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Shannon and Mary record their Season 8 finale, catching up on what they've been doing during the school year.    They've both been busy with balancing personal and professional responsibilities, with work hours increasing for Shannon in tutoring and for Mary in advocacy work and supporting parents in IEP meetings.   In their tutoring practices, they're both advancing beyond decoding work with many of their students, and during the discussion, they both realized they had adopted sentence-composing activities, inspired by 8.8's guest, Sara Lee.   During the discussion, they detail how their students use literature-based model sentences and scaffolded imitation to build sentence skills, comprehension, and vocabulary.   Shannon describes how she adds language support using English Linking Blocks and word lists.   The discussion then highlights their excitement about UFLI's upcoming structured morphology curriculum, Word Origins (adapted from Australia).   In the episode chat, they also touch on the AMIRA screener, Mary's recent SWI professional learning through Word Torque, and how they're both supporting students' math knowledge and skills in their tutoring.   Listen in to catch up with these reading teachers and find out how their literacy instruction continues to evolve.00:38 Life as Busy Parents02:30 Tutoring and Advocacy Load04:29 Discovering Sentence Composing07:37 Harry Potter Hook09:17 Linking Blocks Breakthrough13:18 From Sentences to Writing19:43 Structured Morphology Word Origins22:58 Structured Morphology Wins23:48 Curriculum Fidelity First27:06 Word Origins Details28:41 Australia Connections31:17 Getting It Into Schools32:15 Georgia Reading Screening37:59 Math Fluency Intervention40:22 Subitizing And Word Problems47:12 Wrap Up Season NotesRECOMMENDED RESOURCES RELEVANT TO THE EPISODE:UFLI Word Origins news updates formUFLI Word Origins InformationHands-On English Linking BlocksWord Torque websiteWord Inquiry In ActionReviews of Curriculum - The Reading LeagueGA Dyslexia Handbook related to updated laws for HS 307Math Their WayAubree Teaches - conceptual, visual math Aubree Teaches - store (this is not an affiliated link)Support the showGet Literacy Support through our PatreonBonus Episodes access through your podcast appBonus episodes access through PatreonBuy us a coffeeGet a FREE Green Chef box using our link

Eagle pose ~ Wednesday (14 July 2010 - Zurich, SWI)

In this episode of the The Mission Matters Podcast, Matthew Ellison and Ted Esler sit down with  Dennis Martin (of One Challenge's Sexual Wholeness Initiative) to address a largely unspoken issue in global missions: sexual sin/brokenness. Drawing from both personal experience and global research, Dennis explains how silence, shame, and isolation have allowed struggles like pornography, abuse, and other sexual challenges to persist among missionaries. He highlights that these issues are far more widespread than many assume, often intensified by the pressures of cross-cultural ministry and lack of safe, honest community. The conversation points toward a different path forward—one centered on grace, honesty, and restoration rather than punishment. Dennis shares how mission agencies are beginning to shift their culture by creating safe environments, equipping leaders, and walking alongside individuals through long-term healing processes. Through practical examples and real stories, he emphasizes that freedom is possible when people are no longer alone. The episode challenges churches and mission leaders to break the silence, rethink their approach, and build communities where confession leads to healing, not exit.OC's Sexual Wholeness Initiative (SWI), spearheaded by Dennis Martin, seeks to change the culture of silence and shame and, by bringing these secret struggles to light, offer freedom and restoration to those whose lives have been shackled by sin. By equipping our staff to create a climate of openness, safety, and redemption and integrating sexual wholeness into our ministry efforts, OC envisions a future in which generations of laborers live and minister out of sexual wholeness and relational health in Christ.The Mission Matters Podcast is a place to talk about the importance of our Mission as Christians. The Mission Matters is a partnership of Missio Nexus and Sixteen:Fifteen, who have a shared passion to mobilize God's people to be a part of His mission.SWI@oci.orgRegister for the MissioNexus Mission Leaders Conference 26https://web.cvent.com/event/654a1d2b-f757-4491-a480-fc3f68a2ccc5/websitePage:42fd7167-2fba-4de5-9c38-1540ddbaed85?RefId=events

Adult‑onset leukodystrophies, though rare, can closely mimic MS on both clinical presentation and neuroimaging, posing a significant diagnostic challenge. This episode highlights key clinical and radiologic red flags that can help distinguish these disorders from MS, preventing misdiagnosis and avoiding inappropriate treatment while enabling timely genetic counseling and targeted therapies. In this episode, Teshamae Monteith, MD, FAAN, speaks with Roberta La Piana, MD, PhD, coauthor of the article "Adult-Onset Leukodystrophies Mimicking Multiple Sclerosis" in the Continuum® April 2026 Multiple Sclerosis and Related Disorders issue. Dr. Monteith is the associate editor of Continuum® Audio and an associate professor of clinical neurology at the University of Miami Miller School of Medicine in Miami, Florida. Dr. La Piana is an associate professor in the Department of Neurology and Neurosurgery at the Montreal Neurological Institute, McGill University, and an associate member of the Department of Diagnostic Radiology at McGill University in Montreal, Quebec, Canada. Additional Resources Read the article: Adult-Onset Leukodystrophies Mimicking Multiple Sclerosis Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @headacheMD Full episode transcript available here Dr Monteith: You just saw a patient in clinic. And you're clear, the diagnosis is multiple sclerosis. Not everything fits, but it kind of looks like multiple sclerosis. You see the patient back years later. There're some treatment issues, the patient's not responding to treatment, and things look different. Have you thought about a genetic inherited problem like leukodystrophy or a genetic white matter disorder? Listen to this podcast. We're going to help you figure it out. Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Monteith: This is Dr Teshamae Monteith. Today I'm interviewing Dr Roberta La Piana about her article on adult-onset leukodystrophies mimicking multiple sclerosis, which she wrote with Dr Gabrielle Macaron. This article appears in the April 2026 Continuum issue on multiple sclerosis. Welcome to our podcast.  Dr La Piana: Thank you. Thank you for having me.  Dr Monteith: Absolutely. Why don't we start off with you introducing yourself? Dr La Piana: So, my name is Roberta La Piana. I'm a pediatric neurologist. I trained in Italy, I did my medical school, I did my residency in pediatric neurology there. And then I moved here to Montreal, to the Montreal Neurological Institute, to do a PhD in neuroscience. And that's where I specialized in adult-onset genetic white matter diseases. And after my PhD, I was recruited as an assistant professor here. So, that's where I got into this field.  Dr Monteith: This big field, highly specialized; lots of disorders, but highly specialized. And what got you into this? Neuroscience is huge. So, was it a mentor, or…?  Dr La Piana: No, actually, it was because of my background, because I trained as a pediatric neurologist and I loved the genetic white matter disorders in the pediatric population. So, when I came to the Montreal Neurological Institute, initially it was mainly to have a better expertise in imaging. And being at an adult neurology institute, I started seeing patients with adult genetic white matter diseases, and I was immediately fascinated by how different they were from their pediatric counterparts. Because in pediatric genetic white matter diseases, pediatric leukodystrophies look very diffuse, look very confluentous, so it's difficult to mistake them. But in adults, in the adult forms, I was initially driven by how often they can be misdiagnosed as multiple sclerosis or as other acquired white matter disorders. So that's why I got really interested in in this field.  Dr Monteith: You're, like, literally the perfect person for this discussion.  Dr La Piana: I'm not sure- *laughs* Dr Monteith: Why don't we start off with what your objectives were when writing this article? Dr La Piana: With writing this article, the goal is what I have been, actually, doing for the past ten years or so. So, really try to get more attention into the field because of the high rate of potential misdiagnosis of patients. So, that's exactly the reason why I really would like to raise the interest of neurologists for these disorders, because they are not considered enough in the differential diagnosis of patients, of adult patients presenting with white matter disorders. They are considered rare---which are, they are rare, definitely. But collectively, while each single form is rare, collectively they are not as rare. So- and thus, the risk of misdiagnosis and the potential impact of misdiagnosis on them with, you know, you can imagine giving patients inappropriate treatment or missing the possibility of a prenatal genetic diagnosis is so high that I really would like people to keep these disorders in the differential.  Dr Monteith: And it sounds like more than ever, this is really important because some of the newer developments in the field. Dr La Piana: Yes. Specifically, we have now tools that will allow to diagnose these patients quite quickly. All the genetic techniques that are available nowadays can really, with one single shot, we can now sequence hundreds of genes so we can have a quicker diagnosis. And this thing was impossible up until ten years ago. So that's definitely the first huge improvement that makes these disorders now easily diagnosed. Dr Monteith: Yeah. So why don't we talk a little bit about how common is this misdiagnosis for these rare subtypes? Dr La Piana: Yeah, the misdiagnosis, it depends on the cohorts. Generally speaking, I would say that the rate of that misdiagnosis for these forms is up to 25% or even more in some other cohorts. And it really depends on the forms. Like, there are clearly some forms, especially those that present with multifocal white matter diseases, that present with nonspecific clinical presentations like migraines, image---and especially for female patients, and for which migraine is so common, having multifocal with other abnormalities is so common, the rate of diagnosis increases even further. So, these are all things that we need to keep in mind. I know these are rare, but still, we need to always have them on the back of our minds.  Dr Monteith: Are there any particular disorders that are more often misdiagnosed? And you spoke about progressive forms of multiple sclerosis being a common kind of misdiagnosis.  Dr La Piana: Yeah. So, there are definitely forms that are more commonly misdiagnosed. And these are those that, as I probably repeated already too many times, is the word multifocal, which is key. So, all those genetic white matter disorders that present with multifocal white matter abnormalities are not initially considered as genetic. So, I'm thinking about all of the leukovasculopathies, so, the small vessel diseases which are genetic in origin. For example, CADASIL; for example, the disorders related to collagen-4; so, the COL4 A1 or A2-related disorders. Those are clearly more commonly misdiagnosed initially. Another big group, unfortunately, is the CSF1R-related disorders. I know I'm saying a lot of gene names, but due to the fact that they start with multifocal abnormalities and they start with quite nonspecific, slowly progressive symptoms, the rate of misdiagnosis is definitely higher. Dr Monteith: And can you discuss some of the clinical challenges when seeing patients that might lead to this misdiagnosis?  Dr La Piana: There are multiple clinical challenges. One is definitely the presence of nonspecific or initially mild clinical symptoms that sometimes don't raise initially the red flag of something, degenerative or progressive or genetic. One category that I would mention are psychiatric disturbances, especially in the form of depression, anxiety, or apathy. This is quite common in patients with some forms of genetic white matter disorders, and they are initially misdirected to psychiatrists and taken care in that domain. But it's only when some even mild neurological symptoms like a gait disturbance or hyperreflexia, or we had patients with, like, a urinary incontinence. It's only at that time, but maybe years have passed meanwhile, that these patients are finally referred to the neurologist Dr Monteith: You spoke about some of these clinical symptoms. Can you give us some other clinical red flags?  Dr La Piana: Well, some other clinical red flags can be, for example, the extraneurological involvement. So, we have patients where- and there's a reason immediately to some specific disorders. For example, infertility. The presence of infertility in a female patient with white matter disorders should immediately form the consideration of the specific genetic white matter diseases that are associated with these forms. And this is not something that neurologists tend to ask about in the collection of the clinical history. And this is something that can make the difference and can accelerate the diagnosis.  Dr Monteith: What are some other things? I mean, I know we can think about treatment, lack of a common treatment response, maybe, to steroids. You gave a great example of optic neuritis, for example. Give us some other things that we should say, hey, this doesn't fit the picture. Red flag.  Dr La Piana: In this case, I think we want to talk more about the specific misdiagnosis of MS. Because these patients are often misdiagnosed with MS, but they might sometimes be misdiagnosed with other forms of acquired white matter diseases. When we consider MS, definitely the presence of being treatment resistant: so, patients that are not responsive to the common MS-targeting treatment should be always a red flag. The evolution as well. So, for example, the presence of a more slowly progressive course is another red flag. The presence of optic neuritis. Sometimes it's tricky because it's not common in the genetic white matter disorders, it's used as a criterion to orient correctly towards a multiple sclerosis. But we need to keep in mind that there are forms, genetic forms, especially the mitochondrial forms, that can present with optic neuritis and are really at the overlap with the multiple sclerosis spectrum. Then, if we want to move forward beyond the clinical side and go into the laboratory, of course a negative lumbar puncture with no oligoclonal bands should be a major red flag. Dr Monteith: What about some of the radiographic features?  Dr La Piana: So, the radiographic features is something we are really working on in the field, especially with the new criteria used in MS. So, for example the paramagnetic rim lesions or the central vein sign, they are considered the specific forms. But it's true- and don't have an answer for that. I want to be clear, but it's true that they haven't been assessed yet extensively in patients with genetic white matter disorders. Anecdotally, I can say, because I have already reported this at conferences, that we have seen patients with genetic white matter conditions reaching a threshold for a central vein sign that can be considered diagnostic for MS. And we have seen that in some patients. Again, no study has been carried out extensively to date, but I think we should consider that with a grain of salt. But yeah, the paramagnetic rim in lesions is probably more accurate to distinguish between genetic and acquired white matter disorders.  Dr Monteith: And what about some of the genetic white matter disorders that mimic MS? You spoke about things like CADASIL; what are other things that we should keep in the back of our mind? And you have great charts, to our listeners, and they're going to have to review those charts, because they're excellent. I think maybe they need to find a way to make that a little bookmark you walk around with on the ward. But what are some other conditions that kind of commonly mischaracterized?  Dr La Piana: Two of the main groups are the one that you mentioned. So, leukovasculopathy is- so, CADASIL, is definitely one of the most common misdiagnoses of MS. And the presence, as we said, of some clinical features like migraine, especially when it's complicated migraine with visual aura, we all know that. But especially in the context of a positive family history for either a psychiatry condition or migraine as well, or strokes, these are all factors that should prompt the consideration of these disorders in the differential of a patient with white matter disorders. Another category are definitely mitochondrial disorders, which I think are more neglected than others because we don't think about mitochondrial disorders when we see white matter disease; we tend to consider that mitochondrial disorders are a problem of the gray matter, but they are not. There are white matter diseases that have definitely mitochondrial. And the third category are probably microgliocytes, which are represented by the CSF1R-related disorder. And this is also something that is clearly quite prevalent, relatively prevalent, in the field of genetic white matter disorders misdiagnosed as MS.  Dr Monteith: Yeah. Why don't we go through some of the, kind of, key history, you know, some of the key questions you would ask in the history to try and differentiate? You mentioned kind of subtle symptoms, longstanding progressive symptoms. I know things that we look at like relapsing/remitting and some trigger factors can actually be associated with some of these genetic disorders. So how do you approach a patient? What are some of the key questions? You talked about family history and you talked about medical history, but why don't you kind of give us a nice way to kind of hone in on to the patient? Dr La Piana: There are a couple of questions that we usually ask. I should make a disclaimer, though, that I work very closely with the MS clinics, so we are ready to receive patients that are prescreened. So, these are already patients that people working on acquired white matter disorders feel like they are atypical, so they want our opinion. But usually, there are two groups of questions that we always ask. One is about the family history. And by saying family history, I really dig into the family history. I don't just want to know whether there are family members with neurological disorders. I ask specifically about migraine. I ask specifically about infertility issues. I ask specifically about psychiatric issues. These three things are always on the top of my mind when asking about family history. The other thing is a family history for neurodevelopmental disorder, because you know that some people might not remember that some genetic white matter diseases can present at different ages. So, in the same family, there might be cases with a pediatric-onset leukodystrophy, and that can manifest at a later age in other family members. So, this is something that we always explore. In terms of the clinical history, one question that I recommend always to ask is really about more subtle symptoms. So, for example, many of our patients present with progressive balance problems or progressive mobility issues that have been going on for a while. So, we always ask how they were when they were in their teenage years, for instance. And it's frequent that they say, actually, I was a bit clumsy. Actually, I was not the first being picked in school at phys-ed sports. And these are all interesting aspects. Maybe they are totally incidental, and sometimes they suggest that there was probably something going on for a long time. The other thing is the presence, for example, of learning difficulties. Again, these are things that are subtle but testify that there was probably a process that was more longstanding. Dr Monteith:  You talked about things like rim lesions. Are there other types of sequences that might be useful to better characterize demyelinating diseases that are genetic in origin? I assume higher levels of MRI might be better at differentiating.  Dr La Piana: Yeah. So, in the clinical setting, there are a couple of sequences that are very useful. One is the diffusion, because as opposed to multiple sclerosis, the presence of persistently restricted areas of diffusion can point immediately towards some genetic white matter diseases. One is CSF1R-related disorders. But there are also some other, more rare tremor and ataxia syndrome that present with persistent areas of restricted diffusion as well as others. The presence of calcification. So, adding an SWI, susceptibility weighted imaging, to check not just for calcifications that can immediately orient towards some disorders, but can also identify areas of microhemorrhages that, if we are going back to the leukovasculopathies, to the genetic leukovasculopathies, can tell us that we are on the right track for excluding those type of diseases. Basically, these are the two that are available in every scanner without even going into fancy, more advanced techniques. Dr Monteith: I was going to ask you that question, how often should we think about this next-generation sequencing when you're kind of on the fence, allowing for some negative results to come back in the abundance of caution?  Dr La Piana: The problem with the panel, of course, is that you run a panel and you don't know what's coming back. So, then having to deal with variants of unknown significance in genes, then you have to deal with them, and then you have to deal with results that maybe are not as black or white as you would expect initially. So, I'll answer to your question when to do that, our recommendation would be to do that every time you are presented with a patient that presents those atypical features that we summarized in the paper, and that basically raise multiple red flags for an atypical white matter disease that is not multiple sclerosis. And then what to do when you have results? I still believe that having access, of course, to genetic counselors, to neurogeneticists, is critical, but also having access and being in contact with the network of people working on this. Because we are a network; we put the website address on the paper of the white matter rounds because this is an international network that we built over the years, and we connect monthly, on a monthly basis, with meetings to discuss exactly this type of patient. So, we are all learning together, and it's very frequent that people ask us to present cases at the white matter rounds because they have a presented with unusual or atypical genetic findings and they want the opinion of experts.  Dr Monteith: Great. Well, I'm really glad that resource is available. And I'm also really glad that you wrote that article with your colleague. Thank you so much. Dr La Piana: Thank you so much, Tesha.   Dr Monteith: Today I have been interviewing Dr Roberta La Piana about her article on adult-onset leukodystrophies mimicking multiple sclerosis, which she wrote with Dr Gabrielle Macaron. This article appears in the April 2026 Continuum issue on multiple sclerosis. Be sure to check out Continuum Audio episodes from this and other issues, and thank you to our listeners for joining today.  Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Novel MRI biomarkers, including cortical lesions, the central vein sign, and paramagnetic rim lesions, are highly specific for MS and can aid diagnosis in select clinical scenarios, particularly early in the disease course or in atypical presentations. When used with appropriate MRI sequences, these markers can improve diagnostic sensitivity while helping prevent misdiagnosis. In this episode, Casey Albin, MD, speaks with Jiwon Oh, MD, PhD, FRCPC, FAAN, author of the article "Diagnostic Neuroimaging Biomarkers for Multiple Sclerosis" in the Continuum® April 2026 Multiple Sclerosis and Related Disorders issue. Dr. Albin is a Continuum® Audio interviewer, associate editor of media engagement, and an assistant professor of neurology and neurosurgery at Emory University School of Medicine in Atlanta, Georgia. Dr. Oh is the medical director of the Barlo Multiple Sclerosis Program at St. Michael's Hospital and an associate professor at the University of Toronto in Toronto, Ontario, Canada. Additional Resources Read the article: Diagnostic Neuroimaging Biomarkers for Multiple Sclerosis Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @caseyalbin Full episode transcript available here Dr Albin: Spend any time in a neurology conference, and you are certain to hear about the new central vein sign, which, as I learn, is not actually all that new. But have you heard about cortical lesions or these paramagnetic rim lesions? Because today I have the privilege of talking to Dr Jiwon Oh about her article, and we're going to unpack all these new biomarkers in MS. Dr Jones: This is Dr Lyell Jones, editor in chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Albin: Hello, this is Dr Casey Albin. Today I'm interviewing Dr Jiwon Oh about her article on diagnostic neuroimaging biomarkers for Multiple Sclerosis, which appears in the April 2026 Continuum issue on multiple sclerosis. Welcome to the podcast. Thank you so much for being here. I'd love to start by having you introduce yourself to our listeners.  Dr Oh: Thanks, Casey. Hi, everybody. My name is Jiwon Oh and I'm a neurologist, mainly an MS specialist at Saint Michael's Hospital at the University of Toronto, and I'm the medical director of our MS program. Dr Albin: And you have written a really fantastic article that dives deep into some of the nitty gritty about these new diagnostic biomarkers that we find on the MRI that we're getting for our patients with multiple sclerosis. And I think we are going to get into a lot of that nitty gritty. How do we look for them? How do they improve our diagnostic specificity? This is really come a long way in shaping the advances for multiple sclerosis. And I'd kind of like to just start with the big picture. Like why do we need these more specific biomarkers?  Dr Oh: This set of diagnostic criteria in MS, it's actually a huge change in the field, and particularly for people like me who are really interested in developing new MRI measures, we're really, really excited because it's actually the first time since MRI was officially incorporated into the MS Diagnostic criteria, which was way back in 2001. It's the first time that we've actually been able to get newer, more advanced imaging measures beyond just simply detecting, new T2 lesions in the MS diagnostic criteria. So, it's a big moment in the field, and many of us are really excited about it in terms of why we need some of these newer, more specific imaging measures. Well, you know, diagnostic criteria always evolve over time for any disease state, and MS is one that we've recognized over the years. By the time someone actually presents with typical clinical symptoms and has diagnosed, whatever has been happening from a patho-biological standpoint has been happening probably for almost 5 to 10 years before that individual actually presents. And so, because of this recognition in the field and the fact that we're recognizing how important it is to first diagnose MS and then treat MS earlier and earlier, because we know that early treatment helps prevent more clinical outcomes. Diagnostic criteria over time have become much more permissive, meaning that we're doing everything that we can to try to facilitate a diagnosis of MS when we know that someone biologically has MS. But the problem with making diagnostic criteria more permissive, and it's obviously a good thing because you want to capture as many people with MS as early on as possible. The problem with making it permissive is there is this terrible risk of misdiagnosis. As clinicians, we all think we never make mistakes. But it turns out when you actually do studies, you do. And even at MS specialty centers, when studies have been done, 10% to 20% of people with MS are misdiagnosed. So, this is exactly why we need in diagnostic criteria that really help to facilitate a diagnosis. We need things that help us prevent misdiagnosis as well. And these are these specific imaging measures that have now been incorporated into the diagnostic criteria in many settings that will help to facilitate a diagnosis. But the really big perk is if you use them, you can help to prevent misdiagnosis as well.  Dr Albin: Yeah, that really shone through in your article that this was such a big step in towards being more specific about who were diagnosing. Also capturing more people, right? Trying to get those people that we, we don't want to miss because of all the things you say, you know, that allows them to accumulate more disability, have worse outcomes. Early diagnosis is so important. But I really did take away from your article just how critical these are and sharping our diagnostic acumen. And so just to jump right in, and you describe these three new biomarkers, these cortical lesions the central vein sign and paramagnetic rim lesions. And so just to kick things off let's start with cortical lesions I sort of conceptualize multiple sclerosis a disease of white matter. So, what's going on here?  Dr Oh: Yes. MS classically has always been described as a white matter disease. But it turns out when you look at brain and spinal cord tissue, as well as when you use kind of better sequences to actually look for lesions in the gray matter, it actually turns out there's a ton of lesions in the gray matter as well. And in fact, what's interesting is that regardless of whether it's the cortex or the deep gray matter, it's lesions within these areas that seem to have the highest relevance for clinical disability in MS. So, all this to say, of course, MS is a lesion that does affect white matter, but it also affects gray matter a lot. And maybe pathology within the gray matter is even more relevant to clinical disability. So, this is why we're really interested in being able to develop methods using MRI to more accurately visualize the gray matter, particularly the cortex, as well as deep gray matter structures like the thalamus. I should add the caveat that cortical lesions were actually included in the 2017 diagnostic criteria revisions, but they were included together with juxtacortical lesions, which are a typical area that MS lesions form. And so, this imaging measure, despite the fact that it is relatively novel and we consider it advanced, it hasn't been used that much only because it's not that easy to detect lesions within the cortex. And reasons for this include that you usually need higher field magnet platforms. And so, the typical clinical MRI scanners that are available kind of widely, regardless of whether you're at an academic center or a community center, are 1.5 Tesla magnets. And cortical lesions are actually really difficult to detect on those typical scanners. But when you get to like, say, three Tesla or seven Tesla, they're a lot easier to detect. But obviously that's a big hindrance to widespread use. And then you actually need very specialized sequences to adequately visualize cortical lesions. And these are not sequences that are usually collected for clinical purposes. So, it kind of requires convincing your radiologists that you need this additional sequence. And then it actually takes a lot of time and training to be able to adequately, accurately detect cortical lesions. So, despite the fact that it's actually very useful when you do have the appropriate MRI sequences and scanners to detect cortical lesions, even though they were incorporated into the 2017 criteria outside of specialty centers, they're not actually widely used. But when you do have the appropriate sequences, cortical lesions are actually pretty specific for MS. So, very helpful for a diagnosis in certain settings. But there's all these practical limitations that have really limited its widespread use. Dr Albin: That is a beautiful summary. So, it sounds like once we kind of get up to speed in terms of like the protocols for this, having the magnet strength for this, this will be really a game changer in terms of increasing the specificity and also maybe finding things that impact patient's clinical presentation and therefore quite meaningful. But it sounds like for most of us, this is probably not something that they're going to be adopting right away. Is that a fair assessment?  Dr Oh: Yes. And you know, they were included in the last diagnostic criteria revisions. And it really hasn't changed things very much, only because of these difficulties with, you know, requiring higher field magnet strengths and these specialized sequences and then needing training to kind of figure out how you can adequately detect cortical lesions. Dr Albin: Totally. So, the other thing we've heard a lot about, and I have to say, I was in the AAN fall conference not too long ago, and this came up quite a bit, was the central vein sign and the fascination with that, because it tells us a lot about the MS pathophysiology and again, increasing that specificity. And it seems like maybe this is one that we can more easily adopt in clinical practice. So, tell our listeners about what that is, how they detect it. How many do you need to find?  Dr Oh: Sure. And so, this is one of the imaging measures I'm really excited about. So, the central vein sign heard about it recently. And probably in the last ten years particularly in the MS field we're talking about it all the time. But just wanted to emphasize that the central vein sign is not something that is new. Even back in the 1800s, when Charcot described MS lesions in these ancient textbooks, he actually very clearly described that MS lesions form around the central vein. And that makes sense, because we know that these waves of peripherally mediated inflammation somehow get through the blood-brain barrier and cause this cascade of events leading to inflammation in the brain and spinal cord, which is what MS is. But we know that B cells in T cells require veins to get into the central nervous system. And so, it's no surprise, really, that MS lesions form around veins. And so, this is something that's been known pathologically. But the reason we're so excited about it now is because we actually have good enough iron-sensitive MRI sequences that allow us to see a central vein when it is present within a white matter lesion. As a neurologist, we know that there's probably hundreds and hundreds of different things that can cause white matter lesions in the brain. But when you use an appropriate iron-sensitive sequence and you see that many of them, if not most of them, actually have visible central veins, that tells you that this person very likely has MS. And so that's why we're so excited about it, because there have been many studies done in the last ten years. In fact, so much evidence generated in the last ten years that there have been I think it's now four systematic reviews and meta analyzes. Looking at the diagnostic properties of the central vein sign. And, you know, it turns out that when you look at people with MS, most of them have a pretty high proportion of white matter lesions that have visible central veins. And there's a lot of questions about, you know, how to best use the central vein sign. But when 40% or more of the white matter lesions that you see have visible central veins, then the likelihood of a diagnosis of MS is very high. So, this is why we're so excited about it in the MS field because it's a really useful diagnostic tool. You know, again when you have appropriate ion sensitive sequences, if you see someone with white matter lesions and you see that 40% or more of them have visible central veins, this tells you that this person very likely has MS.  Dr Albin: So, Dr Oh, I hear you say, you know, 40% of the lesions. Does that mean the neuro radiologist needs to look at every single lesion and then count how many have the central veins, or is there an easier way to do this? Dr Oh: Great question. Casey, there is definitely an easier way because our neuro radiologists would not be our friends anymore if we made them look at every white matter lesion and make sure that 40% of them had the central vein sign. So, because it's so time-consuming to use that 40% threshold, there's an easier criterion that has actually made it into the diagnostic criteria. And it's called Select Six. And what this means is when you have more than ten lesions, as long as you show that six of them have a visible central vein, you just have to count six with the central vein. Then you're done. So that means you're Select Six positive or central veins nine positive. However, if you have ten or fewer lesions, as long as you show that more than 50% of them show a visible central vein, then you are select six positive, and then you're done. So, as you can see, it's a much simpler criterion to apply, and it seems to perform almost as well as that 40% threshold, which is why that is the criterion that's made it into the new diagnostic criteria.  Dr Albin: Perfect. I love that we definitely do not want to make enemies with our neuro radiology colleagues, but yet they do so much for us. So perfect. I'm glad that we can, make their jobs a little easier without losing any specificity there, or just losing a touch of specificity there. All right. If I am working with a, you know, in a center that maybe doesn't do this all the time, am I just getting a run of the mill SWI sequence? Do I need to ask my radiologist for a special sequence? Or is this just, you know, you can get it from the typical array of what our patients are getting.  Dr Oh: You know, SWI is a widely available commercial sequence that's iron-sensitive, the ones that are typically commercially available, they can detect central veins, but there actually are little tweaks that you can do to make it a little more optimal. With the recent diagnostic criteria publication, which was, led by Xavier Montalban and recently published in Lancet Neurology. There's actually a companion MRI paper that was led by Frederick Barkov and Danny Wright. And the reason I'm specifically citing those papers is in that companion MRI paper, there's a table that has kind of optimal sequence parameters that you can use even with a conventional SWI sequence, to try to best detect the central vein sign. And then there's a wide range of different iron-sensitive sequences, and SWI is one of them, but the one that seems to have emerged as most sensitive to detect the central vein sign is something called the 3D T2*-EPI sequence. But the bottom line is there's a whole bunch of different iron-sensitive sequences that you can use, little tweaks that you can do to make them optimal, to be able to visualize central veins when they're present within white matter lesions. Dr Albin: Incredible. So like partner with your neuro radiologist, there is a great sounds like a field guide almost to this. So, it makes it easy to pick up in your standard of care so that you can make sure that you are detecting them at the optimal level to see that more specific diagnostic biomarker.  Dr Oh: Yes. And you know, in contrast to what we were talking about with cortical lesions, you can actually detect central veins when you use these iron-sensitive sequences at any field magnet. So even at 1.5 Tesla, particularly when you use contrast, which is often given with the diagnostic scan anyway, you can very easily detect a central vein. So that's a huge benefit because it allows for widespread use. As long as you work with your radiologist to get the right iron-sensitive sequences in.  Dr Albin: Yeah, that's incredible. I mean, I think that it really will be practice-changing. And then the last one that I think was honestly new to me, I feel like I had heard a lot about the central vein sign, but the whole new to me term was this paramagnetic rim lesion. So, what does that tell us about the underlying biology of MS? And are there any other things that might also have this finding that we should sort of be aware of? And how specific is it?  Dr Oh: You know, the central vein sign is kind of the main, really new imaging measure that's made it into every part of the MS diagnostic criteria. And then together with that paramagnetic rim lesions or we call them PRL or pearls for short, they've made it as well, but in a much more limited way only because there's not as much evidence that has accumulated over time to support the diagnostic utility of pearls. But first of all, what are pearls? So, people in the MS field are really excited about pearls, because we know that they capture a subset of what we call chronic active lesions. So, MS lesions will form acutely and over time, some of them will become inactive. And then some of them are chronic active lesions, meaning that they have this rim of activated microglia around them. Over time, they continue to slowly expand. And it's almost like this slow burn. And the reason why we focus a lot on chronic active lesions is because we know that they're a driver of progressive disease biology and MS, meaning that in people who have progressive MS or who have pretty severe disability, global disability or cognitive disability, we know that they have a high burden of pearls. And so that's why there's so much excitement in MS about being able to image chronic active lesions. It's because we're always looking for an imaging measure that allows us to accurately predict progression or to, measure progression over time. So that's why there's so much excitement in MS about pearls. But as kind of an added bonus, it turns out pearls are also really specific for MS. And so, when you use the same iron-sensitive sequences, by the way, that's used to detect the central vein sign when you use appropriate iron‑sensitive sequence. And if you see that someone has a pearl, the likelihood of a diagnosis of MS is very high. The one exception to that is Susac syndrome, where pearls have been observed. But other than that, with many other white matter diseases like neuro rheumatology disease, NMOSD, MOGAD, you really don't see pearls. And so, this is why it's made it into the new diagnostic criteria. In contrast to the central vein sign, though, not everybody with MS has a pearl, so the sensitivity isn't as high. However, it's really, really specific in the range of, you know, 90 to 95%. So, this is why it's been added as, an imaging measure in certain settings. It can help facilitate a diagnosis. But the real utility, again, is when you use it, it helps you to prevent misdiagnosis.  Dr Albin: It's fantastic. And hearing you talk about that, this one stands out to me as a biomarker that not only helps increase our diagnostic specificity, but also may really inform if the patient has having progression despite the treatment they're on, that this could play a role in helping you say, look, there probably is something that we need to switch because we can still see this ongoing progression. Dr Oh: Yes. And especially in this new era of treatment in MS. I think, you know, MS as a field, we've been so fortunate to have so many treatments emerge over the years that mainly target relapsing disease. But we hopefully, in the next little while, in short order, I hope we'll have treatments that target these progressive disease biologies. And so, not only is it helpful as a diagnostic marker, but there's a lot of evidence accumulating, showing that it may have a lot of prognostic value and will also help guide treatment decisions, exactly as you said.  Dr Albin: It truly does sound like it's a great time to be an MS doctor there. So, so many new advances in the field. There is so much more that we can do for these patients in our limited time left. I'd love to ask you, what is it that you're most excited about now with the change in the biomarkers, the change in the treatment, what makes you really excited to be a doctor specializing in MS right now? Dr Oh: I feel like we're on the brink of a new era of treatment. I think, you know, in the last two decades, MS care has changed so dramatically. I remember, you know, way back when, as a medical student, when I did my first neurology elective, this was when the first treatments for MS were emerging. And the prognosis that we were talking to patients about at that time is like night and day compared to what we talk to them about now. But we're going to do even better in the next couple of years. And so, there's a number of new treatments that hopefully will be approved soon that, for the first time, have shown an effect in clinical trials where it seems to be decreasing progression that is independent of relapsing activity. And that's really the greatest unmet treatment need that we have. And it seems like we might have some therapies on the horizon that can actually target that aspect of progression. It's really exciting, and even more that we're going to be able to do for our patients to completely change the way, we look at and the way we treat MS in the years to come.  Dr Albin: Dr Oh, this has just been fantastic. To all of our listeners, I really want to point you to the article because obviously, as an imaging biomarker article, there are so many beautiful images. There are great examples. There are some fantastic cases that show how applying these new biomarkers can help get you to the right diagnosis. This is truly a tour de force of how imaging has really shifted the care that we provide patients with MS, and so please go and check it out. It is one that you do not want to miss. And again, today I've been interviewing Dr Jiwon Oh about her article on diagnostic neuroimaging biomarkers for multiple sclerosis, which appears in the April 2026 Continuum issue on multiple sclerosis. Thank you again, Dr Oh, this has just been such a delight.  Dr Oh: Thank you for having me on the show, Casey, and look forward to people reading the article. Dr Monteith: This is Dr Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Today on The Creep-Off, Karl & Vinnie celebrate the least necessary holiday of all time St. Patrick's Day by searching for the biggest creep in Ireland. Plus, one of the scariest cop cams we've seen yet, featuring two children on their way to commit murder, and the latest updates from the world of scumbags. Don't forget to vote for who brought the biggest creep at patreon.com/thecreepoff.  Check out this week's scum parade stories here: Head priest of Trinity Episcopal Church in Pittsburgh accused of stealing over $1K in baseball cards from WalmartSix killed in Swiss bus fire after man reportedly set himself alight - SWI swissinfo.chBrisbane youth advocate Cody Schaeffer sentenced for assaults | news.com.au — Australia's leading news site for latest headlinesTexas Mother Sentenced to Life for Throwing Toddler from Hotel BalconyThe score is currently Vinnie 3 - Karl 3 – Guest 4 Want more of the madness? Support the show on Patreon, Supercast to snag exclusive merch and get an extra bonus episode every week!Don't forget you can leave us a voicemail at 585-371-8108You can follow our results girl Mahalia @mahellllyeahYou can follow our Results girl Danni on Instagram @Danni_Desolation

New data shows wool sales are still up in the South Island. PGG Wrightson South Island auction manager Dave Burridge said exporter demand remains highly competitive - with the SWI lifting a further 47 cents. The Country's Jamie Mackay explained further. LISTEN ABOVESee omnystudio.com/listener for privacy information.

Send us a textJoin host, Jo Fahy, and pharmaceuticals and healthcare reporter, Jessica Davis Pluss, to weigh up the forces shaping pharma in 2026. From AI's real gains in clinics and labs, to the case for inclusive data, we also discuss the politics of who funds innovation, and why rare diseases and antibiotics deserve our focus. SWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Send us a textHow did longevity go from a social media trend to a focus of serious science?In this special bonus episode our host, Jo Fahy, is joined in the studio by pharmaceuticals and healthcare reporter, Jessica Davis Pluss. We trace how Switzerland was uniquely positioned to become a global hub for healthier ageing. We also compare lifespan and health span, examine why access to clinics is so tightly guarded, and discuss why the pharmaceutical industry is moving cautiously in this growing field.SWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Shannon and Mary revisit the topic of Structured Word Inquiry (SWI) and discuss the importance of understanding the deliberate reasons for English spellings with guests Jennifer Petrich and Bradley Johnson.The conversation follows the hosts' and guests' experiences with SWI, detailing how it helps students understand and apply the structure of English spelling with its focus on word structures, etymology, and morphology. Emphasizing a shift from a phonics-only approach to one that also prioritizes morphology & etymology, the episode highlights the importance of starting with word meaning and developing scientific inquiry skills in literacy teaching. The journey into SWI is one of discovery, collaboration, & continuous learning. With the tools and strategies shared, educators can confidently embark on this path, helping their students gain a deeper understanding of the rich tapestry that is the English language. Join the conversation and dive into the world of SWI. Whether you're an educator, a parent, or a lifelong learner, there's always more to uncover in the fascinating study of words.01:01 Welcome to the RTL01:44 Introduction to SWI03:11 Meet the Guests: Jennifer Petrich and Bradley Johnson04:25 Jennifer's Journey with Dyslexia and SWI07:10 Bradley's Path to SWI12:14 Explaining SWI to Teachers21:59 Importance of Meaning & Morphology34:25 Importance of Lifelong Learning35:01 Introducing SWI35:34 Overcoming the Fear of Not Knowing36:12 Utilizing Curricular Modules and Materials37:26 Inquiry-Based Learning in the Classroom38:26 Developing Content Knowledge and Pedagogical Skills40:33 The Role of Big Ideas in Teaching42:43 Practical Applications and Teacher Experiences43:18 Scientific Inquiry in Word Study44:09 Integrating Phonics & Morphology54:17 The Importance of Community & Collaboration59:02 Final Thoughts & ResourcesRECOMMENDED RESOURCES RELEVANT TO THE EPISODE:The Literacy Doctor websiteOne Step Now EducationDyslexia Training InstitutePete Bowers's websiteOur Season 7 episode with Dr. Peter Bowers about SWIThe High Frequency Word Project book by Rebecca Loveless & Fiona Hamilton *Amazon affiliate linkThe Literacy Doctor weekly drop-ins (on Wed. )Investigating English Spelling by Bradley Johnson and Jennifer Petrich *Amazon affiliate linkStructured Word Inquiry in the Classroom (FB group)Marie Foley's courseSupport the show Get Literacy Support through our Patreon Bonus Episodes access through your podcast app Bonus episodes access through Patreon Buy us a coffee Get a FREE Green Chef box using our link

Vi tager endnu en runde med universelt stof! Hvad sker der i rummet lige for tiden?1: 3I/Atlas2: Sten fra Mars3: Temporary Moon4: Sattelite made out of wood5: Starship 6: Store tal7: Enhederne meter og sekund-----------------------------------1: 3I/AtlasNASA deler første fotos af 3I/ATLAS: Ikke rumvæsenerhttps://videnskab.dk/rummet/nasa-deler-foerste-fotos-af-3i-atlas-ikke-rumvaesener/NASA press release 19.11.25:ESA:https://www.esa.int/ESA_Multimedia/Images/2025/12/Comet_3I_ATLAS_shows_activity_in_Juice_navigation_camera_teaserESA - Comet 3I/ATLAS shows activity in Juice navigation camera teaserDuring November 2025, ESA's Jupiter Icy Moons Explorer (Juice) used five of its science instruments to observe 3I/ATLAS. The instruments collected information about how the comet is behaving and what it is made of.In addition, Juice snapped the comet with its onboard Navigation Camera (NavCam), designed not as a high-resolution science camera, but to help Juice navigate Jupiter's icy moons following arrival in 2031.Though the data from the science instruments won't arrive on Earth until February 2026, our Juice team couldn't wait that long. They decided to try downloading just a quarter of a single NavCam image to see what was in store for them. The very clearly visible comet, surrounded by signs of activity, surprised them.Not only do we clearly see the glowing halo of gas surrounding the comet known as its coma, we also see a hint of two tails. The comet's ‘plasma tail' – made up of electrically charged gas, stretches out towards the top of the frame. We may also be able to see a fainter ‘dust tail' – made up of tiny solid particles – stretching to the lower left of the frame.The image was taken on 2 November 2025, during Juice's first slot for observing 3I/ATLAS. It was two days before Juice's closest approach to the comet, which occurred on 4 November at a distance of about 66 million km.We expect to receive the data from the five scientific instruments switched on during the observations – JANUS, MAJIS, UVS, SWI and PEP – on 18 and 20 February 2026. The delay is because Juice is currently using its main high-gain antenna as a heat shield to protect it from the Sun, leaving its smaller medium-gain antenna to send data back to Earth at a much lower rate.Though Juice was further from 3I/ATLAS than our Mars orbiters were back in October, it observed 3I/ATLAS just after the comet's closest approach to the Sun, meaning that it was in a more active state. We expect to see clearer signs of this activity in the data from the science instruments. This includes not only images from JANUS – Juice's high-resolution optical camera – but also spectrometry data from MAJIS and UVS, composition data from SWI, and particle data from PEP.ESA - ESA's ExoMars and Mars Express observe comet 3I/ATLASWe have an update on 3I/ATLAS! Until September, figuring out the location and trajectory of 3I/ATLAS relied on Earth-based telescopes. Then between 1 and 7 October, our ExoMars TGO turned its eyes towards the interstellar comet from its orbit around Mars. The comet passed relatively close to Mars, approaching to about 29 million km during its closest phase on 3 October.The Mars probe observed the comet from a new viewing angle. The triangulation of its data with data from Earth helped to make the comet's predicted path much more accurate. The result was an impressive ten-fold leap in accuracy, reducing the uncertainty of the object's location.Because 3I/ATLAS is passing through our Solar System fast, travelling with speeds up to 250 000 km/h, it will soon vanish into interstellar space, never to return.The comet is currently being observed with our Juice spacecraft. Though Juice is farther from 3I/ATLAS than the Mars orbiters were last month, it is seeing the comet just after its closest approach to the Sun, when it is in a more active state. We don't expect to receive data from Juice's observations until February 2026. Komet Kalender:--------------2: Sten fra Mars:https://www.sciencealert.com/curiosity-cracked-open-a-rock-on-mars-and-revealed-a-big-surpriseCuriosity Cracked Open a Rock on Mars And Revealed a Big Surprise : ScienceAlerthttps://phys.org/news/2025-12-evidence-driven-climate-mars-jezero.htmlEvidence of rain-driven climate on Mars found in bleached rocks scattered in Jezero crater--------------------------3: Temporary MoonEarth currently has a temporary moon, an asteroid designated 2025 PN7, that is in a quasi-satellite orbit. It is not permanently bound to Earth like the main Moon, but rather shares Earth's orbit around the Sun, occasionally entering our planet's gravitational influence for several decades before drifting away again. Earth has had other temporary "mini-moons" in the past, and this is not expected to be the last. About 2025 PN7 : Size: The asteroid is between 18 to 36 meters wide, or about the size of a building. Orbit: It orbits the Sun but has been temporarily captured by Earth's gravity and is expected to remain a quasi-moon until about 2083.Distance: It does not get as close as the regular Moon, swinging between 4 and 17 million kilometers away from Earth (Moon is 384400 km away, so between 10 and 44 Lunar distances)2025 PN7 - Wikipedia https://en.wikipedia.org/wiki/2025_PN7---------------------------4: Satelite made out of wood:https://www.esa.int/Enabling_Support/Space_Engineering_Technology/ESA_flying_payloads_on_wooden_satellite----------------------------------5: Starship A: can get us really fast to Uranus:https://phys.org/news/2025-10-starship-uranus.html—————-B: Starship og kapløb med Kinahttps://videnskab.dk/rummet/starship-10-opsendt-med-succes-alligevel-faar-usa-svaert-ved-at-naa-til-maanen-foer-kina/ ældre artikel:https://videnskab.dk/rummet/spacex-raketten-starship-10-er-eksploderet-faar-store-konsekvenser-for-amerikansk-maanelanding/?utm_medium=email&utm_source=vores-nyhedsbrev----6: Store talFor at forstå store tal er det nogen gange meget godt at omregne det til noget andet. 1 * 10^6 sekunder = 11.5 dage1 * 10^9 sekunder= 31.7 år1 * 10^12 sekunder = 31 710 årSå kan vi måske forstå hvor meget forskel der er på en millonær og en millardær. Trillionær burde ikke eksistere. -----------------7: Enhederne meter og sekund Generelt kom jeg til at tænke på enheder. Meter: Historical definition:Historically, a meter was defined as one ten-millionth of the distance from the North Pole to the equator along the Prime Meridian.In 1960 the metre was thus defined in the SI system as equal to 1,650,763.73 wavelengths of the orange-red line in the spectrum of the krypton-86 atom in a vacuum.It is currently defined as the distance light travels in a vacuum in (1/299,792,458) of a second.Second:A second is the base unit of time in the International System of Units (SI), defined as the time it takes for a cesium-133 atom to undergo 9,192,631,770 hyperfine transitions in its ground state when oscillating at a specific microwave frequency.This precise atomic definition provides a universal standard for time, making it a fixed and consistent unit for the entire world, unlike older definitions based on Earth's rotation which can fluctuate. A second can also refer to an ordinal number meaning "after first" The old definition of a second was of a mean solar day. This definition was used until the mid-20th century, when it was replaced because the Earth's rotation is not constant, making the length of a solar day slightly variable. An earlier, less formal definition was based on dividing the hour into 60 parts, each of which was called a "minute," and then dividing that into 60 parts to get a "second," as the ancient Babylonians originally did(Rabbit hole: The Babylonian number system was a sexagesimal (base-60) system that used only two symbols: a vertical wedge for one (1) and a corner wedge for ten (10). It was a positional system where the value of a symbol depended on its position, with each place representing a power of 60, similar to how our base-10 system uses powers of 10. The system lacked a true zero for a placeholder initially, creating ambiguity, but later added a symbol for this purpose. )Min pointe: Vores m og s var (er) defineret efter jorden og vores omløb. Enheden m/s er derfor Jordens enhed.Lysets hastighed i vacuum er en universel konstant, men en Alien vil 100% have en anden enhed end os. Også selvom at vi har fundet bedre naturkonstanter til at definere m og s ud fra.

Send us a textAlzheimer's disease is more than age-related memory loss—it's a serious brain disorder. In this episode of the Swiss Connection Science podcast, Swissinfo healthcare reporter Jessica Davis Pluess explores the science, hope, and controversy surrounding new Alzheimer's drugs like Leqembi and Kisunla. With billions invested and global regulatory decisions diverging, what do these treatments mean for patients and healthcare systems? Visit SWI swissinfo.ch for more on this topic and a video on this story. Please come to SWI swissinfo.ch for more of our science stories from Switzerland.Journalist: Jessica Davis PlüssHost: Jo FahyAudio editor/video journalist: Michele AndinaDistribution and Marketing: Xin ZhangSWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Send us a textThe search for the elixir of life has been going on since time immemorial – and Switzerland has played a key role. Although scientists have yet to come up with a winning formula, the Alpine nation has a booming market for treatments, pills and gadgets that claim to slow ageing and help us live healthier, longer lives.Visit SWI swissinfo.ch for more on this topic and a video on this story. Please come to SWI swissinfo.ch for more of our science stories from Switzerland.Jounalist: Jessica Davis PlüssHost: Jo FahyAudio editor/video journalist: Michele AndinaDistribution and Marketing: Xin ZhangSWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Bis zu 23 Milliarden US-Dollar mehr Eigenkapital soll die UBS halten, so will es der Bundesrat. Doch würden höhere Eigenkapital-Anforderungen überhaupt etwas bringen? Und wie könnte man die UBS notfalls in einen geordneten Konkurs schicken? | Es geht um viel bei der neuen Bankenregulierung: Allein die Abschaffung des sogenannten «Double Leveraging»  – also die 100-prozentige Unterlegung von ausländischen Tochtergesellschaften mit Eigenkapital im Stammhaus – würde die Kapitalkosten der UBS um jährlich bis zu 1.3 Milliarden US-Dollar erhöhen. Das sagt ein Gutachten, das im Auftrag der Landesregierung erstellt wurde. | Lohnt es sich unter diesen Umständen überhaupt noch für die UBS, in der Schweiz zu bleiben? Was braucht es, damit die UBS im Notfall geordnet Konkurs gehen könnte? Und welche neuen Instrumente braucht die Finanzmarktaufsicht? Diese Fragen diskutieren im Geldcast-Live-Event der Denkfabrik «Foraus» und SWI swissinfo.ch: Yvan Lengwiler, Makroökonomie-Professor an der Universität Basel, und Pascal Bührig, Ökonom und Policy Fellow bei «Foraus». www.fabiocanetg.ch Der Schweizer Wirtschaftspodcast mit den hochkarätigsten Gästen! Von Börsen und Bitcoin bis Kaufkraft und Zinsen: Fabio Canetg, Geldökonom und Journalist, diskutiert im Geldcast mit seinen Gästen aus Wirtschaft, Politik und Wissenschaft über deren Werdegang, über die aktuellsten Themen aus der Finanzwelt, über die Geldpolitik der Schweizerischen Nationalbank und über die Wirtschaftspolitik von Bundesrat und Parlament. Ein Podcast über Zentralbanken, Inflation, Schulden und Geld – verständlich und unterhaltsam für alle, die auf dem Laufenden bleiben wollen. Stichworte: Bankenregulierung, Banken, UBS, Eigenkapital, Eigenmittel, Sergio Ermotti, Double Leveraging, Stammhaus, Finanzmarktaufsicht, Finma, Abwicklung, TBTF, too-big-to-fail, Yvan Lengwiler, Pascal Bührig

#FenceFam You're in for a real treat! You know him! You love him! It's Dan Olson of SWI and the ever so popular SWI YouTube channel! Listen in as we talk everything from fence to YT to Mark and Alan and AFA U where he and I are co-teaching the wood discipline!!!    Sign Up for AFA University Here: https://www.americanfenceassociation.com/events/afa_university_fence_installation_school/275/   Everything FenceTech Here: https://www.americanfenceassociation.com/fencetech/2026/   Cheers! Remember to like, share, comment and REVIEW!   The Fence Industry Podcast Links: IG @TheFenceIndustryPodcast FB @TheFenceIndustryPodcastWithDanWheeler TikTok @TheFenceIndustryPodcast YouTube @TheFenceIndustryPodcastWithDanWheeler Visit TheFenceIndustryPodcast.com Email TheFenceIndustryPodcast@gmail.com Mr. Fence Companies:    IG @MrFenceAcademy FB @MrFenceAcademy TikTok @MrFenceAcademy YouTube @MrFenceAcademy Mr. Fence Tools https://mrfencetools.com Mr. Fence Academy https://mrfenceacademy.com   Gopherwood & Expert Stain and Seal IG @stainandsealexperts  FB @ExpertProfessionalWoodCare YouTube @Stain&SealExperts  FB Group Stain and Seal Expert's Staining University  Visit RealGoodStain.com Visit Gopherwood.us   Log Cabin Fence IG @Log_Cabin_Fence FB @LogCabinFence Visit LogCabinFence.com   Elite Technique Visit getelitetechnique.com   Greenwood Fence Visit greenwoodfence.com   FenceNews Visit fencenews.com   Ozark Fence & Supply promo code: TFIP15 for 15% off! Visit ozfence.com   Benji with CleverFox for all your FENCE website needs! Visit cleverfox.online     Stockade Staple Guns Visit stockade.com   Bullet Fence Systems Visit bulletfence.com   ZPost Metal Fence Posts Visit metalfencepost.com

Send us a textWe've received the sad news that former CERN director and experimental physicist Herwig Schopper has passed away at the age of 101. He was considered the grandfather of the world's most powerful particle accelerator, helped promote peace through a Middle Eastern science hub, and voiced his concerns about the Nobel Prize. In 2024, just before his 100th birthday, we had the chance to visit him at his home on Lake Geneva. We spoke with him about some of the highlights of his career and his personal thoughts on research and its potential to contribute to peacebuilding.SWI swissinfo.ch is a public service media company based in Bern, Switzerland.

The GM of PGG Wrightson Wool. The market continued to ease at yesterday’s North Island wool sale, though the rate of decline has slowed - SWI down 5 cents.See omnystudio.com/listener for privacy information.

This episode features three renowned communicators of science who work to inform, educate and inspire the public about health issues. Microbiologist Natalia Pasternak has become one of the leading communicators of science in Brazil and internationally. As founder of Instituto Questão de Ciência, she offers advice on how others can set up science communication institutes in their countries.  Imogen Foulkes reflects upon how scientists can better communicate their research to the public, given her experience as a journalist with the BBC News and SWI swissinfo.ch based in Geneva. And Sonia Lowman of International Medical Corps highlights the power of film to connect audiences to global health issues and create a vision for the way forward.Host Garry Aslanyan speaks with the following guests:Natalia Pasternak – Founder, Instituto Questão de Ciência in BrazilImogen Foulkes - Geneva correspondent, BBC News and SWI swissinfo.chSonia Lowman -  Filmmaker and Senior Communications Specialist, International Medial CorpsDisclaimer: The views, information, or opinions expressed during the Global Health Matters podcast series are solely those of the individuals involved and do not necessarily represent those of TDR or the World Health Organization.Related episode documents, transcripts and other information can be found on our website.Subscribe to the Global Health Matters podcast newsletter.  Follow us for updates:@TDRnews on XTDR on LinkedIn@ghm_podcast on Instagram@ghm-podcast.bsky.social on Bluesky Disclaimer: The views, information, or opinions expressed during the Global Health Matters podcast series are solely those of the individuals involved and do not necessarily represent those of TDR or the World Health Organization.  The CC BY-NC-SA 3.0 IGO creative commons licence allows users to freely copy, reproduce, reprint, distribute, translate and adapt the work for non-commercial purposes, provided TDR is acknowledged as the source and adapted material is issued under the same licensing terms using the following suggested citation: Global Health Matters. Geneva: TDR; 2021. Licence: CC BY-NC-SA 3.0 IGO.All content © 2025 Global Health Matters.

1. War/Numbness (29 August 1992 - Seattle, WA) | 2. Virginia (8 October 2002 - Hamburg, GER) | 3. Sweet Sangria (4 August 2003 - Phoenix, AZ) | 4. Liquid Diamonds (23 June 1998 - Frankfurt, GER) | 5. Siren (13 June 2007 - Copenhagen, DEN) | 6. Tear In Your Hand (15 September 1999 - Milwaukee, WI) | 7. 1000 Oceans (31 May 2014 - Zurich, SWI) | 8. Icicle (2 April 1994 - Montreal, QUE) | 9. Improv/Graveyard (22 October 2011 - Copenhagen, DEN) | 10. Precious Things (15 August 2009 - Philadelphia, PA)

Send us a textDr. Pete Bowers shared how Structured Word Inquiry (SWI) transforms spelling and vocabulary into tools for deep thinking - perfect for engaging advanced and struggling readers in the elementary reading classroom. We encourage the listeners to also check out this episode on YouTube to learn from the visuals Dr. Bowers shared during the discussion (link is at the top of the show notes).RESOURCES MENTIONED DURING THE EPISODE:Our Youtube link to the episodePete Bower's Word Works Kingston website:  See MANY helpful links at the bottom of the page.   We use this homepage as a hub for SWI information.Dr. Bowers' Monday 5 pm EST office hours linkReal Spelling ToolboxActive View of Reading Duke, Cartwright, 2021Homophone Principle - described in this lessonDavid Share:  Self teaching "Ultra-detailed brain map shows neurons that encode words' meaning" Nature 631, 264 (2024)Spelling Out Orthography demonstration video from Dr. BowersDocument describing a SWI hunt for all the jobs of the final, non-syllabic Video from Dr. Bowers with Marie Foley about The Nested Combinatorial Nature of English Spelling2025 Reading League  presentation from Dr. Bowers about Morphological Instruction and Language ComprehensionUpcoming SWI Training in June 2025 with Pete Bowers and Rebecca LovelessUpcoming 4 day in-person training with Dr. Bowers in July 2025 on Wolfe IslandStructured Word Inquiry: An Implementation Guide for Teachers by Jennifer A Constantine and Kara B Lee *Amazon affiliate linkTeaching How the Written Word Works by Peter Bowers (via www.wvced.com Store)Bonus Episodes access through your podcast appBonus episodes access through PatreonFree Rubrics Guide created by usFinding Good Books Guide created by usInformation about our Patreon membershipSupport the showGet Literacy Support through our Patreon

1. Crucify (1 August 2008 - Dranouter, BEL) 2. Butterfly (13 October 2001 - Philadelphia, PA) 3. Marianne (21 July 1996 - Portland, OR) 4. Take to the Sky (12 June 2005 - Brussels, BEL) 5. Bachelorette (31 May 2014 - Zurich, SWI) 6. Suede (17 November 2017 - Austin, TX) 7. Professional Widow (29 October 1999 - London, ENG) 8. Beauty of Speed (14 July 2010 - Zurich, SWI) 9. Barons of Suburbia (17 September 2005 - Los Angeles, CA) 10. Roosterspur Bridge (10 March 2013 - Caprices, SWI) 11. Improv (16 November 2002 - Wallingford, CT) 12. Mad World (2 September 2005 - Austin, TX) 13. A Case of You (29 July 1994 - Raleigh, NC) 14. Spring Haze (6 October 2001 - Washington, DC) 15. Girl (29 November 2107 - Mesa, AZ) 16. A Sorta Fairytale (27 September 2017 - Essen, GER) 17. In Your Room (5 August 2014 - Chicago, IL)

Send us a textOn Inside Geneva this week, aid agencies count the costs of funding cuts. “I am most sad for all the millions of people living with HIV and affected by HIV whose lives have been upended. They have lost access to life-saving medication. They have showed up at clinics for support, only to find no one there to help them,” says Angeli Achrekar, Deputy Executive Director for the Programme Branch at the Joint United Nations (UN) Programme on HIV/AIDS (UNAIDS). The cuts are hitting women and girls especially hard.“Right now, a woman dies from a preventable form of maternal mortality every two minutes. That's unacceptable. One of the grants that the United States has just cut supports the training and salaries of midwives,” says Sarah Craven, Director of the Washington Office of UNFPA, the UN Population Fund. What will happen to local NGOs in crisis zones that relied on UN support?“I have to have hope. I am the leader of the Sudanese Red Crescent Society. I have staff and 12,000 volunteers behind me. So, I always have to be really strong and give hope to everyone to continue serving Sudan,” says Aida Al-Sayed Abdullah, Secretary General of the Sudanese Red Crescent Society.But could the cuts bring much-needed reform?“Sure, the humanitarian system isn't perfect. It can be inefficient and a little bit colonialistic at times. But it was delivering results. We were seeing actual progress. Now, in just a few months, decades of progress will be erased,” says Dorian Burkhalter, SWI swissinfo.ch journalist.Or will the cuts cost lives and cause more crisis?“We're so close to ending AIDS, full stop. Now, we could very well be turning back completely. All those years of work, dedication and progress,” says Achrekar.Get in touch! Email us at insidegeneva@swissinfo.ch Twitter: @ImogenFoulkes and @swissinfo_en Thank you for listening! If you like what we do, please leave a review or subscribe to our newsletter. For more stories on the international Geneva please visit www.swissinfo.ch/Host: Imogen FoulkesProduction assitant: Claire-Marie GermainDistribution: Sara PasinoMarketing: Xin Zhang

Send us a textThis is the final episode of 'Lost Cells', a short investigative podcast series. The production is an original SWI swissinfo.ch trilingual podcast made in collaboration with Piz Gloria Productions, Futur Proche, and Studio Ochenta.This gripping investigative podcast series has been uncovering the human stories behind the promises and failures of private stem cell banking in Switzerland.In our series finale, the Lost Cells team digs deeper into the international standards of the cord blood banking industry. Antoine confronts the Swiss authorities for answers. Tatiana and Ratko vow to go public and warn parents all over the world with everything they've learned about cord blood banking.SWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Send us a textOver the next two episodes, we're proud to present 'Lost Cells', a short investigative podcast series. The production is an original SWI swissinfo.ch trilingual podcast made in collaboration with Piz Gloria Productions, Futur Proche, and Studio Ochenta.This gripping investigative podcast series uncovers the human stories behind the promises and failures of private stem cell banking in Switzerland.In episode five, families across Europe feel like they're being held hostage. Who owns their cells? Do they have any rights? They fight back with the only thing they do have: their own tenacity and an international network of sleuths.SWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Send us a textLink to our website:https://theliteracyview.com/Link to our professional services:https://theliteracyview.com/services/Link to our merch store:https://logosgreenwich.com/literacyview/shop/homeJoin our Facebook Community:https://www.facebook.com/share/g/1Xe5nExhVX/?mibextid=wwXIfrPlease also write us a great review! https://podcasts.apple.com/us/podcast/the-literacy-view/id1614519794 ❤️❤️❤️The One About…Takeaway Tuesdays on Morphology and Spelling with Sue HeglandSee The Literacy View Episodes for more information about what is discussed:Episode 109: Meta on Morphology – What Should We Do? Danielle ColenbranderEpisode 111: Phonics vs. SWI for Beginning Readers Pete BowersEpisode 118: Why is Spelling Important? Richard GentryBook:Beneath the Surface of Words: What English Spelling Reveals and Why It MattersSue Hegland Bio:Sue Scibetta Hegland is an author, educator, and frequent speaker on topics related to reading and spelling. She began her career doing research and instructional design, but her focus shifted in 2003, when she learned that one of her children is dyslexic. Trained in the Orton-Gillingham approach to literacy instruction, she has been studying and teaching about often overlooked aspects of the English orthographic system since 2014. Sue has served on the Board of Directors for the Upper Midwest Branch of the International Dyslexia Association (IDA) and on the Board of Education for the Brandon Valley School District. She is currently the Editor-in-Chief for the IDA's Fact Sheet publications and is on the Advisory Council for the Upper Midwest Branch of the IDA. Sue is the founder of the website LearningAboutSpelling.com and author of the book Beneath the Surface of Words: What English Spelling Reveals and Why It Matters.Support the showThe Literacy View is an engaging and inclusive platform encouraging respectful discussion and debate about current issues in education.

Send us a textOver the next three episodes, we're proud to present 'Lost Cells', a short investigative podcast series. The production is an original SWI swissinfo.ch trilingual podcast made in collaboration with Piz Gloria Productions, Futur Proche, and Studio Ochenta.This gripping investigative podcast series uncovers the human stories behind the promises and failures of private stem cell banking in Switzerland.In episode four, Luis Daniel, Tatiana and Ratko investigate in multiple European jurisdictions. The international band of families turns to Antoine Harari and Valeria Mazzucchi, two journalists based in Geneva, to give them the answers they can't get from a company in turmoil. Luis Daniel visits Poland looking for assurances that his daughter's stem cells can help him cure his cancer before it's too late. SWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Send us a textOver the next four episodes, we're proud to present 'Lost Cells', a short investigative podcast series. The production is an original SWI swissinfo.ch trilingual podcast made in collaboration with Piz Gloria Productions, Futur Proche, and Studio Ochenta.This gripping investigative podcast series uncovers the human stories behind the promises and failures of private stem cell banking in Switzerland.In episode three, Tatiana and Ratko prepare to move their frozen stem cells but things don't go as planned. Perhaps the company and its marketing aren't everything they've been promised? Families around Europe begin asking questions about their cells, and where and how they're being stored. Swiss authorities are alerted and arrange an inspection. What they discover sets off an international quest.SWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Subscriber-only episodeSend us a textThis is our February 2025 exclusive bonus episode of Reading Teachers Lounge podcast.  In these bonus episodes, Shannon and Mary will share about the students they're helping in reading, the resources they're using, and the books and other materials they're studying to further their practical knowledge about the Science of Reading.  We start this episode with an apology and explanation for the missing January episode and the delay in publishing this one.  (Back in January, Shannon's computer crashed unexpectedly and they lost 3 regular podcast episodes and the January bonus episode in the hard drive crash).In this February 2025 bonus episode, Shannon and Mary provide details about their tutoring students of various ages and how they're using different curriculum resources with their readers.    Mary shares how she's having courageous conversations with teachers, parents, and administrators through her advocacy work.  Shannon and Mary chat about the resources they're using with their tutoring students:  Bookworms, Morpheme Magic, Write Score Super Sentences, SWI, and Word Matrices.  Check out the links below for more information about the resources mentioned.  From Emotions to Advocacy by Peter W. D. Wright and Pamela Darr Wright *Amazon affiliate linkWrights LawWord MatricesSuper Sentences demonstration videoSuper Sentences Bookworms exampleBookworms Grade 3 Module 4: The Miraculous Journey of Edward Tulane by Kate DiCamilloWrite ScorePete Bowers' website  -lots of helpful links at the bottom of the home pageSpelling Out Orthographyfree once a week Zoom with Dr. Pete Bowers about SWI Structed Word Inquiry for Early ReadersCox Campus Structured Literacy courseGet Literacy Support through our Patreon

Send us a textOver the next five episodes, we're proud to present 'Lost Cells', a short investigative podcast series. The production is an original SWI swissinfo.ch trilingual podcast made in collaboration with Piz Gloria Productions, Futur Proche, and Studio Ochenta. This gripping investigative podcast series uncovers the human stories behind the promises and failures of private stem cell banking in Switzerland.In episode two Tatiana and her husband Ratko choose cord blood banking in Switzerland for their daughter's cells. They seek out a top US university conducting research in stem cell transplants and are offered a rare opportunity to be part of this leading-edge program.SWI swissinfo.ch is a public service media company based in Bern, Switzerland.

Send us a textOver the next six episodes, we're proud to present 'Lost Cells', a short investigative podcast series. The production is an original SWI swissinfo.ch trilingual podcast made in collaboration with Piz Gloria Productions, Futur Proche and Studio Ochenta. This gripping investigative podcast series uncovers the human stories behind the promises and failures of private stem cell banking in Switzerland.In episode one, Luis Daniel suffers from a rare type of blood cancer. Could promising stem cell research, and a baby be the chance he's been looking for? Banking his baby's cord blood offers an opportunity to secure a potential cure. He looks to a leading company based in Switzerland to help him protect himself and his family. SWI swissinfo.ch is a public service media company based in Bern Switzerland.

In this weeks episode we hear from people in the UK who have seen Large Panther/Puma type Cats. In some cases their pets were attacked and they were chased by the cats. Known as the beast of Bristol, this terrifying predator is roaming the SWI have also included some strange unexplained deaths in the area and we look at the case of the Bristol Babes in the WoodsBecome a supporter of this podcast: https://www.spreaker.com/podcast/deborah-hatswell-bbr-investigations-cryptids-paranormal-unexplained-events--2840337/support.

Send us a textThe One About…Phonics vs SWI for Beginning Readers with Peter Bowers  Quote from article:How realistic is it to introduce a method that may in fact be too complicated for teacher and student alike—and particularly problematic for beginning reading instruction? Pete Bowers Bio:Peter Bowers runs the “WordWorks Literacy Centre”consultancy that targets Structured Word Inquiry in his workwith schools, teachers, and students. https://wordworkskingston.com/WordWorks/About_WordWorks.html Video 1:The Nested Structure of English Spelling: A study in the binding power of structure and meaning - and everyday combinatoriality (Bowers & Foley, 2024)https://www.youtube.com/results?search_query=the+nested+structure+of+English+Spelling Video 2:Spelling-Out Orthography in SWI to build graphemic and morphological knowledgehttps://www.youtube.com/watch?v=fa0MVLbvBig Contact Dr. Peter Bowers peterbowers1@mac.com www.wordworksinternational.comwww.youtube.com/@WordWorksKingston The Literacy View Ep.109-Meta on Morphology! What Should We Do? with Dr. Danielle Colenbranderhttps://youtu.be/3BkGD1YCcsE?si=hTIgMkQXDo-LnulR Article:Must Phonics Fail in Order for Structured Word Inquiry to Succeed?Harriett Janetos, Reading SpecialistJanuary 8, 2025https://learningbydesign.com/professional-development/spell-links-blogue/  Support the showThe Literacy View is an engaging and inclusive platform encouraging respectful discussion and debate about current issues in education.

According to the Federation of the Swiss watch industry (FH), Switzerland produces around 15 to 20 million watches a year — which is a minuscule amount that represents around 2% of global timepiece manufacturing. However, this is a clear case of quality over quantity. This tiny nation, as reported by the news outlet SWI swissinfo, commands more than a 50% share of the global watch industry in value terms, and more than 95% of watches sold for CHF 1,000 (just over USD $1,100) or more are produced by Swiss companies. Translation: Switzerland dominates when it comes to the luxury segment of the watch market. Watch enthusiasts recognize the cachet of the Swiss-made label, and the country reigns supreme when it comes to fine timepieces. So, if Switzerland dominates the luxury watch segment, which luxury watch brands dominate within that prestigious circle? Listen to this episode to discover the top 10 luxury watch brands, as told by the numbers.If you like what you're listening to please let us know! Leave a review and subscribe to the podcast for daily updates!To shop our watches, visit www.LuxuryBazaar.com Follow us on YouTube at https://www.youtube.com/@greymarketpodFOLLOW ON INSTAGRAM:Grey Market Podcast - https://www.instagram.com/greymarketpodLuxury Bazaar - https://www.instagram.com/luxurybazaarofficialRoman Sharf - https://www.instagram.com/romansharfAdrian Taskin - https://www.instagram.com/adriantaskinAna - https://www.instagram.com/watchanna.lbAlex Serrano - https://www.instagram.com/nowaitlistKevin Boyce - https://www.instagram.com/chronokev.lbDito - https://www.instagram.com/timeproviderFOLLOW ON EVERYWHERE:Website - https://www.luxurybazaar.comGrey Market Magazine: https://www.luxurybazaar.com/grey-market/Roman Sharf YouTube - https://www.youtube.com/@romansharfLuxury Bazaar - https://www.youtube.com/@LuxuryBazaarTwitter - https://twitter.com/greymarketpod

Send us a textIn this week's Inside Geneva episode, UN correspondents in Geneva and New York look back at 2024. Dorian Burkhalter, journalist, SWI swissinfo.ch: ‘Wars everywhere, climate change, deepening inequalities, AI…it's just threats everywhere. But it just seems like the more global our problems are becoming, the weaker the UN is also becoming.' But is the biggest event of the year the US election? Nick Cumming-Bruce, contributor, New York Times: ‘It's hard to top the US election because it's already dominating the conversation on everything else that we've covered in 2024.' What could an isolationist America first strategy mean for the UN, and for the multilateral system? Dawn Clancy, UN correspondent, New York: ‘Pulling out of the Paris Agreement, or the WHO, threatening to cut funding, the US is the biggest funder of the UN, billions of dollars. So it's just going to be chaos and no leadership.' Are we on the verge of a new world order, without the guardrails of international law, or the Geneva Conventions?  Imogen Foulkes, host, Inside Geneva: ‘The world is changing, while I'm watching, in terms of our fundamental principles, the world is changing while I'm watching, and for a while I didn't even quite notice it.'  Join us on Inside Geneva for an in-depth discussion of 2024, and some predictions for 2025. Get in touch! Email us at insidegeneva@swissinfo.ch Twitter: @ImogenFoulkes and @swissinfo_en Thank you for listening! If you like what we do, please leave a review or subscribe to our newsletter. For more stories on the international Geneva please visit www.swissinfo.ch/Host: Imogen FoulkesProduction assitant: Claire-Marie GermainDistribution: Sara PasinoMarketing: Xin Zhang

Send us a textCities tend to get hotter than the countryside when a heatwave hits. What can be done about these urban heat traps? How can hot summers be made more tolerable for city dwellers? SWI swissinfo.ch asked an expert at the federal technology institute ETH Zurich.If you are interested in reading about this story or other science stories from Switzerland please visit www.swissinfo.ch/science.Jounalist: Luigi JorioHost: Jo FahyAudio editor/video journalist: Michele AndinaDistribution and Marketing: Xin ZhangSWI swissinfo.ch is a public service media company based in Bern Switzerland.

Send us a textSwiss students are propelling the future of space travel with innovative reusable rocket technology, putting Switzerland on the map in the global space race. SWI swissinfo.ch took a closer look at their projects in northern and western Switzerland. Visit SWI swissinfo.ch for more on these exciting rocket projects and a video on this story. Please come to SWI swissinfo.ch for more of our science stories from Switzerland.Jounalist: Christian RaaflaubHost: Jo FahyAudio editor/video journalist: Michele AndinaDistribution and Marketing: Xin ZhangSWI swissinfo.ch is a public service media company based in Bern Switzerland.

Send us a textUsing a new type of instrument, two astrophysicists from the University of Bern hope to get a little closer to unravelling the mystery of the solar system's origins. They believe the key to this lies in the ice that can occur in a dust layer on comets.Please visit SWI swissinfo.ch for more information about this research and a video about ice on comets. Please come to SWI swissinfo.ch for more of our science stories from Switzerland.Jounalist: Christian Raaflaub Host: Jo FahyAudio editor/video journalist: Michele AndinaDistribution and Marketing: Xin ZhangSWI swissinfo.ch is a public service media company based in Bern Switzerland.

Are you a victim or a perpetrator? ~ '97 Bonnie and Clyde (13 December 2001 - Basel, SWI)

Send us a textThe Swiss Connection Podcast is back on October 22 with six new episodes on science happening in Switzerland.SWI swissinfo.ch is a public service media company based in Bern Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience.

1. Body and Soul (3 July 2007 - London, ENG) 2. Beauty of Speed (13 December 2007 - Santa Barbara, CA) 3. Strange Little Girl (19 March 2003 - Erie, PA) 4. Cornflake Girl (19 September 1998 - San Jose, CA) 5. Caught A Lite Sneeze (14 July 2009 - San Jose, CA) 6. Glory of the 80's (20 August 1999 - Tampa, FL) 7. Bouncing off Clouds (15 June 2007 - Seinajoki, FIN) 8. Lady in Blue (13 August 2009 - NYC, NY) 9. Raining Blood (16 November 2001 - Los Angeles, CA) 10. Mountain (10 March 2013 - Caprices, SWI) 11. Upside Down (31 May 2014 - Zurich, SWI) 12. Silent All These Years (23 October 2001 - Chicago, IL) 13. Playboy Mommy (25 April 2003 - San Antonio, TX) 14. Riot Poof (7 October 1999 - Seattle, WA) 15. Lust (28 February 2003 - Albany, NY) 16. Honey (7 June 2022 - Portland, OR) 17. Precious Things (27 July 2009 - Atlanta, GA) 18. Code Red (12 October 2007 - NYC) 19. She's Your Cocaine (19 July 1998 - Chicago, IL) 20. Professional Widow (24 August 2003 - Boston, MA) 21. Big Wheel (15 August 2009 - Philadelphia, PA) 22. Only Women Bleed (3 November 2001 - Dallas, TX) 23. Girl Disappearing (24 August 2014 - Miami, FL) 24. Yes Anastasia (24 March 1996 - Frankfurt, GER) 25. Twinkle (20 September 1998 - Santa Barbara, CA)

Send us a Text Message.For artist and researcher Şerife (Sherry) Wong the popular image of visionary geniuses who change the world from their garages is an illusion. “We are idealising the myth of the inventor, the American dream of the man who, from nothing, becomes super rich and changes the world for the better, but...for whom?” asks Wong, who studies the social implications of emerging technologies. She is also an affiliate research scientist at the University of California, Berkeley.You can find more written content about this story on SWI swissinfo.ch: in English in Italian (original) in German Journalist: Sara IbrahimHost: Jo Fahy Audio editor / Video journalist: Michele Andina Distribution and Marketing: Xin ZhangSWI swissinfo.ch is a public service media company based in Bern Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience.

Send us a Text Message.In this episode, we talk to Stanford University professor Fred Turner, who's been studying the impact of new media technologies on American culture for decades. Turner is also among those most vocal in denouncing the injustices faced by people living and working in Silicon Valley.You can find more written content about this story on SWI swissinfo.ch: in English in Italian (original) in German Journalist: Sara IbrahimHost: Jo Fahy Audio editor / Video journalist: Michele Andina Distribution and Marketing: Xin ZhangSWI swissinfo.ch is a public service media company based in Bern Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience.

Send us a Text Message.Pamela Munster, a world-renowned oncologist, has been working in San Francisco for 15 years.  In this episode, she recounts her battle against breast cancer. You can find more written and video content about this story on SWI swissinfo.ch: in English in French (original) in German Journalist: Marc-André Miserez Host: Jo Fahy Audio editor/Video: Michele Andina Distribution and Marketing: Xin Zhang SWI swissinfo.ch is a public service media company based in Bern Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience.

Send us a Text Message.In this episode, SWI swissinfo.ch sat down with Claude Zellweger, Google's in-house design guru. We discussed the role of designers in tech innovation, AI, and the future of education. He also shared his thoughts on the challenges facing the tech industry and how we can overcome them by putting people first. You can find more written and video content about this story on SWI swissinfo.ch: in English in French (original) in German Journalist: Marc-André Miserez Journalist: Marc-André Miserez Host: Jo Fahy Audio editor/Video: Michele Andina Distribution and Marketing: Xin Zhang SWI swissinfo.ch is a public service media company based in Bern, Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience. SWI swissinfo.ch is a public service media company based in Bern Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience.SWI swissinfo.ch is a public service media company based in Bern Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience.

Send us a Text Message.More than 150 Swiss start-ups have received a boost from California entrepreneurship, and three of them are already worth $1 billion. This is a source of pride for Swissnex in San Francisco and its CEO, Emilia Pasquier. Hear what she has to say about Swiss innovation in this episode.  You can find more written and video content about this story on SWI swissinfo.ch: in English in French (original) in German Journalist: Marc-André Miserez Host: Jo Fahy Audio editor/Video: Michele Andina Distribution and Marketing: Xin Zhang SWI swissinfo.ch is a public service media company based in Bern, Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience. SWI swissinfo.ch is a Multilingual Public service media based in Bern, Switzerland. SWI swissinfo.ch is a public service media company based in Bern Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience.

Send us a Text Message.In his 50 years in the USA, St. Gallen psychologist and consultant Herman Gyr has never lost faith in human ingenuity, the ability to learn and adapt to even the most adverse circumstances. This is despite the fact that climate change is his biggest concern.In this exclusive interview with SWI swissinfo.ch, Gyr shared his insight into what he thinks are the key influences that drive innovation in Silicon Valley.An article and a video about this interview can be found here on SWI swissinfo.ch:in Germanin French (original)in ItalianJournalist: Marc-André MiserezHost: Jo FahyAudio editor/Video: Michele AndinaDistribution and Marketing: Xin ZhangSWI swissinfo.ch is a Multilingual Public service media based in Bern, Switzerland. SWI swissinfo.ch is a public service media company based in Bern Switzerland. It publishes independent news and information in 10 languages about Switzerland for a global audience.

Shirley discovered through DNA tests that her entire biological family was different from the one she had known all her life, leading her to become a private detective so that she could uncover her true origins. Shirley can be reached via email smunoznewsonauthor@gmail.comInstagram: shirleymunoznewson_authorFacebook: shirleymunoznewson.comResources Mentioned:Untangling Our RootsDon Anderson's Missing Pieces - NPE LifeThe Little Dark One: A True Story of Switched at Birth by Shirley Munoz-NewsonNPE Stories PatreonNPE Stories facebook pagehttps://www.facebook.com/NPEstories

The biggest news of the week, obviously, is Sony's fight to add PSN to Helldi…no, wait, it's actually Nintendo confirming the next Swi…huh, no, it's Microsoft shutting down Tango Gameworks and creating a (new) existential crisis for the Xbox brand. Phew. But Patrick, Rob, Janet, and Cado are here to unpack it all, including thoughts on Indika, Manor Lords, and Little Kitty, Big City. We also spend a shockingly long time talking about Apple's weird new iPad ad.Discussed: Microsft closes several Bethesda Studios 12:49, Sony's Helldivers' Horrible No Good Very Bad Week 55:09, Switch 2 announcement 1:10:08, The iPad Pro Ad Controversy, 1:23:04, Indika 1:47:47, Manor Lords 2:10:04, Little Kitty Big City 2:19:44, Rusty's Retirement 2:30:21, John Wick Pinball Game 2:38:44, Outro and Announcements 2:50:37See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

#FenceFam Live from the Mr. Fence Academy 2024 Retreat... Mark Olson and I sat down and talked No-Dig, SWi, haters, and how to sell your company's value!!! Listen to this goat in the fence trade drop knowledge bombs on how he got where he's at now!!!         Help Justen Meneses help out those that protect us! Let's show these guys what the FenceFam is all about!!! Venmo @turkeys4soldiers Checks to:  413 North 7th Street Plattsmouth, NE 68048   Sign up today for the Mr. Fence Academy Retreat https://www.eventbrite.com/o/mr-fence-academy-44525883583   Cheers! Remember to like, share, comment and REVIEW!   Mr. Fence Companies:  Mr. Fence https://gomrfence.com Mr. Fence Tools https://mrfencetools.com Mr. Fence Academy https://mrfenceacademy.com ...Remember to tell Shawn #TeamRed sent you!!!   Episode Links: @TheFenceIndustryPodcast @RiverCityFence1985 TheFenceIndustryPodcast@gmail.com   StainAndSealExperts.com @stainandsealexperts on IG Stain & Seal Experts on YouTube Stain and Seal Expert's Staining University on FB RealGoodStain.com   Greenwood Fence CALL LISA NOW!!! 888-24-FENCE ext #3 Tell her Dan from The Fence Industry Podcast Sent You!!! greenwoodfence.com IG @greenwood_fence FB Greenwood Fence   FenceNews Visit fencenews.com    Ozark Fence & Supply promo code: TFIP15 for 15% off! ozfence.com   Benji with CleverFox for all your FENCE website needs! cleverfox.online   Tony Thornton Fence Consulting Group fenceconsultinggroup.com   The Fence Industry Podcast is Produced by "Rob The Producer" Check him out at @therobnoble everywhere.