Podcasts about epac

Ce samedi, Gilles Wenger nous emmène à Saxon à lʹoccasion des portes ouvertes de lʹEPAC, première école de BD et Game Art / Dev en Suisse. Il sera accompagné dʹune étudiante de 3ème année, ainsi que de Quentin Rahm, chargé de communication et enseignant en classe préparatoire (Peinture, Infographie, Graphisme), et de M. Frédéric Catogni, président de lʹécole. www.epac.ch

In this episode, we chat with Reji Woods, an actor, director, and producer making his EPAC directorial debut. With a career spanning Broadway, Off-Broadway, national tours, and international stages, Reji has also appeared in TV shows like Orange Is the New Black and The Marvelous Mrs. Maisel, and films like Tapawingo. He's the co-founder of Bending Threads Cabaret Company and founder of Reji Woods Productions. Alongside his performing career, Reji teaches voice and acting in Lancaster County and serves as Theatre Director at Ephrata High School. Tune in to hear more about his creative journey and upcoming projects!

In this episode, we explore the vibrant world of the Ephrata Performing Arts Center (EPAC), a nonprofit community-based theater dedicated to providing quality cultural and educational programming. Joining us is Edward R. Fernandez, the Artistic Director, who shares insights on EPAC's mission to make diverse theater arts accessible and meaningful for all audiences. We discuss the exciting $2.4 million renovations that have transformed EPAC into a year-round venue, allowing for a wide variety of live plays, musicals, workshops, and community events. Edward also highlights how EPAC is redefining its legacy by showcasing future stars on stage. As one patron beautifully stated, “It may not be Broadway, but you sure can see it from here.” Tune in for an inspiring conversation about the arts and community!

Greetings & welcome back to the podcast. This episode we are joined by Tristan Goodman - President of The Explorers and Producers Association of Canada (EPAC), a national lobby group representing Canada's top oil and gas entrepreneurs. EPAC represents over 140 member companies, who spend billions of dollars annually  across Canada - directly employing more than 50,000 people in every province and territory.Mr. Goodman is a leading advocate for the Canadian energy industry with governments, regulators, the news media and general public. Mr.Goodman was Senior Vice President with one of Canada's largest energy regulators and has worked for a several multinational energy companies. Mr. Goodman holds a Ph.D.(University of Calgary), LL.M.(University of London) & LL.B.(Osgoode Law School). Among other things we discussed Provincial vs. Federal Jurisdiction, Attracting Investment Capital & What Makes Good Energy PolicyEnjoy.Thank you to our sponsors.Without their support this episode would not be possible:Connate Water SolutionsCanada ActionEnverusContango MarketingCanadian Gas AssociationUpgrade LabsSupport the show

In a harmonious collaboration that promises to captivate audiences, EPAC (Ephrata Performing Arts Center) proudly announces its partnership with THEM the Collective for a special two-night event. This unique concert is poised to be an immersive celebration of music, seamlessly blending entertainment and education in a way that only the synergy of these two artistic powerhouses can achieve. The upcoming event marks a continuation of the successful collaboration between EPAC and THEM the Collective, underscoring their shared commitment to providing Lancaster County with extraordinary musical experiences. As a cultural beacon in the region, EPAC is thrilled to join forces once again with THEM the Collective, a group known for pushing boundaries and fostering a dynamic musical landscape. Audiences can anticipate a showcase of immense talent, featuring a diverse array of musicians and vocalists. The roster not only boasts some of Lancaster's finest, many of whom are seasoned EPAC veterans, but also showcases remarkable artists from across the northeast. The stage will come alive with performers hailing from iconic cities like Philadelphia, New York City, and Baltimore, creating a melting pot of musical influences and styles. This convergence promises to deliver a musical journey that transcends geographical boundaries, uniting performers and audience members alike in the shared joy of live performance. As EPAC and THEM the Collective prepare to unfold this musical extravaganza, Lancaster County residents are in for a treat, experiencing the magic that can only arise when artistic brilliance converges in a celebration of sound. Evolution of Black MusicSupport WITF: https://www.witf.org/support/give-now/See omnystudio.com/listener for privacy information.

ROMA (ITALPRESS) - "La nostra associazione da 23 anni aiuta tutti coloro che si rivolgono a noi sull'epatite e sulle malattie del fegato". Lo ha detto Ivan Gardini, presidente dell'Associazione EpAC Onlus, a margine dell'evento promosso da Ace, Alleanza per le Epatiti. "Lo screening è fondamentale perché se vogliamo ripulire l'Italia da questa infezione che peraltro è trasmissibile - ha aggiunto - bisogna assolutamente continuare con questo screening e anzi rafforzarlo con più risorse e allargando la fascia della popolazione generale a cui viene offerto e arrivare fino in fondo per raggiungere il target fissato dall'Oms: eliminare il virus Hcv".xl3/xc3/fsc/gsl

07-01-23Support the show: https://www.loveneverfailsus.com/donateSee omnystudio.com/listener for privacy information.

Arrancamos con nuestra experiencia en Amsterdam, donde pudimos probar la Yamaha Booster, una bici eléctrica inspirada en una moto. Sí, así es. Una bici que además tiene una versión ebike EPAC (lo que llamaríamos una “ebike normal”) y una opción Speed Pedelec. Esta última, “corta” la asistencia a los 45 km/h y tiene un motor con una potencia de 500W. La bici es una propuesta diferente y original y su presentación oficial una oportunidad para probar en un mismo día dos tipos de ebike. Como suele ocurrir, una buena forma de romper prejuicios. De las calles de Amsterdam, a las bajadas más radicales. Y es que la Giant Glory, leyenda de las bicis de DH, lanza su versión 2023. La Glory es la muestra del interés de una marca por estar en todos los segmentos posibles del ciclismo. Y, por otro lado, la constatación de que el nuestro es uno de los pocos deportes en los que puedes ir a la tienda y comprar una máquina de competición. Ni Márquez ni Alonso pueden hacer eso. Volvemos a las ebikes para ver la versión especial que ha hecho Mondraker de su Crafty Carbon. Pocas veces nos gustaría ver una Öhlins de otro color que no sea su característico negro y dorado. Pues esta es una de ellas. Y terminamos con otro componente exclusivo cómo es el conjunto de manillar y potencia integrados Roval Rapide. Este episodio ha sido patrocinado por Shimano y hemos decidido destacar la tecnología de la aplicación E-Tube Project. Tienes toda la información sobre ella en: https://bike.shimano.com/es-ES/e-tube/project.html

 Choosing your product packaging is one of the most important decisions you'll make in starting your company, but it often gets rushed over. Your packaging impacts your shelf-life, branding, manufacturing method, and more. Join me for a conversation with Jeff Jacobs with ePac as we discuss what you need to consider when choosing packaging for your brand. Startup to Scale is a podcast by Foodbevy, an online community to connect emerging food, beverage, and CPG founders to great resources and partners to grow their business. Visit us at Foodbevy.com to learn about becoming a member or an industry partner today.

In this episode, Geri Greenall, CFO of Spartan Delta Corp. and EPAC board member, shares her insights on how the energy industry can showcase its positive impact on communities. Geri is leading an initiative to encourage energy companies to partner with Classroom Champions and provide financial support to drive positive change in the rural classrooms where energy workers live and raise their families. By forming local partnerships, the energy industry proactively addresses negative perceptions and demonstrates its commitment to sustainable development and community well-being. The Energize Communities campaign aims to shape a more positive narrative around the industry's efforts to give back to the communities they serve. Explore Geri's leadership and the industry's efforts to promote sustainable development and community well-being through local partnerships and education initiatives.Proactivity beats out reactivity every time - whether in shaping the narrative of an entire industry or getting ahead of trauma to ensure all kids are set up for future success. While these two topics might seem unrelated, Geri helps you understand how big players in the energy sector are putting millions of dollars into contributing to local communities. If you're curious about storytelling, public relations and impacting your business or industry, this episode is a must-listen!

Mary Jo Swearingen has a personal directive to connect people to their career goals. She found a way to do this by serving on the Emerging Professional Advisory Council or EPAC for SHRM. Mary Jo is an emerging progressional who helps other emerging professionals. Listen to episode 75 to learn more about what Mary Jo is up to from Nashville, Tennesse. LBMC, Employment Partners Middle Tennessee State University SHRM EPAC University of Tennessee State of Tennessee SHRM-CP Tennessee Comptroller of the Treasury SHRM MAC Outlast The Power of Habit Silent Patient  

01-28-23Support the show: https://www.loveneverfailsus.com/donateSee omnystudio.com/listener for privacy information.

Director Carmen Caldera-Brozska and cast member Brennan Price talk about the upcoming performance of It’s a Wonderful Life at the Elizabethtown Performing Arts Center.  December…

We talk yogurt, building through social media, guy health and innovation in packaging.

In this episode, industry insiders Wayne Robinson and Lindy Hughson dissect the big stories, issues and trends emerging in ANZ print over the month of November.We discuss controversies surrounding multi-employer bargaining streams, reflect on the highlights from our recent Print21+PKN Packaging News LIVE event which focused on digitally printed packaging, and we review how the Supreme Court ruling against Vic Forests may impact print. We wrap up by covering the month's Melbourne mergers, ePac's launch of its cloud system, and the continued increases in postal costs.LINKS:Multi-Employer Bargaining: PVCA says NO to 'Rough as Guts' IR billwww.print21.com.au/industry/industry/multi-employer-bargaining-pvca-says-no-to-rough-as-guts-ir-billDigitally Printed Packaging on song at LIVEwww.print21.com.au/packaging/digitally-printed-packaging-on-song-at-live Precision buys Manark in growth drive, gets 10-Colour B1www.print21.com.au/commercial/precision-buys-manark-in-growth-drive-gets-10-colour-b1-----------------------------The Print Files Podcast is produced by Southern Skies Media on behalf of Print21, owned and published by Yaffa Media (www.print21.com.au).The views of the people featured on this podcast do not necessarily represent the views of Print21, Yaffa Media, or the guest's employer. The contents are copyright by Yaffa Media.If you wish to use any of this podcast's audio, please contact Print21 via their website www.print21.com.au or send an email to editor@print21.com.auHost: Wayne RobinsonCoordinator: Grant McHerronProducer: Steve VisscherEditor: Chris VisscherPrint21 - © 2022

In this episode Wayne Robinson and Lindy Hughson review yet another busy month in print. We discuss the exciting news of Kelly Northwood's new role as CEO of PVCA, and what the priorities for the newly merged association will be. We assess the new government's first budget, and its impact on print. Print sectors under analysis this month include digitally printed packaging, with the news of ePac's record breaking order for Indigo presses, and we discuss the upcoming PKN+Print21 Amplify and Engage event, slated for 9 November in Melbourne, which will focus on the opportunities for brands and for print businesses in digitally printed packaging, The duo then discuss the return of outdoor media, following the pandemic, along with the rise of new applications including mesh printing, and how the public response to unfettered asset deployment, particularly in cities, may impact its success. And on challenges for the industry, we note the closing of several print businesses, and the unstable sector of newspaper printing.Article Links:Print21 + PKN Live: www.print21.com.au/liveKELLIE NORTHWOOD BECOMES CEO OF PVCAwww.print21.com.au/industry/industry/kellie-northwood-becomes-ceo-of-pvcaNINE BACKFLIPS ON AXING TASSIE PAPERSwww.print21.com.au/industry/industry/nine-backflips-on-axing-tassie-papersMIKE JONES' CDM PRINT HITS THE SKIDSwww.print21.com.au/commercial/mike-jones-cdm-print-hits-the-skidsALL OVER FOR PRINT DUOwww.print21.com.au/commercial/all-over-for-print-duo------------------------------The Print Files Podcast is produced by Southern Skies Media on behalf of Print21, owned and published by Yaffa Media (www.print21.com.au).The views of the people featured on this podcast do not necessarily represent the views of Print21, Yaffa Media, or the guest's employer. The contents are copyright by Yaffa Media.If you wish to use any of this podcast's audio, please contact Print21 via their website www.print21.com.au or send an email to editor@print21.com.auHost: Wayne RobinsonCoordinator: Grant McHerronEditor: Chris VisscherProducer: Steve VisscherPrint21 - © 2022

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.19.512717v1?rss=1 Authors: Harvey, K. E., Tang, S., LaVigne, E. K., Pratt, E. P. S., Hockerman, G. H. Abstract: The ER Ca2+ channel ryanodine receptor 2 (RyR2) is required for maintenance of insulin content and glucose-stimulated insulin secretion, in part, via regulation of the protein IRBIT in the insulinoma cell line INS-1. Here, we examined store-operated and depolarization-dependent Ca2+entry using INS-1 cells in which either RyR2 or IRBIT were deleted. Store-operated Ca2+ entry (SOCE) stimulated with thapsigargin was reduced in RyR2KO cells compared to controls, but was unchanged in IRBITKO cells. STIM1 protein levels were not different between the three cell lines. Basal and stimulated (500 M carbachol) phospholipase C (PLC) activity was also reduced specifically in RyR2KO cells. Insulin secretion stimulated by tolbutamide was reduced in RyR2KO and IRBITKO cells compared to controls, but was potentiated by an EPAC-selective cAMP analog in all three cell lines. Cellular PIP2 levels were increased and cortical f-actin levels were reduced in RyR2KO cells compared to controls. Whole-cell Cav channel current density was increased by 65% in RyR2KO cells compared to controls, and barium current was reduced by acute activation of the lipid phosphatase pseudojanin preferentially in RyR2KO cells over control INS-1 cells. Action potentials stimulated by 18 mM glucose were more frequent in RyR2KO cells compared to controls, and insensitive to the SK channel inhibitor apamin. Taken together, these results suggest that RyR2 plays a critical role in regulating PLC activity and PIP2 levels via regulation of SOCE. RyR2 also regulates {beta}-cell electrical activity by controlling Cav current density, via regulation of PIP2 levels, and SK channel activation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Good evening and Welcome to another episode of #sportsbizmusic the podcast and I got the chance to sit down and chat with Pro Basketball player Jaylen Nixon. On this show we talked about his life and growing up in Va. We also talked about his basketball Career, his top 5 and more!!!  Check out his highlights: Professional Experience: (Philadelphia JBA) Junior Basketball Association JBA 2018 JBA ALL Star 25ppg 5reb 55% fg  JBA Career highlights: https://youtu.be/_Xv456U-Nr0 Game: https://m.facebook.com/story.php?story_fbid=939360559579692&id=855005588015190  https://m.facebook.com/story.php?story_fbid=945839732265108&id=855005588015190  2020 Spain Showcase 15ppg 5reb 45% 3pt  https://www.instagram.com/tv/CSjzP8bIndV/?igshid=YmMyMTA2M2Y=  https://www.instagram.com/p/CTC0vKHljAW/?igshid=YmMyMTA2M2Y=  2022 Miami Pro League #10  14ppg 4reb  https://youtu.be/oBk1bu1V21A  https://www.instagram.com/tv/Cg2ZZWjJpcg/?igshid=YmMyMTA2M2Y=   2022 Danny rumph classic  1x rumph classic champion 15 ppg 6 reb  Full game: https://youtu.be/duLYniaIv_4 Highlights: Jaylen Nixon  DOB: 12/22/1997 Age: 24years old Passport Ready: Yes  Position: 1/2 Guard Height: 6'3” Weight:175lbs  College Experience: Community College of Philadelphia   18.5 ppg 5.2 reb 54.6% fg 44.1% 3pt   https://www.njcaa.org/sports/mbkb/2017-18/div3/players/jaylennixonaqwb  Career high: 33pts 12reb   https://www.nccspartans.com/news/2017/12/12/mens-basketball-philadelphia-wins-battle-of-nationally-ranked-teams.aspx?path=mbball  Accolades: NJCAA player of the year Conference player of the year 1st team all region 1st team all conference EPAC  https://www.ccp.edu › news › newsColonials Head into the Playoffs as Conference Champs https://www.instagram.com/tv/ChM4DCSl5Mu/?igshid=YmMyMTA2M2Y=  Articles: https://www.cityofbasketballlove.com › ...Rumph Classic: Late bloomer Jaylen Nixon continues to chase pro dreams

In this episode, Food & Drink Business editor Kim Berry is joined by the ANZ managing director for ePac Flexibles, Jason Brown, and RED Group's marketing and communications manager, Rebecca Gleghorn.We get an insight into how ePac provides innovative flexible packaging solutions and the role RED Group plays in recycling soft plastics in Australia. We explore the importance and benefits of soft plastics, dispel misconceptions on plastic packaging and recycling, and discuss advancements in the sector.LINKS: APCO National Packaging Targets by 2025:www.foodanddrinkbusiness.com.au/news/apco-launches-anzpac-2025-targets-roadmapePac: www.epacflexibles.com.auRed Group: www.redcycle.net.auPackaging Recyclability Evaluation Portal (PREP tool): www.prep.org.au/------------------------------The Food & Drink Business Podcast is produced by Southern Skies Media on behalf of Food & Drink Business, owned and published by Yaffa Media (www.foodanddrinkbusiness.com.au).The views of the people featured on this podcast do not necessarily represent the views of Food & Drink Business, Yaffa Media, or the guest's employer. The contents are copyright by Yaffa Media.If you wish to use any of this podcast's audio, please contact Food & Drink Business via their website www.foodanddrinkbusiness.com.au or send an email to editor@foodanddrinkbusiness.com.auHost: Kim BerryMC: Grant McHerronEditor: Chris VisscherProducer: Steve VisscherFood & Drink Business - © 2022

In this episode Wayne Robinson and Lindy Hughson review a very busy month in print, as the financial results for the big players came in. Packaging was the key theme of August, we analyse the big moves by IVE, Amcor, ePac and Opal, and discuss what it means for the rest of the print industry, as the sector becomes increasingly attractive. As the government mandates a 43 per cent reduction in emission levels we look what steps different print businesses are taking to get there, including one planting a forest to offset its emissions, and another covering its roof in solar panels for its energy. Article Links: ACCC, IVE & Ovato deal www.print21.com.au/commercial/accc-races-flat-out-for-ive-ovato-deal IVE and packaging www.print21.com.au/commercial/packaging-beckons-for-ive Opal investing in new carton plant www.print21.com.au/packaging/opal-invests-140m-in-new-carton-plant Spicers on journey to carbon neutrality www.print21.com.au/commercial/spicers-embarks-on-journey-to-carbon-neutrality ------------------------------ The Print Files Podcast is produced by Southern Skies Media on behalf of Print21, owned and published by Yaffa Media (www.print21.com.au). The views of the people featured on this podcast do not necessarily represent the views of Print21, Yaffa Media, or the guest's employer. The contents are copyright by Yaffa Media. If you wish to use any of this podcast's audio, please contact Print21 via their website www.print21.com.au or send an email to editor@print21.com.au Host: Wayne Robinson Coordinator: Grant McHerron Producer: Steve Visscher Print21 - © 2022

In this session: Sukhdev Singh Saini (Colgate-Palmolive), Shane Tansey (FUJIFILM Integrated Inkjet Solutions) and Lucas Gouvea Silva (SIG Combibloc) After the success of last year's world's first Global Connected Packaging event, we are happy to share this year's Connected Packaging Summit 2022. You have been able to listen to technology, innovation, packaging, and sustainability experts as they discussed and shared insights on how all of these fields are being integrated in order to produce unique and exclusive customer experiences, gamification, loyalty programs, delivering stunning results to the most prominent players in the industry. Joining us were experts from AB InBev, Tetra Pak, Colgate, Elopak, FUJIFILM, Avery Dennison, Scantrust, Epac, SIG Combibloc, Greiner Packaging, Transcend Packaging, GoStraw, Schoeller Allibert and Garcia-Carrion. On the first day, we discussed innovative packaging. On the second day, we focused on sustainable solutions and digital transformation. Visit our website to know more about us and our services: https://www.appetitecreative.com/

In this session: Neil Hay (Avery Dennison) and Tony Fazhev (Avery Dennison) After the success of last year's world's first Global Connected Packaging event, we are happy to share this year's Connected Packaging Summit 2022. You have been able to listen to technology, innovation, packaging, and sustainability experts as they discussed and shared insights on how all of these fields are being integrated in order to produce unique and exclusive customer experiences, gamification, loyalty programs, delivering stunning results to the most prominent players in the industry. Joining us were experts from AB InBev, Tetra Pak, Colgate, Elopak, FUJIFILM, Avery Dennison, Scantrust, Epac, SIG Combibloc, Greiner Packaging, Transcend Packaging, GoStraw, Schoeller Allibert, and Garcia-Carrion. On the first day, we discussed innovative packaging. On the second day, we focused on sustainable solutions and digital transformation. Visit our website to know more about us and our services: https://www.appetitecreative.com/

In this session: Nathan J. Anderson (Scantrust) and Johnny Hobeika (Epac Flexible Packaging) After the success of last year's world's first Global Connected Packaging event, we are happy to share this year's Connected Packaging Summit 2022. You have been able to listen to technology, innovation, packaging, and sustainability experts as they discussed and shared insights on how all of these fields are being integrated in order to produce unique and exclusive customer experiences, gamification, loyalty programs, delivering stunning results to the most prominent players in the industry. Joining us were experts from AB InBev, Tetra Pak, Colgate, Elopak, FUJIFILM, Avery Dennison, Scantrust, Epac, SIG Combibloc, Greiner Packaging, Transcend Packaging, GoStraw, Schoeller Allibert, and Garcia-Carrion. On the first day, we discussed innovative packaging. On the second day, we focused on sustainable solutions and digital transformation. Visit our website to know more about us and our services: https://www.appetitecreative.com/

In this session: Sharon Kawinzi - Operational Marketing Manager at Tetra Pak Eastern Africa After the success of last year's world's first Global Connected Packaging event, we are happy to share this year's Connected Packaging Summit 2022. You have been able to listen to technology, innovation, packaging, and sustainability experts as they discussed and shared insights on how all of these fields are being integrated in order to produce unique and exclusive customer experiences, gamification, loyalty programs, delivering stunning results to the most prominent players in the industry. Joining us were experts from AB InBev, Tetra Pak, Colgate, Elopak, FUJIFILM, Avery Dennison, Scantrust, Epac, SIG Combibloc, Greiner Packaging, Transcend Packaging, GoStraw, Schoeller Allibert, and Garcia-Carrion. On the first day, we discussed innovative packaging. On the second day, we focused on sustainable solutions and digital transformation. Visit our website to know more about us and our services: https://www.appetitecreative.com/

In this session: Rachel Sheldon (Greiner Packaging) After the success of last year's world's first Global Connected Packaging event, we are happy to share this year's Connected Packaging Summit 2022. You have been able to listen to technology, innovation, packaging, and sustainability experts as they discussed and shared insights on how all of these fields are being integrated in order to produce unique and exclusive customer experiences, gamification, loyalty programs, delivering stunning results to the most prominent players in the industry. Joining us were experts from AB InBev, Tetra Pak, Colgate, Elopak, FUJIFILM, Avery Dennison, Scantrust, Epac, SIG Combibloc, Greiner Packaging, Transcend Packaging, GoStraw, Schoeller Allibert and Garcia-Carrion. On the first day, we discussed innovative packaging. On the second day, we focused on sustainable solutions and digital transformation. Visit our website to know more about us and our services: https://www.appetitecreative.com/

In this session: Carmen Barrero Perez (AB Inbev) and Julie De Bruyckere (Schoeller Allibert) After the success of last year's world's first Global Connected Packaging event, we are happy to share this year's Connected Packaging Summit 2022. You have been able to listen to technology, innovation, packaging, and sustainability experts as they discussed and shared insights on how all of these fields are being integrated in order to produce unique and exclusive customer experiences, gamification, loyalty programs, delivering stunning results to the most prominent players in the industry. Joining us were experts from AB InBev, Tetra Pak, Colgate, Elopak, FUJIFILM, Avery Dennison, Scantrust, Epac, SIG Combibloc, Greiner Packaging, Transcend Packaging, GoStraw, Schoeller Allibert and Garcia-Carrion. On the first day, we discussed innovative packaging. On the second day, we focused on sustainable solutions and digital transformation. Visit our website to know more about us and our services: https://www.appetitecreative.com/

In this session: Andrijana Golubovic (Elopak) and Alejandro Martin (Garcia-Carrion) After the success of last year's world's first Global Connected Packaging event, we are happy to share this year's Connected Packaging Summit 2022. You have been able to listen to technology, innovation, packaging, and sustainability experts as they discussed and shared insights on how all of these fields are being integrated in order to produce unique and exclusive customer experiences, gamification, loyalty programs, delivering stunning results to the most prominent players in the industry. Joining us were experts from AB InBev, Tetra Pak, Colgate, Elopak, FUJIFILM, Avery Dennison, Scantrust, Epac, SIG Combibloc, Greiner Packaging, Transcend Packaging, GoStraw, Schoeller Allibert, and Garcia-Carrion. On the first day, we discussed innovative packaging. On the second day, we focused on sustainable solutions and digital transformation. Visit our website to know more about us and our services: https://www.appetitecreative.com/

In this session: Matthew Ward (Transcend Packaging Ltd.), Cloé Morel (Tetra Pak France) and Gabor Vass (GoStraw Ltd) After the success of last year's world's first Global Connected Packaging event, we are happy to share this year's Connected Packaging Summit 2022. You have been able to listen to technology, innovation, packaging, and sustainability experts as they discussed and shared insights on how all of these fields are being integrated in order to produce unique and exclusive customer experiences, gamification, loyalty programs, delivering stunning results to the most prominent players in the industry. Joining us were experts from AB InBev, Tetra Pak, Colgate, Elopak, FUJIFILM, Avery Dennison, Scantrust, Epac, SIG Combibloc, Greiner Packaging, Transcend Packaging, GoStraw, Schoeller Allibert and Garcia-Carrion. On the first day, we discussed innovative packaging. On the second day, we focused on sustainable solutions and digital transformation. Visit our website to know more about us and our services: https://www.appetitecreative.com/

Super excited to announce new guest, Alyssa Crook, to The Story!Alyssa got her start in the EPAC Kids for Kids production "The Jungle Book" as Kaa the Snake at the age of 8, so you could say she caught the bug early. She grew up performing on the stages of EPAC, Rainbow Dinner Theatre, American Music Theatre, and the Dutch Apple. Recently graduated from Muhlenberg College with a double major in Theatre and English, Alyssa is currently working the season in the new Entertainment Department at the Strasburg Railroad in various roles, including that of the company's Fight Captain. You can find Alyssa and her work here: Instagram : @_alyssacrook_Website : AlyssaCrookTalent.comSupport this podcast at — https://redcircle.com/the-story/donations

Super excited to announce new guest, Alyssa Crook, to The Story!Alyssa got her start in the EPAC Kids for Kids production "The Jungle Book" as Kaa the Snake at the age of 8, so you could say she caught the bug early. She grew up performing on the stages of EPAC, Rainbow Dinner Theatre, American Music Theatre, and the Dutch Apple. Recently graduated from Muhlenberg College with a double major in Theatre and English, Alyssa is currently working the season in the new Entertainment Department at the Strasburg Railroad in various roles, including that of the company's Fight Captain.You can find Alyssa and her work here:Instagram : @_alyssacrook_Website : AlyssaCrookTalent.comSupport this podcast at — https://redcircle.com/the-story/donations

No es algo generalizado, pero ocurre. A veces incluso nos llega algún mensaje preguntando ¿cómo puedo deslimitar mi ebike? En este vídeo os vamos contar lo que les respondemos. Te vamos a explicar las consecuencias reales de deslimitar o trucar tu ebike: 1.- La multa La multa… Sí. Deslimitar una bike te puede ocasionar una multa de la Guardia Civil o de la Policia Local de tu municipio. Pero no por el hecho de deslimitarla a nivel técnico. Sino porque al deslimitar, conviertes tu ebike en un ciclomotor. Una ebike estaría dentro de la categoría EPAC. Eso supone tener: • Asistencia al pedaleo por un motor eléctrico auxiliar hasta una potencia nominal máxima continua de 250W, sólo y exclusivamente siempre que se pedalee. • Asistencia al pedaleo hasta 25km/h. Esto está regulado por reglamento europeo e incluido en el Reglamento General de Vehículos y en el Reglamenteo General de Circulación. Si deslimitas la ebike pasa a ser el equivalente a un ciclomotor. Y necesita por tanto, matriculación, seguro e ITV… Y si no llevas todo eso: - Por ir sin seguro: Multa de entre 600 y 3000€ y el depósito o precinto del vehículo. El dinero depende del vehículo, si está circulando, reiteración… - Por ir sin ITV: 200€ Y si encima se da el caso de que no tienes el carnet de conducir… pues podrías hasta ser detenido. En fin, que puedes acabar con infracciones administrativas e incluso penales. En fin, no es fácil que un agente te ponga todo el pack… Pero algo te llevas seguro. 2.- Adiós garantía. He visto pisapapeles de 5.000€. Como os lo digo. Bicis trucadas que llegan al fabricante, éste detecta la trampa y… no hay garantía. La marca de la bici y del motor no van a mirar más. Si detectan que la bici ha sido deslimitada en algún momento, se acabó. Y no vale con volver a limitarla. Hemos consultado con varias marcas esta semana y nos confirman que la deslimitación queda en el software y se detecta. Y, además, también pueden hacerlo mediante el análisis de otros parámetros. Si el problema afecta a motor y batería, el coste total de la jugada puede ser de más de entre 2000 y 3000€. 3.- ¿Y quién la truca? En 2020 AMBE y CONEBI avisaron sobre lo obvio. Que tiendas y talleres que deslimitan o trucan ebikes también pueden tener responsabilidad. Porque, a fin de cuentas, si alguien tiene un accidente grave con una ebike, su familia, su seguro o incluso el mismo podrían buscar “responsables” y “culpables”. Y ahí la tienda o el taller podría estar incurriendo y cito “en la incitación a una infracción administrativa”. Es decir, que pueden acabar comiéndose un marrón interesante. Preparando este guión, he hablado con un par de servicios técnicos del sector y me han asegurado que ya han recibido peticiones de informes por parte de aseguradoras en casos de accidente. 4.- Una vida más corta… No la tuya. Pero sí la de tu bici. En una bici deslimitada el motor sufre más y la batería dura mucho menos. Y no nos referimos a autonomía. Solo en cargas tendrá más y, por tanto, tendrá menos vida útil. Y además, sufre más por el tipo de uso. 5.- El fin de las ebikes Es uno de los mayores riesgos para el fin de las ebikes. Es la excusa perfecta que están buscando muchos gestores u otros colectivos para quitarnos de en medio: no son bicis, son motos; son unos piratas, son un peligro…

We're heading east on this month's episode to interview three advocates, each representing a local climbing organization in Pennsylvania: Kate Fetterolf with Eastern Pennsylvania Alliance of Climbers, Ryan Shipp with South Central Pennsylvania Climbers, and Joel Brady with Southwestern Pennsylvania Climbers Coalition. Kate, Ryan, and Joel shared their perspective on what's happening in their respective region of the state and also weren't shy boasting about how great the climbing is in Pennsylvania. Pennsylvania is rich with a wide variety of climbing opportunities. Perhaps it's mostly known for its world-class bouldering but opportunities abound to sport and trad climb as well. Each organization does a great job addressing needs and any issues in their area and have been incredibly supportive of each other. Whether it's working through forming a new LCO, access, or closures, they can depend on each other to be a supporting network. Follow along to hear the latest on climbing advocacy in Pennsylvania. 6:20- Kate's intro 8:30- Ryan's intro 11:23- Joel's intro 15:52- Kate & the Eastern PA Alliance of Climbers (EPAC) 22:34- Being in close proximity to major metro areas 29:59- Engaging with a diverse group of climbers 33:53- EPAC's 2022 agenda 36:45- Aldo Leopold ethos 38:24- Ryan & the South Central PA Climbers (SCPC) 46:08- SCPC's major areas and projects 58:27- SCPC's ambassador program 1:00:54- JEDI resources 1:02:10- Joel & the Southwestern PA Climbers Coalition (SWPACC) 1:13:37- Working with the PA Gaming Commission 1:18:01- Partnering with indoor facilities 1:13:30- Recommendations for how other regional LCOs can collaborate Eastern PA Alliance of Climbers: https://epaclimbers.org/ South Central PA Climbers: https://www.scpclimbers.org/ Southwestern PA Climbers Coalition: https://www.swpacc.org/

Music courtesy of "Irregular BlueGrass trio", used with permission, recorded live via iPhone at 1st Presbyterian Church Nashville, Tennessee. See today's avatar.I discovered something interesting on Sunday morning viewing desert. A weather program on FNB — that's Fox News Business Problema/Sp it's only one hour and it's early to boot 7 AM CDT but it's worth setting your recorder to watch later instead of those endless Sunday talking heads.  Back in “the day” one wag asserted the only thing which changed was the host & the backdrop and the movable desk with a new avatar.  Instead of an endless recycle of him-a-canes & her-a-canes I propose something more catchy. For our western shore EPAC - 05 / 14 — 01 for our eastern shore, it would be WATLA 05/14 – 01-22

Wayne Robinson, editor of Print21, and Lindy Hughson, publisher of Print21 and PKN Packaging News, bring us a review and analysis of the major developments, issues and trends emerging in the ANZ print industry during May.This month's edition was recorded at the Auspack trade show in Melbourne, which had a big focus on sustainable printing this year. We discuss Detpak's innovation to enable its clients to move from plastic to fibre-based packaging, as well as developments from other packaging printers including Opal and Zipform.The sustainability theme this month continues as we celebrate the outdoor Innovator of the Year award winner, Nigel Spicer, of Cactus Imaging, for the new Smart Skin billboard media.We also discuss the ins and outs of Trimatt receiving the APPMA's Excellence of Australian Manufacturing Award for its Cardline 7000 system.Excitingly, we discuss the first new printing plant to have opened in Australia for several years, ePac. The shortage of skilled workers, an issue exacerbated by the recent removal of print apprenticeships from the Australian Apprenticeships government priority list, is also highlighted.Following this we explore the launch of Heidelberg's cloud-based Prinect Direct, which is helping to automate both production and administration, and will ultimately lead to print buyers effectively inputting all the data for the job, with the workflow scheduling the job.Finally we look at the impact the Ukrainian war has had on their print industry and what can be done to support the companies and their staff.------------------------------The Print Files Podcast is produced by Southern Skies Media on behalf of Print21, owned and published by Yaffa Media.The views of the people featured on this podcast do not necessarily represent the views of Print21, Yaffa Media, or the guest's employer. The contents are copyright by Yaffa Media.If you wish to use any of this podcast's audio, please contact Print21 via their website www.print21.com.au or send an email to editor@print21.com.auHost: Wayne RobinsonCoordinator: Grant McHerronProducer: Steve VisscherPrint21 - © 2022

Transcription:00:03Welcome to changing the rules, a weekly podcast about people who are living their best lives, and advice on how you can achieve that too.  Join us with your lively host Ray Lowe, better known as the luckiest guy in the world.Ray Loewe00:17Well, this is the lively host, Ray Lowe, and welcome to our brand new studio in Willow Street, Pennsylvania, wherever that might be. And we've got a great guest today. But before we get into our guest, I want to remind everybody that changing the rules is about the fact that all through our lives we're given rules, we're given them by our parents, and then we went to school in the school gave us rules in the church gave us rules, and our jobs gave us rules. And I think it was Steve Jobs, the Apple guy who came back and said, You know, when you're living your life under somebody else's rules, you're not living your life, you're living somebody else's life. And we're lucky enough that every week we interview one of the luckiest people in the world. Now we have a definition for that. The luckiest people in the world are those people who take control of their own lives and live them under their own terms. And we certainly have one of the luckiest people in the world with us today. And I want to start out with a statement and you're gonna see why it's so important as we go through. You know, just because you reach a certain age in life doesn't mean that you have to retire and that you're washed up. And in fact, many people when they reach a certain age are useful. And sometimes they're outstanding, and sometimes they're even become the best there is regardless of their age. So I want to do is introduce today, Candice O'Donnell. You prefer Candice or Candy?Candace O'Donnell  01:45Candice? Candice. I think Candy sounds like a retired stripper at my age.Ray Loewe01:53Oh, well,Candace O'Donnell  01:55I go with Candace,Ray Loewe01:56you know, you'd probably do that well, too. But we'll get into that one. Okay, so So Candice has a really interesting career. And her background is she's raised four children. Okay, not a small feat. While she was doing that she taught English at Elizabethtown University, she has always been active in the theater. And then she got to a point where she had a chance to create some projects that were of interest to her. Okay, and a let's and that started later in life. So So let's, let's tell everybody how young you are.Candace O'Donnell 02:31I'll be at in about a month 27th two months 27 of JuneRay Loewe02:37And you know, many people, when they reach these certain ages, say it's time to shut down? Well, not Candice. Okay, so tell us a little bit about these projects that you created. And tell us about them in general. And then let's get specific about the three specific ones that you chose to put into life.Candace O'Donnell 02:56Well, as you said, I've been doing theater here in Lancaster for maybe 25 years. I've done the Fulton I've done EPAC, my favorite role until I started doing this. This one-woman show was Driving Miss Daisy. That's a wonderful play with a fabulous message. But I guess it was about six, seven years ago. I started doing these one-woman shows I had done small skits for the anniversary of the Fulton 200 and 50th anniversary of people who had appeared at the phone, one of them being Sarah Bernhardt. And so I started I had done a little bit on Carrie Nation, the Temperance leader I had done Abigail Adams, but I started going in earnest into these one-woman shows. I had always wanted to do Mary Lincoln. And I hesitated on Mary Lincoln because it was such a tragic life. She was mentally ill, and she lost every single person that she loved. Every single person that she loved was taken away from her. And I couldn't figure out a way to get into humor in it. And so I kept hesitating, because I thought can I put in audiences through 70 minutes, 75 minutes of hell, her life was hell. And then I remembered one of her funny lines. When she first met Lincoln. She was the belle of the ball and he was a country bumpkin. And he came up to her and he said, Ms. Todd, I want to dance with you in the worst kind of way. And then she said, and then he proceeded to do exactly that. So that's where I got a little humor and I developed that. And then I decided to undertake Sarah Bernhardt an entirely different person. I go for a through-line with each of my characters. The through-line for Mary Lincoln was much madness is divinest sense, which is Emily Dickinson. And was it the track it was a fact that she was mentally ill. Sarah Bernhardt entirely different story, my throughline for her was Edsp ofs. Riojan was not ago not at all. And Sarah Bernhardt lived life on her own terms. She was a survivor. She invented the casting couch. She invented the PR agent. And she invented the cougar. She was amoral, rather than immoral. She was a tremendous survivor. She continued to perform 10 years after her leg was amputated. And incidentally, she did perform at the Fulton Theatre in Lancaster. And finally, I worked my way to Queen Victoria. I had had a strong interest in her for years. And the subtitle there is he was my all in all, Victoria is about her obsession, obsession with her husband, Albert. And particularly funny because they had nine children, she hated babies. You do the math, you put it together? Why did they have nine children? She hated them. So that's how I got into these. And I've really enjoyed them.Ray Loewe06:03Okay, well, I'm sorry, you don't have any passion for any of these at all. But you know, I think what does it take to do this? So let's go back to the first one to Mary Todd Lincoln. First of all, you had to make the decision that this was a character that you were going to bring to life. Okay. And so what did you have to do? I mean, because you wrote the script, right?Candace O'Donnell  06:29You I, it takes me about two to three years to research each person. And, but it's, it's amazing. Ray, the, the through-line comes to you almost instantly, at least it did to me when you see what the glue of this character is what you're going to emphasize. Now, another writer might not emphasize it. But then your research all falls into place. AndRay Loewe06:56okay, so you write the script, you're starting two years ahead of before you're going to deliver this Right, correct. And you got to go where do you find the background data on these people?Candace O'Donnell  07:07There, you're gonna really be surprised at this. It shows you what a low-tech dinosaur I am. I get it out of books. You've heard of books, B. O. O. K. S. I do not get online. Most people today would do their research online.Ray Loewe07:23Yeah. You know, we have our engineer here, who is college age, you know, and I think he's a digital book guy. Oh, is he? okay. Well, maybe not. Maybe he knows what a book is. Okay, You read books in college? Yeah, he did. Okay, so you dig in, and you've got two years of finding a character? Have you ever started on any and then found out halfway through that you couldn't get enough material and you killed the character?Candace O'Donnell 07:48No, I'm a little bit too cautious a person for that? I wouldn't. I'm usually interested in the character and know something about the character. And also I use films and plays as my sources too. I know enough about the character that I have yet to launch into one and thought, oh, no, this is actually a boring character. In fact, the more I researched them, the more fascinating they become.Ray Loewe08:13Okay, so So you start digging into this and you got this two-year process and you're writing your own script? Yeah. Okay. Which probably helps you memorize the script. Okay, and now you're going to deliver this. Okay, so how do you deliver this do you need to get sponsors for this as something that you go to somebody and do a trial.Candace O'Donnell  08:38I'm really glad you asked me that question, because it gives me a chance to pay tribute to Betsy Hurley of the Lancaster Literary Guild, and I haven't been asked that question before. She's the person who got me into the Ware Center with Mary Lincoln. Okay, and once those were very successful, and then I didn't have trouble getting into the Ware center after that. Most of them the more sellouts. My difficulty was COVID. You know, I had a delay of several well, all told this production was delayed four years because of COVID.Ray Loewe09:16Okay, so this is why Candice is one of the luckiest people in the world. I want you to think about this as our listeners here. Okay, so she took on a project several years ago, she knew it was going to take several years to do this. She ran into the COVID barrier most other people use as an excuse to quit, but not here. We were going to deliver this and we're gonna get into a couple of other things later as we go. So all of a sudden, Mary Todd Lincoln appeared on the stage, and you have a script. And do you have any plans to do anything with that script? Now that you've given the character life?Candace O'Donnell  09:55You mean Mary Todd Lincoln? Yeah. I've been asked to do a program here at Willow Valley and what I sometimes do with my programs, I'll do 20 minutes of Mary Lincoln. I'll do 20 minutes of Sarah Bernhardt. I'll do 20 minutes of Queen Victoria. I'm developing that now.Ray Loewe10:14Okay, so you've finished, Mary Todd. She's now alive. Okay. Yes. And now you sat there and you said, Okay, what's next? You didn't stop. Right? So how did you get the drive to go on to the next one? Candace O'Donnell 10:34I, because I'm an incorrigible ham. That's what my husband would tell you. Okay, that's where I get the drive. Okay, I have to admit it.Ray Loewe10:42Well, this is where the passion meets the excellence, though, so go ahead.Candace O'Donnell 10:47Well, that's what motivates me. But also, right, I really get passionate about these women. That's why I don't choose anybody that I don't admire. I see their foibles. We all have our foibles. But I couldn't do it fair, if I were doing man, I couldn't do Trump because I wouldn't, I couldn't admire him enough to do him, okay, I admire all these women. And the more I know about them, the more I see the hell they went through in various ways, and they triumphed over it. So it's not at all hard to motivate myself to do this. It was hard to keep the faith during COVID. With all the delays, like um, and of course, as you and I discussed, I'm getting older. So I'm wondering if I'm gonna go into dementia. Oh, and by the way, I'm losing my balance. I take the balance classes here at Willow Valley. So I won't fall down on stage. Okay. So you're wondering, you are wondering, is the body is the mind going to fail me. And you just sort of leap out in faith,Ray Loewe12:00but you didn't give up? And it worked.  So let's talk about being queen. Okay. So I met you when you were going into this role of Queen of the empire Victoria. Okay. And, to tell you the truth, when I met you, I went to your performance with some trepidation. I mean, I'm sitting there saying, you know, can I sit through an hour plus of this? And I'll tell you, I was wrapped for 75 minutes, I don't think I moved in my seat, and to your little heart and to get me to do that. This is not me. I you know, so you know, you're an athlete. So you did something special here. And, it was a wonderful performance, and you brought this character to life. And I could just see in your eyes and your, the way you moved on stage that you are not you that don't you are Queen, Victoria. Okay. So let's talk a little bit about putting this one together. Because you had to start two years ago, you'd already done a couple of these. So you knew you could do it. Yeah. But now you started asking these questions in one of the things that you told me was about two weeks before you were gonna give this guess what, what happened?Candace O'Donnell 13:12Really, really nasty cough? And, of course, immediately tested for COVID. No, it wasn't COVID chest X-ray, is it pneumonia. And that was frightening I, people, I don't get frightened by performing because as I already confessed, I'm a ham I love to perform. But this cough frightened me. Because I was really terrified that I would not be able to deliver the performance. I was thinking of some other actresses I've worked with, but that was too late for them to memorize a 70-minute script. And I remember my daughter, saying, Mom, well, you may just have to give up on this. And she said I said, Well, I'm, you know me. I'm not giving up at this point. Don't you know my personality? And she said, Well, would you rather die mom? And I said yes. Yes. I would rather die than have to call Keegan my granddaughter was in the show introducing it. She's a temple, a student at Temple called Keegan and say, Keegan, we're not doing it. I would. So that was our big family joke. Mom would rather die than not do it so. As you know, you were there. Well, I was coughing right before I went out, I had to sucrets, I had tea. But now this, you said I'm the luckiest person in the world. And you are and I am and we are but that this was also a blessing. Because I absolutely believe this was God. I mean, I go out there and I'm not coughing. It's unbelievable to me, nor did I fall down on stage. Ray Loewe14:39And the show must go on. The show must go on. So I think this is a message that I want our listeners to get across. Most of us during our lives, put off projects that we want to do because life gets in the way. You know, here you were. You're raising four kids. You're teaching English. You know you're doing all of these things and then somewhere along the line, I think this germ woke up in your head and said, this has been there for a long time I have to do this.Candace O'Donnell  15:09Yeah. It's, it's, I think, if you have a particular passion, you almost have it from the womb.Ray Loewe15:17And it's never too late to do that. And even at your stage of the game, when you are worried about health issues and things like that, guess what? You know everything falls in place, it was no problem. You got it done.Candice O'Donnell  15:32I was flabbergasted by it myself. Oh, I want to say one other thing, because there were so many Willow Valley people in the audience, I had two very sharp audiences, you being one of the members of the audience, who were completely with me, and you can tell that when you step out on stage, you can feel the button. You know, Bruce Springsteen, performing as an exchange of energy between the audience and the performer. You can tell when they're with you, they were laughing ahead of my jokes. That before I got to my punch line, they were laughing. I thought, Oh, boy.Ray Loewe16:10Well, you know, what was the gift? Well, when we had to stand up and sing God, save the queen, and do the royal wave to greet you in there. I mean, you had us at the beginning. But I think this is a really good lesson for people because here you are. And I'm going to predict you're going to do another one. I have no idea what it might be.Candace O'Donnell  16:30My husband will kill me but yeah, we can all see I'm incorrigible.Ray Loewe16:33And the other thing that you're doing here is you're creating scripts, that maybe somebody else will do not as well as you do, but they'll do it at some point in time. And, and the research that you've done is just phenomenal projects. And I think you're to be congratulated for doing that. And I think it just makes you younger and younger and younger. So there all right, it keeps you going forward. Okay, so, unfortunately, we're near the end of our time here. So it's flies. Do you have any, any parting comments, any words of wisdom to anybody who wants to do these things? Or anything for the good of mankind?Candace O'Donnell  17:12Well, I just want to say I am hoping to eventually sell the scripts so that they will live on after me. Again, you may think I sound like a religious fanatic here. If you can get the guts to get out there and do it. Something in my case, I believe it was God, but something will see you through. Don't be afraid to try.Ray Loewe17:39And with that, I don't think there's anything more to say. So Luke is our engineer here at Willow Valley. So Luke, sign us off, please.17:52Thank you for listening to changing the rules. Join us next week for more conversation, our special guest and to hear more from the luckiest guy in the world.

Wayne Robinson, editor of Print21, and Lindy Hughson, publisher of Print21 and PKN Packaging News, bring us a review and analysis of the major developments, issues and trends emerging in the ANZ print industry during April.We start this month's episode by reviewing the intended merger of the two biggest associations in the print industry, TMRC and PVCA, which is good news for the industry.The discussion then moves on to the shock closure of Ovato Heatset New Zealand, and the paper supply issues which impacted them, and what that means for the rest of the industry.Next up is the Media Super and Cbus super fund merger, looking at what it means for printer sin the fund, and for the industry as a whole. Following this we look into the outdoor and display sector, which seems to be returning with force, following a dip during the Covid pandemic, and the labelling sector that rode a strong wave during Covid and is now offering opportunities to all.We wrap up the episode with the news of ePac's expansion less than six months after opening its business in Melbourne, and finish examining the exciting return of trade shows in Australia and overseas. It appears the suppliers have the appetite to attend, now to see if print business owners and managers have the same ambition.------------------------------The Print Files Podcast is produced by Southern Skies Media on behalf of Print21, owned and published by Yaffa Media.The views of the people featured on this podcast do not necessarily represent the views of Print21, Yaffa Media, or the guest's employer. The contents are copyright by Yaffa Media.If you wish to use any of this podcast's audio, please contact Print21 via their website www.print21.com.au or send an email to editor@print21.com.auHost: Wayne RobinsonCoordinator: Grant McHerronEditor: Chris VisscherProducer: Steve VisscherPrint21 - © 2022

El 21 de enero de 2022 se ha publicado en el BOE el Manual de características de los vehículos de movilidad personal (VMP) o patinetes eléctricos. La DGT, más de un año después, por fin publica la información técnica que tiene que tener un VMP o patinete eléctrico para poder circular. Los actuales patinetes eléctricos pueden circular hasta enero de 2027 tal y como están, sin garantías técnicas. Los patinetes eléctricos (VMP) que se vendan a partir de enero de 2024 deberán tener cumplir con el manual de características de los vehículos de movilidad personal publicado en el BOE como resolución de la DGT. https://www.boe.es/diario_boe/txt.php?id=BOE-A-2022-987 El Manual de características de los vehículos de movilidad personal. Lo que tiene que cumplir los patinetes eléctricos llega con mucho retraso y demasiados años para entrar en vigor realmente. ¿Qué es un vehículo de movilidad personal? Sección 1. Definición de Vehículo de movilidad personal (VMP) Vehículo de una o más ruedas dotado de una única plaza y propulsado exclusivamente por motores eléctricos(1) que pueden proporcionar al vehículo una velocidad máxima por diseño comprendida entre 6 y 25 km/h. Solo pueden estar equipados con un asiento o sillín si están dotados de sistema de autoequilibrado(2). – VMP para transporte personal (alto máximo 140 cm, ancho máximo 75 cm y largo máximo 200 cm) – VMP para transporte de mercancías u otros servicios (alto máximo 180 cm, ancho máximo 100 cm y largo máximo 200 cm. Con una masa máxima admisible de hasta 400 kg) ¿Qué NO es VMP? – vehículos diseñados específicamente para circular fuera de las vías públicas o vehículos concebidos para competición, – los vehículos para personas con movilidad reducida, – los vehículos con una tensión de trabajo mayor a 100 VCC o 240 VCA, – los vehículos considerados juguetes, siendo tales los que su velocidad máxima no sobrepasa los 6 km/h, – vehículos diseñados y fabricados para ser utilizados exclusivamente por las Fuerzas Armadas, – los ciclos de pedales con pedaleo asistido (EPAC), – aquellos vehículos incluidos dentro del ámbito del Reglamento (UE) n.o 168/2013. ¿Quién tiene que solicitar este certificado o manual técncico? El fabricante del VMP o representante autorizado por el mismo será responsable de obtener un certificado de circulación para cada modelo y versión de VMP Van a tener los VMP una placa interna, ¿qué debe reflejar? Tendrán algo parecido a un número de bastidor en el que tiene que poner: – Velocidad máxima. – Número de serie o identificación. – Número de certificado. – Año de construcción. – Marca y modelo. ¿Tendrán que tener retrovisores? Los VMP para transporte de mercancías u otros servicios deberán incluir obligatoriamente 2 retrovisores, a izquierda y derecha del vehículo, con el campo de visión que se especifica en la reglamentación vigente para los retrovisores de Clase L, y con una superficie útil cada uno de ellos de al menos 75 cm2. ¿Qué tipo de ensayos se les van a pedir? – 1 Ensayos de velocidad máxima. – 2 Ensayos de frenado. – 4 Ensayos de comportamiento dinámico. – 6 Ensayos sobre los requisitos eléctricos - apartados A y B. – 7 Ensayos de apagado eléctrico. – 9 Ensayos de cierre combinado - apartado B. Más episodios hablando de patinetes eléctricos o VMP (Vehículos de movilidad personal) • Patinetes eléctricos (VMP) al descubierto con CESVIMAP en AutoFM https://www.ivoox.com/patinetes-electricos-vmp-al-descubierto-cesvimap-audios-mp3_rf_73012940_1.html • VMP o los patinetes eléctricos. HOY PUEDE SER UN GRAN DÍA. RiveConsejo 29 https://www.ivoox.com/vmp-o-patinetes-electricos-hoy-puede-ser-audios-mp3_rf_58970634_1.html • P88. En la sección de RiveKids dentro de AutoFM hablamos de atropellos de niños con patinete eléctrico VMP. https://www.ivoox.com/p88-en-seccion-rivekids-dentro-de-audios-mp3_rf_68488690_1.html • P54 109 víctimas por accidentes con patinete eléctrico (VMP) y 6 fallecidos en 2020. https://www.ivoox.com/p54-109-victimas-accidentes-patinete-electrico-audios-mp3_rf_65740997_1.html • La DGT da un paso para legalizar los VMP o patinetes eléctricos. HOY PUEDE SER UN GRAN DÍA. RiveConsejo 39 https://www.ivoox.com/dgt-da-paso-para-legalizar-los-audios-mp3_rf_60731789_1.html • P39 El 80% de los accidentados en patinete eléctrico iban sin casco https://www.ivoox.com/p39-el-80-accidentados-patinete-audios-mp3_rf_64652023_1.html • P162 Aplicación que detiene el patinete eléctrico si circula mal https://www.ivoox.com/p162-aplicacion-detiene-patinete-electrico-si-audios-mp3_rf_73982087_1.html Hasta aquí el programa de hoy del podcast de seguridad vial y educación vial de RiveKids. Para un asesoramiento 100% personalizado te esperamos en atencion.cliente@rivekids.es También puedes seguirnos en https://www.rivekids.com/ https://www.rivemove.com/ https://www.opinionesrivekids.com/ https://www.rivekidsopiniones.com/ https://autofm.es/adaptador-sillas-coche-con-isofix-rivemove-rivekids/ https://www.alquilersillascoche.com/ http://www.seguridadvialrivekids.com/ Estudio sobre la seguridad infantil en los coches: https://www.rivekids.com/analisis-de-seguridad-infantil-euro-ncap/ Estudio sobre el contenido de las series de Netflix, HBO y Prime Vídeo en seguridad vial: https://www.rivekids.com/seguridad-vial-series-rivekids/ Estudio de perfiles sociológicos de las familias en el entorno escolar: https://www.rivekids.com/vuelta-al-cole-seguridad/ Estudio golpe de calor: https://www.rivekids.com/estudio-golpe-calor-coche-ninos/ Estudio accesorios aftermarket en el interior del coche: https://www.rivekids.com/accesorios-aftermarket-rivekids/ Estudio sobre la plaza más usada para instalar sistemas de retención infantil: https://www.rivekids.com/estudio-rivekids-plazas-mas-usadas-sri-espana/ RiveMove: https://www.diariodesevilla.es/sevilla/Rivemove-accesorio-creado-Rivekids-seguridad_0_1573042950.html Instagram RiveKids: https://www.instagram.com/rivekids/ Twitter RiveKids: https://twitter.com/RiveKids Facebook RiveKids: https://es-es.facebook.com/rivekids Linkedin RiveKids: https://es.linkedin.com/company/rivekids “El verdadero viaje es el que termina como comenzó, con felicidad e inocencia” Feliz viaje hasta el próximo programa.

Get yourself and your loved ones the perfect gift with up to 40% off.Check out Ana Luisa https://shop.analuisa.com/sustainablepackaging I know you'll LOVE them! https://epacflexibles.com/What is the minimum run for digital pouches at Epac? Can you believe the can change the print in less than 2 seconds? 53% PCR!! https://www.linkedin.com/company/epacflexiblepackaging/Check out @corygated on Tiktok https://www.linkedin.com/in/cory-connors-780b9993/https://ororapackagingsolutions.com/Looking to improve the sustainability of your packaging today? Check out: https://www.landsberg.com/ https://specright.com/ https://www.amazon.com/dp/1329820053/ref=as_sl_pc_qf_sp_asin_til?tag=corygated77-20&linkCode=w00&linkId=af630ccba1c41b01bca6fd0e0120360b&creativeASIN=1329820053

ePac Flexible Packaging's Ryan Kiley joined Ed on the Cannacurio Podcast to talk about the some of the fascinating technologies they're working with, how he views the market, and much more! ePac Flexible Packaging is a digitally-based flexible packaging company driven by our mission to help brands of all sizes stay competitive with exceptional stand up pouches, lay flat pouches and rollstock. ePac leverages the latest in digital print technology, providing our customers with a quick and easy way to produce custom printed flexible packaging. Find out more at https://epacflexibles.com. Head over to http://www.cannabiz.media/cannacurio for a full transcription and find us on social media for more clips of new and upcoming episodes. Visit http://www.cannabiz.media to join thousands of reputable companies from around the world who are engaging and connecting with the cannabis and hemp industry! You can also find the Cannacurio Podcast on Apple Podcasts, Spotify, and iHeartRadio.

Wayne Robinson, editor of Print21, and Lindy Hughson, publisher of Print21 and PKN Packaging News, bring us a review and analysis of the major developments, issues and trends emerging in the ANZ print industry during September.Covid is impacting the print industry and we look at which areas are hurting and which are doing well in Australia and New Zealand. Workplace vaccination will be the biggest issue of the year, News Limited is the first printer to mandate vaccinations, we discuss the issues. The route out of Covid does present opportunities for printers, we look at Snap Printing's initiative to assist with the Covid recovery.September has seen some major investments in print around the country, we look at who is spending, why and what they hope to achieve as they back themselves to meet the changing demands of the market.One of those investments is ePac establishing its first digital packaging print service in Australia, building a brand new plant, modelled on the 20 it has around the world. The podcast discusses why ePac is opening here, what trends it is hoping to exploit, and what it means for the rest of the industry.It hasn't all been good news this month, we have seen the dramatic reduction in paper imports over the past year, and we also discuss Ovato's results for the previous financial year. Then there is the stock market shifting to digital trade information, and Australia Post's two week ban on unaddressed mail.The episode wraps with discussions on the increases in shipping prices, a Chinese web-to-print company placing one of the biggest press orders we've ever seen and the good news that the PICAs are back at both the state and national levels.------------------------------The Print Files Podcast is produced by Southern Skies Media on behalf of Print21, owned and published by Yaffa Media.The views of the people featured on this podcast do not necessarily represent the views of Print21, Yaffa Media, or the guest's employer. The contents are copyright by Yaffa Media.If you wish to use any of this podcast's audio, please contact Print21 via their website www.print21.com.au or send an email to editor@print21.com.auCoordinator: Grant McHerronHost: Wayne RobinsonProducer: Steve VisscherPrint21 - © 2021

Responding to a very large number of carbon sequestration inquiries, the Alberta Government issued an Information Letter that proposes a centralized hub model for storing carbon in the province. This week, Tristan Goodman, the President of the Explorers and Producers Association of Canada (EPAC) joins the podcast to offer his perspective on Carbon Capture Utilization […] The post Alberta CCUS Policy: An Interview with Tristan Goodman the President of EPAC first appeared on ARC Energy Research Institute.

US equities mostly flat today on what was a quiet news day. Focus continues to be on the infrastructure deal with both parties pressuring the white house as to what will happen with the larger package and if it will be linked to the current bill. Elsewhere there was focus from the DoJ on Google's ad business, a big rise in home prices and positive variant vaccine news. Tickers mentioned: GOOG, CERE, EPAC, AMZN, LZ, PRPL, MLHR, FOXA

Very insightful episode this week off the media stir of the epic firing of Rory from the Joe Budden Podcast. We get into some deep discussions, besides our usual jokes so tune in and leave us a comment & rating! Intro Songs Moula 1st, Yung Lava - Tiger Blood 2 https://www.youtube.com/watch?v=f7daJ161LDI Dre Barrs - 54 Infants https://www.youtube.com/watch?v=bDF-UZPnnkQ Joe Budden - Uncle Joe https://open.spotify.com/track/7DnobtbJ10iZYhgdFLAW3X?si=9aaeff2bee2a44d2 ______________________________________________________________Topics In Order - Brandon Gonez Interview with Justin Trudeau - Lava tweets were maybe not cap! - Joe Budden Podcast fires Rory On-air- Why Akedemiks Fired Toronto Rapper/ Producer Chosen? -Drake will receive the Artist of the Decade Award at the 2021 billboard Music Awards - Is it ok for a rapper to work a 9-5 ______________________________________________________________Intro Drop Beat by Big Tweeze:https://www.instagram.com/bigtweeze/______________________________________________________________Top 6 Videos In Canada1. Cholocash - Bad News 2. Droops Holiday - 6 Wave Ft. King Dapz 3. Mali Fresco - Fresco Freestyle 4. Lil Bandkamp x Rock$tar - Chatr Chip 5. FM x Msav x Houligan - Dead End 6. J Neat - Get Dem Rackz____________________________________________________________Honorable Mentions1k - Freestyle Pt.2 Hitmaker ft Dutchess - Trust Issues Blacka Da Don - No More Partys & QuickSand Virgo - Fluent Flamez - Fuckery YTS Jaypop - Trap Star HighRollerYM - Intro GizzleStarrMade - Blicky Trystan Laurent - Hell and Back Mjay x Epac ft Vizion - Metal Ring SKIIFALL - Bentayga Dust Mike Shabb - unh yuh Andy Davis & Bellez iles - AVERSE Tripp Flip - Fly Away UTG TwoTone x Lil Mighty - Smoke For The Low Dyces Trench - Projects NSG.6ix - Can't Help ItSMOKE BREAK TUNE: Frankie Payne - Ugly Truth https://open.spotify.com/track/6AuslSWtU0Scr5BldfWuAg?si=5c7a5f6c013f438b ROAD TUNE: Bvlly - Airplane Mode https://www.youtube.com/watch?v=2Hdh3ALTTtA ______________________________________________________________We Love Hip Hop: www.instagram.com/welovehiphopnetwork/Friday: www.instagram.com/fridayrickydred/PK Herc: www.instagram.com/pkhercs/Gucci 416: www.instagram.com/g_u_c_c_i_416/Guttzy Guttz: www.instagram.com/guttzyguttz/

Very insightful episode this week off the media stir of the epic firing of Rory from the Joe Budden Podcast. We get into some deep discussions, besides our usual jokes so tune in and leave us a comment & rating! Intro Songs Moula 1st, Yung Lava - Tiger Blood 2 https://www.youtube.com/watch?v=f7daJ161LDI Dre Barrs - 54 Infants https://www.youtube.com/watch?v=bDF-UZPnnkQ Joe Budden - Uncle Joe https://open.spotify.com/track/7DnobtbJ10iZYhgdFLAW3X?si=9aaeff2bee2a44d2 ______________________________________________________________ Topics In Order - Brandon Gonez Interview with Justin Trudeau - Lava tweets were maybe not cap! - Joe Budden Podcast fires Rory On-air - Why Akedemiks Fired Toronto Rapper/ Producer Chosen? -Drake will receive the Artist of the Decade Award at the 2021 billboard Music Awards - Is it ok for a rapper to work a 9-5 ______________________________________________________________ Intro Drop Beat by Big Tweeze: https://www.instagram.com/bigtweeze/ ______________________________________________________________ Top 6 Videos In Canada 1. Cholocash - Bad News 2. Droops Holiday - 6 Wave Ft. King Dapz 3. Mali Fresco - Fresco Freestyle 4. Lil Bandkamp x Rock$tar - Chatr Chip 5. FM x Msav x Houligan - Dead End 6. J Neat - Get Dem Rackz ____________________________________________________________ Honorable Mentions 1k - Freestyle Pt.2 Hitmaker ft Dutchess - Trust Issues Blacka Da Don - No More Partys & QuickSand Virgo - Fluent Flamez - Fuckery YTS Jaypop - Trap Star HighRollerYM - Intro GizzleStarrMade - Blicky Trystan Laurent - Hell and Back Mjay x Epac ft Vizion - Metal Ring SKIIFALL - Bentayga Dust Mike Shabb - unh yuh Andy Davis & Bellez iles - AVERSE Tripp Flip - Fly Away UTG TwoTone x Lil Mighty - Smoke For The Low Dyces Trench - Projects NSG.6ix - Can't Help It SMOKE BREAK TUNE: Frankie Payne - Ugly Truth https://open.spotify.com/track/6AuslSWtU0Scr5BldfWuAg?si=5c7a5f6c013f438b ROAD TUNE: Bvlly - Airplane Mode https://www.youtube.com/watch?v=2Hdh3ALTTtA ______________________________________________________________ We Love Hip Hop: www.instagram.com/welovehiphopnetwork/ Friday: www.instagram.com/fridayrickydred/ PK Herc: www.instagram.com/pkhercs/ Gucci 416: www.instagram.com/g_u_c_c_i_416/ Guttzy Guttz: www.instagram.com/guttzyguttz/

In episode 104 of the American Reveille Podcast, I bring Hugo Goerner, author of United States Socialist Republic, back on the show. Hugo and I have an hour-long conversation about his new organization "Ensure the Preservation of America and Our Constitution" (EPAC), the overwhelming migrant border crisis, Marxist militant groups, how the Democrats move "clean" money around to pay for their "dirty deeds," and the policies being pushed to support them.  Please check out this episodes sponsor ANCIENT LIFE OIL and use promo code JAMES for free shipping - http://ow.ly/GFWR50DPzP1You can purchase a copy of Hugo Goerner's informative book "United States Socialist Republic" here - http://ow.ly/XrRM50E5OuUYou can find more information about EPAC here - http://ow.ly/Li4b50E5OuTSUPPORT US:Donate - http://ow.ly/9ckY50DA5c2Newsletter - http://ow.ly/3ha850DFm0oVIDEO:YouTube - http://ow.ly/enQk50DA5bnRumble - http://ow.ly/BVx550DA573Odysee - http://ow.ly/utOG50DA571AUDIO:Apple Podcasts - http://ow.ly/Nlsw50zvkUTSpotify - http://ow.ly/gOON50zPya7SOCIAL:Parler - http://ow.ly/QNma50AwfEgGab - http://ow.ly/w3kq50DA56ZInstagram - http://ow.ly/BN7h50DA56YMinds - http://ow.ly/Y6bO50DA572AR Website - http://ow.ly/eO3g50DA5bo

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.10.290825v1?rss=1 Authors: Baillie, G. S., Tibbo, A., Dobi, S., McFall, A., Tejeda, G. S., Blair, C., MacLeod, R., MacQuaide, N., Gok, C., Fuller, W., Smith, B., Smith, G., Brand, T. Abstract: Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific responses. The cAMP effector proteins protein-kinase A and EPAC are found in complexes that also contain phosphodiesterases whose presence ensures a coordinated cellular response to receptor activation events. Popeye proteins are the most recent class of cAMP effectors to be identified and have crucial roles in cardiac pacemaking and conduction. We report the first observation that Popeye proteins exist in complexes with members of the PDE4 family in cardiac myocytes thus restricting cAMP signaling. We show that POPDC1 preferentially binds the PDE4A sub-family via a specificity motif in the PDE4 UCR1 region and that PDE4s bind to the Popeye domain of POPDC1 in a region known to be susceptible to a mutation that causes human disease. Using a cell-permeable disruptor peptide that displaces the POPDC1-PDE4 complex we show that PDE4 activity localized to POPDC1 is essential to maintain action potential duration in beating cardiac myocytes. Copy rights belong to original authors. Visit the link for more info

In our second expansion pack Paul Baba joins the show to talk about his comic book "Little Ball of Hate." Paul is an artist in the Phoenix area. He is writing, drawing, and publishing a digital comic book, which is available now on Amazon Kindle. Paul and I talk about what made him decide to publish his own content and how it easy it is for other creators to do the same.

Guests Peter McCaffrey, President of the Alberta Institute, Tracey Wilson VP of Public Relations at the Canadian Coalition for Firearm Rights, Dave Humphreys is on the Executive Team of Birchcliff Energy Ltd and is the current Chair of EPAC, the Explorers and Producers Association of Canada, and John Redfern, CEO of Eavor

Guest Dave Humphreys is on the Executive Team of Birchcliff Energy Ltd and is the current Chair of EPAC, the Explorers and Producers Association of Canada

Packaging is more than just the container you put your product in. It should also amplify your brand message. It should help sell your brand. Packaging can be very confusing – we make it simple and straight forward on this episode. What you need to know. This episode's FREE downloadable guide This short guide levels the playing field between small brands and their more sophisticated competitors. It highlights the advanced strategies the big brands use called Category Management - what retailers want.  CLICK HERE TO DOWNLOAD YOUR FREE STRATEGIC GUIDE: Strategic Solutions To Grow Your Brand Welcome. Thank you for listening. This podcast is dedicated to helping you get your product on more store shelves and into the hands of more shoppers. Now there’s a lot to it before you can actually get your product on a retailer’s shelf. In this episode we’re going to talk about packaging. While this is a topic I’ve covered in great detail on other episodes about compostable packaging, recyclable packaging, what the difference is, what you need to know, et cetera, the focus on this episode is on answering those questions. What do you need to know when you think about putting your product in a package? Who do you go to? Do you go to a packaging broker, or do you go directly to the converter? A converter is an industry term. These are the people that work the magic to create the packaging that your product goes in, the packaging that you see on retailer shelves. What questions do you need to ask them? What are the options that are available to you as a brand, and then how does that packaging supplier work with your co-packer, your marketing company, and anyone else who’s involved in designing your packaging and your product? Essentially everything that has to go on behind the scenes before you can get your product on more store shelves and into the hands of more shoppers. But before we can go down that path we’ve got to talk about some of the other very important elements that you need to have in place before you even develop your packaging. For example, how can your packaging to tell a compelling story about your brand? What are some of the ways that you can leverage your packaging to help grow incremental sales to make it easier for a retailer to say yes to your product? What can you do to catch the consumer’s eye so that they buy more product and then evangelize your product to their friends? Once you come up with your packaging design, what’s next? What format does it need to be in and how does that work? What are the limitations around your packaging? How customized can you make your packaging? What are some of the different strategies and technologies that you can take advantage of today to gain a significant competitive advantage in your category? Then more importantly, what are the different options available to you? This can vary greatly depending on what kind of product you have, whether it’s hot, cold, how much liquid is in it. There’s a lot to know here. Anyhow, don’t fret. This no longer needs to keep you up at night. This podcast episode is dedicated to answering many of those questions that you have, plus a whole lot more. In preparing for this episode I actually made a list of all the questions that brands ask me when I mentor and work with them. You’re going to hear a lot of them repeated here, and a lot of those questions get addressed. If there are any questions that weren’t addressed here, you can always reach out to me via email or any social platform, or you can reach out to our guest today. Download the show notes:  brandsecretsandstrategies.com/session130

Förster (Fluorescence) Resonance Energy Transfer (FRET) has become a powerful tool to study protein-protein interactions and signal transduction in living cells. FRET is commonly read out either by detecting the ratio of the donor and acceptor intensities (sensitized emission) or by detecting the excited state lifetime of the donor, which decreases with increasing FRET (Fluorescence Lifetime IMaging or FLIM). FLIM is robust, immune to bleaching and inherently quantitative. On confocal microscopes, FLIM is typically read out by Time-Correlated Single Photon Counting (TCSPC). This requires expensive add-on hardware and is inherently very slow, necessitating accumulation of many consecutive scans to arrive at low-noise lifetime images. For this reason fast lifetime changes, such as those encountered when reading out live-cell signaling events with FRET sensors, cannot be detected. Accumulation of images and/or very slow scanning can also cause morphological artifacts in the acquired images. We present the Leica SP8 FALCON, a new high-end confocal instrument with built-in very fast FLIM capabilities. The instrument applies a novel technology to records photon arrival times at up to 80 MHz (160 MHz if two detectors are used) using the built-in spectral HyD detectors. To arrive at such high counts rates, the instrument uses real-time 10 GHz sampling and analysis algorithms that render it largely immune to pulse pile-up. Falcon FLIM has been fully integrated in the LAS-X software, allowing convenient acquisition of FLIM time-lapses, stitched FLIM overview images, FLIM XYZ-stacks and spectral FLIM stacks, among others, as well as combinations thereof. We scrutinized the performance of the SP8 FALCON and applied it to record agonist-induced changes in concentration of second messengers such as cAMP and Ca2+ with sub-micrometer precision at high speed- on the order of several (512×512) frames per second (FPS). To detect cAMP by FLIM, we used our newest generation of EPAC-based dedicated FLIM sensors, which use mTurquoise2 as a donor and a tandem of two monomeric dark Venus proteins as acceptors. Reducing the image format to 128×128 pixels, we acquired good quality FLIM time-lapses at 25 FPS (83 FPS using resonant scanning), allowing detection of even very fast signaling events, including e.g. the activation of G-proteins and Ca2+ sparks. The large numbers of detected photons reduce pixel-to-pixel variability in the calculated lifetimes. Finally we demonstrate that the SP8-FALCON is ideal for fast FLIM screening applications in both fixed- and live-cell formats.

Lisa Landis welcomes friends from the cast of "Annie" at the Ephrata Performing Arts Center to The Kids Cookie Break!

Earlier this year Ed was in a production of "One Flew Over The Cuckoo's Nest" directed by the extremely talented Tim Riggs. After a few months of coordinating schedules (understandably difficult as Tim is both a new husband and a new father), Tim and Ed were finally able to sit down and talk about acting, directing, the craft, and John Denver.

-TUMORE, AL VIA LA CARTA EUROPEA DEI DIRITTI DEL MALATO Nasce la Carta Europea dei Diritti del Malato di Cancro. È presentata oggi in occasione della Giornata mondiale contro il Cancro, a Strasburgo, con la partecipazione del Commissario Europeo per la Salute, Tonio Borg. Il documento è realizzato grazie ad una forte alleanza tra associazioni di pazienti (European Cancer Patients Coalition - ECPC) ed esperti in ricerca, innovazione e advocacy del “pianeta cancro” (European Cancer Concord – ECC), con il sostegno condiviso dell’Associazione degli Europarlamentari contro il cancro (MAC). La Carta è una vera e propria chiamata alle armi delle istituzioni europee e nazionali per un impegno concreto nell’affrontare l’epidemia di cancro che colpisce l’Europa e che porterà alla morte di 1 malato ogni 10 secondi nei prossimi 20-25 anni. In Italia nel 2013 sono state registrate 366mila nuove diagnosi e 173mila decessi. L’Italia ha contribuito concretamente alla redazione della Carta Europea dei Diritti del Malato di Cancro grazie al lavoro della Federazione italiana delle Associazioni di Volontariato in Oncologia (FAVO) e dell’Associazione Italiana Malati di Cancro, parenti e amici (AIMaC). La Carta Europea dei Diritti del Malato di Cancro è uno Statuto del Paziente che punta a risolvere le diseguaglianze che le persone affette da neoplasie affrontano ogni giorno in Europa, principalmente legate a status socioeconomico, età anagrafica, accesso a cure di qualità e mancanza di un Piano Oncologico Nazionale. Il cancro pesa sull’economia di tutto il mondo per un valore complessivo che sfiora i 1.000 miliardi di Euro, cosa che ne fa la malattia numero 1 in termini di prosciugamento delle risorse finanziare globali. -EPATITE C: SI PUO’ GUARIRE. CAMPAGNA EPAC E' partita oggi la campagna nazionale: “Epatite C – Le novità ci sono. Informati adesso”, promossa da EpaC Onlus, con l’obiettivo di sensibilizzare i pazienti con Epatite C affinché si informino sulle attuali opportunità di cura della patologia presso la rete dei Centri specialistici autorizzati dall’AIFA. L’Italia è il Paese europeo con il maggior numero di persone positive al virus dell’Epatite C: circa il 3% della popolazione italiana è entrata in contatto con l’HCV. Si stima che i portatori cronici siano almeno 1,6 milioni, di cui 330.000 con cirrosi epatica. Di questi, ogni anno, circa 20.000 muoiono per malattie croniche del fegato causate dall’Epatite C. Si tratta di una malattia subdola perché nella maggior parte dei casi rimane asintomatica per anni o addirittura per decenni, ma silenziosamente il virus lavora, provocando gravi danni al fegato. Quasi la metà dei pazienti può sviluppare cirrosi nell’arco di 25-40 anni, altri possono sviluppare manifestazioni extraepatiche, come vasculiti e danni renali fino ad arrivare all’epatocarcinoma e al trapianto. È importante eradicare il virus prima che si sviluppino questi elementi di gravità clinica. -DIABETE, LA DISINFORMAZIONE UCCIDE. APPELLO SID - AMD Le Società Scientifiche e Professionali di Diabetologia e le Associazioni delle persone con diabete denunciano come, con sempre maggiore insistenza, vengano presentate al pubblico e alle persone con diabete sulla rete e sui giornali ‘soluzioni’ miracolistiche, in larga parte basate su diete drastiche (cibi crudi, diete alcaline, vegetariane o altro), con la promessa di ‘guarire’ in pochi giorni il diabete e di abbandonare le terapie farmacologiche, inclusa l’insulina. La comunità scientifica nazionale e internazionale, l’Organizzazione Mondiale della Sanità e lo stesso Ministero della Salute da decenni sostengono a chiare lettere che la migliore prevenzione del diabete mellito è e rimane una sana igiene di vita (regolare attività fisica, dieta equilibrata e sana, moderato consumo di alcool e abolizione del fumo). Il fatto che la dieta sia un pilastro fondamentale del trattamento del diabete è un dato indiscutibile e irrinunciabile. Il problema nasce quando la terapia dietetica viene proposta come unica alternativa ai farmaci. Questo rischia, infatti, di creare situazioni estremamente pericolose, soprattutto per le persone con diabete di tipo 1 che, senza insulina possono andare incontro a condizioni a rischio di vita. Il diabete tipo 1 è una malattia che deriva dalla perdita delle cellule che producono l’insulina, per distruzione autoimmunitaria, per cui l’organismo ne diventa totalmente privo. -ANMCO: “SETTIMANA DEL CUORE” DAL 10 AL 16 FEBBRAIO Nella “Settimana del Cuore” in oltre 700 ospedali italiani i cardiologi ANMCO saranno a disposizione dei cittadini per incontri formativi, visite gratuìte ed iniziative educative. La Campagna sarà sostenuta anche dalle squadre della Serie A del Campionato di Calcio, che il 16 febbraio dedicheranno alla “salute del cuore” la 24a giornata di campionato. A sostegno dell'iniziativa anche la Federazione Italiana Gioco Calcio attraverso il Commissario Tecnico della Nazionale Cesare Prandelli, che parteciperà alla realizzazione di uno spot come testimonial della Campagna. La “settimana del cuore” sarà inoltre l'occasione per una raccolta fondi da dedicare alla ricerca e alla prevenzione cardiovascolare.

Background: Prostate smooth muscle tone is regulated by alpha 1-adrenoceptor-induced contraction and cAMP-mediated relaxation. EPAC is an effector of cAMP, being involved in smooth muscle relaxation and cell cycle control outside the lower urinary tract. Here, we investigated the expression and function of EPAC in human prostate tissues from patients undergoing radical prostatectomy. Results: mRNA and protein expression of EPAC was detected in all prostate tissues by RT-PCR and Western blot analysis. Immunoreactivity was observed in stromal cells, and colocalized with immunofluorescence for a-smooth muscle actin and calponin. Under normal conditions, noradrenaline-or phenylephrine-induced contraction of prostate strips in the organ bath was not affected by the EPAC activator pCPT (SP-8-pCPT-2'-O-Me-cAMPS.NA) (30 mu M). However, when the cyclooxygenase inhibitor indomethacin (50 mu M) was added, EPAC activators pCPT and OME (8-CPT-2'-O-Me-cAMP.Na) (30 mu M) significantly reduced contractions by low concentrations of phenylephrine. These effects were not observed on noradrenaline-induced contraction. OME and pCPT caused phosphorylation of the transcription factor Elk1 in prostate tissues. Elk1 activation was confirmed by EMSA (electrophoretic mobility shift assay), where OME and pCPT incresed Elk1 binding to a specific DNA probe. Conclusions: EPAC activation may reduce alpha 1-adrenergic prostate contraction in the human prostate, although this effect is masked by cyclooxygenases and beta-adrenoceptors. A main EPAC function in the human prostate may be the regulation of the transcription factor Elk1.

Eny2, the mammalian ortholog of yeast Sus1 and drosophila E(y)2, is a nuclear factor that participates in several steps of gene transcription and in mRNA export. We had previously found that Eny2 expression changes in mouse pancreatic islets during the metabolic adaptation to pregnancy. We therefore hypothesized that the protein contributes to the regulation of islet endocrine cell function and tested this hypothesis in rat INS-1E insulinoma cells. Overexpression of Eny2 had no effect but siRNA-mediated knockdown of Eny2 resulted in markedly increased glucose and exendin-4-induced insulin secretion from otherwise poorly glucose-responsive INS-1E cells. Insulin content, cellular viability, and the expression levels of several key components of glucose sensing remained unchanged; however glucose-dependent cellular metabolism was higher after Eny2 knockdown. Suppression of Eny2 enhanced the intracellular incretin signal downstream of cAMP. The use of specific cAMP analogues and pathway inhibitors primarily implicated the PKA and to a lesser extent the EPAC pathway. In summary, we identified a potential link between the nuclear protein Eny2 and insulin secretion. Suppression of Eny2 resulted in increased glucose and incretin-induced insulin release from a poorly glucose-responsive INS-1E subline. Whether these findings extend to other experimental conditions or to in vivo physiology needs to be determined in further studies.