Podcasts about h2s

⛔️ this ep again mentions suicide.Covering all loose ends from my recollections about working at Amec Foster Wheeler in Kuwait. Finally got to a point where I can move on from #GISchat about Kuwait. Discussed: 0:00 - 3:24 - Emotional impact 3:24 - 3:42 - Agenda3:42 - 22:50 - Use of ChatGPT to interpret arterial blood gas (ABG) test results and fully understand the brutality of the context of the assistant electrician being fired. The system also tells us the consequences in general of H2S gas poisoning.22:50 - 32:56 - Use of ChatGPT to support whistleblowers more generally32:56 - 38:23 Questioning a safety item on p. 37 of the 2016 Amec Foster Wheeler Sustainability Performance Report (https://ungc-production.s3.us-west-2.amazonaws.com/attachments/cop_2017/394131/original/AmecFW_Sustainability_Report_2016_lower_res.pdf?1497623860), 38:23 - 42:36 - Using ChatGPT to help on the North Korean workers angle, leading me to UN Resolution 2397 (http://main.un.org/securitycouncil/en/s/res/2397-%282017%29)42:36 - 50:00 - Use of ChatGPT to support whistleblowers more generally, this section also contains the system's useful summary of all that I have recounted.50:00 - 53:58 - What would be expected to happen _to someone left untreated_ who presented with the particular ABG test results this person had.53:58 - 58:56 - Justice regarding the NBTC Camp 4 building fire and respect for the dead.58:56 - 1:09:21 - Wood PLC compliance officer participation in the cover up and validity of an invitation from a colleague to do a secret investigation,1:09:21 - 1:14:54 - National Crime Agency, invitation to make a police report and plan to do so1:14:54 - 1:18:25 - International Labour Organisation and human trafficking charity (believe it may have been Unseen UK), engaging an investigative journalist1:18:25 - 1:27:41 - Financial Conduct Authority, the stock price since I began whistleblowing and risk for pensioners who depend on these firms being properly policed such that their collapse does not put people's retirement at risk. 1:27:41 - 1:28:50 - Short sellers.1:28:50 - 1:32:50 - Princess Bibi Nasser Al Sabah.1:32:50 - 1:37:32 - Emotional impact and concluding thoughts about responsibilities of the safety staff who made these reports to me.1:37:32 - The Map Maker's Border poem recital.

Kako zmanjšati emisije toplogrednih in kislih plinov kot sta npr. ogljikov dioksid (CO2) in vodikov sulfid (H2S), ena od osrednjih onesnaževalcev v industrijski proizvodnji, in jih znati celo ponovno izkoristiti v proizvodnih linijah? V Reaktorskem centru Podgorica blizu Ljubljane so v okviru evropskega projekta E-CODUCT pretekli teden zagnali pilotni elektrotermični katalitični reaktor z lebdečim slojem, kot so ga poimenovali partnerji projekta, ki ga koordinira Univerza v Ghentu (Belgija). Hkrati z njihovim zmanjšanjem naj bi odpadne pline s procesiranjem v tem reaktorju uporabili za proizvodnjo uporabnih kemikalij kot sta ogljikov monoksid (O) in žveplo (S). Ta pilotni reaktor (TRL 6) so razvili pod vodstvom Centra odličnosti nizkoogljične tehnologije (CO NOT) in Odseka za katalizo in reakcijsko inženirstvo na Kemijskem inštitutu v Ljubljani. Projekt ni pomemben le za naš raziskovalni in industrijski prostor temveč naj bi prispeval tudi k razvoju tehnologij za razogljičenje industrije in k inovacijam. Več o temi v oddaji pojasnita sodelujoča raziskovalca izr.prof.dr. Miha Grilc in dr. Igor Šljapnikov iz CO NOT in Kemijskega inštituta. FOTO: Pred reaktorjem TRL 6 ob zagonu projekta 8.aprila stojijo z leve, Miha Grilc, Joris Thybaut (Uni v Ghentu), Miran Gaberšček in Igor Šljapnikov VIR: Goran Tenze, Program Ars

Here we look at a missed opportunity to avoid the death of 49 people in an NBTC accommodation fire last year in Mangaf, Kuwait. The missed opportunity was in the firing of a worker in 2017 for calling an ambulance in response to an H2S gas poisoning at GC-30 in the North Kuwait Asset. Instead, he could have been listened to for stating that people are punished for speaking up about safety issues. NBTC, Amec Foster Wheeler, Petrofac and the Kuwait Oil Company could then have changed their safety practices. One is invited to wonder if the building fire killing 49 people 7 years later in 2024 would not have occurred if this change had occurred.We will have one more episode on Kuwait, then move on to Qatar and London, UK.

L'art de reconnaître la réduction dans le vin ------------------------ Vous ouvrez une belle bouteille, et … une odeur désagréable s'échappe de votre verre. Allumette, œuf pourri, chou cuit ou même caoutchouc brûlé ? Il s'agit vraisemblablement de réduction. Voilà ce que vous devez retenir à ce sujet ! Qu'est-ce que la réduction ? Pour simplifier, elle survient souvent lorsque le vin est dans un milieu fermé, comme pendant l'élevage ou en bouteille. Ce phénomène crée des arômes particuliers, qui résultent de la combinaison de l'absence d'oxygène et de la présence de composés soufrés. Quels arômes reconnaître ? Au 1ers stades : Allumette, ...(Composé responsable : le dioxyde de soufre, ou SO2) Par la suite: Œuf pourri, chou, caoutchouc brûlé, marais.( Composé responsable : le sulfure d'hydrogène ou H2S, voire mercaptan). Que faire face à un vin réduit ? Faites tourner le vin dans le verre pour l'oxygéner. Utilisez une carafe large pour aérer encore plus le vin. Cette oxygénation peut constituer une solution, si la réduction n'est pas assimilée à un défaut. Au-dessus d'un certain seuil, il n'y a malheureusement rien à faire, et le vin n'aura d'autre destin que de finir dans l'évier Tout cela, je vous en parle en détail dans cette leçon vidéo "Voilà comment reconnaître la RÉDUCTION dans le vin", à retrouver sur ma chaine : A bientôt ! Recevez votre kit du dégustateur : https://www.lecoam.eu/kit

Sintana Energy CEO Robert Bose recently spoke with Steve Darling from Proactive to provide an update on the company's second exploration campaign in Namibia's Orange Basin. The campaign is focused on Blocks 2813A and 2814B, governed by Petroleum Exploration License 83 (PEL 83), which is operated by Galp Energia. Sintana indirectly holds a 49% interest in Custos Energy, which maintains a 10% working interest in PEL 83, alongside NAMCOR's 10% stake. The PEL 83 Joint Venture recently announced a significant milestone: the successful drilling and logging of the Mopane-2A well (Well #4), which spud on December 2. The exploration revealed hydrocarbons in two reservoirs: a gas-condensate column in AVO-3, characterized by thin net pay within its sweet spot, and a light oil column in AVO-4. Bose highlighted the reservoirs' promising characteristics, including high-quality sands with excellent porosity, permeability, pressure, and fluid properties. Additionally, the reservoirs exhibited minimal CO2 content and no H2S or water contacts, further underscoring their quality. The data collected from Mopane-2A is now under analysis to deepen the understanding of the Mopane complex and evaluate its commercial viability. Meanwhile, the drillship has relocated to the Mopane-3X exploration well (Well #5) site, where drilling is set to target two stacked prospects, AVO-10 and AVO-13. Spudding for this well is scheduled for early January. This progress reflects Sintana Energy's commitment to advancing its exploration initiatives in one of the world's most promising emerging hydrocarbon basins. #proactiveinvestors #sintanaenergyinc #tsxv #sei #otcqb #seusf #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews #OilExploration #Namibia #OrangeBasin #EnergySector #PEL83 #RobertBose #GalpEnergia #Chevron #QatarEnergy #EnergyNews #ProactiveInvestors #2025EnergyTrends #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

Send us a message with this link, we would love to hear from you. Standard message rates may apply.This episode explores the science behind flatulence odor and introduces a simple, over-the-counter remedy: Pepto-Bismol. The episode explains that the unpleasant odor associated with flatulence is primarily caused by hydrogen sulfide (H2S), a gas produced in the colon during the breakdown of food. Pepto-Bismol, or bismuth subsalicylate, works by binding to hydrogen sulfide in the colon and reducing the amount of gas released. The episode highlights a study published in Gastroenterology which found that bismuth subsalicylate significantly reduced H2S release in human fecal samples. Participants in the study experienced a greater than 95% reduction in fecal H2S release after taking Pepto-Bismol for 3-7 days. The episode also emphasizes the importance of consulting a doctor before using Pepto-Bismol, especially for those with medical conditions or taking other medications.Support the showProduction and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

Norman is a versatile Geologic Consultant with 15+ years of success in exploration, development, and petroleum geology. History of success in on-site support, drilling strategy optimization, and team mentorship. Expertise in wireline log interpretation, H2S risk management, and thorough well-logging in diverse basins worldwide. Skilled in productivity assessments, geologic modeling, and data accuracy, driving impactful contributions to production and exploration projects. Adept at instructing, leading, and mentoring new team members, elevating their expertise and professional development. Leverage advanced knowledge in petroleum production estimation software, enabling precise petrophysical analysis, reservoir characterization, and forward-thinking production forecasting.

Technical Tips for When Things Go Wrong with Cider Making This episode features two cider professionals and a cider industry consultant, which is exactly who you need a direct line to when your cider has problems. Hear from Megan Faschoway who at the time of this recording was Senior Cider Maker at Sea Cider, Kira Bassingthwaighte Head Cider Maker at Western Cider in Montana and Nick Gunn of BenchGraft a cider consultation service based in Salem Oregon. This talk took place in Portland Oregon at CiderCon, the annual cider conference hosted by the American Cider Association. The title of the talk was “What to do when things go wrong”. The focus was not on preventive measures, but as the title says – curative steps that one can take to try to mitigate a problem with a particular cider In this Cider Chat on Cider Problems Dealing with rotten egg smell from your cider Hydrogen sulfide (H2S) is a negative off-aroma compound that can occur in cider and has a rotten egg smell. It's produced by the yeast Saccharomyces cerevisiae during cider fermentation. Filtering cider Using Reverse Osmosis (RO) Tasting Panels for feedback Dealing with a saturated cider maker's palate Saving samples from each batch to create a library for potential cider problems down the road Contact for Speakers on this Panel Kira Bassingthwaighte, Western Cider Hear Kira on Episode 295 Megan Faschoway Nick Gunn BenchGraft Hear Nick and Dave White of Whitewood Cider on Episode 004 Mentions in this Cider Chat French Cider Tour September 2024 Oliver's Cider and Perry Company – UK Cider in Herefordshire, Tom Oliver audio clip The Whose Who of #xpromotecider in this episode? Join the fun and download the info flyer on Cider Chat offerings at the Support Page! Post, share and social media and tag Cider Chat! Cider's XPromoters will be featured on an end of year episode!   De Gerdenner Cider, Netherland Northwest Cider Association reposted Episode 410 with Olympic Bluffs Cider and Lavender Farm Ross on Wye Cider and Perry Company posted last week's Episode 410 Perry Panel Dragon' Head Cider Camra Cider and Perry American Cider Association – CiderCon

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Newly launched Humane Slaughter Initiative webpage, published by Léa Guttmann on March 29, 2024 on The Effective Altruism Forum. This post was cross-posted by the Forum team with the permission of the author. The author may not see or respond to comments on this post. Greetings from Shrimp Welfare Project! Our team is excited to announce the launch of our new webpage dedicated to the Humane Slaughter Initiative! This initiative aims to revolutionise the way shrimps are stunned prior to slaughter and pave the way for the future of ethical shrimp production. Learn more about this new page below. In a newly published article on our website highlighting the urgency of responsible pond management, findings revealed alarmingly toxic hydrogen sulphide levels in shrimp ponds in India's Serepalem village, prompting a successful sludge removal intervention that significantly improved conditions - underscoring the imperative of sustainable practices for shrimp welfare and farm productivity. Tamar Stelling wrote a piece for De Correspondent in the Netherlands, highlighting our corporate engagement work with a focus on electrical stunning. It is a mix of in-depth shrimp welfare discussion, some recognition where it is due (e.g. Albert Heijn), and a lot of fun! Have a great week! Léa | SWP Communications Lead The Humane Slaughter Initiative webpage SWP is thrilled to announce the launch of our Humane Slaughter Initiative webpage! What's the initiative about? Until the end of 2025, SWP is providing ~24 shrimp producers with free electrical stunners on the condition they use it to stun a minimum of 1,500-2,000 metric tons of shrimp per year. The goal is to accelerate industry adoption of this more humane stunning method ahead of expected buyer demands and regulations. Why is it impactful? Scientific literature establishes shrimp sentience. In addition, consumer demand for higher welfare standards is increasing globally. Electrical stunning is also recognised as the most humane pre-slaughter method currently available for shrimps. It renders shrimp unconscious faster and more effectively than ice slurry immersion or asphyxia. Leading retailers like M&S and John Lewis Partnership have already committed to using electrical stunning, setting the stage for industry-wide adoption. What will you find on the page? This page serves as your go-to resource for our initiative, offering an in-depth overview, a breakdown of how Ace Aquatec and Optimar equipment function, and a summary of the eligibility requirements. Any questions? Our FAQ section may have your answers. Ready to apply? Fill out the application form you will find on the page. Tackling Hydrogen Sulphide levels in shrimp farms In a recently published article, Shrimp Welfare Project conducted a crucial study in the village of Serepalem, Andhra Pradesh, India, which found alarming findings of toxic levels of hydrogen sulphide (H2S) in all 38 tested ponds. This poses a severe respiratory toxin for shrimps. As an intervention, SWP facilitated sludge removal in a pond with 10 years of build-up, leading to a significant drop in H2S from hazardous to near-threshold levels. This small but impactful study underscores the importance of regular pond maintenance through cost-effective sludge removal to improve shrimp welfare and farm productivity. Moving forward, SWP plans to expand this sustainable intervention to other neglected areas. Dive Deeper If you want to learn more about shrimp welfare and the shrimp farming industry: SWP's pioneering efforts in advancing shrimp welfare, particularly through the Humane Slaughter Initiative, have gained recognition in a recent Global Seafood Alliance article, alongside advocacy by prominent retailers like Marks and Spencer, Waitrose & Partners, and Albert Heijn. The article showcases SWP's provision of...

Explore the often overlooked diagnosis of hydrogen sulfide SIBO (small intestine bacterial overgrowth) and its diverse array of symptoms, including food intolerances, inflammation, diarrhea and abdominal pain, shedding light on its association with conditions like IBD, colorectal cancer and Parkinson's Disease. Gain invaluable insights into testing, treatment and dietary adjustments crucial for managing hydrogen sulfide SIBO and reclaiming gut health. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, Twitter, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

There are many manhole rehabilitation and lining solutions in the market today designed to resolve various sanitary sewer collection system problems. Most are designed for H2S protection, some focus on strength, however few are formulated with a balance to specifically abate inflow and infiltration (I/I) while also protecting against corrosion. Let's explore the many types of applied liners used in manhole rehabilitation, including cementitious products, ultra-high build epoxies, polyurethanes, and polyureas. Each of these technologies have their strengths and weaknesses.

#291 Dr. Goldenberg is passionate about how we evaluate and utilize evidence. He is an active researcher with numerous publications in high-impact scientific journals such as JAMA and the BMJ and is an Associate Research Investigator at the Helfgott Research Institute. He is faculty for the Academy of Integrative Health and Medicine and the Helfgott Research Institute where he teaches critical evaluation of the medical literature and advanced evidence synthesis. His love for teaching integrative evidence-based medicine led him to found the DrJourncalClub website and Podcast. He received his Doctorate in Naturopathic Medicine from Bastyr University and his Bachelor's in Molecular Biology with honors from the University of Pennsylvania. He is a past  President of the Gastroenterology Association of Naturopathic Physicians and a Fellow of the American Board of Naturopathic Gastroenterology. His clinical focus is on integrative approaches to gastroenterology conditions with a special focus on small intestinal bacterial overgrowth. He sees patients virtually at the Goldenberg GI Center. His interest in evidence has taken him from clinic to courtroom, recently co-founding three businesses focusing on brain injury litigation and forensic epidemiology. In this episode we cover What is hydrogen sulfide and what is its function in the body When does hydrogen sulfide  become a problem and what may one experience if they have H2S overgrowth Joshua's insight from his current research on Hydrogen Sulphide SIBO How is Joshua currently testing for it? He sheds light on the new at-home handheld devices for SIBO testing Treatment strategies for Hydrogen sulphide SIBO And so much more

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, “Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome.” Hutchinson-Gilford progeria syndrome (HGPS) is a rare human disease characterized by accelerated biological aging. Current treatments are limited, and most patients die before 15 years of age. Hydrogen sulfide (H2S) is an important gaseous signaling molecule that is central to multiple cellular homeostasis mechanisms. Dysregulation of tissue H2S levels is thought to contribute to an aging phenotype in many tissues across animal models. Whether H2S is altered in HGPS is unknown. In a new study, researchers Stephen E. Wilkie, Diana E. Marcu, Roderick N. Carter, Nicholas M. Morton, Susana Gonzalo, and Colin Selman from the University of Glasgow, University of Edinburgh, Saint Louis University, and Karolinska Institute investigated hepatic H2S production capacity and transcript, protein and enzymatic activity of proteins that regulate hepatic H2S production and disposal in a mouse model of HGPS (G609G mice, mutated Lmna gene equivalent to a causative mutation in HGPS patients). “This study was designed and undertaken due to the lack of understanding in the mechanistic targets of known treatments against HGPS and considering the positive association between H2S and longevity in model organisms.” Here, the researchers employed the HGPS mouse model G609G to test the hypothesis that, in contrast to anti-aging increases in H2S production, the accelerated aging typical of progeroid mice is associated with reduced hepatic H2S production. G609G mice were maintained on either regular chow (RC) or high fat diet (HFD). HFD has been previously shown to significantly extend lifespan of G609G mice, and compared to wild type (WT) mice maintained on RC. RC-fed G609G mice had significantly reduced hepatic H2S production capacity relative to WT mice, with a compensatory elevation in mRNA transcripts associated with several H2S production enzymes, including cystathionine-γ-lyase (CSE). H2S levels and CSE protein were partially rescued in HFD fed G609G mice. The data acquired here confirmed some aspects of the relevance of H2S in HGPS but raises more questions about the specific mechanisms at play. “Regardless, the work presented here addresses an area of research that remains critically understudied and provides new evidence that the accelerated ageing phenotype observed in HGPS may be partially explained by a reduction in hepatic H2S levels.” DOI - https://doi.org/10.18632/aging.204835 Corresponding authors - Colin Selman - colin.selman@glasgow.ac.uk, and Stephen E. Wilkie - stephen.wilkie@ki.se Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204835 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, progeria, hydrogen sulfide, high-fat diet, ageing, lamin A About Aging-US: Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at www.Aging-US.com​​ and connect with us on social media. MEDIA@IMPACTJOURNALS.COM

In this episode Sheldon speaks with Master Hydrogen Sulfide Trainer Stan Smiley. In this conversation, Sheldon and Mr. Smiley speak about the hidden dangers on Hydrogen Sulfide (H2S), H2S training and detergent suicide. Don't miss this revealing episode.

“You need to know all extraneous variables affecting your audience's pain point and use the LEMA framework to build content around that.”Lily introduces us to the LEMA Framework, which stands for Logic, Explicitness, Memorability, and Actionability. She explains that remarkable content needs to engage readers, be clear and explicit, leave a lasting impression, and provide actionable steps for the audience.Throughout the episode, Lily provides insights on how to apply the LEMA Framework to content creation. She highlights the importance of defining the search intent and target audience, crafting headings and subheadings that address the readers' knowledge level, and creating a thesis with novel ideas. Lily also emphasizes the significance of providing clear actions, breaking down complex information into digestible pieces, and using visuals to enhance understanding.Tune in to discover how to use the LEMA Framework to create content that captures your audience's attention and delivers value!In this episode, we talk about:Content strategyLema frameworktarget audienceTimestamps:[00:05] Introduction[01:20] Exploring the LEMA Framework: Logic, Explicitness, Memorability, and Actionability[06:37] Coined concepts, novelty, and relatability[09:45] Analyzing a blog post breakdown and defining search intent[15:00] Understanding the audience's needs and goals[17:17] Creating an outline tailored to audience interests[19:34] Crafting clear and specific H2s[24:50] Applying the LEMA Framework and tailoring content to different audiences[27:20] Wrap UpAbout Lily UgbajaLily Ugbaja is a Content Marketing Consultant who's helped brands like WordPress, Hubspot, and Zapier win more of their best buyers with content. She runs 3 blogs of her own and previously worked as a Content Marketing Manager at Animalz helping brands like SimpleLegal grow traffic by over 500%.Connect with Lily Ugbaja on LinkedIn: https://www.linkedin.com/in/lilyugbaja/  Join the Flying CatsStill feeling your stomach drop whenever you have to report organic growth to leadership? Things are about to change

What the heck is molecular hydrogen? Isn't it the same as hydrogen? Although it's not talked about in Western medicine circles, and the research is early, there are 2000+ scientific studies including over 100 clinical studies suggesting that H2 has therapeutic potential in over 170 different human and animal disease models, and in essentially every organ of the human body.H2 reduces oxidative stress and improves redox homeostasis partly mediated via the Nrf2 pathway, which regulates levels of glutathione, superoxide dismutase, catalase, etc.H2, like other gaseous-signaling molecules (e.g. NO•, CO, H2S), modulates signal transduction, protein phosphorylation, and gene expression, which provides anti-inflammatory, anti-allergy, and anti-apoptotic protective effectsMy guest today, Greg "The Hydrogen Man" talks about his personal experience using molecular hydrogen to save his health, and how he's helped others in terrible health like his father, who suffered from arthritis, glaucoma, and more. Hydrogen has also been shown to be extremely protective of the heart. In fact, in Japan, it's standard protocol to put those suffering from strokes on a molecular hydrogen machine. There are also several studies showing its positive effects during the pandemic for those suffering from pulmonary issues. If you're interested in grabbing the molecular hydrogen machine Greg talks about head over to Holy Hydrogen and use the code "JOELEVAN" for a discount.Additional ResourcesBenefits of HydrogenIntro OneStory Behind the MachineResearch

After doing this podcast I realised there is one huge thing people are not taking ownership of but absolutely should be – air quality. Think about it, we worry about our diet, but only eat a few times a day. We worry about exercising, but that's maybe an hour a day. But we breathe every second of every day, and what if what we are breathing is full of aggravating and inflammatory toxins?! David Millburn is the chief technology officer of Hypoair, a leading player in the air filtering space for over 15 years. Their proprietary technology is used from small homes to massive buildings. All their technology is backed by a huge amount of science, and uses cutting edge technology that creates proven and innovative results. Their tests are available upon request, and cover topics including VOCs, MERS, Molds, MRSA, O3, TBC, HCHO, RSP, NH3, H2S, and much more.Check out Hypoair's products at Made To Thrive and because you're a loyal listener, receive 10% off any of their amazing air cleaning products:https://madetothrive.co.za/special-deals/hypoair/Join us as we explore:Everything air quality – why it is so important for your health, the pollutants and toxins that are around us every day like molds, bacteria and viruses, the abundance of chemicals we think improve air quality but only make it worse, and why the air quality in your home is definitely worse than the air outside.The dynamic nature of air quality - how it changes throughout the day, how it depends on your unique geography, on your neighbors and easy tips you can try today to assess the air quality around you.The Hypoair technology, which product would be right for you and your home, Hypoair's philosophy of addressing each area of your home individually and why their devices were the first globally tested on their impact on COVID19.Why air quality extends beyond your home! What are the pollutants in your car? In the hotel rooms you travel to? And why Hypoair's mobile technology is your air quality game changer.Mentions:Website – Breezometer, https://breezometer.comSupport the showSupport the show on Patreon:As much as we love doing it, there are costs involved and any contribution will allow us to keep going and keep finding the best guests in the world to share their health expertise with you. I'd be grateful and feel so blessed by your support: https://www.patreon.com/MadeToThriveShowSend me a WhatsApp to +27 64 871 0308. Disclaimer: Please see the link for our disclaimer policy for all of our content: https://madetothrive.co.za/terms-and-conditions-and-privacy-policy/

Not only is the cider acclaimed, so too is the Maker Tom Oliver is just as acclaimed as his cider which makes Oliver's Cider and Perry Co. a global hit on two fronts. He is affable, engaging and knows his way around social media likely due to his work with the Scottish Rock Rock Band, The Proclaimers. Cidermakers are not well known for reposting news stories about themselves and their product, but Tom is a master of this one simple act that keeps Oliver's in the news and endears him to media. That singular step alone is just one of many giveaways that Tom provides to the slow moving cider industry. This topic is key for makers looking to up level their online presence, but it was not the topic of conversation in this episode. Instead Ria and Tom caught up after the world shut down for the past 2 plus years at CiderCon 2023 held in Chicago. In this chat How minimal intervention is key for Oliver's Cider and Perry What is Farmhouse cider Spontaneously fermented - wild yeast Tannic cider and Perry Pears At Oliver's there is no measuring of sugar or fiddling with the cider. In fact, Tom can be heard in most interviews saying "Don't fiddle with cider." What's new for this acclaimed makers and cidery? More c0-ferments and collaborations! Bâtonnage This is a technique used by winemakers, where the lees (yeast cells) are stirred into solution. Nano proteins are the biggest benefit of Bâtonnage They release into the cider providing a perception of sweetness and body with out the sugar Need at least 9 months to a year to get the nano proteins There are short term benefits. Yeast produces less carbon dioxide and bubbles. They slow down after the first primary ferment. Fermentation may have stopped but there is still sugar left. Lees absorb off aromas, except for H2S rotting egg smell. Bâtonnage helps to maintain a reductive state. Full reduction - rotting smell is a type of reduction. Which helps protect the cider from oxidization and protect the flavor components. Find out more about Bâtonnage by going to Episode 233: Ask Ryan Quarantine Quad Series where Ryan Monkman of Fieldbird Cider in Prince Edward County Canada provides an in depth overview of Bâtonnage and Maderisation (where the barrels are cooked). Contact info for Oliver's Cider and Perry Company Website: https://www.oliversciderandperry.co.uk/ Mentions in this chat Send your questions to info@ciderchat.com about fermentation and yeast for an upcoming Q&A with Fermentis - Yeast and Fermentation Solutions for Cidermakers Subscribe to eCiderNews

En esta segunda parte de nuestra serie de sabores no deseados o “off-flavours” hablamos de los Alcoholes Superiores y el H2S (Ac. Sulfhídrico), otros dos compuestos derivados de la fermentación. En la primera parte conversamos de los alcoholes superiores, de sus descriptores y causas más comunes. En la segunda parte damos una introducción a los compuestos azufrados, pero nos enfocamos en el H2S o ácido sulfhídrico, identificable cómo el olor a huevo podrido, muchas veces apreciable al comienzo de la fermentación y en especial en levaduras lager.   Si desean enviarnos comentarios pueden hacerlo a nuestro correo beercodeperu@gmail.com  o a nuestro Instagram @beercode.pe donde también encontrarás el link a nuestro DISCORD y a nuestras copas cerveceras.

Google's very own Martin Splitt joined me on the SEJ Show to share his thoughts and opinions on various technical SEO topics, such as Semantic HTML, Google Search Console, indexing, and client-side rendering. Explore how to leverage these powerful tools to improve your website's SEO. Prefer to watch the video? Register here: http://bit.ly/3YQxzG7  I would say make sure that you are focusing on the content quality and that you are focusing on delivering value to your users. Those have been, will always be, and are the most important things. Everything else should follow from that. –Martin Splitt Suppose you are fine-tuning technical details or your website's structure or markup. In that case, you are likely missing out on the more significant opportunities of asking yourself what people need from your website. –Martin Splitt This question keeps coming up. This is not the first time and will not be the last time this question will come up and continue to be asked. I don't know why everyone thinks about who, what value, or who. It's about structure. I can't emphasize this enough, if you choose to have H1s as your top-level structure of the content, that's fine. It just means that the top level of the content is structured along the H1s. –Martin Splitt   [00:00] - About Martin [02:47] - Why Semantic SEO is important. [04:22] - Is there anything that can be done within Semantic HTML to better communicate with Google? [06:02] - Should schema markup information match what's in the document? [08:24] - What parts of Semantic search does Google need the most help with? [09:19] - What is Martin's opinion on header tags? [14:22] - Is the responsibility of implementing Semantic HTML on the SEO or the developer? [16:19] - How accessible is Semantic HTML within a WordPress, or Gutenberg-style  environment?  [19:58] - How compatible is Semantic HTML with WCAG? [21:08] - What is the relationship of Semantic HTML to the overall concept of the Semantic web RDF, etc.? [25:04] - Can the wrong thumbnails be rectified utilizing Semantic HTML? [28:42] - Is there another type of schema markup that can still refer to the organization and use IDs on article pages? [32:10] - Can adding schema markup to show the product category hierarchy and modifying HTML help Google understand the relationship between the product and its category? [33:49] - Is preserving header hierarchy more critical than which header you use? [36:36] - Is it bad practice to display different content on pages to returning users versus new users? [40:08] - What are the best practices for error handling with SPAs? [45:31] - What is the best way to deal with search query parameters being indexed in Google?  [48:02] - Should you be worried about product pages not being included within the XML site map? [50:26] - How does Google prioritize headers? [56:00] - How important is it for developers and SEOs to start implementing Semantic HTML now? [57:31] - What should SEO & developers be focusing on?   If you understand that it's a 404, you have two options because two things can happen that you don't want to happen. One is an error page that gets indexed and appears in search results where it shouldn't. The other thing is that you are creating 404s in the search console and probably muddling with your data. –Martin Splitt If you have one H1 and nothing else under it except for H2s and then content H2 and then content H2, that doesn't change anything. That means you structured your content differently. You didn't structure it better. You didn't structure it worse. You just structured it differently. –Martin Splitt   For more content like this, subscribe to our YouTube channel: https://www.youtube.com/user/searchenginejournal  Are you looking to keep up with current and effective digital marketing today? Check out https://www.searchenginejournal.com  for everything you need to know within the digital marketing space and improve your skills as an internet marketer. Connect With Martin Splitt: Martin Splitt - the friendly internet fairy and code magician! He's a tech wizard from Zurich that has magic fingers when it comes to writing web-friendly code.  With over ten years' experience as a software engineer, he now works as a developer advocate for Google. A master of all things open source, his mission is to make your content visible in any corner of cyberspace - abracadabra! Connect with Martin on LinkedIn: https://www.linkedin.com/in/martinsplitt/ Follow him on Twitter: https://twitter.com/g33konaut   Connect with Loren Baker, Founder of Search Engine Journal: Follow him on Twitter: https://www.twitter.com/lorenbaker   Connect with him on LinkedIn: https://www.linkedin.com/in/lorenbaker  

Welcome to part 2 of our SEO dictionary  episode where we cover 10 more common SEO terms!Share us with a friend!1.  SEO terms discussed today include alt text, domain authority/rank, headings (H1s and H2s), 301 redirects, and more.Alt text is used to describe images for accessibility purposes. URL stands for Uniform Resource LocatorsDomain Authority measures how trustworthy a website is.Headings are where keywords should be strategically placed to optimize SEO.Canonical URLs designate one page you want Google to index while similar pages won't be indexed.A 301 Redirect allows an outdated page URL to go somewhere else instead of being broken2.  Fun facts about how the internet works: Bots are behind the scenes, indexing and crawling to help gather and analyze information.Amazon owns most of the online real estate due to its serves, making money through web services.Anchor texts should relate specifically to the link they are connected to ... try to avoid generic phrases like "click here."3.  Organic search is becoming more popular as a result of new search engines such as you.com, which does not rely on ads for its results.UnNoticed Entrepreneur - step into the spotlight.Entrepreneurs share their secrets to getting noticed in 20 minutes.Listen on: Apple Podcasts SpotifyIf you're looking for a unique, handcrafted way to spruce up your home or office, then Collage and Wood is the perfect place for you! We offer a range of beautiful wooden signs that are perfect for any occasion. Our talented team of artists will work with you to create a sign that perfectly suits your needs. So why wait? Visit Collage and Wood today!Support the showListen to the private podcast for just $10/mo: SEO Shorts helps you put a simple & *strong* SEO strategy in place, today!Be our (podcast) guest! Apply hereB's SEO Basics Checklistbrittanyherzberg.com / Instagram 10,000 Jasper words FREE!crystalwaddell.comGet the Show merch!

In this episode, Sheldon continues the conversation with Certified H2S Master Instructor, Stan Smiley. Stan gives stories of his time in oil and gas, emergency response, and case studies related to H2S exposure. If you are exposed to hydrogen sulfide, then this is a must listen episode for understanding this common hazard.

Happy New Year! It's 2023 and Sheldon starts the year off with a important interview with H2S Certified Master Trainer, Stan Smiley. Mr. Smiley is one of a rare group of safety educators that bear the distinction of excellence in this by being designated as a Hydrogen Sulfide (H2S) Master Instructor®, numbering less than 123 worldwide and of those, one of 41 currently certified. Primus Global Media will host a H2S Instructor Development Course this February 15-17, 2023. For more information: primus.training

1. YouTube #golivetogether Feature Update - YouTube has announced that it's opening up its ‘Go Live Together (#golivetogether)' option to more users from next week, which will provide more creative considerations for your live-streams in the app.Go Live Together enables you to invite another YouTube user to your stream, with the video then displayed in vertical split-screen, providing new engagement and interaction options during a YouTube live broadcast. That could open up new opportunities for brands to run live interviews or internal spotlight sessions on their YouTube channel, while also facilitating Q and A sessions and other options to build engagement among your YouTube community. Hosts will be able to rotate the guest on their live-stream, but only one guest at a time will be able to take part in the broadcast.YouTube will also allow pre-roll, mid-roll, and post-roll ads on Go Live Together streams, which will be attributed to the host channel of the broadcast. YouTube says that all channels with at least 50 subscribers will soon be able to launch Live Together streams, with the roll-out beginning next week – though YouTube does note that it may take a few weeks to become available to all users.2. Instagram Subscriptions - Launched as a limited test back in January, subscriptions on Instagram are now available to all eligible US creators. Subscriptions allow creators to offer exclusive content in exchange for a recurring monthly payment from their followers. To see if you're eligible for Instagram Subscriptions, open the Instagram app and go to your professional dashboard. If you're eligible, you'll see an option to set up subscriptions for your account. With this feature activated, you can start posting subscriber-only: Live Streams  Stories  Badges  Posts  Reels  Group chats  Broadcast channels You can promote subscriptions in your Instagram stories with a dedicated sticker. When users tap on the sticker, they're taken to the subscription page. In addition to exclusive content, subscribers also get a special badge next to their name when commenting on posts.3. Facebook Professional Profile Is Now Available To All Users - Facebook's professional profile mode is now available to users worldwide, allowing everyone to showcase their skills and abilities. Facebook's “Professional Mode” is a profile setting that removes the need to create a Facebook Page to get your content in front of a larger audience. Also, you can now earn money from your Reels, or by enabling ads before, during, and after longer videos. Lastly, you can allow your fans to increase their support for you with a monthly subscription and share subscriber-only content. To learn more about Professional profile, click here.4. New UET Tag Dashboard In Microsoft Clarity - Understanding both user behavior and customer journey is crucial for successful marketing. To empower you with richer insights in a seamless experience, Microsoft launched Microsoft Clarity offering insights for Microsoft Advertising on Oct 18, 2021.  In hindsight, this is something I should have covered in Episode#79 and now regret skipping over the launch announcement.Anyways, Microsoft Clarity helps you better understand post-click user behavior and engagement on your landing pages because it's powered by the Universal Event Tracking (UET) tag that you place across your website. Now there's also a new UET tag dashboard which can help you monitor tag data and fix any issues that arise. This is a one-stop shop for all things UET, including real-time insights into the data that gets sent via UET tags and troubleshooting action recommendations.5. Microsoft Rolls Out Import Tool For Google Ads Performance Max - To simplify duplicating your efforts across platforms when using Google Ad's Performance Max campaigns, Microsoft Advertising has rolled out an update in their Google Import tool that allows advertisers to duplicate their Google Ads Performance Max campaigns.  Currently they only support Performance Max campaigns that use a Merchant center and will import the campaigns as Smart Shopping Campaigns and Local Inventory Ads. They have also started a pilot solution for importing your other Performance Max campaigns that aren't using the Merchant Center, starting with an experience that will import these campaigns as Search campaigns and create Dynamic Search Ads (DSA).Click here to learn more about on how to import your Performance Max campaigns in to Microsoft.6. Microsoft Ads Expands Availability Of ‘Similar Audiences' - If you're looking to expand your reach and find new potential customers, Similar Audiences automatically find new customers for you by looking for people who are similar to those in your remarketing lists. These audiences are generated automatically by Microsoft Advertising once you have a remarketing list in place. Similar Audiences can be used in the US and Canada, and the great news is that they're now generally available in more markets 7. Similar Audiences Is Going Away In Google Ads - Starting May 1, 2023, Google Ads will no longer generate similar audiences (also referred to as “similar segments”) for targeting and reporting. If you have active campaigns with similar segments, those will remain with your campaigns until August 1, 2023. After August 1, similar segments will be removed from all ad groups and campaigns. You'll continue to have access to historical reporting for similar segments from past campaigns. According to Google, In place of similar segments, different campaign types will offer different solutions to help you leverage your first-party data, reach the right audience, and improve campaign performance so that you can optimize directly for your business goals.If you have been using similar segments on Display, Discovery, or Video Action campaigns, and haven't yet turned on optimized targeting, you should turn on optimized targeting to reach additional relevant and expanded audiences and optimize for your conversion goals.If you have been using similar segments on Awareness and Reach video or Consideration video campaigns, you should include your first-party data segments in your ad groups, and turn on audience expansion to reach people similar to those in your first-party data.If you have been using similar segments on Search or Shopping campaigns and are not using Smart Bidding, you should use Smart Bidding with your campaigns. If you're using Smart Bidding already, or running Performance Max campaigns, you don't need to take any action, since Performance Max campaigns automatically leverage signals from your first-party data.8. Google Introduces New Search Labels For Coupons & Promos - According to a recent survey by Google, among Americans planning to shop for the holidays, 43% are planning to look for deals and sales more than last year. And Google is a central part of the shopping experience for US customers. On average, 60% say they've used Google properties for shopping in the past two days. To help searchers find the items they want at the best available prices, Google is updating shopping search results with new labels highlighting coupons and promotions and the ability to compare prices from multiple retailers.The promotion badge in search results on items that offer a discount using a coupon code, such as “15% off with coupon code HOLIDAYS.” Furthermore, a new coupon clipping feature lets searchers save promo codes for when they're ready to buy. This is similar to what Bing already has in-place for a while. A new deal comparison tool in Google search results makes it easier to view deals across retailers. For example, if you search for “women's puffer coat,” Google will display a side-by-side comparison of available deals in the SERPs.Lastly, Google's price insights feature is coming to search results to help shoppers make more informed buying decisions. Price insights allow you to see prices across merchants and whether the price is low or high based on historical values.If you are looking to tap into all the good things mentioned above then you need to make sure you are using structured data and Google Merchant Center. And don't forget you can always see how your deals are performing and review your business' promotions as well through Google Merchant Center. 9. Google: Search Console Verified Sites Do Not Get Crawled More - Google's John Mueller was asked if sites that are verified with Google Search Console get crawled more often or at a higher priority. The answer is no, "crawling is independent of Search Console," John said.Yes, you can use the URL Inspection tool to manually push URLs to be crawled faster but that is on a URL by URL basis and must be done mostly manually. Otherwise, just having a Search Console account won't lead to expedited crawling.10. Google: Don't Rely Only On Backlinks For Rankings - Backlinks (also known as “inbound links”, “incoming links” or “one way links”) are links from one website to a page on another website. Google and other major search engines consider backlinks “votes” for a specific page. Pages with a high number of backlinks tend to have high organic search engine rankings. And back in March 2016 during a Q&A session, Google's Andrey Lipattsev revealed that backlinks, content and RankBrain are the top three ranking signals in Google's search algorithm. Now Google's John Mueller says that in the future he can see a Google Search ranking algorithm where links are not as important in the overall algorithm as they are today. He also hinted that links are not weighted as much as they were in the history of the Google ranking algorithm. Here is what he had to say when asked about backlinks:“Well, it's something where I imagine, over time, the weight on the links. At some point, will drop off a little bit as we can't figure out a little bit better how the content fits in within the context of the whole web. And to some extent, links will always be something that we care about because we have to find pages somehow. It's like how do you find a page on the web without some reference to it? But my guess is over time, it won't be such a big factor as sometimes it is today. I think already, that's something that's been changing quite a bit”This is a similar message to what Google's head of search spam, Matt Cutts, said in a 2014 video that backlinks, over time, will become a little less important.My advice is that focus on writing better content and do not just rely on backlinks or else you will be in for a big surprise down the road.11. Google: Header Fonts Size Is Irrelevant For SEO - Google's John Mueller was asked "would google deem huge heading font size as a sign of "overdoing it", thus lower quality?" He said that the size of your header tags, i.e. H1s, H2s, etc, does not matter for SEO or ranking purposes. John said it might matter for users and conversions but for SEO, nope. Another SEO myth busted.12. Google: Stop Focusing On Writing Content Solely Based On Search Volume - Google's John Mueller said that if you make your content creation decisions based off of keyword search volume lists, then those pieces of content will be mediocre, at best. What John is saying is that if you are looking for content ideas and use base them on a list of keywords that show high search volume, then the content likely won't be good enough to rank well in Google Search. In short, write content that you can write something awesome about, and do not force your writing based on what people are searching for - especially if you don't know the topic super well.John added, "seeing a list like that as a target for content makes me worry that you're not going to get a lot out of your work, or that your work is going to be quite superficial." He said "I'd look for topics that match your expertise & passion. Where can you contribute that isn't already covered by lots of others, and do so in ways that provide something new & useful? Don't focus on keywords & "search volume" lists like this, they'll lead you into mediocracy."In my opinion, writing content solely on keyword volume is ridiculous. You should be writing your content on what your product, subject, or the market needs are and make it superior to your competitors.Also, if you peruse the Search Essentials document, you will find that Google advices you to: "Use words that people would use to look for your content, and place those words in prominent locations on the page, such as the title and main heading of a page, and other descriptive locations such as alt text and link text." To an untrained eye, it may come across as an implicit advice that you need to write content using keyword lists or research. However, what this means is that instead of creating content on those highly searched keywords, make content about topics you are an expert in and then sprinkle those highly searched keywords.Great Educational and Informative content -- not keywords -- always wins.13. Google: Your Website Doesn't Need 200k+Words To Be Authoritative - A Twitter user @natmiletic claimed that "You need around 200,000 words on your website to be considered authoritative by Google." John replied, "I don't know who made up that 200,000-word number, it's definitely not from Google."I'm including the screenshots just in case the user deletes his tweets.Remember that in 2019, John said word count is not a ranking factor and in 2018 John said word count is not indicative of quality. Google won't penalize you for short articles and Google said short articles can rank well and then again in 2014 said short articles are not low quality. Google has been recently advocating to avoid fluff . In addition, word count is not a sign of thin or how helpful content is or is not. In fact, Google even removed the reference to word count in the Search Console document recently.This goes to show that how much crap & myth is out there. Aren't you glad that you follow the #TWiMshow?

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! En esta segunda parte de la entrevista con la doctora Lucía Redondo seguimos hablando sobre el SIBO; comenzamos por el H2S, y luego hablamos sobre el sobrecrecimiento de Candida, cómo se debe actuar desde la Nutrición y qué hacer cuando se ha hecho de todo y no se consigue mejorar. Encuentras a la doctora Lucía Redondo en https://redondocuevas.es/ Las notas del episodio como siempre en https://slowmedicineinstitute.com/podcast/ Este episodio está patrocinado por el podcast Tabú Mental de Amazon Music: https://music.amazon.es/podcasts/4a0aa891-1b94-4eae-ae78-9e44546fca2f/tab%C3%BA-mental Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

Agradece a este podcast tantas horas de entretenimiento y disfruta de episodios exclusivos como éste. ¡Apóyale en iVoox! Un tema del que hasta ahora hemos hablado solamente en algunos episodios de preguntas y respuestas es el SIBO. Como es un tema que genera mucho interés, tenemos con nosotras a Lucía Redondo Cuevas, nutricionista y doctora en ciencias, y gran experta en SIBO. Esta es la primera parte de la entrevista, en la que hablamos sobre generalidades del SIBO y el IMO (el sobrecimiento de metanógenas). Profundizamos en SIBO de H2 y en IMO. En la segunda parte de la entrevista (la semana que viene) hablaremos sobre SIBO de H2S, dietas, y mucho más. Encuentras a la doctora Lucía Redondo en https://redondocuevas.es/ Las notas del episodio como siempre en https://slowmedicineinstitute.com/podcast/ Este episodio está patrocinado por el podcast Tabú Mental de Amazon Music: https://music.amazon.es/podcasts/4a0aa891-1b94-4eae-ae78-9e44546fca2f/tab%C3%BA-mental Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

This show dives into the history of H2S Scavengers and the work Q2 Technologies is doing to remove H2S and mercaptan in the Oil & Gas, Pulp & Paper, Wastewater, Landfill Gas, and Digester Biogas industries.We're bringing together the builders and innovators in energy in October 2022. Get your tickets for Fuze today: https://bit.ly/Fuze-OGS

Thank you to everyone who responded to the first episode about how to make clean, delicious natural wine. Your feedback was both encouraging and helpful. It became clear that there was a desire for this kind of information, and that there were things I needed to further explain from part 1.  This is a technical, detailed explanation of some of the important aspects of making wine naturally. If you haven't listened to part 1, this one will make a lot more sense if you do. Included in this part 2 episode are further discussions of optimal temperature and pH ranges for fermentation, everything you wanted to know about racking wine - when, how, how often, and why - and a comprehensive discussion of hydrogen sulfide (H2S) in wine and how to avoid and manage it, and many other aspects of natural winemaking.  Enjoy! Sponsor: https://www.centralaswine.com/

This month on Episode 38 of Discover CircRes, host Cynthia St. Hilaire highlights original research articles featured in the Jue 24th, July 8th and July 22nd issues of the journal. This episode also features an interview with the 2022 BCBS Outstanding Early Career Investigator Award finalists, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstadt.   Article highlights:   Nguyen, et al. miR-223 in Atherosclerosis.   Choi, et al. Mechanism for Piezo1-Mediated Lymphatic Sprouting   Kamtchum-Tatuene, et al.  Plasma Interleukin-6 and High-Risk Carotid Plaques   Li, et al. 3-MST Modulates BCAA Catabolism in HFrEF   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh. And today I'm going to be highlighting articles from our June 24th, July 8th and July 22nd issues of Circulation Research. I'm also going to have a chat with the finalists for the 2022 BCBS Outstanding Early Career Investigator Award, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstadt.   Cindy St. Hilaire:        The first article I want to share is from our June 24th issue and is titled, miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages. The first authors are My-Anh Nguyen and Huy-Dung Hoang, and the corresponding author is Katey Rayner and they're from the University of Ottawa. A combination of cholesterol accumulation in the blood vessels and subsequent chronic inflammation that's derived from this accumulation drive the progression of atherosclerosis. Unfortunately, current standard medications tackle just one of these factors, the cholesterol. And this might explain why many patients on such drugs still have vascular plaques. In considering treatments that work on both aspects of the disease, meaning lipid accumulation and inflammation, this group investigated the micro RNA 223 or miR-223, which is a small regulatory RNA that has been shown to suppress expression of genes involved in both cholesterol uptake and inflammatory pathways in both liver and immune cells.   Cindy St. Hilaire:        The team showed that mouse macrophages deficient in miR-223, exhibited increased expression of pro-inflammatory cytokines and reduced cholesterol efflux compared with control cells. Overexpression of miR-223 had the opposite effects. Furthermore, atherosclerosis prone mice, whose hematopoietic cells lacked miR-223, had worse atherosclerosis with larger plaques and higher levels of pro-inflammatory cytokines than to control animals with normal levels of miR-223. These findings highlight miR-223's dual prompt, antiatherogenic action, which could be leveraged for future therapies.   Cindy St. Hilaire:        The second article I want to share is from our July 8th issue of Circulation Research and is titled, Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymph Expansion. The first author is Dongwon Choi and the corresponding author is Young-Kwon Hong, and they're from UCLA.   As well as being super highways for immune cells, lymph vessels are drainage channels that help maintain fluid homeostasis in the tissues. This network of branching tubes grows as fluids begin to flow in the developing embryo. This fluid flow induces calcium influx into the lymphatic endothelial cells, which in turn promotes proliferation and migration of these cells, leading to the sprouting of lymph tubules. But how do LECs, the lymphatic endothelial cells, detect fluid flow in the first place? Piezo1 is a flow and mechanosensing protein known for its role in blood vessel development and certain mutations in Piezo1 cause abnormal lymphatic growth in humans.   Cindy St. Hilaire:        This script found that Piezo1 is expressed in the embryonic mouse LECs and that the suppression of Piezo1 inhibits both flow activated calcium entry via the channel ORAI1, as well as downstream target gene activation. Overexpression of Piezo1, by contrast, induced the target genes. The team went on to show that mice lacking either Piezo1 or ORAI1 had lymphatic sprouting defects and that pharmacological activation of Piezo1 in mice enhanced lymphogenesis and prevented edema after tail surgery. Together, the results confirmed Piezo1's role in flow dependent lymphatic growth and suggest it might be a target for treating lymphedema.   Cindy St. Hilaire:        The third article I want to share is also from our July 8th issue and is titled, Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability and Progression. The first and corresponding author of this study is Joseph Kamtchum-Tatuene from University of Alberta.   Excessive plasma cholesterol and systemic inflammation are contributing factors in atherosclerosis. While traditional remedies have been aimed at lowering patient's lipid levels, drugs that tackle inflammation are now under investigation, including those that suppress Interleukin-6, which is an inflammatory cytokine implicated in the disease. Focusing on carotid artery disease, this group conducted a prospective study to determine whether IL-6 levels correlated with disease severity. 4,334 individuals were enrolled in the cardiovascular health study cohort. They had their blood drawn and ultrasounds taken at the start of the study and five years later. This group found IL-6 was robustly correlated with and predicted plaque severity independent of other cardiovascular risk factors. This study also determined that an IL-6 blood plasma level of 2.0 picograms/mls, identified individuals with the highest likelihood of plaque, vulnerability and progression. This threshold value could be used to select patients who might benefit from novel IL-6 lowering medications.   Cindy St. Hilaire:        The last article I want to share is from our July 22nd issue of Circulation Research and is titled, Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure. The first author is Zhen Li, and the corresponding author is David Lefer from Louisiana State University. Hydrogen sulfide, or H2S, is a compound that exerts mitochondrial specific actions that include the preservation of oxidative phosphorylation, mitochondrial biogenesis and ATP synthesis, as well as inhibiting cell death. 3-mercaptopyruvate sulfurtransferase, or 3-MST, is a mitochondrial H2S producing enzyme, whose functions in cardiovascular disease are not fully understood.   Cindy St. Hilaire:        This group investigated the global effects of 3-MST deficiency in the setting of pressure overload induced heart failure. They found that 3-MST was significantly reduced in the myocardium of patients with heart failure, compared with non failing controls. 3-MST knockout mice exhibited increased accumulation of branch chain amino acids in the myocardium, which was associated with reduced myocardial respiration and ATP synthesis, exacerbated cardiac and vascular dysfunction, and worsened exercise performance, following transverse aortic constriction. Restoring myocardial branched-chain amino acid catabolism, or administration of a potent H2S donor, ameliorated the detrimental effects of 3-MST deficiency and heart failure with reduced injection fraction. These data suggest that 3-MST derived mitochondrial H2S, may play a regulatory role in branch chain amino acid catabolism, and mediate critical cardiovascular protection in heart failure.   Cindy St. Hilaire:        Today, I'm really excited to have our guests, who are the finalists for the BCVS Outstanding Early Career Investigator Awards. Welcome everyone.   Hisayuki Hashimoto:   Thank you.   Anja Karlstaedt:          Hi.   Hisayuki Hashimoto:   Hi.   Matthew DeBerge:      Hello. Thank you.   Cindy St. Hilaire:        So the finalists who are with me today are Dr Hisayuki Hashimoto from Keio University School of Medicine in Tokyo, Japan, Dr Matthew Deberge from Northwestern University in Chicago and Dr Anja Karlstaedt from Cedar Sinai Medical Center in LA. Thank you again. Congratulations. And I'm really excited to talk about your science.   Hisayuki Hashimoto:   Thank you. Yes. Thanks, first of all for this opportunity to join this really exciting group and to talk about myself and ourselves. I am Hisayuki Hashimoto, I'm from Tokyo, Japan. I actually learned my English... I went to an American school in a country called Zaire in Africa and also Paris, France because my father was a diplomat and I learned English there. After coming back to Japan, I went to medical school. During my first year of rotation, I was really interested in cardiology, so I decided to take a specialized course for cardiology. Then I got interested in basic science, so I took a PhD course, and that's what brought me to this cardiology cardiovascular research field.   Matthew DeBerge:      So I'm currently a research assistant professor at Northwestern University. I'm actually from the Chicagoland area, so I'm really excited to welcome you all to my hometown for the BCVS meeting.   Cindy St. Hilaire:        Oh, that's right. And AHA is also there too this year. So you'll see a lot of everybody.   Matthew DeBerge:      I guess I get the home field advantage, so to speak. So, I grew up here, I did my undergrad here, and then went out in the east coast, Dartmouth College in New Hampshire for my PhD training. And actually, I was a viral immunologist by training, so I did T cells. When I was looking for a postdoctoral position, I was looking for a little bit of something different and came across Dr Edward Thorpe's lab at Northwestern university, where the interest and the focus is macrophages in tissue repair after MI. So, got into the macrophages in the heart and have really enjoyed the studies here and have arisen as a research assistant professor now within the Thorpe lab. Now we're looking to transition my own independent trajectory. Kind of now looking beyond just the heart and focusing how cardiovascular disease affects other organs, including the brain. That's kind of where I'm starting to go now. Next is looking at the cardiovascular crosstalk with brain and how this influences neuroinflammation.   Anja Karlstaedt:          I am like Hisayuki, I'm also a medical doctor. I did my medical training and my PhD in Berlin at the Charité University Medicine in Berlin, which is a medical faculty from Humboldt University and Freie University. II got really interested in mathematical modeling of complex biological systems. And so I started doing my PhD around cardiac metabolism and that was a purely core and computationally based PhD. And while I was doing this, I got really hooked into metabolism. I wanted to do my own experiments to further advance the model, but also to study more in crosstalk cardiac metabolism. I joined Dr Heinrich Taegteyer lab at the University of Texas in the Texas Medical Center, and stayed there for a couple of years. And while I was discovering some of the very first interactions between leukemia cells and the heart, I decided I cannot stop. I cannot go back just after a year. I need to continue this project and need to get funding. And so after an AHA fellowship and NIHK99, I am now here at Cedars Sinai, an assistant professor in cardiology and also with a cross appointment at the cancer center and basically living the dream of doing translational research and working in cardio-oncology.   Cindy St. Hilaire:        Great. So, Dr Hashimoto, the title of your submission is, Cardiac Reprogramming Inducer ZNF281 is Indispensable for Heart Development by Interacting with Key Cardiac Transcriptional Factors. This is obviously focused on reprogramming, but why do we care about cardiac reprogramming and what exactly did you find about this inducer ZNF281?   Hisayuki Hashimoto:   Thank you for the question. So, I mean, as I said, I'm a cardiologist and I was always interested in working heart regeneration. At first, I was working with pluripotent stem cells derived cardiomyocyte, but then I changed my field during my postdoc into directly programming by making cardiomyocyte-like cells from fiberblast. But after working in that field, I kind of found that it was a very interesting field that we do artificially make a cardiomyocyte-like cell. But when I dissected the enhanced landscape, epigenetic analysis showed that there are very strong commonalities between cardiac reprogramming and heart development. So I thought that, hey, maybe we can use this as a tool to discover new networks of heart development. And the strength is that cardiac reprogramming in vitro assay hardly opens in vivo assay, so it's really time consuming. But using dark programming, we can save a lot of time and money to study the cardiac transitional networks. And we found this DNF281 from an unbiased screen, out of 1000 human open reading frames. And we found that this gene was a very strong cardiac reprogramming inducer, but there was no study reporting about any functioning heart development. We decided to study this gene in heart development, and we found out that it is an essential gene in heart development and we were kind of able to discover a new network in heart development.   Cindy St. Hilaire:        And you actually used, I think it was three different CRE drivers? Was that correct to study?   Hisayuki Hashimoto:   Ah, yes. Yeah.   Cindy St. Hilaire:        How did you pick those different drivers and what, I guess, cell population or progenitor cell population did those drivers target?   Hisayuki Hashimoto:   So I decided to use a mesodermal Cre-driver, which is a Mesp1Cre and a cardiac precursor Cre-driver, which is the Nkx2-5 Cre and the cardiomyocyte Cre, which is the Myh6-Cre. So three differentiation stages during heart development, and we found out that actually, DNF281 is an essential factor during mesodermal to cardiac precursor differentiation state. We're still trying to dig into the molecular mechanism, but at that stage, if the DNF281 is not there, we are not able to make up the heart.   Cindy St. Hilaire:        That is so interesting. Did you look at any of the strains that survived anyway? Did you look at any phenotypes that might present in adulthood? Is there anything where the various strains might have survived, but then there's a kind of longer-term disease implicating phenotype that's observed.   Hisayuki Hashimoto:   Well, thank you for the question. Actually, the mesodermal Cre-driver knocking out the DNF281 in that stage is embryonic lethal, and it does make different congenital heart disease. And they cannot survive until after embryonic day 14.5. The later stage Nkx2-5 Cre and Myh6-Cre, interestingly, they do survive after birth. And then in adult stage, I did also look into the tissues, but the heart is functioning normally. I haven't stressed them, but they develop and they're alive after one year. It looks like there's really no like phenotype at like the homeostatic status.   Cindy St. Hilaire:        Interesting. So it's kind of like, once they get over that developmental hump, they're okay.   Hisayuki Hashimoto:   Exactly. That might also give us an answer. What kind of network is important for cardiac reprogramming?   Cindy St. Hilaire:        So what are you going to do next?   Hisayuki Hashimoto:   Thank you. I'm actually trying to dig into the transitional network of what kind of cardiac transitional network the ZNF281 is interacting with, so that maybe I can find a new answer to any etiology of congenital heart disease, because even from a single gene, different mutation, different variants arise different phenotypes in congenital heart disease. Maybe if I find a new interaction with any key cardiac transitional factors, maybe I could find a new etiology of congenital heart disease phenotype.   Cindy St. Hilaire:        That would be wonderful. Well, best of luck with that. Congratulations on an excellent study. Hisayuki Hashimoto:   Thank you.   Cindy St. Hilaire:        Dr DeBerge, your study was titled, Unbiased Discovery of Allograft Inflammatory Factor-1 as a New and Critical Immuno Metabolic Regulatory Node During Cardiac Injury. Congrats on this very cool study. You were really kind of focused on macrophages in myocardial infarction. And macrophages, they're a Jeckel Hyde kind of cell, right? They're good. They're bad. They can be both, almost at the same time, sometimes it seems like. So why were you interested in macrophages particularly in myocardial infarction, and what did you discover about this allograft inflammatory factor-1, or AIF1 protein?   Matthew DeBerge:      Thank you. That's the great question. You really kind of alluded to why we're interested in macrophages in the heart after tissue repair. I mean, they really are the central mediators at both pro-inflammatory and anti-inflammatory responses after myocardial infarction. Decades of research before this have shown that inflammation has increased acutely after MI and has also increased in heart failure patients, which really has led to the development of clinical efforts to target inflammatory mediators after MI. Now, unfortunately, the results to target inflammation after MI, thus far, have been modest or disappointing, I guess, at worst, in the respect that broadly targeting macrophage function, again, hasn't achieved results. Again, because these cells have both pro and anti-inflammatory functions and targeting specific mediators has been somewhat effective, but really hasn't achieved the results we want to see.   Matthew DeBerge:      I think what we've learned is that the key, I guess, the targeting macrophage after MI, is really to target their specific function. And this led us to sort of pursue novel proteins that are mediating macrophage factor function after MI. To accomplish this, we similarly performed an unbiased screen collecting peri-infarct tissue from a patient that was undergoing heart transplantation for end stage heart failure and had suffered an MI years previously. And this led to the discovery of allograft inflammatory factor-1, or AIF1, specifically within cardiac macrophages compared to other cardiac cell clusters from our specimen. And following up with this with post-mortem specimens after acute MI to show that AIF1 was specifically increased in macrophages after MI and then subsequently then testing causality with both murine model of permanent inclusion MI, as well as in vitro studies using bone marrow drive macrophages to dig deeper mechanistically, we found that AIF1 was crucial in regulating inflammatory programing macrophages, which ultimately culminated in worse in cardiac repair after MI.   Cindy St. Hilaire:        That's really interesting. And I love how you start with the human and then figure out what the heck it's doing in the human. And one of the things you ended up doing in the mouse was knocking out this protein AIF1, specifically in macrophage cells or cells that make the macrophage lineage. But is this factor in other cells? I was reading, it can be intracellular, it can be secreted. Are there perhaps other things that are also going on outside of the macrophage?   Matthew DeBerge:      It's a great question. First, I guess in terms of specificity, within the hematopoietic compartment, previous studies, as well as publicly available databases, have shown that AIF1 is really predominantly expressed within macrophages. We were able to leverage bone marrow chimera mice to isolate this defect to the deficiency to macrophages. But you do bring up a great point that other studies have shown that AIF1 may be expressed in other radio-resistant cell populations. I mean, such as cardiomyocytes or other treatable cells within the heart. We can't completely rule out a role for AIF1 and other cell populations. I can tell you that we did do the whole body knockout complementary to our bone marrow hematopoetic deficient knockouts, and saw that deficiency of AIF1 within the whole animal, recapitulate the effects we saw within the AIF1 deficiency within hematopoietic department.   Matthew DeBerge:      It was encouraging to us that, again, the overall role of AIF1 is pro-inflammatory after MI.   Cindy St. Hilaire:        I mean, I know it's early days, but is there a hint of any translational potential of these findings or of this protein?   Matthew DeBerge:      Yeah, I think so. To answer your question, we were fortunate enough to be able to partner with Ionis that develops these anti-sensible nucleotides so that we could specifically target AIF1 after the acute phase during MI. We saw that utilizing these anti-sensible nucleotides to deplete AIF1, again, within the whole mouse, that we were able to reduce inflammation, reduce in heart size and preserve stock function. I think there really is, hopefully a therapeutic opportunity here. And again, with it being, perhaps macrophage specific is, even much more important as we think about targeting the specific function of these cells within the heart.   Cindy St. Hilaire:        Very cool stuff. Dr Karlstaedt, the title of your submission is, ATP Dependent Citrate Lyase Drives Metabolic Remodeling in the Heart During Cancer. So this I found was really interesting because you were talking about, the two major killers in the world, right? Cardiovascular disease and cancer, and you're just going to tackle both of them, which I love. So obviously this is built on a lot of prior observations about the effects of cancer on cardiac metabolic remodeling. Can you maybe just tell us a little bit about what is that link that was there and what was known before you started?   Anja Karlstaedt:          Yeah. Happy to take that question. I think it's a very important one and I'm not sure if I will have a comprehensive answer to this, because like I mentioned at the beginning, cardio-oncology is a very new field. And the reason why we are starting to be more aware of cancer patients and their specific cardiovascular problems is because the cancer field has done such a great job of developing all these new therapeutics. And we have far more options of treating patients with various different types of cancers in particular, also leukemias, but also solid tumors. And what has that led to is an understanding that patients survive the tumors, but then 10, 20 years later, are dying of cardiovascular diseases. Those are particular cardiomyopathies and congestive heart failure patients. What we are trying, or what my lab is trying to do, is understanding what is driving this remodeling. And is there a way that we can develop therapies that can basically, at the beginning of the therapy, protect the heart so that this remodeling does not happen, or it is not as severe.   Anja Karlstaedt:          Also, identifying patients that are at risk, because not every tumor is created equally and tumors are very heterogeneous, even within the same group. To get to your question, what we found is, in collaboration actually with a group at Baylor College of Medicine, Peggy Goodell's group, who is primarily working on myeloid malignancies, is that certain types of leukemias are associated with cardiomyopathies. And so when they were focusing on the understanding drivers of leukemia, they noticed that the hearts of these animals in their murine models are enlarged on and actually developing cardiomyopathies. And I joined this project just very early on during my postdoc, which was very fortunate and I feel very lucky of having met them. What my lab is now studying here at Cedars is how basically those physiological stress and mutations coming from the tumors are leading to metabolic dysregulation in the heart and then eventually disease.   Anja Karlstaedt:          And we really think that metabolism is at the center of those disease progressions and also, because it's at the center, it should be part of the solution. We can use it as a way to identify patients that are at risk, but also potentially develop new therapies. And what was really striking for us is that when we knock down ACLY that in a willdtype heart where the mouse doesn't have any tumor disease, ACLY actually is critically important for energy substrate metabolism, which seems counterintuitive, because it's far away from the mitochondria, it's not part of directly ADP provision. It's not part of the Kreb cycle. But what we found is that when we knock it out using a CRISPR-Cas9 model, it leads to cardiomyopathy and critically disrupts energy substrate metabolism. And that is not necessarily the case when the mouse has leukemia or has a colorectal cancer, which upregulated in the beginning, this enzyme expression. And so we have now developed models that show us that this could be potentially also therapeutic target to disrupt the adverse remodeling by the tumor.   Cindy St. Hilaire:        That is so interesting. So one of the things I was thinking about too is we know that, I mean, your study is showing that, the tumor itself is causing cardiac remodeling, but we also know therapies, right? Radiation, chemotherapy, probably some immune modulatory compounds. Those probably do similar, maybe not exactly similar, but they also cause, adverse cardiac remodeling. Do you have any insights as to what is same and what is different between tumor driven and therapy driven adverse remodeling?   Anja Karlstaedt:          So we do not know a lot yet. It's still an open question about all the different types of chemotherapeutics, how they are leading to cardio toxicities. But what we know, at least from the classic anti-cyclic treatments, is right now at the core, the knowledge is that this is primarily disrupting cardiac mitochondrial function. And through that again, impairing energy provision and the interaction, again, with the immune system is fairly unknown, but we know through studies from Kathryn Moore and some very interesting work by Rimson is that myocardial infarction itself can lead to an increase in risk for tumor progression. And what they have shown as independent of each other, is that the activation of the immune system in itself can lead to an acceleration of both diseases, both the cardiac remodeling, and then also the tumor disease. We don't fully understand which drivers are involved, but we do know that a lot of the cardiomyopathies on cardiotoxicities that are chemotherapeutically driven, all have also metabolic component.   Cindy St. Hilaire:        Nice. Thank you. When I prepare for these interviews, I obviously read the abstracts for the papers, but I found myself also Googling other things after I read each of your abstracts. It was a rabbit hole of science, which was really exciting.                               I now want to transition to kind of a career angle. You all are obviously quite successful, scientifically, at the bench, right? But now you are pivoting to a kind of completely opposite slash new job, right? That of, independent researcher. I would love to hear from each of you, if there was any interesting challenge that you kind of overcame that you grew from, or if there was any bit of advice that you wish you knew ahead of time or anything like that, that some of our trainee listeners and actually frankly, faculty who can pass that information onto their trainees, can benefit from.   Anja Karlstaedt:          I think the biggest challenge for me in transitioning was actually the pandemic. Because I don't know how it was for Hisa and Matt, but trying to establish a lab, but also applying for faculty position during a major global pandemic, is challenging is not quite something that I expected that would happen. And so I think saying that and looking more conceptually and philosophically at this as, you can prepare as much as you want, but then when life just kicks in and things happen, they do happen. And I think the best is to prepare as much as you can. And then simply go with the flow. Sometimes one of my mentors, Dave Nikon, mentioned that to me when I was applying for faculty positions, it's sometimes good to just go with the flow. And as a metabolism person, I absolutely agree. And there are some things that you can do as a junior investigator.   Anja Karlstaedt:          We need to have a good network. So just very important to have good mentors. I was blessed with have those mentors, Peggy Goodell's one of them, Heinrich Taegtmeyer was another. And now with this study that we are publishing, Jim Martin and Dave Nikon were incredible. Without them, this study wouldn't have been possible and I would not be here at Cedars.   Anja Karlstaedt:          You need to reach out to other people because those mentors have the experience. They have been through some of this before. Even if they have never had a major event, like COVID-19 in their life before, because none of us had before, they had other experiences and you can rely on them and they set you then up for overcoming these challenges. And the other thing I would say, is put yourself out there, go and talk to as many people as possible or set conferences, present a poster, not only talks. Don't be disappointed if you don't get a talk, posters are really great to build this network and find other people that you probably wouldn't have encountered and apply for funding. Just again, put yourself out there and try to get the funding for your research. Even if it's small foundations, it builds up over time and it is a good practice to then write those more competitive grants.     Cindy St. Hilaire:        Dr Hashimoto, would you like to go next?   Hisayuki Hashimoto:   Just my advice is that, could be like a culture of difference, but in east Asia, like in Japan, we were taught to, do not disturb people, don't interrupt people and help people. But I realized that I wasn't really good at asking for help. After I am still not like fully independent, but I do have my own group and I have to do grant writing. I still work at the bench and then have to teach grad students, doing everything myself. I just realized it's just impossible. I didn't have time. I need like 48 hours a day. Otherwise, you won't finish it. I just realized that I wasn't really good at asking for help. So my advice would be, don't hesitate to ask for help. It's not a shame. You can't do everything by just yourself. I think, even from the postdoc, even from grad school, I think, ask for help and then get used to that. And then of course, help others. And that is the way I think to probably not get overwhelmed and not stress yourself. Science should be something fun. And if you don't ask for help and if you don't help someone, I think you are losing the chance of getting some fun part from the science.   Cindy St. Hilaire:        That's great advice. I really like that, especially because I find at least, I started my lab seven years ago now. And I remember the first couple months/year, it was extremely hard to let go, right? Like I taught my new people how to do the primary cell culture we needed, but I was terrified of them doing it wrong or wasting money or making too many mistakes. But you realize, you got to learn to trust people. Like you said, you got to learn to ask for help. And sometimes that help is letting them do it. And you doing, you're being paid now to write grants and papers. That's a big brain, you're not paid to do the smaller things. That's really great advice. I like that. Thank you. Dr DeBerge, how about you?   Matthew DeBerge:      So I guess towards a bit of life advice, I think two obvious things is one, be kind, science is hard enough as it is. So I think we should try to lift each other up and not knock each other down. And along those lines as the others have alluded to as well, one of the mantras we sort of adapted on the lab, is a rising tide raises all ships, this idea that we can work together to elevate each other's science and really, again, collaborate.   Towards the career side of things I'll just touch on, because I guess one thing I'll add, there's more than one path, I guess, to achieving your goals. I've been fortunate enough to have an NIH post-doctoral fellowship and had an AHA career development award, but I'm not a K99 recipient. Oftentimes, I think this is the golden ticket to getting the faculty job, so I'm trying to, I guess, buck trend, I just submitted an RO1. So fingers crossed that leads to some opportunity.   Even beyond academia, I'm not certain how much everyone here is involved in science Twitter, it's really become a thing over the last couple years, but I think, kind of the elephant in the room is that academia, it's really hard on the trainees nowadays to have a living wage, to go through this. I mean, I'm really excited to see my, fellow finalists here are starting their own groups and stuff, but for many, that's not the reality for many, it's just not financially feasible. So I think, kind of keeping in mind that there's many, many alternative careers, whether it's industry, whether it's consulting, science writing, etcetera, going back to what Dr Hash says, find what you love and really pursue that with passion.   Cindy St. Hilaire:        I think it's something only, I don't know, five to 10% of people go into or rather stay in academia. And that means, 90 to 95% of our trainees, we need to prepare them for other opportunities, which I think is exciting, because it means it can expand our network for those of us in academia.   Anja Karlstaedt:          I think right now it's even worse because it's about 2% of old postdocs that are actually staying and becoming independent researchers, independent or tenure track or research track. And I think I second, as what Matt said, because I play cello. I do music as a hobby and people always ask me if I'm a musician. And at the beginning I felt like, no, of course not. I'm not like Yoyo Ma. I'm just playing, it's a hobby. And then I, that got me thinking. I was like, no, of course you are because there's so many different types. And what we need to understand is that scientists, like you are always a scientist. It doesn't matter if you are working at Pfizer or if you are working at a small undergrad institution and you're teaching those next generation scientists, you are still scientist and we all need those different types of scientists because otherwise, if everybody is just a soloist, you are never going to listen to symphony. You need those different people and what we need to normalize beyond having those different career paths, is also that people are staying in academia and becoming those really incredible resources for the institutions and labs, quite frankly, of being able to retain those technologies and techniques within an institution. And I think that's something to also look forward to, that even if you're not the PI necessarily, you're the one who is driving those projects. And I hope to pass this on at some point also to my trainees that they can be a scientist, even if they're not running a lab and they become an Institute director and that's also critically important.   Cindy St. Hilaire:        There's lots of ways to do science. Thank you all so much for joining me today. Either waking up at 5:00 AM or staying up past midnight, I think it is now in Japan or close to it. So Matt and I kind of made it out okay. It's like 8:00 or 9:00 AM.   Matthew DeBerge:      Thank you.   Hisayuki Hashimoto:   My apologies for this time zone difference.   Cindy St. Hilaire:        I'm very glad to make it work. Congratulations to all of you, your presentations. I forget which day of the week they are on at BCVS, but we are looking forward to the oral presentations of these and congratulations to all of you. You are amazing scientists and I know I'm really looking forward to seeing your future work so best of luck.   Matthew DeBerge:      Thank you.   Hisayuki Hashimoto:   Thank you.   Anja Karlstaedt:          Thank you so much.   Cindy St. Hilaire:        That's it for the highlights from the June 24th, July 8th and July 22nd issues of Circulation Research. Thank you for listening. Please check out the CircRes Facebook page and follow us on Twitter and Instagram with the handle at CircRes and hashtag Discover CircRes. Thank you to our guests. The BCVS Outstanding Early Career Investigator Award Finalists, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstaedt. This podcast is produced by Ashara Ratnayaka, edited by Melissa Stoner and supported by the editorial team of Circulation Research. Some of the copy text for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire. And this is Discover CircRes, you're on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information visit ahajournals.org.  

We're taking a trip back to high school chemistry in this episode! The chemical compound H2S, better known as the gaseous chemical Hydrogen Sulfide--the one that puts off a "rotten eggs" smell, is found in many natural environment settings. However, did you know that Hydrogen Sulfide is produced in small amounts in our bodies? This over-looked compound has a variety of important physiological effects, especially as we age. Dr. Chris Hine has been studying these benefits and how H2S may actually help stave off Glioblastoma (GBM)! Both Dr.'s Hine and Lathia have been hard at work at the Lerner Research Institute at Cleveland Clinic finding out-of-the-box ways to better treat or help prevent brain cancers such as GBM. In this episode, we take a deeper look into their work. Season Presenting Sponsor: Gamma Tile (GT Medical Technologies)   Episode Sponsors: OncoSynergy, Inc. & Highmark BCBS of WNY

Redshift gives a masterclass on how they're using plasma to dissociate H2S molecules to produce hydrogen—taking a waste product in refineries and turning it into a useful product!https://www.rsenrg.com/https://www.linkedin.com/in/howard-nelson-3964161/https://www.linkedin.com/in/trey-anthony-1823424/

 So, before we get started today, I wanted to let you know that I'm currently off on annual leave, one of my goals this year was to take more time off – well, to basically time off, rather than working through until Christmas!  And so, the episode you're hearing today is a replay of a past episode. As it's IBS Awareness Month, and because so many of us with endo have IBS, I wanted to share with you my most foundational, actionable and informative episodes on endo belly, IBS and SIBO – so every week you'll get two episodes on this theme, to help raise awareness and to provide you with some actions. Now because these episodes are old, I may not refer to some of the resources I provide on the endo belly, so I wanted to remind you of the services I provide. So, to start with, I have plenty of other episodes on the endo belly, I have a course called The Endo Belly Course which is specifically for anyone with endo who really struggles with IBS, endo belly or SIBO (here's the waitlist; I work with 1 to 1 clients; especially those with endo belly or SIBO, and I have lots and lots of articles on Endometriosis News and Endometriosis Net about these topics. And of course, I also   have my Instagram account, which is chock full of SIBO and endo belly info, for those of you wanting to learn more. Lastly, if you feel you need a little extra support, I am currently running a free Endo Belly Challenge. The challenge ends on April 18th, but if you sign up before May 2nd, you'll still be able to access all of the challenge, and catch up – and for anyone who takes part, you'll be invited to a private, free Q&A call with me at the start of May, where you'll get to ask me all your endo belly questions. Okay, so without further ado, let's get to the episode: It's finally here! The long awaited episode on how to test for SIBO. Many of you have been contacting me to ask how to get tested or whether you can test at home, so here's my episode discussing all the ins and outs. Here's a breakdown of some of the key points in the episode: Hydrogen and methane type SIBO can be detected through a SIBO breath test. You can order at-home kits. In my experience, most GPs won't/can't order SIBO breath tests and aren't familiar with it, though GI doctors may be able to and SIBO specialist doctors certainly can. A SIBO breath test involves drinking a solution of glucose or lactulose and breathing into a test tube for 2-3 hours. The substrate will feed the bacteria, which will create fermentation, and the gas is then collected in the test tube and measured in the lab in parts per million. Tests can be either 2 hours with 8 test tubes or 3 hours with 10 test tubes. 2 hours runs the risk of missing SIBO in a person with slow gut motility, so for that reason, I prefer to go with a 3 hour test. Some specialists prefer testing with glucose, others lactulose. I like to use lactulose as glucose is absorbed in the first 1-3 feet of the small intestine and the small intestine is on average 22 ft long! So if the SIBO is further down, a glucose test can miss it entirely. A prep diet and overnight fast is required before taking the test. This is a low to no carb diet of meat, fish, eggs, black tea or coffee. There are some allowances for vegans, vegetarians or diabetics. If a patient ate too many carbs, or did the prep test incorrectly it would skew the test results and the test would need to be redone. The North American breath testing consensus states that a positive for hydrogen would be a rise of 20 ppm or more (parts per million) from the baseline (the breath before drinking the solution) in the first 90 minutes. A positive for methane would be 10ppm or more in the whole 180 minutes, including the baseline. Dr Allison Siebecker, who I trained with, has a slightly different diagnostic range after years and years of working with SIBO clients and consulting with other SIBO specialists. A positive hydrogen for her would be 20ppm in the first 120 minutes, with no rise needed as long as the baseline isn't the highest number. Methane is 10 within 180 but if constipation was present, the methane would be positive if the reading was 3-9ppm. Though hydrogen sulfide SIBO cannot be detected with this test, some H2S patients have a flat line pattern that indicates the presence of H2S. This would be a result of 6ppm or less for hydrogen and 3ppm or less for methane. An elevated baseline (so not 0) is normal for methane. In the USA, lactulose requires a prescription so you would need to find a doctor who could help you order it. For a deeper dive and my breakdown on how to take the test itself, have a listen to the show! I really hope this episode helps those of you who are suspecting that SIBO may be the culprit behind your endobelly. Let's get social! Come say hello on Instagram or sign up to my newsletter. Sign up to The Endo Belly Course wait list here.  On March 28th I am running my second Endo Belly Challenge! In this 4-week challenge, you will learn the first steps to identifying the root causes of your endo belly and the initial tools to heal your swelling, gut issues and abdominal discomfort. Every Monday, you'll receive a new email with a little bit of endo belly education and an action to implement that week! This challenge is perfect for anyone who experiences abdominal swelling/bloating, gas, constipation, nausea, diarrhea/loose stools, acid reflux, indigestion or stomach cramps with their endometriosis - and it's entirely free. You can sign up here. My cookbook This EndoLife, It Starts with Breakfast is out now! Get 28 anti-inflammatory, hormone friendly recipes for living and thriving with endometriosis. Order your copy here. If you feel like you need more support with managing endometriosis, you can join Your EndoLife Coaching Programme. A 1-to-1 three month health and life coaching programme to help you thrive with endometriosis. To find out more about the programme and to discuss whether it could be right for you, email me at hello@thisendolife.com or visit my website. This episode is produced by Ora Podcasts. Ora provides audio editing, management and other services to make podcasting simple and sustainable for their clients. Health coaches, nutritionists, mediums, personal trainers, tarot readers, teachers, or just those striving for a better world, Ora can help you start and maintain your podcast. Get in touch today. This episode is sponsored by BeYou. Soothe period cramps the natural way with these 100% natural and discreet menthol and eucalyptus oil stick on patches and CBD range. Click here to find out more and to shop: https://beyouonline.co.uk This episode is sponsored by Semaine. Try their supplement for period pain and daily supplement for hormonal balance and PMS prevention with code ENDOLIFE to get 20% off your first order.

The Structural Epoxy System for sanitary sewer manholes provides the one of strongest epoxy-based manhole rehabilitation and lining systems available in the market. Often specified for manhole rehab projects, the system is also terrific for lining newly installed structures when high head pressure or high H2S is anticipated. The system's primary technology is a high build, fiber reinforced polymer epoxy. Categorized as an FRP, this Epoxytec system is the highest build liner and carries the best warranty offering within the Epoxytec portfolio when applied by Certified Applicators.

The Structural Epoxy System for sanitary sewer manholes provides the one of strongest epoxy-based manhole rehabilitation and lining systems available in the market. Often specified for manhole rehab projects, the system is also terrific for lining newly installed structures when high head pressure or high H2S is anticipated. The system's primary technology is a high build, fiber reinforced polymer epoxy. Categorized as an FRP, this Epoxytec system is the highest build liner and carries the best warranty offering within the Epoxytec portfolio when applied by Certified Applicators.

Have you ever experienced mood dysregulation ? Did you know that the inhalation of H2S can correct depressive-like behaviors in rats? Why meditation results in feelings of calmness, relaxation, and even euphoria? In this new episode of Chemocast, we're digging into the science behind chemotransmitters.

Does farting mean that I'm unhealthy...?NO! Everyone farts! Even the healthiest people.But.... not all farts are equal! You probably had a sense (or smell) of that.Also, some flatulence is associated with excessive bloating, GI cramping, and irregular bowel habits - not very pleasant symptoms that could indicate imbalances in the digestive system.Here in this episode, we intend to distinguish normal, healthy gas from the more pathologic and problematic gas while also giving you some tips, tricks, and guidance for dealing with gas as you keep optimizing your digestive health.If you'd like to join these conversations live, be sure to Subscribe to the Alter Health YouTube Channel! https://www.youtube.com/alterhealthSome highlights from today's MM episode...Gas is the byproduct of fermentation in the gut, a natural part of the digestive processDifferent plant fibers (carbohydrates) fuel the various strains of microbes inhabiting the gut - which in tern give us SCFAs (postbiotics -  acetate, propionate, and butyrate)Microbial breakdown of protein (amino acids) creates a whole bunch of other end products (amines, phenols, indoles, thiols, CO2, H2, and H2S) many of which have toxic propertiesProteins takes longer to digest and can contribute to a slower GI transit time (time it takes for foods to pass from mouth to toilet) - 12-24 hours is healthy, 48-96 hours is “normal”Fiber, hydration, movement, relaxation/peace helps optimize transitA main cause of foul smelling farts is protein putrification which takes place in the context of high protein diets and a slowed transit timeFiber-rich carbohydrate diets diversity the microbiome and lead to enhanced SCFA production which is protective against GI disorders and other chronic diseases.Tips for relieving gas - carminative herbs, digestive bitters, food hygiene...Links to some more good stuff-  Join Alter Health on Locals: https://alterhealth.locals.com/- Cleanse with Us during the next Alter Health Cleanse: https://www.alter.health/cleanse- Work with us in the Thrive on Plants program: https://www.alter.health/thrive-on-plants- ATTN Health Practitioners! Learn more and apply to the Plant Based Mind Body Practitioner Program: https://www.alter.health/pbmb-practitionerPeace and Love.

We've got a special episode for you today. Erin sits down with Dr. Mark Pimentel, researcher, clinician, and cofounder of Gemelli Biotech™, to discuss the latest research on IBS, SIBO, and new testing options for people who have struggled with these conditions. This is definitely a higher level podcast interview, so this episode is great for clinicians, practitioners, anyone who loves to geek out on gut health and research, or anyone who's been struggling with IBS or SIBO and looking for answers. Erin and Mark discuss leading causes of IBS, the overlap of IBS & SIBO, why patients are often being dismissed in other practices, how the blood tests and breath tests for diagnosing these conditions work, why the treatment strategies are nuanced, and much more. What makes Dr. Mark Pimentel's insights noteworthy is he's not just a researcher; he's also a clinician, and it's the process of taking that information and applying it to humans where we learn so much. This is an episode you'll want to refer back to - share with someone who could use this information! In this episode: -Why today's guest is particularly noteworthy [1:08] -Why Mark Pimentel continues his research [8:42] -What is the leading cause of IBS? [10:37] -The value behind the ibs-smart™ blood test [13:32] -Inferring antibody patterns in post-infectious IBS [16:23] -New research that debunks two widely accepted concepts about SIBO [21:41] -The overlap between post-infectious IBS and SIBO [23:26] -New info on PPI (proton pump inhibitor) use and SIBO [27:45] -The potential problem with akkermansia as a probiotic supplement & other single-organism treatments [30:43] -How does Intermittent Fasting or fluid affect the migrating motor complex & should these strategies be considered for IBS? [37:28] -Hydrogen sulfide and the trio-smart® breath test for SIBO [39:18] -How treatment differs for hydrogen-dominant SIBO (SIBO-D), Intestinal Methanogen Overgrowth (IMO) & hydrogen sulfide SIBO (H2S SIBO) [45:25] -Does constipation with H2S occur? [48:55] -The various types of bacteria that produce hydrogen gas [51:02] -The mechanism of action of lovastatin as future treatment for methane in constipation [53:26] -Using prokinetics for low motility [55:35] -Pimentel's thoughts on the low FODMAP diet [56:56] FOR OUR FULL LIST OF LINKS + RESOURCES, HEAD TO: https://www.erinholthealth.com/funktional-nutrition-podcast/2021/11/16/episode-181-sibo-amp-ibs-the-latest-research-amp-testing-options-with-dr-mark-pimentel

#230 Dr. Allison Siebecker is a professor of Advanced Gastroenterology, an international lecturer, researcher, award-winning author, and the 2021 lifetime achievement Borborygmus award recipient from the Gastroenterology Association of Naturopathic Physicians. Dr. Siebecker has specialized in SIBO since 2010, is a SIBO patient herself, and is a pioneer of integrative SIBO treatments and education, including her free educational website siboinfo.com In this episode we cover New Hydrogen Sulphide Research - including testing, symptom picture, treatment etc Hydrogen Sulphide research Allison's thoughts on the title Intestinal Methanogen Overgrowth versus methane SIBO The link between mould and tough cases of SIBO We discuss biofilm disruptors - are we using the correct ones? and so much more   Show notes  Join me for the Next Steps for Treating Tough SIBO Masterclass Summit  The SIBO Recovery Roadmap for patients The SIBO Pro Course for practitioners H2S SIBO Registry (please submit your H2S cases here for research) Biofilm Phase-2 Enhanced Free Webinar by Dr. Anderson  

In todays episode Adrian Lawrence FCA talks about the UK Construction sector and FD recruitment. The Construction sector is a key part if the UK economy and employs several million people. There are many large and high profile projects underway such as the Cross Rail link and others in prospect such as the expansion of Heathrow and Gatwick airports not to mention the H2S high speed rail link project. FD Capital Recruitment is running an interest FD role at present in North London and we regularly pick up Construction sector FD roles. If you are a candidate looking for a senior opportunity or a business looking for a new Finance Director make sure to reach out to team today via our website at https://www.fdcapital.co.uk

Writing SEO content is very different from writing content for social media or other platforms. Your goal in writing SEO content is to attract visitors to your blog, to your website, and to actually rank on Google. There should be a conscious effort to understand how users will behave on your site, what they need, and how fast they got what they are searching for. Ultimately, it boils down to making visitors happy.   Podcast Highlights: 00:00 Prologue 00:42 Introduction of the topic  00:55 Understanding what Google wants to show users in their search results. 02:05 Tools that you can use to help in writing SEO content. 02:47 A good headline and meta title are necessary to draw attention to your article. (...What is the difference between Headline One and the Meta Title?) 04:41 Why are subheadlines (H2s) equally important? 07:33 The importance of monitoring your published article with Google Analytics.  07:52 Other tools that can track and collect data on the scrolls people do in your article. 08:37 Recap 09:40 End Resources: Tools mentioned by Gert Mellak: InLinks - https://inlinks.net/ Surfer SEO - https://surferseo.com/ Hotjar - https://www.hotjar.com/ Crazy Eggs - https://www.crazyegg.com/   Connect with Gert Mellak: Website: https://seoleverage.com/ Email: info@seoleverage.com

Do you have endometriosis and struggle with the ‘endo belly’? Do you have fatigue and brain fog? Maybe you have other unusual symptoms like swelling or puffiness, rashes or skin conditions like eczema or rosacea. If any of these sound familiar, you may not just be dealing with endo alone. I’ve only ever done one other client story, but judging by the number of downloads, you guys found it helpful so I thought I’d share another! This is Sophie’s story of treating SIBO, candida and histamine intolerance whilst living with endo. I wanted to share Sophie’s story because her case is complex and her healing path hasn’t been easy or linear, and so for those of you who are struggling right now or feel overwhelmed by the idea of taking on SIBO, I think you’ll find Sophie’s experience, her hope, her patience and her perseverance inspiring. Sophie came to me due to her painful sex symptoms, bloating and histamine reactions. We quickly discussed that severe SIBO was at the root of most of her issues (the painful sex we also addressed with pelvic floor physiotherapy and other strategies) and so Sophie began treatment early on into our coaching. Her treatment was a great success and she was negative for hydrogen and methane by the end of it, yet was still having some bloating symptoms and histamine symptoms. Her test results following her treatment showed a flat line, so the question was has the elemental diet really just wiped everything out, or is hydrogen sulphide at play here? In the UK we don’t have testing for hydrogen sulphide, so deciding whether to treat that is down to the presence of H2S symptoms. We consulted Dr Alison Siebecker, who agreed that it was a tough one to call but suggested we consider trying some hydrogen sulphide treatment to see whether it helped. What we observed from this treatment was severe die off, an inflammatory reaction that occurs when bacteria, fungus or viruses die, and it can cause a flare up of symptoms. Something was dying, but it was a struggle for Sophie to continue through with the symptoms. We added in die off strategies and tried different treatment options, but even after treatment, some of her symptoms still persisted. We sought out a nutritionist specialised in gut health in her area to do some further testing, and they discovered severe gut dysbiosis (which is definitely expected with SIBO and following treatment) and candida (yeast overgrowth). Both of which can cause bloating and worsen histamine reactions. She’s also spent several years exposed to mould, including black mould and so at present, she is working with the nutritionist on a specific mould protocol whilst also rebuilding her gut, and continuing with the physiotherapy, visceral manipulation and the practices we established during our time together. She’s also investigating the root cause of her SIBO, so she can do her best to prevent relapse. Sophie’s journey is complex and a long one, but she’s made huge improvement along the way and she feels empowered, hopeful and relieved that she’s finally getting to the root of her symptoms. I really hope you find this episode helpful if you are also experiencing the same challenges!

As many of you may know, I’ve been busy delivery my course, Live and Thrive with Endo, which has just finished! As part of the course, I created a bonus module all about supplements for endometriosis, pain, inflammation and hormones. In my book This EndoLife: It Starts with Breakfast I actually go into supplements that have been shown to target endometriosis, but in this module, I dive even deeper. For those of you who are in need of some extra support with your symptoms or who are curious about the evidence behind supplementing for endo, I wanted to share a part of this module, specifically, the supplements which has been shown to directly target endometriosis and reduce its symptoms, severity and growth rate. Also, I want to make it clear that I believe in using diet and lifestyle changes to manage endometriosis, and getting to the root cause(s) of our symptoms. I usually use supplements later in my coaching with clients, to allow them to experience changes in their symptoms from an anti-inflammatory diet, physio, gut healing, etc. but if a client is really struggling then we do bring supplements in sooner. My point is, these shouldn't be used in isolation, but rather in tandem with healthy habits that support you to live well with endo and resolve the root problem behind your inflammation, hormonal imbalances, fatigue, etc. I’ve also distinguished between studies on animals or in vitro in contrast to studies on humans, as of course, for those supplements which haven’t been tested on humans yet, we need more research and larger studies would be helpful for all of these supplements. Here’s the transcript from the module: Disclaimer So before we get started I just wanted to share a quick disclaimer as supplements can occasionally come with side effects and health risks.  So as outlined in the agreement you signed when you enrolled into the course, you should consult with your doctor before starting a new supplement regime, this is especially important if you are on medication as some supplements can change how the medication works. It may also be important to get tested first before taking some supplements, like with vitamin D and iron. I’ll mention this in the slide if this is necessary, though I do generally recommend getting your levels tested either way. This is even more important when you’re trying to conceive or are pregnant, as some supplements aren’t safe during conception and pregnancy.  As you’re aware, I am not a dietician or medical professional. These practitioners are licenced to give specific prescriptive doses to individuals whereas I am not. Instead, these are general yet therapeutic doses (which essentially means effective) for the specific issues I highlight them as useful for in this lesson, provided to you for educational purposes with the intention that you will then discuss these with your doctor or the practitioner you’re working with before beginning. These doses are either from the studies, from my training or from other practitioners and are generally safe to use - if there are any risks, I have highlighted them in the slides.  Finally, you’ve probably heard the phrase ‘you can’t out-supplement a bad diet or lifestyle’ and it’s especially true with a chronic condition. You’re not going to reap the full benefits of these supplements if your diet choices and lifestyle are standing in direct opposition to them. I do think supplements play a role with endometriosis, especially as gut health issues, deficiencies and high inflammatory markers and low antioxidant markers are factors we see in our population, but they need to be alongside healthy choices. So keep that in mind as we go through this lesson today. Okay, now that’s the boring bit over! Let’s get to supplements! Endo Specific So of course, I wanted to start with endometriosis specific supplements that have been shown to target endometriosis, while also have numerous other benefits. Curcumin Let’s start with my absolute favourite, curcumin. Now in terms of endometriosis, the research is unfortunately only in rats or in vitro (meaning outside of a human or animal such as in a test tube or a petri dish) but hopefully we’ll soon have some human studies. Curcumin has been shown to inhibit the spread of endometriosis and lesion formation by reducing cell proliferation (the process where cells divide to make new cells) and by reducing the adhesion molecules which allow endometriosis cells to stick to surfaces and form lesions.  It also been shown to reduce endometriosis by speeding up the death of endo cells, known as apoptosis. Apoptosis is the normal death of cells in their life cycle, which endometrial cells are more resistant to than normal, healthy cells. ·Research also found that curcumin slows down growth rate by reducing oestrogen levels inside the endometrial cells, so they essentially have less fuel to feed them. Of course, as you probably know, there are now countless studies on curcumin’s powerful anti-inflammatory and antioxidant effects. In fact, in research it’s been shown to reduce oxidation levels in mice with endometriosis, which we know are high in people with endometriosis and contribute to endometriosis growth. In studies not on endometriosis, curcumin has been shown to… Be as effective as ibuprofen for pain relief when taken daily for 4 weeks at 1,500mg. It was also shown to have less GI side effects that ibuprofen.  It has additionally been shown to boost mood and cognitive function in several studies. One study on healthy adults showed that just one hour after taking curcumin, attention and memory improved and with longer term use fatigue, mood, stress and mood significantly improved.  It can also help to repair leaky gut and lowers intestinal inflammation by reducing the immune system’s reaction to LPS, which is why I tend to use it as one of the first supplements to try as it can heal the gut, lower inflammation in the body/gut/pelvic cavity and directly target endo. All important factors in better managing endo. Finally, it’s been shown to support blood sugar, which as you know is important for keeping energy levels up, inflammation down and hormone levels balanced. In one study on people with prediabetes, it was 100% effective in preventing the development of type 2 diabetes. So the general therapeutic dose is 500mg to 1000mg a day, ideally divided in doses but don’t worry if all you can find is a single large dose. Curcumin is generally metabolised quickly and so dividing the doses means we can have it hanging around in our body for longer, doing good work! You may feel the benefits of curcumin in a month or so, especially if you’re taking it at higher doses. However, for others it can take longer and for the best benefit we need to give curcumin at least six months to a year as the processes of directly targeting endo and reducing the effects of inflammation can take time. Of course, if you have adverse reactions, stop immediately and consult with your practitioner.  Finally, curcumin can be difficult to adsorb so when choosing a product, go for one either with piperine (which is an extract from black pepper) or is paired with fat or is labelled as ‘bioavailable’. Really, fat or piperine are the best options and take with a fat containing meal to aid absorption further. If you have interstitial cystitis, black pepper is irritating to the bladder, so definitely avoid supplements that just add black pepper itself and experiment with how you feel on the extract, as that may be less irritating. In the handout I’ve linked to one of my favourite brands which do a bioavailable form without piperine. Also, if you do have IC, avoid turmeric supplements and rather go for curcumin, which is the active extract from turmeric, as turmeric can also be irritating to the bladder. Generally, you’re also going to get more bang for your buck with curcumin because it’s in a more concentrated form than just taking turmeric. Quercetin Okay so quercetin is another one of my absolute favourites!  Quercetin has been shown in studies on rats to inhibit endometriosis growth by lowering oestrogen levels, stunting development. In another rat study, quercetin significantly reduced the size of endometriosis lesions. Quercetin is anti-inflammatory and immune supportive, which is of course important with endo as we know inflammation is high and the immune system is compromised.  It’s also a great leaky gut healer and is one of the supplements I recommend trying first for leaky gut due to its other benefits listed in this slide.  It’s also a powerful antihistamine which can be used for reducing allergic reactions, histamine intolerance and asthma symptoms. Dose wise, I don’t have a specific dose for endometriosis but for histamine issues, the dose varies from 100mg to 500mg. Dr Jessica Drummond recommends 100mg in our training, whereas I know Dr Aviva Romm recommends 500mg in her article on allergies. My personal feeling is that to reap the benefits for both inflammation, endo and histamine (which we know is often a problem in people with endo), the higher dose is probably going to be better here. Like with all of these supplements, we’re really looking at about six months at a minimum, unless you react, in which case, stop immediately.  Finally, a gentle caution here, from the studies and reviews, quercetin is deemed as safe and I’ve not seen any warnings from practitioners, but it does lower both oestrogen and progesterone through lowering FSH and LH. I don’t think this is a problem because as I’ve mentioned, it’s not come with any warnings in my trainings or by practitioners who use it regularly in their practice, but if you have low progesterone I would maybe use with caution. If you can’t afford testing and you’re not sure, I would just observe your cycle and if you start getting low progesterone symptoms, ease up on your dose or remove completely if necessary. Ideally track your cycle with the FAM to ensure you’re ovulating. Again, I don’t think this is a huge issue or risk but keep it in mind when using just to be safe.   N-Acetyl Cysteine Okay, another great supplement is n-acetyl cysteine.   N-acetyl cysteine has been shown in human studies to reduce the growth rate of endometriomas. It’s also been shown to reduce the size of endometriomas and endometriosis lesions, in some to the point where the endometriomas disappeared entirely. In fact, in one study, half of the patients treated with NAC cancelled their laps due to a reduction or resolution in symptoms and/or a decrease or total disappearance in endometriosis lesions and endometriomas.  As I mentioned, these studies also showed significant reduction or total eradication of pain and symptoms.  An added bonus is that in these studies, there were more pregnancies in the groups treated with NAC than those without so it may support fertility.  Finally, it also supports liver function as it is the precursor to the antioxidant glutathione (which basically means NAC makes glutathione). Glutathione is essential for protecting the liver from inflammation and damage from the toxins and waste materials it processes, allowing it to function optimally and aiding oestrogen clearance.  Dose wise, the studies used 1800mg, split into three doses of 600mg for three months. However, in my training we tend to use lower levels of 500mg - 1000mg.  One word of caution is that Dr Allison Siebecker warns that NAC may possibly aggravate hydrogen sulphide SIBO symptoms because this amino acid contains sulphur, which can worsen symptoms for some people. If you know or suspect you have H2S, I will just see how you respond as this isn’t proven, it’s just something she cautions as sulphur containing foods often aggravate those with H2S. Omega 3 Fatty Acids Next up is fish oil or omega 3 fatty acids, and as we know these fats are essential and most of us aren’t getting enough, so there’s definitely a real benefit of adding these into our supplement regime whether we have endo or not! Fish oil was shown to reduce adhesion formation following surgery on mice with induced endometriosis and reduced the inflammatory healing process post-surgery which could contribute to further endo development due to the heightened inflammatory chemicals. This led to the mice who were fed with fish to have fewer lesions than those who were fed a standard diet without fish oil supplementation; therefore this could be a potential helpful supplement before and after surgery (though I would argue it’s an essential daily supplement).  In rabbits, 8 weeks of fish oil treatment led to a significant reduction in size of endometriosis lesions.  In humans, several studies have demonstrated a reduction in pain and inflammation with endometriosis and pelvic pain.  It’s also been shown to significantly reduce pain in those with primary and secondary dysmenorrhea (primary means period pain with no disease or condition behind it, whereas secondary is period pain due to a condition like endo) to the point where less pain medication was needed.  Additionally, it’s been shown to be a powerful anti-inflammatory pain reliever for issues like chronic back ache and neck pain.  One of the ways that omega 3 fatty acids do this is through lowering inflammatory prostaglandins and raising the levels of anti-inflammatory prostaglandins.  Additionally, because of the powerful anti-inflammatory processes of omega 3 fatty acids, they may play a role in healing leaky gut and lowering intestinal inflammation. Many gut health practitioners use fish oil for this purpose.   The dose is between 1000mg to 3000mg a day. I personally find I get more relief from the higher doses, but it can be tricky to get hold of those levels without exceeding the dose recommendations on the bottle. I have linked to a few higher dose supplements in the handout, but if you chose to exceed the dose recommendations on the label, obviously that’s your choice but you’ll need to consult with a practitioner to be on the safe side. However, omega 3 fatty acids are generally very safe at these doses.  At minimum it’s advised to continue these for six months, but arguably omega 3 fatty acids should be kept in our supplement regime generally. If you’re vegan, look for an algae-based supplement that contains both DHA and EPA, because we need both. I’ve linked to a few in the handout.  The only risk is that they can sometimes thin blood, so speak to your surgeon ahead of surgery to see whether you need to stop taking them a few days beforehand, for keyhole surgery it’s unlikely, but just check. Pine Bark Okay so now let’s move onto pine bark, also known as pycnogenol. In one study on humans, pine bark was shown to reduce endometriosis-associated pain. The study compared pine bark to hormonal therapy and what was interesting was that the results were much slower in the pine bark group, but the pain reduction was long-lasting, whereas the symptoms returned in the group treated with hormones once they came off the medication. The dose used in the study was 60mg daily, split into two doses of 30mg for 48 weeks. Combined Vitamin E and C Now let’s move on to a combination of Vitamins E and C. In one study, high doses of vitamin E and C were shown to significantly reduce pelvic pain in people with endo. 43% of participants had a reduction in daily pain, pain during menstruation was reduced in 37% and pain during sex was reduced in 24%. The same study also demonstrated a reduction in inflammatory markers (which means measurements of inflammation) in the pelvic cavity. Additionally, vitamin C raises progesterone levels and is commonly used by naturopathic and functional medicine practitioners to support those with low levels. Vitamins E and C are also antioxidants and anti-inflammatories so can lower oxidation levels and inflammatory processes which can lead to endo progression, which is why there was a reduction in inflammatory markers in the study. Finally, vitamin E has been shown to reduce pain, pain duration and blood loss in people with primary dysmenorrhea.  In the endometriosis study, the doses used were 1000mg of vitamin C and 1200 IU of vitamin E for 8 weeks.  Now I don’t think this is really a problem because I know plenty of industry leaders in the hormone/period space who use vitamin C for low progesterone, but it does also raise oestrogen too so if you have elevated oestrogen levels it may be better to consult with a practitioner. General daily doses of vitamin C using a supplement are at much lower doses, so just taking a standard vitamin C supplement would be fine, but if you wanted to increase the dose to something like 1000mg, I would just either carefully track your cycle and how you respond and ideally, consult with a practitioner. Again, vitamin C seems to be standardly used to elevate progesterone without any warnings regarding oestrogen rising too, but I wanted to let you know in case. Also, if you have interstitial cystitis, vitamin C supplements can irritate the bladder so you may find it better to use an oral spray which you swirl around you mouth for a few minutes before spitting out. The vitamin C absorbs through the cheek, so you’ll still get the benefits, just without the bladder burn! Melatonin Next up is melatonin, which I don’t presently use in my practice because it can actually affect the menstrual cycle by delaying or preventing ovulation. Also, in my training we’ve seen case studies of people not responding too well to it as it can come with side effects such as fatigue, dizziness and headaches. If I were to use it, I would do so in collaboration with a naturopathic or functional medicine doctor who could provide further guidance and supervision. However, it’s been shown to be beneficial for endometriosis so it’s worth discussing and many leading practitioners do recommend it. In a study on rats melatonin was found to significantly reduce the size of lesions.  In a human study, it was also found to lower daily pelvic pain by 39% and period pain by 38% in women with endometriosis. The study used 10mg every evening for 8 weeks. In his book, The Endometriosis Health and Diet programme, Dr Andrew Cook advises trying between 0.5mg and 10mg daily, each evening and it’s recommended to build up to the full dose.  If you plan to try melatonin I would recommend working with someone to find the right dose for you, that doesn’t interfere with your cycle. Resveratrol Finally, let’s look at resveratrol.  In studies in rats, resveratrol has been shown to reduce the size, severity and number of endometriosis lesions. In human studies, it was shown to enhance the benefits of oral contraceptives by further reducing pain and inflammation through inhibiting aromatase (that hormone which converts testosterone to oestrogen). This was a small study on 12 patient who didn’t find oral contraceptives helpful, but when combined with resveratrol, 82% experienced total alleviation of their pain within two months. It’s also a powerful anti-inflammatory, which has been shown to reduce inflammatory prostaglandins. And finally, it has been shown to inhibit the formation of new blood vessels in endometriosis lesions, inhibiting growth. The study used 30mg daily for two months, though you of course could continue this for longer. Now like many of the warnings in this lesson, I’ve not seen any health practitioners caution the use of resveratrol for endometriosis, but at certain doses it can have the opposite effect, so for example, it can become pro-inflammatory. To my knowledge, 30mg daily is both a safe and effective dose for endometriosis which practitioners like Dr Andrew Cook recommend (in his book The Endometriosis Health and Diet Program), but as with all of these supplements, consult your doctor before beginning. Listen and subscribe on your favourite player or listen directly/download MP3 here or just listen below! Let's get social! Come say hello on Instagram or sign up to my newsletter. This episode is sponsored by my free Endometriosis Diet Grocery List. This pdf list includes all the foods I buy on a monthly basis, categorised into easy sections. I share my personal endometriosis diet plan, free recipe resources, recommendations to help you get started with the endometriosis diet and nutrition tips. Download here. My cookbook This EndoLife, It Starts with Breakfast is out now! Get 28 anti-inflammatory, hormone friendly recipes for living and thriving with endometriosis. Order your copy here. If you feel like you need more support with managing endometriosis, you can join Your EndoLife Coaching Programme. A 1-to-1 three month health and life coaching programme to help you thrive with endometriosis. To find out more about the programme and to discuss whether it could be right for you, email me at hello@thisendolife.com or visit my website. This episode is sponsored by The Pod Farm. Learn all about how to start your own podcast with the complete course from The Pod Farm. Aimed at beginners, this course takes a simple and straightforward approach to planning, equipment buying, setting up, recording, editing and hosting your own podcast. With hours of audio and video materials, and downloadable guides and useful links, this multimedia approach aims to have something for every kind of learner. From now until April 15, newsletter subscribers get 20% off the course price. Visit www.thepodfarm.com to enroll or find out more This episode is sponsored by BeYou. Soothe period cramps the natural way with these 100% natural and discreet menthol and eucalyptus oil stick on patches and CBD range. Click here to find out more and to shop: https://beyouonline.co.uk Show Notes References: Curcumin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533742/ https://www.karger.com/Article/FullText/491886 https://www.sciencedirect.com/science/article/abs/pii/S0753332217346838?via%3Dihub https://www.sciencedirect.com/science/article/pii/S1756464615000092 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407015/ https://pubmed.ncbi.nlm.nih.gov/24672232/ https://pubmed.ncbi.nlm.nih.gov/25277322/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476912/ Quercetin https://pubmed.ncbi.nlm.nih.gov/19462895/ https://www.hindawi.com/journals/ecam/2014/781684/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/ https://pubmed.ncbi.nlm.nih.gov/19297429/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273625/ https://avivaromm.com/remedies-seasonal-allergies/ NAC https://www.hindawi.com/journals/ecam/2013/240702/ Omega 3 Fatty Acids https://pubmed.ncbi.nlm.nih.gov/16531187/ https://pubmed.ncbi.nlm.nih.gov/2832216/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614254/ https://pubmed.ncbi.nlm.nih.gov/11687013/ https://pubmed.ncbi.nlm.nih.gov/17434511/ https://pubmed.ncbi.nlm.nih.gov/22261128/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257651/ Pine Bark https://pubmed.ncbi.nlm.nih.gov/17879831/ Combined Vit C & E https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856484/ https://pubmed.ncbi.nlm.nih.gov/11762659/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484190/ http://www.usa-journals.com/wp-content/uploads/2013/07/Al-Katib_Vol18.pdf https://www.fertstert.org/article/S0015-0282(03)00657-5/pdf Melatonin https://pubmed.ncbi.nlm.nih.gov/23602498/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881748/ Resveratrol https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413140/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191968/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413140/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/ https://pubmed.ncbi.nlm.nih.gov/25462211/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/ https://pubmed.ncbi.nlm.nih.gov/23091400/

It’s another Syntax Highlight. In this episode, Scott and Wes take a look at portfolios and websites and evaluate them from the perspective of a hiring manager. Sanity - Sponsor Sanity.io is a real-time headless CMS with a fully customizable Content Studio built in React. Get a Sanity powered site up and running in minutes at sanity.io/create. Get an awesome supercharged free developer plan on sanity.io/syntax. Sentry - Sponsor If you want to know what’s happening with your errors, track them with Sentry. Sentry is open-source error tracking that helps developers monitor and fix crashes in real time. Cut your time on error resolution from five hours to five minutes. It works with any language and integrates with dozens of other services. Syntax listeners can get two months for free by visiting Sentry.io and using the coupon code “tastytreat”. Mux - Sponsor Mux Video is an API-first platform that makes it easy for any developer to build beautiful video. Powered by data and designed by video experts, your video will work perfectly on every device, every time. Mux Video handles storage, encoding, and delivery so you can focus on building your product. Live streaming is just as easy and Mux will scale with you as you grow, whether you’re serving a few dozen streams or a few million. Visit mux.com/syntax. Show Notes 04:50 - https://shaquilhansford.com/ Not optimized for desktop Lots of spacing issues overall Too many accordions - could be lists in multiple columns Social links could be in the footer Twitter is on point - iwantyoutohire.me Phone number on website is good 11:31 - https://www.benlammers.dev/ Gimmy dat yellow The design and polish is really good Data URI images can overload CPU Semantic headings, but HTML should use some work Four H1s on the page 20 H2s 40 H3s Main tag 20:28 - https://www.zubairaziz.com/ Lots of empty space Photo is key Not sure what to do when I land on the page Blog is nice, but two posts from May - add more or drop it Portfolio is just enough Nav animation should only happen on initial load 29:39 - https://codebyfil.dev/ This is a great example of something that is good, but needs a bit of polish Tone down the border radius Tone down the box shadow Border and drop shadow Images aren’t links Footer padding or space - contact is ridding the bottom Scott’s HTML breakdown Four H1s Six H2s Four H3s 18 H4s Five H5s 37:39 - https://www.johngeorgesample.com/ Clean but maybe too clean Nav is too distractingly too big Need active link indicator in main nav div div div div - take a look at those semantic HTML tags No H1 or H2 HTML needs work brother Use × instead of X Asterisk doesn’t work on mobile 46:52 - https://stordahl.dev/ Great images Nice typography Sign-up for newsletter is great Store = A+ Scott’s HTML breakdown Two H1s, one of which is just nice to meet you Zero H2s Articles should be articles No section 1px move on hover is nice - could use a transition Links Axe Accessibility Testing Gatsby Next.js https://feathericons.com/ Snipcart GeoGuessr ××× SIIIIICK ××× PIIIICKS ××× Scott: Walkabout Mini Golf Wes: 60w Portable Charger Shameless Plugs Scott: Node Fundamentals Authentication - Sign up for the year and save 25%! Wes: Advanced React - Use the coupon code ‘Syntax’ for $10 off! Tweet us your tasty treats! Scott’s Instagram LevelUpTutorials Instagram Wes’ Instagram Wes’ Twitter Wes’ Facebook Scott’s Twitter Make sure to include @SyntaxFM in your tweets

In this episode, I talked with Mohamed Sorour, a student from the EAEAT, the Egyptian Academy For Engineering And Advanced Technology which is affiliated to the Ministry of Military Production of Egypt. We chatted about Geopolitics, the importance of the Oil & Gas Industry in Egypt and the Middle East, the discovery of the Zohr Field and its relevance in the new Natural Gas trend as well as how is life as an engineer in such arab states. We also discussed two processes, the Amine Gas Treating, which is used to "sweeten" or remove impurities of H2S in natural gas as well as the TEG Dehydration used also in Natural Gas Treating. I really enjoyed this one, since it is now a student in a not so conventional private university but a university affiliated to the Military Ministry as well as covering some theoretical concepts and HYSYS Simulations. Show Notes: https://www.chemicalengineeringguy.com/the-blog/podcast/mohamed-sorour-a-chemical-engineer-from-the-eaeat-academy-affiliated-to-the-ministry-of-military-production-in-egypt/ --- Send in a voice message: https://anchor.fm/chemical-engineering-guys/message

Gel Cell and Lithium Ion and Christmas Song: 00:00 "Mrs. Santa Claus" by Jingle Punx, from the album "Coal" Intro: 01:35 Christmas time in North Texas. Feedback: 02:30 John, M0JFE, likes the show and asks for a show about packet radio. Thanks, too, to Bill at SolderSmoke for the mention. Damon, NN7B, listens to both shows, and asks how sealed lead acid batteries compare to nicad and nimh for a grab-n-go kit or mobile station? Donations: 07:54 Thanks to David, no callsign given, in Pleasonton, CA, andJerry, KD0BIK, of the Practical Amateur Radio Podcast. 08:48 Different music format this time - Christmas music. 10:40 Take a look at the Cafe Press store for Resonant Frequency merchandise. Click through the Amazon link at our site. Song: 12:42 "Goin' On a Date With Santa" by Dr. Elmo, from the album "Up Your Chimney" Buzzword: 16:16 Superheterodyne, presented by Tim Sutton, KI6BGE.http://en.wikipedia.org/wiki/Superheterodyne_receiver Song: 22:34 "Don't Want No Bones for Christmas (I Want An Electric Guitar)" by Paul Austin Kelly, from the album "Don't Want No Bones for Christmas", Topic: 25:54 Batteries: Gel cells and lithium ion. Gel cells are a type of valve-regulated, lead-acid (VRLA) batteries. They have a pressure-relief valve to allow venting of hydrogen during overcharging, and a gelled electrolyte. Theyhave a greater resistance to extreme temperatures, shock, and vibration than typical wet-cellbatteries like the common car battery.(Contrary to what Richard says, hydrogen is a colorless, odorless gas. The "rotten egg" smellfrom an over-charging car battery is due to the creation of hydrogen sulfide gas, H2S. -Ed.)http://en.wikipedia.org/wiki/Hydrogen_sulfide36:04 Lithium Ion batteries.Most of the newer electronics, like laptops, handheld radio, etc., has Lithium ion batteriesdue to their energy to weight ratio, and no memory effect. They also have a low self-dischargerate and are lighter than other types. Their service life depends on the time of manufacture,regardless of number of charge/discharge cycles. The internal resistance is higher than mostof the other chemistries. Song: 41:44 "Send Me a Wife for Christmas" by Dr. Elmo, from the album "Grandma Got Run Over By A Reindeer", Conclusion: 44:42 Listen to Linux in the Ham Shack, too!Happy Holidays! Closing song: 46:42 "Jingle Bells (Dan the Automator Remix)" by Dean Martin, from the album "Christmas Remixed -Holiday Classics Re-Grooved" Read More About Resonant Frequency: The Amateur Radio Podcast At www.rfpodcast.info Glossary - See Glossary for terms used on the show.

In this episode, we sit down with David Milburn from HypoAir to talk about air quality in our home environment. We dive into the dangers of mold toxicity, how to clean up your air at home, and take a look at some cutting-edge technologies that can assist with this!**DISCOUNT CODE**Use code B&B10 at checkout for 10% off your order: https://hypoair.com/beautyandthebiohackerABOUT HYPOAIR:https://hypoair.comOur proprietary technologies are backed by 15 years of laboratory, university, and "real world" commercial studies. These tests are available upon request, and cover topics including VOCs, MERS, Molds, MRSA, O3, TBC, HCHO, RSP, NH3, H2S, and many more.ABOUT DAVID MULBURN:David Milburn currently serves as VP for the Young Trust, a tech focused VC firm, and the CTO of Hypoallergenic Air LLC. At HypoAir, Milburn has spent 10 years solving some of the world's worst air quality issues for clients ranging from aerospace manufacturing facilities to hospitals in Brooklyn during the height of COVID. Over the last decade he's assisted thousands of business owners, homeowners, and biohackers of all walks of life to solve their unique air quality challenges.ABOUT BEAUTY & THE BIOHACKER:Learn more: beautyandthebiohacker.comEmail us at info@beautyandthebiohacker.comABOUT RACHEL & KATIE:Learn more with Rachel Varga BScN, RN, CANS, Board Certified Aesthetic Nurse Specialist https://RachelVarga.caBOOK YOUR ONE ON ONE Virtual Skin and Aging Consultation with Rachel Varga here: https://RachelVarga.ca/get-startedLearn more with Katie Type A: https://katietypea.comCheck out Katie Type A's YouTube Channel: https://bit.ly/3le3MUJDISCLAIMER: Information in this podcast and interview is not to be taken as medical advice, and always consult with your Physician before making any lifestyle changes. The material shared by guests in this podcast is not the opinion of Rachel Varga or Katie Moore, and disclaims any responsibility of inaccurate credentials of guests or information used that may cause harm. Always consult with your licensed Physician before any lifestyle modifications.

 JEFF STERNS CONNECTED THROUGH CARS Jeff and Jay jam about the car business, reminisce about arguing with Grant Cardone at a conference, Jay's serial entrepreneurship and well....cars!   00:11 This is how Jay smithwick arrives to the Jeff Sterns podcast.       Jeff Sterns  01:22And when you said to me, would you pay $500 a month for you to have all of your inventory on the internet so they can see it instantly. So if Jay can put all my cars on the website, I still have to FedEx some because not everyone has internet yet     Jeff Sterns  05:02 So I was one that I remember one time, I don't remember the struggle that you and I were having. I don't remember what it was, but I remember that it was the first time I ever thought of calling somebody's wife.     Jay  08:39 I was trying to get out of the car business because it was just beating me up and I still was having issues personally with myself. answered an ad went to a company that had the big brick cell phone wired cars RVs and that if you push the button, it called rural Metro … It was the OnStar before OnStar         Jay  11:22  you forgot surf bike. I don't even remember surf, though. There was an ad in a newspaper about a marketing representative. And because I've served, I gravitated to this 12 foot long PVC board with a bike seat and bike pedal. And I marketed it for I think I took the job of $500 a week and I drove around Florida and inevitably realized that to put a bike that rode in on the water you don't do it in Florida, why 10 months of outdoor activity, alligators and freshwater with lily pads to get tangled     Jeff Sterns  12:20We we bought the Rolls-Royce franchise… it was the strangest thing. It was a Buy Here Pay it was Bennett auto sales   Jay  14:34 now understand for the audience. For Carlisle Lincoln mercury in 1994 we attend a Grant Cardone motivational car knowledge  conference with 200 salespeople in the Tampa Bay area. Yeah, and I actually forgot that I actually go with Jeff Sterns, we're gonna go see Grant Cardone, you know, salesman, we're bored. He comes another rah rah blah, blah, blah. In the front row, we have to sit. …   Jeff Sterns  15:47only one topic that we argued about, obviously, I'm not the one with the private jets and the 10,000 square foot condo.           Jeff Sterns  17:11 And in the end, we ended up being number one in certified Pre Owned rolls and Bentley in the nation. We ended up being number one in Rolls Royce east of the Mississippi. So I'm sure people in California or Vegas or Arizona or someone beat us. We were number one are tied for number one customer satisfaction for a number of years with a Houston dealer. awesome guy there. And then when the Bentley Continental GT came out, we had the second largest waiting list on the car after Palm Springs, and people converting from a reservation to a real 20 grand deposit or really ordering the car. We had the highest conversion to really getting a car. So for an area that nobody drove these cars       Jay  18:29 Now let's fast forward. I start AutoExact data photo collection back then 98       Jay  18:55   I said, Jeff, you need to embrace this internet. He goes, No, no, we take photos. And he pulls out stacks of Polaroids. He goes, No, I don't need photos. We just send 2030 Polaroids in an envelope.   Jeff Sterns  19:16 Every time a car came in, right? I take it under the tree so there wasn't glare on the grass, take a few pictures, run it to the drugstore at the corner and get five developed. So when I get phone calls about them, we could FedEx and when you said to me, would you pay $500 a month       Jeff Sterns  19:39 I'm thinking well Geez, we're only a few years from having a website and barely anyone even knows.             Jeff Sterns  21:30 And you're shooting pictures for six or 700 stores now. Yeah.       Jay  22:01 dealer mouth.   Jeff Sterns  22:03Okay. Do we have to talk about the failed business?   Jay  22:07Hey, if you ain't throwing shit up against the wall, you ain't trying. That's right.           Jeff Sterns  23:08 So 11 years ago. 360 booth well, so this is an environment.           Or you would want to own? Even though it was you've never really owned the supercar right.       Jeff Sterns  27:15 But my favorite car at the time, was, Well, you know what? I didn't I didn't have it. So I mean, the car I really wanted at the time was a Ferrari F 40.     Jay  28:33 FF which looks like you know the golf or stationwagon Ferrari. Right? Because of the long wheelbase and the touring in. It's a 12 cylinder. But once again, that's a car that you would love to own. But I wouldn't feel comfortable driving the perception of the Ferrari and the half million dollar car even though it's not but it's not my DNA.       Jeff Sterns  32:00 Well, I mean, I'm sober also about 25 years. I I'd have to look it look up the exact date.   Jay  32:05 Right. Me too.   Jeff Sterns  32:06 I agree that so the reason that we use those of us attics is we're not really looking for a feeling we're usually avoiding. Correct some feeling. And then we later learned that the best way to the other side of the problem is not around, not under it, but just you got to go right through it. Right. And the beautiful thing about getting everything is you get everything. So I love what you just said that about feeling the bad stuff? Because it really does it really well. First of all, when I went sober, and then there you know, one of the steps of sobriety is you got to find make your list of people that  you own amends to.   Jay  32:48 I never got that call, by the way!!   Jeff Sterns  32:53 I've been waiting myself, okay. So you can always you always know friendships on the rocks when they're scorekeeping. So, when you make your list of a men's people, you own a men's two and you go make your men's.         Jeff Sterns  37:30 So you pulled up in a beautiful gt3. Correct. I do remember a Hummer H one.   37:37 Yes.   Jay  37:39 H2s came out. I was surfing pretty regularly at the time. And this is 2006 and I was driving from Tampa to Cocoa Beach and chasing tropical storms and hurricanes before they hit. And then after they left. And I convinced my wife that I needed a like surfing Safari vehicle. And I dreamt one up and I found that Reeves imports. Great people have had a h1, it had us and braid like Sedona, Arizona has landscape on it. But it was brown and had all the big. Everything you wanted in a convertible h1 it was a showcard had like 4000 miles it was more 2000 miles on it bought it for $37,000.   Jeff Sterns  38:25 What are those worth now?   Jay  38:26 over 100?   Jeff Sterns  42:33 well, and cars have a great way of doing that. I mean, you see you get behind the wheel of that car. You're 16 every time reminds you Yeah. And yeah, most of the cars I've chased have been cars that I grew up in that my dad had       Jay  44:30 we're done with the RS. all four wheels turn. So I mean, you want to do a U turn. You just break everybody's neck and just pull it is crazy. is crazy.   Jeff Sterns  44:41 Now the car I heard you talk most about absolutely was the Infinity q45.   Jay  44:47 I thought because that thing had 345 horsepower. Now we're going back to 1993 92 white leather or so it had leather but it was the sedan that had horsepower. It was like, attainable. You talked about it so much. I really did. I really I didn't see it. I never owned     Jay  45:08 the 900 tops Saab turbos in the late    .         Jeff Sterns  45:56 How about when you were selling cars? I mean, you've been in a lot of businesses since do you bring forward? I mean, was that any education for you? Now without doubt,   Jay  46:03 any salesperson needs to go sell cars first. Now back in the day, you didn't sell a car you didn't eat. I mean, there was a draw. But minimum wage, minimum wage, it was a couple 100 bucks. And I remember, and I probably could find it, I've literally got a two week check for like a buck and a half, right? Because   Jeff Sterns  46:21 they take the draw back. When you add more to that to your drug dealer.   Jay  46:26 You make like a $2,000, check and get $1 50 back because they have taken all the draw because you didn't sell anything because you were pretty occupied doing whatever the hell you're doing. Okay. But that truly made me who I was the desire was there. But now the car business gave me the hunger. So when you did work in the car business, you made money.   Jeff Sterns  46:45 You know, Jay, I always said that. Everybody, when they get out of school should go to Europe for one or two or three months see the military, right? And needs to sell cars for a year? Absolutely. I think you learn more about the human condition, telling people what their trading is worth, and having to nurse them through that thing. Correct.   Jay  47:06 You just got your head ripped off, you owe five grand more than it's worth. And now I get to bury that equity into your car and add to it just it's brutal.   Jeff Sterns  47:19 Right, but it's there's a lot of life skills in there. And it's funny the guys I've talked to already on these shows, or talked to about going on the show that are highly successful, interesting people. You know, we talked about Billy, I hear if they've sold cars I hear over and over again, everything that I ever I was able to pull everything forward for my car selling experience   Jay  47:40 in my industry in the same respect to though back when we were selling cars. 1% of the people lasted a year.   Jeff Sterns  47:47 Right? There's a little bit of turnover   Jay  47:49 was a lot of turnover, because you either had to sell or you starve. And then you had a lot that made me who I am. And every day even though I can probably pay my bills for a solid six months, I still get out and think I'm broke and it's time to go to work.   Jeff Sterns  48:06 Now you've never acted comfortable. No,   Jay  48:08 I know. If you're comfortable. You're in trouble. So where have you been?   Jeff Sterns  48:13 What countries   Jay  48:14 you've been everywhere to Desert Storm Turkey, Saudi Arabia, UAE, northern Iraq, Spain, Northern Africa. And then with 360 booths 3040 days and five trips to New Zealand greatest place ever put it on the bucket list. Australia is great, but it's very similar to Walt Disney World, Orlando. It's very condensed and beautiful in in a small area and then three miles out you're in pasture. In Australia, you're out in the outback. Very cool experience. Guam, Hawaii, Canada, Vancouver's beautiful Anchorage, Alaska. We have a studio that was amazing. you'd hold up your cell phone and you throw away the picture because you just couldn't get the scale. Right of Alaska. You just can't do it. God bless you when you shoot a photo that looks great in Alaska. So to date today, this year during COVID and since the January of last year, I've traveled 6.6 and a half times around the Earth in airline miles. I've got 900 cities, I'm from May I got 141 flights and love every minute of it.   Jeff Sterns  49:30 You are amazing, you know from an energy level from adapting. And what I mean from adapting is, I know that when you make a flight, you sometimes need to get up at two in the morning or 10 in the morning or time zones or going overseas to go or be okay   Jay  49:46 I leave San Jose adapting that was a great because I was like boy, I must have really done well. I would have jumped out of the plane. However late leaving Dallas closes the airport get to the tarmac. You're sitting there for an hour. 45 minutes, get out of the plane, go to the rental car agency, you're there another two hours, my plane was supposed to leave its land at 730. I left the airport and rental it 15 minutes after midnight. So with no hairy carry events, but you love it. I   Jeff Sterns  50:17 mean, you know, I mean, being on the road isn't as sexy. Now, it's cracked up to be for now for some people. But for you, it's amazing to me, and I don't want to put this wrong. Like, you don't necessarily need the next sale like, and I'm kind of the same. I come to work every day like my lights are gonna go out if I don't sell something, right. And I think you do the same thing. Absolutely. Yeah. And the way that you travel, but you put yourself into these situations that are uncomfortable and you adapt, adapt, adapt, and you're still socially posting for your business and personally, and it's upbeat messages and it's positive   Jay  50:53 and it's business now borderlines a little crazy. So I'll fly to New Zealand on a one way ticket. Okay, like, Who does that? My wife says where you stand, I'll find a place when I land. You can't book travel, and hope that that schedule goes, it's way too stressful. It's far less stressful, a little more costly to book as you travel through. So when I start my week, I'll make my appointments. And then I'll just book tickets an hour before the plane leaves. So you couldn't take an average person and ride shotgun with me because you would be into some type of panic shingles attack within about six hours.   Jeff Sterns  51:35 But is it more costly? Or is it cheaper to book an hour before?   Jay  51:40 And I would say 75% of the time, we have COVID extremely cheap, right? Because now they just need to fill a seat. Right? Like one of my guys are going to Vancouver Monday. It's $129. Right?   51:53 nuts.   Jay  51:53 The Vancouver from Tampa. It's not correct. It's one stop. But you know, I was just telling my wife, I got home, I was tired. And I said, Boy, if the traveling doesn't humble, humble you because right now they're in COVID, you go to California, the restaurants are angry. They literally made him take all the furniture out of the restaurant so you can sit down. Then you go to Florida, where you're wearing masks inside. But everything is open and we're going to town. I'll sit at a restaurant in Dallas and I don't want to wait for a seat. So I sit at the bar and I'm elbow to elbow with somebody else. And that experience of being able to do those things. Like I was in Dallas, it was 39 degrees of rain and took a picture of the dash on the highway. And then I took one here in Tampa Three hours later, and it's 84 and sunny. It's very humbling to do that. I call it time traveling, right? I'm not gonna have anybody beat me either, where the others are doing zoom calls and hoping for the best my asses in the seat making should happen. And it's not always a winner. There's not always a winner.   Jeff Sterns  53:00 So you travel the way you travel. You've been You've done enough airline miles to do three and a half times around the Earth already discounting. Excuse me six and a half this year. You and your wife ever want to take a vacation is that.   Jay  53:15 So early days? Well, we didn't do vacations for 10 years starting a business. And then I really love Laguna as you can tell, but we would rent a little house for 10 days prior to season. So like 10 days for three grand versus eight grand a week. In June, we'd go to Laguna and but now we have an elderly dog. We now have 360 booths. She'll do 14 hours a day, six, seven days a week. Just trying to keep up with the taxes the influx employees out of three auto exact AI team in 360 booths phenomenal I get to pick from auto exact for the guys. vacation. No we have no desire to go to Mexico or to the beaches. I think we're all in the Clearwater Tampa Bay area at the poor man's Bahamas. So why go to the Bahamas. I would like to take her to Laguna and go back to her house again. I would love to take her up to Lake Tahoe. I was there during COVID I mean go to like Tao. It's gorgeous. We haven't 19 year old dog death. It's her baby. Our baby but she so right now you can't fly. So it's been two years since she's flown.   Jeff Sterns  54:27 Now. How about your own bucket list? I mean, God forbid you mentioned this aneurism. Right and you're diagnosed with this aneurysm. There's nothing you can do nothing.   Jay  54:37 You hope it does and six months to a year. You hope it doesn't grow. You try to eat right stay away from sugars. You basically and I bet a bet. After diagnose I just start to play with your head sure that you're a ticking time bomb. So I went up to Cleveland Clinic, schedule appointment. Linux great. I felt like a VIP guests there. But it cost me dearly for going out of going out of   55:08 pocket of your engineers who I know. But   Jay  55:13 yes, you do not stay healthy and don't hold your breath and lift something heavy is basically what they say.   Jeff Sterns  55:19 But changing your diet impacts the possibility of this thing. No,   Jay  55:23 nothing's gonna grow. It'll only make it worse. So you can't like shrink it. Okay. Yeah, you know, it's there. Like, COVID I'm gonna live my life. I'm gonna wash my hands, put my mask on and do everything possible not to get sick. Not because of the aneurysm because I don't be sick, right? Um, so live your life and you go on. I can't live in a closet.   Jeff Sterns  55:46 But it seems like you're doing everything you want to do. Is it possible that you could have a bucket list? Is there anything you want to do? You haven't done?   Jay  55:53 You know, it's crazy. I never really I tried to see as much as I can. When I travel. My last time to Australia, I decided, well, I'm going to do something. So I hit Great White, and I actually found one of two places in the world, South Australia. Lincoln, Port Lincoln, you bought a boat at 6am. It's a little fishing village, surf village in South Australia. You bought a boat and you go out through a past where you get two hours of 10 foot waves. But when you get out to the grounds, there's seals clean for dear life and great whites, they drop a cage off the back of the boat. And on a ventilator you jump into like 47 degree water. And you see great whites. And that was not necessarily buckless I never even thought that was humanly possible. It was a National Geographics thing, right? And when you first see it, and you're in the cage, right, isn't there wasn't there for me it was like I'm seeing Bigfoot, because you only see that on TV. But boy, incredible. Wasn't a bucket list. I don't really have a bucket list. I really, you know, I saw my first wife die of melanoma cancer. So you can't live with regrets. So I tried to live now bucket lists or bucket lists for me it was not 100 foot yacht or private plane or things like that. But it's definitely to, you know, do what you can to have this experience called life.   Jeff Sterns  57:23 Well, Jay, I think we might be at an hour. Oh, we're waiting. And I know you're at your limit and an hour. The reason I wanted to have you first of all appreciate the friendship, I appreciate you. You're in town just a few days and you came out to the Jeff Sterns Studio solely took your time New Year, I   Jay  57:38 thought it was a Saturday, it's a Friday. So New Year's Day, by the way, right.   Jeff Sterns  57:43 And the reason I wanted to have you on here, the value I wanted to give to the listener, whether they're in the car business or not in the car business, is you weren't a particularly phenomenal student and you went into the military, trying to give yourself a little discipline, right? You've got your demons, like a lot of us do with   Jay  58:01 if you don't   Jeff Sterns  58:02 have one, you're kidding yourself that whatever. You're a lowly car salesman, lonely, you tried a few entrepreneurial,   58:11 had two things add to   Jeff Sterns  58:14 and you know, you've done you deserve all of your success with your 607 whatever. You have car dealers that you're taking upon the hour of the day. Yeah, do they come and go? I understand.   58:25 How many staff do you have?   Jay  58:27 I think there's just over 50 or 60. Right now. I actually Marcus runs it. So unless there's issues, I've watched everybody's emails, it runs pretty smooth. And Marcus, he's phenomenal.   Jeff Sterns  58:40 Now, Marcus, you're not here to defend yourself. So   58:41 I'll just say it,   Jeff Sterns  58:42 I showed you how to take a picture of a car under the tree without the glare on it. There's nothing you can do. I'll make that a promo clip. I'll just pull that out for 30 seconds, that'll be Marcus's clip, but I appreciate it. I hope that the listener or the viewer, got a little inspiration about what can be done by anybody. I mean, I think statistically, I mean, I don't take anything away from you. Right, but I think if you look back on yourself, statistically,

H2S: it's out there, we need to be aware of it and know how to plan around it. In this episode, Matt and Justin discuss what Hydrogen Sulfide (H2S) is, how it impacts drilling programs, and what mitigation plans can be put in place for when it is encountered.

H2S: it’s out there, we need to be aware of it and know how to plan around it. In this episode, Matt and Justin discuss what Hydrogen Sulfide (H2S) is, how […]

Kat McKinnon's agency, CopySmiths, produces hundreds of blog posts per month for, mainly, ecommerce clients. She's developed a formula of sorts for getting those posts ranked in Google's search results. "You need between 1,000 and 1,500 words for a blog article," she told me. "Definitely not 600. Avoid 800, unless you're literally just answering a short question. You need a heading that includes a keyword. You need three to four subheadings, H2s. And then within those H2s, you need three to four H3s. H3s are very important."

In this episode we talk with Dr.s  Wylde and Taylor, from Clariant Oil and Mining Services, about their article on page 37 in the May issue of World Oil. We learn how Non-MEA triazine-based scavengers decrease the occurrence of amorphous polymeric dithiazine solids, providing a best value-driven chemical solution to mitigate H2S issues in the field. Visit WorldOil.com for more useful technical articles and up to the minute news on the upstream sector of the oil & gas industry. Special thanks to Michael Gaines from NOV for the Intro and Outro. Be sure to listen to his podcast NOV Today. Send questions and feedback to deepdive@worldoil.com        

In dieser Folge sprechen Klaus und Daniel mit Sascha aus Berlin über Gerüche im Kanal. Wie sollten Betreiber bei Geruchsproblemen vorgehen? Wie sieht Sascha eigentlich aus? https://www.noz.de/video/38079/hitze-und-der-sinkende-wasserverbrauch-sorgen-fuer-gestank Wie tief sind Pumpwerke in der Regel?

Doc is taking the night off on this one and the Heart2Start Fantasy guys stepped up! In this episode Da Bros and H2S go over their week 3 rankings and debate the differences. Tune in to this episode then hop over to the Heart2Start Fantasy Football Podcast. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

This chat provides a a sip of something for everyone, from makers who want to improve their skills to consumers who enjoy knowing why a cider tastes a particular way. In this Cider Chat, we look at the next step after primary fermentation of cider and discuss the benefits of racking the cider over and why you may chose to not rack your cider. If you are a newbie to cidermaking, I recommend that you first listen to Part 1 of the Cidermaking Series How to Make Cider at Home Part 2-4 of the Cidermaking Series feature conversations with the Cider Team as Stormalong. These 3 chats are technical and help both DIY and commercial makers sort through cleaning techniques. Cidermaking Series Part 2 - Maker Tips for Growth and Cleanliness Part 3 - Cidery Sanitation Tips Part 4 - Scrub-A-Dub Valves and Vessels In this chat, I am going to lend my views and tips on Racking Cider. What does it mean to Rack Cider? Racking Cider is transferring cider from one vessel to another. Racking does not fully stop fermentation. I consider it a slowing down of the fermentation. Why should I rack the cider? Racking is done to help clarify the cider. When should I rack my cider? Racking is done after primary fermentation. Look for dead yeast cells and apple particles to fall to the bottom of the vessel. I usually wait approximately 1 month after primary fermentation to do my initial rack. This time varies and could be up to 2 months. What happens if I don’t rack my cider? The dead yeast cells which drop to the bottom of the vessel are called the lees. Lees left to sit for any extended period of time can give off flavors to your cider especially if you have to much head space. Headspace is the gap between the liquid and the stopper. If the headspace is larger than 2 inches the cider can oxidized and develop off flavors. When cider is oxidized it can taste like cardboard and that is not desirable at all. Leaving the lees in the cider and stirring them in is called Bâtonnage. Bâtonnage is stirring the yeast into solution. Benefits of Bâtonnage From episode 233 with Ryan Monkman - Ask Ryan | Quarantine Quad Series Part 3 Nano proteins are the biggest benefit of Bâtonnage They release into the cider providing a perception of sweetness and body with out the sugar Need at least 9 months to a year to get the nano proteins There are short term benefits. Yeast produces less carbon dioxide and bubbles. They slow down after the first primary ferment. Fermentation may have stopped but there is still sugar left. Lees absorb off aromas, except for H2S rotting egg smell. Bâtonnage helps to maintain a reductive state. Full reduction - rotting smell is a type of reduction. Which helps protect the cider from oxidization and protect the flavor components. Equipment needed to Rack Cider Second vessel of equal size - make sure it is food grade and sanitize before racking Food grade hose and racking cane extra stopper and airlock for 2nd vessel potassium metabisulfite Mentions in this Chat Listen to - Not all lees are Gross with Curt Sherrer Help Support Cider Chat Please donate today. Help keep the chat thriving! Find this episode and all episodes at the page for Cider Chat's podcasts. Listen also at iTunes, Google Play, Stitcher (for Android), iHeartRadio , Spotify and wherever you love to listen to podcasts. Follow on Cider Chat's blog, social media and podcast Twitter @ciderchat Instagram: @ciderchatciderville Cider Chat FaceBook Page Cider Chat YouTube  

SEO best practices are constantly changing as search engines fine tune the way they determine how to rank content. Here's what's working right now. This week on The Inbound Success Podcast, iPullRank founder Mike King shares the SEO strategies that he's using now to get results for his clients. From content and keyword strategies, to natural language generation, internal link generation and technical content optimization, Mike goes into detail with tips about how you can spot SEO issues that might be hurting your rankings, and what you can do to fix existing problems and proactively position your site to rank well. If you love getting into the technical weeds (like I do), this episode is for you! Resources from this episode: Visit the iPullRank website Check out Mike's movie Runtime Follow Mike on Twitter Read Mike's Medium article "This, too, shall pass" Transcript Kathleen (00:00): Welcome back to the inbound success podcast. I'm your host Kathleen Booth. And this week I am excited to welcome my guest Mike King, who is the managing director of iPullRank. Welcome Mike Mike (00:32): Kathleen. Thanks for having me. Kathleen (00:34): So excited for you to be here because I heard you speak back in, I think we decided it was 2016. I was attending Wistia Fest, which is not a thing anymore. It was an awesome annual conference that Wistia ran for a few years there. And I went to it and I, I saw you, you speak on the main stage about SEO. And I remember at the time thinking this guy is amazing. His talk is really good. It's packed with incredible substance, which you can't always say for main stage talks. And, and like, wow, I was just so impressed. And it was funny because recently when I was asking people in my network who I should interview for this podcast, your name came up and I kind of connected the dots. And I was like, that's that guy? So I'm so excited that like this has come full circle and now I get to meet you and, and pick your brain. Mike (01:40): Thanks for having me. And yeah, that was a great show. I really enjoyed Wista Fest. I really appreciate them as a company too. Like just their ethos. It kind of reminds me of early Moz. So yeah, I really love those guys. Kathleen (01:54): And they did a very Seinfeld-esque thing where they had a great conference that was growing and they were like, we're not going to do it anymore because we've realized it's not the right thing for us, but they definitely left while they were on top. So that was cool. So before we jump into all things SEO, can you maybe give my audience a little history on yourself and how you came to be doing what you're doing now? And also what iPullRank does. And I should note, as I say that, that this is basically the sixth anniversary of the company, so happy anniversary, that's a huge accomplishment. Mike (02:32): Yeah. Yeah. Thank you. I mean, it feels crazy to be here six years and, you know, just because of like the, the weight of everything that's happening in the world. So yeah, I'm very appreciative that we are still around. So yeah, me, my background, I did music for a living for a number of years, but, you know, before that, I grew up a very nerdy kid who learned to code from 12 and all this, and actually got into a bike accident. And and I didn't have health insurance cause you know, I was a rapper and this before Obamacare and I had to get a job to pay my medical bills. So first place to hire me was an SEO agency because of my, my technical skills. And then I ended up working at some bigger agencies and then some search focus firms. Mike (03:25): And then after that, I was just like, I'm pretty sure I can do this myself. And so six years ago I started the agency just put a, put like $5,000 in a bank account and never really looked back. And so what we do is, is digital marketing of course, with a primary focus on SEO and content strategy. And, you know, we work with a lot of clients and we really build that rapport and that trust. And then they allow us to do other things as well. So we've got some expertise in things like analytics and machine learning and so on. And there's just a lot of overlap between those that allows us to be very effective and the things that we do for our clients. Kathleen (04:03): I think it's interesting that you say, you know, your background, you were kind of nerdy and you learned to code because I feel like what marketing has evolved into these days, that is a super power, like people who know, who understand code and who, who are more data driven and, and kind of think like a programmer there's so much you can do with that knowledge, as opposed to the way marketing was taught way back when I studied marketing, which was like a much more about like strategy and creative. And it's just, it's a different discipline today. Mike (04:39): Yeah. And I think that we kind of exist at the confluence of like marketing technology, creative and like media, right? Like, so there's when I worked at some bigger ad agencies, everything was pretty rigid in kind of like what you just described. It's like, okay, you do that. We have a strategy, we do the creative, we run the media and that's it. But because with SEO specifically, you have to like fix the website, you end up like touching a lot of other different areas. And so that's why we ended up getting into machine learning and things like that because all of that supports what we're trying to do. And I kind of look at it as though, you know, the web is a program. You know, the search engine is a program. Your website is a program, that's an input for the search engines program. Mike (05:31): And so if you think of it as just like an ecosystem of program, you can make your website do anything and then you can make it ultimately, you know, work for these other programs. So if you think about something like personalization that is literally turning your marketing mix into a program that reacts to people's you know, their, their features and their behaviors. So yeah, I agree with you. It's definitely a superpower because if you think of, of everything in your marketing in that way, you understand that you just have so much control over what can be done. Kathleen (06:08): Yeah. It's amazing. And, and I know, you know, you have pretty deep SEO knowledge and experience. In fact, you were recently you were, you're going to be speaking at Moz con live, which of course, due to the crazy situation that we're in as a world, you presented at Moz con virtual you did something really different and creative that I want to maybe start with here. So can you talk a little bit about that? Cause it's so cool. Mike (06:38): Yeah. We made a movie. And the way I describe it as it's like Batman, the animated series meets the TV show, mr. Robot. And so they told me like the theme of Moz Con this year was going to be something like circus or carnival related. And I was like, all right, why don't we use a character that's like, kind of like the joker and make it like the three ring circus of technical SEO. And so you've got this protagonist who she's like this hacker type who is when you first meet her. She's just like doing all this SEO stuff, like super fast. So of course you got to present it in like a Hollywood way. Cause otherwise people would get bored. And then she runs into a problem. She meets me. I'm kinda like her coach. And so during the process of me coaching her to beat these different challenges, I'm also teaching the viewer different technical SEO tactics. Mike (07:32): So going into this, you know, like you said, I was excited to speak at Moz con live cause to me it's like the super bowl of SEO conferences. And when they said that they were going to go virtual at first, I was a bit disappointed because I really enjoy the, you know, speaking in front of 2000 people with my newest, coolest tactics and all of that. But then I realized like, no, this is an opportunity because not only is this virtual, but they want to do a prerecorded. And I'm like, alright, let's maximize this media, let's do a movie. And so my, the, the creative folks on my team were super excited about it. And we came up with a few different concepts of how we could do it. And then we just made it happen. You know, we, the, the music in the film is mostly in house. Mike (08:21): Like the person that is the voice actor for both the clown character and the woman, that's a protagonist also sings. The first song that you hear when the wind starts. Yes. Her name is Neferkara, she's our office manager. And she's so talented. And it was really cool to be able to like extract the talents of different people across the team. So like I wrote the script, I'm also a voice actor in it, our senior visual designer, she did the design concepts and then we've got designer who's also an animator who contributed. And then, because the timeline was so compressed, we also brought in a couple of freelancers to help us out. And it was just like, you know, one of those round the clock projects until we turned it in, like we literally turned it in. Like they said, we need it by 3:00 AM. At this point I had sent on the email at two 59 and 48 seconds. But yeah, we made it happen. It was a really fun project. Kathleen (09:23): So I just want to pause for a second. And for anybody who's listening, he made a movie. Like this wasn't just, let's film a video. This is like, you made a movie, you wrote a script, you brought in talent, it had a story. It was animated, which I think is, makes it even harder and more work. That just blew me away when I heard that. And when I saw it, I was blown away too, because it's really good. No, it's really good. And so where I, I'm sure the thing that everybody's thinking as I listened to this is wait, now I need to go online and see this movie. So where is this movie? Where does it live? Mike (10:05): Yeah. You can watch it on our website. You just go to i pull rank dot com slash runtime. Runtime is the name of the film. And it's right there and we watch it. Kathleen (10:16): So cool. So a lot of what that movie was about is what is working right now in SEO. And that's really what I wanted to talk to you about because, you know, SEO is one of those things that like, you can't learn it and be done, right. It's just constantly changing to the point where this week, you know, all I look online and, and I'm seeing like, Oh, there's a core algorithm update with Google. And then, and then two days later, it's no, they just made a mistake. And you know, there's all this craziness happening in the world of SEO, which is why it's so appropriate. So people who are listening to this can't see. But if you check out the show notes, you'll see it. Mike has this awesome zoom background, which is like, it looks like the house is on fire and the Simpsons is my best guess? Mike (11:01): It's from that meme with the dog where everything is on fire. And he's like, this is fine. Kathleen (11:05): Yeah. Everything's fine. It's fine. Literally the world is on fire. I feel like that's SEO half the time. Mike (11:12): Pretty much. Yeah. Kathleen (11:15): So, so yeah, I would love it. If you could just sort of like talk about with what you're seeing. I mean, most of the people listen to this podcast are pretty experienced and they understand content marketing and they get keyword optimization, but there's a whole nother level out there that I think unless you're a specialist, you, you just, you can't keep up with Mike (11:35): Yeah, that's the thing. So, I mean, SEO does change every day. There's algorithm updates regularly lately. And the thing is, people are very reactive to those algorithm updates. That's not the way you should approach it. Like if they roll out a new algorithm update, you got to wait a couple of weeks and see how that settles. Google is a software company, just like any other software company. And so when they roll things out, they may say, okay, we're going to roll out these five things at once. And they may say like, okay, four of those things didn't work. Let's pull those back. And only one of them stays there. So if you're jerking the wheel back and forth in reaction to them, you may end up being caught up in one of those things that wasn't actually a problem for your site. Mike (12:18): So I always tell my clients like, Hey, if you hear about an algorithm update, wait two weeks and then see where you fall from there. And the reality is that, you know, most of the things that you would want to do in reaction to one of those updates anyway, were things that we probably already told you you should do. Right? So it's not, it's not, it's very rare that it's a dramatic change to whatever you thought about doing or whatever your, no, you should have been doing it. And so it's all about prioritization from there, but to your point of it being another level, like most people that are doing content marketing don't necessarily know like how search engines think about content, right? So you may think like, okay, these are my target keywords. I got to talk about these keywords when I'm writing about a thing, that's the top level of it. Mike (13:12): So the way you got to think about it is that your keywords have keywords. And what I mean by that is that there's a context that's built based on what currently ranks for any given keyword. So as an example, if you rank for the, or you want to rank for the keyword basketball, and right now, the things that ranked for basketball also feature, you know, NBA bubble and LeBron James, and, you know, championship. Like if those words are featured on pages that rank, you also have to use those, those words on your page when you're trying to rank for basketball. And that's a simplified version of it. Like there are, you know, you gotta think about as far as like the topics being covered, the current, the people, places and things that are being covered. And we call this whole process of understanding that and using it technical content optimization, and it uses a lot of natural language processing to understand these concepts and so on. Mike (14:10): But the ultimate output from that is a very data-driven brief that we use to inform the content that we create. And these concepts are super powerful. You know, like again, most people are just being like, Hey, I want to rank for basketball. So I'm going to talk about basketball and use that word 49 times, but we will beat you because we're thinking about it the same way the search engine itself is, and we're looking at those topics and incorporating them so strategically, I would say that any content marketer that is, you know, optimizing for SEO, they should look into these concepts, more, plenty of tools out there for it. Search metrics, have a tool called content experience. SEMrush has a tool for optimization like this. There's a tool called phrase. So there's plenty of tools out there that do this level of analysis. Mike (15:02): And there's also a tool called content success by a company called Ryte. And what they do is like, as you're writing something, they'll say, here's my target keywords. It'll say, okay, well, use these words more, talk about these subjects more so you can be more optimized with respect to what search engines expect. So that's, that's one of the bigger ones that I would say that people that, you know, have knowledge about SEO don't know about this, and when they discover it, they see just like these small changes of how their writing would dramatically improve their rankings and so on. Kathleen (15:38): Yeah. It's interesting. Have you also heard, I keep hearing a lot of buzz about a newer tool called market muse. Have you heard about that? Mike (15:45): Yeah, they, yeah. Market Muse. They do a very similar thing. So they they've actually got a lot of different features and functionality to support this type of work. And they're also going into leveraging natural language generation pretty heavily as well. They do something that I can't remember the name of the product, but basically they'll give you a first draft of a piece of content based on what you're trying to target. And that type of technology has dramatically improved in the last couple of years, you know, or even the last few months. And that when people used to try to like generate content, they usually do, what's called content spinning. And that's where you kind of like take an existing article and just like change the words around like use synonyms and things like that. That's always been bad content. Now you have something called GPT two and also GPT three, which was put out by Elon Musk's company, open AI. And it's like really good at writing content. Like as long as you configure it, right. A human cannot tell the difference between a piece of content written by a human and written by this. Kathleen (16:59): It's funny that you say that because I just talked to somebody who rewrote 60% of his website using GPT three, cause he got access to the early beta and he was like, it's performing so much better. It did a better job of saying what we do than I could have done. And, and all these people in the Slack group I'm in, went to look at it and we were all like, that's amazing. It's crazy. It's like a little freaky though, because I don't know, like what does that mean for, for the future of us as marketers? Right. Mike (17:29): I think it means good things. You know, I think it frees us up to write content that's valuable and creative rather than like, imagine your eCommerce site. Right. And you're like, okay, to optimize these pages, I gotta write 200 words on every category page. No one wants to do, wants to do that. No one wants to write the copy that goes on product detail pages. They just want to be able to like take that data and turn it into something. Well, now you can't. And so it frees up actual copywriters and creative content marketers, and so on to think about how do we make interactive content? How do we write things that are like emotional and so on? Like, you know, I don't think we're going to get to a point in the near term that something like GPT three is going to be able to write conversion copy right now. I think he can give us some insights, but I don't think it's going to be able to very much be able to say like, okay, this certain type of person I want to write for them. Kathleen (18:30): Well, I think your key, you said the three key words, which was in the near term, I think eventually it'll figure it out, Mike (18:37): Right? Like we get to enough computing power and, and people are writing the right algorithms. Yes. You can retrain anything. But right now... Kathleen (18:45): Hopefully by that point you and I will be sitting on a beach somewhere and having a pina colada retired. Mike (18:54): But the other thing is that I think that we're going to get to a point where you can say, I want to rank for this keyword. And those types of tools would just ingest what ranks there and then use all those features that I'm talking about that we use as humans and it's going to write the perfectly optimized content for you. So then what is going to, what's gonna make, what's going to be differentiator between you and me and how we create the content. I think it's going to be those creative aspects that are going to be even more valuable. So GPT three does not replace your editorial team because you're still gonna need editors to edit whatever it spits out. And then you're going to need creative people that can create things that don't exist because GBT three learns from what does exist. Kathleen (19:41): Yeah. It's pretty crazy. But it also goes back to that point I was making earlier where, you know, programming and knowledge of code is a super power because you can't just like get access to GPT three and just like, it will know how to write your website. Like you had there's there's you have to understand how to leverage those tools. And there's a certain degree of technical sophistication required for that. At least at this stage, I'm sure at some point someone will build a software interface that will make it easy for anybody to do it, but that doesn't exist yet. Yeah. So that's pretty cool. So, all right. So we have number one, understanding the context around your SEO and that your keywords have keywords. I love that. What else do you got for us? Mike (20:23): Let's see. So I'm a strong believer that for, you know, the last like five or six years, SEO has become more content marketing. And a lot of people that do SEO don't know much about the technical side of it. And I don't think there's necessarily a problem with those people. I just think that the technical stuff needs to be brought back to the forefront because a lot of things have changed about the web in the last couple years. You know, JavaScript is more prominent in the way that search engines can understand that stuff and so on has changed. And so there's been a lot of new tactics that have popped up as a result of that. So one of which is AB testing specifically for SEO. So if you've got a big site and you're like, Hey, we're considering making this change before. Mike (21:20): It's like, well, we make the change and see what happens. Now you can do that as kind of like a step approach by taking a you know, representative sample of URLs, making that change there and validating or invalidating that hypothesis that this will work. And then once you see that it works, you can roll it out at scale. So I think that that's something that every SEO needs to know how to do, because that's a good way to avoid losing money. But you know, again, that goes back to the technical aspects because that is a very technical thing to do. Like you got to know more about CDNs and how sites are set up, or you got to know about Google tag manager and things like that. So my point here is that, you know, we're, we're still going through what I've, I've called for a number of years. Mike (22:07): Now, this technical SEO Renaissance where people that sit at the intersection of like code and, you know, creative marketing sophistication, and, you know, I guess SEO are able to really capitalize on things that others can. And I very much encourage, you know, SEO or content marketers to learn more about these things. So at least they can be aware and discuss with more technical people. Like how can we deploy this in such a way that what I'm doing as a content marketer works even better. So, you know, it used to be that you could just like build a site and put a bunch of great content on it. And the links that you would attract as a result of those, those that content would yield better rankings for you. But because Google has gotten more sophisticated and they have better understanding of the pages that are very rich in that type of content, you've got to understand things like server side rendering and dynamic rendering and, and Google's capabilities like where they end. So you can make sure that that content always has the best chance of ranking. Kathleen (23:22): How much do you think the average marketer needs to learn about technical SEO? Because like, I've always, you know, I've always kind of looked at the landscape of the marketing industry and there are some people who like all they do 24 seven, like their one job is they are a technical SEO expert and they do it really, really well. But I do think, I mean, it seems to me there is some baseline level of technical, technical SEO understanding that every marketer should have. I'm curious where you fall on that. Mike (23:53): Yeah. And I don't think that everyone needs to know how to do like 301 redirects and fix AC access files and so on and so forth. I think they just need to be exposed to those ideas. So if you're someone who read Moz's, you know, beginner's guide to SEO, I think that is a good base layer foundation of understanding technical SEO, because you're exposed to all those problems that you might have. And you can say like, Hey, I don't think the page that we just published is in our site map, that's important. Or I looked at, I looked at this plugin and it showed me that, you know, what is showing up for Google is not what I see in my browser. Like understanding those base level concepts is enough because you can find an awesome technical SEO, like you described, or even just an engineer themselves and be like, Hey, I'm at, I see these problems. I'm not the expert here, but can we look into this so that we can make sure that the content I'm creating is visible to Google? Kathleen (25:01): Yeah. That's kind of what I was going to say is it's like, you need to know enough to be able to recognize that you have a problem so that, you know, when to make that call, right. Like whether it's, I have a feeling, my images are too large. And so my page is loading too slowly or, you know, it might be, I need you know, more structured data on my website. I don't know how to do that, but I know what it is and that it needs to be done. Like there's sort of that level that I think is important for marketers to have. Mike (25:30): Yeah, absolutely. Cause you know, I mean, I personally come from a time back in my day where, you know, doing websites was you had one title and that was webmaster everything from master of all the web. Yeah. You were like a network administrator, you are front end and back end developer, you did Photoshop. Like you did everything. Right. So for me, like I want to know everything because I'm just used to that. But the modern web doesn't work that way. And so people have their, like their separation of concerns and that's fine. But I do believe that having like a general understanding of what someone like that technical SEO or engineer does just makes the end product even better. So I would recommend people just learn that foundational. Kathleen (26:23): Yeah. That's good advice. All right. So other things that you're seeing really kind of move the needle these days from an SEO standpoint. Mike (26:35): Yeah. so I mean, I'm, I'm starting to get super tactical. One of the things that we run with every single website that we pick up, especially because we work with mostly enterprise brands is they always have a bunch of external links pointing to pages that no longer exist. So the worst I've ever seen was, you know, one of the bigger sports organizations had 12 million links pointing to pages that 302 redirected. Now a Googler will tell you, there's no difference from how they handle 302s and 301s. I can definitively tell you that that is not true based on my experience. And this was a case where it was like one of the few things that we were able to push through in the organization was converting those 12 million, 302s and the 301s and their traffic shot up dramatically from organic search. So ever since then, I've, I've made sure that we always look for that. And every time you always find it, that's a problem. And one of the things that we do to make sure that that's not a problem moving forward is is with Ahrefs, which is one of the link index tools. They have a API end point for telling you what pages have broken links. So what you can do is set up a script. And again, this is something that you would work with your engineering team on. Kathleen (28:02): It all comes back to that coding. Mike (28:04): And I have a script that pings that API and says, all right, here's your list of broken links now automatically set up your 301 redirects from now. So then you don't have to worry about that as a problem. One issue though, is that Google and I believe this would be true. I don't have any definitive evidence of this, but it's something that I've like my hypothesis based on things that I've read in patents. They store copies of your site forever. So if you make a change to a page, they're able to look at what the previous version of that page is just like the way back machine. Yeah. And so if you implement a 301 redirect from one page to another, and those pages don't match up, like the content that used to be there, it doesn't match up with the content that is there. Mike (28:51): Now, they won't apply all the value of the link that you're redirecting. So the way that we've gotten around that, and again goes back to code. Google has something that they call the natural language processing API, which will allow you to determine the topics of pages. So what you would want to do is look for an old version of whatever page was there. Again, the way back machine is a good place for that and run it through that NLP API. And then they'll tell you all the topics and were called entities that were on that page. And then you run your other pages through that and find whatever page has the closest match topic. And then that's where you redirect it to. And then you're more likely to get more value out of that. Kathleen (29:39): That's cool. I did not know that. See, this is why I wanted to talk to you. I knew I was going to learn some new things. And by the way you were like, now we're getting tactical, I love this part of the conversation. So let's go into the tactical weeds. Do you guys have anything else like that? Mike (29:55): Absolutely. So another one that again, another commonplace thing that we see when we bring on clients, well, the first thing that we do is our SEO quick hits. So what are the things that are, you know, high value that we can do very quickly to show that, right? And another thing that we find, and this is especially important for big sites, but it's important for all types of sites. And there are links internally to pages that redirect. So 301 redirect is, you know, they're your last resort basically like when you have links pointing from an external site, it is difficult to reach out to a hundred or a thousand sites and say, Hey, can you update? So the 301 is the best thing you can do in that case, but within your own site, you have complete control. So you shouldn't be linking 301s because for every 301, there's a small loss of link equity. So again, whenever we get a site, we'll crawl a site and see what that internal linking structure looks like. And if there's a bunch of links to 301s, we fix those by just linking directly to the final destination URL. And then while I can see improvements from there, and the same is true of links to 404s. So those two things, and, and also with the external links, if you fix those three things, you will always see an improvement in organic search. Kathleen (31:17): That's awesome. And I feel like that's just like good website housekeeping. And it's funny you mentioned that because I was just doing that. We migrated the site at the company I work for, we migrated it from WordPress to HubSpot. And when we did that, it meant that everything basically was on one domain instead of sub domains. And, and it was like, it was a painful few days, but so necessary. I, I spent like three days going through old blogs, like fixing what were section headings and turning them into H2s changing the link so that they went to, they were like internal links and not external links that went to 301s, like the whole process was such a slog, but when it was done, I it's the same feeling I have like when I clean out the junk drawer in my kitchen. I'm like, Oh, I feel so good. Now it's all clean and perfect. Mike (32:06): Yeah. It's tedious, but it's work done. Kathleen (32:08): Yeah, it is. It is awesome. Well, I mean, I literally feel like I could sit here all day and talk to you about SEO and you're this endless fountain of, of incredibly useful knowledge, but we only have so much time. So shifting gears for a minute, I always ask people at the end of my interviews, two questions, the first of which is the podcast is all about inbound marketing and people who are doing it really well. Is there a particular company or individual that you can point to that you think is really setting the standard, what it means to be a great inbound marketer these days? Mike (32:43): Hmm. I mean, I feel like it's a cop out to mention Rand, but Rand is really good at it. Kathleen (32:49): You know what, you know what, I just want to say this came up once before. He's almost never mentioned, which blows my mind because he is the person that I would probably mention. So talk, discuss Rand. Mike (33:03): Rand is, he's like a inbound marketing machine, you know, like if you think back to the things that he was doing with Moz, where it was like he was blogging every night and he created the Fridays, Whiteboard Fridays, which he does, or he was doing every Friday. He had the beginner's guide to SEO, which he did the first iteration of, and then Brittany Mueller has taken over. So yeah, I think if, if you want to point to someone who is doing it and isn't a huge brand, like he's obviously, you know, a big influence in the space, you can watch him do it again right now with his new startup, which is Spark Toro. And so you see him blogging pretty regularly. He's putting out videos on like how to use the product. He is identifying new social channels that work for him. Mike (33:54): Cause you know, Twitter engagement is down pretty dramatically. Linkedin engagement is up and I'm starting to see him pop up there more. He's doing a ton of different, you know, podcasts and webinars and things. So I think Rand is a really good example of how to do it right. And how to really laser focus in on your audience and then like continually know what they need and put it in front of them. So then show like, Hey, I've also got this product. That's very valuable. And then the other thing is that, you know, he's always had like a very empathetic approach to everything that he's done. And what was really striking to me was that they have an email through Spark Toro that goes out right before they're going to charge you like a week or so. And it's like, Hey, you know, this is of course a subscription product, but we don't want to just like lock you into a subscription and make you forget like, Hey, your, your bill is coming up. If you want to cancel. That's okay. You're welcome to come back. So it's like proactively being like, Hey, we're going to bill you just like, no. And I really think that speaks to his approach and why it's a better approach than a lot of other things that you see out there. It's really good in that market. Kathleen (35:13): I could not agree more. And I, a couple things I would add to that. One is that, so it's Rand Fishkin, who was the founder of Moz, who now, as you've mentioned, founded this new company Spark Toro, which has an incredible product. That's a whole nother conversation, but the couple of things I've noticed about him, one, what he did that was so brilliant in Spark Toro is he started producing content before he had a product. Like I was following him before he ever launched that product. And he was building that audience. So that by the time the product was ready, you have this like ready-made group of people who were, who were waiting to just say yes to him, which is so smart. The other thing is that the content he creates is phenomenal. It's very, very high quality. So, you know, some people might hear, Oh, he blogs every day or however often he blogs and think, eh, you know, sure you could do that, but it's checking the box. Kathleen (36:04): He does not check the box. It's very, very good content. And he does a lot of research. Like that's why people follow him so much. And then the other thing that I just love about him, and I think this, you reminded me of this when you talked about the email about billing, is he's so transparent even about the negatives, like what people might perceive to be negatives. So he has this book he wrote called Lost and Founder, which is very transparent accounting of how he wound up leaving Moz and all the lessons he learned. All the mistakes that he says he made and what he would do differently. And it's just like, if you've ever owned a business, which you do, and I have, reading that book, it's so relatable and so refreshing to hear an entrepreneur talk about the things they didn't do right. Cause sometimes you feel like people only talk about their successes and that is so not a true picture of entrepreneurship. Mike (36:55): Yeah. I got an advanced copy of the book you know, at a, at a very challenging point in running my business and it was, and you know, I was like walking out the door to go on vacation. Like I can't see it anymore. And I took a copy of the book and it was so refreshing to read it and feel like, okay, there's someone else out there that understands this? Could you, you've got books. Like The Hard Thing About Hard Things by then, but that book is kind of BS. Cause it's like, Oh, everything got hard. And then I went and raised $60 million. Kathleen (37:27): Thank you for saying that. Cause I thought the same thing I'm like, yeah. Huh. Mike (37:31): Like that's not how this works in real life. So yeah, that book is definitely refreshing in that regard. Kathleen (37:37): Yeah. I totally agree with you. Well, and to add to that, you yourself have just published what I think is an absolutely beautiful article on medium about your experience as an entrepreneur and all the lessons that you had learned. It's like you basically wrote a letter to yourself sort of from the future about the things that you should be doing differently. And I just thought it was so spot on to, I mean, I just, I just know I related to it as somebody who has owned a business and specifically an agency and like been in those shoes. So I will put the link to that in the show notes because it's definitely something everybody should read. It's really great. All right, second question that I hear all the time from marketers is how do you keep up? Because marketing and specifically SEO, as we talked about changes so quickly, how do you personally make sure that you stay educated and kind of on the cutting edge of everything that's happening? Mike (38:31): Yes. Two things. One, following people that are not our industry. So I follow a lot of developers and things. And I just read voraciously, you know, I read all types of stuff and it's, it's very important to me to like have ideas that are not about my day to day. So then I can figure out ways to assimilate them to my day to day. And also it just like keeps me more broadly creative than if I'm just focused in on one thing. So yeah, it's just that, that curiosity and that thirst for knowledge and the way that I action that is my following more people and just keeping stuff coming at me. Kathleen (39:11): Awesome. I love it. Any one or two people you want to mention who you think are worth following? Mike (39:18): I'm putting you on the spot. Yeah, I can't really think of anybody. I would just say, you know, look at me on Twitter and look at who I follow. Kathleen (39:26): That's a good idea. There you go. Mike (39:27): The people, the people that you know are that will pop up first will be the people I've followed most recently. So yeah. Check those out. Kathleen (39:35): That's a good tip. All right. Well, Mike, I'm sure there are people listening who are like, I want to ask this guy a question. I definitely want to see his movie. I want to learn more about this company. What's the best way for them to connect with you online? Mike (39:49): Yeah. Just go to i pull rank dot com or just reach out to me on Twitter, which is just @ipullrank. Kathleen (39:54): Awesome. All right. Again, all of those links will be in the show notes. So head there to check those out. And in the meantime, if you enjoyed this episode, I would love it if you would head to Apple podcasts or the platform of your choice and leave the podcast, preferably a five star review. So that, that would help us get found by other listeners. And of course, if you know somebody else who's doing kick ass inbound marketing work, tweet me at @workmommywork because I would love to make them my next guest. That is it for this week. Thank you so much, Mike. This was a ton of fun. Mike (40:28): Thanks for having me.

It’s finally here! The long awaited episode on how to test for SIBO. Many of you have been contacting me to ask how to get tested or whether you can test at home, so here’s my episode discussing all the ins and outs. Here’s a breakdown of some of the key points in the episode: Hydrogen and methane type SIBO can be detected through a SIBO breath test. You can order at-home kits. In my experience, most GPs won’t/can’t order SIBO breath tests and aren’t familiar with it, though GI doctors may be able to and SIBO specialist doctors certainly can. A SIBO breath test involves drinking a solution of glucose or lactulose and breathing into a test tube for 2-3 hours. The substrate will feed the bacteria, which will create fermentation, and the gas is then collected in the test tube and measured in the lab in parts per million. Tests can be either 2 hours with 8 test tubes or 3 hours with 10 test tubes. 2 hours runs the risk of missing SIBO in a person with slow gut motility, so for that reason, I prefer to go with a 3 hour test. Some specialists prefer testing with glucose, others lactulose. I like to use lactulose as glucose is absorbed in the first 1-3 feet of the small intestine and the small intestine is on average 22 ft long! So if the SIBO is further down, a glucose test can miss it entirely. A prep diet and overnight fast is required before taking the test. This is a low to no carb diet of meat, fish, eggs, black tea or coffee. There are some allowances for vegans, vegetarians or diabetics. If a patient ate too many carbs, or did the prep test incorrectly it would skew the test results and the test would need to be redone. The North American breath testing consensus states that a positive for hydrogen would be a rise of 20 ppm or more (parts per million) from the baseline (the breath before drinking the solution) in the first 90 minutes. A positive for methane would be 10ppm or more in the whole 180 minutes, including the baseline. Dr Allison Siebecker, who I trained with, has a slightly different diagnostic range after years and years of working with SIBO clients and consulting with other SIBO specialists. A positive hydrogen for her would be 20ppm in the first 120 minutes, with no rise needed as long as the baseline isn’t the highest number. Methane is 10 within 180 but if constipation was present, the methane would be positive if the reading was 3-9ppm. Though hydrogen sulfide SIBO cannot be detected with this test, some H2S patients have a flat line pattern that indicates the presence of H2S. This would be a result of 6ppm or less for hydrogen and 3ppm or less for methane. An elevated baseline (so not 0) is normal for methane. In the USA, lactulose requires a prescription so you would need to find a doctor who could help you order it. For a deeper dive and my breakdown on how to take the test itself, have a listen to the show! I really hope this episode helps those of you who are suspecting that SIBO may be the culprit behind your endobelly. Let's get social! Come say hello on Instagram, Twitter and Facebook or sign up to my newsletter. If you feel like you need more support with managing endometriosis, you can join Your EndoLife Coaching Programme. A 1-to-1 three month health and life coaching programme to help you thrive with endometriosis. To find out more about the programme and to discuss whether it could be right for you, email me at hello@thisendolife.com or visit my website. I am now offering one-off two hour sessions for those of you who aren’t quite ready for a 12 week coaching programme. This intensive deep dive session will kick start your journey to living and thriving with endometriosis and give you a plan that you can take forward and work on alone. Click here to find out more about the programme. My cookbook This EndoLife, It Starts with Breakfast is out now! Get 28 anti-inflammatory, hormone friendly recipes for living and thriving with endometriosis. Order your copy here. This episode is also sponsored by my free Endometriosis Diet Grocery List. This pdf list includes all the foods I buy on a monthly basis, categorised into easy sections. I share my personal endometriosis diet plan, free recipe resources, recommendations to help you get started with the endometriosis diet and nutrition tips. Download here. This episode is sponsored by The Pod Farm. Learn all about how to start your own podcast with the complete course from The Pod Farm. Aimed at beginners, this course takes a simple and straightforward approach to planning, equipment buying, setting up, recording, editing and hosting your own podcast. With hours of audio and video materials, and downloadable guides and useful links, this multimedia approach aims to have something for every kind of learner. From now until April 15, newsletter subscribers get 20% off the course price. Visit www.thepodfarm.com to enroll or find out more This episode is sponsored by BeYou. Soothe period cramps the natural way with these 100% natural and discreet menthol and eucalyptus oil stick on patches and CBD range. Click here to find out more and to shop: https://beyouonline.co.uk Show Notes Smart SIBO Test Find a doctor Find a testing lab in your area Dr Siebecker’s testing info

ArcelorMittal South Africa on Wednesday said it will pay a fine of 3.64 million rand ($219,658) relating to charges of exceeding hydrogen sulfide minimum emissions standards at its coke plant in 2016. Chief executive of ArcelorMittal South Africa, Kobus Verster said they acknowledge that emissions at their Vanderbijlpark plant exceeded permissible H2S levels for a period of time in the past and steps were taken to address the problem but unfortunately the initiatives implemented did not adequately resolve the problems.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Don't forget to check out the video on our website here: http://tvpipesolutions.com/reline-live/#GcYKKXbeh14During this Reline LIVE we will be adding a new topic and exploring a sanitary sewer case study as well as a culvert rehab case study.Large diameter pipes and culverts represent the backbone of any city’s utility network for the collection and disposal of sewage and effective drainage of stormwater. In many cases the fabric of these pipelines, which may consist of brick, stone, concrete or clayware will have been constructed decades ago and although proven resilient, has eventually succumbed to the ravages of time, suffering the effects of H2S attack or erosion and may even be exhibiting signs of imminent failure due to structural loading beyond that of its remaining capability.At this point, the need arises to consider the means by which the structural rehabilitation of these pipelines and ducts can be achieved whereby a new, 100-year plus life expectancy can be provided with a high degree of confidence. Channeline international has been providing bespoke Structural Glass Reinforced Plastic (GRP / FRP) lining sy­stems since the early 1980’s, they have en­gineering and manufa­cturing experience for both Circular and Non-circular buried infrastructure worl­dwide.

Discover two cidermaking techniques that are also used in winemaking, called Maderisation and Bâtonnage. We delve into both of these topics in Part 3 of the Quarantine Quad Series called "Ask Ryan" with Ryan Monkman of FieldBird Cider, Ontario Canada answering questions from Cider Chat listeners. Maderisation: What is this technique and can it be used with cider? Bâtonnage: are there any short term benefits from bâtonnage or does one need to "stir up the barrel" for a long period (1 year at the least) to benefit from this technique? Listen Part 1 and Part 2 of the Quarantine Quad Series. Maderisation - The barrels are cooked - sometimes for years. Developing flavors called "maderised". If done well it can be delicious. High alcohol cider is best for maderisation - slower  bacterial growth. Cider that is has a low alcohol by volume  - likely to get organism spikes. FieldBird is planning to do a maderized cider from the 2020 harvest Northern Spy, fermented half way and fortified with apple brandy and let the barrel sit in a hot place. 17 Brix on the Spys (9%) ferment down half way and then add brandy. Getting 8% sugar. Sugar helps - creates the caramel flavor and provides an appearance of freshness. No MLF in the presence of sugar. Leave in cellar over the winter. Then leave the barrel outside all summer. 30 Celsius - 86 Farenheit. This will cause the maderisation The risk of maderisation is cooking a barrel to much The final product will be around 17-18%  Battonage: Is it worth it if you don’t have a full year to do Bâtonnage on a barrel? Nano proteins are the biggest benefit of Bâtonnage They release into the cider providing a perception of sweetness and body with out the sugar Need at least 9 months to a year to get the nano proteins There are short term benefits. Yeast produces less carbon dioxide and bubbles. They slow down after the first primary ferment. Fermentation may have stopped but there is still sugar left. Lees absorb off aromas, except for H2S rotting egg smell. Bâtonnage helps to maintain a reductive state. Full reduction - rotting smell is a type of reduction. Which helps protect the cider from oxidization and protect the flavor components. In wine, a Sauvignon Blanc, has rich tropical flavors which come from a rich reductive state, At FieldBird, they save lees in the freezer. Cracking - the freeze helps the lees cells break down. Using frozen lees that have cracked - means it will takes only 4-5 months versus 8-9 months in the barrel to get the benefits from Bâtonnage Contact for Ryan Monkman at FieldBird Cider website: https://www.fieldbird.ca/ Instagram  FieldBird https://www.instagram.com/fieldbird.cider/ Ryan Monkman https://www.instagram.com/rgmonkman/ Mentions in this chat Stories in Ciderville - send in fiction and nonfiction essays to read out loud on Cider Chat to ria@ciderchat.com September 1-6, 20202 England Cider Tour  Help Support Cider Chat Please donate today. Help keep the chat thriving! Find this episode and all episodes at the page for Cider Chat's podcasts. Listen also at iTunes, Google Play, Stitcher (for Android), iHeartRadio , Spotify and wherever you love to listen to podcasts. Follow on Cider Chat's blog, social media and podcast Twitter @ciderchat Instagram: @ciderchatciderville Cider Chat FaceBook Page Cider Chat YouTube

Understanding the Dangers of Hydrogen Sulfide Gas. Hydrogen sulfide (H2S) gas is produced as a result of the microbial breakdown of organic materials in the absence of oxygen. It can be found in tanks, vaults, voids, and other confined spaces at industrial facilities including power plants. Besides being flammable and corrosive, H2S is also colorless and toxic, even in relatively low concentrations, so it is extremely hazardous to workers. In fact, it is the second-most-common cause of workplace inhalation fatalities behind carbon monoxide. H2S is noticeable initially by its rotten egg smell, but the gas can deaden senses making it difficult for workers to detect without a gas monitor. Veriforce CEO Colby Lane and Chris Detillier, senior safety analyst with Veriforce, were guests on The POWER Podcast. Veriforce is a leading provider of software and services that enhance workforce and community safety. Among its offerings is a training course called H2S Clear, which provides students with life-saving information while meeting the compliance requirements of ANSI/ASSP standards. “It's extremely toxic. As little as 700 parts per million can cause someone to immediately collapse, and they can die from it,” Detillier said. “So, it is very important to have a good training program in place.” Lane explained that Veriforce's training model essentially credentials and accredits instructors. Then, those instructors provide the training to actual workers. Detillier said he's received a lot of positive feedback every time he's taught a “train-the-trainer” class for H2S Clear. “We've had guys that have been in the industry for years—some of them who have previously been through H2S training—and after class would tell me how much that they learned from the class and appreciate the content that we have in there.”

The power of old-school HTML formatting Alexa Flash Briefing Skill (SEO Tips) Hello, thanks for listening to SEO tips today. Today's tip is about old-school HTML formatting. Today's tip is focused on the power of using H1s and H2s, table andlt;tableandgt; and the rest. Search engines read [...]

Barb is a self-made woman who wasn't afraid to cold call, transform herself, and build herself a career many people aspire for. We discussed: • Barb is a 3rd generation oil and gas professional who grew up in Bakersfield, CA • She's lived through multiple downturns throughout her career • She's worked in the environmental space and worked on projects such as filtering poisonous gases from wells in the 1980's • Note: She references 128,000 - that's the concentration of H2S in the gas stream. Units are parts per million (ppm) , so 128,000 = 12.8%. For reference, breathing in 100 parts per million can kill you. • Challenges of working with field staff • We discuss social responsibility within the industry and the importance of acknowledging fear present in our communities resulting from energy production • She plays hard - and she works sometimes! • Course recommended: Compassionate Communication (also called Non-Violent Communication) Barbara Ganong's LinkedIn profile can be found here: https://www.linkedin.com/in/barbara-ganong-3a0552150/ Jake Adamson's LinkedIn profile can be found here: https://www.linkedin.com/in/jacob-adamson-ei-git-a3bba4103/ Jake's email: jadamson@ruleengineering.com Ellen Scott's LinkedIn profile can be found here: https://www.linkedin.com/in/ellen-scott/ Ellen's email: elscott6@gmail.com Mark Hinaman's LinkedIn profile can be found here: https://www.linkedin.com/in/markhinaman/ Mark's email: mark.hinaman@ypenergy.org

How did David Bain turn his podcast content into a book? This week on The Inbound Success Podcast, Marketing Now author David Bain talks about how he went from podcasting to livestreaming to publishing a book - and how any marketer can repurpose audio content into electronic and printed books. Highlights from my conversation with David include: David started podcasting all the way back in 2006. His first attempt at repurposing audio content was to publish transcripts and compile them together. When he did that, he realized that transcripts don't work well for creating longer form content that people want to read. If you're thinking of creating audio content, quality audio is key. David recommends purchasing an ATR 2100 mic. You can also add professionally recorded intros and outros. David uses an iPad app called Boss Jock to edit his audio. After David got more serious about his audio content, he began pre-recording video using hangouts. From there, he moved on to live streaming. In 2015, he recorded a year end episode for his podcast that featured 20 to 30 marketers giving tips. The next year, he decided to feature 100 marketers and make a book out of their advice. David has worked with both Kindle Direct Publishing and Ingram Spark to produce ebooks and physical books out of his repurposed content. Resources from this episode: Visit the Marketing Now book microsite  Connect with David on LinkedIn Follow David on Twitter Listen to the podcast to learn how to repurpose podcast content into a book - and what that can do for your marketing results. Transcript Kathleen Booth (Host): Welcome back to the Inbound Success Podcast. I'm Kathleen Booth, and I'm your host. This week, my guest is David Bain, who is an author with the book, "Marketing Now", coming out any day now, and also a prolific podcaster. Welcome, David. David Bain (Guest): Hey, Kathleen. Great to be on with you. Thanks for asking me. David and Kathleen recording this episode. Kathleen: Yeah, I'm excited to talk with you, because you have quite a bit of experience with podcasting. You're also a marketer by trade, who has held various marketing roles. But, it seems like recently your focus has really been on the medium of podcasting, and now turning what you've done with podcasting into a book. Maybe we could start out and just you could tell your story, your background, what you've been doing, kind of led to you where you are now, and what you're doing now? About David Bain David: Sure. I've come to realize recently that's impossible to do everything in the world of marketing. It used to be possible, I reckon, maybe about five to 10 years ago when you're talking about marketing or maybe digital marketing, to say that you're a marketer or you're a digital marketer, and people would understand that you do a broad variety of different things, but all under the marketing umbrella. Nowadays, it's just so much involved, I think you have to specialize a bit. I guess I'm specializing a bit in podcasting and live streaming, and turning that into a book, as you say. I've been involved, I guess, in marketing for about 15 years or so. It was about 2004 that I really started to realize that I could publish webpages and do things like Google Ad Sense onto the pages, and start to make some decent money out of doing that. That's how I got started in marketing experience. Within a year or so, people were asking me, "How on earth do you actually do that?" So, I was helping a few people to do that, and I ended up building that into a few digital marketing courses, and discovering podcasting about the same time. I actually launched my first podcast way back in 2006. Kathleen: Wow, that's really early days for podcasting. David: It is, it is. It's a year or so after iTunes introduced podcasts. Prior to that, I guess you could do it with RSS feeds, but it was becoming really technical, and there wasn't much of an audience out there. It was really iTunes that brought it into the mainstream. Kathleen: That's amazing. I mean, that's so early on. How did you decide to do a podcast at that point? David: I think I had an iPod, or maybe a device that could listen to it, or at least I was able to download iTunes onto a computer and then discovered podcasts through there, I think, and then thought, "Wow, this could be an incredible medium for marketing, or for actually broadcasting content and distributing content." I had a website at the time, that was a fairly generic business article's website, because at the time when you're involved with SEO, then if you wanted a webpage to be ranked fairly highly, then all you had to do was submit an article to a third party article's directory, and have yourself an author bio at the bottom that had a keyword-rich link back to your website. That could fairly quickly rank it highly. I thought, "Okay, I'll get into this article's game by having an article's website." So, I had a business article's website. The first podcast was actually reading articles in audio form that people had submitted to me. Kathleen: So, you were like Audible before Audible. That is so interesting. David: Well, maybe a very, very small version of that. Kathleen: Yeah, wow. Fascinating. It's changed so much over the years too, really. It's gotten so much more sophisticated in terms of the delivery mechanisms, and the people that are participating, and the formats, et cetera. David: It's absolutely crazy. Back then, you're only talking about 30 years go. We're obviously recording this in 2019, but it's night and day in terms of quality and technology that's available to you, but also people's Internet connections, and devices. There's just so many things that have happened over the last few years or so. From podcasting to publishing a book Kathleen: Yeah, it's amazing. Now, your latest kind of adventure is taking some of what you've done with podcasting and turning it into a book, correct? David: Yes, it is indeed. I think podcasting lends itself quite nicely to either producing transcripts, or making the content available to people in other means. What I tried to do initially was produce some transcripts of the show and publish that. I came to realize fairly quickly, that actually people don't love to read transcripts, books, articles, whenever people write anything. It's an entirely different form compared with the way they actually say something. What I ended up doing was transcribing a series of live streams initially, and then taking the transcripts and completely rewriting them, to be honest with you, to make them into a readable form for our book. It's a whole lot of work to do that. I figured out that actually, I had to have an eight hour live stream to produce roughly 60,000 words of transcripts, and that is an average size of a 250 page book resource, or an average book basically. But in order to actually get the book in really nice readable form, you have to rewrite it. So, it's as much work, if not more work, than actually writing a book from scratch. Kathleen: You know, this is actually a really interesting topic to me, because I have show notes, and my show notes include an executive summary, if you will, but then I include the full transcript. Part of the reason I do that is also just for accessibility, anybody who is hearing impaired and wants to be able to read it. There's also an SEO benefit to having all of that copy and keyword-rich stuff on the page, but I will say that it's interesting when you look at a transcript. I really read mine, and I go through and I don't really heavily edit it, but I just sort of clean it up a little bit, and I add some headings to make it a little bit more digestible. I'll add some links in here and there. One thing I've learned from doing that, is you're absolutely right when you say that people speak differently than they write, and also than they want to read. I have learned that I start pretty much every sentence with "Yeah." David: I know, it's horrible, isn't it? Kathleen: From reading my own transcripts. David: When you edit everything. Kathleen: It's horrifying. I have now this conscious effort I need to make to not say the word, "Yeah" at the beginning of a sentence, and I'll probably do it 20 times on this podcast now that I've said it. I've had a few guests who have, for reasons connected with how they manage their personal brands, who've wanted to go back and edit the transcript and make it sound like it was something that was written as opposed to said. It totally turns it into something different. I've actually had some debates. With one of my guests in particular, I had a real debate about this because I was like, "It's a transcript. It's there for people who can't listen to the podcast, and want an accurate representation of it. So, we can't just completely change it." But I like what you're talking about, because that's really taking it to a different medium, where you don't have to preserve the integrity of the transcript. You can turn it into something that captures the spirit of it, but is much more elegantly written, if you will. David: Definitely. There were so many things you were sharing there, Kathleen, that we could probably have a full conversation about. When you were talking initially about the fact that obviously transcripts themselves have to be turned entirely into something completely different. What I find is actually the guests, as you've to a certain degree alluded to, actually prefer the written form when that form is representing them. I've reached out to every single person that have participated in the production of a live stream, and they've been completely happy. So, I've done it with the approval of other people as well. But you're also talking about SEO, and an SEO benefit as well. I believe that although Google, because it's probably the most important search engine for the majority of us listening, although it is looking for text to crawl, it's increasingly becoming better at being able to look into audio and see what people are saying, and looking through videos and seeing what the video is about as well. It's not perfect yet, but we're getting to a stage where Google is going to be able to transcribe audio without the written text being there. To a certain degree, the SEO value of producing a transcript, I think next to a podcast, is going to diminish over time. Then the question is, why are you doing that? Are you doing it really for people to view? I've probably been a little bit lazy in the past, of not wanting to do podcast transcripts beside every single episode. Have you actually had many people ask you specifically for transcripts? Or are you doing it because you feel it's great as an inclusive thing to do for all of your audience? Kathleen: It's really more of the latter. Philosophically, I like the idea of making the content accessible regardless of someone's ability to consume it in a certain format. I've philosophically chosen to include transcripts for that reason, but I will say that it's interesting, I publish my show notes on IMPACT's website, which has a lot of traffic. There are several podcasts on that website, and I believe, if I'm not mistaken, that my show notes get more views than most of the other podcast show notes. So, I do have a theory that from an SEO standpoint, there's something there. But again, it's not just a straight transcript. Like I said, I put some H2s in to chunk out the sections, help kind of make it easier to digest. There's also a section at the beginning that if you don't want to read through a whole transcript. You can just look at that. It's been an evolving experiment, honestly. David: I think that's a lovely tip, actually, putting H2s in there, because Google is looking for ways to break down the tanks on a webpage. If you're demonstrating that actually it's more than a transcript to a certain degree, that is what you're greeting because you're editing it so much, and you're ensuring that it's correct, and you're making it as easy as possible for the reader to consume it. I guess those simple things like H2s and perhaps some other small elements that you can bring in like list elements, maybe, if someone's referring to a list as well, would make it much more likely for search engines to treat that text positively. Kathleen: Yeah, it's a labor of love. Quite honestly, I'm not sure if you just made an ROI calculation, if I could prove that there was the ROI and the amount of time I spend. But it's interesting. It's just sort of the direction I've been going lately. Getting started with audio content Kathleen: I feel like we could have a whole conversation about that. But back to yours. Let's actually rewind for a minute. Can you talk a little bit about the podcasting or the live streaming that you were doing, that led to this notion to create a book? David: Sure. Sorry, I can't help asking questions. It's the podcast career in me. Kathleen: No, it's great. I love it. David: I love having a conversation. Kathleen: This is a good conversation. David: I believe that when I see other people live streaming, or producing lots of video content that they get some of the basics wrong, such as decent quality audio. I'm a strong believer that people should start off with a basic quality audio podcast to begin with, and that if they do that, if they have a piece of equipment like... Sorry, I'm talking a microphone that I'm using at the moment actually, but this ATR 2100, I wanted to refer to. The microphone that I'm using is an Electro Voice RE20, which is a more professional microphone. The microphone that I was wanting to refer to was the ATR 2100. The ATR 2100 is a very basic dynamic microphone that you connect to a computer using a USB. It's got a more professional connection cord, an XLR as well, but you don't need to worry about that. If you have a basic microphone like that connected to your computer, you connect with someone using Skype, and you record using a free piece of software that you can connect to Skype. That's all you need to begin with. Then you record 20 or so episodes to begin with, and you get comfortable with producing your audio podcast, and then you move on to video after that. I would encourage anyone that is looking to do live streaming, produce video, is to really think about your audio quality to begin with because certainly when it comes to YouTube, many people consume YouTube videos by walking around the house and occasionally referring to the screen. They're actually out for the decent audio quality content, and they're more likely to skip your video if you're difficult to hear, or you're just not good enough quality. Kathleen: Yeah, I think that's so true. I mean, I have a Blue Yeti microphone, which is, I would say, kind of comparable to the ATR, around the same price range, and easy to connect. You don't need to be any kind of an expert to use it, and don't have to spend a lot of money. It makes a huge difference. To that, I would add, having a really good Internet connection because I definitely had a good solid few months when I moved offices, where my Internet was not reliable. It was some of the most painful times. I had people messaging me who were listeners going, "Have you checked your Internet? It's cutting out a lot." It makes for a terrible experience. You're absolutely right. David: I love your guest booking experience as well, because you are very definitive with guests, with regards to what's good and what's not so good as well. I've done the same thing with many shows as well. Unless you're very specific with people, then people are going to get it wrong, or their audio quality isn't going to be as good as it could actually be, and you're not going to be delivering the highest quality of audio product to your consumers. Some people are switch off because of it, so you have to be like that. Kathleen: Yeah, no one wants you in their ear for 45 minutes with terrible static, or as one of my guests once did, shuffling papers right next to the microphone. David: Yes, or beards, yes. Kathleen: It's just a horrible sound. David: I don't know if you've experienced many beards on microphones. They are not so good either. Kathleen: Yeah, yeah it makes a big difference. So, what type of podcasting were you doing that led to the live streaming? From podcasting to live streaming David: Sure. I got more serious about podcasting about 2014. I think I played with a little bit before then, but as I alluded to, I did about 20 or so shows to begin with solely in audio format. I moved onto what I considered the next stage to getting a decent microphone, doing things like incorporating my intros, my outros, and different bumper noises. I've got this app on my iPad called Boss Jock that I connect to a mixer, and then I can bring that audio into it as well. That makes the show easier to edit in that you don't have to do everything towards the end as well. After that, I started recording on pre-recorded video. I started Hangouts at the time as unlisted video. Then that made me feel more comfortable, because I knew that if everything went wrong I didn't have to release the video at all. It made me feel less stressed to begin with, when I was getting involved with video. The next stage after that, as I see it, is live streaming and actually live streaming to social media, and looking at comments as you're live streaming as well, and being able to bring those comments into the conversation. There's so many different skills involved, and different aspect of that when you're starting video to begin with. You want to be comfortable looking into the camera, at least for the intro and the outro sections of your show. You want to be incorporating your musical elements, if you bring that into the show as well, and of course the readers' comments as well. You just can't do that to begin with. I see so many people, as I mentioned earlier, just starting live streaming and not being able to do that because they haven't gone through those steps. Kathleen: You were doing some podcasting, if I'm correct, for SEMrush as well as for MobileMonkey. You've had a lot of experience, both with your own podcasts, working with some other companies. David: Yeah. Repurposing podcast content into a book Kathleen: What gave you the idea to think about venturing into the world of books? David: Of books. Well, I've done, as you say, a lot of different podcasts. I've probably interviewed about 500 different marketers, so I've got an incredible database of contacts out there, people that I can reach out to. About 2015 or so, I decided to produce an end-of-year show, so perhaps I'd interviewed about 100 people by then. I thought, "Okay, it's be a lovely pre-Christmas-type show to get 20 or 30 marketers on and all give their thoughts of the year, what's their number one tip from what's happened during the year." Yeah, I had about 20 or 30 people on. It was about a two hour live stream, and it went really nicely. The following year, I decided to double it up and potentially make a book out of it. The following year, I did a four hour live stream and had just over a hundred marketers join me live. I gave them all three minutes each to share their number one actionable tip. I took the content and made my first book out of it. It did fairly well. It sold a few thousand copies. It just seemed to be the next logical step in terms of publishing content. I think you have to go where the opportunity is, but you have to really look to see what your competitors are doing out there, and also you have to work harder than other people who are out there. 10 years ago, I used to be able to publish blog posts and quite easily get those blog posts ranked. Then it moved on, and you had to publish incredible blog posts that 2000-5000 words long. Now, unless you've got a fairly authoritative domain name, it's even quite hard to get those sorts of posts ranked. "So, where are the other publishing opportunities?" I thought. Well, perhaps it's not even online at all. Loads of people still read books. It doesn't have to be Kindle book. It doesn't have to be any book in any form. It could be a physical copy book, and people still read physical books: paperback books, hard copy books. "First of all," I thought, "Well, it's very hard to publish a book. It's a lot more effort to publish a book. So, if I publish a book then it's going to position me above other people producing content around the same kind of topic." Then I thought, "Well, there are thousands and thousands of people that want to read this copy in book form as well." So, I guess those are some of the reasons I chose to publish a book. Kathleen: I have to laugh, because hazards of podcasting, I'm in my quiet home office and my dogs start to go crazy. That's the home alarm system, as I like to call it. David: Oh, that's great. I heard that in the background, Kathleen. I was wondering if you were able to edit it out at all. I thought, "Okay-" Kathleen: No, I always tell my guests when I listen to podcasts, I like it to be really organic and not overly scripted. So I say, "You know what, we're going to roll with it." So, I'm leaving this segment in so everybody can hear my two Labrador Retrievers who like to play- literally, if anybody walks by the front of my house they go crazy. David: And I was trying to talk over it, thinking- Kathleen: You're so good. David: Maybe you were going to be able to edit that out, and it was going to be easier for you to- Kathleen: No, we'll leave it in, because- David: Okay. Kathleen: It just gives more color to what's really happening behind the scenes. David: Great stuff. How David published his book Kathleen: You decided to publish a book. Can you talk a little bit about how you went about doing that, because I've had a couple of people on who've talked about writing and publishing books, and they've all taken different approaches. This is something I'm very interested in. I've spoken to so many marketers who've talked about either wanting to write a book, or wanting to use the content creators within their company to create a book as part of their marketing strategy. David: Yeah. Kathleen: There's the route of working with a publisher. There's self-publishing. There's so many options now. Can you talk about how you specifically did that? David: Sure. I haven't gone down the working with a publisher route, mainly because I think there's more profit in it being a self-publisher. I initially, several years ago, published some books just for Kindle. If you publish books for Kindle, then as long as you're charging between $2.99 and $9.99 in US dollars, then you can get 70% commission as a result of doing that. So, that's quite appealing. Then after that, when I published my first physical book, which was called "Digital Marketing" in 2017, that book was also published using a service called CreateSpace at the time. That's been merged into KDP, which is called Kindle Direct Publishing, but you can publish paperback books through that service. If I'm publishing a book for $14.99, and through that service for a book that is 268 pages long, it's costing me about $4.10 per book to get that book produced- Kathleen: Hard copy. David: No, that's our paperback copy. That's a paperback. Kathleen: Oh, okay. Well, yeah, but I mean printed. Printed copy. David: Yeah, absolutely. Yeah, sorry. I'm just differentiating because hard copies- Kathleen: Hard cover and paperback, right, right, right. David: Exactly. They cost quite differently. But paperback, they cost in general just over $4.00 if you're producing a book which is about the same size as mine, which is 268 pages of paper. Kathleen: Am I correct that, because I've talked to somebody else who has used Kindle Direct Publishing, am I correct that there is no minimum quantity for orders? You can order like one at a time? David: Yes. Yeah, yeah exactly. You can order them yourself personally. You can get your pre-published copies, which have a bit of a nasty extra bit on the front to say, "Do not resell." Then after it's published, then you can get the proper versions, which are the single copies. However, obviously you're going to be charged postage for doing that. So, sometimes you're better off getting 10 copies, or something like that. You can also do the same through another service called IngramSpark. IngramSpark also will produce that hard cover version of your book for you. If you're producing a hard cover version, then it's normally about five or six dollars to produce, because you've got that hard cover on top of it, and you've got your sleeve on top of it as well. So, you generally have to price it a bit higher. Hard cover versions, they're generally about $25.00. The paperback version is generally about $15.00. There's not much more profit in the hard cover version. I think the only benefits really for the hard cover version, is the perceived value of it. Because again, it looks like a higher quality product, so if you have your own events, and you're speaking at events, and you want to take hard cover copies of your book with you and sign them, then the hard covers are very nice in terms of perceived authority. Kathleen: Yeah, it's really fascinating to me, because the technology is such now that anyone can really do this. There's no issue with affordability. There's no issue with you need to have the connections in the publisher world. Anyone can write a book and publish it, and create a really very professional quality-looking printed version, as well as Kindle version, which presents an amazing opportunity from a marketing standpoint that so few people have taken advantage of. David: Well, it's hard, hard work to do and it takes a lot of time to do. So, I can understand where people don't want to do it. But I think it's about planning your content marketing out for the entire year, and if you're doing a podcast, if you're doing a series of blog posts, if you really think about it then you can design 12 chapters in a book out of the content that you produce. To a certain degree, you can write your book over your year out of your content that you're already producing. So, it needn't take a whole lot more effort. Which came first, the podcast or the book? Kathleen: Is that the way that you went about doing it this time? Did you really conceive of this in advance, and then create audio content kind of knowing that your end game was to create the book? Or did you have this audio content and then think, "Wait, this would be great fodder for a book." David: It's the way that I probably will do it in the future at some point. What I did this time was a few months ago, I hosted a massive live stream which was eight hours long. I had 134 marketers on that. Then I took the transcript of that and then completely rewrote it. Then I determined the categories of each piece of advice that all the marketers share. So, it was just the one question that I asked everyone. Hello doggy. I've got a two old son, and he likes to say, "Hello doggy." Anyway, look I think what I did this time was a whole lot of work, probably too much work, but it was a learning process as well. I categorized all the content after receiving it, because I was just about to say I asked all the marketers the same question, "What's your number one actionable marketing tip right now?" They all shared that number one tip. I thought the tips that were shared fitted very neatly into three key sections of the book, and then also into 12 categories from there as well. The 12 categories, of course, turned into 12 chapters. From the research, I've done 12 chapters. It's quite as nice number to have within a book. That's a nice way to break it down, if you're planning a book as well. If you want to write a whole book as a one-off, 60,000 words, that sounds quite a lot. But if you break it down into 5000 words per chapter, even 4000 words per chapter, plus an introduction and conclusion, then that's not too much to do. The difference between blogging and writing a book Kathleen: Now a lot of the marketers that listen to this podcast are prolific content creators. They are very accustomed to blogging, to writing articles. Many of them are also podcasters of their own right. I'm interested to know from your perspective, what do they need to know about creating content that is intended for a book as opposed to writing articles or blogs, which is a little bit more episodic, is there something different that you need to do as you approach that project? David: I think the key thing is, is to have that thread. So, to have that thread that binds the different chapters together. So, you can't just write 12 separate large pieces of content without that intended thread together, and the intended overarching topic of your book. I think you have to start with the end in mind. A good way to do that, is actually to research Amazon, to have a look at categories of books and to see what exists already, and where the opportunities are. Because one outcome that some authors wish to achieve is to get a bestseller. You can get bestsellers in different categories of Amazon as well. It's quite nice to take a screenshot of your book being number one in a category of Amazon. If you look into what topic of marketing, or another area of your business, and you find a category that's either under-serviced or perhaps doesn't actually have the type of book that you believe that you can offer, then that's a good place to start. Then you've got your topic of your book. Then it's a case of brainstorming maybe three sections, then four different chapters within those sections of your book, and then starting writing from there. Then you've got your thread, which binds everything together. Marketing your book Kathleen: So you write the copy, you probably create cover artwork, you pull all this into the Kindle Direct Publishing system so that you're able to publish the book through it. You just talked about people wanting to have Amazon bestsellers. What does someone need to know as far as the work that has to happen to market the book, especially before it's even published, because the little amount of research I've done into this, it's very clear to me that a lot needs to be done before the book even hits the virtual shelves, to lay the groundwork for a successful book launch. I'd love to hear from your standpoint what you're doing for that. David: From a successful marketing perspective on Amazon, one of the key things is reviews. It makes it more likely for people who stumble upon your book to decide to make that purchase if there are positive reviews. So I think that's a bit of a given. It's much, much better to have something in the region of 10 reviews in the marketplace that you want to target. I'm targeting with USA and the UK, and you want to have a reasonable number of views in those marketplaces. You've also got to be thinking about [crosstalk 00:31:22] together. You've got your hard cover, your paperback, and also your Kindle edition, and perhaps even an audiobook version as well. They can be all tied together. You can ask Amazon to tie those things together. One of the important things to try and get on a bestseller list within Amazon is to get a decent number of sales within a short time period. I would be guessing to a certain degree, but I'm pretty sure that if you can get maybe even just 100 sales of your book within 24 hours in a category of Amazon that's not particularly competitive, then you're quite likely to get fairly high within that category. So, a number of reviews. If you publish your book a few days before you intend to say that you're going to publish it, you reach out to your friends and your colleagues, and you ask them to buy it, and then you ask them to submit a review as well. Then on publishing day, you do some kind of live event. I'm doing a massive live stream on launch day. One of the intentions behind that is to get as many people as possible to buy it as soon as possible, and to get that algorithm of Amazon to notice that there's a lot of sales of that particular product happening. That's going to move it up the rankings. Kathleen: So I did see that. I went to your MarketingNowBook.com website, which if you're listening, you should check it out. I saw that you have the book launch party set for December 10th. I'm definitely going to sign up to listen to that. I'm curious to see how that comes off. It's a great idea. It's interesting what you said about having a slightly different date when the book goes up onto Amazon versus the official launch date. David: Yeah, well you can do that with one person. With IngramSpark, it's possible. There are lots of strange technicalities. With IngramSpark, it's possible to have your book available to purchase prior to launch date. With Amazon paperback, with a KDP paperback, it's not possible to do that. But with Kindle, it is possible to do that, to have pre-orders, is the technical term. You could have your book available for pre-order. I believe though any sales made within that pre-order period doesn't count towards the ranking after the book's been ranked. That's not going to help a lot with regards to your ranking afterwards, so you do want to make a lot of sales, if possible, on rank day. What I'm going to do is make my hard cover version and my Kindle version available on December 10th when it launches. I'm in the process of doing a quiet launch for the paperback version. That's going to be publicly available hopefully within the next few days. We're recording this on the second of December, so it'll be available a few days just before the 10th of December if everything goes according to plan. Then I'm going to get a few friends and colleagues to buy it, and to publish reviews on that version. I'm going to have that linked together with the hard cover version and the Kindle version, which is going to be then published on the 10th of December. Kathleen: That's great. Well, I can't wait to check out the book when it comes out. Again, if you're listening, you definitely need to go to MarketingNowBook.com so that you can sign up to attend the live stream. This has been so interesting, David, just hearing this whole process laid out. While I think you've made it clear that obviously writing a book is no easy undertaking, and I think it's important to understand, but I also feel like you've made it very accessible in terms of understanding the process of bringing a book to market. So, I appreciate that. David: Yeah, hopefully a couple of people give it a go. It's not easy, but if you plan it out beforehand, then you can save yourself a bit of heartache, perhaps, that I've gone through. Kathleen's two questions Kathleen: Yeah, that's great. Now I have two question I always ask my guests, and I'm curious to hear what you're going to say. We talk a lot about inbound marketing on this podcast. Is there a particular company or individual that you think is really killing it right now with inbound marketing? David: The company that springs to mind is a company called Conversion Rate Experts. They've been doing this for a while. What they do is they put together blog posts that are on a fairly infrequent basis. They probably publish maybe just once every two months or so, but they are incredible case studies that really help you with conversion rate optimization. Although these blog posts are thousands of words long, they've got videos in there, they've got wonderful images in there as well. You feel that you're getting a lot of value from that. Towards the bottom of the page, they say what you should be doing now. Then they've got a list of call to actions at the bottom that introduces you to their service. But it never feels like they're asking for the order beforehand. They're providing so much value beforehand, and they link up lovely emails with this as well, and entice people to read the articles. I think that a lot of marketers haven't necessarily got the right idea of what a blog is. A lot of blog publishers don't have this sense. Obviously, blogs originated from web blogs, which were regular updates of people's activities. To me, a blog is just a publishing opportunity. It's a CMS now, with some marketing opportunities baked into it. It's just a publishing opportunity. If it's a publishing opportunity, you can publish any type of content in there, and I think this company, Conversion Rate Experts, demonstrate that a blog can be used for different reasons. Kathleen: I love that point that you just made about a blog being a publishing opportunity. The last job that I was in, I was really charged with building out essentially a brand publishing business for the company, which is really just like a blog on steroids, if you will. It's articles, it's podcasts, it's all the different type of content that you think of when you think of a publisher. There's no reason that any company can't do that. It's certainly a more aggressive approach to content marketing, but it can be a very powerful one, all of which lives on a blogging platform. Kathleen: So, you're absolutely right when you characterize it that way. David: Great. Kathleen: Love that. Now, second question, the world of digital marketing is changing at what can seem like a lightening-fast pace. How do you personally stay educated and up-to-date? David: Funny enough actually, since I've started being really serious about podcasting in the last five years or so, I've probably read less to keep myself up-to-date with things. I've interviewed about 500 or so different top marketers out there, and that's been a wonderful way to keep up-to-date with things. I would say to people if you haven't started a podcast, simply do it to have great conversations with powerful authorities within your niche. I would have done all these podcast episodes with a view to just having the incredible conversations, and making incredible contacts that I've made. Obviously, not all my guests would have wanted to do that. They would have wanted to have the content distributed as well. But for me personally, that's been a great source of knowledge. I listen to a couple of podcasts as well. I listen to a podcast called Podcasters Roundtable, which is a good source of podcasting news, what's happening in Apple Podcasts, and podcasting in general. I listen to Mixergy, which is more of a digital business/entrepreneurship-type show, but that's a great source of information for me with regards to what's happening right now in digital businesses. Then I could tie different marketing activities up to that. The final source that I'll give you, if I'm hosting shows that relate to SEO and pay per click, then Search Engine Land is probably one of the key blogs that I go to, to keep abreast of the latest news there. Kathleen: Yeah, that's a great one. You are preaching to the choir when you talk about the power of podcasting. I always say if people listen to this, they've probably heard me say it several times, that I would keep doing the podcast even if no one listens, which as you pointed out, I'm sure my guests would not want that. It's an incredible learning experience, and I get to talk to people I would never otherwise meet, and to learn from them. That's just such an amazing gift, so I could not agree more with what you said about that. David: Absolutely. How to connect with David Kathleen: Well, if you are listening and you are interested in connecting with David or learning more, David, what's the best way for people to get in touch with you? David: I've got a brand new domain name that I just acquired a couple of months ago or so. Obviously, I'm using MarketingNowBook.com as the landing page for the book, but I'm really happy that I've finally got the DavidBain.com domain name. It took me a long time to get that. There were many people that squatted on it for a while, but I eventually got it. I had to go down to auction to get it. I'm thankful to have David Bain on LinkedIn, David Bain on Twitter, and DavidBain.com as well. I guess any of those areas are good. You know what to do next... Kathleen: That's great. All right, well if you're listening and you liked what you heard, you learned something new, please head to Apple Podcasts and leave a five star review for the podcast. That's how new people discover us. If you know somebody else whose doing kick ass inbound marketing work, Tweet me @WorkMommyWork, because I would love to have them be my next interview. Kathleen: Thanks so much, David. This was a lot of fun. David: Great to be on with you, Kathleen. Thanks again. Kathleen: Yeah, and you win the award, by the way, for muscling through more dog barks than any other guest. So, kudos to you. David: Sounds good.

This week, we cover a few stories on oil and gas exploration, governmental intervention in the oil and gas industry, and some recent H2S-gas deaths in the Permian.Get Nate wet:https://www.linkedin.com/feed/update/urn:li:activity:6593170169638502401(But don't, actually -- get all of your friends to review the show and get Ryan and Josh wet, too.)Help get Carl Icahn on the Texas Oil and Gas Podcast! - https://www.linkedin.com/posts/ryanraysr_texas-oil-and-gas-podcast-on-apple-podcasts-activity-6566108936435486720-2t0tConnect with Josh on LinkedIn - https://www.linkedin.com/in/josh-shelton-55925288/Connect with Ryan on LinkedIn - https://www.linkedin.com/in/ryanraysr/The Texas Oil and Gas Podcast on LinkedIn - https://www.linkedin.com/company/35588693/admin/We're looking for a new sponsor! Get in touch with us TODAY for a proposal - nate.hansen@gor2.comLeave a 5 star rating and review! - http://apple.co/2mkM3ASContact the show via text or voicemail - 318-599-9192Visit our website - http://www.texasoilandgaspodcast.com/Connect with Ryan - http://bit.ly/2lLX1uhConnect with Josh - http://bit.ly/2W90MgrBuy Ryan's book - https://amzn.to/2CBOtAoGet an interview on the Oil and Gas Contractor's Connect Podcast! - nate.hansen@gor2.comThis week's articles:https://cbsaustin.com/news/local/west-texas-man-killed-by-poisonous-gas-wife-dies-checking-on-himhttps://oilprice.com/Energy/Energy-General/Democrats-Just-Accidentally-Sparked-A-Federal-Fracking-Boom.htmlhttps://oilprice.com/Energy/Energy-General/Texas-Hit-Hard-By-Shale-Slowdown.htmlhttps://oilprice.com/Energy/Energy-General/The-Biggest-Oil-Gas-Discoveries-Of-2019.htmlhttps://quickelectricity.com/texaselectricity2020/https://www.mysanantonio.com/business/energy/article/Drilling-Down-Callon-Carrizo-drill-up-to-last-14566118.php

This week, we cover a few stories on oil and gas exploration, governmental intervention in the oil and gas industry, and some recent H2S-gas deaths in the Permian.Get Nate wet:https://www.linkedin.com/feed/update/urn:li:activity:6593170169638502401(But don't, actually -- get all of your friends to review the show and get Ryan and Josh wet, too.)Help get Carl Icahn on the Texas Oil and Gas Podcast! - https://www.linkedin.com/posts/ryanraysr_texas-oil-and-gas-podcast-on-apple-podcasts-activity-6566108936435486720-2t0tConnect with Josh on LinkedIn - https://www.linkedin.com/in/josh-shelton-55925288/Connect with Ryan on LinkedIn - https://www.linkedin.com/in/ryanraysr/The Texas Oil and Gas Podcast on LinkedIn - https://www.linkedin.com/company/35588693/admin/We're looking for a new sponsor! Get in touch with us TODAY for a proposal - nate.hansen@gor2.comLeave a 5 star rating and review! - http://apple.co/2mkM3ASContact the show via text or voicemail - 318-599-9192Visit our website - http://www.texasoilandgaspodcast.com/Connect with Ryan - http://bit.ly/2lLX1uhConnect with Josh - http://bit.ly/2W90MgrBuy Ryan's book - https://amzn.to/2CBOtAoGet an interview on the Oil and Gas Contractor's Connect Podcast! - nate.hansen@gor2.comThis week's articles:https://cbsaustin.com/news/local/west-texas-man-killed-by-poisonous-gas-wife-dies-checking-on-himhttps://oilprice.com/Energy/Energy-General/Democrats-Just-Accidentally-Sparked-A-Federal-Fracking-Boom.htmlhttps://oilprice.com/Energy/Energy-General/Texas-Hit-Hard-By-Shale-Slowdown.htmlhttps://oilprice.com/Energy/Energy-General/The-Biggest-Oil-Gas-Discoveries-Of-2019.htmlhttps://quickelectricity.com/texaselectricity2020/https://www.mysanantonio.com/business/energy/article/Drilling-Down-Callon-Carrizo-drill-up-to-last-14566118.php

This week, we talk with Chad Collins, owner of Kingdom Chemical in Denver. Chad talks to us about oilfield chemicals, H2S treatments, and the science behind a lot of his chemical treatments. Chad also talks with us about how his chemical treatments can be used as drilling mud additives.EcoRidge, LLC. - https://www.ecoridgellc.com/Call Chad - (720) 737-1398Email Chad - ccollins.chad@gmail.comConnect with Chad on LinkedIn - https://www.linkedin.com/in/chad-d-collins-4758a85b/Careers in the Oil and Gas Industry - https://amzn.to/2mLCY4XConnect with Ryan on LinkedIn - https://www.linkedin.com/in/ryanraysr/Visit R-Squared Global's Website - https://www.gor2.com/Interested in coming on the show? We'd love to have you! Get in touch with Nate at nate.hansen@gor2.com for an interview.

Hey guys, Brandon Olson here. We got another episode of Rank Daddy TV. There’s a cool guy. Today, we’re going to do something a little different. I’ve never let this go to the public. This is something that we do for our Rank Daddy members. We have regular Zoom trainings. We set up a live conference, a live Zoom. Let you get on if you’re a member, ask questions in real time. We can cover topics, maybe you’re having issues. Cover an issue in your SEO agency or maybe in your prospecting. Whatever it is, it’s wide open. It’s question and answer and there’s also some things that we see maybe regularly. Topics being discussed in the Facebook group, so we’ll address those so everybody’s on the same page. Everybody’s successful. Everybody’s able to scale and continue to grow their SEO agency. I’m going to let you guys in. We just recorded one and it is live now in the Facebook group but I’m going to go ahead and put it on YouTube and stream it into this podcast video so you can actually see a little bit more about what you get when you join Rank Daddy Pro. There’s so much value, it’s insane. When you join Rank Daddy, you can come in for a dollar, you get more value for that dollar than you’d ever get on any other training platform you’ve ever bought, in your life, guaranteed. 30 days later, your $1.99 membership fee starts. If you haven’t landed a client 45 days following the process of at least $500 or 1,000 bucks a month, I will refund the first $1.99 thing. We literally give and give and give and we’ll give you complete access to everything, for a dollar, so you can test it and see if it’s even going to work for you, before you decide to even start paying or continue with the course. It’s not like you’re dropping four, five grand, on a high ticket course. Which is what this is, without seeing inside first. Flipping the script on the digital marketing space. You’re in for a dollar. We want you to land deals. We’re going to teach you and take you step-by-step, by the hand, how to land clients. Use the client money to pay your $1.99 for Rank Daddy. To cap ongoing education support and stop whenever you want. Go into your dashboard, hit “cancel” whenever you want to bounce out and you’re done. Let’s get started. Let’s take a look at what we covered on today’s Zoom training. Let’s go. Here’s the question; how can marketers like us, working only part time, and running our entire business from our laptop or smartphone, how are we able to guarantee insane results to our clients when the mainstream internet marketing gurus say that guarantees are impossible? That’s the question and this podcast will give you the answers. My name is Brandon Olson and welcome to Rank Daddy. We’ll have some more join but we’ll go ahead and get started. Been a lot of new members coming in. A lot of common questions that we’re seeing so we’ll address some of those tonight. What’s one of the first things you can do … and, everybody’s muted right now but, when you comment, you can just unmute yourself so that way, we don’t have a lot of background noise. Say, you come across an issue. It can be prospecting, it can be whatever, part of the SEO process, what’s one of the first things you can do within the Facebook group to find the answer before you’ve even asked it and typed in as a post? Anybody? Somebody’s on the chat. Use the search function. Very good. Use that search bar. Whether you’re on mobile, whether you’re on desktop, if you want to find out all the different posts that people have mentioned or we’ve talked about about client landing and prospecting, put prospecting in there. You’ll get a wealth of information. This groups’ been open for well over a year now so there has been a lot of deep discussions on practically every topic that’s covered in the training. Sometimes, the search feature doesn’t work all that great. I’m trying to find posts that I made months back, trying to remember different words that were in there. Sometimes it doesn’t work so it’s not to solve all problems but if you’ve posted a question maybe, and you haven’t gotten the answer yet, start digging. Don’t wait for the answer to come to you. Use Google or use the search bar in the group to see what others have put about it. Second thing, contest. The contest for March is going really good. There’s actually a pretty close tie for the number of spots. It’s not performance based so literally, the newest guy coming in can win. It’s not based on, okay, Ed’s going to take everything because he’s landing six deals a week. We’re going to give away 100 bucks to 10 different people and a thousand dollars to one person. Every time you place an order on SEO Outsource or Localize, we’re tallying it. It can be press release, it can be citations, whatever. If you are a 10 pack or five pack of PBNs, you get a 10 entries or five entries. We’re mentally putting them all on a spreadsheet and at the end, we’re actually going to print them out, put them on paper, cut them up and use a fish bowl or something. We’ll probably do it live here on a Zoom or Facebook live in the group and announce it ahead of time so we can randomly draw the winners out of that. We’ve never done anything like that before. It’s always been performance based but it’s almost unfair to some of the new people coming in, to do it like that all the time because you got all these leaders who’ve been in here since the beginning, that just dominate everything. This is kind of a fair way to do it all. What else? What else? An other topic that has come up quite a bit, you’re coming into the training, seems like there’s so much to learn. You’ve got WordPress. You’ve got content. You’ve got how to build Web 2.0 sites. You’ve got on-page SEO, which is daunting all by itself. I’m going to open this up to you guys, what do you want to master? What do you learn? What is necessary to learn on all these things that are covered in the training? Anybody got any ideas? Hey Brandon, I’ll step in real quick. Yeah. A couple things for me. I was in the last Zoom call but to just get more clarity. I’ll just start with some of the basic, simple steps like; just setting up your payment plan to receive a payment. Following that step right there. That’s a good one. Maybe also like, for me in my situation, my challenges, follow along, because I work so much. I really only have two days, like Monday and Tuesday, that I can actually do this business but during the week, I get up at 5:00 but I don’t get home until about 7:00 at night so as far as follow-up, teaching maybe an email. I’m not good at writing but maybe some basic way to do follow-up through email. Something like that, simple like that. Here’s the subject line and then here’s a basic, two or three sentences that you can send this day and then two days out, then three days after that, as a follow-up. I think that would be really helpful, at least for me I think. That’s good. As far as the process goes; you land a client, you immediately, obviously, have to do on-page SEO first. Do you have to be a master at SEO and on-page, before you can get past that step? The answer is no. A lot of people are coming in … The things that you touched on are critical. You obviously have to know how to setup the credit card process or whether it’s your Square or however you’re going to take payment and you should do that before you even start prospecting. Somebody out there is like; “I got a guy, he says yes. What do I do now?” “Well, send him an invoice.” “How?” Oh, yeah, rewind. You should already have done that. You got to have processor if you’re going to actually want to take money from people. That’s something you have to do. It can’t be outsourced. That’s what I’m hinting at. All these steps in the training, you do not have to be a master at. You don’t even have to know it. You have to know the steps in order to educate a person on the SEO process and what’s going to happen so that they know what to expect but you do not need to know how to do the on-page SEO yourself. You do not need to know how to build WordPress sites. A little bit of editing and things like that, that’s great knowledge to know and that’s about my limit. I don’t know anything other than the basic stuff that the tools show, for on-page SEO. Like; finding their title and their H1. Yeah, I can go into WordPress and edit those things but I’ve never opened a screaming frog, ever. All these tools, I’ve never touched. Here I am, with a massive SEO agency and teaching hundreds of people how to do the same thing, successfully. How is that possible if I don’t even know how to do it? Because I’ve got steps in place that I know work, that we have quality control over, that you don’t have to rely on learning everything and become a master at everything to move forward. Many are coming in and they’re saying, “Okay, this is overwhelming. I got to learn WordPress. I got to do all this.” You don’t. You’ve missed probably one of the very first videos on it and maybe we need to mention it more clearly through the course. I know Kevin did it in the on-page. Look, if this is overwhelming, you do not have to know it. Just know that step one is on-page. Just know that step two is, when the on-page comes back, it’s press release and so forth. As long as you know what order of what has to happen when you land a client, you’re golden. We know that when we land a client, on day one, like when we get their money. Okay, their money hits our processor, hits our bank, we can now order on-page. We can order citations. We can order web 2.0 to start. We can’t order press release until the on-page comes back. We can’t order social signals until the press release comes back because it has to create a natural flow. The on-page is there so that it communicates with Google, they know what the page is for, what it’s about, what it wants to rank for. The press release, once that’s done, starts that foundation for trust. 500 or so media links all with massive trust, coming to the site. Once that’s done, you run the social signals, which creates the viral activity of all that news that was just put out. Google sees all these steps and they see how they happening in the natural order. That’s why the course is there and laid out in this order, because it creates a natural scenario of what would actually happen in real world, to a business who actually ran a press release, who actually did these things, that naturally builds trust. The web 2.0 are there and they’re just consistent until you get the guide glued to the top for multiple editions, then you can back up on your web 2.0 because that’s your link diversity, your link consistency because they’re coming in five days a week, or however often you have your VA build up. They’re coming from trust, they’re coming from … do follow links are coming from no follow links are coming from … some of the platforms have little trust, some have no trust. Some have a lot of trust but that’s the diversity. Google doesn’t want to see all home run links. People come into this and they’re like, reads through the course and then they’re like, “Okay, I’m going to start building PDNs and then I’m going to shoot 10 to this client and that’s a massive amount of trust.” Yes it is but what else is it? It’s a massive flag. It wouldn’t be natural for a landscaper in, whatever city, Plano, Texas, to suddenly have 10 massive PBN powered links that looks like they’re worth a thousand regular links all at once. Figure out what you want to learn and what you want to do. Some people like their on-page SEO. They like the technical stuff. Some people like the content writing. I just got to the point where I like to land clients so that’s why all the outsourcing stuff is there on all the other steps. People are also asking, “Can we outsource the prospecting part?” Guys, I’ve tried and tried and tried, spent thousands of dollars on all these other job type of platforms, trying to bring in recruiters, 50% commission, 100% commission on month one. I mean, sales people are sales people. They want to be paid good and be able to then take a break for a few months and the money keeps coming in, residual. I’ve tried everything, so have a lot of the heavy players here in the group. We haven’t found anything that works. This is something you got to learn how to do because it almost is like, you need the dialogue. When you set out prospecting videos, not everybody replies the same. I’m sure you’ve noticed that. You’re going to get a lot of the same, common questions but you need the dialogue to bounce off so you know what to reply with. Pretty soon, it’s going to come natural. You’re going to know what to say, when to say it. Then follow through with another leading question, just to get to that point. Yes, it’s your destination. You’ve got to go through nos to get there. Don’t take no as personal or no as the end. Go to somebody else. No means, I don’t know all the information. I don’t know, how does it really work? How can I really trust you? There’s so many things that no could mean. Keep digging. Keep digging. Stick to the system. Micro steps. Another topic I wanted to cover. We’ve kind of touched on it in the group. When you’re sending a screen cast, and you shot your video, you’ve gone through Google or maybe you saw the signs on somebody’s truck, you got to prospect. You build a screen cast based on module nine, copy that model, extend it out. I would recommend using your personal email address, and I’ve tested both ways. I’m getting 90% or more open rate, sending from a personal email, using a simple subject line, roof repair. A lot of these new guys are coming in and they think they know. They’re like, all this crazy, guaranteed SEO stuff, tactics, white hat. No, they don’t care about that. That’s instant delete for business owners. I’ve done retail businesses for many, many years and we’re inundated. We’re inundated by SEO people claiming they know everything and they’re going to rocket our business to the top. None of them know. None of them know. Micro steps. The first goal is to get them to open the email. You want to be sending from personal email and you want a short subject line. Once that’s opened, second goal is to get them to watch the video. You don’t want to put a book there. “Hey,” and explain everything that’s in your video. Two short lines of text. “I saw your truck at Home Depot. I do computer stuff so I looked up your website and I found these two things that you can tweak real quick to improve your rankings, check this out.” It’s simple. Laid back. Nothing sales-y. No money mention. Nothing else. Don’t even talk about yourself for more than five seconds. Goal three now, is to get a reply. Goal one; get them to open the email. Once they open the email, second goal is to get them to watch the video. Short text that convinces them, “Hey, open the video. It’s just two short things. Tweak these things and your rankings are … It’s what I do for a living. Just helping you out.” Goal three is to get a reply. The video should be short, to the point. Do not talk about yourself for more than five seconds. I know people come in, they immediately want to start that video with, “I am Brandon Olson. I run SEO web consulting. I’ve done it for the last 10 years. I’ve helped 276 clients get to the top of Google,” and they’ve already left. They shut it off. They don’t care. It’s not about you. It’s about them. Immediately, go in and have that thing queued up to their homepage or their website. When they click play, they go, “Hey, my webpage’s here. What’s he saying?” Then they’re gonna start listening. Micro steps. Yes, we want to get that prospect and we want to see them to the end where the first thousand bucks are hitting our credit card processor, but we cannot do it on visit one. We cannot do it on email one, video one. It’ll take 10, 12 back and forths, sometimes before you even get a conversation started. At that point, they’re going to realize you’re so persistent, maybe this guy does know what he’s talking about. Maybe this girl does know what they’re talking about and then they’ll start asking questions. Now you can get to those questions one by one, answer them. Don’t bring up the money until they do. Don’t even mention the price. Price is another thing I want to cover. My pricing has always been population based. Some of you are probably in the accountability groups and have heard Ed with his pricing models. His pricing models are insanely powerful. He doesn’t leave a penny on the table because he introduced that prospect, he finds out how much the average client is over a year, whatever. He’s got a little formula that works perfect for him. If you want to do that, great, because it works, but it doesn’t work for me. That’s the point. There’s so many different ways to do things, to determine price. Mine is fast; land a client, get them started, plug them in, let my team start and I move to the next. I don’t care if I’ve left a little money on the table because three, four months in, if I only started a guy in a quarter million population, at a thousand bucks, and he’s a roofer, I know that once he starts seeing results and his phone’s ringing off the hook and he’s seeing his rankings shoot from page whatever, to page one in a couple of months then yeah, now he’s starting to see money come in from my efforts. Now I can always go back and say, “Okay, this is costing a bit. I know you’re getting an ROI because I see you got three or four different keywords on page one. Quality, competitive keywords. Let’s bump this up. I don’t mind adding other keywords for you.” That’s kind of the good thing about having Google Webmaster tools or search console installed right in the beginning. Because, once that thing runs for a while, and this is in, I think, module six about content, putting massive content on, running a Google Keyword Report after a few months in, especially once you’ve started the campaign, you might have started with five or six keywords but you can literally add dozens and dozens or even a hundred more keywords to your search tracker or whatever rank tracking program you’re using. You’re instantly going to see that they’re not just ranked for these five, six keywords you’re working on. They are ranked for dozens. 10, 20, 30, 50. All pages one through three or four but now you can take them, sort them by impressions and there’s a video in there that teaches you how to do this. I’m not going to go into that. Generate the report, get the list of keywords. Search them by impressions. That means; which ones are being displayed the most? Weed out the crap because there’s going to be stuff like popper sites that are helping you with restaurants and stuff that I don’t know why exists. These words aren’t even on my site. Delete that junk out. Put those keywords in your Rank Tracker. Now show your client, “Look, here’s what we’ve been doing. We’ve started with just a handful of keywords but now, suddenly, you’ve got two dozen ranked in the first two pages. Now we can take some of these and maybe run through our web 2.0.” Make sure they’re in the content, for the biggest part. You can use them for anchors but that’s not really the preferred method anymore, to rank keywords. If they’re in your content, especially if you’ve created new pages and you’ve done the meta and the H1 with those new keywords, they’ll start ranking automatically because you’ve already got trust going to the homepage. That’s kind of some things I wanted to cover. We’ll open it up. I’ve got some more things but I want to hear what you guys got to say. What kind of questions are you guys running? What do you want to do? Hi, I have a question. Yeah Maya. Hello, hello Brandon. How’s it going? Good. I have a question about on-page SEO. The new training is great but then, I’ve sent my order to SEO outsource but there are a few things that I will have to do myself because they don’t cover it unless it was already done on a website. That’s to install Google Analytics and submit a site map and what else? Google, let me see, register the website with Google My Business. I don’t know if that’s the same thing as … No, it’s not. No, that … Okay. All these all important for SEO or not so much or … Do you see what I mean? Yeah. For sure. Google My Business, 90% of my prospects already have a Google My Business place. If yours don’t, have them do it. A lot of guys in the group like to do that and take control of somebody’s Google My Business account. I’m not into that. It doesn’t matter either way. You can. It’s kind of based on their email address. Their company email address so they got to log in or whatever. It’s so easy for them to just do it. Okay. Yeah. Get the postcard and verify it. As far as analytics and site map, those are just simple plugins, normally, on a WordPress site. I don’t know how to walk you through it but if just post and tag Kevin, he’ll help you out. Yeah, yeah, yeah. No, no. There are ways to do it. Yeah. That’s fine. Okay. They are really through SEO. Yeah. Analytics got some great data in there so you can see visits real time. Keywords they’re pulling to come into the site. It’s a lot of good data that you may be able to share with the customer at some time. I don’t really ever get technical with my clients unless they want to. I’ll have it installed. My team installs Google … I keep saying Google Webmaster Tools. It’s now Search Console and it probably has been for years. Okay. Search Console and Analytics, right up front in the beginning so that any data that we need, we can get to at any point rather than customer ask a question, and then … Exactly. You can install Analytics and then we will have the information like, one months from now, when the thing crawls. Yeah. Okay. Thanks. Sure. I have a question. Yeah, who’s this? This is Miriam. Oh, hey Miriam. Hi. I just joined today. Yay. Quick question about on-page SEO. You’re talking about WordPress. I have a friend who’s just starting a moving business and his website is not on WordPress. That’s okay. That’s okay. All right. Good. Yeah. Depending on what platform it is, some of the platforms will allow to do quite a bit of on-page SEO. The most important things, obviously, are your meta tag. Your meta title and your H1 because those are the ones that are going to match your anchor for your press release. Okay. If you figure to how, just post in the group and tag Kevin. He knows practically, how to do every platform. He is fricking insane. I’m so glad we brought him on the team. He has helped us through stuff that I didn’t even know existed. Tag him and he’ll help you with that. For sure. Okay. Thank you very much. Yeah. Hi Brandon. How’s it going? Good. Mason. Yeah. I just wanted to ask about, more in depth, when you go on Search Console and you find a bunch of additional keywords that your client site has. If you see many keywords, how do you determine what to put on the homepage or what to build separate pages for or should you just build separate pages for each individual keyword that the client … For example, my client right now, I’m noticing, has 300 keywords and then, I was only targeting like five or 10 of them. Then there’s like 300 of them that’s showing up on Search Console and they’re all around position like, 30 or something like that. How do you determine what to … I notice that you talked about building separate pages for some of them and blog pages for some of them but some of them, I feel like, would need landing pages and, would you put them on the homepage. Yeah. How do you determine those kinds of things? Homepage is always dedicated to the, either the brand, if you’ve got a multi-site client. Or, the primary one or two keywords. Okay. Never go back and tweak your homepage based on keywords you’re finding in Google Webmaster Tools. Oh, wow. Okay. Okay. Because then you’ll start losing ranking for the main keywords because you’re telling Google, “This page is no longer about this. It’s actually about this.” It’s kind of a subtopic, which usually, is what the keywords are that you’re pulling out of there. I use them as extra landing pages but I first sort them. You’re sorting them by impressions. You’re getting rid of the stuff that’s way down past page nine and finding the ones like you’re seeing, around position 30 or whatever. Page three, that’s great. Delete out the junk and then maybe, copy those out and stick them in a spreadsheet and ask are client, “Are there any of these things you want to go for?” At that point, sounds like you’re kind of in the campaign, at least a few months, to be able to get that kind of report. Unless the site’s been up for a while and it’s got some trust on it, some age. It’s only been the second month in the campaign. The site’s been up for a couple months but for some reason, it’s popping up really well so I’m really good about that. That’s good. Yeah. As you’re building landing pages too, you have to take that list of keywords and group them together because you can use two, three keywords, or even more if they’re related. You want to max it out at probably two, kind of different keywords but everything that is in that list is kind of encompassed or maybe is a subtopic of that keyword. You can start using H2s and stagger your page out like that. I wouldn’t have multiple keywords that are different from each other. If they’re similar, group them together on a landing page and then make another set of landing page for the other group. You’ve got your title H1 as your main keyword, out of that 30 and then, if there’s five or so that are kind of related, plug them in there also. Have the content written and have H2s with those keywords. Google will find them and figure out what you’re doing, for sure. Okay. The keywords to use also, I’ve noticed, are local relevant and some of them don’t have the locality region in there so we should definitely use the local relevance as the … No, at that point, you won’t need it. Google already now knows, what your local relevance is. Now for these other pages, you don’t necessarily need cities in every one of your meta titles. Oh. Okay. You can have them sprinkled. It’s not going to hurt. It doesn’t hurt even if you’ve already done it but it’s not required. Okay. Once your homepage starts to get trust and Google knows what city you’re in and now you’ve got other H1s that are just keywords … If they know you’re sitting in Plano and you’ve got roofing and you’ve got another one for roof repair and insurance claims, they don’t have to be tied to Plano anymore because that is now under the hierarchy of what Google already knows your sites about. If they are. That’s okay. I see. Okay. Then, in terms of anchor text, from those inner pages to the homepage, is it important to have those specific keywords on that page, being interjected in the homepage? That’s debatable. I like to take and not anchor them all to the homepage but anchor them to one of the pages on the navigation bar or, in your list of service pages. You might have some linking to home because it logically links to home with whatever word you’re using or if it’s keyword or whatever, but some of the other words in your article may make more sense to anchor to one of your service pages or one of your pages about roof repair or whatever. They don’t all have to go to the homepage. The link just flows a lot better and Google can crawl it a lot faster and get the results to you faster if they are linking to one of the core pages. Also, linking to another page. You want to interlink those too so it’s kind of like, the spiders can crawl all over because you’re leaving them paths all over the place. That’s super helpful. Thank you. Yeah. You bet. Good question. Louis, are you raising your hand? Hey. How’s it going? It’s finally nice to hear you guys. Can you hear me? Yeah. Yeah. All right. Perfect. Perfect. Just wondering, I’ve gone to the course for about a week now and I’ve done a lot of heavy weight here and just wondering if there’s a plan in place because I’m doing the screen casts and I’m trying to figure out how to handle a phone call. For instance, I could email back and forth. I’m pretty good with the screen cast. I’ve been trying to push those out. I’m just worried about objections and maybe, how to handle clients when they call in, maybe start asking me a bunch of questions that I might get unfamiliar with. Yeah. Man, if they’re calling you and you answer it and you don’t let it go to voicemail, you’re going to stumble through it until you figure it out. I used to let them always go to voicemail. Maybe they’ll leave me a question and I’ve got some information I can research before I call them back but soon enough, you get fluent with our language and really, the biggest thing is the SEO process. Man, if you can watch that video or get the script or whatever, and if you can answer and avoid so many questions that you don’t know they’re going to ask by just going over that. When they hear what you tell them, is going to happen, no matter what niche, “This is your process. This is how we rank sites on Google, on demand.” “We literally, will start and we’ll interview and we’ll look at your site and see. Have a professional writer write about you’re business. We’ll distribute that as a press release, to 500 TV and radio and newspaper type websites.” Just tell them that and that’s massive. I mean, you’re literally just walking them through what’s going to happen and then, by the time you get to the end, they have no more questions. Usually, they’re just ready to start. If they’re asking other questions, it’ll trigger stuff that you’ve gone over in the training and soon enough, you’ll get better and better and you’ll know even, what they’re going to ask before they ask it. There’s no way to know what they’re going to ask and if you’re going to be surprised at what there asking or even know the answer. If you don’t, say, “Hey, I’m involved in a network of hundreds of other SEO guys. Top, elite guys across the country. Let me run it by them and I’ll find out, what the best way to go is.” Great, great, great point. Would it be helpful to ask them a few questions? To get them … I always do. Maybe to find out where they’re at in their company. That’s exactly right. That changes the subject. That kind of shifts everything too. When they see that you’re more interested in them and what they want for their business than you are to talk about the money end of it, that’s massive to a business. When a guy’s sitting there trying to figure out how to help me grow my business and they’re asking me, “Would you rather have more residential clients or more commercial or whatever,” and you go through and figure out what they want to rank for, what they want to … more customers. What type they want. When you start getting into that, that really gets them to let their guard down too. Okay. You’ve been very helpful. I’ll DM you or … ask you for a few other questions later on. Thank you. Louis, you got one? You got your hand up there. Nothing? Okay. He’s good. Soaking it in. Who else? Hello? This is Dwight Norris. Hey Dwight. Hey, I have a question. I’ve been getting a lot of video watches from my recent screen cast, from local and non-local people. I’m wondering how I can go about following up about them because I can walk to the local one and the others, I can’t so I’m not sure what kind of strategy I should use. Okay. Maybe I misunderstood the question. You made a video and put it on your YouTube channel, you’re getting watches? On YouTube. Yes. Okay. The people watching are not in your local area? There’s one company that’s just a couple blocks from me and there’s two others that aren’t close to me that I can’t actually get to and speak to them face-to-face. You have an internet business so you’re not confined by … and a lot of people have to get past this in their head sometimes. You’re not confined by taking customers only where you live. I have had probably five customers from my city, for SEO. Everything else I’ve got, all over the states, Australia, Canada, everywhere. Followup by email, is what I recommend. I don’t normally call businesses, unless they’re really want to phone call, and then I will. I like everything back and forth in emails so I can remember when they reply. I can look at the strand and see what we talked about and keep going because some prospects will carry on for a couple of months before you really get anything going with them. You’re kind of building are pipeline that way. Yeah, if you’re getting views from other places, that’s great. That’s kind of a technique that we want to add to the training to show you guys how to build a YouTube channel and promote it like that to get people coming to you. You certainly don’t have to be limited to have customers only where you’re at. That’s why I started this. I wanted a business that I wasn’t tied to any geo, local area, I wasn’t tied to an office, I wasn’t tied to a time clock and I could literally do, and outsource every step of my SEO from my iPhone, from the Caribbean or Florida or Bahamas or wherever I was and they don’t know the difference. Okay. Thank you. Yeah. You bet. Hey Brandon, can I just … not going to ask a question but just kind of address what Dwight just said and maybe even Louis. Yeah. For sure. Because I’ve started using this more. I’ve been for about a month, been, I don’t know, and a half now, month and a half now, but I’m starting to realize; we have so much resources at our fingertips like what Dwight, you getting a bunch of views, which is great. A lot of people are sending out a screen cast, and getting your emails to be open but a lot are not necessarily getting their videos to be clicked on. They would love the fact to have like, even myself included, I’ve sent out probably, about 35 or 40 and I a lot of them have been opened but I think there’s only been three that have actually been clicked on to actually watch the video and I’m thinking, “Man, if they could only see the screen cast, they would open them up.” I’m really wanting to get better at those first two or three lines to be my body of the email, to get them open. Like Brandon says, just little steps. You got to just tweak a couple things. Keep it simple to get them to open it. For you, Dwight, I was thinking, why couldn’t you, as you’re already getting a bunch of views coming onto your site, why couldn’t you just send out followup, just like what you’re doing now, putting yourself on camera and just addressing the next stage in SEO process. Like Brandon says in the videos, we get addressed just the H1 and the meta title. The meta tag. Maybe number two, you address the situations. Number three, you address the not secure. Number four, you just keep going down the line. Addressing these certain things in the process and then that’s going to first of all, give them value. They’re going to see, they’re going to get familiar with who you are. That’s more and more contact with them so you’re getting that much more closer to closing them because you’re having four or five or six or seven different touches with them to where now, they’re going to ask you, “What’s the price for your service?” So on. You could just do it right there, in front of your camera, right there where you’re sitting right now, without ever having to leaving or ever having to pick up a phone. Oh thanks Andrea. I didn’t think about that. Getting value is definitely one of the best things that I could do. I think I’ll try to implement that with people that are actually viewing my videos. Well, along with that too, on the search, like Brandon said earlier, when we first started the Zoom, in search, if you could just type it in there, type in the search and asking followup methods. That’s what I’m going to do. Followup methods. I’m sure a bunch of stuff will come up because people have addressed this in the past. I have. That’s my challenge, is basically, a lot of the followup methods. I know I can do it. I’m not good at writing but I’m just going to go in there and get a bunch of different ideas and print it out in front of the main group because you’ll have many different people come at you with their different angles and you’ll be able to pick and choose what works best for you. Good stuff. Good point. For those of you who are doing this, saving your screen cast to your YouTube, it’s a great idea. Make sure you build your banner. Have a professional banner. Have it done on Fiverr or something or tag somebody in the group or post in the group. If you make a YouTube channel that’s professional looking and it’s got a link to your website in it and it’s got ways that you’re … I mean, you’re using that as another platform. Kind of like your web agency website, for people to contact you. Set it up as a business, your business YouTube channel. Now, all these videos that you’re showing local business owners. I mean look, after you do the 30/30, you’ve got 30 videos that you can plug in there. You can make playlists out of them. People are going to start finding these. Especially if you’re using keywords that local business owners maybe are searching for, in your title. Use it in your title and then the first line of your description and it’s going to help it come up the YouTube rankings. Another tip on tags for videos, and this works on anything. I use Rank Daddy Branded. One word; as a tag in every single video. When you see one of my videos, off to the side, you’re also going to see suggested videos. Some of them are going to be mine because Google relates videos. If a video plays, Google wants to immediately feed that watcher with something else that’s related. It doesn’t know what’s happening on the video. It only can go by text right? Maybe at some point, or maybe they’re working on it, I don’t know. Tags are heavy. Tags and hashtags. If you use one keyword that nobody else in the world who’s using so it’s unique to your video. Now suddenly, all 30 of your videos are related. If one’s playing and you’ve got a business owner that happens to find one, that thing ends and Google is now suggesting another one of yours so they’re going to watch that. Now they’re consuming all your content and they’re going, “Wow, this guy actually knows something that can probably help my business.” They click the little arrow down thing and they read the description. Make sure you got a clickable link in that description. Https://yourwebsite so that it’s clickable. When you do it, go through and make sure it works and it redirects to your business. Can’t tell you how many people have found my ways back to content me from YouTube videos. We’re still getting five or six joins a day, to Rank Daddy, from people finding the videos and it’s the same concept. They’re finding it, I make it easier for them to click and they are able to find brandonolson.com where they can PM me and ask questions and then get in the group or just join. Works the same way on SEO. Once the maps is all done out and finished, that’s, I think, another one of the trainings we’re going to put up. I’m working with another person in the group who is really knowledgeable about YouTube and YouTube ranking. We’ll probably make an add-on training for you guys, to help you with that because it’s just one more way to get in front of people. Google owns YouTube. You get a good YouTube video, it’s going to show organically in page one. I remember when I was really focused on trying to rank my agency website, I took up eight spots of page one. I took up two maps because I had two different addresses. One went to a post office and one was an actual business address. I had two websites, brandonolson.net and seo3.com. That was when Google plus was still up. I had two Google Pluses and I had two YouTube videos and like, it was plastering. Sadly, it’s rare for a business to start searching for local SEO and find people that way. I kind of gave up. I had some web 2.0’s ranked even, on page one. You can build web 2.0 websites and point other web 2.0 links at it and those will start ranking. There’s a lot of little techniques that you can use to get yourself out there, in front of people, so that you just got better odds at landing clients. That’s all it amounts to. Brandon, I just realized that you said I should have those public. I had it unlisted. I didn’t even think about that. Well, I’d put them on public. Now, if you get a business owner that says, “I don’t want that there,” then yeah, put it unlisted. Until then, you created that video, you’re just using their site as an example. I’ve never had anybody tell me, “Take my video down.” Kind of have to play that, however you feel about that. Do it. If I’m creating instructional videos and I’m using stuff that’s public information on the internet, I don’t see anything wrong with putting them on public. It’s already public, I’m just giving you tips. Something to think about. Why does a website rank at the top of Google? What has to happen for a website to rank? Needs trust. Yeah. Trust. Trust. Ultimately, actual web traffic is the strongest trigger. It would have taken trust to get it ranked to number one and now it’s got the most amount of traffic. This is why, as you go through your SEO campaign and you see that it’s so easy to take people from nonexistent or page four, five, six, seven, even three, to page one, super fast. 30 to 60 days. Now, when you’re on page one, the results got to trickle because now you got to beat the people who have actual web traffic. Web traffic, traffic coming to an actual website, people actually clicking on that and visiting the site trumps all the other search criteria. The more you put trust at it, trust will slowly overtake because now you’ve got trust, you’re on page one. Maybe you’re at six or eight or seven and you’re continuing to build trust with the process but you’re also starting to gain traffic. Now you’ve got multiple things so Google and their algorithm has to determine at some point, okay, these guys are almost break even with traffic. Your site’s a little bit more but you got a lot more trust signals so pretty soon, you’re going to bump a guy off. Yeah. Website ranks when it’s trusted. The end game is to get the traffic but you have to go through the steps. How do we get to the trust? The trust comes from the process. The trust comes, it has to be built in a logical, methodical, natural way. It can’t be gained or anything like that with Google. They have so many people questioning whether to spend a dollar to come into this program to learn because they’re afraid that what we’re teaching is shady techniques. I don’t know of any member past or present, who’s ever had a site slapped for a Google penalty or something, for doing something shady. The process brings trust. The site ranks for the words on the site. You’re building trust, Google knows what it’s about. Google is going to rank it because of the trust, for the words that are on the site and most importantly, for the meta title and the H1. Those are the two major things that tell Google what you want to rank for. What the site’s about. Many SEO guys are still under the misconception that a site ranks for the back link anchors that are pointed to that sit. They’re going out and they just massively build all these anchors that are Dallas plumber and Dallas roofer and whatever niche they’re in. It doesn’t work like that anymore. Those were off page signals but if you have too many of those, it’s obvious to Google, what’s going on. It’s obvious to us. We can look at a back linked profile and see that a site has been SEO’d because it’s not natural for 50% of all the links coming in to be the main keyword. It’s obvious what’s going on. Extensive research has been done by my team, by other SEO guys in the business, 70 to 80% of all the links coming in need to be either your brand, so your company name or a naked link, just the website. Rankdaddy.com. Whatever. Out of every 10 links, seven or eight of them have to be naked or branded. Google is so heavy on branding right now, try to squeeze the brand in the title. If you have room for your one main keyword and your company name, separated by the bar, do that because Google wants to start seeing brand mentions. Especially as the map training comes out and you’re going to see how important it is. It’s going to lend massively, to the trust factors coming into your site. Your site does not rank for the back links or the anchor text. It’s a massive flag if you just overdo that. What else? What else questions? Brandon. Yeah, Maya. In the training, Kevin mentions that if we don’t do URL of our website, we can find out if it comes up first in the searches. With the website I’m working on right now, it’s actually the website bookings.com that is first because well, it’s so big. That tells me that they’ve got more what? Pages or links? No, it’s a massively trusted site. Yeah. Yeah. But, you can beat it. I can? It’s there because nobody else has proven trust. We do this all the time. I’ve done resort things. We had a huge campaign for some resorts out by Disney and we were beating bookings.com, hotels.com and all these other things because, guess what? Bookings.com is a search engine. Okay. Google doesn’t want to give results to a search engine if they don’t have too. Cool. You have to prove you need to be there. Yeah. The other thing is, bookings.com homepage has a massive amount of trust. That’s right. That result that’s coming up is not the homepage, it’s one of the landing pages to whatever property’s on it. For sure. Yeah. It’s not as much trust. The top level domain has the trust but that page doesn’t so you only have to beat the trust that’s found on that page. Very easy to do. Okay. Brilliant. Yeah. Yep. Okay. Yep. I’ll work on that. Cool. What else? Stop me. Hey, there’s a post in the group and you’ve probably seen it. Just use the search bar. Bring on the objections. I just, I don’t know. It’s been months. I put it up there and I just said, “Hey, what are you guys running into as your prospecting?” I don’t know. There are probably 20 objections up there that me and some other guys have responded with what we actually say when that objection comes up. Look for that. Prospecting is the main thing. I mean, the process works. That’s not a question. It’s a matter of, “Now we got to get clients so we can just plug them in and make money and scale.” If we get good at prospecting and landing clients, the rest is game over because it’s literally, just plug it into the system and if you’re new, you do it by yourself. In 30 minutes, the whole month’s work for one client, and then you move on o the next one. Once you’ve got 10, 12, 15 clients now you can start looking at hiring VAs and sculpting and forming your team. Posting in UpWork for maybe SEO assistants and things like that and give them tasks and test them out. This is how I got my VA. Sakid, in the group, that you guys have seen post or reply every once in a while. I used to tag him. He’s been with me for over seven years. He started at $2 an hour. He’s in Pakistan. He now runs a team and we have offices in Pakistan. We have offices in Pakistan on the ground floor of the … I forget what building. He bought a house, a car. He’s got to be one of the highest paid guys in Pakistan. He runs a whole team there and he just started at two bucks an hour with me on UpWork and I gave him more and more responsibility. It’s real easy to take the steps in the beginning because it doesn’t take much time. Just focus on mastering and just, as much as you can immerse yourself on prospecting. Even if it’s taking other little courses or get on youtome.com for prospecting or other YouTube videos. There’s a lot of training on sales and closing and the more stuff that goes in your brain, the more that you’ll be able to use when it comes time to land a client. Even though, not that you’re using high pressured sales tactics but if you know how to deal with a client or a prospect, and how to walk them through the steps of a close so that they don’t feel like you’re trying to get them to sign their life away. It just gets easier and easier. I really, really like the video and I might need to redo it because I think it could be a little more clear. Think it’s either four or five. The five closes that are my go to closes. They guarantee … Man, I can’t even remember. I might have to pull it up. You know what I’m talking about, it’s on the blog. Episode four or five. What else? Any other questions? Yeah. I have another question about the objections post. I read it and I thought it was so good that I created a Word document with all the answers and I uploaded it. It’s in the … Oh, cool. Yeah. It’s in the group. It’s only the resources. Everybody can have a look at it. Files, in the Facebook- In files. That’s it. Yeah. Cool. There you go. That’s good. Yeah, because they were really good. You know how we sort of try to get them in and explain that we need two months for the site to reach page one? At first, I’m trying to, yeah, get them to try my services and once we get you to two months, I know they’re going to ask, “Tell me again. Why do I need to keep paying for SEO now?” I’m thinking one of the ways would be, once we’ve had a look at the competition and we’ve seen how many pages they have, how much more content and back links, I would say, we build up and we beat your competition. First, when you say … You’re probably not using this but it’s just maybe, how I heard it, it’s going to take us two months to get to page one. Right. I wouldn’t quote that because sometimes it’s slower. Okay. We got some clients that you have to just dig because they get stuck and their site doesn’t move past page two or three for some reason, for months. There could be little things on their site that Kevin will find. Anyway, but yeah. That can happen and when it does, you got to know what to say. I always, plant a seed in their mind in the beginning, not necessarily what I’m landing it but maybe after I send them the first report, after it’s been a month, I want to make sure they know how I’m doing this. I’m not going to use the PBN but I want them to know that it’s not necessarily hard work that’s doing this. They need to know that their site is being trusted, that we’re building and everything we do is to bring trust to their site. We own and maintain a network of sites that have a massive amount of trust with Google. I explain this to them so that they know because, if this ever comes up, I’m coming back to that. When they say, “Okay, I’ve been on page one for six months, why do I have to keep paying you?” Right. Yeah. That’s it. Remember when we first started the campaign, I kind of explained how we rank and hold your site there? We’re using that network of sites of ours. They’re very expensive to maintain. We add content to them. Run different hosting that not your average GoDaddy hosting, things like that. They cost a lot of money to build and maintain. We only use those sites for you. We don’t use one site and link to multiple people. That’s dedicated to you. For all of the links that come up to those sites, that’s hard cost for us, monthly. Your SEO fee is offsetting that. If you stop paying … Also, I’ve already told them that one link is like, we’d give you a thousand links all at once. If we’re six months in we they got 10 links coming out from these trusted, powerful sites that we’ve got, I ask them, “What is it going to look like if you stop paying and we delete your anchors or your links because we have to use them for another client that is paying to offset that? What happens? What’s Google going to see?” They’re going to see thousands of links leaving your site. Which is going to do what?” You get them to thinking. They’re like, “Oh yeah. No. Don’t. Let’s not even go there.” Plus, I say, “I mean, you’re paying a thousand bucks a month, you’re getting an extra 10 grand in revenue,” or what ever it is, “When do you stop that?” There’s ways to do it without threatening them. I like the reminder thing but in order to do the reminder, you have to have already explained to them how you’re doing it. I never use the word PBN because they may start looking it up and there’s so much bad press on PBNs. Oh, I see. Okay. PBNs are dangerous if you don’t know how to do it properly. Screw somebody’s site up. Yeah. Yeah. Good question. Okay. Thank you. Yeah. Some of these questions, and I’m glad we’re doing these Zooms because it’s so much more effective to hear an explained answer than to read it in a post comment. It’s hard for me to get all those words in that comment and make them make sense. Glad you guys are here. Anything else? We’re going to wrap it up. Quick question, if it’s all right. Yeah. It’s Miriam. Okay. It’s sort of a sales question, sort of. I recently spoke to somebody who right off the bat, told me he was window shopping. Just talking to a few different people, and that’s fine with me. He and I are in another group together and I thought, “Okay, let’s just spend some time getting to know this business.” Ask them a lot of questions. Give them a lot of general pointers. Then they’ll send me a proposal. After I went through in detail like steps and blah, blah, blah and at that point yeah, okay. I could send them a proposal but my gut reaction’s like, nah, I don’t want to send proposals. I’m just wondering, in the training, do you cover that? To me, I don’t want to work with somebody’s who’s like, “Ah, I got to think about it again.” We already went through your entire financials. You know that this is the only way you can do this. I don’t know. Do you cover that? Yeah. I never, ever, ever sent a proposal. I’ve never sent a contract in writing. I am as simple as, okay, it’s all back and forth. I’m answering your questions. You’re asking. At some point you’re going to ask a price. I’m going to tell you how much it is, I’m going to tell you what we do. I’m going to tell you what the SEO process is and that’s it. As soon as you say, “Yeah. Okay. Let’s do it.” I’m going to say okay. I’m going to send you an invoice. Fill out this form, which is my intake form and then I’ll send you an invoice and we’ll get started. That’s it. It’s all by email anyway. It’s it’s in the email. I don’t do formal proposals. I just tell them. There’s no point because I’m not making you sign a contract. You can literally stop whenever you want. I want them to feel like they always have a way out. Okay. Okay. Yeah. Okay. That’s a little been another question. That’s great. No contracts. Yeah. Just month-to-month. The only time I ever did a contract, we had a state wide insurance deal. I was partnering with a guy in Florida and they required it so I made him do it and we did it. All these thousand dollar a month deals are all no contract, stop whenever you want, because I want them to feel like they have no pressure and they’re not locked into something. They just need that. Even though we’re giving them that, we still remain in control because our network of incredibly powerful sites are holding their rank to the top and once they’re in month two, three, they’ve already seen their rankings launch to the top. Now they’re starting to see customers from our efforts and that’s why we’ve got a 90% retention rate, because it works. It sticks. Yep. Okay. Thank you. Good question. I was talking to my brother the other day. He’s in the group. We were talking about business and, this is going to apply to a lot of people in the group because we have such a diverse group here. It’s about branding yourself and not compromising or bending or folding or getting forced into a mold that you think some business needs you to be or act or dress or live in a certain place. He’s from Arkansas and he has this “Good Ole Boy” accent and he’s like, “I just want the type of client that I can go and we can have a beer after work.” That’s the type of clients he’s attracting. There are millions of businesses across America that want to deal with that kind of a person. If you’re that kind of a person, great. Don’t think you have to change to fit in the SEO mold. The SEO agency mold. Maybe you live in another country. Maybe you have a thick accent. Maybe your hair’s long or maybe you’re like me and 90% of the year, you wear shorts and flip flops. If a business owner’s not okay with that, that’s okay. There’s more businesses to catch. I guarantee you, there’s millions of businesses that are okay because I still know enough to 10x their business while I’m wearing my shorts and flip flops and doing all this from my iPhone. Don’t think you have to fit into a mold. Brand yourself. You look at the Rank Daddy logo, that’s me. Shorts and flip flops. I’ve gone to meetings like this and gone to clients in this and landed them. It doesn’t matter. If they have a problem with it, they’re not going to sign up and that’s great. You move on to somebody else. Just knowing that you can be whoever you are and do this business is a great feeling to me. Last thing I wanted to cover, Lebron James recently broke Michael Jordan’s record, right? I don’t know a lot of the whole stats and everything but this is about modeling someone or something that is successful if you’re trying to reach that level of success. There’s no reason to reinvent the wheel. There’s no reason to try to figure it out on your own. If you want to be successful at something, the fastest way, and Tony Robin says this, is to find somebody who’s already done it and model exactly what they did. Lebron, as a child, would buy packs and packs of basketball cards, hoping for a Jordan. He would study every aspect of Jordan’s game. Down to the way he wore his calf sleeve and turned it inside out so that the red lining showed. He studied and imitated. Drew profound inspiration from his … I’m reading this from an article that I read because it was so cool, his tongue wagging dunks. His fade away jumper. His competitive fire. The little details of the way Jordan wear his sneakers and shorts. Lebron, he admits he didn’t think he could be like Mike but yet, he modeled him. Does that mean you don’t have to put in the work? No, because he worked his butt off. Same with your SEO agency. You have to put in the work, even though you’ve got a system that you can plug into and model exactly, to get the results that so many in the group that are finding success, have done. Don’t veer. There’s no reason to make a step 3.5 and plug it in because you think it should go there. Doesn’t need it. We’ve done this on thousands and thousands of site already. It works. Follow the model. That’s it for today guys. We’re a little over an hour so we’re going to cut it there. I appreciate you guys. You find value in any of this, go to one of my YouTube videos and leave a comment like Andrea and a lot of these other guys. I appreciate you. Thank you so much for being here. I’m humbled at all of this. Love the group. I love the interaction, the engagement. Let’s keep building. Keep leaning on each other. We’ll get there. Ya’ll have a good night. Thanks Brandon. Bye. Thank you. Bye. Thank you, thank you. Thank you Brandon. Have a good one guys.

In this episode we unpack what SEO is and how you can use SEO efforts to drive more traffic (and more of the right traffic) to your nonprofit or foundation website! What is this mysterious SEO and why does it matter for nonprofit organizations and foundations? SEO feels a little like the great and powerful Wizard of Oz -- everything happens behind the curtain and the Wizard claims he can somehow get your website to show up first on Google. And just like the Wizard of Oz, when you pull back the curtain, you’ll find the Wizard isn’t who you thought he was. And in the end, with time, a commitment and ongoing efforts, your organization can find its own way into getting more organic traffic from SEO efforts. Because many businesses and nonprofits got duped by shady SEO companies who happily took their monthly checks but didn’t ever share what SEO efforts they were actually doing each month, many organizations are now rightfully hesitant when it comes to SEO. But here’s the thing, optimizing for SEO does not have to be so mysterious.   What is SEO SEO stands for search engine optimization.” Basically, SEO is the process of getting traffic to your website from the “free” search results on search engines like Google and Bing.  Obviously, every nonprofit organization, foundation and business wants to be found easily on search (if not at the top of the first page). But there is alot of competition, so search engines like Google have to figure out which websites show up at the top. At the end of the day, Google’s reputation is based on quality search results so their algorithm that defines who shows up in what order is all about quality. So, if everyone wants their website to show up first, how do you get to the top? Why does SEO matter for nonprofits or foundations? Nonprofits and foundations generally rely on organic search for the bulk of their website traffic It’s important for organizations to make sure they are driving traffic (and the right traffic) to their site Organizations need to make it easy for search engines like Google to crawl their sites and find the right keywords Meta Descriptions should be written in a way that includes the right keywords BUT also gets the audience to click on the link to your website. How websites are ranked: You’ve probably heard the term algorithm when talking about Google. Basically Google figures out rankings based on a complex mathematical model which is called an Algorithm. This algorithm takes into account hundreds of factors when determining the ranking for any keyword. Google does not share what goes into the algorithm, but the practice of SEO has helped us make an educated guess on what many of those factors are: Content that matches a search (keywords) Content that is optimized on the site (keywords and meta descriptions created for each page) - keyword should be in the page name and headlines as well as within the content itself. A site that generates content on a regular basis (blogging) Secure site (does your site have an SSL) A fast loading website (check your page speed including mobile) Mobile-first site Domain age and domain authority (Moz score between 1-100) User experience Click through rate on Google Bounce rate - if people are leaving your site at a high rate it could affect your rankings How long people stay on your site Links (particularly on other sites that link to yours but also on your site) Business listings on search engines (Google business page, Bing, Yahoo, etc.) Social signals - shares on social media How to improve your SEO efforts YOAST - First of all, if you have a WordPress website, if you don’t already have it, download the Yoast plugin. There is a free one and a paid version. MOZ - If you have it in the budget, we’d recommend tracking your rankings in Moz. Your report also gives you insights each week for improving your site’s performance which effects your ranking. Check your site speed! Make sure all of your pages have designated keywords, and more importantly well-written meta descriptions. You really need to understand how your audience is looking for you. Make sure your H1s, H2s, H3s etc are set up based on hierarchy of content not just for design purposes! Here’s one that is all too often overlooked! The “alt tags” in your images should include keywords (needs to be authentic). Create relevant content on an ongoing basis (especially using keywords) - think blog posts and resources here! Resources Moz.com - Beginner’s Guide to SEO Yoast.com - Yoast Must Reads for SEO Google’s page speed test: https://developers.google.com/speed/pagespeed/insights/ Find your domain authority: https://moz.com/link-explorer

Dr Carolyn Lam:                                Welcome to Circulation on the run, your weekly podcast summary and back stage pass to the journal and its editors, and welcome to a whole new podcast format in 2019. Ha-ha, I bet that surprised you. Well guess what? This new format promises more interaction, more discussion and a whole lot more fun, and that's because to begin with, you don't have to listen to me talk to myself half the time anymore. I'm Dr Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore, and I am simply delighted that Santa gave me a partner on this podcast, and co-hosted with me, and my gift is none other than Dr Greg Hundley, associate editor from the Pauley Heart Center, at Virginia Commonwealth University Health Sciences. Welcome Greg. Dr Gregory Hundley:                       Thank you so much Carolyn. How exciting is it to start this new year with this exciting format, where we'll take several of the key manuscripts from Circulation and discuss them? Picking five each time, and as you've alluded to, we're not going to get rid of that favorite format, where we take a select paper and interview and work with the authors. Dr Carolyn Lam:                                Exactly. In fact, maybe I could liken it to welcoming everyone to join us over a cup of coffee, each week, with the journal in the hand and we're just going to discuss it, and never forgetting that feature paper with the authors, and this week's paper is huge. I love it. We're actually going to be talking about blood pressure control in the barber shop. But before then, here's the articles that we've chosen to discuss. So Greg, you got your coffee ready? Shall we start? Dr Gregory Hundley:                       Absolutely Carolyn, and let's get going first with Gorav Ailwadi, from University of Virginia, his paper evaluating the utility of MitraClips in those with secondary mitral regurgitation. This is really a follow-up from the EVEREST study. It's not a randomized trial, but it's a longitudinal look over time, at 616 patients. Interestingly, those individuals that had class three or four heart failure, that had the MitraClip, the left ventricular volumes got smaller in a year, the hazard ratio for events became less. The magnitude of mitral regurgitation went from 4+ down to 2+. Exciting findings. Dr Carolyn Lam:                                Interesting, but you know Greg, these all sound so positive. Why is it so different in the Mitra FR study?   Dr Gregory Hundley:                       Absolutely Carolyn. So, as you know, Mitra FR, that was a randomized trial. So, this study doesn't compare, the EVEREST study in this issue, doesn't compare with conventional medical therapy, that's number one, and Mitra FR did. Also, the Mitra FR patients were a little bit sicker. The ejection fraction really was 15 to 40 percent, and in the EVEREST study, much higher, average 45 percent. In fact, many had a normal EF. So it really raises a lot of questions as to whether or not this finding will hold up in future randomized trials, which we'll be looking to see the results. Dr Carolyn Lam:                                Indeed, and it was really nicely discussing the accompanying editorial wasn't it, which I really enjoyed. Well, the paper I picked out Greg is from Dr Gatzoulis from The Royal Brompton Hospital, and it's actually the MAESTRO trial. Now, MAESTRO is a randomized control trial of the endothelin receptor antagonist macitentan in patients with Eisenmenger syndrome. Short and long of it, macitentan did not show superiority over placebo on the primary endpoint of change in baseline to week 16 in exercise capacity. And there was also no relevant trends observed for the secondary endpoints.                                                                 However, among the exploratory endpoints, macitentan did reduce Nt-proBNP in the main cohort, and improved pulmonary vascular resistant index, and exercise capacity, in a hemodynamic sub-study. Importantly also, there were no specific safety concerns with macitentan. Dr Gregory Hundley:                       Sounds really interesting, Carolyn. But how did this compare with prior studies that have really focused on endothelin? Dr Carolyn Lam:                                Great question. So, MAESTRO's only the second randomized control trial of an endothelin receptor antagonist in Eisenmenger Syndrome. BREATHE-5 was the first, and this used a different endothelin receptor antagonist that was bosentan, also in Eisenmenger Syndrome, and actually found that bosentan reduced pulmonary vascular resistance as its primary efficacy endpoint, without worsening systemic pulse of symmetry.                                                                 So, very different trials in terms of endpoints, as you can hear, but also importantly, different populations that were enrolled. MAESTRO enrolled a more heterogeneous population with more complex forms of Eisenmenger, including patients with Down syndrome, had a broader WHO functional class inclusion, and allowed the use of pre-existing therapies such as PDE5 inhibitors.   Dr Gregory Hundley:                       That's really spectacular, Carolyn. Very interesting findings for something that these vasoconstrictors, vasodilators, often very harmful. Switching over, I've got sort of another paper that is also working on vasodilation, but comes really from the world of basic science. And it's from Ingrid Fleming from Goethe University in Frankfurt, Germany, examining how does hydrogen sulfide, a common gas that we have in the environment, it smells terrible, we worry about sulfuric acid and acid rain, but how does this promote vasodilation in the system?                                                                 And so, in this basic science study, they unlocked sort of a key that this hydrogen sulfide is produced by cystathionine gamma-lyase, CSE. And why is that important, and what does it do? Well, production of H2S by CSE goes and inhibits human antigen R, or HuR, that regulates cellular proliferation and growth. And so, basically these authors have unlocked a mechanism by which hydrogen sulfide can be protective.                                                                 So, what's interesting Carolyn is that patients can have elevated levels of L-cysteine, increased expression of CSE, so you've got the components and the manufacturer of H2S, but they still have low arterial levels. Dr Carolyn Lam:                                 Hm. So, how can this be addressed then? How can we raise that H2S? Dr Gregory Hundley:                       That's what's so clever that the investigators found out, Carolyn. They found a slow-release oral active drug, a sulfide donor called sodium polysulthionate, H2R, or sulfhydration, and can inhibit atherosclerosis development or progression when these levels are low. Dr Carolyn Lam:                                Indeed. sodium polysulthionate. Awesome, Greg! That is so cool. Honestly I just loved your explanation of that. Okay. Well, I've got another paper to share. And this is from Dr Bress and colleagues from University of Utah School of Medicine. And this one is really interesting because these authors estimated the number of cardiovascular disease events that could be prevented, and the treatment-related serious adverse events that could occur over ten years, if U.S. adults with hypertension were achieving the 2017 ACC/AHA guideline recommended BP goals, compared to their current blood pressure levels, as well as compared to achieving the older 2003 JNC7 goals, or the older 2014 JNC8 goals.                                                                 Now, basically they found that achieving and maintaining the 2017 guideline blood pressure goals over ten years could prevent three million cardiovascular disease events, a greater number of events prevented compared to prior guidelines, but this could also lead to 3.3 million more treatment-related serious adverse events. Dr Gregory Hundley:                       So, Carolyn, hasn't a main concern of this type of work been that these new guidelines over-extend the reach of our treatment? Dr Carolyn Lam:                                That's a real concern that I've also heard. The lower blood pressure thresholds used to define hypertension in the 2017 guidelines could indeed lead to more diagnoses. However, this paper helped because remember that the recommendation for anti-hypertensive drug treatment in patients with the pre-treatment blood pressure of 130-139 systolic, or 80-89 diastolic, was limited to those at high cardiovascular disease risk. So not everyone, but only those at high cardiovascular disease risk.                                                                 And so, treatment under the 2017 guidelines, by these data, would lead to more health gains, while only extending treatment to 5.4% more adults with hypertension compared to JNC7. So, this paper really modeled these things out with important contemporary U.S. adult populations using a national representative, a sample of U.S. adults, and NHANES, as well as REGARDS, and they also used estimates of benefit from the recent large meta-analysis of 42 blood pressure-lowering trials.                                                                 So, important data that I think are going to be reassuring to a lot of people managing these patients. Well Greg, that really brings us to the end of our little chat. Now, let's move to our future discussion, shall we?                                                                 Could cutting blood pressure in a barber shop be the long-term solution to hypertension in African-American men? Well, the future paper of this first issue in 2019 really talks about it. Greg and I are so delighted to have with us the authors of the paper, Dr Ciantel Blyler, and Dr Florian Rader from Cedars-Sinai Medical Center, as well as our associate editor, Dr Wanpen Vongpatanasin.                                                                 So, Ciantel, can you just perhaps start by telling us what you found. Dr Ciantel Blyler:                               So, what we're talking about today are the 12-month results as a follow-up to our 6-month results that we published earlier this year. So, we took 319 African-American men in Los Angeles County, and randomized them to two groups. One group saw a clinical pharmacist who worked with them to reduce their blood pressure, and the other group just worked with their barber to talk about blood pressure, and encourage usual follow-up.                                                                 And, as we saw at the 6-month mark, blood pressure really improved in the group that was able to work with the clinical pharmacist. So, we saw an almost 29 mm Hg drop in the intervention group, as compared to only 7 mm Hg in the control group. Dr Gregory Hundley:                       Ciantel, Florian, that is really exciting results. What is a collaborative practice arrangement, and how did you affect that in Los Angeles? Dr Ciantel Blyler:                               So, collaborative practice is actually widespread in the United States. California is one particular state that is kind of ahead of the curve with respect to collaborative practice between pharmacists and physicians. But what it essentially allows a pharmacist to do is to prescribe, monitor, and adjust medications underneath a physician's supervision. So, a document is drawn up, medications are selected, and an algorithm so to speak is put together so that a pharmacist can treat a patient independently of a physician needing to be there. Dr Greg Hundley:                             Very nice. And did you find in the pharmacist-led group that these patients were taking a different anti-hypertensive regimen, or were they more compliant? What do you think was the reason for the discrepancy in this magnificent blood pressure drop in this group of hypertensive men? Dr Florian Rader:                              So clearly, there were a lot of differences between the two groups. First of all, we had a protocol with our favorite blood pressure medications that we use clinically here in the hypertension center at Cedars-Sinai. Essentially it is long-acting calcium channel blocker, specifically Amlodipine, longer-acting angiotensin receptor blockers, or ACE inhibitors, and a third line, usually a thiazide diuretic, and also a longer-acting one, not the usual Hydrochlorothiazide, but specifically Indapamide that we used for this research study. Dr Greg Hundley:                             And do you think that there was more compliance in this pharmacist-led group? Dr Florian Rader:                              One would expect that. First of all, I think that seeing the clinical pharmacist, more frequently being reminded of taking the medications, having feedback by actually seeing the blood pressure numbers in the barber shop, I think would help. But then, in addition, we choose these medications not only because they affect it, but also because they're easy to take. They're once-a-day medications with very high continuation rates in larger studies, so they're just easier to take than other medications that are oftentimes prescribed. Dr Greg Hundley:                             It sounds like also, there might have been a trust factor. Because you're seeing the same person over and over in a very nice environment. Was that a factor?   Dr Ciantel Blyler:                               Absolutely. I think there's a different level of trust that's established when you meet somebody on their own turf. So I think the fact that we met men in barber shops where they felt comfortable, where many of them had been going to the same barber for over a decade, it made all the difference in terms of establishing a rapport, and gaining their trust with respect to having them take medications. So, I think that was a huge part of why we saw increased adherence, and really sort of a commitment to the program. Dr Greg Hundley:                             And we certainly recognize how harmful hypertension is in individuals of Black race. How does this group in Los Angeles translate to perhaps other Black men in the United States? Particularly, for example, in the South. Dr Ciantel Blyler:                               I think the program could translate really anywhere. I think what makes it so tailored to African-American men is this notion of going into a barber shop, which is a very important place in the Black community. So, again, sort of going back to what I said earlier, most of these men had been seeing the same barber as frequently as almost every two weeks for over a decade. So, it really helps increase the frequency with which we could interact with the men, and it helped with continued follow-up and adherence to the program.                                                                 With respect to the area of the country again, I think it translates. Dr Carolyn Lam:                                I've got a follow-up question to that, if you don't mind. So, I'm here listening all the way from Singapore, and I'm just so impressed, and frankly just enamored by this study. And wondering what is the barber shop to my local Chinese guy? I'm actually wondering if it's the kafei dian and that stands for coffee shop, and I'm also wondering what about the women? Wanpen, do you have any insights that you want to share? Dr Wanpen Vongpatanasin:         I believe that even Dr Victor had thought about the beauty shops, that is a barber shop study in parallel, and this could very well work very well. Who knows, we could be going to massage parlor, anywhere, that when we feel relaxed and be ourselves, we go out our way, out of our regular activity, and it could really be a neat idea. And for a study, I'm not sure I could do something out of the box. I would say it must have been successful as this approach, and partly it could be because of the additional pharmacists engage likely. So, I think this is a perfect combination. Dr Greg Hundley:                             Wanpen, you had mentioned Ron Victor. Maybe Ciantel, Florian, and Wanpen, you used to work with him. What did Ron mean to this study? Ron Victor unfortunately passed away this past Fall. Dr Florian Rader:                              Ron hired me almost seven years ago now straight out of fellowship. He was personally my mentor. He taught me all the tricks when it comes to the work of the management of hypertension, so personally I owe him a lot. Regarding the study, he's been thinking about this for a long time, this approach to hypertension management. He's tried it in Dallas. It worked partially, but not very well because he didn't have a pharmacist, and he didn't have somebody that made it their goal to lower blood pressure no matter what.                                                                 And in this study, we had somebody like that, the clinical pharmacist. So, Ron Victor has thought about this for a long time, has done a lot of analysis of the Dallas hypertension study, and figured out why it didn't work out in Dallas, and really cooked up a recipe for this trial, and the results speak for themselves. Dr Greg Hundley:                             Wanpen, do you have anything to add about Ron? I think he was your mentor as well. Dr Wanpen Vongpatanasin:         Absolutely. I trained with him actually from the internship until fellowship, and I owe my career to him. And actually, I see this idea stemming from the Dallas heart study when he did the survey, and realized that if you just wait for patients to show up in the clinic, that you're not going to get anywhere, because African Americans have higher blood pressure at a younger age, and are more susceptible for target organ damage. And as we all know, by the time many presented with, they already have end-stage kidney disease or cardiovascular disease by the time first presentation. So, to avoid it, we have to go into much earlier, not wait until they come to the healthcare facility, and I'm glad to see that this idea is really becoming widely successful more than anyone can imagine. Dr Carolyn Lam:                                What a beautiful tribute. What a poignant note. Thank you, all of you, for your great input, and for publishing this amazing paper with us at Circulation!                                                                 Thank you, listeners, for joining us today on Circulation on the Run with Greg Huntley and me. Thank you, and don't forget to tune in again next week.                                                                 This program is copyright American Heart Association 2019.  

Lees: When should we love them and when should we leave them? And what the heck is “lees” anyways? The main chat in this episode begins around 10 minutes in and features Curt Sherrer presenting his workshop titled “All Lees Are Not Gross”. This was recorded at the 24th Annual Franklin County CiderDays in November of 2018. Why rack off the lees? Curt proposes that there are more advantages for aging the cider on the lees then removing the lees. Sur Lie is leaving the lees in the vessel that you are conditioning the cider in is called: What to expect from barrel aging and leaving the cider on the lees is the smell of H2S which smells like rotten eggs. Curt recommends: Using your nose and taste buds to keep track of what is going on when leaving the aging cider on the lees. Taste every part of the fermentation Instead of automatically dumping your lees our of the bottle - save your lees add to your next cider cook with the lees make bread with lees The process for either barrel or carboy: After the rigours fermentation, stir lees for usually the next 6 weeks - sometimes 3 times per week. This technique is called Bâtonnage. Use your nose and taste buds to decider upon the schedule best suited for your cider. Perhaps you will stir more often or not. Lees can rest upon the bottom of your vessel for up to year for further. This presentation will “lees” you with lots of food for thought and decisions to make for you own cider. Not a cider maker? - then seek out maker who do produce cider sur lie and see if you like this more wine like production. I do and as such post this taping I began my own oak barrel sur lie cider. Stay tuned! Mentions in this Chat CiderCon2019 - February 5-8, 2018 Gift giving links mentioned in this chat go to http://ciderchat.com/resources/ Listen to episode 020: Curt Sherrer | Millstone Cellars FEDCO - Tree Catalog Listen to John Bunker episodes: 16: John Bunker | Super Chilly Farm, ME 028: John Bunker | Apple Identification Please Help Support Cider Chat Please donate today. Help keep the chat thriving! Find this episode and all episodes at the page for Cider Chat's podcasts. Listen also at iTunes, Google Play, Stitcher (for Android), iHeartRadio , Spotify and wherever you love to listen to podcasts. Follow on Cider Chat's blog, social media and podcast Twitter @ciderchat Instagram: @ciderchatciderville Cider Chat FaceBook Page Cider Chat YouTube Ask for the following ciders - By supporting these cidermakers, you in turn help Cider Chat Kurant Cider - Pennsylvania : listen to Joe Getz on episode 14 Big Apple Hard Cider - NYC : listen to Danielle von Scheiner on episode 35 Oliver’s Cider and Perry - Herefordshire/UK ; listen to Tom Oliver on episode 29 Santa Cruz Cider Company - California : listen to Nicole Todd on episode 60 The Cider Project aka EthicCider- California Albermale CiderWorks : listen to Chuck Shelton on episode 56 Cider Summit : listen to Alan Shapiro founder of this cider fest on episode 75. Ramborn Cider Co. Luxembourg. Big Fish Cider Co. Virginia Tanuki Cider Co. Santa Cruz California episode 103 Ross on Wye Cider and Perry, UK Process and Analytical NMR Services - John Edwards provides analytics of cider - stay tuned for his Chemical Fingerprints workshop coming up on Cider Chat Ironbark Ciderworks, Claremont, California Join the #ciderGoingUP Campaign today!  Haven't downloaded this chat yet? Here is is again.

买车心理学来自w奔波儿霸的雪球原创专栏$长城汽车(02333)$ 汽车作为大件消费，虽然一见倾心很重要，但大部分消费者在一见倾心之后，还是会做比较详细的对比，较少会冲动消费。所以汽车的营销就是尽量让消费者一见倾心，但更重要的是让消费者在详细对比后，仍然能够心甘情愿的掏出钱包。在这里提个问题，H2S比CS35颜值高，做工和质感也更好，技术性能也更强，为什么销量却差很多？H4和CS55相比也是如此。为何长城的车全方面碾压，却卖不过对手？详细对比后，就看出问题所在了。CS35手动档低配6.9万，H2S在拼多多前为8.4万，贵1.5万。H2S各方面全都碾压CS35，贵1.5万，值不值？有人可能觉得值，但更大尺寸的CS55也就卖8.5万。对于这个级别的消费者来说，多花1.5万，是更好的品质重要，还是更大的尺寸重要？显然是尺寸重要。CS55自动档低配卖10万，拼多多前的H4卖11.6万，也是同样的问题。多花1.6万，却仅仅是更好的品质，消费者不买账。H4的价格，可以买更大尺寸的GS4或CS75了，谁会去买H4呢。对于低端消费者来说，同样的价格肯定选更大的尺寸，这是第一定律。小而美是对抗市场规律。哈弗的H2S、H2、H4全都是小而美的定位，被市场无情的教育了。这个其实很好理解。假如一个屌丝，天天吃沙县，有一天心情大好，愿意在吃饭的时候多花10块钱庆祝一下，请问这个屌丝会在吃沙县的时候加个鸡腿，再点瓶啤酒，吃喝的心满意足，还是跑去吃逼格高一点点，但其实肉不多的味千拉面呢？到底是逼格高一点点重要，还是肉多、有啤酒重要？显然是肉多有啤酒重要。再来对比下H8 H9 P8和唐二代这四款车，H9和唐二代是成功的，H8和P8是失败的。原因在哪里？对于愿意花20万以上的价格来买国产车的消费者来说，一定要给他包括他的亲戚朋友一个显而易见的理由，20多万，为什么要买国产，而不是买合资？H8和P8都缺乏显而易见的特点，这俩车的综合素质优秀，但综合素质，无法说服消费者买20多万的国产车。一定得是显而易见的某方面的拔尖才可以。H9和唐二代则都做的比较好。20多万的价格，类似的尺寸，只有H9能带来如此的越野能力和动力性能，合资的竞品都30万以上，自主的竞品只有RX8，越野能力和动力性能都差了一大截。对于唐二代来说，4.5秒加速，100的纯电续航，秒天秒地，这就够了。20万以上的自主汽车，一定要各方面85分以上，某方面达到95分，才能够突围；如果是各方面都90分，缺乏拔尖项，则无法突围作者：w奔波儿霸链接：https://xueqiu.com/4097105650/114029476来源：雪球著作权归作者所有。商业转载请联系作者获得授权，非商业转载请注明出处。

买车心理学来自w奔波儿霸的雪球原创专栏$长城汽车(02333)$ 汽车作为大件消费，虽然一见倾心很重要，但大部分消费者在一见倾心之后，还是会做比较详细的对比，较少会冲动消费。所以汽车的营销就是尽量让消费者一见倾心，但更重要的是让消费者在详细对比后，仍然能够心甘情愿的掏出钱包。在这里提个问题，H2S比CS35颜值高，做工和质感也更好，技术性能也更强，为什么销量却差很多？H4和CS55相比也是如此。为何长城的车全方面碾压，却卖不过对手？详细对比后，就看出问题所在了。CS35手动档低配6.9万，H2S在拼多多前为8.4万，贵1.5万。H2S各方面全都碾压CS35，贵1.5万，值不值？有人可能觉得值，但更大尺寸的CS55也就卖8.5万。对于这个级别的消费者来说，多花1.5万，是更好的品质重要，还是更大的尺寸重要？显然是尺寸重要。CS55自动档低配卖10万，拼多多前的H4卖11.6万，也是同样的问题。多花1.6万，却仅仅是更好的品质，消费者不买账。H4的价格，可以买更大尺寸的GS4或CS75了，谁会去买H4呢。对于低端消费者来说，同样的价格肯定选更大的尺寸，这是第一定律。小而美是对抗市场规律。哈弗的H2S、H2、H4全都是小而美的定位，被市场无情的教育了。这个其实很好理解。假如一个屌丝，天天吃沙县，有一天心情大好，愿意在吃饭的时候多花10块钱庆祝一下，请问这个屌丝会在吃沙县的时候加个鸡腿，再点瓶啤酒，吃喝的心满意足，还是跑去吃逼格高一点点，但其实肉不多的味千拉面呢？到底是逼格高一点点重要，还是肉多、有啤酒重要？显然是肉多有啤酒重要。再来对比下H8 H9 P8和唐二代这四款车，H9和唐二代是成功的，H8和P8是失败的。原因在哪里？对于愿意花20万以上的价格来买国产车的消费者来说，一定要给他包括他的亲戚朋友一个显而易见的理由，20多万，为什么要买国产，而不是买合资？H8和P8都缺乏显而易见的特点，这俩车的综合素质优秀，但综合素质，无法说服消费者买20多万的国产车。一定得是显而易见的某方面的拔尖才可以。H9和唐二代则都做的比较好。20多万的价格，类似的尺寸，只有H9能带来如此的越野能力和动力性能，合资的竞品都30万以上，自主的竞品只有RX8，越野能力和动力性能都差了一大截。对于唐二代来说，4.5秒加速，100的纯电续航，秒天秒地，这就够了。20万以上的自主汽车，一定要各方面85分以上，某方面达到95分，才能够突围；如果是各方面都90分，缺乏拔尖项，则无法突围作者：w奔波儿霸链接：https://xueqiu.com/4097105650/114029476来源：雪球著作权归作者所有。商业转载请联系作者获得授权，非商业转载请注明出处。

买车心理学来自w奔波儿霸的雪球原创专栏$长城汽车(02333)$ 汽车作为大件消费，虽然一见倾心很重要，但大部分消费者在一见倾心之后，还是会做比较详细的对比，较少会冲动消费。所以汽车的营销就是尽量让消费者一见倾心，但更重要的是让消费者在详细对比后，仍然能够心甘情愿的掏出钱包。在这里提个问题，H2S比CS35颜值高，做工和质感也更好，技术性能也更强，为什么销量却差很多？H4和CS55相比也是如此。为何长城的车全方面碾压，却卖不过对手？详细对比后，就看出问题所在了。CS35手动档低配6.9万，H2S在拼多多前为8.4万，贵1.5万。H2S各方面全都碾压CS35，贵1.5万，值不值？有人可能觉得值，但更大尺寸的CS55也就卖8.5万。对于这个级别的消费者来说，多花1.5万，是更好的品质重要，还是更大的尺寸重要？显然是尺寸重要。CS55自动档低配卖10万，拼多多前的H4卖11.6万，也是同样的问题。多花1.6万，却仅仅是更好的品质，消费者不买账。H4的价格，可以买更大尺寸的GS4或CS75了，谁会去买H4呢。对于低端消费者来说，同样的价格肯定选更大的尺寸，这是第一定律。小而美是对抗市场规律。哈弗的H2S、H2、H4全都是小而美的定位，被市场无情的教育了。这个其实很好理解。假如一个屌丝，天天吃沙县，有一天心情大好，愿意在吃饭的时候多花10块钱庆祝一下，请问这个屌丝会在吃沙县的时候加个鸡腿，再点瓶啤酒，吃喝的心满意足，还是跑去吃逼格高一点点，但其实肉不多的味千拉面呢？到底是逼格高一点点重要，还是肉多、有啤酒重要？显然是肉多有啤酒重要。再来对比下H8 H9 P8和唐二代这四款车，H9和唐二代是成功的，H8和P8是失败的。原因在哪里？对于愿意花20万以上的价格来买国产车的消费者来说，一定要给他包括他的亲戚朋友一个显而易见的理由，20多万，为什么要买国产，而不是买合资？H8和P8都缺乏显而易见的特点，这俩车的综合素质优秀，但综合素质，无法说服消费者买20多万的国产车。一定得是显而易见的某方面的拔尖才可以。H9和唐二代则都做的比较好。20多万的价格，类似的尺寸，只有H9能带来如此的越野能力和动力性能，合资的竞品都30万以上，自主的竞品只有RX8，越野能力和动力性能都差了一大截。对于唐二代来说，4.5秒加速，100的纯电续航，秒天秒地，这就够了。20万以上的自主汽车，一定要各方面85分以上，某方面达到95分，才能够突围；如果是各方面都90分，缺乏拔尖项，则无法突围作者：w奔波儿霸链接：https://xueqiu.com/4097105650/114029476来源：雪球著作权归作者所有。商业转载请联系作者获得授权，非商业转载请注明出处。

Need a quick breath check before your big meeting…or your big date? Well, scientists from South Korea may be able to help. They've engineered a portable device that detects even the tiniest trace of hydrogen sulfide…the stuff that smells like rotten eggs that is one of the primary offenders in oral obnoxiousness. Their work appears in the journal Analytical Chemistry. [Jun-Hwe Cha, et al, Sub-Parts-per-Million Hydrogen Sulfide Colorimetric Sensor: Lead Acetate Anchored Nanofibers toward Halitosis Diagnosis]Bad breath, a.k.a. halitosis, can be more than a social inconvenience. A skunky mouth also may point to some serious underlying medical or dental issues. “Early diagnosis is very significant to prolong your healthy life.”Jun-Hwe Cha of the Korea Advanced Institute of Science and Technology. He says that most of the instruments used for diagnostics are found in clinics or hospitals…which may be tough to get to. And the electronic sensors that are currently used to sniff out various gases require a power source and precise calibration…not easy when you're out and about.“So, we came up with a strategy to develop colorimetric gas sensors, which change its color when detecting biomarker gases.”Think of it as a litmus test for your exhalation. To build their sensor, the researchers took lead acetate…a chemical used in some hair dye products that turns brown when exposed to hydrogen sulfide. And they embedded it in a three-dimensional nanofiber web…so the dye would spread out across a large surface area. That distribution gives the sensor the sensitivity it needs to detect trace amounts of H2S.To test the device, the researchers puffed it with different concentrations of hydrogen sulfide gas. And they found that as little as 400 parts per billion of H2S produced a color change that could be seen by the naked eye. Which is about a fifth as much H2S as you'd need to have stank breath. They even used the device with real human outgassing. The researchers had volunteers blow into a bag. And they spiked these exhalates with 1000 parts per billion H2S. Again, the bad-breathylizer worked like a charm.“This sensor showed high potential for simple halitosis diagnosis with your breath anytime anywhere in a very short time.”The team is now working on similar diagnostic sensors for other vaporous effluvium. It may not sound pretty. But, hey, it's a gas.—Karen Hopkin (The above text is a transcript of this podcast) 

Need a quick breath check before your big meeting…or your big date? Well, scientists from South Korea may be able to help. They've engineered a portable device that detects even the tiniest trace of hydrogen sulfide…the stuff that smells like rotten eggs that is one of the primary offenders in oral obnoxiousness. Their work appears in the journal Analytical Chemistry. [Jun-Hwe Cha, et al, Sub-Parts-per-Million Hydrogen Sulfide Colorimetric Sensor: Lead Acetate Anchored Nanofibers toward Halitosis Diagnosis]Bad breath, a.k.a. halitosis, can be more than a social inconvenience. A skunky mouth also may point to some serious underlying medical or dental issues. “Early diagnosis is very significant to prolong your healthy life.”Jun-Hwe Cha of the Korea Advanced Institute of Science and Technology. He says that most of the instruments used for diagnostics are found in clinics or hospitals…which may be tough to get to. And the electronic sensors that are currently used to sniff out various gases require a power source and precise calibration…not easy when you're out and about.“So, we came up with a strategy to develop colorimetric gas sensors, which change its color when detecting biomarker gases.”Think of it as a litmus test for your exhalation. To build their sensor, the researchers took lead acetate…a chemical used in some hair dye products that turns brown when exposed to hydrogen sulfide. And they embedded it in a three-dimensional nanofiber web…so the dye would spread out across a large surface area. That distribution gives the sensor the sensitivity it needs to detect trace amounts of H2S.To test the device, the researchers puffed it with different concentrations of hydrogen sulfide gas. And they found that as little as 400 parts per billion of H2S produced a color change that could be seen by the naked eye. Which is about a fifth as much H2S as you'd need to have stank breath. They even used the device with real human outgassing. The researchers had volunteers blow into a bag. And they spiked these exhalates with 1000 parts per billion H2S. Again, the bad-breathylizer worked like a charm.“This sensor showed high potential for simple halitosis diagnosis with your breath anytime anywhere in a very short time.”The team is now working on similar diagnostic sensors for other vaporous effluvium. It may not sound pretty. But, hey, it's a gas.—Karen Hopkin (The above text is a transcript of this podcast) 

Uranus pue l'oeuf pourri. Ou si vous préférez, la belle bleue fouette l'odeur acre de nos plus sympathiques geysers ou des plus pénibles boules puantes de nos cancres d'antan. Des astronomes viennent en effet de mesurer la quantité de sulfure d'hydrogène (H2S) présent dans l'atmosphère d'Uranus, et il y en a suffisamment pour que ça ne sente pas la rose, ce qui permet de déduire certains éléments sur la formation de la géante glacée...

Tyler LeBaron - Part 2 of 2 Tyler W. LeBaron is the Founder and Executive Director of the science-based nonprofit Molecular Hydrogen Foundation/Institute. His background is in biochemistry and was a 1-year Adjunct Instructor of Physiology. He Interned at Nagoya University in the department of Neurogenetics to research the molecular mechanisms of hydrogen gas on cell signaling pathways. He is a director of the International Hydrogen Standards Association (IHSA) and the International Molecular Hydrogen Association (IMHA). He speaks at Medical conferences in the US for doctors CMEs/CEUs, and at academic biomedical hydrogen symposia and conferences around the world. He is also a member of the Academic Committee of Taishan Institute for Hydrogen Biomedical Research. He collaborates with researchers at home and abroad, and helps advance the education, research, and awareness of hydrogen as a therapeutic medical gas. Molecular hydrogen (H2) or diatomic hydrogen is a tasteless, odorless, flammable gas. Over 500 peer-reviewed articles demonstrate hydrogen to have therapeutic potential in essentially every organ of the human body and in 150 different human disease models. H2 reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase, etc. H2, like other gaseous signaling molecules (i.e. NO, CO, H2S), appears to have cell signal-modulating activity affording it with anti-inflammatory, anti-obesity, and anti-allergy benefits. Key Molecular Hydrogen Related links mentioned in the podcast: Nature Medicine:https://www.nature.com/articles/nm1577 Hyperbaric hydrogen:https://www.ncbi.nlm.nih.gov/pubmed/1166304 Overview on H2:http://www.molecularhydrogeninstitute.com/hydrogen-an-emerging-medical-gas alkaline water ionizers: http://www.molecularhydrogeninstitute.com/mildly-alkaline-ionized-water-characteristics-benefits-and-future Connect with Tyler here https://www.facebook.com/H2MHF Molecular Hydrogen Related Products. Inhalation:https://www.californiahydrogenwater.com/store/c1/Featured_Products.html Tablets:https://drinkhrw.com/base/home RTD:https://h2bev.com Machines: https://www.trusiih2.com/biohacks Rate, Review, Connect, Inspire Stay updated on new episodes, guest interviews, and health, wellness, and fitness information and resources by subscribing to the HealthCastNow Podcast Show on iTunes. Every day we bring you actionable insight, demystified truth, and simple steps to help you navigate the complex, often confusing health, wellness, and fitness information and answer the questions you’ve been asking Visit HealthCastNow.Com or subscribe on iTunes today!

Tyler LeBaron - Part 1 of 2 Tyler W. LeBaron is the Founder and Executive Director of the science-based nonprofit Molecular Hydrogen Foundation/Institute. His background is in biochemistry and was a 1-year Adjunct Instructor of Physiology. He Interned at Nagoya University in the department of Neurogenetics to research the molecular mechanisms of hydrogen gas on cell signaling pathways. He is a director of the International Hydrogen Standards Association (IHSA) and the International Molecular Hydrogen Association (IMHA). He speaks at Medical conferences in the US for doctors CMEs/CEUs, and at academic biomedical hydrogen symposia and conferences around the world. He is also a member of the Academic Committee of Taishan Institute for Hydrogen Biomedical Research. He collaborates with researchers at home and abroad, and helps advance the education, research, and awareness of hydrogen as a therapeutic medical gas. Molecular hydrogen (H2) or diatomic hydrogen is a tasteless, odorless, flammable gas. Over 500 peer-reviewed articles demonstrate hydrogen to have therapeutic potential in essentially every organ of the human body and in 150 different human disease models. H2 reduces oxidative stress as a selective antioxidant and by maintaining homeostatic levels of glutathione, superoxide dismutase, catalase, etc. H2, like other gaseous signaling molecules (i.e. NO, CO, H2S), appears to have cell signal-modulating activity affording it with anti-inflammatory, anti-obesity, and anti-allergy benefits. Key Molecular Hydrogen Related links mentioned in the podcast: Nature Medicine:https://www.nature.com/articles/nm1577 Hyperbaric hydrogen:https://www.ncbi.nlm.nih.gov/pubmed/1166304 Overview on H2:http://www.molecularhydrogeninstitute.com/hydrogen-an-emerging-medical-gas alkaline water ionizers: http://www.molecularhydrogeninstitute.com/mildly-alkaline-ionized-water-characteristics-benefits-and-future Connect with Tyler here https://www.facebook.com/H2MHF Molecular Hydrogen Related Products. Inhalation:https://www.californiahydrogenwater.com/store/c1/Featured_Products.html Tablets:https://drinkhrw.com/base/home RTD:https://h2bev.com Machines: https://www.trusiih2.com/biohacks Rate, Review, Connect, Inspire Stay updated on new episodes, guest interviews, and health, wellness, and fitness information and resources by subscribing to the HealthCastNow Podcast Show on iTunes. Every day we bring you actionable insight, demystified truth, and simple steps to help you navigate the complex, often confusing health, wellness, and fitness information and answer the questions you’ve been asking Visit HealthCastNow.Com or subscribe on iTunes today!

Find this episode and all episodes at the page for Cider Chat's podcasts. Prevention & Correction of Sulfur-Off Odors in Cider Production was presented by Rebecca deKramer, cider specialist at Scott Laboratories at CiderCon2018. Become an eCiderNews subscriber to download the Power Point Presentation that goes along with this presentation. Click download This chat begins at approximately 9 minutes in. Rebecca presents on the following topics Defining Sulfur-Off Odors Causes of Sulfur-Off Odors Methodologies for preventing Sulfur-Off Odor formation Methodologies for correcting Sulfur-Off Odors What kind of strains of yeast to use Temperature for fermentation How much yeast to use? Chemical Elements impacting cider Sulfur - H2S (hydrogen sulfur) mercaptans from by the break down of certain amino acids if they oxidize, Dimethyl sulfide (DMS) or methylthiomethane is an organosulfur compound with the formula (CH3)2S can be produced. DMS is aromatic and can not easily be removed by copper - Rebekka speaks on the use of copper to remove specific odors The first thing to do for off odor - sulfur aireate the most simplest technique to control off odors? Rack cider off of the gross lees If at the end of fermentation the cider is producing off odors, "simply stirring the gross lees into solution can help." Most common factor contributing to sulfur off odors? the yeast being stressed Rebekka's recommendation - "Have happy yeast. If you have happy yeast, you will have a good fermentation. If you have unhappy yeast they will make your life hell." Orchards that use a sulfur based spray for orchard control. Depending upon the timing of the spray it could leave residual copper on the apple, that can affect the cider. Additional cider and cider yeast considerations The more clarified or concentrated the juice will affect the fermentation as it will have less nutrients for the yeast. Canning cider can make cider suspectible to oxygen as can some screws caps 24:16 - Fermentation Indigenous Fermentations or using wild yeast. Rebekka recommends management via nutrient control, because you do not know what yeast is in the driver seat. "It is a leap of faith" Commercial Pitch - there are numerous options, but make sure to follow the manufacturer's recommendations. If you have no temperature control for fermentation, avoid yeast that require temperature control. Do not under inoculate.  The chances are high that you will have a stressed yeast if you do not follow the manufacturer's recommendations. rehydrate dry yeast before pitching - to nurture a happy yeast environment Treat as soon as you start smelling an off flavor Use the Penny Test for finding H2S. Drop a 1984 or earlier penny into a glass of cider and see if it removes the H2S. will H2s or a mercaptan It responds instantly. If it doesn't respond Rebekka says that the cider is likely in a desulfite form treat with asorbic acid to reduce Make sure it is a penny that is as old as 19 Contact Scott Laboratories Website: http://www.scottlab.com/ email: info@scottlab.com  Telephone: 707- 765-6666 Mentions in this Chat ciderGoingUp Campaign  Ross on Wye Cider and Perry Company John Edwards - Chemical Fingerprints in Cider presented at CiderCon2018 will be posted soon - Stay tuned. John's business: Process and Analytical NMR Services Ask for the following cideries and businesses- By supporting these cidermakers, you in turn help Cider Chat Kurant Cider - Pennsylvania : listen to Joe Getz on episode 14 Big Apple Hard Cider - NYC : listen to Danielle von Scheiner on episode 35 Oliver’s Cider and Perry - Herefordshire/UK ; listen to Tom Oliver on episode 29 Santa Cruz Cider Company - California : listen to Nicole Todd on episode 60 The Cider Project aka EthicCider- California Albermale CiderWorks : listen to Chuck Shelton on episode 56 Cider Summit : listen to Alan Shapiro founder of this cider fest on episode 75. Ramborn Cider Co. Luxembourg. Big Fish Cider Co. Virginia Tanuki Cider Co. Santa Cruz California episode 103 Ross on Wye Cider and Perry, UK Process and Analytical NMR Services - John Edwards provides analytics of cider - stay tuned for his Chemical Fingerprints workshop coming up on Cider Chat Join the #ciderGoingUP Campaign today!  Please Help Support Cider Chat Please donate today. Help keep the chat thriving! Find this episode and all episodes at the page for Cider Chat's podcasts. Listen also at iTunes, Google Play, Stitcher (for Android), iHeartRadio , Spotify and wherever you love to listen to podcasts. Follow on twitter @ciderchat

Enter the Giveaway for 2 tickets to Cider Circus August 26, 2017 at Copper Mountain Ski Resort in Colorado http://cidercircus.com/  Enter by subscribing to eCiderNews and be automatically entered or become a Patron of Cider Chat and be entered automatically to all Cider Chat contests and giveaways. 2 winners are picked on July 1st! Charles McGonegal is full time cider geek who also happens to have a day job as a petro chemist. He and his wife Melissa founded AEppelTreow Winery in Wisconsin in 2001. Why AEppelTreow? Charles says, "I wanted a name that was a little pretentious and not French" Charles has a particular fondness for Perry and has what he calls "the country's (US) only Poire collection (meaning perry pear trees)." He spent years getting permission from the a USDA to plant imported perry pears. "I have what are suppose to be the top three Breton and top three Norman perry pears in a test orchard." In this chat we find out more about AEppelTreow (pronounce Apple True) and get a bushel of tips on making perry. The main chat with Charles begins at 7:48 minutes. The specific chat on Perry begins at 38:20 minutes, with a mini intro by the Talking Pomes. A transcript of this section of the chat on perry making will be transcribed and posted to the Cider Chat Patreon page. Become a patron today and help keep this chat thriving. "Perry is its own thing. It is mostly like making cider. There are a couple of quirks." On storaging of perry during its fermentation and conditioning have a good seal - Charles recommended even using electrical tap never let it (the airlock) dry out CO2 blanket it or use Aragon (because it settles more than CO2) know the Ph of the perry and make the right adjustments Smell every morning during the primary fermentation - when it begins to smell eggy add a 1/4 dose of fermaid  or diammonium phosphate (DAP) Add a 1/4 at a time - helping to clear us the H2S in time   Contact AEppelTreow website: http://aeppeltreow.com/ telephone: (262) 878-5345 email: cider@appletrue.com address: 1072 288th Ave Burlington, WI 53105 Mentions in this Chat Brighton Woods Orchard Shelton Brothers impoters Cider Chat episode 026 Neil Worley on Keeving Cider Chat episode 081 Stephanie & Aaron Carson | Gypsy Circus Cider Co, Tennessee Enter the Giveaway for 2 tickets to Cider Circus August 26, 2017 at Copper Mountain Ski Resort in Colorado http://cidercircus.com/  Enter by subscribing to eCiderNews and be automatically entered or become a Patron of Cider Chat and be entered automatically to all Cider Chat contests and giveaways. 2 winners are picked on Juy 1st! Ask for the following 7 #CiderGoingUP Campaign cider supporters - By supporting these cider makers, you in turn help Ciderville. Kurant Cider - Pennsylvania : listen to Joe Getz on episode 14 Big Apple Hard Cider - NYC : listen to Danielle von Scheiner on episode 35 Oliver’s Cider and Perry - Herefordshire/UK ; listen to Tom Oliver on episode 29 Santa Cruz Cider Company - California : listen to Nicole Todd on episode 60 The Cider Project aka EthicCider- California Albermale CiderWorks : listen to Chuck Shelton on episode 56 Cider Summit : listen to Alan Shapiro founder of this cider fest on episode 75. Please Help Support Cider Chat Please donate today. Help keep the chat thriving! Find this episode and all episodes at the page for Cider Chat's podcasts. Listen also at iTunes, Google Play, Stitcher (for Android), iHeartRadio and where ever you love to listen to podcasts. Follow on twitter @ciderchat    

想了解更多关于哈弗H2s的相关资料，欢迎登陆哈弗SUV官方网站

本期主要内容：别太期待哈弗的双离合变速箱积碳太严重，需要拆卸发动机进行清洗吗？何为合理养车？主要提及车型：奔驰E300L，宝马528，雪铁龙C5，雷诺科雷傲，大众帕萨特，雪佛兰迈锐宝、赛欧3，本田CR-V，三菱欧蓝德，奇瑞艾瑞泽5、艾瑞泽7，哈弗H2S……  

Plus de chapeaux ronds pour les Bretons. Plus de coiffes pour les bigoudènes non plus. D'ailleurs, qu'est-ce que c'est que ce truc avec les bigoudènes ?  Il y a des tas de coiffes en Bretagne. On dirait qu'on ne connait que celle-là. Pourtant, elle vient d'un minuscule bout du bout du sud du Finistère. Et elle cache toutes les autres. Alors bon, ils ont quoi les bretons, s'ils n'ont plus de truc sur la tête ?  Des sabots de bois ? Ca, c'était avant. Une mer froide ? C'est vrai. De la pluie ? Vrai aussi. Des tricots marins et des fruits de mer ? Oui. Des crêpes ? Oui. Des alcooliques ? Oui. Halte. Tout ça, c'est des clichés. C'est vrai, la mer,  c'est pas l'Océan indien. Mais c'est tonique, une eau à 18 degrés dans les bons jours. Non ? Et il ne pleut pas plus qu'à Bordeaux ou à Biarritz. Surtout, on boit autant d'alcool dans d'autres régions. En Bretagne, il y a aussi  de nombreux écrivains, des poètes, des sculpteurs, des musiciens et des comédiens.  Une vraie terre d'artistes. Surtout, l'écologie, la nature et l'environnement sont omniprésents. En octobre 2015, le magazine La Vie classait d'ailleurs les quatre départements bretons dans le top 10 des plus écologiques. Dans l’ordre : les Côtes d’Armor à la troisième place et le Finistère à la sixième. Puis le Morbihan et l’Ille-et-Vilaine (septièmes ex-aequo). Les points forts ? La gestion des déchets. La qualité de l'air. Pour la qualité de l'eau, là, c'est autre chose. Les quatre départements arrivent dans les quarantièmes et soixantièmes places.  Autre point faible ? La protection de la biodiversité. Mais enfin, la vache pie noire est réhabilitée. Il y a un conservatoire de l'abeille noire. On trouve partout des aires marines protégées. Beaucoup d' îlots accueillent les oiseaux migrateurs. Sans oublier les colonies de sternes en baie de Morlaix. Bon. Reste le problème des algues vertes. En 2015, leur volume semblait repartir à la hausse. Un vrai cauchemar pour les estivants. Et pour les stations balnéaires. Si vivantes autrefois, elles sont aujourd'hui désertées. L'algue verte, c'est nocif. Un gaz se forme pendant sa putréfaction : le H2S.  Il est très très dangereux pour l'homme car il bloque la respiration. Si on l'inhale pendant quinze minutes, on peut mourir.  La faute aux nitrates, aux élevages intensifs et à la fertilisation des terres agricoles. Finalement, heureusement qu'il reste les clichés pour se marrer...  

I asked David Aiello, President BioAdvantex Pharma Inc.: of all the molecules, why study and productise N-acetylcysteine? “That makes me think of another question, why did you marry that woman? You become fascinated with something, and your mind sees forward. I saw this as a huge business and scientific project with such a broad scope to help people. We didn't even understand the scope way back then.” Paracetamol-induced acute liver failure. In the US and UK, paracetamol (acetaminophen) toxicity is the most common cause of acute liver failure. When taken in normal therapeutic doses, paracetamol is safe. The cytochrome P450 enzymes convert approximately 5% of paracetamol to a highly reactive intermediary metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). Under normal conditions, NAPQI is detoxified by conjugation with glutathione. In cases of overdose, the pathways become saturated, leading to more NAPQI. Liver supplies of glutathione become depleted, and NAPQI remains in its toxic form in the liver, reacting with cellular membrane molecules, resulting in widespread damage and death of liver cells. Beyond Paracetamol Overdose. Paracetamol is not the only thing that can cause oxidative stress and cell death. Inflammation and oxidative stress are almost synonymous, and we measure both in the testing we do. Urinary P-Hydroxyphenyllactate on an organic acids test is a marker of cell turnover, and 8-Hydroxy-2’-deoxyguanosine (8-OHdG) is a marker of oxidative damage to the guanine of DNA. Enter N-acetylcysteine. The availability of the sulfur-containing amino acid cysteine is known to be the rate-limiting substrate for glutathione resynthesis. L-cysteine is not safe to take as a supplement in high doses, what you want is the N-acetylcysteine (NAC) form. NAC doesn’t encapsulate well because the minimum effective dose is too big to fit into a capsule, and even if it did fit, the molecule would oxidise and fall apart. David's team at BioAdvantex have solved these problems by creating PharmaNAC, a large effervescent tablet sealed into a nitrogen filled blister pack. It's important to understand that exercise is itself an antioxidant and athletes should proceed with caution before supplementing with antioxidants without testing. Context matters. Here’s the outline of this interview with David Aiello 0:00:35    David was trained in immunology at the Stanford Herzenberg Lab. 0:01:03    He wanted to create a product that was relevant, made the right way and given at the right dose. 0:01:34    BioAdvantex have done 12 or 13 clinical trials in breathing, immunity, oxidative stress and mental health. 0:02:46    NAC is the standard of care of acetaminophen toxicity. 0:03:19    80,000 people every year are affected. 0:03:54    NAPQI. 0:04:13    Making glutathione requires glycine, glutamate and cysteine. 0:04:28    Almost every protein is less than 2% cysteine by weight. 0:05:56    You don't want L-cysteine. 0:07:30    NAC is easily oxidised. 0:08:55    Hydrogen sulfide is one of the degradation products of NAC. 0:09:20    Humans can detect H2S at 6 ppb. 0:09:31    There are 7 other degradation pathways. 0:11:43     NAC placebo pills. 0:13:42    Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. 0:15:51    Taking NAC is NOT like pouring water on the fire. 0:18:56    There's about a three-hour gap between when you take cysteine, and when it shows up in your blood, then there's about another three-hour gap until an increase in glutathione. 0:20:07    The liver is main store of cysteine, and also there’s cysteinylglycine in the blood. 0:28:30    Logging food and supplement intake. 0:29:05    Grace Liu. 0:29:10    GAD1 mutation. 0:29:47    The cystine-glutamate antiporter (xCT). 0:35:18    Depression, ruminations and PTSD.

Carl White explains how the gaseous signaling molecule hydrogen sulfide suppresses calcium signaling in adipose tissue macrophages to limit inflammation.

Several studies reported that respiration interacts with olfactory perception. Therefore, in the pilot study of this experiment series human breathing was investigated during an olfactory experiment. Breathing parameters (respiratory minute volume, respiratory amplitude, and breathing rate) were quantified in response to odor stimulation and olfactory imagery. We provide evidence that respiration changed during smelling and during olfactory imagery in comparison to the baseline condition. In conclusion, olfactory perception and olfactory imagery both have an impact on the human respiratory profile, which is hypothesized to be based on a common underlying mechanism named sniffing. Our findings underline that for certain aspects of olfactory research it may be necessary to control and/or monitor respiration during olfactory stimulation. The human ability to localize odors has been investigated in a limited number of studies, but the findings are contradictory. We hypothesized that this was mainly due to differential effects of olfactory and trigeminal stimulation. Only few substances excite selectively the olfactory system. One of them is hydrogen sulphide (H2S). In contrast, most odorants stimulate both olfactory and trigeminal receptors of the nasal mucosa. The main goal of this study was to test the human ability to localize substances, which excite the olfactory system selectively. For this purpose we performed localization experiment using low and high concentrations of the pure odorant H2S, the olfactory-trigeminal substance isoamyl acetate (IAA), and the trigeminal substance carbon dioxide (CO2). In preparation for the localization study a detection experiment was carried out to ensure that subjects perceived the applied stimuli consciously. The aim of the detection study was to quantify the human sensitivity in response to stimulation with H2S, IAA, and CO2. We tested healthy subjects using an event-related experimental design. The olfactory stimulation was performed using an olfactometer. The results showed that humans are able to detect H2S in low concentration (2 ppm) with moderate sensitivity, and possess a high sensitivity in response to stimulation with 8ppm H2S, 50% v/v CO2, and 17.5% v/v IAA. The localization experiment revealed that subjects can localize H2S neither in low nor in high concentrations. In contrast to that, subjects possess an ability to localize both IAA and CO2 stimuli. These results clearly demonstrate that humans are able to localize odorants which excite the trigeminal system, but they are not able to localize odors that stimulate the olfactory system exclusively, in spite of consciously perceiving the stimuli.

Verfärbt sich die Probe während eines in situ Ramanexperimentes, wird die gemessene Ramanintensität stark abgeschwächt. Um einen Intensitätsvergleich zwischen den zu verschiedenen Zeitpunkten erhaltenen Ramanspektren zu ermöglichen, muß daher der Zusammenhang zwischen der Absorption der Proben und der gemessenen Ramanintensität berücksichtigt werden. Für die Abhängigkeit der Ramanintensität ψ∞ und der Reflektivität R der Probe gilt näherungsweise: Ψ∞=ρ I (0 ) s ⋅R ∞(1 R ∞) (1 R ∞)=ρ I (0 ) s ⋅G (R ∞) (= Ramanstreukoeffizient, s= Reflektivitätskonstante, I(0)= Eingestrahlte Lichtintensität) Es wird vorgeschlagen, daß die Reflektivität R der Probe parallel zum in situ Ramanexperiment, z.B. durch Einkoppelung einer Plasmalinie des Lasers, gemessen wird und die Ramanintensität mit Hilfe der Beziehung G (R ∞)=R ∞(1 R ∞) (1 R ∞)korrigiert wird. Die Funktion G(R ) ist hierbei proportional zur beobachteten Ramanintensität. Da der Ramanstreukoeffizient ρ proportional zu ν 4 ist, kann er durch c ⋅ν 4 ersetzt werden. Wird die Frequenzabhängigkeit von R berücksichtigt, so gibt die Funktion Ψ ∞die Abhängigkeit des Ramanstrahlungsflusses von der verwendeten Erregerfrequenz an: Ψ∞(ν)=c ν 4 I (0 ) s ⋅R ∞(ν)(1 R ∞(ν)) (1 R ∞(ν))=c I (0 ) s ⋅G (R ∞(ν))⋅ν 4 R (ν)kann direkt aus dem UV-vis-Spektrum der Probe erhalten werden. Das Maximum der Funktion Ψ∞(ν)zeigt die erwartete optimale Laserfrequenz an. Zu hohe Laserleistung kann zur Veränderungen der Probe innerhalb des Laserspots führen. Um Artefakte zu vermeiden, sollte die optimale Laserleistung durch Vergleich mehrerer in situ Ramanexperimente bei verschiedenen Laserleistungen ermittelt werden. Zirkondioxid-Proben neigen zu erhöhtem Untergrund in den Ramanspektren. Die physikalischen Ursachen dafür sind weitgehend ungeklärt, es könnte sich aber um einen Streuprozess handeln, der mit dem Hydratisierungsgrad der Probe zu tun hat. Um erhöhten Untergrund zu vermeiden, sollten diese Proben vor jedem Ramanexperiment bei Temperaturen zwischen 673 und 773 K in trockenem Sauerstoff vorbehandelt werden. Die Charakterisierung durch DTA-TG, Ramanspektroskopie, UV-vis, TPR und FTIR am unpromotierten WO3/ZrO2-Katalysator (WZ) bestätigt die in der Literatur beschriebenen Strukturmodelle 9,11,96,103 . . Die Wolframphase liegt nicht als kristallines Wolframtrioxid, sondern als amorphe Oberflächenwolframate vor, wobei die Wolframatome weitgehend verzerrt oktaedrisch koordiniert und über W—O—W-Brücken untereinander verknüpft sind. Diese Spezies sind über W—O—Zr-Brücken mit dem tetragonalen Zirkondioxid-Träger verbunden. W=O-Gruppen kommen ebenfalls vor und sättigen möglicherweise die Valenzen an den Rändern der Oberflächenwolframate. Hochtemperatur-FTIR-Spektroskopie zeigt, daß trotz Dehydratisierung in trockenem Sauerstoff bei 573 K molekulares Wasser auf dem Katalysator verbleibt. ESR-Spektroskopie an der oxidierten WZ-Probe zeigt, abgesehen von Fe 3+ -Verunreinigungen, die im Zirkondioxid-Träger lokalisiert sind, keinerlei paramagnetische Spezies. ESR-Spektroskopie und UV-vis-Spektroskopie zeigen, daß unter Reaktions-temperaturen (> 473 K) durch die Wechselwirkung mit Wasserstoff die WZ-Probe reduziert wird, wobei W 5+ -Zentren entstehen. Es können mehrere W 5+ -Zentren unterschieden werden, wobei ein O2-Adsorptionsexperiment nahelegt, daß zum einen koordinativ ungesättigte oberflächennahe W 5+ -Zentren und zum anderen tiefergelegene W 5+ -Zentren entstehen. Mit steigender Reduktionstemperatur werden zunehmend tiefergelegene W 5+ -Zentren reduziert. In weit geringerem Maße entstehen bei der Reduktion auch Zr 3+ -Zentren. Ramanspektroskopie am mit Wasserstoff reduzierten Katalysator zeigt keine nennenswerten Veränderungen, da bei den verwendeten Reduktionstemperaturen nur eine partielle Reduktion eintritt. FTIR-Spektroskopie am mit Wasserstoff bzw. Deuterium reduzierten Katalysator zeigt die Entstehung von neuen OH- bzw. OD-Gruppen. Tieftemperatur-CO-Adsorption läßt darauf schließen, daß die durch die Reduktion gebildeten OH-Gruppen weniger azide sind als die OH-Gruppen, die vor der Reduktion vorhanden sind. Insgesamt läßt sich sagen, daß die in der Literatur postulierte Bildung von W 5+ -Zentren 11,13,103,116,117 und OH-Gruppen 11,13,103,116,117,118 durch die Wechselwirkung mit Wasserstoff voll bestätigt werden kann. WZ besitzt Aktivität für die Isomerisierung von n-Pentan zu Isopentan, wobei aber neben Isopentan zahlreiche gesättigte und ungesättigte Crack-Produkte entstehen. Es wird der typische, bereits in vorhergehenden Arbeiten beschriebene Aktivitätsverlauf beobachtet. Nach einer Induktionsperiode und einem Aktivitätsmaximum kommt es zur Des-aktivierung und Stabilisierung auf niedrigem Aktivitätsniveau. Die Produktverteilung spricht weder für einen Haag-Dessau-Cracking-Mechanismus noch für einen monomolekularen oder bimolekularen Mechanismus. Eine mögliche Erklärung für das konstante Verhältnis der Entstehungsraten der Nebenprodukte zum Hauptprodukt Isopentan wäre, daß alle Produkte aus der gleichen höhermolekularen Zwischenstufe entstehen und somit alle Produkte über den gleichen Reaktionsweg (Reaktionsweg A) gebildet werden. Dieser Reaktionsweg steht wahrscheinlich mit höhermolekularen organischen Ablagerungen in Zusammenhang, bei denen es sich möglicherweise um Polyalkenyl-Spezies handelt. Die unpromotierte WZ-Probe zeigt Aktivität für die Hydrierung von Propen. Nach dem Prinzip der mikroskopischen Reversibiltät erscheint eine Aktivierung der Alkane durch Dehydrierung an den Wolframaten möglich, wobei das W 5+ /W 6+ -Redoxsystem ausgenutzt wird. Das Zusammenlagern der Alken-Zwischenstufen führt möglicherweise zu den höhermolekularen organischen Ablagerungen, deren langsame Bildung eine Erklärung für die Induktionsperiode wäre. Die Zugabe von Wasserstoff in den Produktstrom führt zu einer Zunahme der Selektivität für Isopentan. Dies ist wahrscheinlich auf die zusätzliche Ermöglichung eines monomolekularen Reaktionsweges (Reaktionsweg B) zurückzuführen. Dieser mono-molekulare Reaktionsweg wird durch die Reduktion der Wolframate durch Wasserstoff im Eduktstrom ermöglicht und führt zur effektiveren Desorption der Alken-Zwischen-stufen. Diese zeigen wegen der verringerten Lebensdauer / Konzentration eine geringere Tendenz, sich zu höhermolekularen Ablagerungen zusammenzuschließen. Es wird vorgeschlagen, daß bei diesem monomolekularen Reaktionsweg B die Desorption über die Hydrierung des verzweigten Alkens an den Wolframaten, d.h. über den umgekehrten Weg der Aktivierung des linearen Alkans (Dehydrierung), geschieht. Vorreduktion führt zu niedrigerer Aktivität und höherer Selektivität. Es wird keine Induktionsperiode der Gesamtaktivität beobachtet. Bei niedrigen Laufzeiten dominiert wahrscheinlich der monomolekulare Mechanismus (Reaktionsweg B). Der Einfluß des für die Induktionsperiode verantwortlichen Reaktionsweg A ist zu gering, als daß sich die Induktionsperiode auf die Gesamtaktivität auswirken würde. in situ UV-vis-Spektroskopie zeigt, neben starker Verfärbung des Katalysators, Banden organischer Ablagerungen (405, 432, 613 nm), die mit zunehmender Laufzeit stärker werden. Es handelt sich wahrscheinlich um Polyalkenylkationen, die mit dem Reaktionsweg A in Zusammenhang stehen. Die Kettenlänge der Polyalkenylkationen scheint sich mit zunehmender Laufzeit zu vergrößern. in situ Ramanspektroskopie zeigt die Bildung prägraphitischer Ablagerungen. Zunehmende Laufzeit, die Zugabe von Wasserstoff in den Produktstrom sowie Vorreduktion des Katalysators haben keinerlei Einfluß auf die Art der Ablagerungen. Es kann keinerlei Zusammenhang zwischen der beobachteten Aktivität / Selektivität und der Bildung der prägraphitischen Teilchen beobachtet werden. Die beobachteten prägraphitischen Teilchen stehen mit der Isomerisierungsreaktion nicht in Zusammenhang, sondern sind ein Nebenprodukt. Sie tragen möglicherweise, aber nicht ausschließlich, zur Desaktivierung des Katalysators bei. in situ ESR-Spektroskopie zeigt die Bildung von organischen Radikalen sowie von oberflächennahen W 5+ -Zentren nach der Reaktion mit n-Pentan. Die Bildung von organischen Radikalen ist möglicherweise ein Hinweis auf eine schrittweise Oxidation zum Alken. Möglicherweise sind die beobachteten Radikale aber auch auf höhermolekulare, ungesättigte organische Ablagerungen zurückzuführen. Der mit Platin promotierte Katalysator PtWZ wird durch die Wechselwirkung mit Wasserstoff erheblich leichter reduziert. Analog zu der unpromotierten Probe führt die Reduktion der Wolframate zu W 5+ -Zentren und OH-Gruppen. ESR-Spektroskopie zeigt, daß alle bei 673 K reduzierbaren Zentren auch bei Raumtemperatur reduziert werden. Tieftemperatur CO-Adsorption läßt darauf schließen, daß die durch die Reduktion gebildeten OH-Gruppen weniger azide sind als die OH-Gruppen, die vor der Reduktion vorhanden sind. Die Effekte sind darauf zurückzuführen, daß Pt die Reduktion mit Wasserstoff katalysiert, wobei der Wasserstoff dissoziativ auf der Platinoberfläche adsorbiert wird und auf die Wolframate übertritt („Spillover“). Die in der Literatur postulierte erleichterte Reduktion der Wolframate durch Wasserstoff bei der An-wesenheit von Platin unter Bildung von W 5+ -Zentren 11,13,103,116,117 und OH-Gruppen 11,13,103,116,117,118 kann bestätigt werden. PtWZ zeigt bei der Isomerisierung von n-Pentan ohne Wasserstoff eine leicht erhöhte Aktivität gegenüber der unpromotierten Probe WZ. Das verstärkte Auftreten von Alkenen wird auf Nebenreaktionen an den durch das Alkan partiell reduzierten PtOx-Partikeln zurückgeführt (Reaktionsweg C). Die Zugabe von Wasserstoff in den Produktstrom bei der Isomerisierung von n-Pentan an PtWZ führt zu einer ca. 60 mal höheren Aktivität im Vergleich zur maximalen Aktivität von WZ sowie zu Selektivitäten für Isopentan von ca. 95%. Erhöhte Aktivität und Selektivität werden auf das hauptsächliche Vorliegen des selektiv und schnell ablaufenden monomolekularen Reaktionsweges (Reaktionsweg B) zurückgeführt. Die Nebenprodukte entstehen wahrscheinlich durch Hydrogenolyse des n-Pentans an den Platinpartikeln (Reaktionsweg D). Vorreduktion führt zur maximalen Aktivität und Selektivität zu Anfang der Reaktion. Das Experiment bestätigt, daß die Rolle des zugegebenen Wasserstoffs nicht nur in der Reduktion der PtOx-Partikel zu metallischem Platin besteht, sondern daß Wasserstoff eine aktive Rolle bei der Isomerisierung spielt. Durch den Verlust des im System gespeicherten Wasserstoffes werden die Reaktionswege B und D, die an PtWZ in Anwesenheit von Wasserstoff ablaufen, durch die Reaktionswege A und C abgelöst, die an PtWZ in Abwesenheit von Wasserstoff ablaufen. Eisenpromotierung erschwert generell die Reduktion durch Wasserstoff. Die Wolframate der mit Eisen promotierten FeWZ-Katalysatoren (FeWZ(N) und FeWZ(S)) können erst bei einer Reduktionstemperatur von 673 K unter Ausbildung von W 5+ -reduziert werden. Bei einsetzender Reduktion der Wolframate werden die Eisen(III)-Zentren zu niedrigeren Oxidationsstufen reduziert. Es konnten keine Unterschiede im Reduktionsverhalten zwischen der FeWZ(N) und der FeWZ(S)-Probe festgestellt werden. PtFeWZ-Katalysatoren (PtFeWZ(N) und PtFeWZ(S)) werden im Gegensatz zu dem PtWZ-Katalysator bei Raumtemperatur nur in geringem Maße reduziert. Im Gegensatz zu PtWZ, wo bereits bei Raumtemperatur die maximale Intensität des W 5+ -Signals zu beobachten ist, vergrößert sich das Signal mit steigender Reduktionstemperatur. Mit steigender Reduktionstemperatur wird zunehmend Fe 3+ zu niedrigeren Oxidationstufen reduziert. Die erschwerte Reduktion ist wahrscheinlich auf einen kinetischen Effekt zurückzuführen, wobei die Eisenpromotierung einen der Platinpromotierung entgegen-gesetzten Effekt hat und die Reduktion der Wolframate kinetisch hemmt. FeWZ(N) ist unter den gegebenen Reaktionsbedingungen mit oder ohne Zugabe von Wasserstoff nahezu inaktiv. Die beiden PtFeWZ-Proben zeigen ohne Zugabe von Wasserstoff ebenfalls nur geringe Aktivität. Produktverteilung und Aktivitätsverlauf ähneln den bei PtWZ beobachteten. Eisen hat nur einen positiven Effekt auf die Isomeriserung von n-Pentan, wenn sowohl Platin vorhanden ist als auch Wasserstoff in den Produktstrom hinzugegeben wird. Sind diese Bedingungen erfüllt, verbessert Eisenpromotierung die Selektivität der PtFeWZ-Proben. Im Fall der Isomerisierung an PtFeWZ(S) kann zusätzlich zur verbesserten Selektivität eine deutlich erhöhte Aktivität beobachtet werden. Da die Nebenprodukte, die zur Erniedrigung der Selektivität führen, wahrscheinlich durch Hydrogenolyse des n-Pentans auf den Platinpartikeln (Reaktionsweg D) entstehen, wird die Erhöhung der Selektivität gegenüber n-Pentan durch den Einfluß der Eisenpromotierung auf die Platin-partikel erklärt. Möglicherweise hat die Eisenpromotierung Einfluß auf die Dispersion des Platins, oder es bilden sich Fe/Pt-Legierungen bzw. -Verbindungen aus. Die erhöhte Aktivität der PtFeWZ(S)-Probe wird auf einen kooperativen Effekt zwischen den Wolframaten und SO4 2- -Spezies zurückgeführt, die nach der Synthese möglicherweise auf der Oberfläche des PtFeWZ(S)-Katalysators vorhanden sind. Ramanspektroskopie an SZ zeigt den typischen tetragonalen Träger sowie zwei verschiedene Sulfat-Spezies. Zeitabhängige in situ Ramanspektroskopie an SZ während der Isomeriserung von n-Pentan zeigt, daß im Laufe der Reaktion eine dieser Spezies verschwindet. Dies wird auf Reduktion zu H2S durch das eingesetzte Alkan zurückgeführt. Gleichzeitig wird der für diese Proben typische Aktivitätsverlauf (Induktionsperiode, rasche Desaktivierung) beobachtet. Im Gegensatz zu Berichten in der Literatur kann keine Bande bei 1600 cm -1 beobachtet werden, die in dieser Arbeit auf prägraphitische Teilchen zurückgeführt wurde. Geht man davon aus, daß die Isomerisierung an SZ ähnlich wie an WZ abläuft, bestätigt dies, daß es sich bei diesen Spezies um ein Nebenprodukt handelt, das nicht direkt mit der Isomerisierungsreaktion zu tun hat.

Endogenous and maximum respiration rates of nine purple sulfur bacterial strains were determined. Endogenous rates were below 10 nmol O2 · (mg protein · min)-1 for sulfur-free cells and 15–35 nmol O2 · (mg protein · min)-1 for cells containg intracellular sulfur globules. With sulfide as electron-donating substrate respiration rates were considerably higher than with thiosulfate. Maximum respiration rates of Thiocystis violacea 2711 and Thiorhodovibrio winogradskyi SSP1 (254.8 and 264.2 nmol O2 · (mg protein · min)-1, respectively) are similar to those of aerobic bacteria. Biphasic respiration curves were obtained for sulfur-free cells of Thiocystis violacea 2711 and Chromatium vinosum 2811. In Thiocystis violacea the rapid and incomplete oxidation of thiosulfate was five times faster than the oxidation of stored sulfur. A high affinity of the respiratoty system for oxygen (K m =0.3–0.9 M O2, V max=260 nmol O2 · (mg protein · min)-1 with sulfide as substrate, K m =0.6–2.4 M O2, V max=14–40 nmol O2 · (mg protein · min)-1 with thiosulfate as substrate), for sulfide (K m =0.47 M, V max=650 nmol H2S · (mg protein × min)-1, and for thiosulfate (K m =5–6 M, V max =24–72 nmol S2O 3 2- · (mg protein · min)-1 was obtained for different strains. Respiration of Thiocystis violacea was inhibited by very low concentrations of NaCN (K i =1.7 M) while CO concentrations of up to 300 M were not inhibitory. The capacity for chemotrophic growth of six species was studied in continuous culture at oxygen concentrations of 11 to 67 M. Thiocystis violacea 2711, Amoebobacter roseus 6611, Thiocapsa roseopersicina 6311 and Thiorhodovibrio winogradskyi SSP1 were able to grow chemotrophically with thiosulfate/acetate or sulfide/acetate. Chromatium vinosum 2811 and Amoebobacter purpureus ML1 failed to grow under these conditions. During shift from phototrophic to chemotrophic conditions intracellular sulfur and carbohydrate accumulated transiently inside the cells. During chemotrophic growth bacteriochlorophyll a was below the detection limit.

Die Verbindungen (π-C5H5)(CO)2LM-X (L = CO, PR3; M = Mo, W; X = BF4, PF6, AsF6, SbF6) reagieren mit H2S, p-MeC6H4SH, Ph2S und Ph2SO(L′) zu den ionischen Komplexen [(π-C5H5)(CO)2LML′]+ X−. Auch Schwefel-verbrückte Komplexe, [(π-C5H5)(CO)3W---SH---W(CO)3(π-C5H5)]+ AsF6− und [(π-C5H5(CO)3M-μ-S2C=NCH2Ph-M(CO)3(π-C5H5)], wurden erhalten. Reaktionen mit SO2 und CS2 wurden untersucht.