Podcasts about bikman

Listen Ad-Free: https://benbikman.comIn this Metabolic Classroom mini lecture, Dr. Bikman explores the powerful effects of ketones—particularly beta-hydroxybutyrate (BHB)—on the cardiovascular system. While ketones are typically thought of as a backup fuel, Ben explains how they are, in fact, an adaptive and efficient energy source that can support heart function in both healthy and failing states.Ben breaks down groundbreaking studies showing that ketones increase cardiac output, reduce vascular resistance, and improve heart function—especially in heart failure cases. He highlights the unique ability of BHB to reduce “afterload,” or the resistance the heart must pump against, effectively easing the heart's workload. He also details ketones' role in promoting vasodilation by acting on endothelial cells and smooth muscle, increasing nitric oxide and improving overall circulation.Beyond fuel metabolism, BHB also acts as a signaling molecule with epigenetic and anti-inflammatory effects. It can modulate gene expression by influencing histone acetylation and β-hydroxybutyrylation, leading to improved antioxidant defense and reduced inflammation via inhibition of the NLRP3 inflammasome—a key player in heart failure and atherosclerosis.Finally, he touches on the practical implications, suggesting both ketogenic diets and exogenous ketone supplements—particularly L-BHB—as viable strategies for enhancing cardiovascular resilience. This lecture positions ketones not just as fuel, but as potent metabolic signals capable of supporting and even restoring heart health.Show Notes/References:For complete show notes and references, we invite you to become an Insider subscriber or member. You'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, unlimited access to Dr. Bikman's Digital Mind, ad-free podcast episodes, show notes and references, and online, live Office Hours access with Ben. It also includes Ben's Weekly Research Review Podcast. Learn more: https://www.benbikman.comIMPORTANT NOTE: The information presented is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dr. Bikman is not a clinician—and, he is not your doctor. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions. Hosted on Acast. See acast.com/privacy for more information.

Listen Ad-Free: https://benbikman.comIn this mini-lecture, Ben explores the biochemical and physiological differences between plant and animal proteins—avoiding environmental or ethical debates and focusing strictly on metabolism and human health. He breaks down essential amino acids, emphasizing that animal proteins are "complete" sources, while most plant proteins fall short—particularly in leucine, which is vital for muscle protein synthesis.Dr. Bikman also discusses digestibility and bioavailability, explaining why animal proteins are more efficiently absorbed than plant sources. He introduces the DIAAS scoring system and details studies showing how much less effective plant proteins are at raising amino acid levels in the blood compared to animal proteins like pork or eggs.Importantly, the lecture addresses “antinutrients” in plant proteins—like trypsin inhibitors, phytates, and lectins—which impair protein digestion and mineral absorption. These antinutrients are also implicated in autoimmune responses, especially when intestinal permeability is compromised. Dr. Bikman explains how fermentation, soaking, and pressure cooking can help—but not eliminate—these compounds.The lecture concludes by warning about heavy metal contamination in plant-based protein powders and reminds us that while plant proteins can support health, they require more planning and carry additional nutritional burdens compared to their animal-based counterparts.Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber or member. You'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, unlimited access to Dr. Bikman's Digital Mind, ad-free podcast episodes, show notes and references, and online, live Office Hours access with Ben. It also includes Ben's Weekly Research Review Podcast, and a searchable archive. Learn more: https://www.benbikman.comIMPORTANT NOTE: The information presented is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dr. Bikman is not a clinician—and, he is not your doctor. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions. Hosted on Acast. See acast.com/privacy for more information.

In this episode of The Commune Podcast, Jeff Krasno sits down with metabolic scientist Dr. Ben Bikman to explore how insulin — one of the body's most important hormones — influences nearly every aspect of our health. From weight gain and fatigue to inflammation and chronic disease, insulin resistance lies at the root of many modern ailments. Together they break down the science of metabolism in clear, actionable terms, explaining how blood sugar, insulin, and energy regulation interact — and how diet, movement, and fasting can restore balance. This conversation offers a roadmap for reversing insulin resistance, improving metabolic flexibility, and reclaiming long-term vitality. This podcast is made possible by: Tia: Join Tia today at ⁠AskTia.com⁠ and enter promo code COMMUNE25 and get the first 3  months of your annual membership FREE. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Mimio: Get 25% off with code COMMUNE25 at Mimiohealth.com Vivobarefoot: Go to Vivobarefoot.com/commune where you'll receive 25% off Igniton: Visit igniton.com and use code Commune75 for $75 off your order of two bottles or more.

Is everything you've been told about nutrition wrong?In this explosive interview, Dr. Robert Kiltz and metabolic scientist Dr. Ben Bikman dismantle mainstream dietary advice—from the myth of “healthy carbs” to the dangers of fruit, cereal, and even modern medicine's blind spots. Discover why insulin resistance is the root of most chronic diseases, how ketogenic and carnivore diets outperform conventional approaches, and why academia may be printing “monopoly money” when it comes to health research.

If you want to improve your energy and long-term health, start by understanding how your body uses glucose.In this episode of A Whole New Level, Dr. Benjamin Bikman, scientist and author of Why We Get Sick, joins Mike Haney to unpack the science of glucose metabolism and insulin resistance—and why blood sugar isn't the whole story.Dr. Bikman explains how insulin regulates energy balance, why HbA1c is only part of the picture, and how chronic high insulin can silently drive weight gain, fatigue, and metabolic disease. He also shares practical ways to lower insulin naturally through diet, exercise, and daily habits.They discuss:Why insulin, not glucose, is the root of metabolic dysfunctionWhat HbA1c and fasting glucose really tell youThe early signs of insulin resistance most people missHow muscle tissue protects against high glucose and insulinWhy low-carb and intermittent fasting aren't one-size-fits-allPractical nutrition and movement strategies for better metabolic flexibilitySign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl

visit: https://www.benbikman.comvisit: https://insuliniq.com In this Metabolic Classroom lecture, Dr. Bikman explores the deep biochemical relationship between stress and ketone production, uncovering how the body interprets stress signals as cues to mobilize fat and create ketones.He explains how stress hormones—like epinephrine, cortisol, glucagon, and growth hormone—aren't just emergency signals but actually metabolic adaptation hormones that help the body shift into fat-burning mode. Through the sympathetic nervous system and hormone cascades, the body responds to stress by increasing lipolysis and triggering ketogenesis, even during fasting, exercise, or low-carb eating.Ben walks through how ketogenesis begins at the level of fat cells and liver mitochondria, and how key molecules like acetyl-CoA and oxaloacetate determine whether the body makes glucose or ketones.Importantly, he clarifies that while stress can trigger positive metabolic shifts, chronic stress without relief can lead to harmful insulin resistance. The takeaway: understanding the difference between acute and chronic stress is key to using this response to your metabolic advantage. Hosted on Acast. See acast.com/privacy for more information.

Most of us will never have our insulin levels tested, yet this single hormone is the body's master regulator of energy. When it stops working properly, almost every system in the body is affected, from how we store fat, to how we age. Today's guest is Dr Ben Bikman, a scientist and world-leading expert on insulin and metabolism. He's a Professor in the Department of Physiology and Developmental Biology at Brigham Young University (BYU) and has spent years researching how changes inside our cells lead to common metabolic disorders, such as obesity, type 2 diabetes, and dementia. He frequently publishes his research in peer-reviewed journals, speaks at scientific conferences all over the world and is the author of 2 books, Why We Get Sick and How Not to Get Sick. In this conversation, we discuss: Why insulin is the body's “master hormone”, guiding how we store and use energy and how resistance to it can cause a wide range of chronic health problems. The fact that almost 9 in 10 adults show signs of poor metabolic health, and why this is a global issue that affects countries far beyond the United States. How ethnicity and genetics shape the way we store fat, explaining why two people of the same weight and size can face very different risks of conditions like type 2 diabetes or heart disease. Why focusing only on blood glucose misses the early warning signs of poor metabolic health, and why measuring insulin levels offers a clearer and earlier picture of risk. The visible clues your body may already be giving you – such as skin tags or darker, velvety patches of skin around the neck or armpits – that can indicate chronically elevated insulin. Practical strategies to bring insulin down, from reducing refined sugars and starches to spacing out meals and experimenting with fasting in ways that work for both men and women. So often, we're told that chronic illnesses are inevitable or a natural part of ageing. But as Ben explains, many of these conditions have a common origin – and by focusing on insulin resistance, we can take powerful steps towards prevention and even reversal. This conversation is not about fear, but empowerment. It's a reminder that our everyday choices – how and what we eat, how we move, and how often we give our bodies a rest from food – can profoundly influence our future health. I hope you enjoy listening. Support the podcast and enjoy Ad-Free episodes. Try FREE for 7 days on Apple Podcasts https://apple.co/feelbetterlivemore. For other podcast platforms go to https://fblm.supercast.com.   Thanks to our sponsors: https://www.vivobarefoot.com/livemore https://thriva.co/ https://www.boncharge.com/livemore   Show notes https://drchatterjee.com/582   DISCLAIMER: The content in the podcast and on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

Insulin for beginners | disease states connected to insulin resistance | metabolism and the rise in breast cancer | PCOS | cholesterol | ED | weight loss jabs | vaping

Insulin resistance triggers everything from Alzheimer's to erectile dysfunction. Dr. Benjamin Bikman examines the metabolic crisis shared by 50% of America.Full show notes and resources can be found here: jordanharbinger.com/1201What We Discuss with Dr. Benjamin Bikman:Half of US adults have insulin resistance without knowing it. It's the upstream driver of most chronic diseases — from high blood pressure to erectile dysfunction to Alzheimer's — not just diabetes.Medical focus on blood glucose misses the real problem. Insulin levels are rarely tested, yet elevated insulin drives disease years before blood sugar becomes abnormal.Fat cell size matters more than total fat. East Asians develop insulin resistance with less weight gain because they have fewer, larger fat cells versus more, smaller ones in Europeans.Insulin resistance causes brain starvation. When neurons can't access glucose due to insulin resistance, cognition declines — which is why some in the medical community refer to Alzheimer's as "type 3 diabetes."Type 2 diabetes is reversible through carb restriction. In one study, 11 newly diagnosed patients reversed their diabetes in 90 days by eating unlimited protein and fat, just limiting carbs.And much more...And if you're still game to support us, please leave a review here — even one sentence helps! Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom!Do you even Reddit, bro? Join us at r/JordanHarbinger!This Episode Is Brought To You By Our Fine Sponsors:Cayman Jack: Explore uncharted flavor: caymanjack.comFactor: 50% off first box: factormeals.com/jordan50off, code JORDAN50OFFWayfair: Start renovating: wayfair.comHomes.com: Find your home: homes.comProgressive Insurance: Free online quote: progressive.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Metabolic Classroom, Ben explores the fascinating metabolic effects of yerba mate, a traditional South American tea that's gaining attention in scientific circles. Yerba mate contains a synergistic mix of bioactive compounds, including xanthines (like caffeine), chlorogenic acid, and saponins—all of which contribute to its wide-ranging health benefits. Dr. Bikman explains how this unique brew supports fat loss, improves mitochondrial efficiency, regulates appetite, and enhances insulin sensitivity.Drawing from human and rodent studies, the lecture highlights yerba mate's ability to increase fat oxidation, particularly when combined with exercise. It also activates AMPK, a critical energy-regulating enzyme, which promotes glucose uptake and mitochondrial biogenesis. One of the most intriguing effects of yerba mate is its stimulation of GLP-1—both directly through the gut and indirectly by modifying the gut microbiome—making it a natural, non-pharmaceutical way to enhance satiety and insulin regulation.Dr. Bikman also discusses the underappreciated role of bitter taste receptors in the body—not just on the tongue, but also in fat cells and the gut. Yerba mate interacts with these receptors to influence hormone release (like CCK and PYY) and to promote thermogenesis in brown and beige fat, offering yet another pathway for metabolic support. Finally, he shares unpublished findings from his lab showing yerba mate's impact on hepatic redox balance, adding to its reputation as a powerful metabolic ally.Ben's favorite yerba mate and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Hosted on Acast. See acast.com/privacy for more information.

Found My Fitness - Rhonda Patrick: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Get access to 130 episodes of my premium podcast, The Aliquot, as a FoundMyFitness Premium Member Insulin resistance silently shapes the trajectory of nearly every major chronic disease, yet it's often overlooked until blood sugar abnormalities become obvious. In this episode, Dr. Ben Bikman exposes the dietary culprits that drive metabolic dysfunction and highlights actionable, evidence-based tactics for improving metabolic health. Ben also addresses pressing questions about popular weight loss medications like Ozempic and other GLP-1 agonists: Are they groundbreaking solutions, or shortcuts with hidden metabolic consequences? Timestamps: (0:00) Introduction (4:51) Can you be insulin resistant with normal glucose levels? (8:30) Can glucose monitors detect hidden insulin resistance? (10:01) What your skin reveals about insulin resistance (11:25) Why is insulin resistance behind so many chronic diseases? (15:46) Does obesity cause insulin resistance—or vice versa? (22:38) Insulin's surprising roles beyond blood sugar control (23:36) What's driving weight gain—insulin or calories? (30:30) Do saturated fats cause insulin resistance? (37:02) Why refined carbs amplify risks from saturated fat (40:04) Fructose vs. refined sugar—which spikes insulin more? (41:01) High-carb vs. keto—which diet controls hunger better? (45:27) Why low-carb diets might provide a metabolic advantage (47:36) Does exercise give you metabolic ‘wiggle room'? (52:00) Why strength training beats cardio for insulin sensitivity (54:03) Should you lower insulin before cutting calories? (57:12) Does meal frequency drive insulin resistance? (1:00:32) Is nighttime snacking giving you insomnia? (1:02:24) Can a sugary breakfast lead to overeating later? (1:07:19) Does late-night eating disrupt sleep more than blue light? (1:08:59) Can one bad night's sleep trigger insulin resistance? (1:12:23) Can air pollution cause weight gain? (1:16:15) Vaping vs. smoking—which is worse for metabolic health? (1:17:40) Can statins and antidepressants trigger weight gain? (1:20:22) How to reverse insulin resistance in 90 days (1:26:59) Does apple cider vinegar really lower blood sugar? (1:30:54) Ketone supplements—are the metabolic benefits real? (1:36:34) Why some ethnicities get diabetes without obesity (1:44:28) How oversized fat cells trigger metabolic chaos (1:49:28) Do seed oils silently promote insulin resistance? (1:52:44) Seed oils—always harmful or only when heated? (1:58:35) Fat, muscle, or liver—where does insulin resistance start? (2:04:21) Do fat cells shrink or disappear with weight loss? (2:07:05) Are shrunken fat cells still insulin resistant? (2:08:15) Can exercise and cold therapy specifically shrink visceral fat? (2:09:40) Injecting insulin for muscle—are the risks worth it? (2:12:45) Are drugs like Ozempic a shortcut or solution for obesity? (2:19:12) Are current GLP-1 agonist doses too high? (2:20:02) Microdosing GLP-1 drugs—a solution for carb cravings? (2:26:01) Do these medications cause muscle loss—or is it poor nutrition? (2:28:30) Do GLP-1 agonist benefits extend beyond weight loss? (2:30:41) Could these treatments actually promote longevity? (2:36:12) The dark side of GLP-1 drugs—can they trigger depression? (2:39:31) Insulin vs. glucose—what really drives accelerated aging? (2:44:34) How high glucose levels damage cells—from glycolysis to sorbitol (2:46:40) How insulin shuts down your body's stress defenses (2:51:15) Which biomarkers best predict biological aging? (2:55:05) One simple breakfast change to lower insulin (2:57:19) Does eating dinner early improve insulin sensitivity? Show notes, transcript, and summary are available by clicking here Watch this episode on YouTube

Found My Fitness - Rhonda Patrick Key Takeaways  To some degree, insulin resistance is a common root cause for most chronic diseases A low-carb diet may offer a metabolic advantage by reducing insulin levels, which enhances metabolic flexibility and improves energy regulationFat tissue has a much higher metabolic rate when insulin levels are lowSince there is much more metabolic uncoupling, the body's engine revs up to burn energy just to create heat   How to reverse a diabetes diagnosis in 90 days Control carbs – focus on whole fruits and vegetables, limiting sugary or starchy choices like bananas, pineapples, and mangoes Prioritize protein and do not fear fat – eat protein-rich foods regularly, and do not worry too much about naturally occurring fats Time meals and exercise – Eat more calories earlier in the day, avoid late-night eating, and take short walks after your biggest meals to reduce blood sugar spikesEating an evening snack spikes your blood sugar and ramps up the sympathetic nervous system, thus increasing body temperature and increasing the likelihood of insomnia and poor sleep; so do not eat within the 3-4 hours before bed Muscle is a great glucose consumer: The more muscle you have, the more metabolic wiggle room you have because muscle serves as a glucose sink Blood-sugar-lowering supplements that work:magnesium,alpha lipoic acid (ALA),berberine, andapple cider vinegar Eating too much linoleic acid (from seed oils) can lead to the production of a toxic substance (4H&E) that prevents your body from creating new small fat cells, and instead forces existing fat cells to just swell upConcerning GLP-1 dosing, caution is warranted; it is probably better to microdose these powerful drugs and think of them as short-term behavioral modification tools instead of lifelong prescriptions  The top biomarkers to measure to determine metabolic health and aging:(1) fasting insulin; want below 6 µIU/mL), (2) Triglyceride-to-HDL ratio; want ratio under 1.5, and (3) Uric acid; want lower levels generallyLower your insulin by starting with tomorrow's breakfast: Either fast through breakfast and drink coffee, tea, or yerba mateOr if you do want to eat, then choose low-glycemic-load vegetables and berries, and consume more protein and fat  Do whatever you can to keep your insulin in check for as long as possible throughout the day; the longer the insulin is low, the more you will improve your insulin sensitivity Read the full notes @ podcastnotes.org Get access to 130 episodes of my premium podcast, The Aliquot, as a FoundMyFitness Premium Member Insulin resistance silently shapes the trajectory of nearly every major chronic disease, yet it's often overlooked until blood sugar abnormalities become obvious. In this episode, Dr. Ben Bikman exposes the dietary culprits that drive metabolic dysfunction and highlights actionable, evidence-based tactics for improving metabolic health. Ben also addresses pressing questions about popular weight loss medications like Ozempic and other GLP-1 agonists: Are they groundbreaking solutions, or shortcuts with hidden metabolic consequences? Timestamps: (0:00) Introduction (4:51) Can you be insulin resistant with normal glucose levels? (8:30) Can glucose monitors detect hidden insulin resistance? (10:01) What your skin reveals about insulin resistance (11:25) Why is insulin resistance behind so many chronic diseases? (15:46) Does obesity cause insulin resistance—or vice versa? (22:38) Insulin's surprising roles beyond blood sugar control (23:36) What's driving weight gain—insulin or calories? (30:30) Do saturated fats cause insulin resistance? (37:02) Why refined carbs amplify risks from saturated fat (40:04) Fructose vs. refined sugar—which spikes insulin more? (41:01) High-carb vs. keto—which diet controls hunger better? (45:27) Why low-carb diets might provide a metabolic advantage (47:36) Does exercise give you metabolic ‘wiggle room'? (52:00) Why strength training beats cardio for insulin sensitivity (54:03) Should you lower insulin before cutting calories? (57:12) Does meal frequency drive insulin resistance? (1:00:32) Is nighttime snacking giving you insomnia? (1:02:24) Can a sugary breakfast lead to overeating later? (1:07:19) Does late-night eating disrupt sleep more than blue light? (1:08:59) Can one bad night's sleep trigger insulin resistance? (1:12:23) Can air pollution cause weight gain? (1:16:15) Vaping vs. smoking—which is worse for metabolic health? (1:17:40) Can statins and antidepressants trigger weight gain? (1:20:22) How to reverse insulin resistance in 90 days (1:26:59) Does apple cider vinegar really lower blood sugar? (1:30:54) Ketone supplements—are the metabolic benefits real? (1:36:34) Why some ethnicities get diabetes without obesity (1:44:28) How oversized fat cells trigger metabolic chaos (1:49:28) Do seed oils silently promote insulin resistance? (1:52:44) Seed oils—always harmful or only when heated? (1:58:35) Fat, muscle, or liver—where does insulin resistance start? (2:04:21) Do fat cells shrink or disappear with weight loss? (2:07:05) Are shrunken fat cells still insulin resistant? (2:08:15) Can exercise and cold therapy specifically shrink visceral fat? (2:09:40) Injecting insulin for muscle—are the risks worth it? (2:12:45) Are drugs like Ozempic a shortcut or solution for obesity? (2:19:12) Are current GLP-1 agonist doses too high? (2:20:02) Microdosing GLP-1 drugs—a solution for carb cravings? (2:26:01) Do these medications cause muscle loss—or is it poor nutrition? (2:28:30) Do GLP-1 agonist benefits extend beyond weight loss? (2:30:41) Could these treatments actually promote longevity? (2:36:12) The dark side of GLP-1 drugs—can they trigger depression? (2:39:31) Insulin vs. glucose—what really drives accelerated aging? (2:44:34) How high glucose levels damage cells—from glycolysis to sorbitol (2:46:40) How insulin shuts down your body's stress defenses (2:51:15) Which biomarkers best predict biological aging? (2:55:05) One simple breakfast change to lower insulin (2:57:19) Does eating dinner early improve insulin sensitivity? Show notes, transcript, and summary are available by clicking here Watch this episode on YouTube

What if We're Using GLP-1 Medications All Wrong?Drugs like Ozempic, Wegovy, and Mounjaro are transforming the landscape of medical weight loss, but could their side effects be a sign that we're not harnessing their full therapeutic potential?In this eye-opening conversation, Dr. Ben Bikman, metabolic health researcher and professor at BYU, joins Dr. Bret Scher to explore a powerful new framework: using GLP-1 medications at low doses and for short durations to help curb carbohydrate cravings, break addictive eating cycles, and support long-term metabolic health.Rather than prescribing high doses indefinitely, Dr. Bikman proposes a more targeted approach:Microdosing GLP-1s to enhance satiety and reduce cravings for processed carbsUsing the medication as a temporary metabolic tool to support transitions to lower-carb dietsReducing long-term risks such as muscle loss, mood changes, and diminishing effectivenessEmphasizing the importance of habit change, insulin regulation, and muscle preservationThis conversation reimagines GLP-1s not as a lifelong solution, but as a catalyst for sustainable, low-insulin lifestyles, aligned with ketogenic and metabolic therapies.

Get access to 130 episodes of my premium podcast, The Aliquot, as a FoundMyFitness Premium Member Insulin resistance silently shapes the trajectory of nearly every major chronic disease, yet it's often overlooked until blood sugar abnormalities become obvious. In this episode, Dr. Ben Bikman exposes the dietary culprits that drive metabolic dysfunction and highlights actionable, evidence-based tactics for improving metabolic health. Ben also addresses pressing questions about popular weight loss medications like Ozempic and other GLP-1 agonists: Are they groundbreaking solutions, or shortcuts with hidden metabolic consequences? Timestamps: (0:00) Introduction (4:51) Can you be insulin resistant with normal glucose levels? (8:30) Can glucose monitors detect hidden insulin resistance? (10:01) What your skin reveals about insulin resistance (11:25) Why is insulin resistance behind so many chronic diseases? (15:46) Does obesity cause insulin resistance—or vice versa? (22:38) Insulin's surprising roles beyond blood sugar control (23:36) What's driving weight gain—insulin or calories? (30:30) Do saturated fats cause insulin resistance? (37:02) Why refined carbs amplify risks from saturated fat (40:04) Fructose vs. refined sugar—which spikes insulin more? (41:01) High-carb vs. keto—which diet controls hunger better? (45:27) Why low-carb diets might provide a metabolic advantage (47:36) Does exercise give you metabolic ‘wiggle room'? (52:00) Why strength training beats cardio for insulin sensitivity (54:03) Should you lower insulin before cutting calories? (57:12) Does meal frequency drive insulin resistance? (1:00:32) Is nighttime snacking giving you insomnia? (1:02:24) Can a sugary breakfast lead to overeating later? (1:07:19) Does late-night eating disrupt sleep more than blue light? (1:08:59) Can one bad night's sleep trigger insulin resistance? (1:12:23) Can air pollution cause weight gain? (1:16:15) Vaping vs. smoking—which is worse for metabolic health? (1:17:40) Can statins and antidepressants trigger weight gain? (1:20:22) How to reverse insulin resistance in 90 days (1:26:59) Does apple cider vinegar really lower blood sugar? (1:30:54) Ketone supplements—are the metabolic benefits real? (1:36:34) Why some ethnicities get diabetes without obesity (1:44:28) How oversized fat cells trigger metabolic chaos (1:49:28) Do seed oils silently promote insulin resistance? (1:52:44) Seed oils—always harmful or only when heated? (1:58:35) Fat, muscle, or liver—where does insulin resistance start? (2:04:21) Do fat cells shrink or disappear with weight loss? (2:07:05) Are shrunken fat cells still insulin resistant? (2:08:15) Can exercise and cold therapy specifically shrink visceral fat? (2:09:40) Injecting insulin for muscle—are the risks worth it? (2:12:45) Are drugs like Ozempic a shortcut or solution for obesity? (2:19:12) Are current GLP-1 agonist doses too high? (2:20:02) Microdosing GLP-1 drugs—a solution for carb cravings? (2:26:01) Do these medications cause muscle loss—or is it poor nutrition? (2:28:30) Do GLP-1 agonist benefits extend beyond weight loss? (2:30:41) Could these treatments actually promote longevity? (2:36:12) The dark side of GLP-1 drugs—can they trigger depression? (2:39:31) Insulin vs. glucose—what really drives accelerated aging? (2:44:34) How high glucose levels damage cells—from glycolysis to sorbitol (2:46:40) How insulin shuts down your body's stress defenses (2:51:15) Which biomarkers best predict biological aging? (2:55:05) One simple breakfast change to lower insulin (2:57:19) Does eating dinner early improve insulin sensitivity? Show notes, transcript, and summary are available by clicking here Watch this episode on YouTube

Fat Loss & Metabolism with Dr. Ben Bikman Challenging the dogma surrounding heart disease. (1:32) Is there a connection between dementia and heart disease? (12:05) Strength training and Alzheimer's. (17:49) Learning something new helps put off dementia. (22:45) The connection between insulin resistance and your body's inability to fight off infection. (25:17) We put TOO much attention on total cholesterol. (27:55) Fat cells dynamics explained. (30:13) Why your metabolism is EXTREMELY complex. (44:14) Mitochondrial uncoupling. (48:51) Ketones and athletic performance. (55:39) The problem with DNP. (58:11) Why he is a HUGE advocate of creatine. (1:01:03) The brain loves ketones. (1:04:33) Keep your running shoes in the closet, GO STRENGTH TRAIN! (1:05:32) The metabolic origins of chronic disease. (1:08:10) How GLP-1s are being overused and the proper way to use them. (1:14:48) The resurgence of religion. (1:37:57) As a scientist, did he ever doubt his faith? (1:41:28) The most profound moment of his life. (1:45:51) Related Links/Products Mentioned Why We Get Sick: The Hidden Epidemic at the Root of Most Chronic Disease - and How to Fight It – Book by Dr. Benjamin Bikman How Not to Get Sick: A Cookbook and Guide to Prevent and Reverse Insulin Resistance, Lose Weight, and Fight Chronic Disease – Book by Dr. Benjamin Bikman Unlock sharper focus and support long-term brain health with Ketone-IQ—clean brain fuel for deep work, mental clarity, and sustained energy with no crash. Get 30% off your subscription, plus a free gift with your second shipment at https://ketone.com/MINDPUMP June Special: Shredded Summer Bundle or Bikini Bundle 50% off! ** Code JUNE50 at checkout ** Most heart attack patients' cholesterol levels did not indicate cardiac risk Study: Doubling Saturated Fat in the Diet Does Not Increase Saturated Fat in Blood Insulin signal transduction pathway Mind Pump #1922: Fatphobia & Other Lies That Are Keeping You Fat, Unhealthy & Sick Diabulimia: Why This Eating Disorder Is So Dangerous for People with Diabetes Harris-Benedict equation - Wikipedia Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases DNP (Dinitrophenol): Overview, Mechanism, and Risks Mind Pump #2497: The Amazing & Weird Side Effects of Creatine Muscle strength and fitness linked to reduction in cancer deaths Fighting Cancer By Putting Tumor Cells On A Diet - NPR Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined Attenuated GLP-1 secretion in obesity: cause or consequence? Mind Pump #2597: Before You Take Ozempic, Wegovy, or Mounjaro Listen to This! Liraglutide modulates lipid metabolism via ZBTB20-LPL pathway Mind Pump #872: Dr. Warren Farrell- The Boy Crisis Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest/People Mentioned Benjamin Bikman (@benbikmanphd) Instagram Website Zach Bitter (@zachbitter) Instagram  Thomas N. Seyfried (@thomasseyfriedbc) Instagram Warren Farrell, PhD (@drwarrenfarrell) X/Twitter  

Unlock the secrets to reversing insulin resistance - the hidden driver of many chronic diseases like heart disease, cancer, and Alzheimer's.In this eye-opening episode, Dr. Benjamin Bikman, biomedical scientist and author of Why We Get Sick, reveals surprising truths about carbs, fats, protein, stress, and lack of sleep that can help you reclaim your metabolic health and resilience. Don't miss these game-changing strategies from a leading expert in the field.You can find Ben at: Website | Instagram | Episode TranscriptIf you LOVED this episode, you'll also love the conversations we had with Dr. Gabrielle Lyon about maintaining and building muscle through nutrition and exercise.Check out our offerings & partners: Join My New Writing Project: Awake at the WheelVisit Our Sponsor Page For Great Resources & Discount Codes Hosted on Acast. See acast.com/privacy for more information.

In this Metabolic Classroom lecture, Dr. Bikman dives into the central metabolic role of lipoprotein lipase (LPL)—a largely unsung but crucial enzyme that governs whether fat is burned or stored and even where it accumulates in the body.LPL is anchored to capillary walls in tissues like fat, muscle, heart, and lactating mammary glands. It acts as a metabolic gatekeeper, hydrolyzing triglycerides from circulating lipoproteins (like chylomicrons and VLDL) into free fatty acids. Depending on the tissue, those fatty acids are either burned (e.g., in muscle) or stored (e.g., in fat cells). LPL activity is influenced by hormones, diet, age, exercise, and weight status, and it plays a role in both fat distribution and metabolic disease.LPL expression is highly tissue-specific and hormonally regulated. For instance, insulin increases LPL in fat tissue (promoting fat storage) and suppresses it in muscle (reducing fat burning), whereas testosterone suppresses LPL in subcutaneous fat, especially in the buttocks and hips—explaining fat patterning differences between sexes. In contrast, estrogen increases LPL in subcutaneous areas, which supports healthier fat distribution in women. Interestingly, low-carb diets and exercise reverse this pattern, increasing muscle LPL and decreasing fat LPL, thus shifting the body into a fat-burning mode.Ben also explains how weight loss impacts LPL expression. During weight loss, LPL activity in fat tissue tends to decline, but LPL gene expression can paradoxically increase, setting the stage for weight regain. He cites long-term studies showing that individuals with higher adipose LPL activity after dieting are more likely to regain fat. LPL in muscle tissue, however, increases after weight loss and exercise, supporting greater fatty acid oxidation. Thyroid hormone also influences LPL in both fat and muscle, revving up metabolism in hyperthyroid states and lowering LPL activity in hypothyroidism.Finally, Ben links LPL to real-world clinical questions, including its role in insulin resistance, statin effects, thyroid hormone therapy, and sex hormone treatments like TRT. He emphasizes that LPL doesn't just respond to metabolism—it helps define it, and that insulin is the dominant regulator of this enzyme.Show Notes/References:For complete show notes and references, we invite you to become an Insider subscriber. You'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A after the lecture with Ben, ad-free podcast episodes, show notes and references, online Office Hours access, Ben's Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews.

Dr. Ben Bikman opens this lecture with a comprehensive overview of fluoride's history in public health, highlighting its original role in preventing dental cavities. However, he shifts the focus to its lesser-known systemic effects, particularly on metabolic health.Ben emphasizes emerging evidence that chronic exposure to fluoride—from water, toothpaste, and other products—can disrupt fat cell function and insulin sensitivity, both key pillars of metabolic regulation.Dr. Bikman explains how fluoride interferes with fat cell development by inhibiting PPARγ, a key regulator of adipogenesis. While this may initially seem beneficial (fewer fat cells), it actually leads to hypertrophic fat cells that are more insulin resistant and pro-inflammatory. Though human data is limited, epidemiological studies suggest a link between high fluoride exposure and abdominal obesity.Fluoride's impact extends to insulin resistance and pancreatic function. Rodent studies show impaired glucose tolerance and reduced insulin production following fluoride exposure. Mechanistically, this is due to oxidative stress damaging mitochondria in beta cells, impairing both insulin release and glucose uptake. Human studies—though sparse—have shown similar trends in high-fluoride areas with improvements upon fluoride reduction.Ben also explores fluoride's effects on mitochondrial function, liver health, brain development, and fertility. Mitochondrial damage in fat and liver cells impairs energy production and fat metabolism, potentially leading to fatty liver disease. In the brain, fluoride may lower IQ and disrupt thyroid function—especially harmful during development. In fertility, fluoride is linked to lower sperm count and hormone disruption in animal models. Dr. Bikman concludes by recommending avoiding fluoride in drinking water while acknowledging its limited role in dental care.Show Notes/References:For complete show notes and references, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A after the lecture with Ben, ad-free podcast episodes, show notes and references, online Office Hours access, Ben's Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com Hosted on Acast. See acast.com/privacy for more information.

This week, Dr. Bikman dives deep into the metabolic role of cortisol, the body's primary glucocorticoid. He explains that while cortisol is essential for survival—mobilizing energy during fasting or stress—chronically elevated levels can wreak metabolic havoc.Cortisol is produced by the adrenal cortex under direction from the hypothalamic-pituitary-adrenal (HPA) axis. Its main role is to ensure energy availability, stimulating glycogen breakdown, muscle catabolism, and fat breakdown in specific depots. However, long-term cortisol elevation, such as in Cushing's disease, leads to fat redistribution, muscle loss, insulin resistance, and increased risk of type 2 diabetes.Cortisol's metabolic effects are driven by its action on glucocorticoid receptors inside cells, activating genes like PEPCK and glucose-6-phosphatase that stimulate gluconeogenesis and increase blood sugar. It also indirectly causes insulin resistance by increasing ceramide accumulation, which interferes with insulin signaling in cells like muscle and fat. This, combined with glucose overproduction and muscle loss (the major glucose sink), creates a perfect metabolic storm: high blood sugar, high insulin, and reduced glucose uptake.The hormone also affects fat storage patterns. Cortisol enhances fat accumulation in visceral (abdominal) fat while stimulating fat loss in subcutaneous regions like the limbs. It increases fat uptake by upregulating lipoprotein lipase and blocks fat breakdown by suppressing hormone-sensitive lipase, especially in the abdominal region. Yet cortisol alone isn't enough to cause fat gain—insulin is still required. Ben illustrates this by showing how individuals with untreated type 1 diabetes have high cortisol and high appetite but still lose fat without insulin.Lastly, cortisol influences the brain's hunger and reward systems, increasing carbohydrate cravings through neuropeptide Y and dopamine signaling. Chronic stress or medical conditions that elevate cortisol can drive overeating and central obesity. In short, while cortisol is necessary, its chronic elevation leads to insulin resistance, fat redistribution, and loss of metabolic control.Show Notes/References:For complete show notes and references, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A after the lecture with Ben, ad-free podcast episodes, show notes and references, Ben's Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com#Cortisol #InsulinResistance #ChronicStress #GlucoseControl #MetabolicHealth #CushingsDisease #HormonalBalance #FatStorage #Ceramides #DrBenBikman #VisceralFat #FatLoss #SubcutaneousFat #BloodSugar #AppetiteRegulation #Type2Diabetes #Mitochondria #HPAaxis #CortisolAndCravings #FatDistribution

In this lecture, Dr. Bikman presents a framework for understanding the two primary patterns of insulin resistance onset—what he terms “fast” and “slow” insulin resistance.“Fast” insulin resistance happens quickly and can often be reversed just as rapidly. It's typically triggered by three major factors: elevated insulin (from frequent carb consumption), stress hormones like cortisol and epinephrine, and inflammation (from infection, injury, or autoimmune activity). These triggers lead to the cellular accumulation of ceramides, which interfere with insulin signaling at the molecular level. The good news, he emphasizes, is that when these triggers are removed, the insulin resistance can often resolve quickly.“Slow” insulin resistance, on the other hand, develops gradually and is more difficult to reverse. It begins in the fat cell, where prolonged exposure to insulin and excess calories causes hypertrophy—the fat cells get larger. As they grow, they become insulin resistant as a form of self-preservation, but this leads to a damaging cascade: elevated free fatty acids, chronic low-grade inflammation, and disruption of glucose control. Dr. Bikman describes how hypertrophic fat cells become hypoxic, triggering inflammation and impairing surrounding tissues.Unlike the fast form, slow insulin resistance is rooted in long-term lifestyle habits and takes time to correct. The standard advice to “just cut calories” fails to address the core issue—chronically high insulin. Instead, Ben recommends that people first focus on lowering insulin through carbohydrate restriction, which naturally curbs hunger, boosts energy expenditure, and allows fat cells to shrink in a sustainable way.He concludes that understanding whether your insulin resistance is fast or slow in origin can help shape more effective interventions. With better insight into the mechanisms—from ceramides to fat cell hypertrophy—comes better, more targeted strategies to improve metabolic health.Show Notes/References:For complete show notes and references, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A after the lecture with Ben, ad-free podcast episodes, show notes and references, Ben's Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com Hosted on Acast. See acast.com/privacy for more information.

During this week's Metabolic Classroom lecture, Ben explores the metabolic power of cold therapy, explaining how brief, controlled exposure to cold can significantly enhance metabolic function.He starts with a deep dive into brown adipose tissue (BAT), which is rich in mitochondria and burns calories to generate heat. Cold exposure activates BAT through norepinephrine, leading to mitochondrial uncoupling and energy expenditure without producing ATP. Interestingly, even white fat can be transformed into metabolically active “beige” fat, increasing thermogenesis.Dr. Bikman then moves into how shivering muscle activity contributes to thermogenesis. Unlike BAT, muscle contraction generates heat while performing work. Shivering triggers glucose uptake, improves insulin sensitivity, and releases irisin, a hormone that stimulates thermogenic activity in fat tissue. He also discusses AMPK activation, which plays a key role in facilitating this glucose-burning process.The lecture then highlights a series of hormones influenced by cold, including FGF21 and adiponectin, which boost fat oxidation, enhance insulin sensitivity, and promote mitochondrial biogenesis. Ben reflects on the broader role of the autonomic nervous system, emphasizing how cold therapy improves both sympathetic and parasympathetic function, promoting nervous system flexibility and resilience.Dr. Bikman wraps up by comparing cold exposure methods—from face immersion and cold showers to cryotherapy and full-body ice baths. He strongly endorses full-body cold water immersion as the most effective strategy, especially when shivering occurs post-immersion. His personal recommendation is the Morozko Forge ice bath (he has no vested interest in this company), citing its sustained metabolic impact and practical benefit. He closes by urging viewers to consider cold therapy as a scientifically grounded tool to support overall metabolic health.Show Notes/References:For complete show notes and references, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you'll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A after the lecture with Ben, ad-free podcast episodes, show notes and references, Ben's Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com#ColdTherapy #IceBath #BrownFat #MetabolicHealth #InsulinResistance #Mitochondria #ShiveringThermogenesis #AMPK #Irisin #FGF21 #Adiponectin #FatLoss #GlucoseControl #HealthOptimization #AutonomicNervousSystem #BeigeFat #WeightLossTips #Hormones #Biohacking #BenBikman #drbenbikman

Stress is a significant factor contributing to insulin resistance and, consequently, to weight management challenges. Today's episode features Dr. Benjamin Bikman on the primary causes of insulin resistance that can lead to weight gain, and Jeff shares personal protocols he adopted to lose 60 pounds.This episode originally aired on January 9, 2024This podcast is supported by: Sunlighten:Visit Sunlighten.com/commune  and use code ‘Commune' to save up to $600 on your Sunlighten Sauna.Puori:Go to Puori.com/COMMUNE use promo code COMMUNE to save 20% on a one-time purchaseStemregen:Get 20% off your first order at stemregen.co/commune with the code COMMUNEPODQualia:Go to qualialife.com/commune to try Qualia Senolytic backed by a 100 day money back guarantee, and use promo code Commune to get 15% off!LMNT:Get a free sample pack with any purchase at DrinkLMNT.com/COMMUNE

Dr. Ben Bikman explores blood sugar, weight loss, and hormonal health, sharing his expertise on how blood sugar imbalances contribute to chronic diseases. He clarifies the weight loss process, focusing on glucose, ketones, and GLP-1 hormones, particularly for women in midlife. Ben demystifies the ketogenic diet and explains how ketones impact men and women differently while offering practical tips for optimizing metabolism naturally. This episode provides valuable tools for anyone looking to improve their health and manage midlife weight gain. To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit https://drmindypelz.com/ep278 Dr. Benjamin Bikman is a renowned metabolic scientist and professor of Cell Biology and Physiology at Brigham Young University. His research focuses on the role of insulin and its impact on metabolic health, particularly insulin resistance and its association with chronic diseases. In his book Why We Get Sick: The Hidden Epidemic at the Root of Most Chronic Disease—and How to Fight It, Dr. Bikman explores the underlying causes of metabolic dysfunction and offers insights into maintaining metabolic health. Dr. Bikman has discussed the metabolic challenges women face during perimenopause and menopause, emphasizing the role of hormonal changes, particularly the decline in estrogen, which can lead to increased insulin resistance and fat accumulation.  Check out our fasting membership at resetacademy.drmindypelz.com. Please note our medical disclaimer.

Welcome to the metabolism masterclass!Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn't work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it's not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity. What You'll Learn: • The #1 driver of insulin resistance—and why most doctors miss it • Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction • How fasting, cold therapy, and red light impact your metabolism • The truth about carbs, seed oils, and why some people can't gain fat • How to tell if insulin resistance is wrecking your energy & health Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Benjamin's new book How Not To Get Sick : https://a.co/d/aADlMWv • Benjamin's YouTube Page – https://www.youtube.com/@benbikman • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps: 00:00 Trailer 00:52 Introduction to Dr. Benjamin Bikman 02:20 The Battle Against Conventional Dietetics 04:12 Understanding Insulin Resistance 06:29 The Two Paths to Insulin Resistance 10:19 Fasting and Metabolic Health 14:11 Insulin and Cognitive Enhancement 18:16 Identifying Insulin Resistance 30:12 The Role of Insulin in Fat Storage 42:04 Understanding Glucose and Insulin Dynamics 42:26 The Role of Exercise in Glucose Regulation 42:54 AMPK and Muscle Contraction 45:21 Calories In, Calories Out Debate 46:15 The Myth of Calorie Counting 50:13 Ketosis and Metabolic Rate 51:14 Intermittent Fasting and Muscle Preservation 55:21 Insulin Resistance and Ketogenic Diets 01:02:04 Circadian Rhythm and Insulin Sensitivity 01:08:08 Environmental Toxins and Insulin Resistance 01:13:03 The Impact of Seed Oils on Insulin Resistance 01:19:22 Final Thoughts and Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jordan Peterson sits down with bestselling author and bioenergetics Ph.D., Dr. Benjamin Bikman. They discuss the epidemic of insulin resistance in America and its profound effects on health, the sugar addiction crisis, how dopamine hijacks your brain, how to navigate the American diet, and the potential to fix it invitationally from the top down over the next four years. Benjamin Bikman earned a Ph.D. in bioenergetics at East Carolina University with a focus on the adaptations to metabolic surgeries in obesity. He continued to explore metabolic disorders, with a particular focus on insulin resistance, as a postdoctoral fellow at the Duke-National University of Singapore. As a professor at Brigham Young University and the director of its Diabetes Research Lab, Dr. Bikman has continued to study insulin, including its role as a regulator of human metabolism, as well as insulin's relevance in chronic disease. In addition to his research and teaching, Dr. Bikman actively serves as a research mentor to undergraduate and graduate students. He and his students frequently present and publish their findings. This episode was filmed on January 27th, 2025.  | Links | For Dr. Benjamin Bikman: On X https://x.com/BenBikmanPhD?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor On Instagram https://www.instagram.com/benbikmanphd/?hl=en On YouTube https://www.youtube.com/@benbikman Read Dr. Bikman's most recent book, “How Not to Get Sick: A Cookbook and Guide to Prevent and Reverse Insulin Resistance, Lose Weight, and Fight Chronic Disease” https://a.co/d/iPrxgTE 

88% of adults have metabolic disease, but what's really making us sick? Dr Benjamin Bikman reveals the hidden dangers of insulin and how to take control of your health  Dr Benjamin Bikman is a metabolic scientist and Professor of Cell Biology and Physiology. He is the host of ‘The Metabolic Classroom' podcast and author of books such as, ‘Why We Get Sick: The Hidden Epidemic at the Root of Most Chronic Disease―and How to Fight It'.  In this conversation, Dr Benjamin and Steven discuss topics such as, the link between insulin and infertility, how to lose weight without counting calories, how ketosis can boost brain function, and the negative effects of Ozempic on bone density.  00:00 Intro 02:19 My Mission to Help with Chronic Diseases 05:05 What Is Insulin Resistance? 13:53 What Causes Insulin Resistance? 21:01 Can Insulin Resistance Become Chronic? 25:22 The Importance of Fat Cells Shrinking or Expanding 34:53 What's the Evolutionary Basis of Insulin Resistance? 42:17 The Role of Insulin During Pregnancy 43:39 What Is Gestational Diabetes? 45:05 Does It Impact the Future Baby? 45:59 Women's Cancer Is Increasing While Men's Remains the Same 50:33 Ads 51:29 Alzheimer's and Dementia Are on the Rise 01:05:34 Ethnicities and Their Different Fat Distributions 01:10:03 What to Do to Extend Our Lives 01:19:31 Cholesterol: The Molecule of Life 01:22:15 Smoking Causes Insulin Resistance 01:23:52 Does Smoking Make Us Fat? 01:29:04 Ads 01:31:04 Ketosis and Insulin Sensitivity 01:39:16 Ketone Shots 01:41:12 Steven's Keto Journey 01:47:40 How to Keep Your Muscles on a Keto Diet 01:55:25 Are There Downsides to the Ketogenic Diet? 01:57:17 Is Keto Bad for Your Gut Microbiome? 02:07:05 Are Sweeteners Okay in a Keto Diet? 02:11:04 Is Salt Bad for Us? 02:19:22 The Importance of Exercise to Maintain Healthy Insulin Levels 02:22:03 Calorie Restriction 02:23:51 Why Don't We Just Take Ozempic? 02:26:19 The Side Effects of Ozempic 02:34:56 Why Liposuction Doesn't Work Long-Term 02:39:34 Who Believed In You When No One Else Did? Follow Dr Benjamin:  Instagram - https://g2ul0.app.link/29ILyDZLJQb  Twitter - https://g2ul0.app.link/mT5RKy1LJQb  Website - https://g2ul0.app.link/uSaQIc3LJQb  You can purchase Dr Benjamin's book, ‘How Not to Get Sick: A Cookbook and Guide to Prevent and Reverse Insulin Resistance, Lose Weight, and Fight Chronic Disease', here: https://g2ul0.app.link/bcuFsHbMJQb   Watch the episodes on Youtube - https://g2ul0.app.link/DOACEpisodes  My new book! 'The 33 Laws Of Business & Life' is out now - https://g2ul0.app.link/DOACBook  You can purchase the The Diary Of A CEO Conversation Cards: Second Edition, here: https://g2ul0.app.link/f31dsUttKKb  Follow me: https://g2ul0.app.link/gnGqL4IsKKb Sponsors: Fiverr - https://fiverr.com/diary and use code DIARY for 10% off your first order PerfectTed - https://www.perfectted.com with code DIARY40 for 40% off WHOOP - JOIN.WHOOP.COM/CEO Learn more about your ad choices. Visit megaphone.fm/adchoices

EP. 190: What if the key to not dying early—or at least living vibrantly—boils down to one thing? Metabolic health. In this episode, I sit down with Dr. Ben Bikman, one of the world's leading experts on insulin resistance & metabolic health. Dr. Bikman is a professor at Brigham Young University and the author of Why We Get Sick, a groundbreaking book that exposes how modern lifestyles are fueling diabetes, obesity, and heart disease. We break down: Why insulin resistance is the root cause of so many chronic conditions The real impact of GLP-1s on metabolism and fat cells The latest cutting-edge research on muscle and GLP1 from Dr. Bikman's lab at BYU What you can do today to take back control of your metabolic health How Insulin Resistance Fuels Chronic Disease—and What to Do About It The Surprising Role of Fat Cells in Metabolism and Hormone Balance Why ‘Eat Less, Move More' Fails Most People—and What Works Instead GLP-1s and Satiety: The Science Behind Appetite and Metabolic Control Cutting-Edge Metabolic Health Research from BYU That Could Change Everything Simple, Science-Backed Strategies to Boost Testosterone Naturally If you care about your hormones, metabolism, and long-term vitality, this episode is a must-listen. Join my FREE 21-Day Strength & Resilience Challenge to get started: www.drtyna.com/strengthandresilience Sponsored By: Timeline Timeline is offering 10% off your order of Mitopure. Go to timeline.com/drtyna.  Puori Go to Puori.com/drtyna and use code DRTYNA to get 20% off Purity Woods Go to puritywoods.com/DRTYNA or enter DRTYNA at checkout for 27% off Sundays Get 40% off your first order of Sundays. Go to sundaysfordogs.com/DRTYNA and use code DRTYNA at checkout. BIOptimizers For an exclusive offer go to bioptimizers.com/drtyna and use promo code DRTYNA On This Episode We Cover:  00:00:00 - Introduction 00:01:57 - Teaching at BYU 00:03:32 - Dr. Ben's books 00:05:42 - Defining insulin resistance 00:10:14 - Insulin resistance and chronic disease 00:17:50 - Viruses and fat cells 00:19:56 - Fast vs. slow insulin resistance 00:26:21 - Overfilled fat cells 00:28:24 - Issues with the “Eat less & exercise more” approach 00:31:27 - Genes and metabolic health 00:32:12 - Satiety & GLP-1 response 00:37:25 - Appetite control vs. suppression 00:39:22 - GLP-1 dosing 00:42:33 - Hormones and metabolism 00:48:13 - Estrogen replacement therapy and testing 00:51:57 - AMPK, mTOR, and supplementation 00:57:57 - Metformin study 00:59:46 - Easiest ways to increase testosterone Further Listening: 10 Health Trends We Are Ditching in 2025 | Solo Kick Off 2025 with Strength, Resilience & Purpose | Quick & Dirty The Surprising Health Connections Between You and Your Dog | Quick & Dirty Check Out Dr. Ben: Instagram Website Books Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.