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Learn more about Refrigeration Mentor Customized Technical Training Programs at www.refrigerationmentor.com/courses Join the Refrigeration Mentor Hub here In this conversation, I sit down with Supermarket Refrigeration Technician Jacob Decker to discuss how newer technicians can land opportunities and gain experience faster. Jacob shares how he moved from residential work and tech school into commercial refrigeration and a full time career with Walmart through connections, overcoming fears, learning form mistakes, and how he benefited from mentorship and structured training. We also cover common challenges for new techs, plus practical habits to build that will fast track the learning curve and open up so many opportunities for building your career in the industry. In this episode, we discuss: (01:19) Breaking Into Refrigeration (02:44) First Commercial Job Lessons (05:42) Biggest Surprises and Challenges Entering Refrigeration (07:20) Learning from Mistakes (12:39) Mentorship and Generational Shifts in the Trades (16:10) Common Pitfalls for New Refrigeration Techs (18:32) Building ConfideEpisode 186: How To Attract Young People To The Refrigeration Trade (20:40) Checklists (25:08) Future Refrigeration Tech and CO2 (26:47) Work-Life Balance in Refrigeration (28:35) Building Better Work Habits (34:42) Mental Health in the Trades Helpful Links & Resources: Episode 85. Generation Z with love2hvac Episode 186: How To Attract Young People To The Refrigeration Trade With Rusty Walker Episode 190. Turning Mistakes Into Lessons and Accelerating Your Refrigeration Career with Andrew Freeburg
Why does life-saving insulin cost hundreds of dollars a month for patients, when manufacturing costs are just a fraction of that price? What if the nonprofit model could change everything for affordable access?In the pharmaceutical industry, affordability and access remain two of the biggest hurdles for patients, especially when the economics of essential medicines seem stacked against them.Eric Moyal, founder of Project Insulin, is rewriting the rules of biosimilar development. Coming from a fundraising and nonprofit background rather than the pharma inside track, Eric built Project Insulin not to chase profits, but to deliver an essential therapy at a price real people can afford.Topics covered:Key differences between nonprofit and for-profit models in biotech, especially around fundraising, incentives, and revenue (00:02)The intricate balance between development costs, operating expenses, and setting an affordable price point (00:06)Innovative distribution models to eliminate price inflation by middlemen, including direct-to-patient and clinic partnerships (00:08)Major roadblocks in reinventing drug distribution and the importance of building the right partnerships early on (00:10)Advice for founders and scientists exploring solutions to drug affordability, including corporate structure, fundraising, and perseverance (00:12)Lessons learned after five years building Project Insulin, emphasizing the value of assembling the right team and listening to feedback (00:13)Realistic expectations for Project Insulin's next five years and the primary goals on the horizon (00:16)The broader need for affordable generic drugs and the broken promise of the current patent system (00:17)How to connect with Project Insulin and support its mission (00:18)Smart insight: Generic medicines should be affordable. Ensuring low-cost, accessible generics is essential to restoring the original balance between pharmaceutical innovation and public access, and it requires collective effort beyond any single player.If you enjoyed this episode, you might want to listen to these within a broader set of discussions on biologics affordability, CMC strategy, and bioprocessing realities — from the economic barriers blocking patient access and regulatory decision-making for biosimilars, to CDMO selection for resource-constrained teams:Episode 136: 5 Roadblocks to Affordable Biologics (And How to Overcome Them)Episodes 57 - 58: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls with Matthias MüllnerEpisodes 103 - 104: One-Stop Shop vs. Specialist CDMO: A Scientist's Guide to CDMO Selection with Sigma MostafaConnect with Eric Moyal:Email: emoyal@projectinsulin.orgWebsite: www.projectinsulin.orgInstagram: www.instagram.com/projectinsulinLinkedIn: www.linkedin.com/company/82500193TikTok: www.tiktok.com/@project.insulinYouTube: www.youtube.com/@ProjectInsulinNext step: If you enjoyed this episode, please leave a review on Apple Podcasts or your favorite podcast platform. By doing so, we can empower more scientists like you. Stay tuned for more inspiring biotech insights in our next episode.Support the show
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Insulin was first discovered over a century ago—yet in the United States, 1 in 5 insulin-dependent patients still ration their lifesaving supply. Why is a molecule so essential, and so well understood, still so out of reach for so many?Eric Moyal, founder of Project Insulin, decided to challenge not just the science, but the business model itself. With a background in nonprofit fundraising—not drug development—he's building a biosimilar insulin glargine and promising to sell it directly to patients at cost, insurance or not.Topics discussed include:The origins of the insulin affordability crisis and the impact of profit-driven healthcare systems (04:27)How over a million Americans are forced to ration their insulin every month, and the broader impact on patients' (lives 06:37)The advantages and challenges of approaching drug development with a background outside of biotech (08:37)The fundraising-focused strategy for overcoming scientific and technical hurdles in developing biosimilar insulin (09:17)Technical details on Project Insulin's development process, including selection of CDMOs, importance of analytical data, and process challenges like reverse-phase cleaving and crystallization (11:16)The impact of recent FDA regulatory changes on the development and approval pathway for biosimilars in the U.S. (15:45)Smart insight: A nonprofit approach to essential medicines could reshape the future for patients who depend on them. By removing shareholder expectations and focusing on affordability and access, leaders like Eric Moyal are proving new paths are possible—not through incremental science alone, but through bold re-imaginings of how science serves the public.If you enjoyed this episode, you might want to listen to these within a broader set of discussions on biologics affordability, CMC strategy, and bioprocessing realities — from the economic barriers blocking patient access and regulatory decision-making for biosimilars, to CDMO selection for resource-constrained teams:Episode 136: 5 Roadblocks to Affordable Biologics (And How to Overcome Them)Episodes 57 - 58: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls with Matthias MüllnerEpisodes 103 - 104: One-Stop Shop vs. Specialist CDMO: A Scientist's Guide to CDMO Selection with Sigma MostafaConnect with Eric Moyal:Email: emoyal@projectinsulin.orgWebsite: www.projectinsulin.orgInstagram: www.instagram.com/projectinsulinLinkedIn: www.linkedin.com/company/82500193TikTok: www.tiktok.com/@project.insulinYouTube: www.youtube.com/@ProjectInsulinNext step: If you enjoyed this episode, please leave a review on Apple Podcasts or your favorite podcast platform. By doing so, we can empower more scientists like you. Stay tuned for more inspiring biotech insights in our next episode.Support the show
Behavioral health services continue to face heightened payer scrutiny. The result: inaccurate documentation, coding, and compliance issues.Panacea Healthcare recently hosted a webinar that focused on three high-risk areas: relative to Behavioral Health–telehealth, psychotherapy with evaluation and management (E&M) services, and the Collaborative Care Model (CoCM).Special guest George Kelly is expected to summarize these issues while outlining the common compliance pitfalls, documentation requirements, coding best practices, and audit risks associated with each service.Broadcast segments will also include these instantly recognizable features:• Monday Rounds: Ronald Hirsch, MD, vice president of R1 RCM, will be making his Monday Rounds.• The RAC Report: Healthcare attorney Knicole Emanuel, partner at the law firm of Nelson Mullins, will report the latest news about auditors.• Risky Business: Healthcare attorney David Glaser, shareholder in the law offices of Fredrikson & Byron, will join the broadcast with his trademark segment.• Legislative Update: Adam Brenman, legislative affairs analyst for Zelis, will report on current healthcare legislation.
Learn how ketones can boost your energy, cognition, and overall health. This guide is perfect for anyone curious about the science behind ketones and their benefits. In today's fast-paced world, many people are searching for ways to enhance their energy, focus, and overall health. One such method gaining traction is the use of ketones. In this post, we will dive deep into what ketones are, how they impact our bodies, and why they may be the next big thing in health and wellness.Get Tecton Ketones Here: https://tectonketones.com/discount/LUCAS Chapters: 00:00 Introduction and Guest Introduction00:55 Personal Journey into Health and Optimization02:14 Principles of Naturopathic and Holistic Medicine03:52 Core Principles: Do No Harm and Individualized Care06:28 Focus on Gut Health and Its Central Role08:14 Evolution of Gut Health Strategies in Recent Years10:02 Food Intolerance Testing and Its Significance11:46 Understanding IgG vs IgE Food Reactions13:49 Genetics, Ethnicity, and Food Intolerances15:27 Practical Use of Food Intolerance Tests19:25 Personal Insights from Food Testing22:10 Common Pitfalls in Health Optimization24:44 The Role of Hormones and Foundation of Health27:36 High Effort Strategies and Their Impact30:50 Blood Work Analysis and Functional Medicine44:08 Thyroid Function and Its Impact on Health49:52 Holistic Principles: Body's Self-Regulation and Healing52:07 Practical Advice for Health Optimization52:49 Connecting with Dr. Alex Orton and Final ThoughtsDisclaimer:The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy for more information.
Defending Against Child Abuse Accusations: The Critical Role of Experts and PreparationPart 2 of this conversation with Mark Satawa.The conversation focuses on the intricate challenges of defending cases involving allegations of abusive head trauma and child abuse, particularly those hinging on complex medical evidence.A key theme that emerges is the necessity of thorough preparation, including gathering exhaustive timelines, complete medical records, and independent radiology reviews to fully understand the facts before developing a defense strategy.The discussion explores the crucial role of expert witnesses, highlighting that success depends not just on consulting experts but on finding the right kinds of experts tailored to each unique case.One concept is the danger of allowing ego—whether from doctors or lawyers—to impede objective analysis and best practices in trial preparation. Several points are raised, including the hurdles posed by entrenched medical dogma, the importance of alternative explanations, and the reality that focus groups and mock trials can be invaluable tools for testing strategies before going to court.The episode ultimately serves as both a cautionary and instructive guide for defense attorneys and clients facing emotionally charged, medically complex allegations, emphasizing the need for purpose-driven, detail-oriented advocacy from the very beginning of a case.Moments00:00 Describing the alleged injury report03:59 Defending against accusations in court08:04 Egos in high-stakes legal cases11:29 Differentiating between expert advice14:46 Child abuse pediatrician controversy16:18 Creating detailed client timelines22:30 Radiology's role in expert vetting23:48 Defending child abuse cases29:27 Discussing shaken baby syndrome cases31:38 Discussing alternative explanations34:08 Consulting on legal cases nationwide38:53 Using biomechanical engineers in cases41:35 Planning focus group sessions45:42 Legal defense strategy planning49:25 Prosecutorial misconduct in appeals51:43 Discussing legal guidance for accusations53:42 Importance of being preparedFAQ'sHow do defense lawyers build a strong case in child abuse or abusive head trauma trials?Defense lawyers gather extensive timelines, complete medical records (including original radiology), thorough discovery annotations, and detailed narratives before engaging expert analysis. This thorough, step-by-step approach ensures they discover alternative explanations and prepare a compelling defense based on facts rather than assumptions.Why is it important to use the right experts in shaken baby syndrome legal cases?Using the right experts is crucial because each case may require different specialties (like pediatric neuroradiologists, ER doctors, or biomechanical engineers), and only properly matched experts can challenge the prosecution's medical claims and present credible alternative explanations. The podcast explains that employing the wrong expert or too few experts often leads to convictions, while properly chosen expert teams can result in acquittals.What common mistakes lead to wrongful convictions in abusive head trauma cases?Common mistakes include failing to secure all medical evidence, relying on insufficient or poorly matched experts, and forming theories before gathering complete information. These errors, often stemming from ego or lack of preparation, can cause lawyers to miss viable defenses and lead to wrongful convictions and failed appeals.Submit your questions to www.lawyertalkpodcast.com.Recorded at Channel 511.Stephen E. Palmer, Esq. has been practicing criminal defense almost exclusively since 1995. He has represented people in federal, state, and local courts in Ohio and elsewhere.Though he focuses on all areas of criminal defense, he particularly enjoys complex cases in state and federal courts.He has unique experience handling and assembling top defense teams of attorneys and experts in cases involving allegations of child abuse (false sexual allegations, false physical abuse allegations), complex scientific cases involving allegations of DUI and vehicular homicide cases with blood alcohol tests, and any other criminal cases that demand jury trial experience.Steve has unique experience handling numerous high publicity cases that have garnered national attention.For more information about Steve and his law firm, visit Palmer Legal Defense. Copyright 2026 Stephen E. Palmer - Attorney At LawMentioned in this episode:Circle 270 Media Podcast ConsultantsCircle 270 Media® is a podcast consulting firm based in Columbus, Ohio, specializing in helping businesses develop, launch, and optimize podcasts as part of their marketing strategy. The firm emphasizes the importance of storytelling through podcasting to differentiate businesses and engage with their audiences effectively. www.circle270media.com
In this insightful interview, Antonia Soler, VP of Marketing at Fieldwire and head of Hilti Ventures, shares her career journey from engineering to venture capital, her approach to innovation in construction tech, and advice for startups entering the industry. Discover how her diverse experiences and strategic insights can guide construction startups from prototype to product-market fit. key topics Career highlights and transition from engineering to venture capital Strategies for construction tech startups to reach product-market fit Importance of industry understanding and customer engagement Building a diverse and experienced sales and marketing team Networking, conferences, and global expansion in construction tech Supporting women in construction and industry diversity Chapters 00:00 Antonia Soler's Career Journey 02:43 Navigating Opportunities and Challenges 05:11 The Dynamics of a Week in Marketing 07:31 Investment Strategies in Construction Tech 10:07 Sales and Marketing in Construction Tech 12:36 Masterclass in Startup Growth 14:48 Common Pitfalls for Construction Startups 17:08 Women in Construction Tech Initiative 19:43 Global Networking and Community Building 21:44 Future Initiatives in Construction 24:18 Closing Thoughts and Encouragement
Franco Giaquinto, CEO of Outbuild, shares insights on construction tech, industry challenges, and future trends. Discover how to build trust, focus on value, and navigate the complex landscape of construction innovation. key topics Construction industry challenges and solutions Building trust and credibility in construction tech Strategies for startup growth and focus Future trends in construction technology and AI Chapters 00:00 The Birth of Outbuild 04:03 Overcoming Early Challenges 08:14 Building a Strong Team Culture 12:19 Go-to-Market Strategies and Lessons Learned 16:40 Common Pitfalls in Construction Tech Startups 20:52 The Long Game in Construction Tech 23:18 The Journey of Founders: No Shortcuts 25:42 Sharing Knowledge: Supporting New Founders 27:49 The Importance of Humility in Founding 29:36 Filtering Voices: Who Gets the Mic? 32:27 The Value of Real Conversations 33:59 The Reality of Building Great Products 37:24 Future of Construction Tech: Predictions for 2030
In this episode, Dr. Alex Orton shares his journey into holistic health, emphasizing the importance of foundational practices like gut health, lifestyle, and individualized approaches to optimize well-being. Discover key insights on food intolerances, the evolution of gut health strategies, and practical tips for sustainable health improvements.Relevant links:Alex's Website Link: https://havenholistichealth.com/Chapters: 00:00 Introduction and Guest Introduction00:55 Personal Journey into Health and Optimization02:14 Principles of Naturopathic and Holistic Medicine03:52 Core Principles: Do No Harm and Individualized Care06:28 Focus on Gut Health and Its Central Role08:14 Evolution of Gut Health Strategies in Recent Years10:02 Food Intolerance Testing and Its Significance11:46 Understanding IgG vs IgE Food Reactions13:49 Genetics, Ethnicity, and Food Intolerances15:27 Practical Use of Food Intolerance Tests19:25 Personal Insights from Food Testing22:10 Common Pitfalls in Health Optimization24:44 The Role of Hormones and Foundation of Health27:36 High Effort Strategies and Their Impact30:50 Blood Work Analysis and Functional Medicine44:08 Thyroid Function and Its Impact on Health49:52 Holistic Principles: Body's Self-Regulation and Healing52:07 Practical Advice for Health Optimization52:49 Connecting with Dr. Alex Orton and Final ThoughtsDisclaimer:The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy for more information.
Why do most organizations fail at gap analysis? From treating it like a one-time checkbox to ignoring root causes and skipping follow-through, this episode unpacks the common mistakes that derail strategic improvement—and how leaders can fix them.Learn more at https://www.bluoceantsunami.com/ Blu Ocean Innovations, LLC City: Las Vegas Address: 5940 South Rainbow Boulevard #400 7820 Website: https://bluoceaninnovations.ai
Join us as Mike Fiedler (AWS Hero, PyPI Safety & Security Engineer, Python Software Foundation) makes the case for eliminating long-lived credentials from your release workflow - before an attacker does it for you. Mike walks through the real-world incidents that motivated Trusted Publishing, how OIDC-based short-lived tokens work under the hood, and the step-by-step process for setting it up in GitHub Actions. You'll learn how the 2024 Ultralytics compromise was forensically investigated thanks to Sigstore attestations, why that API token in your repo is just a password with a fancy hat, common pitfalls that will have you debugging for four hours, and why deleting your old token after setup is the step everyone forgets. PyPI went from 10% Trusted Publishing adoption in February 2024 to 36% today - this episode is how you become part of that number. Timestamps 0:00 Welcome & Introduction 4:00 Mike's PyCon US World Tour Recap 8:00 The Scale of PyPI: 13B Requests/Day & 36% Adoption 12:09 Why Long-Lived Tokens Fail: Four Attack Models 16:47 Case Study: The 2024 Ultralytics Compromise 21:44 What is Trusted Publishing? OIDC Explained 27:04 How the GitHub Actions Flow Actually Works 34:12 Other Registries: npm, RubyGems, crates.io, NuGet 36:34 Common Pitfalls & Debugging Tips 42:29 Provenance & Sigstore Attestations 44:22 The Step Everyone Forgets: Delete Your Old Token 47:06 Migration Guide & Getting Started This Week How to find Mike: https://www.linkedin.com/in/miketheman/ https://www.python.org/psf-landing/ Links from the show:
The Future of Tissue Renewal with Dr. Bankole Johnson. In this cutting-edge episode, Lucas Aoun sits down with the renowned Dr. Bankole Johnson to explore two of the most fascinating and underexplored frontiers in regenerative medicine — regenerative protein arrays and MUSE stem cells. Dr. Johnson unpacks the science behind how regenerative protein arrays are being leveraged to orchestrate cellular repair, signal tissue regeneration, and potentially redefine recovery at a biological level. The conversation dives deep into how these protein networks communicate within the body and what this means for the future of healing, longevity, and performance optimization. Relevant links:Official Website: https://genesisregenerative.com/ Learn more about RPA here: www.genesisregenerative.com/relgeanChapters:00:00 Introduction and Guest Introduction00:55 Personal Journey into Health and Optimization02:14 Principles of Naturopathic and Holistic Medicine03:52 Core Principles: Do No Harm and Individualized Care06:28 Focus on Gut Health and Its Central Role08:14 Evolution of Gut Health Strategies in Recent Years10:02 Food Intolerance Testing and Its Significance11:46 Understanding IgG vs IgE Food Reactions13:49 Genetics, Ethnicity, and Food Intolerances15:27 Practical Use of Food Intolerance Tests19:25 Personal Insights from Food Testing22:10 Common Pitfalls in Health Optimization24:44 The Role of Hormones and Foundation of Health27:36 High Effort Strategies and Their Impact30:50 Blood Work Analysis and Functional Medicine44:08 Thyroid Function and Its Impact on Health49:52 Holistic Principles: Body's Self-Regulation and Healing52:07 Practical Advice for Health Optimization52:49 Connecting with Dr. Alex Orton and Final ThoughtsDisclaimer:The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy for more information.
Key account management (KAM) isn't merely a sales function—it's a transformative business model that bridges organizations with their most valuable customers. Too often misunderstood or underleveraged, KAM has the potential to drive deep strategic value and foster long-term growth. In this episode of Sales Reinvented, Mark Davies and I unpack the essentials of effective key account management, the common pitfalls organizations face, and the concrete strategies for building world-class account relationships. Mark, chairman of the Association of Key Account Management, visiting fellow at Cranfield, and founder of Value Matters. With deep expertise as both a buyer and seller, including leadership roles at BP and in the pharmaceutical industry, Mark brings a wealth of insight into what sets key account management apart from traditional sales approaches. Outline of This Episode [00:00] Who are key account customers? [03:55] Challenges in key account management [07:26] Understanding the customer's big picture [10:25] Talking to customers at different levels [16:14] Building a customer-focused strategy plan [22:18] Unlocking growth through collaboration Avoiding Common Mistakes in Key Account Management One of the biggest traps companies fall into is believing that training alone can transform their KAM results. Mark cautions that KAM is more than just the key account manager, it's a company-wide mindset and approach, not a solo endeavor. A critical organizational misstep is continuing to reward key account managers on short-term sales targets while expecting them to deliver multi-year account growth. Metric systems must evolve to reflect longer-term, value-driven objectives, not just monthly or quarterly transaction goals. What Makes an Effective Key Account Plan? A living KAM plan is not just a glorified document; it's a dynamic framework for strategy, internal alignment, and customer engagement. Mark recommends structuring plans around five pillars: capturing value insights, developing tailored value propositions, defining account strategies, securing internal buy-in (the "internal pitch"), and ensuring robust value delivery backed by measurable outcomes. Regular leadership reviews and organizational engagement are essential to keep the plan actionable and relevant—a "set it and forget it" approach simply won't work. Top Do's and Don'ts for Key Account Management Key account management is ultimately about building trust, understanding, and value for both parties. With strategic leadership, disciplined processes, and a focus on genuine customer partnership, KAM can elevate selling from transactional to transformational. Here are Mark's dos: Do treat KAM as a distinct business model and change process Do start with a focused set of accounts Do engage the broader organization And here are his don'ts: Don't measure KAMs solely on short-term sales Don't overload them with too many accounts Don't neglect the fundamentals of value-based selling Mark shares a powerful example of when key account management works from a business that, after implementing collaborative KAM strategies across its merged business units, unlocked organic growth so significant that they struggled to meet the surge in demand. Mark's story illustrates how the right KAM process can transform relationships and drive sustainable business results. Connect with Mark Davies Mark Davies on LinkedIn Connect With Paul Watts LinkedIn Twitter Subscribe to SALES REINVENTED Audio Production and Show Notes by PODCAST FAST TRACK https://www.podcastfasttrack.com
In people with severe depression and cognitive decline, brain glucose metabolism has been shown in some studies to decline measurably. Ketone metabolism, by contrast, appears relatively preserved. That single observation is reshaping how researchers think about psychiatric illness.In this episode, Dominic D'Agostino sits down with Bret Scher, a cardiologist who pivoted to metabolic psychiatry and now leads clinical education and content for Metabolic Mind at the Baszucki Group. Dr. Scher brings a rare dual perspective: deep training in conventional cardiology paired with three years embedded in the research and clinical practice exploring metabolic approaches in psychiatry.The conversation covers brain energy dysfunction as a potential unifying mechanism across psychiatric disorders, the preserved ketone metabolism documented in work by researchers like Stephen Cunnane, the recently published Delphi consensus paper on metabolic psychiatry, why four-week randomized trials may be inadequate for nutritional interventions, and the case for future diagnostic categories like metabolic depression and metabolic bipolar disorder.Questions Answered in This Episode:Are we underestimating brain energy dysfunction as a potential unifying mechanism across psychiatric disorders?What are the two biggest clinical mistakes patients make when starting ketogenic therapy for mental illness?Should ketogenic therapy ever be positioned as a first-line intervention for psychiatric disorders?What is the single biggest bottleneck preventing wider clinical adoption of ketogenic therapy?What has been the most unexpected challenge in moving metabolic psychiatry into the mainstream?What does precision, personalized, prescriptive ketone metabolic therapy actually look like in clinical practice?This conversation reframes psychiatric illness as a question of brain energy alongside neurotransmitter signaling and other biological mechanisms, with implications for how the next decade of research and clinical training will unfold.Join the Live Q&A with Dr. Bret Scher. Bring your questions directly to Dr. Scher on May 29 at 10:00 a.m. Pacific / 1:00 p.m. Eastern. Register here.Where to Find Dr. Bret Scher Online:Metabolic MindCoalition for Metabolic HealthSpecial thanks to the sponsors of this episode:✅ Toups and Co – Get 15% off your first order with code METABOLIC here.✅ iRestore – Get a huge discount on the Elite and the Illumina bundle with the code LINK here.✅ MudWtr – Get up to 43% off + free shipping and a free rechargeable frother with code METABOLICLINK here.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
Stop Rushing Contracts and Start Protecting Your Work A seven second truth most creatives feel You get an exciting client email, then the contract arrives and your chest tightens as legal pages show up. A deeper question we rarely say out loud What would change if contracts felt like clarity instead of confusion in your creative business? Meet the guest who makes legal feel human Mica McCook sits down with Rob Finkelstein, a lawyer, pastry chef, and food blogger who helps creatives understand contracts, licensing, and business protection in a simple way. What this episode gently unpacks This conversation opens the door to the hidden world behind creative work. You learn how contracts define ownership of your images, why licensing matters more than most realize, and how influencer-style agreements often miss the mark for photographers. Rob explains how negotiation is a normal part of business and not a risk to your opportunity. You also hear why forming an LLC protects your personal life from business risk and how even “small” contract details like legal jurisdiction can shape real outcomes. The episode also touches on supplier diversity certifications and how they can open doors for creatives from underrepresented communities. What you can take into your own business You will walk away understanding that asking questions is part of professional work. You will feel more confident reading contracts line by line. You will see that protecting your work and income is not complicated when you understand the basics. You will also feel encouraged to treat your creative path like a real business with structure and intention. A final reminder to carry with you You are allowed to slow down before signing. You are allowed to ask. You are allowed to understand every word before you agree. Your creativity deserves that level of care.
To learn more about Breakthrough Academy, click here: https://trybta.com/EP272 Grab a copy of Megan's OWN Your Contracts QuickStart Guide: https://meganshapiro.kit.com/590f12c899Check out Megan's Negotiation Style Quiz: https://meganshapiro.kit.com/81045b49f1If you've thought about using AI to make the process of drafting, reading, and negotiating contracts easier, you're not alone.But according to today's guest, relying on AI for your contracts could be a costly mistake. Because the reality is: AI is only as good as the knowledge of the user.In this week's episode of Contractor Evolution, we sit down with construction lawyer Megan Shapiro to break down what's actually happening inside the agreements you're signing, and how to negotiate them in a way that makes you more profit, keeps you out of legal trouble and empowers you to safely incorporate AI where appropriate.You'll learn:The biggest contract clauses that quietly kill your marginsHow to spot red flags (before they cost you)A simple three part framework to review and negotiate contracts with confidenceWhere it's appropriate to use AI in your negotiations (and where it can trigger a legal disaster)00:00-Intro05:49-Trade Contractor Contract Rights 07:22-Risks and Common Pitfalls 10:16-Introducing The OWN Framework 17:13-Weighing Specific Contract Provisions 29:29-Change Orders And Delays 39:27-Healthy Professional Negotiation Strategies 47:53-AI In Contract Management
Martyn's process. Dealing with common trader pitfalls. Defining steps and methods for avoiding over-fitting."Opt My Strategy" the Robustness Testing Application built by Martyn Tinsley. Up to 25% off for Algo Advantage Subscribers!! https://www.algoadvantage.io/toolboxMartyn's paper on his new technique, "Walk Forward Correlation A Diagnostic for Over-Fitting and Structural Edge in Trading Strategy Optimisation": Our courses, community & toolbox: https://algoadvantage.ioContents:00:00 Introduction and Setup02:02 Martyn's Trading Journey12:07 Transition to Algorithmic Trading20:02 Common Pitfalls in Trading30:11 Developing Robust Trading Strategies31:55 Understanding Parameter Optimization and Performance Metrics39:43 The Impact of Economic News on Trading Strategies44:38 Identifying the True Edge of Trading Strategies52:05 Noise Reduction Techniques in Algorithmic Trading01:01:49 Research Phase vs. Optimization in Trading Strategies01:07:33 Reassessing Trading Strategies01:08:00 The Importance of Statistical Significance01:09:00 Understanding Sample Size in Trading01:10:00 Methodology for Backtesting Strategies01:11:59 The Role of Edge in Trading Strategies01:15:03 Randomness vs. Genuine Edge01:17:59 Long-Term Performance and Sample Size01:19:52 Confidence in Trading Results01:22:00 Increasing Sample Size for Better Results01:24:01 Testing Across Multiple Assets01:26:04 Optimizing Across Timeframes01:30:01 Generalizing Strategies Across Markets01:31:57 Diversification in Trading Strategies01:35:05 Final Thoughts on Strategy Optimization
Getting an NDA signed shouldn't take weeks. If your CRO needs more than 48 hours to start the paperwork, your project timeline is already moving in the wrong direction.Ron Najafi knows what rigorous analytical work actually looks like under pressure. As founder and CEO of Emery Pharma, he led the investigation that identified NDMA as a degradation product of ranitidine — findings the FDA formally validated and that reshaped how the industry approaches nitrosamine risk assessment. In Part 2, he moves from that scientific foundation into the operational questions that determine whether a CRO partnership accelerates your program or quietly slows it down.If you haven't heard Part 1, it covers Ron's career arc and the technical details of nitrosamine contamination in pharmaceutical development. This episode stands on its own for anyone focused on CRO selection, bioanalytical strategy, and what three decades of building analytical companies actually teaches you.Topics discussed:How to tell if a CRO's workflow is robust—or just rigid (05:51)The importance of method validation and product stability testing (07:27)Managing expectations and trust-building in client relationships (08:29)Entrepreneurial lessons: raising capital, team-building, and finding the right partners (10:00)The hidden costs of public vs. private biotech ventures (12:31)Reducing bioanalytical costs in biologics through mass spectrometry (13:23)The future of analytical workflows and personalized medicine (14:48)Smart insight:In biotech, success isn't just about the science—it's about strategic discipline. Ron emphasizes a few hard-earned principles: raise more capital than you think you'll need, don't fixate on valuation, and invest in smart, creative talent. Just as important, real value is unlocked through strong partnerships and the ability to manage collaborations and acquisitions with intention.If this topic resonates with you, here are a few related episodes on building strong CMC foundations and avoiding costly development mistakes:Episodes 231 - 232: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri KornmannEpisodes 203 - 204: Mastering CRO Selection: Essential Questions for CMC Analytical Development with Daniel GalbraithEpisodes 199 - 200: Mastering Quality by Design: From Product Failures to Commercial Success in Biologics CMC DevelopmentEpisodes 189 - 190: Why Smart Biotech Founders Plan CMC First (While Competitors Burn Cash Later)Episodes 139 - 140: Regulatory Secrets Revealed: Why Your CMC Strategy Could Make or Break Your Biotech Startup with Rivka ZaibelEpisodes 57 - 58: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls with Matthias MüllnerEpisodes 23 - 24: Strategies for Success: Master CMC Development with Gene LeeConnect with Ron Najafi:LinkedIn: www.linkedin.com/in/ronnajafiEmery Pharma: www.emerypharma.comSupport the show
When drug safety fails, patients and entire markets pay the price. Understanding your CMC isn't just compliance — it's the line between therapeutic promise and product recall.Ron Najafi has lived that reality firsthand. As founder of NovaBay Pharmaceuticals and Emery Pharma, he spent decades building companies at the intersection of analytical chemistry and drug development. His investigation into nitrosamine contamination in ranitidine — which led the FDA to formally validate Emery Pharma's findings — remains one of the most consequential episodes in recent pharmaceutical quality history.In Part 1, Ron traces the scientific and entrepreneurial path that led him there, and shares what CMC teams working in drug development need to understand about impurity risk before it becomes a regulatory crisis.Episode highlights:Early academic experiences and inspirations that Ron Najafi to a science career (05:46)Challenges and milestones in building companies like CP Lab Safety and NovaBay Pharmaceuticals (07:59)The invention and impact of the ECO Funnel® on lab safety and environmental responsibility (12:01)The formation of Emery Pharma following industry setbacks and lessons in adaptation (17:03)The fundamentals of impurity risk analysis, especially nitrosamine contamination in pharmaceuticals (20:56)The ranitidine (Zantac) NDMA discovery, its investigation, and consequences for drug regulation (23:33)Common sources of nitrosamine and practical advice for bioprocess risk management (27:51)Differences in impurity risk between small molecule and biologic drug processes (28:03)The necessity and regulatory expectation of impurity and leachable/extractable analysis (30:07)Smart insight:One of Ron's clients conducted a superficial nitrosamine risk assessment, proceeded to manufacturing, and spent approximately $6 million producing three batches. At final FDA-required testing, NDMA came back at 11,000 nanograms per pill against an acceptable daily intake limit of 96 nanograms. The batches were unusable.A thorough risk assessment run earlier would have cost a fraction of that. If you are developing a drug with secondary or tertiary amines in your process and have not yet conducted a formal nitrosamine risk assessment, that is the one action to take after listening to this episode.If this topic resonates with you, here are a few related episodes on building strong CMC foundations and avoiding costly development mistakes:Episodes 231 - 232: From IND to BLA: The Biologics CMC Decisions That Determine Regulatory Success with Henri KornmannEpisodes 203 - 204: Mastering CRO Selection: Essential Questions for CMC Analytical Development with Daniel GalbraithEpisodes 199 - 200: Mastering Quality by Design: From Product Failures to Commercial Success in Biologics CMC DevelopmentEpisodes 189 - 190: Why Smart Biotech Founders Plan CMC First (While Competitors Burn Cash Later)Episodes 57 - 58: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls with Matthias MüllnerEpisodes 23 - 24: Strategies for Success: Master CMC Development with Gene LeeConnect with Ron Najafi:LinkedIn: www.linkedin.com/in/ronnajafiEmery Pharma: www.emerypharma.comSupport the show
Most people know that interstate moving is very different from local relocations, but unless you've done it, few are as prepared as they need to be. Experts are revealing the problems that plague most cross-state projects - and how to avoid them.Info: https://www.truefriendsmovingcompany.com/nashville/long-distance-moving/ True Friends Moving Company City: Nashville Address: 700 East Old Hickory Blvd Website: https://www.truefriendsmovingcompany.com/
In this episode of The Consumer Finance Podcast, Chris Willis is joined by colleagues Joe DeFazio, Brad Knapp, and Punit Marwaha for a practical introduction to consumer bankruptcy from the creditor's perspective. The panel walks through the core bankruptcy chapters that consumer financial services companies encounter most often and explains how the automatic stay, co-debtor stay, and discharge injunction operate in real-world servicing and collection environments. They discuss treatment of secured and unsecured debts, reaffirmation agreements, and hot-button issues like the dischargeability of qualified education loans. The conversation also highlights common traps for mortgage servicers, auto lenders, and unsecured creditors, including repossessions, garnishments, foreclosure timing, and plan objections, as well as preference actions and clawbacks. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
When a single mismanaged tech transfer threatens an entire development program, pressure on CMC leaders and bioprocess teams is intense. The truth? Tech transfers aren't a black box. They're complex, but solvable with the right mindset and playbook.In this episode, David Brühlmann explores the practical side of tech transfer and scale-up within the biotech industry. With more than 15 years of experience, he shares personal stories and industry-tested frameworks that help demystify the complexities of transferring technologies between sites or organizations. Instead of focusing solely on technical details, he emphasizes the crucial human and organizational factors that often decide project success or failure.Key topics discussed:How mapping and managing stakeholders can resolve hidden issues and accelerate projects (01:55)Case studies highlighting the importance of environmental factors — like light exposure — in process performance and troubleshooting (05:50)A mass transfer checklist for bioprocess scale-up, with specific focus on equipment-related parameters (07:09)The build vs. outsource dilemma: how to choose what to keep in-house and what to partner out, depending on company strategy and project phase (08:05)A 12-week tech transfer preparation protocol, covering foundations, risk mitigation, and execution readiness (10:16)Lessons on leadership, prioritization, and effective delegation to avoid personal and organizational bottlenecks (13:28)Whether you're overseeing a complex CMC program, navigating CDMO relationships, or planning your next scale-up, this episode offers concrete steps to cut through confusion and deliver results.If you're interested in the ideas discussed, here are some of the guests David referenced in this episode.Episodes 91 - 92: Mass Transfer Secrets: Mastering Bubbles and kLa from Bench to Large-Scale Production with Lars Puiman & Rik VolgerEpisodes 79 - 80: Think Before You Build: Holistic Approaches to Biotech Facility Design with Alfredo Martínez MogarraEpisodes 57 - 58: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls with Matthias MüllnerEpisodes 23 - 24: Strategies for Success: Master CMC Development with Gene LeeSupport the show
Most marathon plans treat strength training like an afterthought.Most nutrition guides ignore the fact you're also trying to keep weight on a bar.This one's different.JB sits down with Tom McClure, OMNIA's Head of Performance Nutrition and a hybrid athlete who actually does this stuff, to go through everything that matters when you're chasing 26.2 miles without watching your strength fall apart.Tom pulls back the curtain on his own London Marathon prep - what's worked, what hasn't, and the honest reality of fuelling hard training blocks when life doesn't slow down for you.Find out more about OMNIA's CoachingHybrid Training Guide (100% FREE)
What if the hidden cost of your bioprocess lies not in the technology, but in what you don't document?Too often, biotech teams discover too late that their “proven” process is just an illusion, propped up by undocumented tricks and missing critical parameters. In this episode, David Brühlmann strips down the assumptions behind scale-up and tech transfer, exposing the silent risks that threaten CMC milestones and market launches alike. After 15 years guiding biotech projects from bench to clinic, he's felt the pain of process gaps, regulatory curveballs, and million-dollar mistakes. Here, he turns that experience into a tactical guide designed to save you from the same pitfalls.In this episode, you'll learn about:The 6-pillar approach to turning tech transfer into a managed process, rather than a gamble (03:09)Why mass transfer physics and factors like kLA are critical—and how they can make or break a process at scale (05:12)The importance of analytical comparability, including the common blind spots in sampling plans and method validation (07:19)Establishing a solid Quality by Design (QbD) foundation and defining critical quality attributes before transfer, not after failures (08:33)Stakeholder management and why non-technical challenges often derail projects (with more on this in Part 2) (10:09)Evaluating CDMO partners: What selection criteria really matter for long-term success and risk mitigation (11:03)Strategic decision-making: Building core capabilities versus outsourcing, and how to avoid unnecessary costs and delays (12:22)This episode sets the stage for Part 2, where David Brühlmann will share practical stories and detailed frameworks for real-world implementation. If you manage bioprocess scale-up, tech transfer, or CMC development, you'll find plenty of actionable insights to apply in your own work.If you're interested in the ideas discussed, here are some of the guests David referenced in this episode.Episodes 91 - 92: Mass Transfer Secrets: Mastering Bubbles and kLa from Bench to Large-Scale Production with Lars Puiman & Rik VolgerEpisodes 79 - 80: Think Before You Build: Holistic Approaches to Biotech Facility Design with Alfredo Martínez MogarraEpisodes 57 - 58: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls with Matthias MüllnerEpisodes 23 - 24: Strategies for Success: Master CMC Development with Gene LeeSupport the show
Episode Summary In this episode of Practical Cybersecurity, we dive into the complex world of HITRUST certification. Often called the "gold standard" for healthcare security, HITRUST can be a daunting mountain to climb for small and large organizations alike. Jen Stone and experts Peter Briel (Privaxi) and Lee Pierce (SecurityMetrics) break down why scoping is your best friend, why screenshots aren't enough, and why you should never try to "button things down" before talking to an expert.Key Discussion Points:What is HITRUST? Unlike HIPAA, which lacks a formal certification, HITRUST integrates multiple standards (NIST, ISO, etc.) into a "beefy" framework. It provides a definitive answer to security and compliance inquiries in the healthcare space.The Three Levels of HITRUST:E1: The entry-level, static 44-control assessment.I1: The "leading practices" assessment with roughly 180+ controls.R2: The risk-based, "gold standard" that requires heavy factoring and scoping.The "House Alarm" Analogy: You can't protect a house if you don't know how many windows and doors it has. Asset management is the foundation of security; if you don't know what hardware and software you have, you can't secure the perimeter.Common Pitfalls in Certification:Overscoping: Fear often leads companies to include too much in their audit, driving up costs and timelines unnecessarily.Weak Evidence: Assessors need a "story," not just a screenshot. Evidence must be consistent, repeatable, and include clear date/time stamps.The "Never Happened" Trap: Even if you haven't fired anyone or had a breach in years, you must have a documented, tested process for how you would handle those events.The Importance of Readiness: The "separation of duties" means your auditor can't also be your consultant. Engaging a readiness team early helps you build the foundation correctly the first time, rather than tearing down finished work to meet compliance standards later.Expert Tips for Success"Don't build it and then do readiness afterwards." — Lee Pierce Start the conversation while you are still building your solutions or migrating to the cloud to ensure encryption and segmentation meet the standard from day one."Don't rush... it's not a check-the-box exercise." — Peter Briel Focus on building a solid foundation. HITRUST isn't just about the certificate; it's about actually protecting the environment.Resources MentionedSecurity Metrics Website: Visit for a quick HITRUST cost assessment and to connect with the readiness and audit teams. https://www.securitymetrics.com/hitrustFactoring Tools: Resources to help determine whether you need an E1, I1, or R2 assessment.A note from Jen: We built Practical Cybersecurity because we were tired of the fear-mongering in this industry. Security shouldn't be a secret club.If you're trying to figure out PCI compliance or need a pen test, my team at SecurityMetrics can help you out: https://www.securitymetrics.com/contact/lets-get-you-to-the-right-place But if you just want to learn how to protect yourself for free, start here: https://academy.securitymetrics.com/
Hey Nonprofits is the ONLY podcast specifically focused on event fundraising and auction strategy — because someone has to stand up for the gala. This is Part 1 of the Timed to Perfection Series — a 6-part webinar series built entirely around the #1 question we get from nonprofit event fundraisers: "How do we nail the timing of our event?" In this episode, two of the most in-demand fundraising auctioneers in the country — Jordan Campbell (Atlanta) and Chris Hensley (Chicago) — break down everything that happens before, during, and after your gala that determines how much money you raise. Spoiler: It's not the 18 minutes on stage. It's the 18 weeks that led up to it.
What if every impression you made at work was as powerful as your first? In this episode of Predictable B2B Success, Vinay Koshy speaks with serial entrepreneur, sales leader, and author Glenn Poulos. Glenn's three-decade journey from technical sales rep to building and selling companies is packed with real-world wisdom. He reveals why a thriving sales culture is not about luck, but about structure, core values, and the courage to leap, even when fear is loud. Hear the story behind his book, “Never Sit in the Lobby,” and how the lessons he began jotting down in 1985 became actionable strategies anyone can use to win clients and build lasting relationships. Discover Glenn's approach to assembling high-performing sales teams, why onboarding and core value buy-in are non-negotiable, and how simple shifts in communication can transform results and reputations. Whether you're a leader struggling with turnover, a founder ready to scale, or fascinated by what makes top sales organizations tick, this episode is filled with candid stories, practical frameworks, and memorable tactics you'll want to try starting today. Some topics we explore in this episode include: Glenn Poulos's Sales and Entrepreneurial Journey: His career path, company exits, and industry moves.Why and How He Wrote "Never Sit in the Lobby": The motivation and process behind the book.Risk-Taking and Overcoming Fear in Business: Practical frameworks for pushing past fear and launching ventures.Building Customer-Centric Companies: Operationalizing exceptional customer service.Sales Team Structure & Metrics: Organizing sales departments, roles, and compensation.Core Values in Hiring and Culture: Identifying and maintaining strong team cultures and values.Common Pitfalls in Sales Organizations: Mistakes like unclear roles and poor onboarding.Strengthening Customer Relationships: Methods to be a consistent pleasure to work with.Communication and Active Listening: Why rapport and listening trump talking in sales.Transforming Teams into Revenue Machines: Systematic approaches for turning sales teams into high-performing, aligned organizations.And much, much more...
content type Interview primary goal Educational summary In this episode, Mitch Beinhaker interviews Mark about business exit strategies, valuation, and innovative ways to maximize business value and cash out tax-free. They discuss the importance of succession planning, structuring deals, and leveraging capital to grow and sell businesses more profitably. keywords business exit, valuation, succession planning, business growth, tax-free cash out, private equity, business group, capital deployment, M&A, business strategy key topics Business exit strategies and valuation The Double and Keep It Framework Using capital to grow business groups Reducing fees and taxes in business sales The importance of succession planning and owner transition guest name Mark Titles Revolutionizing Business Exits: The Double and Keep It Framework How to Double Your Business Value Without Dilution or Debt sound bites "COVID and cancer changed my perspective on life and business." "Cleaning up books and processes can significantly boost valuation." "Helping business owners keep more and sell smarter is our goal." Chapters 00:00 Introduction and Overview of the Conversation 01:23 Marc's Journey: From Sales to Business Growth 03:43 The Impact of COVID-19 on Business and Personal Life 06:44 Facing Cancer: A Life-Changing Diagnosis 12:33 The Promise to His Son and the Birth of a New Mission 16:44 Innovative Solutions for Business Owners 20:39 The Unique Approach to Business Grouping and Valuation 27:25 Building a Bigger Group: The Power of Capital 30:03 Understanding Market Dynamics and Buyer Interests 32:01 Identifying Opportunities in Various Industries 34:59 Maximizing Business Value: Strategies for Owners 38:47 Common Pitfalls in Business Valuation 44:17 Leveraging Technology for Business Growth 48:45 Disrupting Traditional Business Valuation Models resources acquisitionsforyou.com - https://acquisitionsforyou.com The Secrets to 10Xing Your Business and Cashing Out Tax Free (Book) - https://www.amazon.com/dp/B0XXXXXX Mitch Beinhaker (LinkedIn) - https://linkedin.com/in/mitchbeinhaker
In this engaging interview, Chloe Varnfield shares her journey in digital marketing, her experiences with mistakes and lessons learned, and insights into managing client relationships and the evolving AI landscape. Perfect for marketers looking to grow and learn from real-world scenarios.Key topicsCommon PPC mistakes and how to avoid themThe importance of default settings and account auditsManaging client relationships during campaign crisesThe impact of AI on digital marketing strategiesLessons learned from real-world marketing errorsChapters00:00 Introduction and Personal Updates06:20 Mistakes in Digital Marketing: Learning from F-ups14:02 Navigating Campaign Challenges and Client Communication20:29 Building a Toolkit for Success23:13 The Importance of Community and Support26:04 Learning from Mistakes in Marketing29:37 Common Pitfalls in Account Management33:08 Navigating the AI Revolution in Marketing34:47 Celebrating Successes and Personal Growth40:57 Outro.mp3Follow Chloe on LinkedIn PPC Live The Podcast features weekly conversations with paid search experts sharing their experiences, challenges, and triumphs in the ever-changing digital marketing landscape.Go to PPC Live for early bird ticket saleJoin us on SlackSubscribe to our Newsletter
Mauro Sambati, Partner – Gianni & Origoni Donato Romano, Partner – Gianni & Origoni Italy remains one of Europe's most attractive markets for foreign investment. But cross-border deals in Italy are shaped by regulatory scrutiny, strict labor laws, and unique cultural dynamics that many investors underestimate. In this episode, Mauro Sambati and Donato Romano, Partners at Gianni & Origoni, explain what it truly takes to structure and close successful transactions in Italy. What You'll Learn in This Episode Why Golden Power must be structured as a condition precedent before closing How strict Italian labor laws impact asset deals and post-closing restructuring The differences in negotiation styles between US, UK, Japanese, and Korean buyers How minority governance protections are typically structured in Italy The evolution from closing accounts to lockbox pricing mechanisms This episode offers a practical perspective for M&A leaders navigating complex decisions where clarity and conviction matter as much as valuation. Listen to the full episode to learn how strategic focus can define billion-dollar outcomes. _____________________ If you're structuring a cross-border deal in Europe, the Hub has practitioner-built playbooks and AI-assisted deal guidance to help you navigate regulatory clearance sequencing, minority governance, and founder transition dynamics. Become an M&A Scientist at www.mascience.com/membership _____________________ This episode is also sponsored by DealRoom DealRoom's State of M&A Report gives you data to back up your M&A priorities. The State of M&A Report reveals the gap between what teams think matters and where the real bottlenecks are. Download it now to get expert insights: https://hubs.ly/Q03ZxRvD0 ____________________ Episode Chapters [00:02:59] Guest Backgrounds & Italian Legal Market – Introduction to the partners at GOP and how Italy's full-service law firms support cross-border buyers. [00:08:47] Lessons from Early Cross-Border Deals – Why negotiation strategy, communication, and cultural awareness matter more than technical drafting. [00:11:03] Golden Power Regulations Explained – How Italy's FDI regime works, what sectors trigger review, and how geopolitical shifts expanded scrutiny. [00:17:40] Managing Regulatory Risk & Deal Timing – Practical steps for foreign buyers to navigate filings, conditions precedent, and approval timelines. [00:21:54] Cultural Differences in Buyer Behavior – How Japanese, Korean, UK, and US acquirers differ in speed, hierarchy, and decision-making. [00:29:46] Common Pitfalls for US Buyers in Italy – Employment law constraints, founder influence, and the risks of moving too fast post-acquisition. [00:35:40] Deal Sourcing in Italy – The shift from investment bank–led processes to lawyer-driven origination and evolving private equity activity. [00:42:20] Lockbox vs. Closing Accounts – How Italian deal structures have evolved, why private equity favors lockbox, and the mechanics behind each method. [00:48:50] Earnouts & Governance Tensions – Structuring short-term earnouts, aligning incentives, and balancing control with seller protections. [00:57:35] Labor Law & Retention Realities – Why layoffs are complex in Italy, union consultation requirements, and the cultural importance of employee continuity. [01:03:08] The Craziest Thing in M&A – An Italian founder let employees vote on the preferred buyer, choosing cultural fit over a higher private equity offer.
How solid is your CMC foundation—and what happens if it cracks under pressure?David Brühlmann welcomes Henri Kornmann, former Head of Biologics Innovation Centre at Ferring Pharmaceuticals. From junior CMC scientist at Merck to leading Ferring Pharmaceuticals' first gene therapy approval for bladder cancer, Henri has moved repeatedly between CMC development, GMP manufacturing, and due diligence across some of the industry's most complex programs.His “house building” approach demystifies CMC's complexity, showing why early diligence paired with regulatory fluency and scientific insight pays dividends for years.Tune in to hear Henri's practical wisdom distilled through real-world analogies:Building a strong CMC foundation in early phases and why later fixes can be costly or impossible (02:45)Scaling up: supplying Phase 3 with the final commercial process, including robustness and supply chain strategies such as dual sourcing critical raw materials (03:23)Process validation explained: FDA's three stages, from control strategy justification to continued verification (05:15)Process Performance Qualification (PPQ): what it is, how many batches are needed, and optimizing timing (07:43)Handling lifecycle changes: maintaining process control, adapting to deviations, and improving systems after regulatory approval (09:34)Managing teams, stakeholders, and cross-functional collaboration in CMC programs (11:49)Importance of good project management, access to scientific expertise, and interpreting guidelines for your specific program (12:27)The “half scientist, half lawyer” analogy for mastering both technical and regulatory aspects (15:08)Smart insight:Never underestimate CMC. If you do, you will pay for it later.If this topic resonates with you, here are a few related episodes where we dive deeper into building strong CMC foundations and avoiding costly development mistakes:Episodes 199 - 200: Mastering Quality by Design: From Product Failures to Commercial Success in Biologics CMC DevelopmentEpisodes 189 - 190: Why Smart Biotech Founders Plan CMC First (While Competitors Burn Cash Later)Episodes 23 - 24: Strategies for Success: Master CMC Development with Gene LeeEpisodes 57 - 58: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls with Matthias MüllnerConnect with Henri Kornmann:LinkedIn: www.linkedin.com/in/henri-kornmann-9b6869Next step:Need fast CMC guidance? → Get rapid CMC decision support hereSupport the show
You've lived in moments where one emotional decision can cost you a stack of chips… or three strokes in 90 seconds. And that's why this conversation with Alex Huang hits so hard. Alex breaks down how poker "tilt" and golf blow-up holes are the same problem in different clothing: impulsivity, entitlement, and emotion hijacking decision-making. We talk long-run thinking, why variance (aka luck) doesn't excuse bad process, and how numbers can act like "bowling bumpers" that keep you from derailing when your expectations outpace reality. You'll also hear Alex's best frameworks for talking players off the ledge after a mistake, why elite players obsess over reflection (even after shooting low), and the single message he'd put on a billboard every golfer would see: process, not results. In this episode, you'll learn: Why impulsivity in golf is just "tilt" with a scorecard How to think in "the long run" so one hole doesn't define your round How variance + luck can still coexist with elite decision-making Why 15-foot putts deserve realistic expectations (and calmer emotions) How data creates objectivity without crushing feel-based players Where ego and entitlement bleed strokes (especially par 5s + short par 4s) How elite players reflect, catalog "feels," and build resilient performance Get your pencils ready and start listening. Apply for 1-1 High-Performance Hypnotherapy and Mindset Coaching: Click here to apply to work with me. The 90-Day Golf Identity Upgrade Accelerator: This is a private 3-month coaching container designed to help serious golfers rapidly upgrade their beliefs, rewire their golf identity, and accelerate lower scores through deep subconscious transformation — not surface-level tactics. Click here to learn more and DM me "identity upgrade on Instagram (@thepaulsalter) to learn more. More About Alex Huang Alex is the COO of DECADE Golf. He works with several dozen LPGA / EPSON Tour players as well as many of the Top 10 college programs in both Men's and Women's golf. He specializes in distilling complicated golf data and ideas into simpler heuristics and concepts. You can follow Alex on Instagram here: @alexhuanggolf Play to Your Potential On (and Off) the Course Schedule a Mindset Coaching Discovery Call Subscribe to the More Pars than Bogeys Newsletter Download my "Play Your Best Round" free hypnosis audio recording. High-Performance Hypnotherapy and Mindset Coaching Paul Salter - known as The Golf Hypnotherapist - is a High-Performance Hypnotherapist and Mindset Coach who leverages hypnosis and powerful subconscious reprogramming techniques to help golfers of all ages and skill levels overcome the mental hazards of their minds so they can shoot lower scores and play to their potential. He has over 16 years of coaching experience working with high performers in various industries, helping them get unstuck, out of their own way, and unlock their full potential. Click here to learn more about how high-performance hypnotherapy and mindset coaching can help you get out of your own way and play to your potential on (and off) the course. Instagram: @thepaulsalter Key Takeaways: Tilt isn't an emotion problem—it's a decision problem that emotions accelerate. The long-run mindset protects you from chasing: one bad swing doesn't require a heroic response. Variance is real: a good decision can produce a bad outcome (divots, bounces, gusts) and still be the right play. Numbers act like bowling bumpers—keeping you from going so aggressive you create doubles and triples. "Should" is a red-flag word: entitlement (par 5s, wedges, short par 4s) is where blow-ups are born. When emotions spike, win the next moment: get hyper-specific on the target and stack micro-wins (GIR, 10% rule, speed). Elite players invest in reflection and documentation—especially when playing well—so they can return to what works faster. Key Quotes: "One catastrophic decision or one downward spiral where you're kind of chasing a previously bad decision — as we used in poker the term tilt — that can lead to your demise. You blink, you make a triple bogey because you got a bit greedy or a bit thoughtless or reckless with the strategy." "Just because you lost your pot going all in with aces pre-flop does not mean in hindsight you now look back and say, I should have folded. Much the same way with golf… you pick a good target, you make a committed swing… maybe you get unlucky and you wind up in a divot." "If I gave you a full deck of cards and I asked you to draw a diamond out of it and you drew a spade, would you be ticked off? No, right. But then how many times have they stood over a 14 or 15 foot putt upset that they didn't make it?" "You can't control where your shot ends up within its shot pattern. You can't control the bounces you're going to get. But what you can control is making a committed swing at your target and dealing with the results." Time Stamps: 00:00: The Cost of Impulsivity in Poker and Golf 02:50: Long-Term Thinking in Competitive Environments 05:40: Defining and Developing Resiliency 08:39: The Role of Data in Decision Making 11:33: Balancing Numbers and Intuition 14:44: Patience and Preparation in Golf 17:27: Common Pitfalls and Mindset Traps 20:36: The Importance of Reflection and Process 23:12: Curiosity as a Catalyst for Growth 26:20: Building a Supportive Network 29:15: Mental Game Strategies for Golfers 32:12: Resetting After Mistakes 35:16: The Power of Objectivity 38:02: Investing in Mindset and Reflection 40:49: Final Thoughts on Process Over Results
Seventy percent of FDA Complete Response Letters have a CMC root cause. Most of those failures trace back to decisions made years earlier. Decisions that felt minor at the time and proved impossible to fix later.Henri Kornmann has spent two decades making those decisions the right way. From junior CMC scientist at Merck to leading Ferring Pharmaceuticals' first gene therapy approval for bladder cancer, Henri has crossed between CMC development, GMP manufacturing, and due diligence across some of the industry's most complex programs. His conclusion: a CMC program is like building a house. Get the foundation wrong and no amount of late-stage effort will save you.In Part 1, Henri reveals the decisions that cannot be undone and how to get them right from the start.What you will learn:Evolution of cell bank technology and regulatory expectations (00:33)The impact of weak CMC foundations on late-stage failure (00:51)Lessons learned from Ferring's gene therapy approval and CMC gap analysis (06:51)FDA statistics on CMC issues in INDs and response letters (08:07)Critical early decisions: cell bank clonality and proper storage practices (10:22)The importance of comprehensive raw material documentation (12:29)Early analytical characterization and discovering molecular “funkiness” before phase trials (13:41)Supply strategy for phase 2—why stability and batch knowledge matter (14:49)Introduction to critical quality attributes (CQA), process parameters, and quality-by-design principles (15:52)Common pitfalls in CQA identification and continued process verification (17:01)Smart insight:The therapies that reach patients aren't built on heroic late-stage rescues. They're built on disciplined early decisions: the right cell bank, the right analytics, the right documentation. Henri's message is unambiguous: there are CMC mistakes you can fix later, and there are CMC mistakes you cannot. Knowing the difference is the foundation of every successful biologics program.In Part 2, Henri walks through scale-up to commercial manufacturing, process validation stages 1 through 3, post-approval control strategy, and the project management and regulatory fluency that separate successful CMC leaders from the rest.If this topic resonates with you, here are a few related episodes where we dive deeper into building strong CMC foundations and avoiding costly development mistakes:Episodes 199 - 200: Mastering Quality by Design: From Product Failures to Commercial Success in Biologics CMC DevelopmentEpisodes 189 - 190: Why Smart Biotech Founders Plan CMC First (While Competitors Burn Cash Later)Episodes 23 - 24: Strategies for Success: Master CMC Development with Gene LeeEpisodes 57 - 58: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls with Matthias MüllnerConnect with Henri Kornmann:LinkedIn: www.linkedin.com/in/henri-kornmann-9b6869Next step:Need fast CMC guidance? → Get rapid CMC decision support hereSupport the show
When Dave Mabe backtested his strategy, it outperformed his own discretionary trading — and changed how he approached everything. In this episode, we discuss gapping breakouts, expectancy, systematic trading, drawdowns, and the reality gap between backtests and live execution. A practical conversation for traders serious about building durable edge. In this episode, we explore: · How Dave got introduced to markets: From early exposure to investing through his family to actively seeking more control over his capital and moving from swing trading into day trading. · Why rules matter: The transition from discretionary decisions to systematic frameworks — and why trading without a process is a fast path to inconsistency. · Backtesting as a “superpower”: What backtesting really does for strategy development and confidence in your edge. · Reconciling backtests with real life: Practical realities of execution, slippage, and market structure — and how to build a feedback loop so your live results get closer to your imulations. · Drawdowns and mindset: How to handle periods where a strategy doesn't behave as expected, and why many traders quit in drawdowns rather than at all-time highs. · Scaling a trading business: The difference between scaling size versus scaling breadth — and why uncorrelated strategies matter. · Practical first step for systematic traders: How to start adding structure to your trading with backtesting, even if you're not a programmer. About the guest: Dave has been a professional trader and technologist for over two decades. As a former CTO of Trade-Ideas, he has unique experience at the intersection of algorithm design, real-time market data, and automated execution. Outside trading, he writes a popular daily newsletter on backtesting and systematic strategy development, and hosts the Line Your Own Pockets podcast focused on systematic approaches to markets. Links + Resources: · Link to Better Backtesting —Dave's free multi-day email course on building strategies and improving them over time. · Trade-Ideas, Amibroker, RealTest — examples of backtesting and strategy development platforms discussed in context. Sponsor of Chat With Traders Podcast: Trade The Pool: http://www.tradethepool.com Time Stamps: Please note: Exact times will vary depending on current ads. 00:00 Intro and Background 08:29 Stock Selection and Systematic Trading Rules 11:32 Position Sizing, Expectancy and Risk Management 16:50 Discovering Backtesting and First Backtests 18:40 Backtesting Principles, Sample Size and Common Pitfalls 20:34 Gradual Automation and Live Trading Implementation 22:17 Trading Journal and Reconciling Backtest vs Live 27:27 Scaling through Automation: More Trades, Better Results 29:26 Drawdowns, Psychology and Handling Setbacks 34:14 Tools, AI and Software for Backtesting and Coding 39:56 Common Trading Myths Debunked (Partials, Stops) 48:01 Getting Started: Practical Steps, Resources and Closing Trading Disclaimer: Trading in the financial markets involves a risk of loss. Podcast episodes and other content produced by Chat With Traders are for informational or educational purposes only and do not constitute trading or investment recommendations or advice. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this insightful episode of "It's the Bottom Line That Matters," host Jennifer Glass sits down with Patricia Reszetylo and Daniel McCraine to demystify the concept of cash flow forecasting for business owners who may not have a finance background. The conversation kicks off by highlighting how forecasting is, in essence, about predicting the future—much like weather forecasting, it often involves assumptions and educated guesses. Patricia Reszetylo shares her experiences with preliminary forecasting for her real estate and restaurant ventures, while Daniel McCraine offers practical advice from his own business journey, explaining how he uses simple spreadsheets and lessons from mentors to track incoming cash and anticipate shortfalls.As the discussion unfolds, the speakers cover crucial aspects that anyone can apply, from understanding the realities behind revenue predictions to leveraging historical trends and third-party data—like restaurant supply metrics—to make forecasts more realistic. Daniel McCraine and Jennifer Glass address the significance of knowing your accounting method, explaining how both accrual and cash systems influence the way future income is tracked and reported. The episode also explores the role of recurring revenue models, pointing out the ease of forecasting when you have membership or subscription-based income streams and highlighting industry patterns about customer retention. By the end, listeners are equipped with tips to avoid common forecasting pitfalls, such as overestimating income from early sales meetings or failing to factor in typical customer drop-off rates. This episode provides clear, actionable guidance and reassurance that with the right approach, cash flow forecasting doesn't have to be intimidating—even for non-finance folks.KEYWORDS: cash flow forecasting, non-finance people, revenue, business numbers, forecast accuracy, cash flow, business forecasting, commission tracking, residual income, monthly residuals, spreadsheet forecasting, sales volume, restaurant business forecasting, business plan, speculative forecasting, accrual accounting, cash accounting, accounting methods, payment terms, unpaid invoices, recurring revenue, subscriptions, client retention, annual subscriptions, monthly subscriptions, drop off rates, accurate prediction, sales assumptions, profit forecasting, business planning, financial reporting
In this episode, Kayla Durck discusses the common fitness goals of women, focusing on body recomposition, losing fat while building muscle. She emphasizes the importance of understanding body composition, the misleading nature of the scale, and the hormonal fluctuations that can affect weight. Kayla outlines the challenges of achieving simultaneous goals, the necessity of a structured approach to nutrition and training, and the key components for successful recomp, including adequate protein intake and progressive training. She also addresses common myths and frustrations women face in their fitness journeys, encouraging patience and consistency for long-term success.Chapters00:00 Understanding Body Recomposition00:00 The Science Behind Recomping00:00 The Role of Body Composition02:16 The Scale: A Misleading Metric04:25 Mindset Shifts for Effective Recomping08:16 Caloric Surplus vs. Deficit in Recomping11:47 The Challenges of Simultaneous Goals14:35 Navigating Progress Plateaus17:06 Creating Structure in Your Fitness Journey20:04 Finding Balance and Avoiding Burnout21:13 Strategic Recomposition: The Importance of Load and Nutrition25:09 The Core Components of Successful Recomp: Training and Nutrition28:44 Common Pitfalls in Recomp: Training Hard vs. Training Smart34:17 Debunking Myths: Understanding Weight Training and Fat Loss41:28 The Long Game: Patience and Consistency in RecompWatch on YoutubeIf you are ready for support in reaching your goals this year, apply for 1:1 coachingShare feedback/send fanmailFreebies/ProgramsTransformation Roadmap + Free Training (Why You're Stuck and How to Get in the Best Shape of Your Life)Apply for the Transformation ProgramHigh Protein/Macro-Friendly Recipe eBookAll links Support the showInstagram | TikTok | YouTube | Pinterest
In this episode of Call Your Hits, Phil and Pat delve into the critical role of communication in Airsoft, particularly focusing on radio usage. They discuss common pitfalls players encounter, strategies for effective communication, and the importance of establishing protocols. The conversation emphasizes the need for clarity, brevity, and actionable information in comms, while also highlighting the value of silence. The hosts encourage players to practice their communication skills and engage in after-action reviews to continuously improve. Overall, the episode serves as a comprehensive guide for Airsoft enthusiasts looking to enhance their communication on the field.Chapters00:00 The Importance of Communication in Airsoft07:01 Common Pitfalls in Airsoft Communication14:06 Strategies for Effective Radio Communication20:36 Establishing Radio Protocols and Etiquette28:12 Effective Communication in Airsoft32:04 Key Elements of Radio Communication35:48 Actionable Information and Context39:57 The Importance of Brevity and Clarity45:00 After Action Reviews and Continuous Improvement55:08 Simplifying Communication for Better Coordination--- If you're looking to support the channel, check out our merch store here: https://stormriders.threadless.com/ And join our discord by following this link: https://discord.gg/ZdaftDDYaZ
ResourcesEpisode 167. Achievable Strategies to Make Your Marriage the Foundation of Your Blended FamilyEpisode 206. Avoid These 5 Common Pitfalls to Ensure a Successful PartnershipEpisode 139. The Most Common, Challenging Pain Point Every Blended Couple Experiences (Trapped Teammate / Stranded Stranger dynamic)Episode 77. 3 Unique Differences That Make a Blended Family Marriage ChallengingEpisode 160. A 4-Part Framework for Achievable Expectations and How to Live Them OutEpisode 130. How to Build Trust that Nurtures Bonds with Your Kids and StepkidsEpisode 214. Does Permissive Parenting Help or Hurt? Discover How to Know and GrowEpisode 37. Why do kids struggle to accept their stepparent?Suggest a Topic or Ask a Question Would you like us to discuss something specific or answer your question on the show? Let us know!We've made it easy. Just click here: https://www.blendedfamilybreakthrough.com/shareReady for some extra support?We all need some extra support along the blending journey — we're here to help. You can connect with us for a free coaching call to see how we might help you experience more clarity, confidence, and connection in your home. Schedule your free call here: https://www.blendedfamilybreakthrough.com/free-callSubscribe or Follow the Show Are you subscribed or following the podcast yet? If not, we want to encourage you do that today so you don't miss a single episode. Click here to subscribe in Apple PodcastsClick here to follow on SpotifyLeave a Review in Apple PodcastsIf you're feeling extra helpful, we would be so grateful if you left us a review over on Apple Podcasts too. Your review will help others find our podcast — plus they're fun for us to read too! :-) Just click here to Review, select “Ratings and Reviews” and then select “Write a Review” — let us know what your favorite part of the podcast is. Thank you, we really appreciate your feedback!
In this episode of "Next Steps 4 Seniors," host Wendy Jones and guest Wendy Zimmer Cox, an estate planning expert, discuss the essentials of financial security and estate planning for seniors. They highlight the importance of having key legal documents, choosing the right decision-makers, and organizing vital information in a “death binder.” The conversation covers common pitfalls, such as joint bank accounts and family disputes, and stresses clear communication and proactive planning to prevent conflict and ease transitions for loved ones. Listeners are encouraged to seek professional guidance and start these important conversations early. Be sure to like and subscribe on your favorite podcast platform so that you never miss an episode. Every week brings two ways to grow: Tuesdays dive into the physical next steps with real-life guidance for seniors and families, and Fridays uplift the heart with spiritual and emotional next steps—encouragement, faith, and hope for the journey ahead. To learn more about Next Steps 4 Seniors, contact us at 248-651-5010 or visit us online at www.nextsteps4seniors.com Find us on YouTube at https://www.youtube.com/@nextsteps4seniorsLearn more : https://nextsteps4seniors.com/See omnystudio.com/listener for privacy information.
Are you planning to transform your backyard into a stunning retreat? Mike and Trey Farley of Farley Pool Designs, who have over 40 years of experience, share invaluable insights in this episode of the Luxury Outdoor Living Podcast. With key topics like why you shouldn't pay for the entire pool up front, the dangers of incomplete contracts, and the importance of accurate 3D modeling, they ensure you avoid common pitfalls. They also touch on the necessity of hydrostats to prevent pools from floating, the repercussions of groundwater issues, and why adhering to proper safety standards for diving entries is crucial. Whether you're looking at a simple design or a complex resort-style oasis, this episode empowers homeowners to approach their outdoor projects with confidence and avoid costly mistakes. https://www.farleypooldesigns.com/ https://www.instagram.com/farleydesigns/ https://www.instagram.com/luxuryoutdoorlivingpodcast/ https://www.instagram.com/poolzila/ 00:00 Introduction to Luxury Outdoor Living 01:59 Common Pitfalls in Pool Construction 05:03 Design Firm Payment Practices 06:03 Completion Date Promises 12:12 Variable Speed Pumps and Skimmers 14:09 Importance of 3D Modeling in Pool Design 20:32 Detailed Contracts vs. One-Page Contracts 24:16 Handling Cave-Ins During Construction 29:07 Ensuring Accurate Pool Placement 32:08 Unexpected Pool Construction Challenges 33:25 The First Pebble Tech Pool: A Colorful Misunderstanding 36:39 Understanding Gunite Pools and Rebound Issues 42:35 The Hydrostat: Preventing Pool Floatation Disasters 49:57 Easements and Their Impact on Pool Construction 54:41 Dealing with Underground Streams in Construction 01:00:13 The Dangers of Improper Diving Pool Design 01:03:24 Conclusion and Final Tips for Pool Owners
Michael Hladky joins the pod to explain how CSS performance improvements like content-visibility, CSS containment, contain layout, and contain paint can dramatically outperform JavaScript virtual scrolling. The conversation explores virtual scrolling, large DOM performance, and how layout and paint work inside the browser rendering pipeline, including recalculate styles and their impact on INP Interaction to Next Paint. Michael shares real-world examples of frontend performance optimization, discusses cross-browser CSS support including Safari content-visibility, and explains why web performance issues tied to rendering are often misunderstood and overlooked. Links LinkedIn: https://www.linkedin.com/in/michael-hladky-519340148/ GitHub: https://github.com/BioPhoton X: https://x.com/Michael_Hladky Resources Conference link: https://push-based.io/event/perfnow-2025-michael-hladky-zero-js-virtual-scrolling-css Conference resource: https://github.com/push-based/css-contain-and-content-visibility-research We want to hear from you! How did you find us? Did you see us on Twitter? In a newsletter? Or maybe we were recommended by a friend? Fill out our listener survey! https://t.co/oKVAEXipxu Let us know by sending an email to our producer, Elizabeth, at elizabeth.becz@logrocket.com, or tweet at us at PodRocketPod. Check out our newsletter! https://blog.logrocket.com/the-replay-newsletter/ Follow us. Get free stickers. Follow us on Apple Podcasts, fill out this form, and we'll send you free PodRocket stickers! What does LogRocket do? LogRocket provides AI-first session replay and analytics that surfaces the UX and technical issues impacting user experiences. Start understanding where your users are struggling by trying it for free at LogRocket.com. Try LogRocket for free today. Chapters 00:00 Introduction to CSS Performance and Virtual Scrolling 01:20 Why Interaction to Next Paint (INP) Changed Everything 03:00 The Real Cost of Layout and Paint 05:10 Why Large DOMs Break Performance 06:45 How CSS Containment Works 08:30 Contain Layout vs Contain Paint Explained 10:40 When Containment Breaks Your UI 12:20 Introducing Content Visibility 14:10 CSS Content Visibility vs JavaScript Virtual Scrolling 16:40 Why CSS Skips Recalculate Styles Entirely 18:50 Real Performance Gains on Desktop and Mobile 20:40 Cross-Browser Support Including Safari 22:10 Common Pitfalls and Flickering Issues 24:10 How to Measure Layout and Paint Performance 26:10 Why Frameworks Should Use This by Default 28:00 Design Systems and Low-Hanging Performance Wins 30:10 The Biggest CSS Performance Misconception 32:00 Final Takeaways on Frontend Performance
Speed in Golf: How to Add Distance Safely (and Make It Transfer to the Course)A lot of golfers come into winter with the same goal: hit it farther next season. In this episode, Michael Falk and Jason Tipton break down why speed matters in today's game, what separates swinging harder from swinging faster, and how to build real distance gains that actually hold up on the course.You'll learn why ball speed is the KPI (not just clubhead speed), how center contact and efficient sequencing can unlock speed without extra effort, and why speed training needs a plan—both technically (setup, sequencing, ground forces) and physically (strength, power, rotational capacity). They also cover where overspeed tools fit, what typically goes wrong when golfers chase speed without feedback, and how to create a training blueprint that improves distance without losing your scoring skills.What You'll LearnWhy distance is such a performance advantage (and where the “too much speed” line can show up)Ball speed vs. clubhead speed — and why strike + launch conditions often beat max effortCommon mistakes golfers make when they start speed trainingThe technical foundations that create speed: setup, sequencing, and ground force timingPractical tools/drills that help golfers learn to create speed efficientlyThe physical drivers of speed: strength, power, and rotational explosivenessHow mobility fits in (important, but not the main driver for everyone)A blueprint approach to gaining 10–15+ yards with less wasted effortWhat goes wrong when speed training is unbalanced (and how to avoid it)Timestamps00:00 Introduction and Episode Overview01:15 The Importance of Speed in Golf (tour trends, scoring advantage, distance thresholds)06:14 Physical Fitness and Speed Training (better athlete = more potential speed, aging + maintaining speed)08:21 Common Mistakes in Speed Training (“swinging harder” vs “swinging faster,” dispersion early on, ball speed focus)15:44 Technical Aspects of Building Speed (setup/grip, kinematic sequence, ground-up movement, face/path issues when forcing speed)20:49 Innovative Training Tools for Golf (force pedal, constraints, continuous swings for balance and sequencing)21:24 Balancing Swing Sequencing and Speed Training (overspeed as a tool—not the tool; efficiency before effort)22:14 The Role of Physical Fitness in Golf Performance (why gym work supports speed development)22:49 Key Drivers of Club Head Speed (vertical impulse, upper-body explosiveness, rotational power)23:42 Importance of Flexibility and Mobility (helpful for some, but not the primary driver in most research)26:24 Creating a Personalized Training Blueprint (screening + player-specific plan; gym frequency; adding overspeed strategically; tracking)32:58 Common Pitfalls in Speed Training (open face/face control, losing wedges/scoring, overuse issues, poor warm-up/recovery)37:59 Recap and Future Plans (assess → efficiency → build capacity → add speed → track; upcoming episodes)Resources MentionedJason Tipton (Skillest): online assessment + lessons https://skillest.com/coach/jason-tiptonKinetic Sports Medicine & Performance: golf assessment https://kineticsmp.com/golf
In this engaging conversation, Kevin and Mike delve into the evolution of Mike's welding business, Rockin' Two Industries, which he started in 2012 with no prior experience. Mike shares his unique journey from a novice welder to a successful business owner, emphasizing the importance of networking and collaboration within the welding community. He discusses how he built connections through social media and local groups, which have been instrumental in his growth. The conversation also touches on the challenges of managing a team, maintaining a positive work culture, and the significance of saying 'no' to unprofitable projects to ensure sustainable growth.As they explore the intricacies of running a welding shop, Mike reflects on the importance of building a network within the industry and the value of collaboration over competition. He stresses that many welding business owners make the mistake of trying to grow too quickly without establishing a solid foundation. The episode wraps up with insights on project management tools and the necessity of adapting to the evolving needs of the business, highlighting the importance of continuous learning and improvement in the welding industry.Takeaways"I didn't know what I was doing. Got on YouTube and 13 years later, here I am.""Saying no has been the hardest thing for you to do in business.""The internet for the welding business has been really, really helpful for a lot of us.""If you're not thinking, if you're like the old school mindset of competition, you better rewire it or you're just going to fizzle out.""I will protect the culture of this shop at all costs." "It's tough to balance that out.""You have to have that base in place.""It's better to stay small and perfect what you're doing.""If you can justify that, go get it.""You need to get out there and knock on some doors.""You can't get rid of that.""There's a cost to changing gears.""You have to charge for that or else it catches up to you.""Creating that network is a pretty big deal.""You need to have the will to make it work."Chapters00:00 Introduction and Setup02:09 Mike's Unique Journey into Welding05:05 The Power of Networking in the Welding Community08:35 Profit Sharing and Collaboration with Other Businesses17:32 Managing a Team and Maintaining Work Culture26:48 Future Aspirations for Rockin' Two Industries33:49 Team Skills and Project Diversity35:25 Overview of Shop Projects42:18 Challenges of Business Growth46:16 Learning to Say No50:15 Customer Relations and Advertising Strategies57:24 Financial Lessons Learned01:09:51 The Right Tools for the Job01:11:00 Space Constraints and Shop Organization01:15:58 Common Pitfalls in Business Growth01:19:54 Lessons Learned and Advice for New Owners01:24:06 Managing Projects and InvoicingI want to hear from you guys! I'm blocking out a bunch of time over the next two months to record podcasts And I want to hear from you guys! I want to hear the good, the bad, the ugly, the funny, and everything in between. Reach out to me on Instagram or shoot me an email at Kevin@JMWfabrication.com From there I'll reach out and send you a link to our Google Calendar to pick out what time is best for you to ho on a call. Merry Christmas and Happy New Years!
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The holiday season can be especially challenging for those who've experienced betrayal. This episode explores how coaches and practitioners can help clients navigate the pain that surfaces during this time and introduces the strategic framework of the five stages from betrayal to breakthrough. Key Topics Covered The Holiday Challenge The holidays bring up complex emotions for those who've been betrayed: Memories of past celebrations become painful Questions arise about what the betrayer was thinking during previous happy moments The season amplifies unresolved trauma How Unhealed Betrayal Shows Up Betrayal affects clients across all coaching specialties: Health Coaches: Clients may struggle with emotional eating, binging, or sabotaging healthy protocols due to underlying betrayal trauma. Digestive Health Practitioners: 45% of betrayed individuals develop gut issues (Crohn's, IBS, diverticulitis, constipation, diarrhea). Even excellent protocols may fail without addressing the root betrayal. Business Coaches: Clients may sabotage success, struggle with confidence, avoid promoting themselves, or have difficulty delegating due to shattered trust. Life Coaches: Clients appear stuck, unable to find clarity or purpose because they're trapped in betrayal trauma. The Five Stages Framework Understanding where clients are stuck is crucial: Stage 2: Nervous system dysregulation prevents clients from hearing suggestions Stage 3: The most common stuck point where clients settle for "solid ground" rather than pursuing growth Stages 4 & 5: Where transformation happens—new health levels, passion projects, businesses, and relationships become possible Signs Your Protocols Aren't Working Client demonstrates patterns of self-sabotage Excellent strategies fail to produce results Client seems unable to move forward despite wanting to Symptoms persist despite proper treatment The Transformation Process When betrayal is addressed: Health protocols begin working effectively Confidence returns for business pursuits Trust rebuilds systematically Physical symptoms of Post Betrayal Syndrome disappear Clients look years younger as chronic stress reduces Common Pitfalls to Avoid Therapy Without Betrayal Expertise: Well-meaning therapists may keep clients feeling heard but stuck in Stage 3 Couples Counseling Issues: Often minimizes betrayal, lacks accountability, and frustrates the betrayed partner Support Groups: Can inadvertently encourage people to sabotage healing to maintain their community Numbing Behaviors: Medication, substances, work, or scrolling prevent actual healing Why People Stay Stuck Fear of outgrowing their support system Fear of outgrowing their betrayer Settling seems safer than risking more pain Not knowing there's a roadmap forward The Power of PBT Coaching Certified coaches use the five-stage roadmap while bringing their unique strengths: Some work with couples, others with individuals Specializations include military families, faith-based approaches, empaths, men, women All share the strategic framework while applying personal gifts Results of Moving Through the Stages New levels of physical health and vitality Transformed or new relationships Passion projects and new businesses Access to opportunities not visible while stuck Deep sense of fulfillment and purpose Upcoming Opportunity Free Masterclass: Becoming a Certified PBT Coach or Practitioner Date: December 11 at 11am Pacific For: Coaches, practitioners, HR professionals, therapists, doctors, counselors Special Offer: Holiday bonus gifts available (details revealed in masterclass) Register: ThePBTinstitute.com/certification-masterclass Note: Replay available to all registrants Key Takeaway Whether you're struggling with betrayal during the holidays or you're a professional who wants to help others heal, there's a proven roadmap that shortens years of pain. The goal isn't just to return to the old life—it's to create something richer, healthier, and more fulfilling. "The more coaches certified with their own spin, talents, and strengths, the more people get the help they need to move through something they never saw coming."
In this engaging conversation, Bob Castellini shares his journey as a successful entrepreneur and the founder of a virtual family office. He discusses the importance of planning for business exits, the six forms of capital that contribute to wealth, and the unique investment strategies employed by family offices. Bob also reflects on his family's legacy in the produce industry and emphasizes the significance of community stewardship through sports ownership. Ultimate Show Notes: 00:01:30 - Overview of Bob Castellini's Background and Experience 00:03:50 - Explanation of Sentinel Private Wealth Group and Its Services 00:08:10 - Discussion on the Six Forms of Capital and Their Importance 00:10:30 - Common Pitfalls for Business Owners During Exits 00:13:50 - Insights on Investment Strategies of High Net Worth Families 00:24:00 - Bob Castellini's Personal Story and Family Business Legacy 00:27:30 - Community Involvement and Impact of the Cincinnati Reds Connect with Bob on Social: https://www.linkedin.com/in/bobcastellini/ Learn More About Accountable Equity: Visit Us: http://www.accountableequity.com/ Access eBook: https://accountableequity.com/case-study/#register Turn your unique talent into capital and achieve the life you were destined to live. Join our community!We believe that Capital is more than just Cash. In fact, Human Capital always comes first before the accumulation of Financial Capital. We explore the best, most efficient, high-integrity ways of raising capital (Human & Financial). We want our listeners to use their personal human capital to empower the growth of their financial capital. Together we are stronger. LinkedinFacebookInstagramApple PodcastSpotify
This is a very special episode for me. My brand-new card game, COYOTE, created in collaboration with Elan Lee and Exploding Kittens, is here. It is available in ~8,000 locations worldwide, including Walmart, Target, Amazon, and many others. Learn more: https://coyotegame.com.This episode is brought to you by: Gamma AI design partner for effortless presentations, websites, social media posts, and more: https://gamma.app (use code TIM at checkout for one month off on their annual plan) Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you're ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps (will be updated): 00:00 Intro 05:21 The Journey to Creating a Game05:51 The Creative Process Behind Coyote17:16 The Importance of Constraints in Creativity35:04 The Toronto Sprint41:02 The Evolution of Coyote: From Concept to Prototype47:36 Game Design Principles and Recommendations51:53 Introduction to 'Don't Shoot the Dog'53:25 Simplifying Game Design58:55 Playtesting and Iteration01:08:10 Finding the Sweet Spot in Game Difficulty01:14:35 The Success of 'Hurry Up Chicken Butt'01:22:26 Testing and Feedback Process01:34:49 Pitching to Big Retailers01:36:19 Designing the Perfect Game Box01:36:31 Testing and Validating Game Designs01:41:23 The Road to Retail Success01:43:51 Keys to a Successful Line Review01:44:29 The Role of Agents and Publishers02:07:56 Crowdfunding and Self-Publishing02:19:56 Understanding Game Publishing Deals02:27:40 Common Pitfalls in Game Packaging and Marketing02:38:39 Navigating Retail and Distribution Challenges02:47:25 Final Thoughts and a Tantalizing Offer*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.