Podcasts about h2s

H2S gets the Hollywood treatment, and let's just say reality has some thoughts. The crew tears into how *Landman* portrays one of the oilfield's most dangerous hazards, separating legit risks from TV-level exaggeration based on real-world experience. Along the way, the conversation veers into iconic Billy Bob Thornton one-liners, unhinged family drama, and the kind of business chaos that makes the show wildly entertaining, even when it stretches the truth. Equal parts industry reality check and group chat-style commentary, it's honest, funny, and exactly how people who've actually been around the patch talk about this stuff.Click here to watch a video of this episode.Join the conversation shaping the future of energy.Collide is the community where oil & gas professionals connect, share insights, and solve real-world problems together. No noise. No fluff. Just the discussions that move our industry forward.Apply today at collide.iohttps://twitter.com/nimblephattyhttps://twitter.com/LandmanLifehttps://twitter.com/NewsFinOilhttps://twitter.com/Landmannery00:00 - Intro00:27 - H2S Safety06:32 - Maria Character Analysis06:42 - Ariana Character Insights10:22 - Allie Larter's New House Tour11:33 - Goldman Sachs & Morgan Stanley Loans17:35 - Matt & Warden Discuss Andy Garcia22:10 - The Snow Cone Scene Breakdown23:50 - Rebecca's Plane Ride Experience26:15 - Snakes Only Deal with Snakes Concept28:05 - Demi Moore at Monty's Grave31:10 - Final Thoughts on Episode34:00 - Weekend Wrap-Uphttps://twitter.com/collide_iohttps://www.tiktok.com/@collide.iohttps://www.facebook.com/collide.iohttps://www.instagram.com/collide.iohttps://www.youtube.com/@collide_iohttps://bsky.app/profile/digitalwildcatters.bsky.socialhttps://www.linkedin.com/company/collide-digital-wildcatters

Targa Resources' plan to acquire sour-gas specialist Stakeholder Midstream will give the midstream giant an even stronger foothold in the Northern Delaware Basin, where much of the associated gas has high levels of H2S and CO2.

Bruno Donatini, gastro-entérologue, expert en mycothérapie et formateur en médecine intégrative, revient pour la troisième fois dans un épisode hors-série de Vlan. À chaque échange, Bruno nous livre avec clarté et passion les fondements d'une médecine de précision, à la croisée des savoirs traditionnels et de la science contemporaine. Dans cet épisode plus court que d'habitude, nous avons souhaité aller droit au but : comprendre les quatre grandes typologies de microbiote intestinal et savoir comment les rééquilibrer rapidement.J'ai voulu qu'on simplifie au maximum l'approche, sans perdre la richesse du contenu. Nous passons donc en revue les quatre grands entérotypes : le microbiote appauvri (souvent lié au mode de vie moderne), la flore hydrogène (trop de sucres, souvent chez les jeunes), la flore méthanogène (constipation, transit lent) et la flore de type Prévotella (la plus délétère, avec des risques inflammatoires et tumoraux).Bruno nous guide pas à pas dans l'identification des symptômes (gaz, ballonnements, fatigue, problèmes buccaux…) et les solutions concrètes à mettre en œuvre : ajustements alimentaires ciblés, usage subtil de champignons médicinaux, huiles essentielles bien dosées, drainage du foie, voire stimulation du nerf vague. Il nous rappelle aussi que notre microbiote n'est pas figé, et que nous avons le pouvoir d'agir, à condition d'avoir les bonnes clés.Ce qui m'a frappé, encore une fois, c'est la précision de son approche et sa volonté de redonner aux patients la capacité d'être acteurs de leur santé. Un épisode pour celles et ceux qui veulent comprendre, prévenir, voire inverser des dynamiques profondes de santé.3. Citations marquantes"Votre microbiote, c'est votre avenir de santé entre vos mains.""À 65 ans, on a dix ans d'autonomie devant soi. Voulez-vous les vivre en pleine forme ?""La flore Prévotella, c'est la plus délétère : inflammatoire, virale, tumorale.""Il n'y aura pas de place pour tout le monde. Il faut choisir : prévention ou soumission.""Un bon microbiote, c'est un bon sommeil, une bonne mémoire, et de l'enthousiasme."4. 10 questions structurées posées dans l'interviewQuels sont les grands types de microbiote ?Comment reconnaître la flore hydrogène ?Quelles sont les conséquences d'une flore méthanogène ?Comment se manifeste la flore Prévotella ?Que peut-on faire concrètement pour rééquilibrer son microbiote ?Est-ce que les gaz produits par le microbiote sont toujours odorants ?Quels conseils alimentaires pour réduire la flore hydrogène ?Comment améliorer une flore appauvrie ?Le vieillissement du microbiote est-il réversible ?Quels sont les effets concrets sur la longévité et la qualité de vie ?5. Récapitulatif des timestamps clés pour YouTube00:00 – Introduction : les 4 grands types de microbiote00:54 – Présentation des 4 entérotypes : flore pauvre, hydrogène, méthanogène, Prévotella03:10 – Les gaz : hydrogène, méthane, H2S et leurs conséquences04:08 – Comment diagnostiquer son microbiote cliniquement05:01 – Flore hydrogène : alimentation et traitement05:57 – Flore Prévotella : dangers et protocoles08:55 – Flore méthanogène : traitement et transit09:59 – Flore pauvre : jeunes vs sujets plus âgés12:04 – Syndrome métabolique et flore appauvrie chez les seniors14:34 – Microbiote, immunité et vieillissement16:48 – Âge biologique vs âge réel : les indicateurs de santé19:34 – Prévention, espérance de vie et justice sociale22:08 – Conclusion : le triptyque microbiote – immunité – nerf vague Suggestion d'autres épisodes à écouter : #323 Les selles l'autre baromètre de notre santé avec Bruno Donatini (partie 2) (https://audmns.com/gqTdEmk) #303 Les secrets d'un système digestif en bonne santé avec Bruno Donatini (https://audmns.com/wpAEWJH)Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Ever wondered what really goes into keeping oilfield workers safe? We put an HSE specialist on the spot with all the “dumb” questions, like what happens if there's H2S in the air, or whether bison herds are actually a thing on site. David Valerio from DNOW breaks down safety in plain English, mixing serious insight with plenty of laughs. From OSHA rules and environmental compliance to the realities of working in the freezing North Dakota fields, he explains how safety shapes everything in oil and gas. It's part education, part storytelling, and totally eye-opening for anyone curious about how the industry protects its people and the planet.Click here to watch a video of this episode.Join the conversation shaping the future of energy.Collide is the community where oil & gas professionals connect, share insights, and solve real-world problems together. No noise. No fluff. Just the discussions that move our industry forward.Apply today at collide.ioClick here to view the episode transcript. 00:00 - Intro00:22 - What is HSE (Health, Safety, Environment)05:55 - Day to Day of an HSE Professional09:58 - Long-Term Projects in HSE13:38 - Understanding OSHA Regulations16:40 - Politics in Health and Safety19:37 - Historical Safety Practices22:24 - Safety Culture in Oil & Gas Industry28:47 - Achieving Zero Incidents in Safety30:26 - New Technology and Innovation in Safety33:40 - Environmental Considerations in Energy38:35 - Balancing Pro-Environment and Pro-Energy41:49 - Solutions to Global Energy Problems42:46 - Seeking a Balanced Energy Approach44:37 - Actions You Can Take for Safety47:06 - Future of World Energy Mix55:40 - Net Zero by 2050: Reality or Myth?57:48 - Energy Transition vs. Energy Addition01:03:26 - North Dakota Energy: Oil, Gas, Renewables01:06:33 - Overview of North Dakota Energy Landscape01:11:30 - Winter Challenges in North Dakota01:13:59 - Life in Small Towns01:14:37 - Alma Cook's Contributions01:17:15 - Population Growth vs. North Dakota's Future01:19:05 - Discern Earth: Environmental Insightshttps://twitter.com/collide_iohttps://www.tiktok.com/@collide.iohttps://www.facebook.com/collide.iohttps://www.instagram.com/collide.iohttps://www.youtube.com/@collide_iohttps://bsky.app/profile/digitalwildcatters.bsky.socialhttps://www.linkedin.com/company/collide-digital-wildcatters

While several larger midstream companies were focused on building conventional gas gathering and processing infrastructure in the Southern Delaware Basin, a handful of mostly smaller midstreamers were focusing on the Permian's next challenge: developing systems in the Northern Delaware to gather and treat associated gas with high H2S and CO2 content. In today's RBN blog, we continue our look at the region's sour-gas-related assets with a review of what a few of these companies have assembled.

The midstreamers that built out and/or acquired the sour gas treatment facilities, acid gas injection wells and other assets E&Ps need to exploit the Northern Delaware Basin's crude-oil-saturated rock are sittin' pretty. Put simply, they anticipated what is now a race to “Drill, baby, drill!” in Lea County, NM, where the IP rates for crude are high but so are the H2S and CO2 content in the associated gas. In today's RBN blog, we look at Targa's, Enterprise's and MPLX's sour-gas-related assets.

Could the water you drink impact your gut health? In this episode, Dr. Greg Nigh discusses deuterium-depleted water, sulfur metabolism and hydrogen sulfide SIBO and their relationship with digestion, energy and overall health. You'll also hear practical insights on ketogenic and carnivore diets, plus emerging therapies like peptides and infrared light. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, X, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up your free 30-minute Gut Healing Breakthrough Session. Show Notes

This past week was FILLED with released and teases from the  @BambuLab  H2S going public and mere hours later Bambu showing off, in a video, their Vortek nozzle changer system that many say looks like a  @bondtechab  INDX Clone. THEN a few hours after,  @Prusa3D  joined in the fun teasing a photo with what many have said is INDX on a CORE One, and while we do not TECHNICALLY have any confirmation, we can certainly hope! Lots to talk about!!A HUGE Thank you to the Filament Sponsor of these streams,  @printedsolid ! Check them out: https://printedsolid.comWant to get some of the UK's fastest, and the first REAL Bamboo printer out there? Check out  @construct3d  https://b.link/Construct3D__________________________________Do you have an idea you want to get off the ground? Reach out to the Making Awesome Podcast through https://3DMusketeers.com/podcast and someone will get you set up to be a guest!

We delved into Zach's current project, an educational course on console modification. He plans to make the course engaging but not boring, much like a YouTube video. We also discussed the challenges of creating a course, such as balancing the need for comprehensive information with keeping people's attention. The episode wrapped up with a discussion about the new H2S and H2C 3D printers from Bambu. And we answered a question from a viewer about whether carbon fiber filament can cause splinters.Got a question that you want us to answer? Send us an email at ⁠⁠offthecutpodcast@gmail.com⁠Be sure to hit up the links below to get even more content from us!Interested in starting your own podcast? Check out Streamyard: ⁠⁠⁠⁠⁠https://streamyard.com/pal/c/5926541443858432⁠  ⁠⁠ ⁠-------------------------AftershowConsider supporting the show on Patreon to get access to the aftershow and unlock tons of cool perks!⁠⁠⁠⁠⁠https://www.patreon.com/offthecutpodcast⁠  ⁠⁠⁠-------------------------Hang Out with UsWatch the live stream of the podcast on YouTube!⁠⁠⁠⁠⁠https://www.youtube.com/channel/UCcRJPIp6OaffQtvCZ2AtWWQ⁠⁠⁠⁠⁠-------------------------Pick Up Some Merch!Windbreaker - ⁠⁠⁠⁠⁠https://www.spencleydesignco.com⁠⁠⁠⁠⁠   -------------------------Follow ZacInstagram - ⁠⁠⁠⁠⁠https://www.instagram.com/zacbuilds⁠ YouTube - ⁠⁠⁠⁠⁠https://www.youtube.com/c/@ZacBuilds⁠⁠⁠⁠⁠ TikTok - ⁠⁠⁠⁠⁠https://www.tiktok.com/@zacbuilds⁠⁠⁠⁠  -------------------------Follow EricInstagram - ⁠⁠⁠⁠⁠https://www.instagram.com/spencleydesignco⁠⁠⁠⁠⁠ YouTube - ⁠⁠⁠⁠⁠https://youtube.com/@spencleydesignco⁠⁠⁠⁠ TikTok - ⁠⁠⁠⁠⁠https://www.tiktok.com/@spencleydesignco⁠⁠  ⁠-------------------------Follow Deric@PecanTreeDesign everywhere⁠⁠⁠⁠⁠https://linktr.ee/pecantreedesign⁠⁠⁠⁠⁠ ---------------------------Shoutout to:KM Tools for sponsoring the show! Check out everything they have to offer at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠KMTools.com ⁠⁠⁠kmtools.com/SPENCLEYDESIGNCO⁠ And ⁠WTB Woodworking⁠, our newest sponsor! Check out the giveaway over here:⁠https://www.wtbwoodworking.com/giveaway⁠ #Woodworking #DIY #3DPrinting #Maker #ContentCreation #YouTuber #OffTheCutPodcast

Between @BambuLab releasing v1 of their Farm Software FOR FREE, to new leaks of the H2S, and of course the Games Workshop vs. @GalacticArmory debacle, there is MUCH to talk about this week! And yes, that includes our midnight emergency scan in Florida to help a Vet's office!A HUGE Thank you to the Filament Sponsor of these streams, @printedsolid ! Check them out: https://printedsolid.comWant to get some of the UK's fastest, and the first REAL Bamboo printer out there? Check out @construct3d https://b.link/Construct3D__________________________________Do you have an idea you want to get off the ground? Reach out to the Making Awesome Podcast through https://3DMusketeers.com/podcast and someone will get you set up to be a guest!

Megan chats with Karissa Parrish from Ginger Snaps Baking Affairs about the three powerful blogging strategies she's embracing in 2025 that are moving the needle in her business. Karissa is the food photographer and recipe developer behind the dessert blog, Ginger Snap's Baking Affairs. She started her food blog in early 2020 with the number one goal of providing fellow home bakers with the confidence they need to bake up homemade and tasty desserts in their own kitchens. What started out as a hobby and needing a creative outlet outside of work and every day life has turned into a thriving and continually growing 5 figure business that allows her to stay at home with her son while still working on the blog. In this episode, you'll learn how narrowing your focus, updating existing content, and implementing a smart interlinking strategy can lead to increased traffic and a more aligned blogging business. Key points discussed include: - Content clustering is a powerful strategy: Karissa is narrowing her recipe categories to a handful of focused clusters like cupcakes, cakes, and frostings, helping her increase traffic and efficiency. - Updating old content is non-negotiable: Instead of letting older posts sit stagnant, Karissa revamps them with user-first formatting, stronger H2s, and keyword enhancements. - Interlinking strengthens your blog's structure: Smart interlinking throughout posts (not just at the end!) boosts SEO and helps readers find more value on your site. - Work smarter, not harder: Karissa now creates less new content and focuses more time on refreshing older posts, which is yielding better results in less time. - Let data and joy guide your niche decisions: She recommends blending Google Search Console insights with what genuinely excites you to decide what to focus on. - Build your authority through storytelling: Karissa adds personal background and expertise into blog posts and links back to her About page to build trust and relevance. - Mindset matters just as much as strategy: She reminds us that improving a little each day—even if that means taking a break—is key to long-term blogging success. Connect with Karissa Parrish Website | Instagram

“Visibility in the age of AI isn't just about ranking anymore—it's about being understood, trusted, and retrievable by the machines your buyers now rely on. These engines extract only the most relevant chunks of content to answer the query. And if your message isn't structured clearly or consistent across channels, you risk being invisible.” That's a quote from David Kirkdorffer and a sneak peek at today's episode.Hi there, I'm Kerry Curran, B2B Revenue Growth Executive Advisor, Industry Analyst, and host of Revenue Boost: A Marketing Podcast. Every episode, I sit down with top experts to bring you actionable strategies that drive real results. If you're serious about growth, hit subscribe to stay ahead of your competition.In The New SEO Frontier: How Marketers Can Win Visibility in the Age of AI, I sit down with David Kirkdorffer. He's a B2B marketing strategist and generative SEO expert. We break down how your content, website, and messaging must evolve to be visible in LLM-powered search. We explore what's changed, what still works, and what's next—so your brand stays front and center no matter which AI engine your buyer turns to.Be sure to stay to the end, where David shares why team alignment across content, SEO, PR, and partnerships is your best defense—and greatest opportunity—in an AI-first future. Let's go.Kerry Curran, RBMA (00:01.422)So, welcome, David. Please introduce yourself and share your background and expertise.David Kirkdorffer (00:07.466)Hi, Kerry, and thank you so much for bringing me on the show. My background: I am a B2B marketer. I've been doing B2B marketing for—let's say—30-plus years. I have focused most of my career on generating leads for sales teams, and that is still my focus, though the way that is done nowadays has certainly changed.I've worked mostly in technology companies, selling technology to technology departments—so IT tech for IT tech consumers. Over the years, that has gone from enterprise accounts, as technologies became more democratized, down to medium-sized businesses and small businesses.So that's briefly about me.Kerry Curran, RBMA (01:00.214)Excellent. David, I know you have been deep into the research around what I'll introduce as the evolution of SEO. Tell me: What are you hearing? What triggered your interest in diving into gaining visibility for brands within the GPTs and other AI engines?David Kirkdorffer (01:25.994)Right. OK, that's a great question. Given my background of trying to get information into buyers' hands—being buyer-centric—a number of years ago I focused on what we might call buyer enablement and the buyer experience: the buyer being successful in finding the information they're looking for on our website. I realized that a lot of the great information buyers want sits behind a gate where you have to speak to a sales rep.The idea I was working with—and many people, of course, not just me—was, “Can we get this information onto our website so that when buyers come, they can find what they need and say, ‘This looks like a good fit'?” Along come these LLMs, and now all of a sudden I'm thinking, “How do I AI-enable training? How do I make sure the AIs have the information that answers buyer questions?”In a way, AI LLM tools are a disintermediating force separating my buyer from my answer. They're turning to the ChatGPTs, the Geminis, the Perplexities, the Claudes, the Copilots, and various other tools—some specialized for particular domains. Our challenge is to make sure our answers are read, understood, and correctly represented within these LLMs so that, when a buyer goes there for an answer, our brand is visible.It's much more effective for a buyer to ask questions with ChatGPT, and you might ask the same question to four or five tools just to validate, because they all have different information sets, models, crawlers, and licensing agreements. Therefore, you may have high visibility in one and low visibility in another. Training data differs; retrieval data differs; the models themselves differ—so they have different “brains,” just like different people. That's what brought me into this: trying to be customer-centric and helping my salespeople so that, when buyers do find information, our brand is there.Kerry Curran, RBMA (04:27.744)That's excellent, David, and it's such a hot topic. I don't think I can go through a few hours of my day without it coming up. I know you've been evangelizing it a lot, which I'm sure generates many questions. What are the main questions people ask you about this capability and opportunity?David Kirkdorffer (04:51.442)Everyone wants to know, “What am I supposed to do? How is this different—is it different?” Two main lines of inquiry emerge. One comes from senior marketing leaders—the CMO or someone at a higher level—who wants to understand what they and their teams can do holistically. The other is very tactical: people approach it from their domain expertise—website, SEO, content—and ask, “What do I do within my lane that makes an impact?”The truth is, it's a bit of both. In my view, it's a holistic problem to solve. You can operate in just one tactical lane—website, SEO, or content—and it will have an impact. When you combine them, the impact is amplified, and it should also involve your PR, partner, and demand-gen teams; their work can help or hurt how your brand is recognized and surfaces in answers. So those two lanes—holistic and tactical—intertwine, and where you start depends on team size and resources.Kerry Curran, RBMA (06:48.354)If the main question is “How do I do this?” what do you think people should be asking first? What's the right starting point?David Kirkdorffer (07:01.140)I think you need a big-picture view of how this is different and what drives it—how GEO (Generative Engine Optimization) actually differs from SEO. It even has many acronyms: generative engine optimization, AI optimization, LLM optimization, and more.Kerry Curran, RBMA (07:38.732)Based on your work, which term do you prefer?David Kirkdorffer (07:44.744)I like “generative engine optimization.” Unfortunately, “GEO” means other things in other domains, which is part of the problem—both technically and from a brand standpoint. When we use shortcuts like acronyms, we know what they mean; the LLM doesn't. It could interpret “MRO,” for example, as any of 50 different things until you spell it out first.Kerry Curran, RBMA (08:24.150)Earlier you said it starts with a mindset. What mindset should people adopt to lean into improving their strategies here?David Kirkdorffer (08:46.292)At the highest level, LLMs and GEO replace the short keyword query box with a large window where users add lots of context. Through vectorization—turning language into math—the LLM finds little chunks of information, the “needles,” rather than presenting a haystack of links. It compares those chunks, validates them against other sources, and synthesizes an answer.We often don't know or care where the answer came from, as long as it's accurate. But that means the LLM isn't reading your whole page; it's reading segments. So this isn't just a technical SEO challenge—it's about the words themselves: how we phrase them, how we make them easy to understand, and how we avoid letting brand personality cloud clarity.Because of “chunking,” answers often come from two or three sentences—maybe 200–300 words—not entire pages. So we need to optimize those chunks.Kerry Curran, RBMA (13:06.506)Before we dive deeper into tactics, explain how these platforms differ from Google's traditional search engines and why that demands a different strategy.David Kirkdorffer (13:41.514)Think of GEO as standing on the shoulders of SEO. If your SEO is weak, the shoulders aren't strong. Some say, “This is just a new kind of SEO,” and there's truth in that. Others think, “We just need to do good marketing,” and that's also true. But with GEO, some shortcuts we've taken—like heavy JavaScript or hidden tab content—now have new impacts because LLMs don't execute JavaScript or click tabs.For example, if your page uses tabs for five benefits, the LLM sees only the first one; it can't click the others. It forces us to reevaluate design choices, because GEO cares about different things.Kerry Curran, RBMA (16:11.054)So SEO is shifting from technical crawlability to a content-first approach—almost back to the early days of SEO. When you talk about chunking content, best practices seem to be resurfacing. What should we consider when writing content now?David Kirkdorffer (17:34.914)The best practice is simply doing what we've always known: write clearly for the reader. LLMs struggle with poetic or highly stylized language; they understand literal, structured information. Our challenge is to provide that clarity without becoming too dry. In the future, LLMs may understand nuance better, but for now, literal clarity wins.Kerry Curran, RBMA (21:09.686)There's still a technical aspect—different from technical SEO a few years ago—like tagging. Why is that more important than ever?David Kirkdorffer (21:09.686)We have semantic tags—H1, H2, H3, etc.—but many treat them as visual elements. You might find an H6 above an H2 because it looks good, but that confuses the LLM. Ideally, one H1 states what the page is about, multiple H2s mark subtopics, H3s detail components, and so on. When that hierarchy is broken, the LLM can't map ideas correctly, and your content may be excluded from answers.Kerry Curran, RBMA (25:57.034)Old is new again: off-site SEO also matters. Why is consistency off-site so critical, and what should brands do?David Kirkdorffer (25:57.034)B2B marketers want their message on as many authoritative sites as possible. A small brand's site may have little traffic, so its signal is weak. Getting listed in directories or partner sites amplifies that signal. In the old days, “brand police” ensured consistent boilerplates—25-, 50-, 100-word descriptions—so customers weren't confused. LLMs work the same way: if they see the same wording consistently, they trust it. When every team tweaks the message, it creates variations that confuse the model, so consistency is key.Kerry Curran, RBMA (30:33.718)This has been super valuable. For listeners who know they need to start right away, what's the most important first step?David Kirkdorffer (30:59.392)First, learn how these systems work. You don't need deep technical knowledge, but understand the impact. If you're in a specific lane—SEO, content, web—still learn the bigger picture so your choices align with the new reality. Then triage: audit where you'll work first based on team size and resources.Gather the whole team—web, SEO, content, PR, demand gen—so everyone hears one story and understands how their actions affect each other. Agencies should know what they can and can't do and set expectations. After learning and auditing, remember this is ongoing, like SEO has always been.Finally, be present where your customers go. Different LLMs rely on different data sources—Reddit, Wikipedia, licensed content—and those arrangements change. Go where your customers already spend time.Kerry Curran, RBMA (36:06.339)Excellent. For folks who want to learn more or bring you in to help their team, how can they reach you?David Kirkdorffer (36:42.518)The best way is through LinkedIn. Search “David Kirkdorffer.” My email is firstname.lastname@gmail.com. I post about these topics and provide training classes—very hands-on and tactical, covering tabs, accordions, LLMS text, schema and chunkability, and more. Feel free to DM or email me.Kerry Curran, RBMA (37:52.238)Perfect. I'll include those links in the show notes. David, thank you so much for sharing your expertise with us today.David Kirkdorffer (38:05.046)Thank you, Kerry, and thank you to the audience. If you've made it this far, that's a compliment. I appreciate it and enjoyed the conversation.Kerry Curran, RBMA (38:15.050)Excellent—thanks!Huge thanks to David Kirkdorffer for joining me on the show. If your brand isn't showing up in AI-generated answers, this conversation is your roadmap to change that. From content structure to message consistency to offsite visibility, David laid out actionable ways to adapt your SEO strategy to this new era of AI-driven buyer behavior. If you found this valuable, share it with your team and hit subscribe so you don't miss the next episode.And for more strategic insights on revenue growth through marketing, head to revenuebasedmarketing.com or follow me, Kerry Curran, on LinkedIn today. Flat or slowing revenue? Let's fix that—fast.Revenue Boost: A Marketing Podcast delivers the proven plays, sharp insights, and “steal-this-today” tactics that high-growth teams swear by.Follow / Subscribe on Apple, Spotify, and YouTubeTap ⭐⭐⭐⭐⭐ if the insights move your metrics—every rating fuels more game-changing episodes

⛔️ this ep again mentions suicide.Covering all loose ends from my recollections about working at Amec Foster Wheeler in Kuwait. Finally got to a point where I can move on from #GISchat about Kuwait. Discussed: 0:00 - 3:24 - Emotional impact 3:24 - 3:42 - Agenda3:42 - 22:50 - Use of ChatGPT to interpret arterial blood gas (ABG) test results and fully understand the brutality of the context of the assistant electrician being fired. The system also tells us the consequences in general of H2S gas poisoning.22:50 - 32:56 - Use of ChatGPT to support whistleblowers more generally32:56 - 38:23 Questioning a safety item on p. 37 of the 2016 Amec Foster Wheeler Sustainability Performance Report (https://ungc-production.s3.us-west-2.amazonaws.com/attachments/cop_2017/394131/original/AmecFW_Sustainability_Report_2016_lower_res.pdf?1497623860), 38:23 - 42:36 - Using ChatGPT to help on the North Korean workers angle, leading me to UN Resolution 2397 (http://main.un.org/securitycouncil/en/s/res/2397-%282017%29)42:36 - 50:00 - Use of ChatGPT to support whistleblowers more generally, this section also contains the system's useful summary of all that I have recounted.50:00 - 53:58 - What would be expected to happen _to someone left untreated_ who presented with the particular ABG test results this person had.53:58 - 58:56 - Justice regarding the NBTC Camp 4 building fire and respect for the dead.58:56 - 1:09:21 - Wood PLC compliance officer participation in the cover up and validity of an invitation from a colleague to do a secret investigation,1:09:21 - 1:14:54 - National Crime Agency, invitation to make a police report and plan to do so1:14:54 - 1:18:25 - International Labour Organisation and human trafficking charity (believe it may have been Unseen UK), engaging an investigative journalist1:18:25 - 1:27:41 - Financial Conduct Authority, the stock price since I began whistleblowing and risk for pensioners who depend on these firms being properly policed such that their collapse does not put people's retirement at risk. 1:27:41 - 1:28:50 - Short sellers.1:28:50 - 1:32:50 - Princess Bibi Nasser Al Sabah.1:32:50 - 1:37:32 - Emotional impact and concluding thoughts about responsibilities of the safety staff who made these reports to me.1:37:32 - The Map Maker's Border poem recital.

Kako zmanjšati emisije toplogrednih in kislih plinov kot sta npr. ogljikov dioksid (CO2) in vodikov sulfid (H2S), ena od osrednjih onesnaževalcev v industrijski proizvodnji, in jih znati celo ponovno izkoristiti v proizvodnih linijah? V Reaktorskem centru Podgorica blizu Ljubljane so v okviru evropskega projekta E-CODUCT pretekli teden zagnali pilotni elektrotermični katalitični reaktor z lebdečim slojem, kot so ga poimenovali partnerji projekta, ki ga koordinira Univerza v Ghentu (Belgija). Hkrati z njihovim zmanjšanjem naj bi odpadne pline s procesiranjem v tem reaktorju uporabili za proizvodnjo uporabnih kemikalij kot sta ogljikov monoksid (O) in žveplo (S). Ta pilotni reaktor (TRL 6) so razvili pod vodstvom Centra odličnosti nizkoogljične tehnologije (CO NOT) in Odseka za katalizo in reakcijsko inženirstvo na Kemijskem inštitutu v Ljubljani. Projekt ni pomemben le za naš raziskovalni in industrijski prostor temveč naj bi prispeval tudi k razvoju tehnologij za razogljičenje industrije in k inovacijam. Več o temi v oddaji pojasnita sodelujoča raziskovalca izr.prof.dr. Miha Grilc in dr. Igor Šljapnikov iz CO NOT in Kemijskega inštituta. FOTO: Pred reaktorjem TRL 6 ob zagonu projekta 8.aprila stojijo z leve, Miha Grilc, Joris Thybaut (Uni v Ghentu), Miran Gaberšček in Igor Šljapnikov VIR: Goran Tenze, Program Ars

Here we look at a missed opportunity to avoid the death of 49 people in an NBTC accommodation fire last year in Mangaf, Kuwait. The missed opportunity was in the firing of a worker in 2017 for calling an ambulance in response to an H2S gas poisoning at GC-30 in the North Kuwait Asset. Instead, he could have been listened to for stating that people are punished for speaking up about safety issues. NBTC, Amec Foster Wheeler, Petrofac and the Kuwait Oil Company could then have changed their safety practices. One is invited to wonder if the building fire killing 49 people 7 years later in 2024 would not have occurred if this change had occurred.We will have one more episode on Kuwait, then move on to Qatar and London, UK.

L'art de reconnaître la réduction dans le vin ------------------------ Vous ouvrez une belle bouteille, et … une odeur désagréable s'échappe de votre verre. Allumette, œuf pourri, chou cuit ou même caoutchouc brûlé ? Il s'agit vraisemblablement de réduction. Voilà ce que vous devez retenir à ce sujet ! Qu'est-ce que la réduction ? Pour simplifier, elle survient souvent lorsque le vin est dans un milieu fermé, comme pendant l'élevage ou en bouteille. Ce phénomène crée des arômes particuliers, qui résultent de la combinaison de l'absence d'oxygène et de la présence de composés soufrés. Quels arômes reconnaître ? Au 1ers stades : Allumette, ...(Composé responsable : le dioxyde de soufre, ou SO2) Par la suite: Œuf pourri, chou, caoutchouc brûlé, marais.( Composé responsable : le sulfure d'hydrogène ou H2S, voire mercaptan). Que faire face à un vin réduit ? Faites tourner le vin dans le verre pour l'oxygéner. Utilisez une carafe large pour aérer encore plus le vin. Cette oxygénation peut constituer une solution, si la réduction n'est pas assimilée à un défaut. Au-dessus d'un certain seuil, il n'y a malheureusement rien à faire, et le vin n'aura d'autre destin que de finir dans l'évier Tout cela, je vous en parle en détail dans cette leçon vidéo "Voilà comment reconnaître la RÉDUCTION dans le vin", à retrouver sur ma chaine : A bientôt ! Recevez votre kit du dégustateur : https://www.lecoam.eu/kit

Sintana Energy CEO Robert Bose recently spoke with Steve Darling from Proactive to provide an update on the company's second exploration campaign in Namibia's Orange Basin. The campaign is focused on Blocks 2813A and 2814B, governed by Petroleum Exploration License 83 (PEL 83), which is operated by Galp Energia. Sintana indirectly holds a 49% interest in Custos Energy, which maintains a 10% working interest in PEL 83, alongside NAMCOR's 10% stake. The PEL 83 Joint Venture recently announced a significant milestone: the successful drilling and logging of the Mopane-2A well (Well #4), which spud on December 2. The exploration revealed hydrocarbons in two reservoirs: a gas-condensate column in AVO-3, characterized by thin net pay within its sweet spot, and a light oil column in AVO-4. Bose highlighted the reservoirs' promising characteristics, including high-quality sands with excellent porosity, permeability, pressure, and fluid properties. Additionally, the reservoirs exhibited minimal CO2 content and no H2S or water contacts, further underscoring their quality. The data collected from Mopane-2A is now under analysis to deepen the understanding of the Mopane complex and evaluate its commercial viability. Meanwhile, the drillship has relocated to the Mopane-3X exploration well (Well #5) site, where drilling is set to target two stacked prospects, AVO-10 and AVO-13. Spudding for this well is scheduled for early January. This progress reflects Sintana Energy's commitment to advancing its exploration initiatives in one of the world's most promising emerging hydrocarbon basins. #proactiveinvestors #sintanaenergyinc #tsxv #sei #otcqb #seusf #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews #OilExploration #Namibia #OrangeBasin #EnergySector #PEL83 #RobertBose #GalpEnergia #Chevron #QatarEnergy #EnergyNews #ProactiveInvestors #2025EnergyTrends #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

Send us a message with this link, we would love to hear from you. Standard message rates may apply.This episode explores the science behind flatulence odor and introduces a simple, over-the-counter remedy: Pepto-Bismol. The episode explains that the unpleasant odor associated with flatulence is primarily caused by hydrogen sulfide (H2S), a gas produced in the colon during the breakdown of food. Pepto-Bismol, or bismuth subsalicylate, works by binding to hydrogen sulfide in the colon and reducing the amount of gas released. The episode highlights a study published in Gastroenterology which found that bismuth subsalicylate significantly reduced H2S release in human fecal samples. Participants in the study experienced a greater than 95% reduction in fecal H2S release after taking Pepto-Bismol for 3-7 days. The episode also emphasizes the importance of consulting a doctor before using Pepto-Bismol, especially for those with medical conditions or taking other medications.Support the showProduction and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

Norman is a versatile Geologic Consultant with 15+ years of success in exploration, development, and petroleum geology. History of success in on-site support, drilling strategy optimization, and team mentorship. Expertise in wireline log interpretation, H2S risk management, and thorough well-logging in diverse basins worldwide. Skilled in productivity assessments, geologic modeling, and data accuracy, driving impactful contributions to production and exploration projects. Adept at instructing, leading, and mentoring new team members, elevating their expertise and professional development. Leverage advanced knowledge in petroleum production estimation software, enabling precise petrophysical analysis, reservoir characterization, and forward-thinking production forecasting.

Technical Tips for When Things Go Wrong with Cider Making This episode features two cider professionals and a cider industry consultant, which is exactly who you need a direct line to when your cider has problems. Hear from Megan Faschoway who at the time of this recording was Senior Cider Maker at Sea Cider, Kira Bassingthwaighte Head Cider Maker at Western Cider in Montana and Nick Gunn of BenchGraft a cider consultation service based in Salem Oregon. This talk took place in Portland Oregon at CiderCon, the annual cider conference hosted by the American Cider Association. The title of the talk was “What to do when things go wrong”. The focus was not on preventive measures, but as the title says – curative steps that one can take to try to mitigate a problem with a particular cider In this Cider Chat on Cider Problems Dealing with rotten egg smell from your cider Hydrogen sulfide (H2S) is a negative off-aroma compound that can occur in cider and has a rotten egg smell. It's produced by the yeast Saccharomyces cerevisiae during cider fermentation. Filtering cider Using Reverse Osmosis (RO) Tasting Panels for feedback Dealing with a saturated cider maker's palate Saving samples from each batch to create a library for potential cider problems down the road Contact for Speakers on this Panel Kira Bassingthwaighte, Western Cider Hear Kira on Episode 295 Megan Faschoway Nick Gunn BenchGraft Hear Nick and Dave White of Whitewood Cider on Episode 004 Mentions in this Cider Chat French Cider Tour September 2024 Oliver's Cider and Perry Company – UK Cider in Herefordshire, Tom Oliver audio clip The Whose Who of #xpromotecider in this episode? Join the fun and download the info flyer on Cider Chat offerings at the Support Page! Post, share and social media and tag Cider Chat! Cider's XPromoters will be featured on an end of year episode!   De Gerdenner Cider, Netherland Northwest Cider Association reposted Episode 410 with Olympic Bluffs Cider and Lavender Farm Ross on Wye Cider and Perry Company posted last week's Episode 410 Perry Panel Dragon' Head Cider Camra Cider and Perry American Cider Association – CiderCon

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Newly launched Humane Slaughter Initiative webpage, published by Léa Guttmann on March 29, 2024 on The Effective Altruism Forum. This post was cross-posted by the Forum team with the permission of the author. The author may not see or respond to comments on this post. Greetings from Shrimp Welfare Project! Our team is excited to announce the launch of our new webpage dedicated to the Humane Slaughter Initiative! This initiative aims to revolutionise the way shrimps are stunned prior to slaughter and pave the way for the future of ethical shrimp production. Learn more about this new page below. In a newly published article on our website highlighting the urgency of responsible pond management, findings revealed alarmingly toxic hydrogen sulphide levels in shrimp ponds in India's Serepalem village, prompting a successful sludge removal intervention that significantly improved conditions - underscoring the imperative of sustainable practices for shrimp welfare and farm productivity. Tamar Stelling wrote a piece for De Correspondent in the Netherlands, highlighting our corporate engagement work with a focus on electrical stunning. It is a mix of in-depth shrimp welfare discussion, some recognition where it is due (e.g. Albert Heijn), and a lot of fun! Have a great week! Léa | SWP Communications Lead The Humane Slaughter Initiative webpage SWP is thrilled to announce the launch of our Humane Slaughter Initiative webpage! What's the initiative about? Until the end of 2025, SWP is providing ~24 shrimp producers with free electrical stunners on the condition they use it to stun a minimum of 1,500-2,000 metric tons of shrimp per year. The goal is to accelerate industry adoption of this more humane stunning method ahead of expected buyer demands and regulations. Why is it impactful? Scientific literature establishes shrimp sentience. In addition, consumer demand for higher welfare standards is increasing globally. Electrical stunning is also recognised as the most humane pre-slaughter method currently available for shrimps. It renders shrimp unconscious faster and more effectively than ice slurry immersion or asphyxia. Leading retailers like M&S and John Lewis Partnership have already committed to using electrical stunning, setting the stage for industry-wide adoption. What will you find on the page? This page serves as your go-to resource for our initiative, offering an in-depth overview, a breakdown of how Ace Aquatec and Optimar equipment function, and a summary of the eligibility requirements. Any questions? Our FAQ section may have your answers. Ready to apply? Fill out the application form you will find on the page. Tackling Hydrogen Sulphide levels in shrimp farms In a recently published article, Shrimp Welfare Project conducted a crucial study in the village of Serepalem, Andhra Pradesh, India, which found alarming findings of toxic levels of hydrogen sulphide (H2S) in all 38 tested ponds. This poses a severe respiratory toxin for shrimps. As an intervention, SWP facilitated sludge removal in a pond with 10 years of build-up, leading to a significant drop in H2S from hazardous to near-threshold levels. This small but impactful study underscores the importance of regular pond maintenance through cost-effective sludge removal to improve shrimp welfare and farm productivity. Moving forward, SWP plans to expand this sustainable intervention to other neglected areas. Dive Deeper If you want to learn more about shrimp welfare and the shrimp farming industry: SWP's pioneering efforts in advancing shrimp welfare, particularly through the Humane Slaughter Initiative, have gained recognition in a recent Global Seafood Alliance article, alongside advocacy by prominent retailers like Marks and Spencer, Waitrose & Partners, and Albert Heijn. The article showcases SWP's provision of...

Explore the often overlooked diagnosis of hydrogen sulfide SIBO (small intestine bacterial overgrowth) and its diverse array of symptoms, including food intolerances, inflammation, diarrhea and abdominal pain, shedding light on its association with conditions like IBD, colorectal cancer and Parkinson's Disease. Gain invaluable insights into testing, treatment and dietary adjustments crucial for managing hydrogen sulfide SIBO and reclaiming gut health. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

There are many manhole rehabilitation and lining solutions in the market today designed to resolve various sanitary sewer collection system problems. Most are designed for H2S protection, some focus on strength, however few are formulated with a balance to specifically abate inflow and infiltration (I/I) while also protecting against corrosion. Let's explore the many types of applied liners used in manhole rehabilitation, including cementitious products, ultra-high build epoxies, polyurethanes, and polyureas. Each of these technologies have their strengths and weaknesses.

#291 Dr. Goldenberg is passionate about how we evaluate and utilize evidence. He is an active researcher with numerous publications in high-impact scientific journals such as JAMA and the BMJ and is an Associate Research Investigator at the Helfgott Research Institute. He is faculty for the Academy of Integrative Health and Medicine and the Helfgott Research Institute where he teaches critical evaluation of the medical literature and advanced evidence synthesis. His love for teaching integrative evidence-based medicine led him to found the DrJourncalClub website and Podcast. He received his Doctorate in Naturopathic Medicine from Bastyr University and his Bachelor's in Molecular Biology with honors from the University of Pennsylvania. He is a past  President of the Gastroenterology Association of Naturopathic Physicians and a Fellow of the American Board of Naturopathic Gastroenterology. His clinical focus is on integrative approaches to gastroenterology conditions with a special focus on small intestinal bacterial overgrowth. He sees patients virtually at the Goldenberg GI Center. His interest in evidence has taken him from clinic to courtroom, recently co-founding three businesses focusing on brain injury litigation and forensic epidemiology. In this episode we cover What is hydrogen sulfide and what is its function in the body When does hydrogen sulfide  become a problem and what may one experience if they have H2S overgrowth Joshua's insight from his current research on Hydrogen Sulphide SIBO How is Joshua currently testing for it? He sheds light on the new at-home handheld devices for SIBO testing Treatment strategies for Hydrogen sulphide SIBO And so much more

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, “Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome.” Hutchinson-Gilford progeria syndrome (HGPS) is a rare human disease characterized by accelerated biological aging. Current treatments are limited, and most patients die before 15 years of age. Hydrogen sulfide (H2S) is an important gaseous signaling molecule that is central to multiple cellular homeostasis mechanisms. Dysregulation of tissue H2S levels is thought to contribute to an aging phenotype in many tissues across animal models. Whether H2S is altered in HGPS is unknown. In a new study, researchers Stephen E. Wilkie, Diana E. Marcu, Roderick N. Carter, Nicholas M. Morton, Susana Gonzalo, and Colin Selman from the University of Glasgow, University of Edinburgh, Saint Louis University, and Karolinska Institute investigated hepatic H2S production capacity and transcript, protein and enzymatic activity of proteins that regulate hepatic H2S production and disposal in a mouse model of HGPS (G609G mice, mutated Lmna gene equivalent to a causative mutation in HGPS patients). “This study was designed and undertaken due to the lack of understanding in the mechanistic targets of known treatments against HGPS and considering the positive association between H2S and longevity in model organisms.” Here, the researchers employed the HGPS mouse model G609G to test the hypothesis that, in contrast to anti-aging increases in H2S production, the accelerated aging typical of progeroid mice is associated with reduced hepatic H2S production. G609G mice were maintained on either regular chow (RC) or high fat diet (HFD). HFD has been previously shown to significantly extend lifespan of G609G mice, and compared to wild type (WT) mice maintained on RC. RC-fed G609G mice had significantly reduced hepatic H2S production capacity relative to WT mice, with a compensatory elevation in mRNA transcripts associated with several H2S production enzymes, including cystathionine-γ-lyase (CSE). H2S levels and CSE protein were partially rescued in HFD fed G609G mice. The data acquired here confirmed some aspects of the relevance of H2S in HGPS but raises more questions about the specific mechanisms at play. “Regardless, the work presented here addresses an area of research that remains critically understudied and provides new evidence that the accelerated ageing phenotype observed in HGPS may be partially explained by a reduction in hepatic H2S levels.” DOI - https://doi.org/10.18632/aging.204835 Corresponding authors - Colin Selman - colin.selman@glasgow.ac.uk, and Stephen E. Wilkie - stephen.wilkie@ki.se Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204835 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, progeria, hydrogen sulfide, high-fat diet, ageing, lamin A About Aging-US: Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at www.Aging-US.com​​ and connect with us on social media. MEDIA@IMPACTJOURNALS.COM

In this episode Sheldon speaks with Master Hydrogen Sulfide Trainer Stan Smiley. In this conversation, Sheldon and Mr. Smiley speak about the hidden dangers on Hydrogen Sulfide (H2S), H2S training and detergent suicide. Don't miss this revealing episode.

“You need to know all extraneous variables affecting your audience's pain point and use the LEMA framework to build content around that.”Lily introduces us to the LEMA Framework, which stands for Logic, Explicitness, Memorability, and Actionability. She explains that remarkable content needs to engage readers, be clear and explicit, leave a lasting impression, and provide actionable steps for the audience.Throughout the episode, Lily provides insights on how to apply the LEMA Framework to content creation. She highlights the importance of defining the search intent and target audience, crafting headings and subheadings that address the readers' knowledge level, and creating a thesis with novel ideas. Lily also emphasizes the significance of providing clear actions, breaking down complex information into digestible pieces, and using visuals to enhance understanding.Tune in to discover how to use the LEMA Framework to create content that captures your audience's attention and delivers value!In this episode, we talk about:Content strategyLema frameworktarget audienceTimestamps:[00:05] Introduction[01:20] Exploring the LEMA Framework: Logic, Explicitness, Memorability, and Actionability[06:37] Coined concepts, novelty, and relatability[09:45] Analyzing a blog post breakdown and defining search intent[15:00] Understanding the audience's needs and goals[17:17] Creating an outline tailored to audience interests[19:34] Crafting clear and specific H2s[24:50] Applying the LEMA Framework and tailoring content to different audiences[27:20] Wrap UpAbout Lily UgbajaLily Ugbaja is a Content Marketing Consultant who's helped brands like WordPress, Hubspot, and Zapier win more of their best buyers with content. She runs 3 blogs of her own and previously worked as a Content Marketing Manager at Animalz helping brands like SimpleLegal grow traffic by over 500%.Connect with Lily Ugbaja on LinkedIn: https://www.linkedin.com/in/lilyugbaja/  Join the Flying CatsStill feeling your stomach drop whenever you have to report organic growth to leadership? Things are about to change

What the heck is molecular hydrogen? Isn't it the same as hydrogen? Although it's not talked about in Western medicine circles, and the research is early, there are 2000+ scientific studies including over 100 clinical studies suggesting that H2 has therapeutic potential in over 170 different human and animal disease models, and in essentially every organ of the human body.H2 reduces oxidative stress and improves redox homeostasis partly mediated via the Nrf2 pathway, which regulates levels of glutathione, superoxide dismutase, catalase, etc.H2, like other gaseous-signaling molecules (e.g. NO•, CO, H2S), modulates signal transduction, protein phosphorylation, and gene expression, which provides anti-inflammatory, anti-allergy, and anti-apoptotic protective effectsMy guest today, Greg "The Hydrogen Man" talks about his personal experience using molecular hydrogen to save his health, and how he's helped others in terrible health like his father, who suffered from arthritis, glaucoma, and more. Hydrogen has also been shown to be extremely protective of the heart. In fact, in Japan, it's standard protocol to put those suffering from strokes on a molecular hydrogen machine. There are also several studies showing its positive effects during the pandemic for those suffering from pulmonary issues. If you're interested in grabbing the molecular hydrogen machine Greg talks about head over to Holy Hydrogen and use the code "JOELEVAN" for a discount.Additional ResourcesBenefits of HydrogenIntro OneStory Behind the MachineResearch

After doing this podcast I realised there is one huge thing people are not taking ownership of but absolutely should be – air quality. Think about it, we worry about our diet, but only eat a few times a day. We worry about exercising, but that's maybe an hour a day. But we breathe every second of every day, and what if what we are breathing is full of aggravating and inflammatory toxins?! David Millburn is the chief technology officer of Hypoair, a leading player in the air filtering space for over 15 years. Their proprietary technology is used from small homes to massive buildings. All their technology is backed by a huge amount of science, and uses cutting edge technology that creates proven and innovative results. Their tests are available upon request, and cover topics including VOCs, MERS, Molds, MRSA, O3, TBC, HCHO, RSP, NH3, H2S, and much more.Check out Hypoair's products at Made To Thrive and because you're a loyal listener, receive 10% off any of their amazing air cleaning products:https://madetothrive.co.za/special-deals/hypoair/Join us as we explore:Everything air quality – why it is so important for your health, the pollutants and toxins that are around us every day like molds, bacteria and viruses, the abundance of chemicals we think improve air quality but only make it worse, and why the air quality in your home is definitely worse than the air outside.The dynamic nature of air quality - how it changes throughout the day, how it depends on your unique geography, on your neighbors and easy tips you can try today to assess the air quality around you.The Hypoair technology, which product would be right for you and your home, Hypoair's philosophy of addressing each area of your home individually and why their devices were the first globally tested on their impact on COVID19.Why air quality extends beyond your home! What are the pollutants in your car? In the hotel rooms you travel to? And why Hypoair's mobile technology is your air quality game changer.Mentions:Website – Breezometer, https://breezometer.comSupport the showSupport the show on Patreon:As much as we love doing it, there are costs involved and any contribution will allow us to keep going and keep finding the best guests in the world to share their health expertise with you. I'd be grateful and feel so blessed by your support: https://www.patreon.com/MadeToThriveShowSend me a WhatsApp to +27 64 871 0308. Disclaimer: Please see the link for our disclaimer policy for all of our content: https://madetothrive.co.za/terms-and-conditions-and-privacy-policy/

Not only is the cider acclaimed, so too is the Maker Tom Oliver is just as acclaimed as his cider which makes Oliver's Cider and Perry Co. a global hit on two fronts. He is affable, engaging and knows his way around social media likely due to his work with the Scottish Rock Rock Band, The Proclaimers. Cidermakers are not well known for reposting news stories about themselves and their product, but Tom is a master of this one simple act that keeps Oliver's in the news and endears him to media. That singular step alone is just one of many giveaways that Tom provides to the slow moving cider industry. This topic is key for makers looking to up level their online presence, but it was not the topic of conversation in this episode. Instead Ria and Tom caught up after the world shut down for the past 2 plus years at CiderCon 2023 held in Chicago. In this chat How minimal intervention is key for Oliver's Cider and Perry What is Farmhouse cider Spontaneously fermented - wild yeast Tannic cider and Perry Pears At Oliver's there is no measuring of sugar or fiddling with the cider. In fact, Tom can be heard in most interviews saying "Don't fiddle with cider." What's new for this acclaimed makers and cidery? More c0-ferments and collaborations! Bâtonnage This is a technique used by winemakers, where the lees (yeast cells) are stirred into solution. Nano proteins are the biggest benefit of Bâtonnage They release into the cider providing a perception of sweetness and body with out the sugar Need at least 9 months to a year to get the nano proteins There are short term benefits. Yeast produces less carbon dioxide and bubbles. They slow down after the first primary ferment. Fermentation may have stopped but there is still sugar left. Lees absorb off aromas, except for H2S rotting egg smell. Bâtonnage helps to maintain a reductive state. Full reduction - rotting smell is a type of reduction. Which helps protect the cider from oxidization and protect the flavor components. Find out more about Bâtonnage by going to Episode 233: Ask Ryan Quarantine Quad Series where Ryan Monkman of Fieldbird Cider in Prince Edward County Canada provides an in depth overview of Bâtonnage and Maderisation (where the barrels are cooked). Contact info for Oliver's Cider and Perry Company Website: https://www.oliversciderandperry.co.uk/ Mentions in this chat Send your questions to info@ciderchat.com about fermentation and yeast for an upcoming Q&A with Fermentis - Yeast and Fermentation Solutions for Cidermakers Subscribe to eCiderNews

Google's very own Martin Splitt joined me on the SEJ Show to share his thoughts and opinions on various technical SEO topics, such as Semantic HTML, Google Search Console, indexing, and client-side rendering. Explore how to leverage these powerful tools to improve your website's SEO. Prefer to watch the video? Register here: http://bit.ly/3YQxzG7  I would say make sure that you are focusing on the content quality and that you are focusing on delivering value to your users. Those have been, will always be, and are the most important things. Everything else should follow from that. –Martin Splitt Suppose you are fine-tuning technical details or your website's structure or markup. In that case, you are likely missing out on the more significant opportunities of asking yourself what people need from your website. –Martin Splitt This question keeps coming up. This is not the first time and will not be the last time this question will come up and continue to be asked. I don't know why everyone thinks about who, what value, or who. It's about structure. I can't emphasize this enough, if you choose to have H1s as your top-level structure of the content, that's fine. It just means that the top level of the content is structured along the H1s. –Martin Splitt   [00:00] - About Martin [02:47] - Why Semantic SEO is important. [04:22] - Is there anything that can be done within Semantic HTML to better communicate with Google? [06:02] - Should schema markup information match what's in the document? [08:24] - What parts of Semantic search does Google need the most help with? [09:19] - What is Martin's opinion on header tags? [14:22] - Is the responsibility of implementing Semantic HTML on the SEO or the developer? [16:19] - How accessible is Semantic HTML within a WordPress, or Gutenberg-style  environment?  [19:58] - How compatible is Semantic HTML with WCAG? [21:08] - What is the relationship of Semantic HTML to the overall concept of the Semantic web RDF, etc.? [25:04] - Can the wrong thumbnails be rectified utilizing Semantic HTML? [28:42] - Is there another type of schema markup that can still refer to the organization and use IDs on article pages? [32:10] - Can adding schema markup to show the product category hierarchy and modifying HTML help Google understand the relationship between the product and its category? [33:49] - Is preserving header hierarchy more critical than which header you use? [36:36] - Is it bad practice to display different content on pages to returning users versus new users? [40:08] - What are the best practices for error handling with SPAs? [45:31] - What is the best way to deal with search query parameters being indexed in Google?  [48:02] - Should you be worried about product pages not being included within the XML site map? [50:26] - How does Google prioritize headers? [56:00] - How important is it for developers and SEOs to start implementing Semantic HTML now? [57:31] - What should SEO & developers be focusing on?   If you understand that it's a 404, you have two options because two things can happen that you don't want to happen. One is an error page that gets indexed and appears in search results where it shouldn't. The other thing is that you are creating 404s in the search console and probably muddling with your data. –Martin Splitt If you have one H1 and nothing else under it except for H2s and then content H2 and then content H2, that doesn't change anything. That means you structured your content differently. You didn't structure it better. You didn't structure it worse. You just structured it differently. –Martin Splitt   For more content like this, subscribe to our YouTube channel: https://www.youtube.com/user/searchenginejournal  Are you looking to keep up with current and effective digital marketing today? Check out https://www.searchenginejournal.com  for everything you need to know within the digital marketing space and improve your skills as an internet marketer. Connect With Martin Splitt: Martin Splitt - the friendly internet fairy and code magician! He's a tech wizard from Zurich that has magic fingers when it comes to writing web-friendly code.  With over ten years' experience as a software engineer, he now works as a developer advocate for Google. A master of all things open source, his mission is to make your content visible in any corner of cyberspace - abracadabra! Connect with Martin on LinkedIn: https://www.linkedin.com/in/martinsplitt/ Follow him on Twitter: https://twitter.com/g33konaut   Connect with Loren Baker, Founder of Search Engine Journal: Follow him on Twitter: https://www.twitter.com/lorenbaker   Connect with him on LinkedIn: https://www.linkedin.com/in/lorenbaker  

Welcome to part 2 of our SEO dictionary  episode where we cover 10 more common SEO terms!Share us with a friend!1.  SEO terms discussed today include alt text, domain authority/rank, headings (H1s and H2s), 301 redirects, and more.Alt text is used to describe images for accessibility purposes. URL stands for Uniform Resource LocatorsDomain Authority measures how trustworthy a website is.Headings are where keywords should be strategically placed to optimize SEO.Canonical URLs designate one page you want Google to index while similar pages won't be indexed.A 301 Redirect allows an outdated page URL to go somewhere else instead of being broken2.  Fun facts about how the internet works: Bots are behind the scenes, indexing and crawling to help gather and analyze information.Amazon owns most of the online real estate due to its serves, making money through web services.Anchor texts should relate specifically to the link they are connected to ... try to avoid generic phrases like "click here."3.  Organic search is becoming more popular as a result of new search engines such as you.com, which does not rely on ads for its results.UnNoticed Entrepreneur - step into the spotlight.Entrepreneurs share their secrets to getting noticed in 20 minutes.Listen on: Apple Podcasts SpotifyIf you're looking for a unique, handcrafted way to spruce up your home or office, then Collage and Wood is the perfect place for you! We offer a range of beautiful wooden signs that are perfect for any occasion. Our talented team of artists will work with you to create a sign that perfectly suits your needs. So why wait? Visit Collage and Wood today!Support the showListen to the private podcast for just $10/mo: SEO Shorts helps you put a simple & *strong* SEO strategy in place, today!Be our (podcast) guest! Apply hereB's SEO Basics Checklistbrittanyherzberg.com / Instagram 10,000 Jasper words FREE!crystalwaddell.comGet the Show merch!

In this episode, Sheldon continues the conversation with Certified H2S Master Instructor, Stan Smiley. Stan gives stories of his time in oil and gas, emergency response, and case studies related to H2S exposure. If you are exposed to hydrogen sulfide, then this is a must listen episode for understanding this common hazard.

Happy New Year! It's 2023 and Sheldon starts the year off with a important interview with H2S Certified Master Trainer, Stan Smiley. Mr. Smiley is one of a rare group of safety educators that bear the distinction of excellence in this by being designated as a Hydrogen Sulfide (H2S) Master Instructor®, numbering less than 123 worldwide and of those, one of 41 currently certified. Primus Global Media will host a H2S Instructor Development Course this February 15-17, 2023. For more information: primus.training

1. YouTube #golivetogether Feature Update - YouTube has announced that it's opening up its ‘Go Live Together (#golivetogether)' option to more users from next week, which will provide more creative considerations for your live-streams in the app.Go Live Together enables you to invite another YouTube user to your stream, with the video then displayed in vertical split-screen, providing new engagement and interaction options during a YouTube live broadcast. That could open up new opportunities for brands to run live interviews or internal spotlight sessions on their YouTube channel, while also facilitating Q and A sessions and other options to build engagement among your YouTube community. Hosts will be able to rotate the guest on their live-stream, but only one guest at a time will be able to take part in the broadcast.YouTube will also allow pre-roll, mid-roll, and post-roll ads on Go Live Together streams, which will be attributed to the host channel of the broadcast. YouTube says that all channels with at least 50 subscribers will soon be able to launch Live Together streams, with the roll-out beginning next week – though YouTube does note that it may take a few weeks to become available to all users.2. Instagram Subscriptions - Launched as a limited test back in January, subscriptions on Instagram are now available to all eligible US creators. Subscriptions allow creators to offer exclusive content in exchange for a recurring monthly payment from their followers. To see if you're eligible for Instagram Subscriptions, open the Instagram app and go to your professional dashboard. If you're eligible, you'll see an option to set up subscriptions for your account. With this feature activated, you can start posting subscriber-only: Live Streams  Stories  Badges  Posts  Reels  Group chats  Broadcast channels You can promote subscriptions in your Instagram stories with a dedicated sticker. When users tap on the sticker, they're taken to the subscription page. In addition to exclusive content, subscribers also get a special badge next to their name when commenting on posts.3. Facebook Professional Profile Is Now Available To All Users - Facebook's professional profile mode is now available to users worldwide, allowing everyone to showcase their skills and abilities. Facebook's “Professional Mode” is a profile setting that removes the need to create a Facebook Page to get your content in front of a larger audience. Also, you can now earn money from your Reels, or by enabling ads before, during, and after longer videos. Lastly, you can allow your fans to increase their support for you with a monthly subscription and share subscriber-only content. To learn more about Professional profile, click here.4. New UET Tag Dashboard In Microsoft Clarity - Understanding both user behavior and customer journey is crucial for successful marketing. To empower you with richer insights in a seamless experience, Microsoft launched Microsoft Clarity offering insights for Microsoft Advertising on Oct 18, 2021.  In hindsight, this is something I should have covered in Episode#79 and now regret skipping over the launch announcement.Anyways, Microsoft Clarity helps you better understand post-click user behavior and engagement on your landing pages because it's powered by the Universal Event Tracking (UET) tag that you place across your website. Now there's also a new UET tag dashboard which can help you monitor tag data and fix any issues that arise. This is a one-stop shop for all things UET, including real-time insights into the data that gets sent via UET tags and troubleshooting action recommendations.5. Microsoft Rolls Out Import Tool For Google Ads Performance Max - To simplify duplicating your efforts across platforms when using Google Ad's Performance Max campaigns, Microsoft Advertising has rolled out an update in their Google Import tool that allows advertisers to duplicate their Google Ads Performance Max campaigns.  Currently they only support Performance Max campaigns that use a Merchant center and will import the campaigns as Smart Shopping Campaigns and Local Inventory Ads. They have also started a pilot solution for importing your other Performance Max campaigns that aren't using the Merchant Center, starting with an experience that will import these campaigns as Search campaigns and create Dynamic Search Ads (DSA).Click here to learn more about on how to import your Performance Max campaigns in to Microsoft.6. Microsoft Ads Expands Availability Of ‘Similar Audiences' - If you're looking to expand your reach and find new potential customers, Similar Audiences automatically find new customers for you by looking for people who are similar to those in your remarketing lists. These audiences are generated automatically by Microsoft Advertising once you have a remarketing list in place. Similar Audiences can be used in the US and Canada, and the great news is that they're now generally available in more markets 7. Similar Audiences Is Going Away In Google Ads - Starting May 1, 2023, Google Ads will no longer generate similar audiences (also referred to as “similar segments”) for targeting and reporting. If you have active campaigns with similar segments, those will remain with your campaigns until August 1, 2023. After August 1, similar segments will be removed from all ad groups and campaigns. You'll continue to have access to historical reporting for similar segments from past campaigns. According to Google, In place of similar segments, different campaign types will offer different solutions to help you leverage your first-party data, reach the right audience, and improve campaign performance so that you can optimize directly for your business goals.If you have been using similar segments on Display, Discovery, or Video Action campaigns, and haven't yet turned on optimized targeting, you should turn on optimized targeting to reach additional relevant and expanded audiences and optimize for your conversion goals.If you have been using similar segments on Awareness and Reach video or Consideration video campaigns, you should include your first-party data segments in your ad groups, and turn on audience expansion to reach people similar to those in your first-party data.If you have been using similar segments on Search or Shopping campaigns and are not using Smart Bidding, you should use Smart Bidding with your campaigns. If you're using Smart Bidding already, or running Performance Max campaigns, you don't need to take any action, since Performance Max campaigns automatically leverage signals from your first-party data.8. Google Introduces New Search Labels For Coupons & Promos - According to a recent survey by Google, among Americans planning to shop for the holidays, 43% are planning to look for deals and sales more than last year. And Google is a central part of the shopping experience for US customers. On average, 60% say they've used Google properties for shopping in the past two days. To help searchers find the items they want at the best available prices, Google is updating shopping search results with new labels highlighting coupons and promotions and the ability to compare prices from multiple retailers.The promotion badge in search results on items that offer a discount using a coupon code, such as “15% off with coupon code HOLIDAYS.” Furthermore, a new coupon clipping feature lets searchers save promo codes for when they're ready to buy. This is similar to what Bing already has in-place for a while. A new deal comparison tool in Google search results makes it easier to view deals across retailers. For example, if you search for “women's puffer coat,” Google will display a side-by-side comparison of available deals in the SERPs.Lastly, Google's price insights feature is coming to search results to help shoppers make more informed buying decisions. Price insights allow you to see prices across merchants and whether the price is low or high based on historical values.If you are looking to tap into all the good things mentioned above then you need to make sure you are using structured data and Google Merchant Center. And don't forget you can always see how your deals are performing and review your business' promotions as well through Google Merchant Center. 9. Google: Search Console Verified Sites Do Not Get Crawled More - Google's John Mueller was asked if sites that are verified with Google Search Console get crawled more often or at a higher priority. The answer is no, "crawling is independent of Search Console," John said.Yes, you can use the URL Inspection tool to manually push URLs to be crawled faster but that is on a URL by URL basis and must be done mostly manually. Otherwise, just having a Search Console account won't lead to expedited crawling.10. Google: Don't Rely Only On Backlinks For Rankings - Backlinks (also known as “inbound links”, “incoming links” or “one way links”) are links from one website to a page on another website. Google and other major search engines consider backlinks “votes” for a specific page. Pages with a high number of backlinks tend to have high organic search engine rankings. And back in March 2016 during a Q&A session, Google's Andrey Lipattsev revealed that backlinks, content and RankBrain are the top three ranking signals in Google's search algorithm. Now Google's John Mueller says that in the future he can see a Google Search ranking algorithm where links are not as important in the overall algorithm as they are today. He also hinted that links are not weighted as much as they were in the history of the Google ranking algorithm. Here is what he had to say when asked about backlinks:“Well, it's something where I imagine, over time, the weight on the links. At some point, will drop off a little bit as we can't figure out a little bit better how the content fits in within the context of the whole web. And to some extent, links will always be something that we care about because we have to find pages somehow. It's like how do you find a page on the web without some reference to it? But my guess is over time, it won't be such a big factor as sometimes it is today. I think already, that's something that's been changing quite a bit”This is a similar message to what Google's head of search spam, Matt Cutts, said in a 2014 video that backlinks, over time, will become a little less important.My advice is that focus on writing better content and do not just rely on backlinks or else you will be in for a big surprise down the road.11. Google: Header Fonts Size Is Irrelevant For SEO - Google's John Mueller was asked "would google deem huge heading font size as a sign of "overdoing it", thus lower quality?" He said that the size of your header tags, i.e. H1s, H2s, etc, does not matter for SEO or ranking purposes. John said it might matter for users and conversions but for SEO, nope. Another SEO myth busted.12. Google: Stop Focusing On Writing Content Solely Based On Search Volume - Google's John Mueller said that if you make your content creation decisions based off of keyword search volume lists, then those pieces of content will be mediocre, at best. What John is saying is that if you are looking for content ideas and use base them on a list of keywords that show high search volume, then the content likely won't be good enough to rank well in Google Search. In short, write content that you can write something awesome about, and do not force your writing based on what people are searching for - especially if you don't know the topic super well.John added, "seeing a list like that as a target for content makes me worry that you're not going to get a lot out of your work, or that your work is going to be quite superficial." He said "I'd look for topics that match your expertise & passion. Where can you contribute that isn't already covered by lots of others, and do so in ways that provide something new & useful? Don't focus on keywords & "search volume" lists like this, they'll lead you into mediocracy."In my opinion, writing content solely on keyword volume is ridiculous. You should be writing your content on what your product, subject, or the market needs are and make it superior to your competitors.Also, if you peruse the Search Essentials document, you will find that Google advices you to: "Use words that people would use to look for your content, and place those words in prominent locations on the page, such as the title and main heading of a page, and other descriptive locations such as alt text and link text." To an untrained eye, it may come across as an implicit advice that you need to write content using keyword lists or research. However, what this means is that instead of creating content on those highly searched keywords, make content about topics you are an expert in and then sprinkle those highly searched keywords.Great Educational and Informative content -- not keywords -- always wins.13. Google: Your Website Doesn't Need 200k+Words To Be Authoritative - A Twitter user @natmiletic claimed that "You need around 200,000 words on your website to be considered authoritative by Google." John replied, "I don't know who made up that 200,000-word number, it's definitely not from Google."I'm including the screenshots just in case the user deletes his tweets.Remember that in 2019, John said word count is not a ranking factor and in 2018 John said word count is not indicative of quality. Google won't penalize you for short articles and Google said short articles can rank well and then again in 2014 said short articles are not low quality. Google has been recently advocating to avoid fluff . In addition, word count is not a sign of thin or how helpful content is or is not. In fact, Google even removed the reference to word count in the Search Console document recently.This goes to show that how much crap & myth is out there. Aren't you glad that you follow the #TWiMshow?

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! En esta segunda parte de la entrevista con la doctora Lucía Redondo seguimos hablando sobre el SIBO; comenzamos por el H2S, y luego hablamos sobre el sobrecrecimiento de Candida, cómo se debe actuar desde la Nutrición y qué hacer cuando se ha hecho de todo y no se consigue mejorar. Encuentras a la doctora Lucía Redondo en https://redondocuevas.es/ Las notas del episodio como siempre en https://slowmedicineinstitute.com/podcast/ Este episodio está patrocinado por el podcast Tabú Mental de Amazon Music: https://music.amazon.es/podcasts/4a0aa891-1b94-4eae-ae78-9e44546fca2f/tab%C3%BA-mental Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! Un tema del que hasta ahora hemos hablado solamente en algunos episodios de preguntas y respuestas es el SIBO. Como es un tema que genera mucho interés, tenemos con nosotras a Lucía Redondo Cuevas, nutricionista y doctora en ciencias, y gran experta en SIBO. Esta es la primera parte de la entrevista, en la que hablamos sobre generalidades del SIBO y el IMO (el sobrecimiento de metanógenas). Profundizamos en SIBO de H2 y en IMO. En la segunda parte de la entrevista (la semana que viene) hablaremos sobre SIBO de H2S, dietas, y mucho más. Encuentras a la doctora Lucía Redondo en https://redondocuevas.es/ Las notas del episodio como siempre en https://slowmedicineinstitute.com/podcast/ Este episodio está patrocinado por el podcast Tabú Mental de Amazon Music: https://music.amazon.es/podcasts/4a0aa891-1b94-4eae-ae78-9e44546fca2f/tab%C3%BA-mental Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

This show dives into the history of H2S Scavengers and the work Q2 Technologies is doing to remove H2S and mercaptan in the Oil & Gas, Pulp & Paper, Wastewater, Landfill Gas, and Digester Biogas industries.We're bringing together the builders and innovators in energy in October 2022. Get your tickets for Fuze today: https://bit.ly/Fuze-OGS

Thank you to everyone who responded to the first episode about how to make clean, delicious natural wine. Your feedback was both encouraging and helpful. It became clear that there was a desire for this kind of information, and that there were things I needed to further explain from part 1.  This is a technical, detailed explanation of some of the important aspects of making wine naturally. If you haven't listened to part 1, this one will make a lot more sense if you do. Included in this part 2 episode are further discussions of optimal temperature and pH ranges for fermentation, everything you wanted to know about racking wine - when, how, how often, and why - and a comprehensive discussion of hydrogen sulfide (H2S) in wine and how to avoid and manage it, and many other aspects of natural winemaking.  Enjoy! Sponsor: https://www.centralaswine.com/

This month on Episode 38 of Discover CircRes, host Cynthia St. Hilaire highlights original research articles featured in the Jue 24th, July 8th and July 22nd issues of the journal. This episode also features an interview with the 2022 BCBS Outstanding Early Career Investigator Award finalists, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstadt.   Article highlights:   Nguyen, et al. miR-223 in Atherosclerosis.   Choi, et al. Mechanism for Piezo1-Mediated Lymphatic Sprouting   Kamtchum-Tatuene, et al.  Plasma Interleukin-6 and High-Risk Carotid Plaques   Li, et al. 3-MST Modulates BCAA Catabolism in HFrEF   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh. And today I'm going to be highlighting articles from our June 24th, July 8th and July 22nd issues of Circulation Research. I'm also going to have a chat with the finalists for the 2022 BCBS Outstanding Early Career Investigator Award, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstadt.   Cindy St. Hilaire:        The first article I want to share is from our June 24th issue and is titled, miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages. The first authors are My-Anh Nguyen and Huy-Dung Hoang, and the corresponding author is Katey Rayner and they're from the University of Ottawa. A combination of cholesterol accumulation in the blood vessels and subsequent chronic inflammation that's derived from this accumulation drive the progression of atherosclerosis. Unfortunately, current standard medications tackle just one of these factors, the cholesterol. And this might explain why many patients on such drugs still have vascular plaques. In considering treatments that work on both aspects of the disease, meaning lipid accumulation and inflammation, this group investigated the micro RNA 223 or miR-223, which is a small regulatory RNA that has been shown to suppress expression of genes involved in both cholesterol uptake and inflammatory pathways in both liver and immune cells.   Cindy St. Hilaire:        The team showed that mouse macrophages deficient in miR-223, exhibited increased expression of pro-inflammatory cytokines and reduced cholesterol efflux compared with control cells. Overexpression of miR-223 had the opposite effects. Furthermore, atherosclerosis prone mice, whose hematopoietic cells lacked miR-223, had worse atherosclerosis with larger plaques and higher levels of pro-inflammatory cytokines than to control animals with normal levels of miR-223. These findings highlight miR-223's dual prompt, antiatherogenic action, which could be leveraged for future therapies.   Cindy St. Hilaire:        The second article I want to share is from our July 8th issue of Circulation Research and is titled, Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymph Expansion. The first author is Dongwon Choi and the corresponding author is Young-Kwon Hong, and they're from UCLA.   As well as being super highways for immune cells, lymph vessels are drainage channels that help maintain fluid homeostasis in the tissues. This network of branching tubes grows as fluids begin to flow in the developing embryo. This fluid flow induces calcium influx into the lymphatic endothelial cells, which in turn promotes proliferation and migration of these cells, leading to the sprouting of lymph tubules. But how do LECs, the lymphatic endothelial cells, detect fluid flow in the first place? Piezo1 is a flow and mechanosensing protein known for its role in blood vessel development and certain mutations in Piezo1 cause abnormal lymphatic growth in humans.   Cindy St. Hilaire:        This script found that Piezo1 is expressed in the embryonic mouse LECs and that the suppression of Piezo1 inhibits both flow activated calcium entry via the channel ORAI1, as well as downstream target gene activation. Overexpression of Piezo1, by contrast, induced the target genes. The team went on to show that mice lacking either Piezo1 or ORAI1 had lymphatic sprouting defects and that pharmacological activation of Piezo1 in mice enhanced lymphogenesis and prevented edema after tail surgery. Together, the results confirmed Piezo1's role in flow dependent lymphatic growth and suggest it might be a target for treating lymphedema.   Cindy St. Hilaire:        The third article I want to share is also from our July 8th issue and is titled, Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability and Progression. The first and corresponding author of this study is Joseph Kamtchum-Tatuene from University of Alberta.   Excessive plasma cholesterol and systemic inflammation are contributing factors in atherosclerosis. While traditional remedies have been aimed at lowering patient's lipid levels, drugs that tackle inflammation are now under investigation, including those that suppress Interleukin-6, which is an inflammatory cytokine implicated in the disease. Focusing on carotid artery disease, this group conducted a prospective study to determine whether IL-6 levels correlated with disease severity. 4,334 individuals were enrolled in the cardiovascular health study cohort. They had their blood drawn and ultrasounds taken at the start of the study and five years later. This group found IL-6 was robustly correlated with and predicted plaque severity independent of other cardiovascular risk factors. This study also determined that an IL-6 blood plasma level of 2.0 picograms/mls, identified individuals with the highest likelihood of plaque, vulnerability and progression. This threshold value could be used to select patients who might benefit from novel IL-6 lowering medications.   Cindy St. Hilaire:        The last article I want to share is from our July 22nd issue of Circulation Research and is titled, Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure. The first author is Zhen Li, and the corresponding author is David Lefer from Louisiana State University. Hydrogen sulfide, or H2S, is a compound that exerts mitochondrial specific actions that include the preservation of oxidative phosphorylation, mitochondrial biogenesis and ATP synthesis, as well as inhibiting cell death. 3-mercaptopyruvate sulfurtransferase, or 3-MST, is a mitochondrial H2S producing enzyme, whose functions in cardiovascular disease are not fully understood.   Cindy St. Hilaire:        This group investigated the global effects of 3-MST deficiency in the setting of pressure overload induced heart failure. They found that 3-MST was significantly reduced in the myocardium of patients with heart failure, compared with non failing controls. 3-MST knockout mice exhibited increased accumulation of branch chain amino acids in the myocardium, which was associated with reduced myocardial respiration and ATP synthesis, exacerbated cardiac and vascular dysfunction, and worsened exercise performance, following transverse aortic constriction. Restoring myocardial branched-chain amino acid catabolism, or administration of a potent H2S donor, ameliorated the detrimental effects of 3-MST deficiency and heart failure with reduced injection fraction. These data suggest that 3-MST derived mitochondrial H2S, may play a regulatory role in branch chain amino acid catabolism, and mediate critical cardiovascular protection in heart failure.   Cindy St. Hilaire:        Today, I'm really excited to have our guests, who are the finalists for the BCVS Outstanding Early Career Investigator Awards. Welcome everyone.   Hisayuki Hashimoto:   Thank you.   Anja Karlstaedt:          Hi.   Hisayuki Hashimoto:   Hi.   Matthew DeBerge:      Hello. Thank you.   Cindy St. Hilaire:        So the finalists who are with me today are Dr Hisayuki Hashimoto from Keio University School of Medicine in Tokyo, Japan, Dr Matthew Deberge from Northwestern University in Chicago and Dr Anja Karlstaedt from Cedar Sinai Medical Center in LA. Thank you again. Congratulations. And I'm really excited to talk about your science.   Hisayuki Hashimoto:   Thank you. Yes. Thanks, first of all for this opportunity to join this really exciting group and to talk about myself and ourselves. I am Hisayuki Hashimoto, I'm from Tokyo, Japan. I actually learned my English... I went to an American school in a country called Zaire in Africa and also Paris, France because my father was a diplomat and I learned English there. After coming back to Japan, I went to medical school. During my first year of rotation, I was really interested in cardiology, so I decided to take a specialized course for cardiology. Then I got interested in basic science, so I took a PhD course, and that's what brought me to this cardiology cardiovascular research field.   Matthew DeBerge:      So I'm currently a research assistant professor at Northwestern University. I'm actually from the Chicagoland area, so I'm really excited to welcome you all to my hometown for the BCVS meeting.   Cindy St. Hilaire:        Oh, that's right. And AHA is also there too this year. So you'll see a lot of everybody.   Matthew DeBerge:      I guess I get the home field advantage, so to speak. So, I grew up here, I did my undergrad here, and then went out in the east coast, Dartmouth College in New Hampshire for my PhD training. And actually, I was a viral immunologist by training, so I did T cells. When I was looking for a postdoctoral position, I was looking for a little bit of something different and came across Dr Edward Thorpe's lab at Northwestern university, where the interest and the focus is macrophages in tissue repair after MI. So, got into the macrophages in the heart and have really enjoyed the studies here and have arisen as a research assistant professor now within the Thorpe lab. Now we're looking to transition my own independent trajectory. Kind of now looking beyond just the heart and focusing how cardiovascular disease affects other organs, including the brain. That's kind of where I'm starting to go now. Next is looking at the cardiovascular crosstalk with brain and how this influences neuroinflammation.   Anja Karlstaedt:          I am like Hisayuki, I'm also a medical doctor. I did my medical training and my PhD in Berlin at the Charité University Medicine in Berlin, which is a medical faculty from Humboldt University and Freie University. II got really interested in mathematical modeling of complex biological systems. And so I started doing my PhD around cardiac metabolism and that was a purely core and computationally based PhD. And while I was doing this, I got really hooked into metabolism. I wanted to do my own experiments to further advance the model, but also to study more in crosstalk cardiac metabolism. I joined Dr Heinrich Taegteyer lab at the University of Texas in the Texas Medical Center, and stayed there for a couple of years. And while I was discovering some of the very first interactions between leukemia cells and the heart, I decided I cannot stop. I cannot go back just after a year. I need to continue this project and need to get funding. And so after an AHA fellowship and NIHK99, I am now here at Cedars Sinai, an assistant professor in cardiology and also with a cross appointment at the cancer center and basically living the dream of doing translational research and working in cardio-oncology.   Cindy St. Hilaire:        Great. So, Dr Hashimoto, the title of your submission is, Cardiac Reprogramming Inducer ZNF281 is Indispensable for Heart Development by Interacting with Key Cardiac Transcriptional Factors. This is obviously focused on reprogramming, but why do we care about cardiac reprogramming and what exactly did you find about this inducer ZNF281?   Hisayuki Hashimoto:   Thank you for the question. So, I mean, as I said, I'm a cardiologist and I was always interested in working heart regeneration. At first, I was working with pluripotent stem cells derived cardiomyocyte, but then I changed my field during my postdoc into directly programming by making cardiomyocyte-like cells from fiberblast. But after working in that field, I kind of found that it was a very interesting field that we do artificially make a cardiomyocyte-like cell. But when I dissected the enhanced landscape, epigenetic analysis showed that there are very strong commonalities between cardiac reprogramming and heart development. So I thought that, hey, maybe we can use this as a tool to discover new networks of heart development. And the strength is that cardiac reprogramming in vitro assay hardly opens in vivo assay, so it's really time consuming. But using dark programming, we can save a lot of time and money to study the cardiac transitional networks. And we found this DNF281 from an unbiased screen, out of 1000 human open reading frames. And we found that this gene was a very strong cardiac reprogramming inducer, but there was no study reporting about any functioning heart development. We decided to study this gene in heart development, and we found out that it is an essential gene in heart development and we were kind of able to discover a new network in heart development.   Cindy St. Hilaire:        And you actually used, I think it was three different CRE drivers? Was that correct to study?   Hisayuki Hashimoto:   Ah, yes. Yeah.   Cindy St. Hilaire:        How did you pick those different drivers and what, I guess, cell population or progenitor cell population did those drivers target?   Hisayuki Hashimoto:   So I decided to use a mesodermal Cre-driver, which is a Mesp1Cre and a cardiac precursor Cre-driver, which is the Nkx2-5 Cre and the cardiomyocyte Cre, which is the Myh6-Cre. So three differentiation stages during heart development, and we found out that actually, DNF281 is an essential factor during mesodermal to cardiac precursor differentiation state. We're still trying to dig into the molecular mechanism, but at that stage, if the DNF281 is not there, we are not able to make up the heart.   Cindy St. Hilaire:        That is so interesting. Did you look at any of the strains that survived anyway? Did you look at any phenotypes that might present in adulthood? Is there anything where the various strains might have survived, but then there's a kind of longer-term disease implicating phenotype that's observed.   Hisayuki Hashimoto:   Well, thank you for the question. Actually, the mesodermal Cre-driver knocking out the DNF281 in that stage is embryonic lethal, and it does make different congenital heart disease. And they cannot survive until after embryonic day 14.5. The later stage Nkx2-5 Cre and Myh6-Cre, interestingly, they do survive after birth. And then in adult stage, I did also look into the tissues, but the heart is functioning normally. I haven't stressed them, but they develop and they're alive after one year. It looks like there's really no like phenotype at like the homeostatic status.   Cindy St. Hilaire:        Interesting. So it's kind of like, once they get over that developmental hump, they're okay.   Hisayuki Hashimoto:   Exactly. That might also give us an answer. What kind of network is important for cardiac reprogramming?   Cindy St. Hilaire:        So what are you going to do next?   Hisayuki Hashimoto:   Thank you. I'm actually trying to dig into the transitional network of what kind of cardiac transitional network the ZNF281 is interacting with, so that maybe I can find a new answer to any etiology of congenital heart disease, because even from a single gene, different mutation, different variants arise different phenotypes in congenital heart disease. Maybe if I find a new interaction with any key cardiac transitional factors, maybe I could find a new etiology of congenital heart disease phenotype.   Cindy St. Hilaire:        That would be wonderful. Well, best of luck with that. Congratulations on an excellent study. Hisayuki Hashimoto:   Thank you.   Cindy St. Hilaire:        Dr DeBerge, your study was titled, Unbiased Discovery of Allograft Inflammatory Factor-1 as a New and Critical Immuno Metabolic Regulatory Node During Cardiac Injury. Congrats on this very cool study. You were really kind of focused on macrophages in myocardial infarction. And macrophages, they're a Jeckel Hyde kind of cell, right? They're good. They're bad. They can be both, almost at the same time, sometimes it seems like. So why were you interested in macrophages particularly in myocardial infarction, and what did you discover about this allograft inflammatory factor-1, or AIF1 protein?   Matthew DeBerge:      Thank you. That's the great question. You really kind of alluded to why we're interested in macrophages in the heart after tissue repair. I mean, they really are the central mediators at both pro-inflammatory and anti-inflammatory responses after myocardial infarction. Decades of research before this have shown that inflammation has increased acutely after MI and has also increased in heart failure patients, which really has led to the development of clinical efforts to target inflammatory mediators after MI. Now, unfortunately, the results to target inflammation after MI, thus far, have been modest or disappointing, I guess, at worst, in the respect that broadly targeting macrophage function, again, hasn't achieved results. Again, because these cells have both pro and anti-inflammatory functions and targeting specific mediators has been somewhat effective, but really hasn't achieved the results we want to see.   Matthew DeBerge:      I think what we've learned is that the key, I guess, the targeting macrophage after MI, is really to target their specific function. And this led us to sort of pursue novel proteins that are mediating macrophage factor function after MI. To accomplish this, we similarly performed an unbiased screen collecting peri-infarct tissue from a patient that was undergoing heart transplantation for end stage heart failure and had suffered an MI years previously. And this led to the discovery of allograft inflammatory factor-1, or AIF1, specifically within cardiac macrophages compared to other cardiac cell clusters from our specimen. And following up with this with post-mortem specimens after acute MI to show that AIF1 was specifically increased in macrophages after MI and then subsequently then testing causality with both murine model of permanent inclusion MI, as well as in vitro studies using bone marrow drive macrophages to dig deeper mechanistically, we found that AIF1 was crucial in regulating inflammatory programing macrophages, which ultimately culminated in worse in cardiac repair after MI.   Cindy St. Hilaire:        That's really interesting. And I love how you start with the human and then figure out what the heck it's doing in the human. And one of the things you ended up doing in the mouse was knocking out this protein AIF1, specifically in macrophage cells or cells that make the macrophage lineage. But is this factor in other cells? I was reading, it can be intracellular, it can be secreted. Are there perhaps other things that are also going on outside of the macrophage?   Matthew DeBerge:      It's a great question. First, I guess in terms of specificity, within the hematopoietic compartment, previous studies, as well as publicly available databases, have shown that AIF1 is really predominantly expressed within macrophages. We were able to leverage bone marrow chimera mice to isolate this defect to the deficiency to macrophages. But you do bring up a great point that other studies have shown that AIF1 may be expressed in other radio-resistant cell populations. I mean, such as cardiomyocytes or other treatable cells within the heart. We can't completely rule out a role for AIF1 and other cell populations. I can tell you that we did do the whole body knockout complementary to our bone marrow hematopoetic deficient knockouts, and saw that deficiency of AIF1 within the whole animal, recapitulate the effects we saw within the AIF1 deficiency within hematopoietic department.   Matthew DeBerge:      It was encouraging to us that, again, the overall role of AIF1 is pro-inflammatory after MI.   Cindy St. Hilaire:        I mean, I know it's early days, but is there a hint of any translational potential of these findings or of this protein?   Matthew DeBerge:      Yeah, I think so. To answer your question, we were fortunate enough to be able to partner with Ionis that develops these anti-sensible nucleotides so that we could specifically target AIF1 after the acute phase during MI. We saw that utilizing these anti-sensible nucleotides to deplete AIF1, again, within the whole mouse, that we were able to reduce inflammation, reduce in heart size and preserve stock function. I think there really is, hopefully a therapeutic opportunity here. And again, with it being, perhaps macrophage specific is, even much more important as we think about targeting the specific function of these cells within the heart.   Cindy St. Hilaire:        Very cool stuff. Dr Karlstaedt, the title of your submission is, ATP Dependent Citrate Lyase Drives Metabolic Remodeling in the Heart During Cancer. So this I found was really interesting because you were talking about, the two major killers in the world, right? Cardiovascular disease and cancer, and you're just going to tackle both of them, which I love. So obviously this is built on a lot of prior observations about the effects of cancer on cardiac metabolic remodeling. Can you maybe just tell us a little bit about what is that link that was there and what was known before you started?   Anja Karlstaedt:          Yeah. Happy to take that question. I think it's a very important one and I'm not sure if I will have a comprehensive answer to this, because like I mentioned at the beginning, cardio-oncology is a very new field. And the reason why we are starting to be more aware of cancer patients and their specific cardiovascular problems is because the cancer field has done such a great job of developing all these new therapeutics. And we have far more options of treating patients with various different types of cancers in particular, also leukemias, but also solid tumors. And what has that led to is an understanding that patients survive the tumors, but then 10, 20 years later, are dying of cardiovascular diseases. Those are particular cardiomyopathies and congestive heart failure patients. What we are trying, or what my lab is trying to do, is understanding what is driving this remodeling. And is there a way that we can develop therapies that can basically, at the beginning of the therapy, protect the heart so that this remodeling does not happen, or it is not as severe.   Anja Karlstaedt:          Also, identifying patients that are at risk, because not every tumor is created equally and tumors are very heterogeneous, even within the same group. To get to your question, what we found is, in collaboration actually with a group at Baylor College of Medicine, Peggy Goodell's group, who is primarily working on myeloid malignancies, is that certain types of leukemias are associated with cardiomyopathies. And so when they were focusing on the understanding drivers of leukemia, they noticed that the hearts of these animals in their murine models are enlarged on and actually developing cardiomyopathies. And I joined this project just very early on during my postdoc, which was very fortunate and I feel very lucky of having met them. What my lab is now studying here at Cedars is how basically those physiological stress and mutations coming from the tumors are leading to metabolic dysregulation in the heart and then eventually disease.   Anja Karlstaedt:          And we really think that metabolism is at the center of those disease progressions and also, because it's at the center, it should be part of the solution. We can use it as a way to identify patients that are at risk, but also potentially develop new therapies. And what was really striking for us is that when we knock down ACLY that in a willdtype heart where the mouse doesn't have any tumor disease, ACLY actually is critically important for energy substrate metabolism, which seems counterintuitive, because it's far away from the mitochondria, it's not part of directly ADP provision. It's not part of the Kreb cycle. But what we found is that when we knock it out using a CRISPR-Cas9 model, it leads to cardiomyopathy and critically disrupts energy substrate metabolism. And that is not necessarily the case when the mouse has leukemia or has a colorectal cancer, which upregulated in the beginning, this enzyme expression. And so we have now developed models that show us that this could be potentially also therapeutic target to disrupt the adverse remodeling by the tumor.   Cindy St. Hilaire:        That is so interesting. So one of the things I was thinking about too is we know that, I mean, your study is showing that, the tumor itself is causing cardiac remodeling, but we also know therapies, right? Radiation, chemotherapy, probably some immune modulatory compounds. Those probably do similar, maybe not exactly similar, but they also cause, adverse cardiac remodeling. Do you have any insights as to what is same and what is different between tumor driven and therapy driven adverse remodeling?   Anja Karlstaedt:          So we do not know a lot yet. It's still an open question about all the different types of chemotherapeutics, how they are leading to cardio toxicities. But what we know, at least from the classic anti-cyclic treatments, is right now at the core, the knowledge is that this is primarily disrupting cardiac mitochondrial function. And through that again, impairing energy provision and the interaction, again, with the immune system is fairly unknown, but we know through studies from Kathryn Moore and some very interesting work by Rimson is that myocardial infarction itself can lead to an increase in risk for tumor progression. And what they have shown as independent of each other, is that the activation of the immune system in itself can lead to an acceleration of both diseases, both the cardiac remodeling, and then also the tumor disease. We don't fully understand which drivers are involved, but we do know that a lot of the cardiomyopathies on cardiotoxicities that are chemotherapeutically driven, all have also metabolic component.   Cindy St. Hilaire:        Nice. Thank you. When I prepare for these interviews, I obviously read the abstracts for the papers, but I found myself also Googling other things after I read each of your abstracts. It was a rabbit hole of science, which was really exciting.                               I now want to transition to kind of a career angle. You all are obviously quite successful, scientifically, at the bench, right? But now you are pivoting to a kind of completely opposite slash new job, right? That of, independent researcher. I would love to hear from each of you, if there was any interesting challenge that you kind of overcame that you grew from, or if there was any bit of advice that you wish you knew ahead of time or anything like that, that some of our trainee listeners and actually frankly, faculty who can pass that information onto their trainees, can benefit from.   Anja Karlstaedt:          I think the biggest challenge for me in transitioning was actually the pandemic. Because I don't know how it was for Hisa and Matt, but trying to establish a lab, but also applying for faculty position during a major global pandemic, is challenging is not quite something that I expected that would happen. And so I think saying that and looking more conceptually and philosophically at this as, you can prepare as much as you want, but then when life just kicks in and things happen, they do happen. And I think the best is to prepare as much as you can. And then simply go with the flow. Sometimes one of my mentors, Dave Nikon, mentioned that to me when I was applying for faculty positions, it's sometimes good to just go with the flow. And as a metabolism person, I absolutely agree. And there are some things that you can do as a junior investigator.   Anja Karlstaedt:          We need to have a good network. So just very important to have good mentors. I was blessed with have those mentors, Peggy Goodell's one of them, Heinrich Taegtmeyer was another. And now with this study that we are publishing, Jim Martin and Dave Nikon were incredible. Without them, this study wouldn't have been possible and I would not be here at Cedars.   Anja Karlstaedt:          You need to reach out to other people because those mentors have the experience. They have been through some of this before. Even if they have never had a major event, like COVID-19 in their life before, because none of us had before, they had other experiences and you can rely on them and they set you then up for overcoming these challenges. And the other thing I would say, is put yourself out there, go and talk to as many people as possible or set conferences, present a poster, not only talks. Don't be disappointed if you don't get a talk, posters are really great to build this network and find other people that you probably wouldn't have encountered and apply for funding. Just again, put yourself out there and try to get the funding for your research. Even if it's small foundations, it builds up over time and it is a good practice to then write those more competitive grants.     Cindy St. Hilaire:        Dr Hashimoto, would you like to go next?   Hisayuki Hashimoto:   Just my advice is that, could be like a culture of difference, but in east Asia, like in Japan, we were taught to, do not disturb people, don't interrupt people and help people. But I realized that I wasn't really good at asking for help. After I am still not like fully independent, but I do have my own group and I have to do grant writing. I still work at the bench and then have to teach grad students, doing everything myself. I just realized it's just impossible. I didn't have time. I need like 48 hours a day. Otherwise, you won't finish it. I just realized that I wasn't really good at asking for help. So my advice would be, don't hesitate to ask for help. It's not a shame. You can't do everything by just yourself. I think, even from the postdoc, even from grad school, I think, ask for help and then get used to that. And then of course, help others. And that is the way I think to probably not get overwhelmed and not stress yourself. Science should be something fun. And if you don't ask for help and if you don't help someone, I think you are losing the chance of getting some fun part from the science.   Cindy St. Hilaire:        That's great advice. I really like that, especially because I find at least, I started my lab seven years ago now. And I remember the first couple months/year, it was extremely hard to let go, right? Like I taught my new people how to do the primary cell culture we needed, but I was terrified of them doing it wrong or wasting money or making too many mistakes. But you realize, you got to learn to trust people. Like you said, you got to learn to ask for help. And sometimes that help is letting them do it. And you doing, you're being paid now to write grants and papers. That's a big brain, you're not paid to do the smaller things. That's really great advice. I like that. Thank you. Dr DeBerge, how about you?   Matthew DeBerge:      So I guess towards a bit of life advice, I think two obvious things is one, be kind, science is hard enough as it is. So I think we should try to lift each other up and not knock each other down. And along those lines as the others have alluded to as well, one of the mantras we sort of adapted on the lab, is a rising tide raises all ships, this idea that we can work together to elevate each other's science and really, again, collaborate.   Towards the career side of things I'll just touch on, because I guess one thing I'll add, there's more than one path, I guess, to achieving your goals. I've been fortunate enough to have an NIH post-doctoral fellowship and had an AHA career development award, but I'm not a K99 recipient. Oftentimes, I think this is the golden ticket to getting the faculty job, so I'm trying to, I guess, buck trend, I just submitted an RO1. So fingers crossed that leads to some opportunity.   Even beyond academia, I'm not certain how much everyone here is involved in science Twitter, it's really become a thing over the last couple years, but I think, kind of the elephant in the room is that academia, it's really hard on the trainees nowadays to have a living wage, to go through this. I mean, I'm really excited to see my, fellow finalists here are starting their own groups and stuff, but for many, that's not the reality for many, it's just not financially feasible. So I think, kind of keeping in mind that there's many, many alternative careers, whether it's industry, whether it's consulting, science writing, etcetera, going back to what Dr Hash says, find what you love and really pursue that with passion.   Cindy St. Hilaire:        I think it's something only, I don't know, five to 10% of people go into or rather stay in academia. And that means, 90 to 95% of our trainees, we need to prepare them for other opportunities, which I think is exciting, because it means it can expand our network for those of us in academia.   Anja Karlstaedt:          I think right now it's even worse because it's about 2% of old postdocs that are actually staying and becoming independent researchers, independent or tenure track or research track. And I think I second, as what Matt said, because I play cello. I do music as a hobby and people always ask me if I'm a musician. And at the beginning I felt like, no, of course not. I'm not like Yoyo Ma. I'm just playing, it's a hobby. And then I, that got me thinking. I was like, no, of course you are because there's so many different types. And what we need to understand is that scientists, like you are always a scientist. It doesn't matter if you are working at Pfizer or if you are working at a small undergrad institution and you're teaching those next generation scientists, you are still scientist and we all need those different types of scientists because otherwise, if everybody is just a soloist, you are never going to listen to symphony. You need those different people and what we need to normalize beyond having those different career paths, is also that people are staying in academia and becoming those really incredible resources for the institutions and labs, quite frankly, of being able to retain those technologies and techniques within an institution. And I think that's something to also look forward to, that even if you're not the PI necessarily, you're the one who is driving those projects. And I hope to pass this on at some point also to my trainees that they can be a scientist, even if they're not running a lab and they become an Institute director and that's also critically important.   Cindy St. Hilaire:        There's lots of ways to do science. Thank you all so much for joining me today. Either waking up at 5:00 AM or staying up past midnight, I think it is now in Japan or close to it. So Matt and I kind of made it out okay. It's like 8:00 or 9:00 AM.   Matthew DeBerge:      Thank you.   Hisayuki Hashimoto:   My apologies for this time zone difference.   Cindy St. Hilaire:        I'm very glad to make it work. Congratulations to all of you, your presentations. I forget which day of the week they are on at BCVS, but we are looking forward to the oral presentations of these and congratulations to all of you. You are amazing scientists and I know I'm really looking forward to seeing your future work so best of luck.   Matthew DeBerge:      Thank you.   Hisayuki Hashimoto:   Thank you.   Anja Karlstaedt:          Thank you so much.   Cindy St. Hilaire:        That's it for the highlights from the June 24th, July 8th and July 22nd issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle at CircRes and hashtag Discover CircRes. Thank you to our guests. The BCVS Outstanding Early Career Investigator Award Finalists, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstaedt. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire. And this is Discover CircRes, you're on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information visit ahajournals.org.  

We're taking a trip back to high school chemistry in this episode! The chemical compound H2S, better known as the gaseous chemical Hydrogen Sulfide--the one that puts off a "rotten eggs" smell, is found in many natural environment settings. However, did you know that Hydrogen Sulfide is produced in small amounts in our bodies? This over-looked compound has a variety of important physiological effects, especially as we age. Dr. Chris Hine has been studying these benefits and how H2S may actually help stave off Glioblastoma (GBM)! Both Dr.'s Hine and Lathia have been hard at work at the Lerner Research Institute at Cleveland Clinic finding out-of-the-box ways to better treat or help prevent brain cancers such as GBM. In this episode, we take a deeper look into their work. Season Presenting Sponsor: Gamma Tile (GT Medical Technologies)   Episode Sponsors: OncoSynergy, Inc. & Highmark BCBS of WNY

Redshift gives a masterclass on how they're using plasma to dissociate H2S molecules to produce hydrogen—taking a waste product in refineries and turning it into a useful product!https://www.rsenrg.com/https://www.linkedin.com/in/howard-nelson-3964161/https://www.linkedin.com/in/trey-anthony-1823424/

 So, before we get started today, I wanted to let you know that I'm currently off on annual leave, one of my goals this year was to take more time off – well, to basically time off, rather than working through until Christmas!  And so, the episode you're hearing today is a replay of a past episode. As it's IBS Awareness Month, and because so many of us with endo have IBS, I wanted to share with you my most foundational, actionable and informative episodes on endo belly, IBS and SIBO – so every week you'll get two episodes on this theme, to help raise awareness and to provide you with some actions. Now because these episodes are old, I may not refer to some of the resources I provide on the endo belly, so I wanted to remind you of the services I provide. So, to start with, I have plenty of other episodes on the endo belly, I have a course called The Endo Belly Course which is specifically for anyone with endo who really struggles with IBS, endo belly or SIBO (here's the waitlist; I work with 1 to 1 clients; especially those with endo belly or SIBO, and I have lots and lots of articles on Endometriosis News and Endometriosis Net about these topics. And of course, I also   have my Instagram account, which is chock full of SIBO and endo belly info, for those of you wanting to learn more. Lastly, if you feel you need a little extra support, I am currently running a free Endo Belly Challenge. The challenge ends on April 18th, but if you sign up before May 2nd, you'll still be able to access all of the challenge, and catch up – and for anyone who takes part, you'll be invited to a private, free Q&A call with me at the start of May, where you'll get to ask me all your endo belly questions. Okay, so without further ado, let's get to the episode: It's finally here! The long awaited episode on how to test for SIBO. Many of you have been contacting me to ask how to get tested or whether you can test at home, so here's my episode discussing all the ins and outs. Here's a breakdown of some of the key points in the episode: Hydrogen and methane type SIBO can be detected through a SIBO breath test. You can order at-home kits. In my experience, most GPs won't/can't order SIBO breath tests and aren't familiar with it, though GI doctors may be able to and SIBO specialist doctors certainly can. A SIBO breath test involves drinking a solution of glucose or lactulose and breathing into a test tube for 2-3 hours. The substrate will feed the bacteria, which will create fermentation, and the gas is then collected in the test tube and measured in the lab in parts per million. Tests can be either 2 hours with 8 test tubes or 3 hours with 10 test tubes. 2 hours runs the risk of missing SIBO in a person with slow gut motility, so for that reason, I prefer to go with a 3 hour test. Some specialists prefer testing with glucose, others lactulose. I like to use lactulose as glucose is absorbed in the first 1-3 feet of the small intestine and the small intestine is on average 22 ft long! So if the SIBO is further down, a glucose test can miss it entirely. A prep diet and overnight fast is required before taking the test. This is a low to no carb diet of meat, fish, eggs, black tea or coffee. There are some allowances for vegans, vegetarians or diabetics. If a patient ate too many carbs, or did the prep test incorrectly it would skew the test results and the test would need to be redone. The North American breath testing consensus states that a positive for hydrogen would be a rise of 20 ppm or more (parts per million) from the baseline (the breath before drinking the solution) in the first 90 minutes. A positive for methane would be 10ppm or more in the whole 180 minutes, including the baseline. Dr Allison Siebecker, who I trained with, has a slightly different diagnostic range after years and years of working with SIBO clients and consulting with other SIBO specialists. A positive hydrogen for her would be 20ppm in the first 120 minutes, with no rise needed as long as the baseline isn't the highest number. Methane is 10 within 180 but if constipation was present, the methane would be positive if the reading was 3-9ppm. Though hydrogen sulfide SIBO cannot be detected with this test, some H2S patients have a flat line pattern that indicates the presence of H2S. This would be a result of 6ppm or less for hydrogen and 3ppm or less for methane. An elevated baseline (so not 0) is normal for methane. In the USA, lactulose requires a prescription so you would need to find a doctor who could help you order it. For a deeper dive and my breakdown on how to take the test itself, have a listen to the show! I really hope this episode helps those of you who are suspecting that SIBO may be the culprit behind your endobelly. Let's get social! Come say hello on Instagram or sign up to my newsletter. Sign up to The Endo Belly Course wait list here.  On March 28th I am running my second Endo Belly Challenge! In this 4-week challenge, you will learn the first steps to identifying the root causes of your endo belly and the initial tools to heal your swelling, gut issues and abdominal discomfort. Every Monday, you'll receive a new email with a little bit of endo belly education and an action to implement that week! This challenge is perfect for anyone who experiences abdominal swelling/bloating, gas, constipation, nausea, diarrhea/loose stools, acid reflux, indigestion or stomach cramps with their endometriosis - and it's entirely free. You can sign up here. My cookbook This EndoLife, It Starts with Breakfast is out now! Get 28 anti-inflammatory, hormone friendly recipes for living and thriving with endometriosis. Order your copy here. If you feel like you need more support with managing endometriosis, you can join Your EndoLife Coaching Programme. A 1-to-1 three month health and life coaching programme to help you thrive with endometriosis. To find out more about the programme and to discuss whether it could be right for you, email me at hello@thisendolife.com or visit my website. This episode is produced by Ora Podcasts. Ora provides audio editing, management and other services to make podcasting simple and sustainable for their clients. Health coaches, nutritionists, mediums, personal trainers, tarot readers, teachers, or just those striving for a better world, Ora can help you start and maintain your podcast. Get in touch today. This episode is sponsored by BeYou. Soothe period cramps the natural way with these 100% natural and discreet menthol and eucalyptus oil stick on patches and CBD range. Click here to find out more and to shop: https://beyouonline.co.uk This episode is sponsored by Semaine. Try their supplement for period pain and daily supplement for hormonal balance and PMS prevention with code ENDOLIFE to get 20% off your first order.

The Structural Epoxy System for sanitary sewer manholes provides the one of strongest epoxy-based manhole rehabilitation and lining systems available in the market. Often specified for manhole rehab projects, the system is also terrific for lining newly installed structures when high head pressure or high H2S is anticipated. The system's primary technology is a high build, fiber reinforced polymer epoxy. Categorized as an FRP, this Epoxytec system is the highest build liner and carries the best warranty offering within the Epoxytec portfolio when applied by Certified Applicators.

The Structural Epoxy System for sanitary sewer manholes provides the one of strongest epoxy-based manhole rehabilitation and lining systems available in the market. Often specified for manhole rehab projects, the system is also terrific for lining newly installed structures when high head pressure or high H2S is anticipated. The system's primary technology is a high build, fiber reinforced polymer epoxy. Categorized as an FRP, this Epoxytec system is the highest build liner and carries the best warranty offering within the Epoxytec portfolio when applied by Certified Applicators.

Have you ever experienced mood dysregulation ? Did you know that the inhalation of H2S can correct depressive-like behaviors in rats? Why meditation results in feelings of calmness, relaxation, and even euphoria? In this new episode of Chemocast, we're digging into the science behind chemotransmitters.

Writing SEO content is very different from writing content for social media or other platforms. Your goal in writing SEO content is to attract visitors to your blog, to your website, and to actually rank on Google. There should be a conscious effort to understand how users will behave on your site, what they need, and how fast they got what they are searching for. Ultimately, it boils down to making visitors happy.   Podcast Highlights: 00:00 Prologue 00:42 Introduction of the topic  00:55 Understanding what Google wants to show users in their search results. 02:05 Tools that you can use to help in writing SEO content. 02:47 A good headline and meta title are necessary to draw attention to your article. (...What is the difference between Headline One and the Meta Title?) 04:41 Why are subheadlines (H2s) equally important? 07:33 The importance of monitoring your published article with Google Analytics.  07:52 Other tools that can track and collect data on the scrolls people do in your article. 08:37 Recap 09:40 End Resources: Tools mentioned by Gert Mellak: InLinks - https://inlinks.net/ Surfer SEO - https://surferseo.com/ Hotjar - https://www.hotjar.com/ Crazy Eggs - https://www.crazyegg.com/   Connect with Gert Mellak: Website: https://seoleverage.com/ Email: info@seoleverage.com

In this episode, I talked with Mohamed Sorour, a student from the EAEAT, the Egyptian Academy For Engineering And Advanced Technology which is affiliated to the Ministry of Military Production of Egypt. We chatted about Geopolitics, the importance of the Oil & Gas Industry in Egypt and the Middle East, the discovery of the Zohr Field and its relevance in the new Natural Gas trend as well as how is life as an engineer in such arab states. We also discussed two processes, the Amine Gas Treating, which is used to "sweeten" or remove impurities of H2S in natural gas as well as the TEG Dehydration used also in Natural Gas Treating. I really enjoyed this one, since it is now a student in a not so conventional private university but a university affiliated to the Military Ministry as well as covering some theoretical concepts and HYSYS Simulations. Show Notes: https://www.chemicalengineeringguy.com/the-blog/podcast/mohamed-sorour-a-chemical-engineer-from-the-eaeat-academy-affiliated-to-the-ministry-of-military-production-in-egypt/ --- Send in a voice message: https://anchor.fm/chemical-engineering-guys/message

H2S: it's out there, we need to be aware of it and know how to plan around it. In this episode, Matt and Justin discuss what Hydrogen Sulfide (H2S) is, how it impacts drilling programs, and what mitigation plans can be put in place for when it is encountered.

Understanding the Dangers of Hydrogen Sulfide Gas. Hydrogen sulfide (H2S) gas is produced as a result of the microbial breakdown of organic materials in the absence of oxygen. It can be found in tanks, vaults, voids, and other confined spaces at industrial facilities including power plants. Besides being flammable and corrosive, H2S is also colorless and toxic, even in relatively low concentrations, so it is extremely hazardous to workers. In fact, it is the second-most-common cause of workplace inhalation fatalities behind carbon monoxide. H2S is noticeable initially by its rotten egg smell, but the gas can deaden senses making it difficult for workers to detect without a gas monitor. Veriforce CEO Colby Lane and Chris Detillier, senior safety analyst with Veriforce, were guests on The POWER Podcast. Veriforce is a leading provider of software and services that enhance workforce and community safety. Among its offerings is a training course called H2S Clear, which provides students with life-saving information while meeting the compliance requirements of ANSI/ASSP standards. “It's extremely toxic. As little as 700 parts per million can cause someone to immediately collapse, and they can die from it,” Detillier said. “So, it is very important to have a good training program in place.” Lane explained that Veriforce's training model essentially credentials and accredits instructors. Then, those instructors provide the training to actual workers. Detillier said he's received a lot of positive feedback every time he's taught a “train-the-trainer” class for H2S Clear. “We've had guys that have been in the industry for years—some of them who have previously been through H2S training—and after class would tell me how much that they learned from the class and appreciate the content that we have in there.”