting an oral appliance that keeps your airway open.   (36:59): Some people use the mouth tape. I know that sounds a little bit counterintuitive, but you can tape your mouth closed at night so that it forces you to breathe through your nose. Some people will get the nasal strips that, and I like the breathe, right? If you get the generics, they don't work as well. There's of course, the C a P the, the, which has forces pressure into the airway. The other thing that you can do is get the a, a P, and this is the Cadillac. What, from what my patients tell me, this is the Cadillac of C P much more Cadillac.   (37:30): Why is that? Why did they say that?   (37:33): The con, so the AAP is alternating pressure. So the C a P is continuous pressure. And so it doesn't matter what your body's doing. There's no feedback in the system. It just blows, you know, pressure in air I interior system. And when you use the AAP, it adjusts as you're sleeping as, and as you go into different events and then getting the mask that fits right or getting the pillow, whatever, I know that it can take effort going back and forth with sleep medicine, and it can be costly, but this is worth it. Find what works for you. And I've had patients say, oh, I feel like I'm gonna die when I have that mask on. And then it, I push them like, no, no, you've gotta figure this out and do something. Whatever works for you. And then, sure enough, a couple weeks later, they're like, I can't sleep without it.   (38:21): I it's changed my life because now I wake up feeling rested for the first time in a decade or more. So treating sleep apnea, excuse me, very, very important, getting enough, sleep enough rest. And then of course, you know, structurally traumatic brain injuries put people at risk for dementia. So again, the falls, you know, if a woman has a fall regularly and she's hitting her head, this is a really big deal. I'll also say here, the research on women and traumatic brain injuries is lagging behind because a lot of this is done on professional athletes and combat veterans, where there is an epidemic of untreated brain traumatic brain injuries that happens in women who are victims of domestic abuse. And I really hope that in the next couple of years, we see a lot more resources going into this because it's just such a tragedy.   (39:14): Just the way I think about our seniors, right? Who are unnecessarily suffering with dementia is that this it's the squandered resource. They are these people at the height of their wisdom and experience who are, are leaving society. And my job is to help bring them back into the fabric of society so they can be contributing to their families while women who are victims of domestic violence is a very similar thing, but almost just more awful to think about that. We don't know what the combination of asphyxiation. So if someone's being, this gets so graphic and Ugh makes me shutter, but someone who is being both strangled and having, getting traumatic brain injuries at the same time is really having severe detrimental effects on their brain. And we don't know what if progesterone is high. What if she's at a place in her cycle where progesterone is high or low or estrogen is high or low, and these things are happening at the same time and it's happening repeatedly, right?   (40:09): If this is something that ha occurs over and over again, what we see is that these women don't get the help that they need. We don't have the science going into what's going on. And then, because they have essentially a form of dementia, their social worker, who, whoever is there to help them, doesn't realize that maybe they're not working the plan. They're not following the instructions just because they're so overwhelmed and their brain isn't working any as well as it used to because of these injuries. So I really hope that, you know, as speaking to a female audience, there needs to be more compass. There needs to be more support for those who are suffering with dome domestic abuse. And we basically need to understand that they have a form of dementia. Structurally traumatic brain injuries are a very big deal, right? If you get hit over the head with a baseball bat, if you were in a car accident, if you've slipped and fall and hit your head and lose consciousness, even if you don't lose your con lose consciousness, if you have headaches or some sort of recovery time after this is a sign that you have inflammation in your brain, and there are things that we can do right away.   (41:17): Afterwards, we use IV N a D S choline, PSAL serum, high dose fish oils, high dose meth B12, and the sooner we can treat a traumatic brain injury, the better the, the potential that there will be significant recovery. So we talked about toxins, nutrients structure, and now infections. So therefore infections that really stand out here, what is herpes? So herpes. If you ever get outbreaks, whether they're cold sores on your mouth or genital herpes, you wanna treat this relatively aggressively. So I'm a naturopathic doctor, right? I got a big med per medication person, but when it comes to herpes and, and chronic herpes outbreaks, you wanna be treating that aggressively because that can trigger inflammation in the brain, right? We know that herpes kind of stays dormant in the nervous system. Well, whenever it gets retried, that is causing more inflammation in the brain. And this comes out of studies in Taiwan where there's big epidemiological data that showed that people who were treated aggressively with like a, an antiviral, a medication, a prescription antiviral had a lower incidence of dementia than those who had herpes, but were not aggressively treated with, with the pharmaceuticals.   (42:25): So we wanna be getting ahead of that, basically, making sure that those outbreaks are not happening regularly and work with your doctor, of course, on that. So herpes is one PGE GVAs is another. So this is oral health, making sure that there aren't infections in the mouth part of this is just geography, right? You, your mouth is pretty close to your brain. The other thing is that when you get, uh, many people will know that in dentistry, if you've had a knee replacement or a hip replacement, before you go in for a cleaning, you take an antibiotic. Well, the reason is because when you get that cleaning, it introduces those bacteria into your blood and it, that bacteria can then get onto that artificial joint and not be detected and create a, a big problem. It can also create heart disease. It can create cardiac inflammation, can lead to strokes and to cardiac events, and it can trigger the inflammation associated with dementia.   (43:20): So we want to make sure that our oral health, you health starts in the gut and the gut starts in the mouth. So this is really critical that we ha see, I think, a biological dentist we're getting cone being x-rays so that we're catching any insidious small infections in there, early on and effectively treating them. So we have herpes P and GVAs and Lyme disease. So neuro Lyme can be very debilitating. There's a lot of controversy in the field around Lyme, but my opinion is that that there's ly or co-infections present for anyone exhibiting symptoms of dementia, or Alzheimer's that you wanna aggressively treat that with a Lyme literate doctor and get rid of that once. And for all, a neuro Lyme can be very debilitating and also confusing because Lyme is the great imitator. So it looks like a lot of other things and will often go undetected.   (44:13): So anyone with dementia, I do screen them for Lyme and Lyme coinfections. And then the fourth one, many people are familiar with is COVID 19, right? So I know there are a lot of people who would not associate themselves with having dementia at all, but they've suffered with the brain fog following COVID and these viruses. And I think COVID was such a great illustration that it's really these foundations. And I would say it's stressors, structure, nutrients, and, and toxic burden that create whether or not we have balance in those, right? If we have balance the right amounts in the right places at the right times, we have the right amounts of things, then our immune system functions. Well, right. And these are the people who got COVID, but never had a single symptom. And then if we have a lot of imbalance in the system, these are gonna be the people who got COVID in either passed away, right.   (45:03): Unfortunately, or who suffered with long haul COVID right. There's alway already some sort of inflammation, some sort of imbalance. And then that virus comes in and the host that body, that house, that we're in succumbs to the perpetuating cytokine storms or whatever is next in terms of signaling that comes after that virus. And so we want to make sure we're getting that house in order those foundational pieces set. And also looking at that, you know, going back and reassessing, if somebody is struggling with long haul COVID, how can we optimize this? The function of every cell in the body, get those cytokines out. Plasmapheresis is something that's been looked at for dementia, as well as for long haul. COVID so DNRs or the Gupta program. I'm, I'm a fan of the Gupta program for retraining, the limbic system and helping with long haul. COVID there's a lot that we can do. But again, this is, this is part of that landscape of things that lead to dementia over time, that triggering of inflammation of that cytokine storm, that then trigger the production of beta amyloid plaques Andal proteins, which cause are related to, um, Alzheimer's dementia.   (46:18): Woo. Okay. Everybody take a deep breath. I know some people are hyperventilating right now, cuz they were with you on the keto diet and now they're like, oh, I have to do what. Okay. Just breathe. Y'all you're gonna go to the summit. Number one. And you're gonna get way more detail on everything. Dr. Heather has talked to you about today. So you're gonna know exactly what to do after you go to the summit. Exactly. So don't hyperventilate. You don't have to learn it all today and you're gonna go download her keto guide. Number one, we're gonna have the link in the show notes. Um, but I'll, I'll speak it out. It's SOCE right. S O L C E R e.com.   (46:59): Yeah. SOCE solutions for the Cerebra soul or soul shining light. Uh, like sun on the brain. SOCE   (47:06): There we go. Okay. So we'll have that in the show notes, we will have the link to join the summit in the show notes. So you definitely wanna go there. If you're driving, don't click it now, but wherever you're going, when you get there, click it and sign up. You will have experts. There are gonna tell you exactly what to do, including me. We'll talk about biodentical hormones. Of course, my favorite topic, Dr. Heather, thank you so much for this very insightful and inspiring. Look at dementia and Alzheimer's and how we don't have to go down that road. Have, you know, that story that the person's walking down the road and every time they walk down the street, they fall into the same hole. And then even though they try and go, the next time they try to walk around it, they end up falling in it and sometimes they walk past it, but then they end up falling in the hole and sometimes you, the person eventually learns that they can just go down a different street. So it kind of reminds me of that story. You can just go down a different street. People, you don't have to go down the street that most people in, in developed countries are going down towards, uh, dementia or cancer. All the things we're talking about also reduce your risk of cancer. Oh, by the way,   (48:21): All those scary diseases of aging. They are complex chronic diseases and conventional medicine, unfortunately does not shine in that space. Right? If you're in a car accident, if you have a bacterial infection, get to the ER, get to urgent care. But when we talk about diabetes, dementias cancers, this is really where we need to take a step back and take this more comprehensive complex system science approach and get all of those cells working optimally.   (48:50): Yes. Awesome. Well, thank you so much, Dr. Heather, we will see you at the summit. Thank you for joining us.   (48:55): Thank you so much. It's been such a pleasure to be here   (48:58): And thank you all for joining us for another episode of the hormone prescription podcast with Dr. Kirin. I know that you learned something that you can start implementing today in your life to improve your health and go down a different street. I look forward to hearing what that is. Join me on Facebook or Instagram at Kirin Dunston MD, and we will have a conversation about it. And until next week, peace, love and hormones y'all.   (49:25): Thank you so much for listening. I know that incredible vitality occurs for women over 40. When we learn to speak hormone and balance these vital regulators to create the health and the life that we deserve. If you're enjoying this podcast, I'd love it. If you give me a review and subscribe, it really does help this podcast out so much. You can visit the hormone prescription.com, where we have some free gifts for you, and you can sign up to have a hormone evaluation with me on the podcast to gain clarity into your personal situation until next time, remember, take small steps each day to balance your hormones and watch the wonderful changes in your health that begin to unfold for you. Talk to you soon.   Learn how to begin Keto, get food lists, how-tos, tips, and checklists from Dr. Heather Sandison's free Keto Diet Guide. Get it here: https://www.solcere.com/   Reverse Alzheimer's Summit 2022 How This One Diet Is Reversing Dementia... Plus 50+ Other Secrets for Protecting Your Brain From Alzheimer's Disease. We're breaking down the latest advancements in science, medicine, technology, neurology, nutrition, and more to help you reclaim your memories and your life at The Reverse Alzheimer's Summit 2.0   CLICK HERE to register.   Feeling tired? Can't seem to lose weight, no matter how hard you try? It might be time to check your hormones.   Most people don't even know that their hormones could be the culprit behind their problems. But at The Hormone Club, we specialize in hormone testing and treatment. We can help you figure out what's going on with your hormones and get you back on track.   We offer advanced hormone testing and treatment from Board Certified Practitioners, so you can feel confident that you're getting the best possible care. Plus, our convenient online consultation process makes it easy to get started.   Try The Hormone Club for 30 days and see how it can help you feel better than before.   CLICK HERE to sign up: https://www.thehormoneclub.com/home-page-essential  

Originally aired February 17, 2022 Published March 2, 2022 Taken from “Driving Home the Faith” with Fr. Rob Jack on Sacred Heart Radio In this episode of the Ruth Institute Podcast, we listen to Dr. Morse discussing with Fr. Rob Jack the recent appointment of Sam Brinton to the Office of Nuclear Energy. Amongst various aspects, Dr. Morse describes that some members of the federal government use appointments to flex the sexual revolution's muscles. Passing away are the days when the best person is chosen on account of merit. Also, Dr. Morse speaks of her interview with Susan Constantine, forensic body-language expert, who appeared on the Dr. J Show and spoke at the Summit for Survivors 2021. She teaches about duping delight and how Sam Brinton's story of torture in conversion therapy is almost certainly false. This same false story is being used to ban sexual orientation change efforts (SOCE) across the nation. Additionally, Morse mentions Fr. Paul Sullins research which examines statistics from the Williams Institute which demonstrates that SOCE are not harmful to individuals who receive this form of treatment. Listen to hear the full story.

The journal Frontiers in Psychology published the latest study by Fr. Paul Sullins Ph.D. Senior Research Associate at the Ruth Institute, proving no harm is done by SOCE. This important research contradicts studies showing harm. Dr. Sullins explains his important research.

While getting humans to Mars is likely to be one of the grandest challenges humanity has ever undertaken, getting them back could be even tougher. Researchers think sending genetically engineered microbes to the Red Planet could be the solution. Both NASA and SpaceX are mulling human missions to Mars in the coming decades. But carrying enough fuel to make sure it's a round trip adds a lot of extra weight, which dramatically increases costs and also makes landing on the planet much riskier. As a result, NASA has been investigating a variety of strategies that would make it possible to produce some or all of the required fuel on Mars using locally-sourced ingredients. While the planet may be pretty barren, its atmosphere is 95 percent carbon dioxide and there is abundant water ice in certain areas. That could provide all the ingredients needed to create hydrocarbon rocket fuels and the liquid oxygen needed to support combustion. The most ambitious of NASA's plans would be to use electrolysis to generate hydrogen and oxygen from water and then use the Sabatier reaction to combine the hydrogen with Martian CO2 to create methane for use as a fuel. The technology to do that at scale is still immature, though, so the more likely option would see methane shipped from Earth and oxygen generated in place using solid oxide carbon dioxide electrolysis (SOCE). That would still require 7.5 tons of fuel and 1 ton of SOCE equipment to be transported to Mars, though. Researchers from the Georgia Institute of Technology have outlined a new strategy in a paper in Nature Communications, which would use genetically engineered microbes to produce all the fuel and oxygen required for a return trip on Mars. “Carbon dioxide is one of the only resources available on Mars,” first author Nick Kruyer said in a press release. “Knowing that biology is especially good at converting CO2 into useful products makes it a good fit for creating rocket fuel.” The researchers' proposal involves building four football fields' worth of photobioreactors—essentially liquid-filled transparent tubes—which will be used to grow photosynthetic cyanobacteria. While it is possible to get these microbes to produce fuels themselves, they are fairly inefficient at it. So instead, they will be fed into another reactor where enzymes will break them down into simple sugars, which are then fed to genetically modified E. coli bacteria that produce a chemical called 2,3-butanediol. On Earth this chemical is primarily used to make rubber, and burns too inefficiently to be used as a fuel. But thanks to Mars' low gravity, it is more than capable of powering a rocket engine there, and also uses less oxygen than methane. “You need a lot less energy for lift-off on Mars, which gave us the flexibility to consider different chemicals that aren't designed for rocket launch on Earth,” said Pamela Peralta-Yahya, who led the research. The process also generates 44 tons of excess oxygen that could be used for life support. The one catch is that if the system was built with today's state-of-the-art technology, it would require 2.8 times as much material to be delivered to Mars compared to the most likely NASA strategy. However, once there it would use 32 percent less power, and resupply missions would only need to carry 3.7 tons of nutrients and chemicals rather than 6.5 tons of methane every time. And modeling studies suggest that by optimizing the biological processes involved and designing lighter-weight materials, a future system could actually weigh 13 percent less than the NASA solution and use 59 percent less power. The biggest barrier at the minute might be the fact that current NASA regulations prohibit sending microbes to Mars due to fears of contaminating the pristine environment. The researchers acknowledge that they will have to develop foolproof biological containment strategies before the proposal could be seriously considered. But if we want to make round trips to Mars a regular f...

Jo and J.J. welcome Reverend Erika Allison, Queer interfaith minister, speaker, author, and spiritual counselor. Rev. Erika talks about her own experience with conversion therapy, and how harmful it can be, causing long-term effects and even high cases of suicide. She talks about her healing and recovery, and the choice to forgive and let go of anger. Her book, Gay the Pray Away, guides readers on their own journey and can also serve as a powerful resource for someone who has a loved one coming out as a member of the LGBTQ+ community. She, Jo, and J.J. send a message to parents that almost anything can be worked through, and as more structures fall apart, we will welcome people more for who they truly are with open hearts.   Takeaway: [3:24] Rev. Erika experienced firsthand how critical of an issue mental health is. She experienced conversion therapy and the lifelong healing journey that came with it. A staggering statistic is that if you come out of conversion therapy alive, you have a 92% chance of lifetime suicidal ideation. Mental health is something Rev. Erika is committed to working on forever, and her enthusiastic way helps even the most resistant person listen. [6:49] Conversion therapy is an attempt to change someone's orientation or gender identity. It can be done for social reasons, religious reasons, and many times it's out of love and fear on the part of parents and family that the person will go to Hell, etc. This makes it even more confusing, and even though it has been widely discredited by professional mental health and medical organizations, it still goes on today. SOCE (sexual orientation change efforts) believes homosexuality is a curable disease, which can cause a profound amount of harm to an individual. [11:29] Fear can cause us to lessen the ability to think critically and believe whatever outside authorities tell us. In families worried about their children being queer, they can revert back to believing whatever “the man” tells them. This can mean a religious figure, a doctor, etc. [12:59] Rev. Erika talks about the long-term implications of her conversion therapy. She thought that because it hadn't changed her sexual orientation there was no damage done, but she had to do a lot of work on how it affected her level of trust in relationships and the shame that came with the therapy. [15:19] We tend to think our trauma isn't as bad or important as someone else's, but that can hold us back from healing. For Rev. Erika, the more she journaled, the more she tapped into her subconscious mind and saw harmful beliefs and blind spots that were scary, but necessary as part of the work. [18:34] Jo has always been very academic, and the more work she did, the more she saw her beliefs that her parents telling her to “do her best” meant to her to “be the best”. This put a large amount of pressure and stress on her, feeling as though she was a failure and defective if she wasn't at the top. [21:37] Rev. Erika sought out communities that took responsibility for the impact of their intentions, words, and behavior. This is where Buddhism helped, and meditation and mindfulness helped her detach from her thoughts and become more of an observer. [23:38] Conversion therapy can make someone feel as though they can't trust themselves or their gut feelings. Rev. Erika saw this clearly when she hired a coach to help her breakthrough professional and personal barriers, and they commented that she had one foot on the gas, and also one foot on the brake. On the one hand, she was forging forward with her work and her message, but at the same time, there was something holding her back, stopping her from stepping completely into her work.  On reflection, she realized that she was trying to protect herself from someone saying something or judging her in a way that triggered beliefs she had about herself. She, Jo, and J.J. discuss how triggers are our responsibilities too, and you can only get triggered by something still activated in you. Many times people hate on us because we trigger something in them. [30:19] Rev. Erika talks about viewing her inner critic as one voice at the conference table. It gets a say and it's part of what makes her up as a human being, but it doesn't call the shots. The more we can integrate our inner critic with our other parts, the less we resist it. [37:12] Our inner critic is just one truth, not THE truth. Each voice has their role, whether they are trying to keep us safe or get us to the next level of life. [41:35] Through Rev. Erika's work, she enthusiastically brings the message of self-acceptance into the world. We are now in a time where many systems are crumbling, and while scary, that can be good for shedding the old and stepping into our new more healing and true potential. [44:31] People like Rev. Erika who have gone through such dramatic trauma and healing can light the way for others. [47:05] J.J. has an important message for parents whose children come out: queer teen suicide is much higher than you may think. Learning this may be hard for you, but think: would you rather have them alive and queer or face the other option? You can work through almost everything, but you can't work through suicide. [49:06] Rev. Erika talks about her decision to let go of anger and forgive. It doesn't make her story invalid or take away what happened to her but helps her move forward. In her mind, she wrote a letter to herself from her mom's highest self, and it shifted their relationship completely. Soon after, her mom wrote an email and apologized to her. When you shift things, it instigates an energetic shift from fear to love.   Connect With Us: Joanna Denton | Dr. J.J. Kelly   Rev. Erika Allison | Gay The Pray Away    Big Magic You are a Badass  Taming Your Gremlin 

The Rev. D. Paul Sullins, Ph.D., is a Senior Research Associate of the Ruth Institute. He recently retired as Professor of Sociology at the Catholic University of America, Washington DC. Dr. Sullins is a leader in the field of research on same-sex parenting and its implications for child development. He has written four books and over 100 journal articles, research reports, and essays on issues of family, faith, and culture. His reports on clerical sexual abuse from the Pennsylvania Grand Jury data, John Jay data, LA Times, and other sources have garnered international acclaim. Dr. Sullins continues as Research Professor and Director of the Leo Initiative for Social Research at Catholic University, as well as Director of the Summer Institute of Catholic Social Thought. He also serves on the board of the Society of Catholic Social Scientists (SCSS), the Center for Family and Human Rights (C-FAM), and the Natural Family Journal. He is a Fellow of the Marriage and Religion Research Institute (MARRI), and was an Ignatius Loyola Fellow for Catholic Identity at the Center for the Advancement of Catholic Higher Education. Formerly Episcopalian, Dr. Sullins is a married Catholic priest. He and his wife, Patricia, have an inter-racial family of three children, two adopted. He serves as Associate Pastor of the Church of Saint Mark the Evangelist, Hyattsville, MD. This is an audio podcast of The Dr J Show. Full video episode is available here, with readings and resources.

A Classic RISK! episode from our first two years! In our eighteenth episode, storytellers Samara Doucette, Kevin Allison, Sara Barron, and Soce the Elemental Wizard talk about ways they're different from the average bear.               Support RISK! on Patreon at Patreon.com/RISK Make a one-time donation to RISK! at PayPal.me/RISKshow Get tickets to RISK! live shows at RISK-show.com/tour Get the RISK! book at TheRISKBook.com Get RISK! merch at RISK-show.com/shop Take storytelling classes at TheStoryStudio.org Hire Kevin Allison to make a personalized video at Cameo.com/TheKevinAllison Hire Kevin Allison as a coach at KevinAllison.com See omnystudio.com/listener for privacy information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.13.379982v1?rss=1 Authors: Thiel, G., Tandl, D. H., Sponagel, T., Fuck, S., Smit, T., Hehlgans, S., Jakob, B., Fournier, C., Roedel, F., Roth, B., Moroni, A. Abstract: Radiation therapy is efficiently employed for eliminating cancer cells and reducing tumor growth. To further improving its therapeutic application it is mandatory to unravel the molecular effects of ionizing irradiation and to understand whether they support or counteract tumor therapy. Here we examine the impact of X-ray irradiation on immune activation of human T cells with single doses typically employed in tumor therapy. We discover that exposing cells to radiation triggers in a population of leukemic Jurkat T cells and in peripheral blood mononuclear cells (PBMCs) a canonical Ca2+ signaling cascade, which elicits immune activation of these cells. An early step in the signaling cascade is the initiation of sustained oscillations of the cytosolic Ca2+ concentration, an event mediated by store operated Ca2+ entry (SOCE) via an X-ray induced clustering of the Calcium Release-Activated Calcium Modulator 1 with the stromal interaction molecule 1 (Oari1/STIM1). A functional consequence of the Ca2+ signaling cascade is the translocation of the transcription factor nuclear factor of activated T cells (NFAT) from the cytosol into the nucleus where it elicits the expression of genes required for immune activation. These data imply that a direct activation of blood immune cells by ionizing irradiation has an impact on toxicity and therapeutic effects of radiation therapy. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.16.285841v1?rss=1 Authors: Weiss, S., Clamon, L. C., Manoim, J. E., Ormerod, K. G., Parnas, M., Littleton, J. T. Abstract: Glia play key roles in regulating multiple aspects of neuronal development and function from invertebrates to humans. We recently found microdomain Ca2+ signaling in Drosophila cortex glia and astrocytes regulate extracellular K+ buffering and neurotransmitter uptake, respectively. Here we identify a role for ER store-operated Ca2+ entry (SOCE) in perineurial glia (PG), a distinct population that contributes to the blood-brain barrier (BBB). PG show a diverse range of Ca2+ oscillatory activity that varies based on their locale within the brain. Unlike cortex glia and astrocytes, PG Ca2+ oscillations do not require extracellular Ca2+ and are blocked by inhibition of SOCE or gap junctions. Disruption of these components triggers heat shock and mechanical-induced seizure-like episodes without effecting PG morphology or large molecule BBB permeability. These findings indicate SOCE-mediated Ca2+ oscillations in PG increase the susceptibility of seizure-like episodes in Drosophila, providing an additional link between glial Ca2+ signaling and neuronal activity. Copy rights belong to original authors. Visit the link for more info

First Hour (Mix 94) Burning Down the House – Talking Heads Something Just Like This – The Chainsmokers, Coldplay Rollin’ With Kid ‘N Play – Kid ‘N Play Dance Hall Days – Wang Chung Boasty – Wiley, Stefflon Don, Sean Paul, Idris Elba Rump Shaker – Wreckx-N-Effect Nothin’ On You – B.o.B, Bruno Mars Stayin’ […]

Check Out The Latest Mix By DJ Soce .. https://www.facebook.com/pages/DJ-Soce/1985791075005909  

Tawasi Soce is a gig driver - of people and packages - for various companies. He sent OPB recordings of what his days are like during the pandemic.

This episode presents the second part of hosts Adam and Matt's conversation with the most recent addition to the Neighboring Movement team: Riccardo Harris.In last week's episode, Riccardo detailed what his childhood neighboring was like, as he painted a picture of the neighborhood where he grew up. If you have not yet listened to that episode, titled "Riccardo Harris (Part 1): A Murmuration of Starlings", we would highly suggest doing so. During this week's episode, Riccardo tells about the many incredible things that he does, why he was drawn to the Neighboring Movement, and about his church in the SoCe neighborhood. As has been the case with some of our other episodes, this episode contains discussion of spiritual and religious topics. Because Riccardo is a Christian and his church in SoCe is a Christian church, Christian spirituality is referenced frequently throughout this conversation. As always, we want to reiterate that we do not present these episodes to promote any one spirituality or religion, Christianity included, but instead because we think they are helpful and encouraging for all neighbors, regardless of their relationships to spirituality or religion. We hope you enjoy the episode!If you would like to learn more about Riccardo and about a few of the many incredible things that he does, please visit the following sites:His website: https://www.riccardoharris.com/His church: https://www.resurrectioncc.net/His program: https://www.wichita.edu/administration/diversity/communityengagement/wichitagearup/index.phpHis book: https://www.amazon.com/gp/aw/d/0615692273/ref=tmm_pap_title_0?ie=UTF8&qid=&sr=

  First Hour (Mix 90) Fly Like an Eagle – Steve Miller Band Superstition – Stevie Wonder Just My Imagination – The Cranberries I Want You – Marvin Gaye A Passage to Bangkok – Rush Get Busy – Sean Paul Hips Don’t Lie – Shakira feat. Wyclef Informer 2018 – Snow vs Roton Romania Pray […]

First Hour(Mix 88) Counting Blue Cars (Tell Me Your Thoughts On God) – Dishwalla What Does Your Soul Look Like (Part 3 – In Tune and On Time) – DJ Shadow Roses – The Chainsmokers feat. ROZES Castle Theme – Dragon Warrior II Hold On, We’re Going Home – Drake feat. Majid Jordan Endegna | እንደኛ […]

First Hour  Informer – Snow feat. MC Shan Burning Heart – Survivor [From the Rocky IV soundtrack] Theme Song – Taiyo the Little Bus I Want You Back – The Jackson 5 What’s Love Got To Do With It – Tina Turner Crystal Blue Persuasion – Tommy James & The Shondells Good Kisser – Usher […]

First Hour  The Payback – James Brown Do It Again (Put Ya Hands Up) – Jay-Z feat. Beanie Sigel, Amil Blowin’ Me Up (With Her Love) – JC Chasez Love Don’t Cost a Thing – Jennifer Lopez Señorita – Justin Timberlake Alright – Freeway feat. Allen Anthony Better – Khalid Ramble On – Led Zeppelin […]

First Hour Llegaste Tú – CNCO, Prince Royce La La La La (Means I Love You) – HRVY feat. Stylo G Lo Que Pasó, Pasó – Daddy Yankee Mentirosa – Elefante Father Of Mine – Everclear When I Come Around – Green Day Hornet – Hollow Knight Always On Time – Ja Rule feat. Ashanti […]

First Hour Beef Jerky – Cibo Matto Grindin’ – Clipse Gonna Fly Now (Theme from Rocky) – DeEtta West, Nelson Pigford, Bill Conti This Time (I’m Gonna Try It My Way) Version 1 – DJ Shadow Loco Contigo – DJ Snake feat. J. Balvin, Tyga Taki Taki – DJ Snake feat. Selena Gomez, Ozuna, Cardi […]

First Hour Love On Top (LL Cool J Remix) – Beyoncé Oops!…I Did It Again – Britney Spears Speechless – Cibo Matto Primera Cita – CNCO Drivin’ Me Wild – Common feat. Lily Allen Literally Ill – Coolsay [Coolzey, Produced by Soce, The Elemental Wizard] Hide Away – Daya On Our Way Home – Empire Of […]

First Hour  Differently – Marian Hill Inner City Blues (Make Me Wanna Holler) – Marvin Gaye Not Today – Mary J. Blige feat. Eve NO – Meghan Trainor Genghis Khan – Miike Snow Next Universe – Mos Def Bouncin’ Back (Bumpin’ Me Against The Wall) – Mystikal I Just Wasn’t Made For These Times – […]

First Hour  Human Nature – Michael Jackson Get Over It – OK Go Hola – Ozuna Naskuot Overworld – Paladin’s Quest Gone – Kanye West feat. Consequence and Cam’Ron Imperials – Ratatat Sim – Anitta feat. Cone Crew I Love You – Soce, The Elemental Wizard feat. Navin Manglani Sola – MTZ Manuel Turizo Gonna […]

First Hour    Medellín – Madonna, Maluma Pretty Girl (Tu Canción) – Johann Vera Suprize Packidge – Mix Master Mike No Te Puedo Olvidar – Nicky Jam Updside Down & Inside Out – OK Go All Fall Down – OneRepublic Noches de Aventura – Ozuna Deep Water – Portishead Magnifique – Ratatat Amigos Con Derechos […]

First Hour La Respuesta – Becky G, Maluma Eastside – Benny Blanco, Khalid, Halsey Complicated – Dimitri Vegas & Like Mike vs David Guetta feat. Kiiara New Love – Dua Lipa Nine-Tails Vale ~ Home of the Youkai – Phoenix Wright: Ace Attorney: Dual Destinies Getting To The Point – Electric Light Orchestra Can’t Deny It […]

First Hour  Whatta Man – Salt ‘N’ Pepa feat. En Vogue 911 – Wyclef feat. Mary J. Blige Sólo Mía – Yandel feat. Maluma The Hardest Thing – 98º Sing Me To Sleep – Alan Walker feat. Iselin Solheim Se Que Soy – Amara La Negra Me Leva A Sério – Anitta Can’t Find My Way […]

First Hour Black Water – Doobie Brothers Hall Of Fame – The Script ft. will.i.am Mary Jane’s Last Dance – Tom Petty And The Heartbreakers Down Remix – Marian Hill ft. Soce, The Elemental Wizard Stressed Out – twenty one pilots Το Μαγαζί – Γιώτης ft Τσαλίκης Keep Ya Head Up – Tupac Bye Bye Bye – *NSYNC […]

First Hour Follow You Down – Gin Blossoms Eddie’s Gun – Rocky Horror Picture Show John, I’m Only Dancing – David Bowie Hey Ya – OutKast (Andre 3000) Happy – Pharrell Williams Shake It Off – Taylor Swift I’m Free (Heaven Helps The Man) – Kenny Loggins Let’s Twist Again – Chubby Checker A Taste […]

In this episode, Claudia Haupt, Associate Professor of Law and Political Science at Northeastern University, discusses her article, "Professional Speech," in the Yale Law Journal and her two successive articles, "Professional Speech and the Content-Neutrality Trap" and "The Limits of Professional Speech" published in the Yale Law Journal Forum. Haupt begins by stating the contours of professional speech as the dissemination of the common knowledge of a knowledge community in the learned professions. She discusses the role of professionals in an asymmetrical professional-client relationship within the protections of the First Amendment, within their role as contributor to a well-informed democratic polity, and within the regulatory environment established by states. She discusses recent circuit and Supreme Court decisions on professional speech in regards to sexual orientation change efforts (SOCE), crisis pregnancy centers, and restraints established by states to regulate professional speech, laying out the details of each case and discussing when the "First Amendment sword" should be used to protect professional speech. Haupt concludes by providing her insights as to how the framework of professional speech she advances should be taken by regulators, courts, and the general public. Haupt is on Twitter at @CEHaupt.This episode was hosted by Luce Nguyen, a student at Oberlin College and the co-founder of the Oberlin Policy Research Institute, an undergraduate public policy organization based at Oberlin College. Nguyen is on Twitter at @NguyenLuce. See acast.com/privacy for privacy and opt-out information.

First Hour Handyman – AWOLNATION Hévenu Shalom Aléchem – Barcelona Gipsy Klezmer Orchestra Sabotage – Beastie Boys The Longest Time – Billy Joel War Pigs – Cake (Black Sabbath cover) What You Won’t Do for Love – Bobby Caldwell King of Silence – Cibo Matto Shape of My Heart – Sting Lucid Dreams – Juice WRLD […]

First Hour Send My Love (To Your New Lover) – Adele Tell Me You Love Me – Demi Lovado Building Steam With a Grain of Salt – DJ Shadow Boo’d Up – Ella Mai Better – Fjer It Was a Good Day – Ice Cube Have It All – Jason Mraz Way Down We Go […]

First Hour  Lessons Learned – Matt & Kim We Can’t Stop – Miley Cyrus The Old Dance – Coolsay (Coolzey + Soce) [Brand New Unreleased Track!!!] This Too Shall Pass – OK Go Criminal – Ozuna X Natti Natasha Weatherpeople – RJD2 Empire – Shakira Buy U a Drank (Shawty Snappin’) – T-Pain Live Your Life […]

First Hour Preciso Me Encontrar – Cartola God’s Plan – Drake Try And Love Again – Eagles Heart Attack – Enrique Iglesias Stanky Legg – GS Boyz Mirrors – Justin Timberlake In Bloom – Nirvana Free to Be… You and Me – Marlo Thomas and Friends (The New Seekers) Dream On – Aerosmith What Does […]

First Hour Champagne Supernova – Oasis Alive – Pearl Jam Whatever You Like – T.I. Ride – Twenty One Pilots Say It Ain’t So – Weezer Tropicana – Alceu Valença Big Shot – Billy Joel One Love – Bob Marley Pra Nunca Mais Lembrar – Bruninho & Davi Beautiful – Christina Aguilera Lean Wit It, Rock […]

First Hour Working for the Weekend – Loverboy Animal – Neon Trees Dance, Dance – The Beach Boys Mr. Brightside – The Killers My Sharona – The Knack Gimme Some Lovin’ – The Spencer Davis Group Sk8er Boi – Avril Lavigne Banquet – Bloc Party Hollywood Nights – Bob Seger Holding Out for a Hero […]

First Hour  Right Here – Miley Cyrus The Cave – Mumford & Sons Lump – Presidents of The United States of America La Mordidita – Ricky Martin Real in Rio – Rio Soundtrack Simply Irresistible – Robert Palmer Marry You – Bruno Mars Dangerous – Cascada Flagpole Sitta – Harvey Danger Liar, Liar – The […]

First Hour  Hitchin a Ride – Vanity Fair Viva La Vida – Coldplay Say My Name — Destiny’s Child TKO – Justin Timberlake Scared To Be Lonely – Martin Garrix feat. Dua Lipa Underneath It All – No Doubt Boom, Boom, Boom, Boom!! – Vengaboys Sooner Or Later – Fastball Take It Easy – The […]

1st Hour Treasure – Bruno Mars Get Lucky – Daft Punk feat. Pharrell Williams and Nile Rodgers New Rules – Dua Lipa Layla – Derek and The Dominoes (Eric Clapton) Love Come Down – Evelyn “Champagne” King Boogie Shoes – KC and The Sunshine Band Stronger (What Doesn’t Kill You) – Kelly Clarkson Express Yourself […]

Flexx Bandss – Run It Up Single: Sol’Le – Mi Casa (Single) Single:  BQE ft Soce – Like2Know (Da Classics) Album: The DGM And The Dutch Henny B – My Kitchen Single: Arone – Insecure Single: AGZ – Ride On The Regular Remix Single: Swiezo x Bossy – Next Up Single: ArQuez – We The […]

Indu Ambudkar explains why radiation therapy for head and neck cancers causes dry mouth.

Carl White explains how the gaseous signaling molecule hydrogen sulfide suppresses calcium signaling in adipose tissue macrophages to limit inflammation.

NYC based Comedian Nancy Lombardo, host a cornucopia of terrific guests. Mixing it up with Comedians, Authors, musicians, professionals. Nancy Lombardo has performed her unique comedy from coast to coast.  TV credits include The Colin Quinn Show NBC, Saturday Night Live “All my Children” PBS, network and cable television Comedy Tonight, Nickelodeon and the Comedy Channel. She can be seen weekly on The Nancy Lombardo Show channel 56/83/34 NYC and live worldwide on WWW.MNN.ORG. She has written for Penthouse and Cracked magazine and created Ms. Quotable, a comic strip for Lady's Circle Magazine. Nancy was a winner of the Toyota Comedy Festivals "Laughter in Motion” and a Cable Arts Insight Comedy Award." Spot-lighted more than once in *Backstage, as both comedian/writer, she currently indulges her taste for the irreverent in her Stand Up Comedy and show, "Jazz Housewife." Nancy is creator of MOMEDY™, part of the International Mamapalooza Festival. She roasted Vincent Pastore of Soprano fame and is a member of The Friars Club.  Her comedy and music is  available at  www.cdbaby.com/Artist/NancyLombardo Todays feature Artist: Music  by Soce The Elemental Wizard. Andrew Singer www.socetew.com

The human pathogen Helicobacter pylori colonizes half of the global population. Residing at the stomach epithelium, it contributes to the development of diseases like gastritis, duodenal and gastric ulcers, and gastric cancer. It has evolved a range of mechanisms to aid in colonization and persistence, manipulating the host immune response to avoid clearance. A major factor in this is the secreted vacuolating cytotoxin VacA which has a variety of effects on host cells. VacA is endocytosed and forms anion-selective channels in the endosome membrane, causing the compartment to swell. The resulting VacA-containing vacuoles (VCVs) can take up most of the cellular cytoplasm. Even though vacuolation is VacA's most prominent and namesake effect, the purpose of the vacuoles is still unknown. VacA exerts influence on the host immune response in various ways, both pro- and anti- inflammatorily. Most importantly, it disrupts calcium signaling in T-lymphocytes, inhibiting T-cell activation and proliferation and thereby suppressing the host immune response. Furthermore, VacA is transported to mitochondria, where it activates the mitochondrial apoptosis pathway. Within the cell, VacA has only been shown to localize to endocytic compartments/VCVs and mitochondria. Considering its diverse effects, however, the existence of other cellular sites of action seems plausible. In this study, the VCV proteome was comprehensively analyzed for the first time in order to investigate VCV function. To this end, three different strategies for VCV purification from T-cells were devised and tested. Eventually, VCVs were successfully isolated via immunomagnetic separation, using a VacA-specific primary antibody and a secondary antibody coupled to magnetic beads. The purified vacuoles were then measured by mass spectrometry, revealing not only proteins of the endocytic system, but also proteins usually localized in other cellular compartments. This apparent recruitment of proteins involved in all kinds of cellular pathways indicates a central function of VCVs in VacA intoxication effects. In a global evaluation, the VCV proteome exhibited an enrichment of proteins implicated in immune response, cell death, and cellular signaling; all of these are processes that VacA is known to influence. One of the individual proteins contained in the sample was STIM1, a calcium sensor normally residing in the endoplasmic reticulum (ER) that is important in store- operated calcium entry (SOCE). This corroborates the findings of a concurrent report, in which VacA severely influenced SOCE and colocalized with STIM1. A direct interaction of STIM1 with VacA was examined in a pull-down assay, but could be neither shown nor excluded. Immunofluorescence experiments conducted in HeLa cells confirmed the presence of VacA in the ER and also found it to traffic to the Golgi apparatus, identifying these two cellular compartments as novel VacA target structures. The exact route of VacA transport remains unclear, but the involvement of both the ER and the Golgi suggests the possibility of retrograde trafficking, analogous to other bacterial toxins like shiga and cholera toxins. In summary, the elucidation of the VCV proteome and the discovery of the ER and the Golgi apparatus as VacA target structures have generated intriguing starting points for future studies. The detection of many proteins implicated in VacA intoxication effects in the VCV proteome leads to the proposal of VCVs as signaling hubs that may coordinate the complex meshwork of VacA effects. Further investigation of individual proteins is expected to help greatly in illuminating this matter.

More than 50% of the world's population harbor Helicobacter pylori in their stomach mucosa. The chronic gastric infection is associated with several diseases including peptic ulcer disease and gastric carcinoma. One of the most thoroughly studied virulence factors produced by H. pylori is the Vacuolating Cytotoxin A (VacA). All isolated H. pylori strains possess the vacA gene, although significant sequence diversity was noticed in vacA genes across H. pylori isolates. VacA protein is produced and secreted as an 88 kD mature toxin. The protein binds to the host cells and is internalized. Inside the host cells, it causes “vacuole”-like membrane vesicles in the cytoplasm of gastric epithelial cells. Besides vacuolation, VacA exerts various other effects on target cells. VacA also forms membrane-embedded pores at the inner-mitochondrial membrane, resulting in mitochondrial dysfunction by cytochrome c release and apoptosis induction. VacA suppresses nuclear translocation of nuclear factor of activated T-cells (NFAT) resulting in down regulation of interleukin-2 (IL2) gene transcription to efficiently block proliferation of T-cells. The aim of this work was to understand the effects of VacA on intracellular calcium signalling in T-lymphocytes by considering the fact that VacA inhibits the Ca2+-calmodulin-dependent phosphatase calcineurin and induces cell cycle arrest. However, the exact mechanism how VacA exerts this response in T-cells is not known. Therefore, in this thesis various cell lines were used to study the effects of VacA on calcium influx. Calcium influx was found to be affected in the presence of VacA protein in the human Jurkat E6.1 T-cell line and primary human CD4+ T-cells activated by phorbol myristate acetate (PMA). Once inside T-cells, it could be shown that VacA suppresses the increase of the cytosolic free calcium concentration after stimulation by the calcium ionophore ionomycin and thapsigargin. Ionomycin forms pores in the cytoplasmic membrane, whereas thapsigargin blocks the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) and thereby causes depletion of the endoplasmic reticulum (ER) calcium store. In contrast, a VacA mutant, which was constructed by deletion of the hydrophobic region (amino acids 6-27), was unable to induce vacuolation activity and to block Ca2+ influx. A major result of this work was to demonstrate that one of the main components of store operated calcium entry (SOCE), the ER localized calcium sensor protein STIM1, is a target of VacA. Using co-localization studies and yeast two-hybrid (YTH) assays, it was found that VacA localizes to the lumen of the ER where it binds to the cEF-hand domain of STIM1. Furthermore, these data show that VacA strongly reduced the movements of the STIM1 towards the plasma membrane localized calcium channel ORAI1 after Ca2+ store depletion by thapsigargin. A YTH screen identified cEF-hand domain of STIM1 as the target of VacA to inhibit calcium influx. The results obtained in this work showing involvement of VacA in the modulation of intracellular calcium signalling will provide new insights that are required to understand how VacA inhibits T-cell proliferation and signalling.

Soce's musical journey has taken him throughout the world and the genres of hip hop, comedy, dance pop, educational videos and most importantly, having fun. He's interviewed artists alongside legendary producer Prince Paul, won a gay rap battle on Sirius Shade 45 satellite radio and produced the music for the viral hit Date an Asian by Jen Kwok, which has been viewed hundreds of thousands of times on YouTube. http://GreatHipHop.com

Every month, The Sequel Machine recruits 25 writers to write the sequels for film's biggest franchises one page at a time. The catch is, the writers only get to read the page before theirs in a round-robin, exquisite corpse style. The end result is a hilarious, twisted, and as coherent as any misquided Hollywood sequel. This month: Harry Potter 9 3/4. Performed by: Adam Bozarth, Matt Little, Anna Rubanova, Brett White, Kirk Damato, Aaron Jackson, Amy Jackson, Taylor Moore Opening act: Soce, the Elemental Wizard. Follow @soce on Twitter. See the next Sequel Machine show live The Hobbit 4. UCB Theatre East, 3rd Street & Avenue A. Thursday, November 1st, 11:00 PM Written by: Brett White, Brandon Gulya, Kevin Hines, Lauren Hunter, Alan Starzinski, Nate Dern, Silvija Ozols, John Timothy, Nicole Drespel, Chris Scott, Achilles Statalemaky, Pat Baer, Halle Keifer, Adam Bozarth, Kelly Sue DeConnick, Katey Healy-Wurzburg, Dru Johnston,Will Hines, Jeremy Bent, Frank Hejl, Michael Hartney, Jeff Rubin, Kirk Damato, and Matt Little. Script produced by Brett White and Matt Little. Episode sponsored by Audible.com. Get a free audiobook by signing up for a free trial at www.audiblepodcast.com/lefthanded.