Podcasts about Letrozole

Send us a textIn this episode of Taco Bout Fertility Tuesday, Dr. Mark Amols breaks down one of the most commonly overlooked causes of infertility: elevated prolactin levels, also known as hyperprolactinemia.If you've ever been asked about nipple discharge at a fertility consult and thought, “What does that have to do with getting pregnant?”—this episode is for you.Dr. Amols dives into:What prolactin is and why your body produces itHow elevated prolactin shuts down ovulation by disrupting GnRH, FSH, and LHThe connection between dopamine and prolactin controlCauses of high prolactin—including prolactinomas, medications, thyroid issues, and even stress or exerciseDiagnostic steps: when to repeat the test, when to order an MRI, and how to rule out macroprolactinFirst-line treatments (cabergoline, bromocriptine) and what to expect during recoveryHow untreated hyperprolactinemia affects IUI, Clomid, Letrozole, and IVF outcomesLearn how to identify this hormone imbalance, when to treat it, and how correcting it can restore ovulation and dramatically improve your chances of pregnancy.Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.

  Join The Conception Connection  The Conception Connection    If you're trying to get pregnant, there's a good chance your doctor has mentioned Letrozole (Femara) as a first step. It's one of the most commonly prescribed fertility drugs — but is it really the best option? In this episode, I'm unpacking what every woman needs to know before taking Letrozole, especially if you're considering a more root-cause, holistic path to pregnancy. You'll learn: Why Letrozole is a first-line medication in many fertility clinics How it works to stimulate ovulation (and when it may not be helpful) The success rates, cost, and side effects you're not always told about What to consider if you're already ovulating naturally Why holistic approaches like mineral balancing, HTMA testing, and nervous system support often work better long-term Whether you're just starting your TTC journey or considering alternatives to fertility meds, this episode will help you make an informed, empowered decision.   Grab the FREE Unexplained Infertility Masterclass Masterclass   Grab the Free Checklist: Fertility Checklist and Guide   Let's connect on Instagram: @fruitfulfertilityco   Let's do HTMA together! The HTMA Bundle

      Guy Nakoa has survived two diagnoses of Stage IV breast cancer.  He initially felt a lump in his breast while showering in 2000.  Because it wasn't causing him and because he didn't think could not get a type of cancer associated with women, I went more than a decade before he chose to have the lump checked out.  In 2014, he sought medical attention, he was diagnosed and in 2016, he had the lump removed; but in 2020, the cancer returned.  He was hoping it could be removed with chemotherapy and radiation treatment, but over his initial objection, he agreed to a mastectomy of his left breast in 2024.  For the rest of his life, he will need to be on two medications, ibrance and letrozole.  Guy says from time to time he experiences fatigue but is very happy to be alive.   Guy Nakoa is from Wailuku on the island of Maui in Hawaii, but he has worked all over the world as a chef.  He was on a job in Alaska in 2000, when while taking a shower, he was shocked to feel a lump in his left breast.  Guy didn't tell anyone about it because it wasn't causing him any pain, and he felt too embarrassed to admit he may have a type of cancer that is generally associated with women.    He finally decided to have the lump examined in 2014.  His doctor didn't seem to think there was anything cancerous and told Guy not to worry about it.  Guy was misdiagnosed and he believes that, like he was, his doctor might have had difficulty connecting the lump with cancer because Guy is male.  Guy went to another doctor, and in 2016, he underwent a biopsy, which revealed he had breast cancer.    Guy Nakoa had the lump removed in 2016.  He underwent a chemotherapy regimen in 2017 and again in 2018.  He says he lost his sense of taste, his anxiety level went “through the roof” and he had a tough time getting to sleep.   The surgery was a success, but in 2020, the cancer returned.  Guy wanted to again treat it with chemotherapy and radiation, but his doctor urged him to get the breast removed.  Guy eventually relented and the mastectomy took place in 2024.   Guy says these days, he can do just about anything he could do before he first felt the lump, but fatigue sometimes sets in, in a way it didn't prior to his diagnosis.  By way of advice, he is quite adamant that, regardless of what seems irregular, if you notice something, anything abnormal about your health, to immediately seek medical attention.   Additional Resources:   Support Groups:   The Male Breast Cancer Global Alliance  https://www.mbcglobalalliance.org   Man Up To Cancer  https://www.manuptocancer.org   HIS Breast Cancer Awareness  https://www.hisbreastcancer.org      

Send us a textIn this episode of Taco Bout Fertility Tuesday, Dr. Mark Amols pulls back the curtain on the often-unspoken truth: fertility treatments don't always go as planned. From failed ovulation and sperm no-shows during IUI, to egg retrieval curveballs, fertilization failures, and embryo transfer nightmares in IVF—this episode covers the chaos that can catch patients off guard.But don't worry, this isn't about fear—it's about power through preparation. Dr. Amols shares real-world scenarios, explains the why behind the “what the heck just happened,” and helps you walk into treatment with eyes wide open and expectations aligned.Because hope isn't blind optimism—it's knowing the risks and choosing to try anyway.Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.

What if the pill you were given to help you ovulate wasn't actually helping—or even making things worse—and no one was checking? In today's episode of Cycle Wisdom, Dr. Monica Minjeur reveals the often-overlooked truth about ovulation stimulation with medications like Clomid and Letrozole. You'll hear Hope's story—a 29-year-old nurse frustrated by impersonal care and harsh side effects—and how a personalized, restorative approach helped her conceive naturally.Dr. Minjeur explains how conventional care often relies on guesswork and outdated protocols, while restorative reproductive medicine uses real-time hormone data, follicular ultrasound tracking, and individualized care plans to optimize ovulation and minimize risk. If you've ever felt lost in the fertility process or pressured to "just take a pill," this episode is for you.✨ Learn more or book your free discovery call at radiantclinic.com

On this episode of The Wholesome Fertility Podcast, I am joined by Dr. Nirali Jain (eggspert_md), a board-certified OB/GYN and reproductive endocrinologist at Reproductive Medical Associates (RMA). Dr. Jain shares her expert insights on fertility preservation for individuals undergoing cancer treatment, a crucial yet often overlooked aspect of reproductive care. We explore what options are available for fertility preservation, including egg and sperm freezing, and why it's so important to initiate these discussions before starting chemotherapy or radiation. Dr. Jain also explains the difference between Letrozole and Clomid, the impact of estrogen-sensitive cancers on IVF treatments, and innovative approaches like random-start cycles and DuoStim protocols. Whether you're facing a cancer diagnosis or simply thinking proactively about your reproductive future, this conversation is filled with knowledge and reassurance. Key Takeaways: Why it's essential to discuss fertility before starting cancer treatment. The role of Letrozole in estrogen-sensitive cancers and fertility preservation. Differences between Letrozole and Clomid, and why Letrozole is often preferred. How new protocols like DuoStim and random-start cycles are improving outcomes. Why fertility preservation is important even for those without a cancer diagnosis. Guest Bio: Dr. Nirali Jain (@eggspert_md) is a board-certified OB/GYN and fertility specialist at Reproductive Medicine Associates (RMA) in Basking Ridge, New Jersey. She earned both her undergraduate degree in neurobiology (with a minor in dance!) and her medical degree from Northwestern University, before completing her residency at Weill Cornell/NYP, where she served as co-Chief Resident, and her fellowship in reproductive endocrinology and infertility at NYU Langone. Deeply passionate about women's health and fertility preservation, Dr. Jain blends the latest research and cutting-edge treatments with compassionate, patient-centered care. Her interests include third-party reproduction and oncofertility, and she is especially passionate about supporting patients navigating fertility preservation through a cancer diagnosis. Outside of the clinic, Dr. Jain is a trained dancer, a dedicated global traveler, and an adventurer working toward hiking all seven continents with her husband. Her diverse experiences, from international medical rotations to personal connections with friends and family navigating infertility, have shaped her into a warm, resourceful, and determined advocate for her patients. Links and Resources: Visit RMA websiteFollow Dr. Nirali Jain on Instagram For more information about Michelle, visit www.michelleoravitz.com To learn more about ancient wisdom and fertility, you can get Michelle's book at: https://www.michelleoravitz.com/thewayoffertility The Wholesome Fertility facebook group is where you can find free resources and support: https://www.facebook.com/groups/2149554308396504/ Instagram: @thewholesomelotusfertility Facebook: https://www.facebook.com/thewholesomelotus/ Disclaimer: The information shared on this podcast is for educational and informational purposes only and is not intended as medical advice. Please consult with your healthcare provider before making any changes to your health or fertility care. --  Transcript:   # TWF-Jain-Nirali (Video) ​[00:00:00]  **Michelle Oravitz:** Welcome to the podcast Jain.  **Dr. Nirali Jain:** Thanks so much for having me **Michelle Oravitz:** Yeah, so. **Michelle Oravitz:** I'm very excited to talk about this topic, which, um, actually you don't really hear a lot of people talking about, which is how to preserve your fertility if you're going through a cancer diagnosis and if you have to go through treatments. 'cause obviously that can impact a lot on fertility. **Michelle Oravitz:** I have, um, seen actually like a colleague of mine go through. And she also preserved her fertility and, and now she has a baby boy. so it's really nice. **Michelle Oravitz:** to **riverside_nirali_jain_raw-video-cfr_michelle_oravitz's _0181:** so nice. **Michelle Oravitz:** So I'd love for you first to introduce yourself and kind Of give us a background on how you got into this work. **Dr. Nirali Jain:** Of course. Um, so I am Dr. Narly Jane. I am, um, an OB GYN by training, and then I did an additional, after completing four years of residency in OB GYN and getting board certified in that, I did an additional training in reproductive endocrinology and [00:01:00] infertility or otherwise known as REI. So now I'm a fertility specialist. **Dr. Nirali Jain:** Um, I trained at Northwestern in Chicago, so I went to undergrad and medical school there. And then, um, home has always been New Jersey for me, so I moved back out east to New Jersey. Um, I did all my training actually in New York City at Cornell for residency and NYU for fellowship. Um, and then moved to the suburbs. **Dr. Nirali Jain:** Um, and now I'm a fertility specialist in, in Basking Ridge at Reproductive Medical Associates.  **Michelle Oravitz:** Very impressive background. That's awesome.  **Dr. Nirali Jain:** Yeah. **Michelle Oravitz:** I'd love to hear just really. About what your process is. If a person has been diagnosed with cancer, like what is the process? What are some of the things that you address if they are trying to preserve fertility, and what are some of the concerns going  **Dr. Nirali Jain:** yeah, yeah. All great questions. So, you know, there's a lot of us, uh, the Reis. Are a very small, [00:02:00] there's a very small number of us. So in terms of specializing in fertility preservation, technically we all are certified to treat patients with cancer and kind of move them through fertility preservation before starting chemotherapy. **Michelle Oravitz:** Mm-hmm.  **Dr. Nirali Jain:** Um, luckily we've been working closely with oncologists in the past several years just to establish some type of streamlined system because having a diagnosis of cancer and hearing all that information. Especially when you're young is so hard. So I think that's, that's where my interest started in terms of being able to speak to and counsel cancer patients. **Dr. Nirali Jain:** I think it is a very specific niche that you really have to be comfortable with in our field. Um, I. So I'll kind of walk you through, you know, what it, what does it look like, right? Um, you go into your oncologist's office suspecting that you have this, this lump. I'll take breast cancer, for example. It could really be any kind of cancer. **Dr. Nirali Jain:** Um, but breast cancer in a reproductive age patient or someone that's in those years where you're starting [00:03:00] to think about building a family, planning a family, um, or if you have kids at home, that's usually the type of patient that we see come in with a breast cancer diagnosis. So. Kinda just taking that, for example, um, the minute that you're diagnosed, it's really your oncologist's responsibility to counsel you on what treatment options are going to be offered to you. **Dr. Nirali Jain:** And then based off of the treatment options, it's important to know how that affects your reproduction. So how does it affect your ovaries in the short term, in the long term, um, in any way possible. So. Once a patient is initially referred from their oncologist to myself or any other fertility specialist, they come into my office and we just have a 30 minute conversation really talking about family planning goals. **Dr. Nirali Jain:** Any kids that they've had in the past either naturally conceived or through um, IVF, and then we talk about where they're at in their relationship. Are they married, are they not? Are they with a partner, [00:04:00] a male partner, a female partner, whatever it might be. It's important to know the social standpoint, um, especially in this sensitive phase of life. **Dr. Nirali Jain:** So patient patients usually spend anywhere from 30 minutes to an hour. Um, just kind of talking through where they're at, how they're feeling, what their ultimate childbearing goals are. And then from there we do an ultrasound and that's when I'm really able to see, you know, the, the reproductive status. **Dr. Nirali Jain:** So what do the ovaries look like? What does the uterus look like? Is there something that I need to be concerned about from a baseline GYN standpoint? Um, and all of those conversations are happening in real time. So. I think one of the things is patients come in and they're like, I'm already so overwhelmed with all this information from my oncologist, and now my fertility specialist is throwing all this information at me. **Dr. Nirali Jain:** Luckily, the way I like to frame it is you come in and you just let go. Like you let us do the work because in the background we're the ones talking to your oncologist. We're the [00:05:00] ones giving that feedback and creating a timeline with your oncologist. Um, and really I think just getting in the door is the hardest part. **Dr. Nirali Jain:** So once patients are here to see us, we go through the whole workup. We do anything that we would do for a normal patient that came in for fertility preservation. And then based off of where they're at in their journey, we talk about what makes sense for them, whether that means freezing embryos, freezing eggs, they're very similar in terms of the, the few weeks leading up to the egg retrievals. **Dr. Nirali Jain:** So I have that whole conversation just at the initial visit. And then from there we talk about the timeline behind the scenes and make sure that it works with their lives before moving forward. **Michelle Oravitz:** So for people listening to this, why, and this might be an obvious question, but to some it might not be,  **Dr. Nirali Jain:** Mm-hmm. **Michelle Oravitz:** why would somebody want to preserve. eggs or sperm. 'cause I've had actually some couples  **Dr. Nirali Jain:** Yep. **Michelle Oravitz:** come to me where the husband preserved the sperm and they had to go through IVF just because he was going [00:06:00] through cancer treatments. So he had to preserve the sperm ahead of time.  **Dr. Nirali Jain:** Mm-hmm. **Michelle Oravitz:** people need to consider doing that before doing cancer treatments?  **Dr. Nirali Jain:** So there are certain cancer treatments that do affect the ovaries and the sperm health, and you know, for men and women, it affects your reproductive organs. In a similar way, um, depending on the type of chemotherapeutic agent, there are some that are more dangerous in terms of, um, being toxic to your ovaries or toxic to your sperm. **Dr. Nirali Jain:** And those are the instances where we are really thinking about what's the long-term impact because there's medications that oncologists do give patients, and our oncologists are amazing, the ones that we work with, Memorial Sloan Kettering from Reproductive Medical Associates through RMA, um, and. **Dr. Nirali Jain:** They're just so good at what they do and are so well-trained, so they know in the back of their mind, is this going to impact your ovaries or your sperm health or not? Um, and I [00:07:00] think that any chemotherapy, you know, your ovaries are these, these small organs that are constantly turning over follicles every month. **Dr. Nirali Jain:** So every month we're losing those eggs, and if they don't become. If an egg isn't ovulated, it doesn't become a baby, it's just gonna die off. So I counsel even patients that don't have cancer, I counsel them on fertility preservation as young as possible. You know, between the ages of 28 and 35, that's like the best time to preserve your fertility. **Dr. Nirali Jain:** So in cancer patients, there's an extra level added to that where even if they are a little bit younger, a little bit older. Your eggs are not gonna be the same quality. There's gonna be higher level of chromosomal errors, more DNA breakage, um, and, and bigger issues that lead to issues with conceiving naturally afterwards. **Dr. Nirali Jain:** So I think that it's important to consider how that chemotherapy is going to affect them or how surgery would affect them if it was, for example, a GYN cancer where [00:08:00] we're removing a whole ovary, you know, what, what do we have to do to preserve your fertility in that case? And those are important conversations to have. **Michelle Oravitz:** Yeah. for sure. I know that a lot of people are also concerned, you know, with going through the IVF process, you're taking in a lot of estrogen, a lot of hormones, and many cancers are actually estrogen sensitive. So I wanted to talk to you about that. 'cause I know that the data shows that it's. It's been fine, which some people might find surprising, but I wanted you to address that and just kind of **Dr. Nirali Jain:** Yeah. **Michelle Oravitz:** from your perspective.  **Dr. Nirali Jain:** That's so interesting that you asked that question because I actually, my whole I I graduated fellowship last year and my entire, like passion project in fellowship was looking at one of the drugs that we use to suppress the estrogen levels specifically in cancer patients. Um, and I had presented this at a few of our reproductive meetings. **Dr. Nirali Jain:** Um, A SRM is one of our annual meetings where all of the reiss get together. A lot of male fertility [00:09:00] specialists come and we kinda just talk about. Specific things and fertility preservation for cancer patients is, has been an ongoing topic of interest for all of us. Um, and it's important to know that there are different medications that we can offer. **Dr. Nirali Jain:** Letrozole is the one that I, um, have a particular love for and I, uh, you know, I use all the time for my patients, um, for different reasons, but it suppresses the exposure that your body has to estrogen. And there's mixed data, um, out there in terms of, you know, does Letrozole suppression actually impact, you know, does it help or. **Dr. Nirali Jain:** Or does it have no impact on your future risk of cancer after treatment? Um, and that honestly is still up for debate. But what we do know is that there's no increased risk of cancer recurrence in patients that have undergone fertility preservation with or without Letrozole. Um, Letrozole is one of those things that we can give, and the way it works is basically. **Dr. Nirali Jain:** It masks that [00:10:00] conversion. It, it doesn't allow for conversion from those androgens in the male hormones over to estrogen. Um, and so your body doesn't really see that estrogen exposure. It stays nice and low throughout your cycle, and it does help with actually ovarian maturation and getting mature eggs harvested and, um, helps a little bit with, with quality too. **Dr. Nirali Jain:** So I think that it's really nice in terms of having that available to us, but know that. It's not, it's not essential that you have it, really, the data showing plus minus. Um, but there are certain things that we can do to protect the ovaries, protect your exposure to estrogen. Um, and so that shouldn't be top of mind of concern when we're going through fertility preservation, even with an estrogen sensitive cancer. **Michelle Oravitz:** Actually, so, uh, on a different topic, kind of going back to that, so Letrozole versus Clomid, I, it's like a, the questions I personally feel just based on what I've heard and like my own research that Letrozole would be kind of like the more. [00:11:00] Um, the, it's, it's a little better, but I know that it really depends on the person as well.  **Dr. Nirali Jain:** Yeah, **Michelle Oravitz:** they might do better with Clom, but I'd love to hear your perspective and kind of pick your brain on this.  **Dr. Nirali Jain:** totally. You're choosing all the, all the right questions because these are all of my, my specific interests and niches. So  **Michelle Oravitz:** Oh,  **Dr. Nirali Jain:** Letrozole is basically, you know, we use Letrozole and Clomid in. Patients that don't have cancer and patients that come in for an intrauterine insemination, that's kind of the most common scenario where we're thinking about, you know, which medication is better? **Dr. Nirali Jain:** Letrozole or Clomid and Clomid used to be the, the most common medication that we use, we dose patients, you know, have 50 milligrams of Clomid, give them five days of the medication. It's an oral pill. Feels really easy and. The way it works is really, it recruits more than one follicle, so it really helps with the release of, um, more than one follicle growing more than one follicle in the ovary. **Dr. Nirali Jain:** Um, but it has a little bit [00:12:00] higher of a risk of twins because that's exactly what it's good at. Um, Clomid, not so much in the cancer. In the cancer front, it's not really used there because it's considered, from a scientific perspective, it's considered like a selective estrogen receptor modulator. So it doesn't necessarily suppress your estrogen levels in the same way that Letrozole does versus. **Dr. Nirali Jain:** Letrozole is an aromatase inhibitor, so it really blocks the chemical conversion of one drug or one hormone to the other hormone. Um, the reason we love Letrozole so much, and I don't mean to like gush over Letrozole, but um, it's a mono follicular agent, so it works really well at recruiting one follicle  **Michelle Oravitz:** Mm-hmm.  **Dr. Nirali Jain:** you know, every OB-GYN's nightmare in a way is having multiples when you didn't intend on having multiples at all. **Michelle Oravitz:** so  **Dr. Nirali Jain:** Um. **Michelle Oravitz:** were saying that, um, there's more of a chance of twins, it's Clomid, not letrozole.  **Dr. Nirali Jain:** Yes, there's a higher chance with Clomid versus Letrozole. And I mean, don't get me wrong, there's a chance of twins with [00:13:00] any type of assisted reproductive technology. Even when we're doing single embryo transfers, there's a chance that it's gonna split. So, um, the chance is always there just like it is in the natural world. **Dr. Nirali Jain:** But we know for a fact that. CLO is really good at recruiting many follicles. It's good for certain patients that don't respond well to Letrozole. Um, but Letrozole is kind of our, our go-to drug these days just because of all the benefits that we've seen.  **Michelle Oravitz:** Awesome.  **Dr. Nirali Jain:** Yeah, **Michelle Oravitz:** These are all fun things to ask because I, I love talking to our eis 'cause there's so much information that I'm always  **Dr. Nirali Jain:** totally. **Michelle Oravitz:** learn a lot from my patients in my own research, but it's really cool. Picking your guys' brains. So another question I have, and I have actually talked to Dr. Andrea Elli, he's been on,  **Dr. Nirali Jain:** Mm-hmm. **Michelle Oravitz:** and he does a lot of endometriosis and, and immune related work as well,  **Dr. Nirali Jain:** Yeah. **Michelle Oravitz:** so. I'd love to know just from your perspective. One thing that I do know from, based on what I've heard is that the, [00:14:00] guess like you were just saying, that breast cancer or estrogen sensitive breast cancer doesn't seem to be affected by IVF cycles, however, and endometriosis lesions do get affected.  **Dr. Nirali Jain:** Yeah. **Dr. Nirali Jain:** that's a great question. So, you know, every, there are so many complex G mind diagnoses that the, that our patients come in with. Um, and endometriosis is a big one because there is clear data that endometriosis is linked to infertility. So we think about, you know, when a patient comes in with endometriosis, we really do think about the different treatment options and what are the short-term and long-term impacts of the hormones that we're giving 'em. **Dr. Nirali Jain:** Um, these days, again, kind of going back to Letrozole, we, letrozole is something that I give all of my endometriosis patients because it helps suppress their estrogen because we know.  **Michelle Oravitz:** interesting.  **Dr. Nirali Jain:** is very responsive to estrogen and leads to this dysfunctional regulation of all the endometrial tissue that can really flare in a, [00:15:00] in a cycle, or shortly after a cycle. **Dr. Nirali Jain:** I. So we really, for endometriosis patients, the, the best treatment is being on birth control because we don't see that hormonal fluctuation. The up and down of the estrogen and the progesterone, that's what leads to those flares. Um, so I really, I watch patients closely after their cycles too, because you definitely can have an endometriosis flare and we say the best treatment for endometriosis is pregnancy, right? **Dr. Nirali Jain:** That's when you're suppressed, that's when you're at your lowest. Um, and patients, my endo patients feel so good in pregnancy because they have. Hormones that are nice in that baseline, they're not getting periods of course. Um, and that's truly, truly the best treatment.  **Michelle Oravitz:** That's interesting.  **Dr. Nirali Jain:** But it is important to consider when you're going through infertility treatments. **Dr. Nirali Jain:** How does my endometriosis affect the short and long-term effects of the fertility medications? And really not to, not to say that they're bad in any way. I think a lot of endometriosis patients go through IVF and have success and do really, really well, and that's kind of the push that they need. [00:16:00] Um, but it's important to be mindful of the bigger picture here. **Dr. Nirali Jain:** It's not just, you're not just a number of. A patient with endo coming in, getting the same protocol. It's really individualized to the extent of your lesions, what symptoms you're having, what grade of endometriosis, where your lesions are. So we're the RAs are thinking about everything before we actually start your protocol. **Michelle Oravitz:** It's crazy how in depth it is, and it's, it, there's just so, it's so multifaceted,  **Dr. Nirali Jain:** Yeah,  **Michelle Oravitz:** when it's females  **Dr. Nirali Jain:** totally. **Michelle Oravitz:** are a little, I mean, they can, you know, there, there's definitely a number of things, but it's not as complicated and interconnected  **Dr. Nirali Jain:** Exactly. Exactly. That's so true. **Michelle Oravitz:** And so one question I actually have, this is kind of really off topic, but something that I was curious about. **Michelle Oravitz:** 'cause I heard about a while  **Dr. Nirali Jain:** Yeah. **Michelle Oravitz:** a, a type of cancer treatment that was used. I'm not sure exactly what it was, but for some reason it actually caused follicles to grow, [00:17:00] or to multiply. And they were **Dr. Nirali Jain:** Interesting. **Michelle Oravitz:** this definitely. Puts, um, the whole idea of like a woman being born with all the follicles she'll ever have on its head, I thought that was really Interesting. **Michelle Oravitz:** Now I learned a little bit about it. I don't think it really went further than that,  **Dr. Nirali Jain:** Mm-hmm. **Michelle Oravitz:** one of those things that they're like, Hmm, this is interesting. I don't know, it was kind of a random side effect of this chemo drug. I dunno if it was a chemo drug or a cancer drug.  **Dr. Nirali Jain:** Yeah.  **Michelle Oravitz:** ever heard of that. **Michelle Oravitz:** So I was just **Dr. Nirali Jain:** I haven't, I mean, that's interesting. I feel like I'd have to look into that because that would be definitely a point of interest for a lot of Reis. But it kind of does go back to the point of, you know, women are really born with all the eggs we're ever gonna have. So it's about a million, and then it just goes down from there. **Dr. Nirali Jain:** And the, by the time you start having periods, I like to kind of show my patients a chart, but you have a couple hundred thousand eggs and you ovulate one egg a month. That's, you know. Able to [00:18:00] progress into a fertilized egg and then into a, an embryo into a baby, um, if that's your goal. But otherwise, patients that are having periods and not trying to actually get pregnant, we're losing hundreds of eggs a month. **Dr. Nirali Jain:** So.  **Michelle Oravitz:** Mm.  **Dr. Nirali Jain:** It's important to kind of think about that decline, and it's important to know that that rate can be faster in patients with cancer, patients with low ovarian reserve. And sometimes when you have the two compounded, that's when a fertility specialist is definitely, you know, in the queue to, to have a discussion with you in terms of what that means and how you can reach your family building goals despite being faced with that, with that challenge. **Michelle Oravitz:** Yeah. **Michelle Oravitz:** I mean, 'cause we know oxidative stress is one of the things that can cause, uh,  **Dr. Nirali Jain:** Yeah, **Michelle Oravitz:** quality eggs, but it's also can cause cancer. **Dr. Nirali Jain:** Yeah, **Michelle Oravitz:** um, similar, you know, like things that really deplete the body could definitely impact. Um, and then what are your thoughts? I know I'm asking you all kinds of random questions, **Dr. Nirali Jain:** I love it. **Michelle Oravitz:** are your thoughts about doing low simulation in certain [00:19:00] circumstances versus high stem? **Michelle Oravitz:** Sometimes people don't respond as well to higher stems.  **Dr. Nirali Jain:** Yeah, that's a great point. I think that it kind of all goes back to creating an individualized protocol. If. A patient's going to a practice and basically just getting a protocol saying, this is our standard. We start with our standard of, you know, I, I think about the standard, which is 300 of the FSH or that pen that you dial up, and then 150 units of that powder vial. **Dr. Nirali Jain:** And we have patients mixing powders all the time, and that's kind of our blanket protocol that we give patients. But that's not really what's happening behind the scenes. And if you're given a protocol that's, and being told, you know, this is kind of what we give to everyone, it's probably not the right fit for you. **Michelle Oravitz:** Yeah, I  **Dr. Nirali Jain:** Um, there are certain patients that respond to a much lower dose and do really, really well, and then some patients that need a much higher dose. Um, and I think it's, that's kind of like the fun part of being an REI of being able to individualize the [00:20:00] protocol to the patient. Um, and I know for a fact there are so many, luckily, you know, we have so many leaders in REI that have been. **Dr. Nirali Jain:** Have dedicated their entire careers to researching these different protocols and how they can help different patients. Um, patients with lower a MH, you know, might benefit from a duo stim protocol, for example. That's kind of the first one that comes to mind, but a protocol where we're using those follicles from the second half of a cycle. **Dr. Nirali Jain:** I would've never thought that those were the follicles that  **Michelle Oravitz:** Oh,  **Dr. Nirali Jain:** would be better than the first half of the cycle,  **Michelle Oravitz:** Wait,  **Dr. Nirali Jain:** but, **Michelle Oravitz:** that. Explain that. Um, because I think that that's kind of a unique  **Dr. Nirali Jain:** mm-hmm.  **Michelle Oravitz:** that I haven't heard of.  **Dr. Nirali Jain:** Yeah, so there's this new day. It's still kind of developing, but um, kind of going back to, you know, what's an individualized protocol? Duo STEM is one of the newer protocols that we've started using. I, I've used it once or twice in patients. Um, but it goes back to the research that shows that you might actually have two different periods of time in a menstrual cycle where you could potentially recruit [00:21:00] follicles. **Dr. Nirali Jain:** You could have a follicular phase where there's a certain cohort of follicles recruited, and then you have a follicle that forms creates a corpus glut.  **Michelle Oravitz:** um, protocols  **Dr. Nirali Jain:** Yep. And then you basically go through the follicular protocol and then a few days after a retrieval, instead of waiting for a new follicular cohort or follicular recruitment from the first half of your menstrual cycle, you actually use the luteal phase and you recruit those follicles that would've actually died off or have been prematurely recruited in a prior cycle. **Dr. Nirali Jain:** So **Michelle Oravitz:** that's So  **Dr. Nirali Jain:** yeah, **Michelle Oravitz:** you just do a similar, I guess, um, medicine,  **Dr. Nirali Jain:** go right back into it.  **Michelle Oravitz:** do the same exact thing, but right after ovulation.  **Dr. Nirali Jain:** Yeah.  **Michelle Oravitz:** Fascinating. That's really interesting.  **Dr. Nirali Jain:** Yeah,  **Michelle Oravitz:** has been your experience with that?  **Dr. Nirali Jain:** I think it's, honestly, it's mixed. Um, so far, you know, our data from fertility and sterility and A SRM, it, it shows support for these DUO STEM [00:22:00] protocols, saying that if patients don't have that great quality of eggs or if they have a very low number, maybe they'd benefit from starting the meds earlier and recruiting follicles. **Dr. Nirali Jain:** A little bit earlier. Um, so we've seen positive results so far. A lot of work to be done in terms of really understanding it. Um, and of course, as a new attending, I have a lot more experience to kind of build on. Um, but I, I have seen success from it. **Michelle Oravitz:** That's fascinating. Are there any other new technologies, like new add-ons, um, that you've seen, that you've found to be really cool or interesting?  **Dr. Nirali Jain:** I think the biggest thing, actually, kind of going back to our whole topic for today is fertility preservation cancer patients. One of the biggest things that I've learned recently is that we used to start fertility, um, patients. You know, only in the beginning of the cycle days, two or three is technically like when most. **Dr. Nirali Jain:** Most clinics, um, start patients, but for our cancer patients, sometimes you don't have that time. You don't wanna wait a full month to [00:23:00] restart, um, your, you know, your menstrual cycle and then do the fertility preservation and then delay chemotherapy a full month. So we started doing what we call random starts. **Dr. Nirali Jain:** So you basically start a patient whenever they come in. You know, it could be the day after your consultation, the day of your consultation. I've kind of seen all of the above. Um, and we've seen really good success with random starts, per se. Um, and we've been doing a lot more of that, where it's not as dependent on where you're at in your cycle. **Michelle Oravitz:** Mm-hmm.  **Dr. Nirali Jain:** Um, obviously there's a difference in outcomes. You might not be a great candidate for it, so definitely it's worth talking to your doctor about it. But it kind of gives relief to our cancer patients where if you have a new cancer diagnosis and you're like, oh, I just finished my period, like, I can't even start a cycle until next month. **Dr. Nirali Jain:** That's not always true. Um, so it's always worth it to go into see a fertility specialist and just get, you know, get the data that you need right away, and then you can make a decision later on. **Michelle Oravitz:** For sure. Um, Yeah. **Michelle Oravitz:** and I wanted to kind of cover a lot of different topics 'cause I know that [00:24:00] some people are gonna wanna hear what you have to say that don't necessarily, or, uh, have cancer. But it is important. I, I think that, you know, if you get to thirties and you haven't gotten married or you don't have a partner, I think it's really important to preserve your fertility in general.  **Dr. Nirali Jain:** Yeah, **Michelle Oravitz:** important thing. And then if you were going through a cancer diagnosis and you decided to preserve your fertility, um, guess more for women because they're eventually going to be thinking about transfers after they go through treatment. So what are some of the things that they would need to consider as far as that goes? **Michelle Oravitz:** Like after the  **Dr. Nirali Jain:** yeah, **Michelle Oravitz:** then they go through the cancer treatments. Um, and then what, how long should they  **Dr. Nirali Jain:** yeah. Like what does it look like? So I've had patients that come back, you know, in my fellowship training I did a, a couple research projects on patients that came back to pursue an embryo transfer, um, after chemotherapy agent. And basically compared them to how they did, um, [00:25:00] compared to patients that didn't have cancer and just froze their embryos or froze their eggs and then came back to pursue a transfer and. **Dr. Nirali Jain:** I think the, the most reassuring thing from the preliminary data that we have is saying that there's no difference in pregnancy rates and no difference in life birth,  **Michelle Oravitz:** Awesome.  **Dr. Nirali Jain:** of whether they had chemotherapy or not. After freezing those eggs and going through fertility preservation.  **Michelle Oravitz:** Amazing.  **Dr. Nirali Jain:** Um, in terms of where your body needs to be, I think the oncologist, we, we wait for their green light. **Dr. Nirali Jain:** We wait for their signal to say, you know, she's safe to carry a pregnancy.  **Michelle Oravitz:** Mm-hmm.  **Dr. Nirali Jain:** And then once we do that, we basically treat you like any other patient. So if you're coming in for a cycle, if you're having periods, then it's reasonable to try a natural cycle protocol, wait for your body to naturally ovulate an egg. **Dr. Nirali Jain:** And instead of obviously hoping that egg will fertilize, we, um, use a corpus luteum. We use the progesterone from the corpus luteum to really support this embryo being implanted into the uterus. Um. Yeah. [00:26:00] And then there's also another side. I mean, some patients don't get their periods back and they always ask like, what if I never get my period back? **Dr. Nirali Jain:** What if I'm just like in menopause because of the chemotherapy agents? And for that, we can start you on a synthetic protocol or basically an estrogen dependent protocol where you take an estrogen pill for a certain number of days. We monitor your lining, then we start progesterone, um, to support your hormones from that perspective instead of relying on your ovaries to release the progesterone that they need, um, and then doing the embryo transfer a few, few days after progesterone starts. **Dr. Nirali Jain:** So there's definitely different protocols depending on where your menstrual health is at after the chemotherapy or after the cancer treatment. Um, but it's important to kind of just know that. That there's options. It doesn't mean that it's the end of the road if you all of a sudden stop getting your period. **Michelle Oravitz:** Yeah, for sure. I mean, 'cause you, technically speaking, you can really control a lot of that. More so for transfers  **Dr. Nirali Jain:** Yep. **Michelle Oravitz:** Retrievals really is kind of like what [00:27:00] eggs you have, what the quality is. But people can be in complete menopause and you guys can still control their cycles for transfer, which is kind of. A huge difference  **Dr. Nirali Jain:** Yeah,  **Michelle Oravitz:** in the  **Dr. Nirali Jain:** exactly. That's exactly right. Yeah. **Michelle Oravitz:** interesting. Any other, um, new, new things that you're, you guys are excited about? I always like to hear about like the new and upcoming things  **Dr. Nirali Jain:** Of course.  **Michelle Oravitz:** actually before, which I thought was fascinating. Yeah.  **Dr. Nirali Jain:** I feel like there's always like updates and, and new data and things like that coming out, but just know, I think it's important for patients to know, like we're constantly, we're, the reason I chose to even pursue this field was because it's new. Right. There's something that we are discovering every day, every year, and that's what makes our, our conferences so important to attend, um, to really just stay up to date. **Dr. Nirali Jain:** Um, but we are, uh, constantly updating our embryology standards, the way we thaw our eggs, and the success rate associated with a thaw and [00:28:00] how we treat our embryos and the media that we use, right? Like, so we're really thinking about the basic science perspective every single day, and that's what makes this field so unique. **Michelle Oravitz:** It is really awesome. And so do you guys specialize specifically on, um. Egg freezing and, and I mean specific fertility preservation in patients that do that have cancer that are going through treatments, do you guys specialize specifically in that? I mean, I know you do range  **Dr. Nirali Jain:** Yeah. Yeah, because it's such a small community, we all have our own niches and we all kind of have our own interests and  **Michelle Oravitz:** Yeah.  **Dr. Nirali Jain:** no like specific training. There are a couple courses that you take that I took in in training as well, just to kind of understand what it sounds like to, I. Council of fertility preservation, patient with and without cancer. **Dr. Nirali Jain:** Um, and then, you know, you kind of just learn by experience and you form a niche for something that you're passionate about. 'cause that's what makes you, you know, really thorough in, in your treatment. [00:29:00] So that's one of my interests. Um, and, but I would say,  **Michelle Oravitz:** training for that. It's just like  **Dr. Nirali Jain:** yeah, **Michelle Oravitz:** just know how to treat that in  **Dr. Nirali Jain:** exactly.  **Michelle Oravitz:** especially if you're interested in doing that.  **Dr. Nirali Jain:** Exactly. That's exactly right. It's kind of, it just comes with the experience comes with your mentors and who you're surrounded by, and everyone kind of helps each other get to that point. But there are several specialists in our practice at RMA that specialize specifically in fertility preservation in cancer patients. **Dr. Nirali Jain:** So we have a close communication with our oncologist and they know who to refer to within the practice because everyone has their own little interests.  **Michelle Oravitz:** Amazing.  **Dr. Nirali Jain:** Yeah. **Michelle Oravitz:** Um, definitely. I, like I said, I really enjoy picking your brain because it's a lot of fun for me. I, I do  **Dr. Nirali Jain:** Totally.  **Michelle Oravitz:** acupuncture, so  **Dr. Nirali Jain:** Yeah, **Michelle Oravitz:** and I, I think that it's just so crazy that our fields don't work together. I mean, we kind of do, but I think, I just feel like it would be so great  **Dr. Nirali Jain:** exactly.[00:30:00]  **Michelle Oravitz:** the expertise because you guys have immense. Benefits like in, in, uh, technology and incredible innovations and, and then the natural aspect of really understanding the, the body. And I, I just think that it would work so amazing together if it was more of like a thing. 'cause it, I know in China they actually combine the two  **Dr. Nirali Jain:** Yeah.  **Michelle Oravitz:** eastern.  **Dr. Nirali Jain:** Yeah, I mean I think that that's so important and there is data that shows, you know, there's actually a recent study that came out just a few weeks ago on the benefits of acupuncture for fertility patients. And we know that, I mean, I recommend it to all of my patients, specifically the day of the embryo transfer. **Dr. Nirali Jain:** We, luckily, we offer it on site at RMA and we have acupuncturists that come in and, and do a session before and after the embryo transfer, and I think. A lot of that is targeted towards stress relief. But I also think that holistically it's important to feel at your best when we're doing something that's so crucial to your, to your health. **Dr. Nirali Jain:** So to really focus on the diet, focus on stress relief, [00:31:00] focus on meditation, yoga, whatever it takes to get to your best wellbeing when you're going through fertility treatments, um, is so important. So I appreciate  **Michelle Oravitz:** Mm-hmm.  **Dr. Nirali Jain:** like you that really specialize in the other side of. Of this, because I do consider it still part of the holistic medicine that we need to really maximize success for our patients. **Michelle Oravitz:** Awesome. Well,  **Dr. Nirali Jain:** Yeah, **Michelle Oravitz:** Jane, this is such a pleasure Of talking to you. You've given us some, so much great information and we've definitely dived into a, do a topic that I don't typically, I haven't yet spoken about. But, um, that being said, it's such an important topic to talk about. And thank you so much for coming on today. **Michelle Oravitz:** Oh,  **Dr. Nirali Jain:** course. **Michelle Oravitz:** I get off, how can people find you?  **Dr. Nirali Jain:** That's a great question. So I have, um, a social media page. I, it's called Expert nc. So like EGG,  **Michelle Oravitz:** I  **Dr. Nirali Jain:** um, expert nc. Try, tried to make it a little bit humorous. Um, but I'm all over social [00:32:00] media and would love to hear from anyone that is listening. I, you know, every, every day I get different, um, dms and I'm happy to respond. **Dr. Nirali Jain:** I love hearing about everyone else's. Stories and things like that. Um, so that is kind of my main, main social media platform. Um, and then through like RMA and Reproductive Medical Associates, we also have a YouTube channel. We have an Instagram page, um, of our office available, um, as well that is public. **Dr. Nirali Jain:** So you can find us pretty easily if you just kind of hit Google. But um, yeah, I'm kind of developing my social media platform as the expert and I hope it grows.  **Michelle Oravitz:** Love it. Great.  **Dr. Nirali Jain:** Yeah.  **Michelle Oravitz:** was such a pleasure talking to you. Thank you. so much **Dr. Nirali Jain:** Thank you. **Michelle Oravitz:** today.  **Dr. Nirali Jain:** Of course. Thank you so much for having me.  [00:33:00]   

Take a sneak peek at this month's Fertility & Sterility! Articles discussed this month are:   01:47 Puberty progression in girls with Turner syndrome after ovarian tissue cryopreservation 14:55 Optimal Restoration of Spermatogenesis following Testosterone Therapy using hCG and FSH 27:58 Human embryos with segmental aneuploidies display delayed early development: a multi-centre morphokinetic analysis 39:56 Neurodevelopmental or behavioural disorders in children conceived after assisted reproductive technologies: A nationwide cohort study 45:23 Efficacy and safety of estetrol (E4) 15 mg/drospirenone (DRSP) 3 mg combination in a cyclic regimen for the treatment of primary and secondary dysmenorrhea: A multicenter, placebo-controlled, double-blind, randomized study 51:13 Ovulation trigger versus spontaneous LH surge on live birth rate following frozen embryo transfer in a natural cycle: a randomized controlled trial 60:29 A Cost Analysis of Clomiphene Citrate, Letrozole and Gonadotropin with Intrauterine Insemination using Outcome Data from the AMIGOS Trial   View Fertility and Sterility at https://www.fertstert.org/

Welcome to another heartfelt episode of the Fertility in Focus Podcast with your host, Dr. Christina Burns.In this episode, Dr. Christina is joined by Michelle Villatoro, a hospitality strategist and founder of Just Think Hospitality, who courageously shares her deeply personal and emotional fertility journey. Together, they explore the emotional highs and lows of trying to conceive, how she struggled with a very low ovarian reserve, multiple IVFs, an ectopic pregnancy, and more. They talk through the suggestions on how to speak to someone going through a fertility challenge and the effects of the medications and process on the mental health of the patient.  As always Dr. Christina is solutions focused and so covers ways to find peace and power in the process. The conversation explores everything from logistical aspects of the fertility journey such as self advocacy and the deeper, very powerful effects of spirituality and manifestation. Michelle happens to have a great sense of humor and brings a lightness to the conversation with her hilarious anecdotes. Whether you're going through fertility treatments or supporting someone who is, this episode offers a powerful mix of vulnerability, wisdom, and inspiration.In this episode, you will learn:How Michelle's fertility experience shaped her work in improving patient careThe emotional impact of IUI, IVF, pregnancy loss, ectopic pregnancy and hormone treatmentsWhy compassion and validation matter in fertility treatmentThe power of mindset, self-advocacy, and community in fertility journeysMichelle's inspiring story of becoming a mom—and the unexpected miracle that followedTimestamps:[0:26] Meet Michelle and her work in hospitality and patient experience[2:17] Empathy gaps in fertility care and what to say instead of “I know how you feel”[8:45] Michelle's fertility journey begins and her first pregnancy loss[15:04] IUI struggles, Clomid side effects, and switching to Letrozole[18:25] Going all in with IVF and lifestyle changes[23:12] Embryo loss, emotional lows, and staying committed[26:41] The B embryo transfer—and the long wait[28:35] The call that changed everythingMichelle's info:https://www.instagram.com/mc_szmajda/?next=%2Fhttps://www.linkedin.com/in/michelleszmajda/https://justthinkhospitality.com/

Polycystic Ovarian Syndrome is more common than most people realize and with more far-reaching implications than it would initially seem. Guest co-host Robyn Flynn joins Dr. Chris Labos to talk about it's potential impact on fertility, cardiovascular health, and according to Robyn, that it's more painful than childbirth?!? We're going to have to look into that one.   You can also check out Robyn's podcast, Rebel Mom Boss https://open.spotify.com/show/4uMAsJS9ySR47iGYw8ExDo?si=bc68ddfcb0bd4f3f    Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at thebodyofevidence@gmail.com.   Editor:    Robyn Flynn Theme music: “Fall of the Ocean Queen“ by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris not your doctor (probably). This podcast is not medical advice for you; it is what we call information.   References: 1) Dutch Twin study about the role of genetics in PCOS:   10.1210/jc.2005-1494   2) Cochrane review on meds that improve fertility https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003053.pub6/full   3) RCT of diet to restore fertility https://academic.oup.com/jcem/article-abstract/88/2/812/2845309?redirectedFrom=fulltext   4) Benefits of weight loss prior to fertility treatment 10.1210/jc.2016-1659 5) Letrozole vs. clomiphene for fertility treatment https://www.nejm.org/doi/full/10.1056/NEJMoa1313517 6) Metformin as a fertility treatment 10.1001/jamanetworkopen.2020.11995  

Dr. Natalie Crawford discusses PCOS treatment options, emphasizing the importance of understanding the normal ovulation process. Letrozole is a common treatment for PCOS, working by reducing estrogen levels to stimulate FSH production. She advises monitoring with ultrasounds and progesterone levels. For those not responding to Letrozole, Clomid may be considered. Dr. Crawford also highlights the role of lifestyle changes, including diet, exercise, and stress reduction, in managing PCOS. She mentions the potential benefits of GLP-1 agonists for weight loss and insulin resistance, though they should be discontinued before attempting pregnancy. Want to receive my weekly newsletter? Sign up at nataliecrawfordmd.com/newsletter to receive updates, Q&A, special content and my FREE TTC Starter Kit and Vegan Starter Guide! Don't forget to ask your questions on Instagram for next week's For Fertility's Sake segment when you see the question box on Natalie's page @nataliecrawfordmd. You can also ask a question by calling in and leaving a voicemail. Call 657–229–3672 and ask your fertility question today!      Thanks to our amazing sponsors! Check out these deals just for you: Quince- Go to Quince.com/aaw for free shipping on your order and 365-day returns Ritual-Go to ritual.com/aaw to start Ritual or add Essential For Women 18+ to your subscription today. Rula - Go to Rula.com/aaw and take the first step towards better mental health today. Aquatru - Go to aquatru.com and use the code AAW for 20% OFF any AquaTru purifier! If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every Sunday. Plus, be sure to follow along on Instagram @nataliecrawfordmd, check out Natalie's YouTube channel Natalie Crawford MD, and if you're interested in becoming a patient, check out Fora Fertility. Learn more about your ad choices. Visit megaphone.fm/adchoices

So, let's talk about polycystic ovarian syndrome (PCOS) and why understanding it is crucial for women's fertility and health… Did you know that 1 in 10 women of reproductive age are affected by polycystic ovarian syndrome? Commonly known as PCOS, this condition that involves hormone imbalances disrupts ovulation, leads to insulin resistance, and can increase risks of miscarriage and pregnancy complications. It affects a lot of women, and yet, many still don't understand how and why it's a problem that needs intervention. That's why in this episode, we'll break down the facts about PCOS, debunk myths, and explore treatment options to help women take control. Whether you're dealing with irregular periods, weight gain, or fertility struggles, tune in and learn how you can help someone you care about on the path to better well-being and fertility. Why you need to check this episode: - Understand how PCOS impacts 1 in 10 women of reproductive age, influencing hormone balance, ovulation, and overall fertility; - Discover the link between insulin resistance, chronic inflammation, and elevated androgen levels that exacerbate PCOS symptoms; - Recognize the importance of early diagnosis through lab work, hormone tracking, and ultrasounds to identify irregularities and improve outcomes; - Learn about lifestyle strategies like weight management, stress reduction, and avoiding environmental toxins to mitigate PCOS symptoms; and - Explore medical treatments, including ovulation-inducing medications like Clomid and Letrozole, to support fertility and symptom management. “Definitely, [there's] some options there. So, it is not a dead-end street when talking about PCOS, when talking about fertility. But the problem is that a lot of people don't know where the road is, and you won't know where the road is unless you're driving, right? So, what have you got to do? You got to drive to the doctor's office. You got to ask the appropriate questions and be able to be open with your doctor if they ask you, hopefully, appropriate questions, so you can give appropriate answers.” – Dr. Berry Pierre Notable Quotes: “One in 10 women of reproductive age are affected by PCOS…So, this isn't like a disease that very few people get. This disease affects a lot of women.” – Dr. Berry Pierre “One of the things I do, especially when I was teaching my students, or with medical residents, I say, we don't order tests because we're hoping for an answer and then we'll kind of figure out our diagnosis. We're ordering a test…to confirm our diagnosis, which is a different ballgame. I'm not just willy-nilly ordering a test just to order it. I'm ordering that test because I assume you have this problem and I want to confirm if it's true with the results.” – Dr. Berry Pierre Mentions: The Myths of Fertility in Men Sign up at www.listentodrberry.com  to join the mailing list. Remember to subscribe to the podcast and share the episode with a friend or family member. Listen on Apple Podcast, Google Play, Stitcher, Soundcloud, iHeartRadio, and Spotify

Dr. Natalie Crawford answers voicemail questions about TTC and fertility.  Questions Answered: If you do a frozen embryo transfer and get pregnant, and you continue tracking your basal body temperature, if you have a large decrease in your basal body temperature, does that mean anything? And should you just stop tracking at all after you do have success and get pregnant with your basal body temperature to decrease any anxiety? Could working overnight and day shifts as a nurse impact my trying to conceive journey? When should I be talking to my doctor about my light periods after stopping birth control? What pre-screenings could my husband or I do? I usually have cycles that range from 45 to 48 days. I've been tracking my ovulation at home, and it seems I'm ovulating around day 33. Should I be concerned about this cycle length? I've been trying to conceive for about 10-11 months. Everything is good on my end and my husband's end. They recently prescribed me Letrozole and said I can do timed intercourse with that, or I could do an IUI this cycle. What would you recommend? Want to receive my weekly newsletter? Sign up at nataliecrawfordmd.com/newsletter to receive updates, Q&A, special content and my FREE TTC Starter Kit and Vegan Starter Guide! Don't forget to ask your questions on Instagram for next week's For Fertility's Sake segment when you see the question box on Natalie's page @nataliecrawfordmd. You can also ask a question by calling in and leaving a voicemail. Call 657–229–3672 and ask your fertility question today!      Thanks to our amazing sponsors! Check out these deals just for you: Quince- Go to Quince.com/aaw for free shipping on your order and 365-day returns Ritual-Go to ritual.com/AAW to start Ritual or add Essential For Women 18+ to your subscription today. Hello Fresh - Get 10 FREE meals at HelloFresh.com/aaw. Uncommon Goods - Go to uncommongoods.com/aaw for 15% off your next gift. Calm - Go to calm.com/aaw for 40% off a Calm premium subscription. If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every Sunday. Plus, be sure to follow along on Instagram @nataliecrawfordmd, check out Natalie's YouTube channel Natalie Crawford MD, and if you're interested in becoming a patient, check out Fora Fertility. Learn more about your ad choices. Visit megaphone.fm/adchoices

Fertility and Sterility On Air brings you the best of ASRM 2024! In Part 2, our hosts bring you: home semen testing with Dan Greenberg (0:40), state insurance mandates for fertility coverage with Adeola Adeyeye (7:13), resource utilization difference between programmed and natural transfers with Ben Peipert (12:23), patient perspectives on embryo donation with Deb Roberts (21:37), corpus lutea and preeclampsia risk after embryo transfer with David Huang (35:02), exercise during stimulation with Maren Shapiro (40:57), combination of letrozole and clomiphene with Rachel Mejia and Jessica Kresowik (49:07), the impact of Alabama's personhood bill with David Monroe (54:06), and embryo quality and polygenic risk with Jordan O'Donnell (58:40). View Fertility and Sterility at https://www.fertstert.org/  

Welcome to The Wholesome Fertility Podcast! Today, I'm addressing an important topic that has come up frequently in my office: fertility-friendly lubricants. Many people don't realize that certain lubricants can negatively affect sperm movement and reduce the chances of conception.   In this episode, I discuss the common issue of vaginal dryness, especially when using fertility medications like Clomid or Letrozole, and how this can be an added challenge for those trying to conceive. I also explore natural ways to boost cervical mucus production, including staying hydrated and making dietary adjustments to improve moisture levels in the body. Additionally, I'll be highlighting fertility-friendly lubricant brands such as Pre-Seed and Good Clean Love, and why choosing products that mimic natural cervical mucus is so crucial.    If you're trying to conceive, this information will help you optimize your chances and ensure you're not unknowingly using something that could hinder your fertility.   Takeaways: Avoid harmful lubricants: Most standard lubricants can be toxic to sperm or slow their movement, which can impact conception. Natural cervical mucus is ideal: Keeping hydrated and consuming foods rich in omega-3s and antioxidants like vitamin C can help increase your body's natural moisture levels. Fertility-friendly lubricants to consider: Products like Pre-Seed, Good Clean Love, and Premom are formulated to be sperm-friendly and closely mimic natural cervical mucus. Vaginal dryness and medications: Fertility medications such as Clomid and Letrozole may cause dryness, making it important to find safe solutions that support sperm health.     Check out Michelle's latest book here: https://www.michelleoravitz.com/thewayoffertility   For more information about Michelle, visit: www.michelleoravitz.com   The Wholesome FertilityFacebook group is where you can find free resources and support: https://www.facebook.com/groups/2149554308396504/   Instagram: @thewholesomelotusfertility   Facebook: https://www.facebook.com/thewholesomelotus/     Transcript:   [00:00:00] Welcome to the Wholesome Fertility Podcast. Today I'm going to be talking about something that I have not talked about yet, but it is an important topic because I've had a lot of people in my office come in and ask me about the specific topic. And a lot of times it is very important when it comes to fertility because People often don't realize that there are certain things that can actually be harming your fertility. So stay tuned because you're not going to want to miss this. So today I'm going to be talking about lubricants. This is actually a very common thing that people use lubricants and they don't realize that the majority of lubricants are actually not great for sperm. They're either toxic for sperm or they can impact how the sperm travels and slow down the traveling and fertilization of the egg. [00:01:00] So when it comes to fertility. It's a completely different ballgame, and it's really important to choose lubricants, if necessary, that are sperm friendly. So today I will be talking all about that. So first of all, I wanted to start out by saying, talking about why women can be dry, and sometimes it really is a cervical mucus thing, and And where it comes to cervical mucus, there are definitely things that you can do to impact cervical mucus naturally, but not just cervical mucus. It's also when taking certain fertility medications such as Clomid or Letrozole, those two medications can impact vaginal dryness as well. And this can be extremely frustrating when people are trying to conceive and women are having to have the difficulty and discomfort of vaginal dryness. And at the same time also timed [00:02:00] intercourse. So it kind of puts a whole other challenge to the whole challenging situation to begin with.   So according to fertility and sterility, Vaginal dryness has actually been reported in about at least 46 percent of all reproductive aged women, which is actually really high considering. So this is really important because when it comes to baby making, it's really important that a woman feels comfortable because if a woman is dry, it can cause more irritation. It can even cause bleeding. And we don't want that because when that's the case, then you're feeling more stress in really trying to conceive. So many times people will want to find lubricants and they'll find things that are over the counter or certain products that they don't realize are actually harming the sperm. So they're using this and I've had people come in and say that they've dealt with it. the discomforts of vaginal dryness[00:03:00] and didn't really realize, but for the whole time they've been trying and sometimes it's close to a year they've been using lubricants that are not necessarily great for the sperm and didn't even realize it. So this is why I find it so important in the podcast and in general to give information to people because many times nobody really tells you this stuff. You really think that, okay, what's the big deal? It shouldn't make a difference, but it really does. And the same thing also with figuring out the fertile window. All of these things are typically not things that you learn, not in school and oftentimes not even at the doctor's office. So it is really important to understand your body and understand really like how to optimize your fertile window and how to optimize your chances of conceiving and what those certain things are that can impact. that process. So like mentioned before, [00:04:00] a lot of these lubricants can impact sperm movement and impact how sperm is able to fertilize. And this can obviously be an issue because the sperm needs something that's similar to the cervical mucus, which is why the cervical mucus is so important because it It protects the sperm, but it also is created in a beautiful way to allow the sperm to move as fast as possible and most efficiently so that it is able to get to the egg and fertilize for conception.   Another thing that you want to look at is pH levels and if there's any chemicals in the lubricants that are harmful to sperm. So, ideally, you really want your own body's natural lubricant, which is cervical mucus. And there are a couple of things that you can do to improve that. And then I'll go over some other alternatives if that is not [00:05:00] working. But really what you want to do is increase your, in Chinese medicine speak, yin. Estrogen is a really important hormone in that process during the follicular phase that leads up to ovulation because estrogen is a very yin hormone. Yin is an aspect of the yin and yang that is more moist, more cooling, more feminine. So we want to bring in more moisture and we want to make sure that the body holds in that moisture. So there are definitely things that you can do to improve that and the first thing and it's the most obvious thing and I've seen it be the single handedly like the easiest way for people to improve cervical mucus is hydration. You would be shocked At how important it is to just hydrate because cervical mucus is majority is water. It really consists of water. And so if somebody is dehydrated and I've had a lot of people in the healthcare industry[00:06:00] that come in as patients, they just say they don't have time to drink. And I really push them on this because eventually they can actually shift that. It's just easier not to drink. So it's not that you can't drink. It's just that it. Tends to be easier and then it becomes a bad habit. So a lot of these people that are nurses, a lot of people that are dentists that are in the healthcare field don't really feel like they have an option. I work with them on that and they do change that. So it is possible. Anything's possible.   It's just a matter of putting a little more effort to get in the habit. We're just have water with you to just ensure that you're having it and also having water in the morning. , listen, you know, it might be a little inconvenient to have to go to the bathroom a couple of times extra, but it is really important and it really can impact your cervical mucus in a huge way. I've had people that have noticed vaginal dryness and that they've also had many times where [00:07:00]they were not seeing the same kind of cervical mucus that they used to see when they were younger. And all they did was increase the hydration. and that within a couple of months really shifted things and they started to see it. They actually saw when they wiped that they had more cervical mucus and more like egg white consistency on the peak days. So that is actually a very easy way to do this. And as a rule of thumb, you want to take whatever your weight is in pounds, take that number, divide that in half, and that amount in ounces is what you want you know, to drink every day. So say you're 120 pounds. So divide that by half, that's 60. So you take 60 ounces per day is the rule of thumb of water. And ideally you have that in containers that are not plastic. So either glass or stainless steel. And then also make sure to filter that [00:08:00] water. So you know, just kind of a side note, I always talk about that with my patients. So that's really, really important is to increase hydration and part of hydration also is not just water is from time to time to make sure that you're getting electrolytes as well. You also want healthy carbohydrates. So carbohydrates can also help and carbs can help the yin aspect of our body. So it helps your body absorb and , keep itself hydrated. So that you're able to retain a little bit more water because that water is important to retain in order to hydrate your body in many different ways, including cervical mucus. Another really important vitamin that impacts cervical mucus is actually vitamin C. And you can also increase citrus fruits in your diet. This is something that has been shown to improve. cervical mucus. So these are things that you want to do naturally. Ideally, if you could do things naturally, then you're using your own body's [00:09:00] natural lubricant, which is optimized for sperm health and to protect sperm and to help the chances of conception. So ideally you want to try to get it where your body's doing this. Another important antioxidant is vitamin E as well. And that can help regulate estrogen in your body.   You also want to get foods that are rich in omega 3s. Omega 3 fatty acids are really great for cervical mucus. And if you think about it, just oils in general, healthy oils. So, things like coconut oil that you're taking internally. I know some people use it physically, like as lubricant. I'm not a huge fan, but, Take things oils internally because when you're increasing those oils, which are very Yin substances, you're also improving your own body's ability to moisten itself. And you can also get, , those oils through nuts and [00:10:00] seeds, which are very rich in what we call in Chinese medicine, Jing. Jing is really fertile essence. It's really essence of the body. Okay. And if you think about seeds or nuts, they're basically seeds ready to sprout, which is ultimately like what egg and sperm are. So they're fertile, they're fertile by nature, and they have everything that they need and all the resources within it's the seed in order to fertilize and become fertile. So you want things in nature to borrow from so that it improves your own ability to fertilize as well, which of course is conception.   So, here are things to consider if you were to buy fertility friendly lubricants. So, you want to find something that's water based so that it doesn't decrease sperm motility  because that would be the most similar consistency to natural cervical mucus. You also want lubricants that are free[00:11:00] from parabens, fragrances, or any kind of chemicals, and ultimately to be the closest mimicking of natural cervical mucus.  And here are some brands that are the most fertility friendly. And the first one is precede fertility lubricant. You'll see that very often it's available on Amazon, many different places. And then also good clean love biogenesis fertility lubricant. Another one is conceived plus fertility lubricant. And there's also Nautilus, the lube lubricant. And there are many different ones that you'll see. You'll also see Lola, fertility friendly lube, penchant organic. So these are things that you want to definitely look up and make sure that it says fertility friendly. And I always recommend just do your own research and really look into it. Look at the [00:12:00] reviews and find what you think is best for you but ultimately, like I said before, the best thing that you can do is try to get your own natural lubricants going, especially during the fertile window. If you have that a little bit more than, And I also recommend having sex outside of the fertile window.   I often recommend that. And in that case, you don't have to worry quite as much. I still would use natural ones though, personally, because also when your body receives the sperm outside of the fertile window, then it will, lower its immunity so that you are able to receive the sperm because it's considered like an invader through the body.   So you're able to really lower the immune system, which typically would happen in the second part of the menstrual cycle, which is the luteal phase that you're able to receive the sperm. So the more access your body has, or the more interaction it has with a [00:13:00] sperm, even if it's outside of the fertile window into the luteal phase, the more it becomes open to receiving it. And another plus for that is just really being able to connect outside of the fertile windows so that there's no timing on it. And it really is something that you can put towards your relationship with your partner so you can have that connection. And ultimately that is such an important part of the whole process because I know so many people tell me.   And express how difficult it is to have to. put the pressure of timing and when they could do it. And when you open it up to more of a larger window outside of it, there's less added pressure and there's more time for connection. And as I mentioned this in my book, the way of fertility, which I highly recommend you check out because a lot of the things that I talk about are [00:14:00] all bundled up in there described perfectly because I repeat myself a lot. And this is one of the reasons I wrote the book is because I wanted to put all of my ideas and thoughts and all of my findings and lots of the information that I got from, , ancient wisdom and really the basis of Chinese medicine into a book where you can find it with exercises. But I talk about the connection between the partners and really having that connection because when you do have that connection and you really feel turned on, you will naturally also produce more natural lubricant.   So those are natural processes of the body, but it all starts with the mind. So a lot of it really starts psychologically and it's It's about connecting, opening the heart. So I talk a lot about that in the book. You can look at the episode notes to find out more on how to get that. And I will also list these fertility friendly lubricants that I mentioned in the episode[00:15:00] notes. And you can always reach out to me. on Instagram. I'm always there and my handle is at the wholesome Lotus fertility. If you have any questions you want to reach out, you can find me there. So thank you so much for tuning in today and I hope you have a beautiful day. 

Dr. Natalie Crawford addresses a question from an OB/GYN colleague about managing patients with unexplained infertility and high AMH levels. She explains that unexplained infertility is often due to undiagnosed issues, and a full workup is necessary to understand the underlying causes. The episode delves into the mechanisms of ovulation induction medications like Clomid and Letrozole, which are commonly used to induce ovulation in patients with conditions like PCOS. Throughout the episode, Dr. Crawford emphasizes the importance of patient advocacy and education, encouraging patients to ask questions, understand the reasons behind treatment recommendations, and seek a second opinion if they feel their current treatment plan is not effective or appropriate. Want to receive my weekly newsletter? Sign up at nataliecrawfordmd.com/newsletter to receive updates, Q&A, special content and my FREE TTC Starter Kit! Don't forget to ask your questions on Instagram for next week's For Fertility's Sake segment when you see the question box on Natalie's page @nataliecrawfordmd. You can also ask a question by calling in and leaving a voicemail. Call 657–229–3672 and ask your fertility question today!      Thanks to our amazing sponsors! Check out these deals just for you: Quince- Go to Quince.com/aaw for free shipping on your order and 365-day returns Ritual-Go to ritual.com/AAW to start Ritual or add Essential For Women 18+ to your subscription today. If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every Sunday. Plus, be sure to follow along on Instagram @nataliecrawfordmd, check out Natalie's YouTube channel Natalie Crawford MD, and if you're interested in becoming a patient, check out Fora Fertility. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this heartfelt episode, Jacqueline starts off by sharing the deeply personal story behind the inception of her podcast 'Motherhood Intended,' following the loss of her daughter Maren. Through her grief, Jacqueline found strength and inspiration to create a platform that supports mothers navigating infertility and motherhood. This episode features an engaging conversation with guest Colleen, who details her infertility journey due to PCOS, her experience with functional medicine, and her role as a co-founder of a children's book publishing company. The episode highlights the importance of self-advocacy in healthcare, the therapeutic value of sharing personal stories, and the intersection of Western and functional medicine in addressing infertility. Tune in for stories of resilience, valuable insights on managing PCOS, and a celebration of empowered mothers.GET CONNECTED TO THE PODCAST:Sign up now for the Motherhood Intended Email List!Join our FREE Motherhood Intended CommunityFollow @motherhood_intended on InstagramLeave a review for the podcastApply to be a guest on the showCHECK OUT CAMPUS A-Z BOOKS!Available for purchase on their website and Amazon!Send us a Text Message with questions, suggestions, or to just say hello!This episode is sponsored by Restful Baby.Aly Dabbs is a certified sleep consultant and the founder of Restful Baby. She helps struggling moms get back the rest they need. Aly gives you the tools and support you deserve to create a successful and peaceful sleep routine for your toddler. You do not need to accept exhaustion as your new normal! Podcast listeners get $50 off a sleep package, so set up your consult with Aly today!Support the showIf you're interested in helping give the absolute greatest gift to deserving intended parents, learn more about becoming a surrogate (and earn up to $650 just for taking the first few simple steps!): share.conceiveabilities.com/hello12

Send us a Text Message.Millennial moms have grown up in the depths of diet culture - and that has had a huge impact on the relationships many of us have had with our bodies. In this episode, confidence and self-love coach and heels dance instructor Lindsay Tompkins is joining the podcast for a discussion on body confidence, generational healing, and navigating health. In the episode Lindsay and I talk about: What it means to be confident as an action instead of an end goalHow diet culture and generational patterns have impacted millennial women's body imagesBody image postpartumHow health struggles can impact body confidenceWhy the health care system needs to stop focusing so much on weightA little about our guest:Lindsay Tompkins is a body confidence and self-love coach and heels dance entrepreneur. She is a first time mama to a cheeky 2 year old boy she conceived through Letrozole. Lindsay has PCOS, hypothyroidism and hashimotos, and is a Hyperemesis Gravidarum Mama. All of which has played a role in her relationship with her body and confidence! Through coaching, therapy and dance, she has learned to better navigate the ebbs and flows of diet culture and find love and kindness for her body, for both herself and her son. To connect with Lindsay, follow her on Instagram @confidencewithlinds.If you found this episode valuable, share it with other moms in your life. Follow along with The Worthy Mother Podcast on Instagram @emily.rose.hardy and @worthymotherpodcast, and don't forget to subscribe wherever you listen!

Many patients ease into fertility treatment with simple medications such as clomiphene or letrozole. Join Dr. Carrie Bedient from The Fertility Center of Las Vegas, Dr. Abby Eblen from Nashville Fertility Center and Dr. Susan Hudson from Texas Fertility Center,  as they discuss the basics of ovulation induction treatments using Clomid and Femara. They review how each medication acts and which patients benefit most by these treatments. The Fertility Docs outline differences in ovulation induction with OB/Gyns vs. REIs, and the pros and cons of these treatments. Join us as we discuss some of the most readily accessible and affordable fertility treatments available! Have questions about infertility?  Visit FertilityDocsUncensored.com to ask our docs. Selected questions will be answered anonymously in future episodes.Today's episode is brought to you by Needed and Path Fertility 

Send us a Text Message.What if you received a life-changing diagnosis despite being at the peak of your health, managing a successful career, and having no family history of the disease? Join us for an inspiring conversation with Ellyn Winters, who shares her rollercoaster journey from high-functioning PR mogul to breast cancer survivor and advocate. Ellyn's story is a testament to resilience and the transformative power of facing life's unexpected challenges head-on.Ellyn opens up about her decision to undergo a double mastectomy with aesthetic flat closure, courageously opting out of breast mound reconstruction, and the grueling process of chemotherapy and radiation treatments. She also dives into the emotional and physical hurdles she faced, including the impact of lymph node involvement and medications like Letrozole. Ellyn's advocacy work shines through as we highlight her groundbreaking topless feature in People Magazine post-surgery and her co-created app https://askellyn.ai/, an empathetic AI companion designed to support breast cancer patients and their families. We explore how this innovative tool, built from OpenAI technology and Ellyn's personal experience, offers non-judgmental support while urging users to consult their medical professionals. Ellyn discusses the AI's global reach and the move to a nonprofit model, emphasizing the importance of empathy and the common healthcare challenges patients face, particularly in Canada. Tune in to learn about the strength in survivorship and the systemic changes needed to better support those battling breast cancer.519-574-2196ellyn@lyndallproject.comFlat Please on Instagram Twitter @flat_please Ellyn Winters on LinkedinAskEllyn on Facebook  Ellyn Winters in People Magazinehttps://densebreastscanada.ca/ https://densebreastscanada.ca/photo-essays/Lyndall ProjectElly Are you loving the Test Those Breasts! Podcast? You can show your support by donating to the Test Those Breasts Nonprofit @ https://testthosebreasts.org/donate/ Where to find Jamie:Instagram LinkedIn TikTok Test Those Breasts Facebook Group LinkTree Jamie Vaughn in the News! Thanks for listening! I would appreciate your rating and review where you listen to podcasts!I am not a doctor and not all information in this podcast comes from qualified healthcare providers, therefore may not constitute medical advice. For personalized medical advice, you should reach out to one of the qualified healthcare providers interviewed on this podcast and/or seek medical advice from your own providers .

Chest pains and severe fatigue drove Valerie David to seek medical attention, which led to a diagnosis of Stage 3B Cell Diffuse Large Cell Non-Hodgkin's Lymphoma.  A chemotherapy regimen helped her achieve survivorship.  However, years later, she discovered a lump under her armpit.  After getting it checked out, she was diagnosed with Stage 2 Invasive Lobular Carcinoma, a form of breast cancer. Again, aided by a chemotherapy regimen, Valerie survived this diagnosis, but not long after that, she was diagnosed with Stage 4 metastatic breast cancer.  Despite the staging, Valerie was prescribed a less aggressive form of chemotherapy, and survived.  Inspired by her cancer journey, she written and starred in an award-winning one-woman play, “The Pink Hulk,” seen through the United States and in Europe.

In this month's Fertility & Sterility: Unplugged, we take a look at articles from F&S's sister journals! Topics this month include: IVF in film (3:03), a rat model of fallopian tube torsion (12:25), comparing letrozole regimens for PCOS (24:13), and a review of chronic endometritis (36:46). Consider This: https://www.fertstert.org/news-do/evaluation-accuracy-and-portrayal-vitro-fertilization-film F&S Science: https://www.fertstertscience.org/article/S2666-335X(24)00018-1/abstract F&S Reports: https://www.fertstertreports.org/article/S2666-3341(24)00045-X/fulltext F&S Reviews: https://www.fertstertreviews.org/article/S2666-5719(24)00006-9/abstract   View the sister journals at: https://www.fertstertreviews.org https://www.fertstertreports.org https://www.fertstertscience.org  

ResourcesBronson R. and Kruljac I, Butorac D, Vrkljan M. and Legro RS, Zhang H; Eunice Kennedy Shriver NICHD Reproductive Medicine Network. Letrozole or clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(15):1463-1464. doi:10.1056/NEJMc1409550Centers for Disease Control and Prevention. PCOS (Polycystic Ovary Syndrome) and Diabetes. https://www.cdc.gov/diabetes/basics/pcos.html. Accessed April 21, 2024.Franik S, Kremer JA, Nelen WL, Farquhar C. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2014;(2):CD010287. Published 2014 Feb 24. doi:10.1002/14651858.CD010287.pub2Franik S, Le QK, Kremer JA, Kiesel L, Farquhar C. Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2022;9(9):CD010287. Published 2022 Sep 27. doi:10.1002/14651858.CD010287.pub4Legro RS, Brzyski RG, Diamond MP, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome [published correction appears in N Engl J Med. 2014 Oct 9;317(15):1465]. N Engl J Med. 2014;371(2):119-129. doi:10.1056/NEJMoa1313517Legro RS, Diamond MP, Coutifaris C, et al. Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins. Fertil Steril. 2020;113(5):1005-1013. doi:10.1016/j.fertnstert.2019.12.023Palomba S, Santagni S, Falbo A, La Sala GB. Complications and challenges associated with polycystic ovary syndrome: current perspectives. Int J Womens Health. 2015;7:745-763https://doi.org/10.2147/IJWH.S70314World Health Organization. Polycystic Ovary Syndrome. World Health Organization; 2023. Accessed April 21, 2024. https://www.who.int/news-room/fact-sheets/detail/polycystic-ovary-syndromeZhang H. Pregnancy in Polycystic Ovary Syndrome II (PPCOSII). ClinicalTrials.gov identifier: NCT00719186 . Updated June 14, 2018. Accessed April 20, 2020. https://classic.clinicaltrials.gov/ct2/show/NCT00719186

Get your FREE copy of “Your A-Z Guide to Staying Cancer Free” here: https://bit.ly/azcancerfree   Which is better ANASTROZOLE or LETROZOLE?   Many breast cancer survivors wonder why they were put on one drug, while other women were put on another. PLUS - if you are having side effects on one maybe your life could be better on the other.   In this episode of the Cancer Freedom Podcast, I'm showing you the difference between ANASTROZOLE and LETROZOLE   So let me show you how it's done.   Join the Cancer Freedom Program Click HERE https://bit.ly/CFPYT   #cancerfighter #cancersurvivor #breastcancer #breastcancersurvivors #cancerrecovery  #cancernutrition #mastectomy #tamoxifen #anastrozole #letrozole #exemestane    ***PS - Whenever you're ready, here are the 2 best ways I can help you… 1) “Your A-Z Guide to Staying Cancer Free” Click HERE https://bit.ly/azcancerfree   2) Join the Cancer Freedom Program Click HERE https://bit.ly/CFPYT   ***Let's Connect: Website: www.cancerfreedomprogram.com Instagram: https://www.instagram.com/dramymorris/ TikTok: https://www.tiktok.com/@dramycancerrecovery YouTube: https://www.youtube.com/channel/UCUt9... Facebook: https://www.facebook.com/amydeepharmd  

In today's episode, we had the pleasure of interviewing Jordan, a midwife and first-time mum who made the decision to birth her baby at home. We chat to Jordan about her journey to conceive which involved taking Letrozole to help support ovulation. Jordan shared her experience of a swift 6-hour labour, culminating in the beautiful birth of her son in a birth pool. Notably, Jordan encountered a unique challenge during the third stage of labor, as she experienced Vasovagal Syncope while attempting to deliver the placenta. This occurrence was attributed to the presence of a bilobed placenta situated behind her cervix, a condition known as Cervical Shock Syndrome. Our discussion further delved into Jordan's profound thoughts and emotions surrounding the hospital system, as well as the reasons that guided her decision to embrace the path of a homebirth. Join us as we explore the intricacies of Jordan's experience, gaining valuable insights into the world of midwifery and the transformative power of making informed choices during the birthing process.Jordan documented her whole pregnancy and birth on her instagram page  - Fromwomb_toworld Links:Photographer - Caitlyn Hands (Stemmer)  - Earthchild.photography Hunter Valley Homebirthers Facebook group Coulton Stoliar, S., Dahlen, H. G., & Sheehan, A. (2023). A national survey of Australian midwives' birth choices and outcomes. Women and Birth, 36(2).Coulton Stoliar, S., Dahlen, H. G., & Sheehan, A. (2022). Insider knowledge as a double-edged sword: an integrative review of midwives' personal childbearing experiences. BMC pregnancy and childbirth, 22(1), 640. PANDA https://treasury.gov.au/sites/default/files/2021-05/171663_perinatal_anxiety_and_depression_australia.pdfBlack Dog Institute Gidget FoundationSupport the show@homebirthstoriesaustralia Please be advised that this podcast may contain explicit language. Listener discretion is advised.The information, statistics, and research presented in this podcast are for informational purposes only and are not intended to constitute or replace medical or midwifery advice. All information discussed can be found online and is provided in the links in the show notes. It is always recommended to conduct your own research and make informed decisions. We advise you to discuss any topics or concerns with your healthcare provider. While we strive to incorporate the most up-to-date research in our episodes, we do not warrant or guarantee the accuracy of the information discussed on the show.

Prepare for an extraordinary week ahead with Egg Meets Sperm's insightful fertility tip episodes!  We're starting the week with a deeply meaningful topic: "PCOS and Fertility: What to do when Letrozole doesn't work." Get ready to be captivated and motivated by the exceptional Dr Angela Potter as she shares her profound insights and invaluable perspectives in every tip episode!  Stay tuned, invite your friends, and let's make this week filled with fertility wisdom, and empowerment!  Dr Angela Potter is a leading expert in PCOS fertility. She is the creator of the PCOS Fertility Protocol which helps women like you get an individualized fertility plan so you can have the best chance at becoming pregnant. Dr. Potter is also a speaker and has shared the stage with leaders from companies like Google and Microsoft. Gift to listeners:  Free PCOS Fertility Breakthrough Session at drangelapotter.com/eggmeetssperm   Follow Dr Angela on:  Facebook.com/drangelapotter Instagram: @drangelapotter   Follow me on: Instagram: @holisticfertilitydoctor TikTok:  @holisticfertilitydoctor Youtube:  @Holistic Fertility Expert Facebook: Join our private Fertile AF tribe!  

Prepare for an extraordinary week ahead with Egg Meets Sperm's insightful fertility tip episodes!  We're starting the week with a deeply meaningful topic: "PCOS and Fertility: What to do when Letrozole doesn't work," Get ready to be captivated and motivated by the exceptional Dr Angela Potter as she shares her profound insights and invaluable perspectives in every tip episode!  Stay tuned, invite your friends, and let's make this week filled with fertility wisdom, and empowerment!  Dr Angela Potter is a leading expert in PCOS fertility. She is the creator of the PCOS Fertility Protocol which helps women like you get an individualized fertility plan so you can have the best chance at becoming pregnant. Dr. Potter is also a speaker and has shared the stage with leaders from companies like Google and Microsoft. Gift to listeners:  Free PCOS Fertility Breakthrough Session at drangelapotter.com/eggmeetssperm   Follow Dr Angela on:  Facebook.com/drangelapotter Instagram: @drangelapotter   Follow me on: Instagram: @holisticfertilitydoctor TikTok:  @holisticfertilitydoctor Youtube:  @Holistic Fertility Expert Facebook: Join our private Fertile AF tribe!  

LFG!!!!!! Today's guest is a dear friend of Ali's, Ashely Hingston, aka @rage_against_infertilty. Ashley tells Ali all about having PCOS symptoms as a young woman and going on birth control, how certain doctors don't want to work with someone over a certain BMI; and going through letrozole rage. She talks about meeting her husband, Rob, doing medicated cycles and discovering male factor infertility, and recovering from an eating disorder. She talks about joining Fertility Rally; finally finding a clinic and medical team that would work with her, enduring many cycles that ended in failed implantation, and -- SPOILER ALERT -- what happened when they met their surrogate, and finally had their son, Jackson Walter, in early 2024.  TOPICS COVERED IN THIS EPISODE: PCOS; IVF; egg retrieval; ART; BMI; Letrozole; medicated cycles; male factor infertility; surrogacy; surrogacy agencies; surrogacy pregnancy; grieving your pregnancy; IVF success  EPISODE SPONSORS: WORK OF ART Children's Book about IVF https://www.infertileafgroup.com/books Ali wrote her first children's book, and it's available now! “Work of ART” is the story of an IVF kiddo the day he learns he is a “work of ART” (born via IVF and Assisted Reproductive Technology). For young readers 4-8. Hardcover. Written by Ali Prato; Illustrated by Federico Bonifacini. Personalized and non-personalized versions are available. Order yours now at https://www.infertileafgroup.com/books For bulk orders of 10 or more books, go to https://www.infertileafgroup.com/bulk-order-request FERTILITY RALLY @fertilityrally www.fertilityrally.com No one should go through infertility alone. Join the Worst Club with the Best Members at fertilityrally.com. We offer 5 to 6 support groups per week, three private Facebook groups, tons of curated IRL and virtual events, and an entire community of more than 500 women available to support you, no matter where you are in your journey. Join today at link in bio on IG @fertilityrally or at www.fertilityrally.com/membership RECEPTIVA DX ReceptivaDx is the singular test capable of identifying endometriosis, progesterone resistance, and endometritis in one comprehensive analysis. These conditions are often the hidden culprits behind unexplained infertility, directly impacting the success rates of IVF treatments. Ask for the Receptvia DX test today, and use code INFERTILEAF24 for $75 off. Learn more about your ad choices. Visit podcastchoices.com/adchoices Learn more about your ad choices. Visit podcastchoices.com/adchoices

Prepare for an extraordinary week ahead with Egg Meets Sperm's insightful fertility tip episodes!  We're starting the week with a deeply meaningful topic: "PCOS and Fertility: What to do when Letrozole doesn't work." Get ready to be captivated and motivated by the exceptional Dr Angela Potter as she shares her profound insights and invaluable perspectives in every tip episode!  Stay tuned, invite your friends, and let's make this week filled with fertility wisdom, and empowerment!  Dr Angela Potter is a leading expert in PCOS fertility. She is the creator of the PCOS Fertility Protocol which helps women like you get an individualized fertility plan so you can have the best chance at becoming pregnant. Dr. Potter is also a speaker and has shared the stage with leaders from companies like Google and Microsoft. Gift to listeners:  Free PCOS Fertility Breakthrough Session at drangelapotter.com/eggmeetssperm   Follow Dr Angela on:  Facebook.com/drangelapotter Instagram: @drangelapotter   Follow me on: Instagram: @holisticfertilitydoctor TikTok:  @holisticfertilitydoctor Youtube:  @Holistic Fertility Expert Facebook: Join our private Fertile AF tribe!  

Prepare for an extraordinary week ahead with Egg Meets Sperm's insightful fertility tip episodes!  We're starting the week with a deeply meaningful topic: "PCOS and Fertility: What to do when Letrozole doesn't work".  Get ready to be captivated and motivated by the exceptional Dr Angela Potter as she shares her profound insights and invaluable perspectives in every tip episode!  Stay tuned, invite your friends, and let's make this week filled with fertility wisdom, and empowerment!  Dr Angela Potter is a leading expert in PCOS fertility. She is the creator of the PCOS Fertility Protocol which helps women like you get an individualized fertility plan so you can have the best chance at becoming pregnant. Dr. Potter is also a speaker and has shared the stage with leaders from companies like Google and Microsoft. Gift to listeners:  Free PCOS Fertility Breakthrough Session at drangelapotter.com/eggmeetssperm   Follow Dr Angela on:  Facebook.com/drangelapotter Instagram: @drangelapotter   Follow me on: Instagram: @holisticfertilitydoctor TikTok:  @holisticfertilitydoctor Youtube:  @Holistic Fertility Expert Facebook: Join our private Fertile AF tribe!  

This week, we're delving into a topic of significant importance and deep impact: "PCOS and Fertility: What to do when Letrozole doesn't work." We're honored to have the esteemed Dr. Angela Potter join us to share her profound knowledge and invaluable insights on this subject. This episode promises to enlighten and inspire as Dr. Angela Potter explores the complexities behind fertility challenges associated with PCOS. Discover alternative strategies and hopeful pathways for those who find themselves seeking answers when Letrozole, a commonly prescribed treatment, falls short of expectations. Prepare to be engaged, educated, and empowered by the stories, strategies, and science that Dr. Potter will bring to light. Dr Angela Potter is a leading expert in PCOS fertility. She is the creator of the PCOS Fertility Protocol which helps women like you get an individualized fertility plan so you can have the best chance at becoming pregnant. Dr. Potter is also a speaker and has shared the stage with leaders from companies like Google and Microsoft. Gift to listeners: Free PCOS Fertility Breakthrough Session at drangelapotter.com/eggmeetssperm   Follow Dr Angela on:  Facebook.com/drangelapotter Instagram: @drangelapotter   Follow me on: Instagram: @holisticfertilitydoctor TikTok:  @holisticfertilitydoctor Youtube:  @Holistic Fertility Expert Facebook: Join our private Fertile AF tribe!  

Dr. Natalie Crawford answers your voicemail questions about ovulation and ovulation induction. If you do not understand how ovulation works, it's hard to know when things are normal and most importantly when they are abnormal. It also hard to know when your periods are normal or abnormal and what treatments work or don't work for you. Questions answered: I just did my first round of Letrozole and I typically ovulate around day 15 and got a positive ovulation test around day 9. Is this normal? What is the purpose of using Letrozole to boost ovulation? Does Letrozole work for luteal phase deficiency? How many cycles should I do? At my monitoring appointment for medicated IUI, I was told my 25mm follicle was likely too mature. Did I trigger too late?  We have moved Fertility In The News to the weekly newsletter in order to keep the podcast more evergreen. If you want to sign up go to nataliecrawfordmd.com/newsletter to sign up! Don't forget to ask your questions on Instagram for next week's For Fertility's Sake segment when you see the question box on Natalie's page @nataliecrawfordmd. You can also ask a question by calling in and leaving a voicemail. Call 657–229–3672 and ask your fertility question today!      Thanks to our amazing sponsors! Check out these deals just for you: Apostrophe- Get your first visit for only five dollars at Apostrophe.com/AAW or use the code AAW at checkout. Quince- Go to Quince.com/aaw for free shipping on your order and 365-day returns Ritual-Go to ritual.com/AAW to start Ritual or add Essential For Women 18+ to your subscription today. Rocket Money - Cancel your unwanted subscriptions by going to RocketMoney/com/AAW Caraway - Visit Carawayhome.com/AAW to take advantage of this limited-time offer for 10% off your next purchase. HoneyLove- Visit honeylove.com/aaw to get 20% OFF HoneyLove If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every Sunday. Plus, be sure to follow along on Instagram @nataliecrawfordmd, check out Natalie's YouTube channel Natalie Crawford MD, and if you're interested in becoming a patient, check out Fora Fertility. Learn more about your ad choices. Visit megaphone.fm/adchoices

Navigating family planning and women's health during perimenopause with fertility and infertility specialist, Dr. Susan Caldwell.  (4:15) Taking your women's health and fertility questions on: using Letrozole to try and get pregnant, how to support a friend who has been trying to have a baby, would you see a naturopath or a NaPro doctor first if trying to conceive and 35 or older. (29:27) 40 Days for Life! (43:43)   Resources mentioned : NFP support for during perimenopausehttps://pearlandthistle.com/  https://pearlandthistle.podia.com/perimenopause-prep-navigating-nfp-with-shifting-fertility Find a NaPro doctor: https://fertilitycare.org/find-a-mc NaPro Dr. Susan Caldwell episodes library  https://relevantradio.com/?cat=23210&s=dr.+susan+caldwell  Dr. Susan Caldwell  https://www.drsusancaldwell.com/ Find a Creighton Fertility Care Instructor https://mycatholicdoctor.com/providers/fertility-educator/sl-creighton/ 

In today's episode we're hearing from Kat as she shares about the births of her two daughters. She used letrozole to help her conceive her first baby due to amenorrhea and her second was conceived after her first period in 13 years! Despite both babies being born at home, her two births were wildly different experiences; one ended with an episiotomy in an ambulance outside the house and the other in the birth pool with the midwives calmly watching over. We discuss the importance of sharing positive homebirth stories, the power of mother's intuition and the logistics of homebirthing with an older sibling present.   Kat's website: https://katarinarayburnyoga.com/ Kat's IG: https://www.instagram.com/katarinarayburnyoga  My website: www.serenalouth.comMy IG: https://www.instagram.com/serenalouth/ Upcoming hypnobirthing course dates: https://serenalouth.com/hypnobirthing

In this episode of Kiwi Birth Tales, I speak to Milly. Some of the topics we cover:EndometriosisFertility Support - ClomophineHypnobirthingPositive PregnancySpontaneous labourLabour at homeFast second half of labourQuick delivery at birth careFetal Ejection ReflexShock post-birthDifficulty latching | Tongue tieBaby Blues2.5years breastfeedingLetrozole for pregnancy 2nd timeBleeding in pregnancyHyperemesis GravidarumPlacenta PreviaPremature birth due to Haemorrhage at 33 weeksEmergency Csection - vertical incisionSCBUDonor Milk10 days in SCBU then homePlease seek support for any mental health concerns, some helpful links are below:Mental Health in PregnancyPerinatal Depression and Anxiety Aotearoa Plunket - Dads Mental HealthLittle Shadow - Private Counselling NZYour Birth Project Online Hypnobirthing CourseFind me @kiwibirthtales and @yourbirthproject Hosted on Acast. See acast.com/privacy for more information.

Letrozole is an oral, FDA approved, medication used for the treatment of breast cancer. However, by inducing ovulation, it has been found to be effective in helping women with anovulatory infertility conceive. In this episode of Friday Chats, I'm sharing how this drug works, what the science is saying (spoiler alert: it's more effective than Clomid!), and its potential side effects. --- Fullscript Supplement Dispensary

What we tailed about 1. Question from Kate: She's been eating well all summer, working out five times a week (including three HIIT classes and two yoga sessions), but hasn't seen any change on the scales. She wonders if it's peri menopausal and if she should see a doctor, especially as she's trying to conceive and prepare for IVF. There could be various factors affecting weight, including diet tracking, the type of exercises, and stress. HIIT classes might not be ideal before IVF due to the stress they place on the body. It's essential to consider the consistency of workouts and overall stress levels. It doesn't necessarily mean it's perimenopause. Monitoring progress through photos or clothing fit might be more indicative than scales. Muscle gain could offset fat loss, making scales misleading.2. Question from AJ in San Diego: What are the signs of infertility? Infertility can manifest in various ways. Common signs include trying to conceive for a year without success, irregular or absent menstrual cycles, abnormal bleeding, and significant pain or discomfort during periods. Tracking menstrual cycles can provide insights. In the UK, the standard measure is if one has been trying for a year without becoming pregnant.3. Question from Mira in Leicester: She has PCOS and doesn't ovulate regularly. She's hoping her doctor will prescribe Clomid or Letrozole. Which is better? Both Clomid and Letrozole aim to stimulate ovulation. Letrozole reduces estrogen production, leading to an increase in FSH, which stimulates the ovaries. It might be more effective than Clomid, especially for women with PCOS. Clomid blocks estrogen receptors in the brain, leading to increased secretion of FSH and LH, stimulating the ovaries. However, Clomid can have side effects like thickening cervical mucus and thinning the uterine lining. Letrozole might have fewer side effects. It's essential to consult with a doctor to determine the best option.4. Question from Roisin: What was your first podcast, and do you have any recommendations? Maria's first podcast was the "Spartan Up Podcast," related to fitness. She also recommends the "Nike Trained" podcast. Another recommendation is "The Retrievals," which focuses on the egg collection experience. Rosin started with "Serial," a true crime podcast, and also recommends "Undisclosed," "Dirty John," "Shrink Next Door," and "Search Engine" by PJ Vogt.Thank you for tuning in to this week's episode of the Fitness Fertility Podcast. Remember to subscribe for weekly updates, leave a comment, and share with friends. Your safety and well-being are our priorities, so always consult with your doctor before starting any exercise or nutrition program. To find Maria go to: www.fitnessfertility.comThis has been a Worth A Listen ProductionDISCLAIMER: The content in the podcast and on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. It is essential to always seek the advice of your doctor or qualified healthcare provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or read on the website www.fitnessfertility.com. Your health and well-being are paramount, and it is crucial to make informed decisions with the guidance of a healthcare professional. DISCLAIMER: The content in the podcast and on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

Dr. Natalie Crawford answers the voicemails you called in. 1. My husband is a long time smoker who gave cigarettes up for vaping. His sperm parameters are all normal but should I be worried about anything else regarding his semen when it comes to embryo banking? I also have diminished ovarian reserve. 2. When is it best to take Letrozole while doing timed intercourse? What is the best protocol for the trigger shot? 3.Could my ovarian cysts be contributing to high progesterone in the follicular phase? 4. What are the treatment options for recurrent pregnancy loss? 5. If an egg is immature but successfully fertilizes, can it make it to the embryo stage and be genetically normal? We have moved Fertility In The News to the weekly newsletter in order to keep the podcast more evergreen. If you want to sign up go to nataliecrawfordmd.com/newsletter to sign up! Don't forget to ask your questions on Instagram for next week's For Fertility's Sake segment when you see the question box on Natalie's page @nataliecrawfordmd. You can also ask a question by calling in and leaving a voicemail. Call 657–229–3672 and ask your fertility question today!      Thanks to our amazing sponsors! Check out these deals just for you: Factor- Head to factormeals.com/aaw50 and use code aaw50 to get 50% off. Apostrophe- Get your first visit for only five dollars at Apostrophe.com/AAW or use the code AAW at checkout. Athena Club-Go to athenaclub.com and use code AAW for 25% off your first order. Mosie Baby -Go to try.mosiebaby.com/AsAWoman and use code ASAWOMAN for 15% off your order at checkout LMNT-Go to DrinkLMNT.com/AAW to receive a free sample pack with any purchase AG1-Go to drinkAG1.com/asawoman and get a FREE 1-year supply of Vitamin D AND 5 Free AG1 Travel Packs with your first purchase. Quince- Go to Quince.com/aaw for free shipping on your order and 365-day returns If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every Sunday. Plus, be sure to follow along on Instagram @nataliecrawfordmd, check out Natalie's YouTube channel Natalie Crawford MD, and if you're interested in becoming a patient, check out Fora Fertility. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Vuelta a España is just around the corner, but before the focus switches to the final Grand Tour of the season there are plenty of other big talking points in the pro peloton. These are RadioCycling's latest headline stories...We start on familiar ground, with a look at the latest developments and rumours involving the Ineos Grenadiers, Soudal-QuickStep and, it almost goes without saying, Remco Evenepoel. What began as a quest by the British team to sign the Belgian team's leader is turning into something quite different and much more substantial. There's talk of a merger of the two squads, a move that could suit the key players on both sides and could, if confirmed, result in two billionaires joining forces in what would be the most super of teams. It's been a bad week for doping cases. On the heels of the Richard Freeman verdict, Belgian cyclo-cross star Toon Aerts has copped a two-year ban after testing positive for Letrozole, a verdict which doesn't bode well for his compatriot Shari Bossuyt, who now appears to be facing the same fate for the same product. Meanwhile, Jumbo-Visma GC prospect Michel Hessman has delivered a positive test for an unknown diuretic. We examine these cases and discuss where they leave the riders involved, their teams and the sport as a whole.Lidl-Trek have been arguably the biggest movers in the transfer market in August, and the raft of talent highlights that they've definitely not been shopping in the cycling equivalent of the middle aisle in your local Lidl. We hear from the team's head of performance, Josu Larrazabal, who reveals the thinking behind the arrival of seven highly experienced racers including GC leader Tao Geoghegan Hart and top sprinter Jonathan Milan, and of the team's hopes of becoming stage racing big-hitters. Finally, our super sleuth, Chris Marshall-Bell, is already thinking eight years down the line, to the 2031 Super Worlds. The UCI has said five countries from three continents are interested, and our journalistic bloodhound believes he's identified three of them, with the ruling body's home country admitting that it's very much in the running. Support the show

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.16.549229v1?rss=1 Authors: Onaolapo, O. J., Aworinde, O. O., Olofinnade, A. T., Onaolapo, A. Y. Abstract: Hyperandrogenism is the excessive production of androgenic hormones resulting in infertility in a number of women. While letrozole and clomiphene citrate have been used to increase chances of achieving pregnancy, their effects on the brain has been scarcely studied. This study examined the effects of clomiphene and letrozole alone or in combination on neurobehavioural and neurochemical changes in female rats exposed to testosterone. Weaned rats were assigned into eight groups of ten each. Animals were grouped as normal control administered vehicle (normal saline) orally at 10 ml/kg or subcutaneously at 2 ml/kg, three groups administered clomiphene (CLOM) at 100 microgramme/kg, letrozole (LETR) at 5 mg/kg and or a combination of clomiphene and letrozole (CLOM/LETR) orally and saline subcutaneously. There were also four groups Testosterone (Test), Test/CLOM, Test/LETR or Test/CLOM+LETR administered testosterone enantate subcutaneously at 1 mg/100 g. Testosterone or saline was administered from day 1-35, while beginning on day 36, clomiphene, letrozole or saline was administered daily for 10 days. At the end of the dosing period, animals were exposed to different behavioural paradigms. After the behavioural tests, animals were sacrificed, the cerebral cortex was homogenised for the assessment of biochemical assays. The result showed an increase in body weight, food intake, locomotor activity, rearing and self grooming with CLOM, LETR and CLOM/LETR in all treated groups. Decreased spatial working memory and anxiolysis was observed with letrozole and/or clomiphene. Increased oxidative stress, decreased total antioxidant capacity, altered inflammatory cytokines and brain neurotransmitter were observed with letrozole and /or clomiphene. In conclusion, the administration of clomiphene and/or letrozole was associated with significant alterations in brain function, oxidative stress, inflammatory markers and brain neurotransmitter levels. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr. Natalie Crawford answers the voicemails you called in. Questions Answered: When to remove IUD? How to choose a long term storage facility for frozen eggs? Does having one miscarriage mean you have a higher chance of having another? Conventional IVF vs ICSI for a lesbian couple with no known fertility issues? Clomid or Letrozole for medicated IUI for unexplained infertility? Is it normal to have a positive pregnancy test one evening and a negative test the next morning? I have a blocked tube and have had three unsuccessful IUIs. Should I see further testing? How important is it to take antibiotics when getting an HSG? Don't forget to ask your questions on Instagram for next week's For Fertility's Sake segment when you see the question box on Natalie's page @nataliecrawfordmd. You can also ask a question by calling in and leaving a voicemail. Call 657–229–3672 and ask your fertility question today!      Thanks to our amazing sponsors! Check out these deals just for you: Apostrophe- Get your first visit for only five dollars at Apostrophe.com/AAW or use the code AAW at checkout. Strategy- Get 15% off your first purchase by using the code AAW at checkout when you go to strategyskincare.com or go to https://strategyskincare.com/discount/AAW BetterHelp - Go to BetterHelp.com/AAW today to get 10% off your first month. Liquid IV- Go to liquidiv.com and use code AAW at checkout for 20% off Nutrisense- Visit nutrisense.io and use code AAW to save $30 and get 1 month of free dietitian support. If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every Sunday. Plus, be sure to follow along on Instagram @nataliecrawfordmd, check out Natalie's YouTube channel Natalie Crawford MD, and if you're interested in becoming a patient, check out Fora Fertility. Learn more about your ad choices. Visit megaphone.fm/adchoices

Our latest episode kicks off with an exclusive interview with Vuelta a España director Javier Guillén, who tells us that there's absolutely no prospect of the Vuelta swapping dates with the Giro d'Italia, a move that many were pushing for as a possible solution to the bad weather that perennially affects Italy's Grand Tour. "No, no and no!" declares Guillén. Looking ahead to this year's Vuelta, now just 10 weeks away, Guillén says all the big names will be welcome and discussions are under way to tempt the likes of defending champion Remco Evenepoel and three-time winner Primož Roglič back to Spain in late AugustAfter being made "provisionally non-active" by her Canyon//SRAM team following a positive test for the banned product Letrozole, Belgian world track champion Shari Bossuyt has given her side of the story in a press conference. In it, Bossuyt said her situation was like being put "in prison for murder when you didn't commit murder." Everyone's gone Derek Gee-crazy following his stand-out performance at the Giro d'Italia, and that includes his Israel-Premier Tech team, who've signed him to a contract that runs to the end of 2028. Team director Steve Bauer tells us about the qualities that make Gee so special and why the Canadian sensation could become a power in the Classics as well as the Grand Tours.Bora-Hansgrohe director Rolf Aldag tells why and how the German WorldTour team are set to change tack for the Grand Tours and challenge the big-hitting teams that tend to dominate the GC battle in these marquee races. As part of that strategy, he reveals that the upcoming Tour de France will probably be the last that they'll go into with a sprinter as well as a GC leader.Support the show

Dr. Natalie Crawford answers the voicemails you called in. Questions Answered: Is it just as difficult to get pregnant the first time as it is the second time with PCOS? What is the best way to track ovulation if you have PCOS? Based on my cervical mucus, I seem to be ovulating later in my cycle. Is there a good way to track ovulation in this case to avoid being unsure of my fertile window. I got off birth control over 3 months ago and haven't gotten my period back. What next? What are your thoughts in viagra being part of an IVF protocol? What are the next steps after 3 failed transfers? I'm starting Letrozole for the first time. Are there any tips to increase success? Learn more about your ad choices. Visit megaphone.fm/adchoices

New study on combining low-dose dexamethasone with letrozole in women with PCOS who failed to ovulate with letrozole alone. This study looked at ovulation, pregnancy, and live birth rates and took place at the Mayo Clinic from 2019 to 2022. ResourcesBarbieri RL and Ehrmann DA. Diagnosis of polycystic ovary syndrome in adults. In: Post T, ed. UpToDate. Waltham, Mass.: UpToDate; 2034. www.uptodate.com. Accessed May 20, 2023.Legro RS, Brzyski RG, Diamond MP, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome [published correction appears in N Engl J Med. 2014 Oct 9;317(15):1465]. N Engl J Med. 2014;371(2):119-129. doi:10.1056/NEJMoa1313517Neblett MF 2nd, Baumgarten SC, Babayev SN, Shenoy CC. Ovulation induction with letrozole and dexamethasone in infertile patients with letrozole-resistant polycystic ovary syndrome [published online ahead of print, 2023 May 2]. J Assist Reprod Genet. 2023;10.1007/s10815-023-02817-9. doi:10.1007/s10815-023-02817-9

Today, we explore the future advancements of in vitro fertilization (IVF) by talking with the most senior reproductive endocrinologist in Canada, Dr. Al Yuzpe. Sometimes you need to understand the beginning of fertility treatments and how far we've come in the past 50 years and why there's so much more promise and hope in the coming years. A groundbreaking reproductive technology that has helped countless couples achieve their dreams of parenthood. Dr. Albert Yuzpe, a renowned doctor in the field of reproductive medicine and infertility, shares with us his journey in helping develop Clomiphene, a widely used and successful drug for inducing ovulation in women, and one of the early adopters of laparoscopic surgery in Canada. Finally, he expresses his love for the field of reproductive medicine and his excitement for its future. How technology and Artificial Intelligence has helped improve the process of IVF and the many upcoming upgrades for pregnancy procedures. Tune in to gain valuable insights on reproductive medicine and infertility from a seasoned expert in the field. Key Topics: ●      Dr. Al's background and achievements in reproductive medicine and infertility ●      Development of Clomiphene and its success in inducing ovulation in women ●      Experimentation with Letrozole, FSH, and HCG for treating infertility ●      Common side effects and risks associated with Clomiphene ●      Reproductive medicine and its future impact on growing families.     About Al Yuzpe: Dr. Yuzpe has been the recipient of numerous awards, including the Canadian Fertility and Andrology Society Award of Excellence in Reproductive Medicine, the Society of Obstetricians and Gynecologists President's Award ("for his distinguished career in academic reproductive endocrinology and infertility and his dedication to women's health in Canada and abroad"), and the Royal College of Physicians and Surgeons Speaker's Award. Dr. Yuzpe is co-founder and co-director of Olive Fertility Centre. As Canada's most senior Reproductive Endocrinologist, he has been involved in IVF for the past 30 years and in the field of infertility for the past 43 years. He received his MD, M Sc. and completed his fellowship training in obstetrics and gynecology at Western University, London, Ontario. During his training, Dr. Yuzpe was a Fellow of the Medical Research Council of Canada for two years with his research focusing on the development and refinement of fertility-promoting drugs, including clomiphene and human gonadotropins. Dr. Yuzpe joined the Western University Faculty of Medicine, Department of Obstetrics and Gynecology, in 1970 and passed through the academic ranks to full professor. He retired from the university in June, 1995, and now holds the distinguished academic appointment of Emeritus Professor of Obstetrics and Gynecology. Dr. Yuzpe then went on to found the Genesis Fertility Centre in Vancouver, British Columbia.  He pioneered the development of the emergency contraceptive pill, which is often referred to as "The Yuzpe method." This method was recently listed by the Canadian Child and Youth Health Coalition as among the 10 Canadian discoveries with the greatest impact, or the greatest potential for impact, on health outcomes for children and youth in the last 100 years.   Where To Find Dr. Albert Yuzpe   -        Olive Fertility Centre -        https://www.olivefertility.com/your-olive-team/dr-al-yuzpe       How to connect to Lorne Brown online and in person (Vancouver, BC)   Acubalance.ca book virtual or in person conscious work sessions with Dr. Lorne Brown Lornebrown.com   Conscious hacks and tools to optimize your fertility by Dr. Lorne Brown: https://acubalance.ca/conscious-work/   Download a free copy of the Acubalance Fertility Diet & Recipes and a copy of the ebook 5 Ways to Maximize Your Chances of Getting Pregnant from Acubalance.ca     Connect with Lorne and the podcast on Instagram:   @acubalancewellnesscentre   @conscious_fertility_podcast   @lorne_brown_official       DISCLAIMER: By listening to this podcast, you agree not to use it as medical advice to treat any medical condition in either yourself or others. This podcast offers information to help the listener cooperate with physicians, mental health professionals or other healthcare providers in a mutual quest for optimal well-being. We advise listeners to carefully review and understand the ideas presented, and to consult your own physician for any medical issues that you may be having. Under no circumstances shall Acubalance, any guests or contributors to the Conscious Fertility podcast, or any employees, associates, or affiliates of Acubalance be responsible for damages arising from the use of the podcast.

In this episode, we discuss the repair of cystotomies along with the scope of general OB/GYN. Plus, COVID and maternal mortality updates. Then some new literature including an update on Clomiphene vs Letrozole and Azithromycin for vaginal birth. Finally, the best female eponym ever and the removal of Makena from the market. 

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Letrozole more efficacious than clomiphene for infertility treatment among individuals with polycystic ovarian syndrome '

Dr. Natalie Crawford explains how the uterus is formed and the different types of uterine birth defects including a transverse vaginal septum, bicornuate uterus, unicornuate uterus, uterine septums, and more. So often there are no warning signs until you reach infertility or are getting an evaluation. She also goes into detail about a uterine septum, which is the most common uterine birth defect, and the procedure to fix them. In this week's Fertility in the News, Natalie discusses celebrities sharing their experience with using a gestational carrier including Paris Hilton, Priyanka Chopra, and Kim Kardashian. She explains how this decision is not always easy for patients and how sharing about it makes others feel less alone. She also explains the difference between the terms surrogate and gestational carrier and why it's important to know the difference. Finally, Natalie answers your social media questions during her segment FFS—For Fertility's Sake. Why am I not ovulating on Letrozole or Clomid? Do people with diminished ovarian reserve always need donated eggs? What are the best tips for the embryo to implant during the two week wait- are avocados and pineapples a myth? How can antiphospholipid antibody syndrome be treated? Don't forget to ask your questions on Instagram for next week's For Fertility's Sake segment when you see the question box on Natalie's page @nataliecrawfordmd. You can also ask a question by calling in and leaving a voicemail. Call 657–229–3672 and ask your fertility question today!       If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every Sunday. Plus, be sure to follow along on Instagram @nataliecrawfordmd, check out Natalie's YouTube channel Natalie Crawford MD, and if you're interested in becoming a patient, check out Fora Fertility.  Learn more about your ad choices. Visit megaphone.fm/adchoices

For some people, Letrozole and Clomid doesn't make them ovulate. What do you do next? In today's podcast we discuss this. 

Take a sneak peak at this month's Fertility & Sterility! Topics this month include the impact of genetics lab on euploid and live birth rates (01:58), pregnancy & neonatal outcomes after long-term vitrification (09:44), risk of hypertensive disorders of pregnancy in donated-embryos pregnancies (18:08), diagnosing ectopic pregnancy using Bayes theorem (25:42), markers of ovarian reserve as predictors of future fertility (34:36) and letrozole-induced ovulation in women with PCOS and letrozole resistance (40:46). View the January 2023 issue of Fertility and Sterility: Volume 119, No 1 - https://www.fertstert.org/issue/S0015-0282(22)X0004-6  View Fertility and Sterility at https://www.fertstert.org/

Dr. Natalie Crawford discusses planning your family and when to have kids. She tells you her story of becoming a parent and what that looked like in medical training. Natalie also shares what she wishes she would've prioritized when it comes to health before trying to get pregnant.  In this week's Fertility In The News, Natalie responds to Ricki Lake's clip claiming the birth control pill causes early menopause and explains why this is “fake news.” She also goes over the variety of reasons someone may take the birth control pill. Finally, Natalie answers your social media questions during her segment FFS—For Fertility's Sake.What is your advice for recovering from a miscarriage, specifically a blighted ovum? How often do you see Ashermann's syndrome after a pregnancy ending in D&C? How do you deal with an azoospermia diagnosis? How many rounds of Letrozole should I do before moving on to a different treatment while TTC with PCOS? Do you use Clomid or Letrozole days 5-9 even if your periods are irregular? Don't forget to ask your questions on Instagram for next week's For Fertility's Sake segment when you see the question box on Natalie's page @nataliecrawfordmd. You can also ask a question by calling in and leaving a voicemail. Call 657–229–3672 and ask your fertility question today!       If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every Sunday. Plus, be sure to follow along on Instagram @nataliecrawfordmd, check out Natalie's YouTube channel Natalie Crawford MD, and if you're interested in becoming a patient, check out Fora Fertility.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Going through chemo and cancer treatment, you probably thought you were done with cancer once you run the bell.  Wrong. Bring on Tamoxifen therapy for 5 years, 10 years, or even indefinitely can mean you feel like a stranger in your body.   But here is the good news - there are steps you can take to get rid of these side effects.  For those on tamoxifen, you will want to listen to this episode because we are diving into the side effects of the drug and what you can do to be free from those side effects. 

Lynette talks about her many cycles on Letrozole after being diagnosed PCOS, multiple miscarriages and laparoscopy before commencing IVF with PGS. Lynette goes into depth about having a thin uterine lining and how she prepared for her latest FET. All the best Lynette! Thank you for sharing your story and all that you do on not.another.bad.egg. Interested in sharing your tale? Contact me via Instagram or email ivftalespodcast@outlook.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.01.514755v1?rss=1 Authors: Mamczarz, J. A., Lane, M., Merchenthaler, I. Abstract: Letrozole, an aromatase inhibitor (AI), is used as an adjuvant therapy in estrogen receptor-positive (ER+) breast cancer patients. Similar to other AIs, it induces many side effects, including impaired cognition. Despite its negative effect in humans, results from animal models are inconsistent and suggest that letrozole can either impair or improve cognition. Here we studied effects of letrozole on cognitive behavior of adult female BALB/c mice, a relevant animal model for breast cancer studies. Mice were continuously treated with once-a-day subcutaneous (s.c.) injections of letrozole (0.1 or 0.3 mg/kg/day) or vehicle and subjected to behavioral testing starting on day 21 after treatment initiation. During the treatments, vaginal smears were taken from the mice to evaluate estrous cyclicity. Both doses of letrozole suspended cyclicity and the smears showed that the mice were in constant metestrus. Exposure to letrozole did not significantly affect response to novelty measured as a locomotor activity in open field. However, repeated testing in open field (4 days x 15 min) revealed that letrozole 0.3 mg/kg facilitated locomotor habituation (a form of non-associative learning), significantly reducing locomotor activity on 3rd and 4th day of testing. These findings suggest that certain doses of letrozole may have positive effects on cognitive behavior. Training to find a hidden platform in the Morris water maze (15 days x 4 trials), however, indicated that letrozole 0.1 mg/kg-treated mice had significant learning impairment, as, throughout the training, they swam longer times than vehicle-treated mice to reach the hidden platform. Similarly, in a probe test performed 72 h after the last day of the training, letrozole 0.1 mg/kg-treated mice did not show preference for the training platform zones. These results indicate that cognitive impairments reported by women treated with letrozole can be captured in BALB/c mice treated with clinically relevant doses of the drug. Interestingly, most of the letrozole 0.1 mg/kg-treated mice were able to learn the new platform position in reversal training and performed similar to control mice in a reversal probe test. Results of the reversal test suggest that letrozole did not completely disrupt spatial navigation but rather delayed acquisition of spatial information. The current study shows that letrozole dose dependently modulates behavioral response and that its effects are task dependent. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Take a sneak peak at this month's Fertility & Sterility! Topics this month include the natural history of fibroids in pregnancy (1:54), semen quality in sons of subfertile couples (09:33), oocyte maturity ratio and live birth rate (18:41), pregnancy outcomes after frozen transfer using Letrozole (22:28), endometrial receptivity assay after failed transfer attempt (36:08), colorectal cancer risk after use of fertility drugs (45:08), and cesarean-section scar defects and abnormal uteirne bleeding (56:13). View Fertility and Sterility Volume 118 Issue 4 - https://www.fertstert.org/issue/S0015-0282(21)X0024-6 View Fertility and Sterility at https://www.fertstert.org/

In this episode of Kiwi Birth Tales I speak with Claud about the birth of her daughter Elodie.In the episode we cover: - PCOS- Nutrition and lifestyle with Sara @yourmonthly- Missed miscarriage- Letrozole- Fear about another pregnancy loss- Birth education - Changing midwife @ 30 weeks- Doula- Homebirth- Long pushing phase- Episiotomy- SCBU for infectionThanks so much for joining me Claud! You're a star.This episode is sponsored by Your Birth Project, the online Hypnobirthing course designed for ALL births, create YOUR best birth with Your Birth Project. 

In this episode I share my first experience with letrozole. I share all the side effect I felt throughout the entire cycle. Please note I am just here to share my experience and what my doctor shared with me on how it will help me personally. Every body is so different and reacts to medications differently. I hope this episode empowers you. Trigger Warning: Talk of suicide and depression. 

Join host Dr. Natalie Crawford as she reviews the basics of commonly used fertility medications to treat infertility - clomid and letrozole. These medications work similarly, but are different, and it is important for you to know why you might be prescribed one. Learn more about ovulation induction for FHA or PCOS, treatment for unexplained infertility, side effects and risks. In support of National Infertility Awareness Week please consider supporting Resolve www.resolve.org

Letrozole with estrogen, just before progesterone: a thoughtful study on frozen embryo transfer.

This weeks episode is all about Rachael and her story navigating infertility.Her story involves:Hashimotos ThyroiditisAnovulationReferred to FA after 6 months TTCLetrozole / clomipheneIVFFresh transferMedicated frozen transfer Losing weight to qualify for public fundingChemical pregnanciesNatural pregnancy Miscarriage We hope you enjoy!

In this week's episode, we'll discuss a recent FDA approval in germline BRCA-mutated, HER2-negative, high-risk early breast cancer. Then, we'll hear about the publication of final overall survival results from the MONALEESA-2 trial, which evaluated the efficacy of the addition of ribociclib to letrozole in the first-line treatment of postmenopausal women with hormone receptor–positive, HER2-negative advanced breast cancer.Coverage of stories discussed this week on ascopost.com:FDA Approves Olaparib for Adjuvant Treatment of High-Risk Early Breast CancerFinal Overall Survival Analysis of MONALEESA-2: Addition of Ribociclib to Letrozole in Postmenopausal Women With HR-Positive, HER2-Negative Advanced Breast CancerTo listen to more podcasts from ASCO, visit asco.org/podcasts.

After Carol told her husband, “Maybe people would be better off without me here on earth,” she got help. When she grew bitter towards pregnant women, and didn't want to even be around them, God nudged her to serve them. This is her story. If you're having thoughts of suicide, hope is a phone call away. In the USA: call the National Suicide Prevention Hotline at 1–800–273–8255. In Canada: call the Canadian Association for Suicide Prevention at 1–833–456–4566. (In Québec, call 1–866–277–3553.) In Australia: call Lifeline at 13 11 14. In the UK: you can call the NHS 111 service. Also in the UK, you can call Samaritans 24/7/365 at 116 123. You can also text SHOUT to 85258. Free Sarah's Laughter Devotional Reading Plan on Bible.com The Hope Narrative is coming to Jesup, Georgia on April 30, 2022! Visit hopenarrative.org to register. For more about Sarah's Laughter, please visit our website at sarahs-laughter.com. You can follow us on social media linked here: Sarah's Laughter on Facebook & Instagram, and @sarahs_laughter on Twitter. Sarah's Laughter is a 501(c)(3) non-profit public charity. If you'd like to help support what we do, including this podcast, please visit sarahs-laughter.com/give. Thank you. Want to share your infertility story on this podcast? Email us at podcast@sarahs-laughter.com

This weeks update is a heavy one! Skip to 25 mins if you don't want to tune in, it covers: Jasmyn - follow up phone consult with FA about test results, potential surgery, struggling. Lydia - scheduling in IVF, cancelling trips, shift in the feeling of the two week wait. We had the pleasure of catching up with Nadia about her trying to conceive journey so far. Her story covers:Coming off the pill and having serious side effects from itUnexplained sporadic extreme pain for years Advocating for yourselfMisdiagnosed with mittelschmerzPreparing for pregnancy. Trying to ensure pregnancy will be possibleDiagnosed with adenomyosisHCG testMedicated cycles using LetrozoleSelf referred to Fertility AssociatesDiagnosed with stage 3 endometriosis Lap surgeryLooking at IVF as the next stepEmotional toll of TTCEndometrioses website: https://nzendo.org.nz/esig/

We take a dive into the two popular ovarian stimulation medications, and how they work and who they are useful for. 

In episode #065, Tahnee Milner shares her story of personal loss. In 18 months, she has experienced four miscarriages. Tahnee's first pregnancy was considered a chemical pregnancy, and karyotype testing determined her second and third losses were related to chromosome abnormalities. Her fourth pregnancy ended in a blighted ovum. Tahnee shares advice on advocating for yourself, pushing for answers, and finding a practitioner who will listen to you. We also discuss the impact of miscarriage on a relationship, as well as the importance of taking time to heal. Tahnee encourages women to reach out to others, and to break the stigma. It should be okay to reveal your pregnancy early, and to share your experience with miscarriage. Your babies matter, and they should be celebrated. Topics Discussed: genetic testing, karyotype testing, chemical pregnancy, missed miscarriage, dilation and curettage (D & C), Letrozole, Trisomy 13, chromosome abnormalities, blighted ovum, misoprostol, miscarriage during lockdown, miscarriage and relationships CONNECT WITH TAHNEE- INSTAGRAM https://www.instagram.com/pregnancy_to_loss MISCARRIAGE HOPE DESK RESOURCES- Miscarriage Hope Desk aims to help women struggling miscarriage, pregnancy loss and recurrent miscarriages (RPL), by providing the following resources- - Library of Articles, found here- https://miscarriagehopedesk.com/library/understanding-why/ - Instagram Community- https://instagram.com/miscarriagehopedesk - Facebook Community- https://www.facebook.com/groups/1617075958466247/ - Free Miscarriage Lab Checklist- https://miscarriagehopedesk.com/labs - Free Weekly Newsletter- http://miscarriagehopedesk.com/newsletter FREE MEAL PLANS Do you need help getting healthy, tasty meals on the table? Check out our sponsor Prep Dish, PrepDish.com/mhd to get 2 weeks FREE! SHOW NOTES- https://miscarriagehopedesk.com/podcast/ Get a FREE Miscarriage Lab Testing Checklist- MiscarriageHopeDesk.com/labs

Today we discuss Amy's raw and emotional journey thus far. Amy goes into detail about her unexplained infertility struggles, IVF experience, plus some set backs along the way. She also shares with us where she is currently at on her journey. LINKS: Acupuncture - Awaken Acupuncture Bulimba | Kate Zouev Infertility Specialist Brisbane - Dr Scott Salisbury Gynaecologist - Dr Glenda McLaren Bulk Billing IVF Clinic - First Step Fertility Jump over to our Instagram page @infertilityandbeyond_ and show us some love!! & If you enjoyed this podcast don't forget to subscribe and leave us a glowing review!

Today's episode is the first in this year's summer replay series! Following up from yesterday's episode about IVF treatments, today's episode takes a deep dive into artificial reproductive technology (ART), more specifically IUI (intrauterine insemination), and the common drugs used (clomid/femara) as well as IVF success statistics. Today's episode is sponsored by Tempdrop! Tempdrop gives you everything you need to effortlessly track your fertility. Wear the Tempdrop sensor  while you sleep  for accurate basal body temperature readings without the stress of early morning wake ups. Tempdrop's accompanying app enables you to chart an array of symptoms alongside your BBT, including cervical mucus and OPKs. Combine these fertility signs all in one place to identify your fertile window and confirm ovulation. Whether you are trying to conceive, are avoiding pregnancy or want to chart for health reasons, Tempdrop makes fertility awareness accessible to all women - even if you don't have regular cycles or sleeping patterns. Identify your fertility window, in real time with Tempdrop. Follow this link to buy now!  And use code coupon code: FERTILITYFRIDAY at checkout for a 10% discount when your order! Topics discussed in today's episode: How effective is IUI? What is the difference between the pregnancy rate and the live birth rate? How to dissect “success” rates for IUI How do IUI success rates vary with age? What is the cumulative success rate of IUI and how does it differ from the success rate of an individual round? Does having more rounds of IUI increase your chances of conceiving? What are the side effects of Clomid? How do Clomid impact cervical mucus and your endometrial lining? Why up to 25% of women are resistant to Clomid What is Letrozole and how does it compare to Clomid for IUI? How do the pregnancy and miscarriage rates differ in women who use Clomid versus Letrozole? Why it's important to be critical of research studies Connect with Lisa: You can connect with Lisa on the Fertility Friday Website, and on Facebook and Twitter. Resources mentioned: FFP 138 | Post-Pill Amenorrhea | Why It Took 4 Years For Her Period To Come Back | Andrea Petrus FFP 141 | Surviving Hypothalamic Amenorrhea | Getting Your Period Back Without Fertility Drugs | Nicola Rinaldi FFP 109 | The Reality of Aging & Fertility | IVF & Assisted Reproductive Technology | The Future of Fertility Treatments | Dr. Marjorie Dixon FFP 127 | What Does a Normal Period Look Like? | How Much Am I Supposed To Bleed During My Period? | Lisa | Fertility Friday http://fertilityfriday.com/fertilityawareness http://fertilityfriday.com/pcos/ FFP 149 | The Truth About Ovulation Predictor Kits (OPKs) | Lisa | Fertility Friday Research Studies: Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate Extended letrozole regimen versus clomiphene citrate for superovulation in patients with unexplained infertility undergoing intrauterine insemination: a randomized controlled trial A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation Success Rate of Inseminations Dependent on Maternal Age? An Analysis of 4246 Insemination Cycles   Join the community! Find us in the Fertility Friday Facebook Group. Subscribe to the Fertility Friday Podcast in Apple Podcasts! Music Credit: Intro/Outro music Produced by J-Gantic A Special Thank You to Our Show Sponsors: Tempdrop This episode is sponsored by Tempdrop! Tempdrop gives you everything you need to effortlessly track your fertility. Click here to learn more now! Fertility Friday | Fertility Awareness Programs This episode is sponsored by my Fertility Awareness Programs! Master Fertility Awareness and take a deep dive into your cycles and how they relate to your overall health! Click here to apply now! The Fertility Awareness Charting Workbook This episode is sponsored by my new book the Fertility Awareness Mastery Charting. Click here to buy now.

In this episode I interview Nerique about her missed miscarriage. It was an experience that completely blindsided her but thanks to overwhelming support from online groups, she navigated her loss and started planning her next baby. A long cycle and painful periods prompted her to see a fertility specialist who discovered that scar tissue from her D+C had caused a blockage in her cervix. Once that was rectified, Nerique started taking medication to stimulate ovulation and she fell pregnant two months later. She chose midwifery group practice for her pregnancy care and had an incredibly positive induction experience followed by a smooth and swift vaginal birth.

In this episode I talk with Lisa who is 8 years into her journey to create her family.Lisa was originally diagnosed with PCOS at 18, which has evolved into hypothalamic-pituatary-ovarian (HPO) axis disorder.After getting married Lis and her husband headed straight to a fertility clinic and started on Letrozole treatment.  This was followed by two cycles of IUI and then they moved onto IVF.With no eggs collected from her first two cycles of IVF, they moved to a different protocol (IVM) which was also unsuccessful.Lisa developed Ovarian Hyperstimulation Syndrome and became very unwell and hospitalised following a double trigger cycle.It wasn't until her 7th embryo transfer and approximately 5 years into the journey that she became pregnant with her son Otis.Lisa believes strongly in strengthening her resilience and good self care to help her through these years of treatment.Following having their son, they contintued treatment to try for a second child.  One cycle was cancelled as Lisa had developed shingels and a very difficult time came when she became pregnant again but sadly had a miscarriage.Lisa npow puts any spare energy she has into charity work for Fertility Funding Charitable Trust to help others access fertility treatment.After eight years and 13 embryo transfers, Lisa and her husband continue with treatment.  They remain positive and hopeful that their second child will come.Follow Janine on instagramJanine's websiteFertility funding charitable trustDr SherFertility associatesMotherwell (Loula George)Podcast music created by Alan Meharry and Stu Fox

Dr. Heather Seay is a doctor of acupuncture and Chinese medicine who has been in practice for 12 years. She is also a fellow of the American Board of Oriental Reproductive Medicine. In her practice at Eastern Bench Holistic Healthcare in Salt Lake City, she commonly works with women who have fertility issues. As more positive research about the benefits of acupuncture becomes available, more traditional doctors are integrating it into treatments for those with PCOS. Listen in as Dr. Seay and I discuss: - What is Chinese medicine and how does it differ from Western medicine? - Benefits of acupuncture for fertility and PCOS - How to approach acupuncture with primary care or OB GYN doctors - Is it safe to practice acupuncture when using Clomid or Letrozole? - Possible treatment options for hair loss & weight loss

Letrozole is an aromatase inhibitor that acts as an antineoplastic agent. The brand name for letrozole is Femara. The main indication is for hormone receptor positive breast cancer in women after menopause. If treating early breast cancer letrozole is used after a 5 year course of tamoxifen. If treating advanced breast cancer letrozole follows antiestrogen therapy. There are many off label uses of letrozole such as the many variations of breast cancer along with treating infertility due to polycystic ovary syndrome (PCOS) through ovulation stimulation. Dosing is straight forward at 2.5 mg po qd with for 5 years (in early breast cancer treatment) or 2.5-7.5 mg po qd for 5 days starting on day 3, 4, or 5 following menses or progestin induced bleed. A patient consideration of note is a decrease in bone mineral density (BMD) has been seen 2 years after usage in patients using letrozole compared to patients not on letrozole. The most common side effects seen are hot flashes, headache, hypercholesterolemia, and weight gain. Common monitoring parameters are BMD, pregnancy, cholesterol, and adherence. Go to DrugCardsDaily.com for my episode show notes which will contain a drug summary, quiz, and a link to FREE drug card sheets. SUBSCRIBE on Spotify or Apple Podcasts or search for us on your favorite place to listen to podcasts. I will go over the Top 100-200 Drugs as well as throwing in some recently released drugs that peak my interest. Also, if you'd like to say hello, suggest a drug, or leave any constructive feedback on the show I'd really appreciate it! Leave a voice message at anchor.fm/drugcardsdaily or message us through twitter @drugcardsdaily --- Send in a voice message: https://anchor.fm/drugcardsdaily/message

Visit the PCOS & FERTILITY with Dr Jon Havelock podcast webpage. In this interview, Dr Havelock and myself discuss PCOS, its characteristics, proper diagnosis, and effective treatment with letrozole, metformin, IVF, diet, exercise, supplements & acupuncture. We also spend time discussing the larger metabolic/diabetic and cancer risks associated with PCOS.  Related Articles; >> ACUPUNCTURE ALTERS SUGAR METABOLISM AND GENE EXPRESSION IN PCOS PATIENTS >> HOW CASTOR OIL CAN HELP WITH PCOS >> ONE WOMAN'S JOURNEY THROUGH PCOS >> HOW ACUPUNCTURE AND CHINESE MEDICINE CAN HELP PCOS >> YES YOU CAN TREAT PCOS NATURALLY

We have spoken about Polycystic Ovarian Syndrome (PCOS) on the podcast numerous times in the past so make sure you scroll down to find link to previous episodes. Kate is an expert on the topic, working with women on a daily basis to support them with their diagnosis and in this episode, we've shared a previous conversation we had with Professor Adam Balen discussing the latest PCOS guidelines. Professor Adam Balen is a full-time National Health Service consultant and Lead Clinician at Leeds Fertility, one of the largest assisted conception units in the UK. His special interests include all aspects of PCOS, Assisted Conception, Paediatric & Adolescent Gynaecology and Disorders of Sexual Development. In this conversation, you hear snippets of ahttps://www.thefertilitypodcast.com/pcosguidelines/ ( previous episode) whereAdam explains what the symptoms of PCOS are, including being over or under weight and how to maintain the condition with lifestyle changes. He also talks indepth about the use of Letrozole over Clomofin, or Clomid are most people know it. At the time of our chat, people were still needing to change their mindset regarding prescribing Letrozole, and Adam had written papers for the RCOG to support this further. Kate said she is still seeing a mix of what people are being prescribed and explained how in the UK, heath trust policies can dictate what drugs are prescribed. However, Kate advises if you are on Clomid and not responding after two rounds to go back and ask if you can go back and try Letrozole. We discuss the link between Letrozole and Ovarian hyperstimulation syndrome (OHSS) as well as there being a lower risk of multiple pregnancy and also we discuss the frequency of scans people should expect when they are on these ovulation stimulation drugs We also highlighted the problem with home ovulation kits. When it comes to the common issues people are still coming up against Adam explains how women are still being told they won't get pregnant with ovulation issues or that they are overweight because you have PCOS and you can't do anything about it. Which isn't the case. Also the fact that a lot of women with PCOS end up having IVF when they don't need it which is why we want to ensure you know where to get more support. We also discuss howOvarian diathermy or Ovarian drilling which in vary rare cases is an operation used to stimulate ovulation. When it comes to top tips you can take away to manage your PCOS, Kate's top 3 tips are: Changing your diet to low refined carbs/sugar. Tracking your cycle tracking Become your own PCOS advocate Kate has written numerous blog post about PCOS. This one discusses https://yourfertilityjourney.com/pcos-cant-be-cured-but-it-absolutely-can-be-controlled/ (how whilst it can't be cured it can be controlled. ) You can also read about https://yourfertilityjourney.com/pcos-worst-enemy-heres-fight-back/ (fighting back against PCOS here ) and Kate also has a https://yourfertilityjourney.com/product/pcos-journal/ (brilliant journal you can use ) Have a listen to previous PCOS podcasts we have shared - this one with https://www.thefertilitypodcast.com/diva/ (PCOS Diva Amy Medling ) and this one https://www.thefertilitypodcast.com/kym/ (with Kym Campbell ) both amazing women who have overcome their PCOS and had successful pregnancies and now work to support women further with lifestyle changes. SOCIALS: See https://acast.com/privacy (acast.com/privacy) for privacy and opt-out information.

Kristin had a very long journey down the infertility and loss road. Clomid, Letrozole, IUI, change of doctor, a multitude of test, IVF, and losses all along the way. When she got to IVF she said I'm scared about injecting all this into my body. What is it going to do to me? Is it going to work? Is it going to work for me? The unknown made me super emotional about injecting all those hormones in my body. It was so hard to watch all my close friends get pregnant and none of them had trouble. I withdrew from them because I felt like it was always in my face. It was so hard to see pregnancy announcements and seeing the birth of their babies because I wanted that so badly. The hardest was my younger brother and his wife. I was angry and I felt guilty for feeling like that. When you have had multiple losses, it is easier to feel like giving up because you just do not want to go through it again. Kristin is 18 weeks pregnant at the time of this recording. She said every thing is going well but she is still very scared. Kristin's words of advice and encouragement: I want to encourage anyone that has struggled with infertility or has had loss to not lose hope. Be an advocate for yourself, make sure you are doing research. There are test that can be run to identify things that you might be struggling with. Stress is a big factor and this time I let go. Let go and Let God. Keep your mind busy with things if you are struggling. Find activities that are positive and uplifting, walks, yoga, coloring, anything that brings you joy to get your mind off of it because it is all consuming and that can stress you out and that does not help anything. Stay positive. God has different plans for everyone. Connect with me: EMAIL teresa.womenconnect2019@gmail.com Facebook https://www.facebook.com/.womenconnectsupport/. Phone # 1-618-560-8484

In this episode of Food, Freedom, and Fertility, Caitlin & Sophia take a different approach and independently choose two different topics in the world of fertility and PCOS along with their associated studies to dissect important topics in the world of women’s health so listeners can gather the data presented and understand the theories within their own frame of reference. The studies chosen by Caitlin and Sophia focus on Vitex, Letrozole, and Clomind.    Sophia started the conversation discussing a study involving Vitex, otherwise known as Chasteberry. Vitex is a supplement recommended for luteal phase to help with hyper prolactin anemia, which happens when your body’s body's makes too much prolactin. Most women notice this as a common reason for the luteal phase to be shorter than average with a menstrual cycle including heavy periods with intense pain and cramping. The study chosen aimed to prove whether or not Vitex could reduce elevated prolactin resulting in the luteal phase lengthening and progesterone levels normalizing.  As Sophia continues to dissect the study, both weigh in on their known benefits and drawbacks of Vitex through their own experiences and exposure to the herbal supplement.    Caitlin’s chosen study involved the debate on Letrozole versus Clomid. Clomid is a fertility drug which blocks your brain’s estrogen receptors and makes your body think its estrogen levels are low which results in the making of more follicle stimulating the FH hormone, the hormone responsible for triggering your body to grow follicles to size. Letrozole is a newer drug that also changes how your body makes estrogen but instead of using brain receptors, it triggers the enzyme responsible for turning testosterone into estrogen to stop. This causes your body to produce more estrogen in other ways to compensate for the lower levels in the body. Both are known to induce ovulating, which proves to be helpful for the population living with PCOS.  The Clomid study chosen focused on that group of women within the United States. In the study a somewhat shocking statistic rate is shared from Caitlin to make listeners aware of the drug’s success rate while also detailing the processes and side effects the body can withstand when taking Clomid.  The study related to Letrozole, identifies some advantages over Clomid while sounding similar processes within the body. Both studies show staggering statistics including strong differences of each drug, which Caitlin aims to share openly and critically with listeners who hold stake in the wellness of their fertility process.   When discussing these studies, Caitlin and Sophia aim to quantify the scientific descriptions into relatable context for listen to digest within their own world of fertility.  While focusing on discussion rather than hard persuasion, Caitlin and Sophia hope to give listeners helpful information so steps can be taken alongside a medical care professional in an effort to reach a healthy fertility process.

If you Friend have an auto-immune disease or maybe someone you, this episode is for you!Imagine being a survivor of two autoimmune diseases-fibromyalgia and lupus. Surprisingly, Ashley's autoimmune diseases are not the culprits for her infertile diagnosis; PCOS (polycystic ovarian syndrome) is to blame, as well as male-factor.Ashley's TTC journey to motherhood began at a time when she had her life perfectly planned and executed. Finished grad school, married to the love of her life, and a place to call home. But that quickly changed after stopping birth control to try and conceive naturally. Within a matter of months, Ashley was diagnosed with PCOS. She had been on birth control for over 15 years; which she believes helped to mask the symptoms of the condition.After more tests, Ashley's doctor concluded that her body did not ovulate on its own and she would need reproductive assistance to become pregnant. After four medicated cycles with a fertility medication called Letrozole, Ashley and her husband finally had their BFP (big fat positive). But sadly the results of the second beta test concluded that Ashley was going to miscarry. After her miscarriage, a cyst was found on Ashley's ovary which forced her and hubby to take a month off from fertility treatment.Join us Friend as we Get Connected & Stay Plugged In to Heal Together!Follow Ashley on Instagram @rage_against_infertilityTEXT Monique @ 443-569-0642 with your feedback, comments, or questionsFollow IAM on Instagram!Subscribe and watch on the YouTube Channel here!Affiliate Links:Natalist:The Prenatal Multi contains doctor-recommended ingredients to prepare your body for pregnancy and promote the healthy development of your future baby.‡1 month supply: 60 vegan capsulesFormulated with MTHF folate Contains no yeast, wheat, gluten, soy protein, dairy, corn, sodium, sugar, starch, artificial coloring, preservatives, or flavoringPair with our Omega DHA for a complete routinePregnancy Tests!If you enjoy this podcast, please consider leaving a review on Apple iTunes so that we can continue to grow and spread the message of Connecting And Healing Together.Support the show (http://PayPal.me/infertilityandmepod)

“You need to be open to a myriad of curve balls that may come your way (in this fertility journey). It starts with self-love and loving your body. Try to stay positive and love your body.” -Marguerite Today's guest is Marguerite from Virgina. She is a lawyer, infertility warrior, and dog mom. She has been married for 9 years and have been TTC since the beginning. She was diagnosed with prolactinoma, endometriosis, and diminished ovarian reserve. She first tried NaPRO. They tried a timed and medicated intercourse with Letrozole but was unsuccessful. Marguerite also developed ovarian cysts as a side effect of Letrozole. She and her husband then tried IVF. She had 2 egg retrievals back to back. But they decided to postpone the fresh transfer due to her husband's diagnosis of COVID. They have frozen embryos that they will wait later in the year to transfer. I'm thrilled to have Marguerite on the podcast, sharing her journey to motherhood with us. If you enjoyed today's episode, subscribe to the Fertility Stories podcast and leave a review. Podcast freebie: 7 day fertility optimizing meal plan with recipes and grocery list. Click the link to download freebie: https://fertilityfundamentals.clickfunnels.com/optin1588646493313 --- Send in a voice message: https://anchor.fm/fertilitystories/message

Evolutionary radio presents another exciting podcast. Host Stevesmi is joined by co-host Rick . Totally raw and unfiltered, this time they talk about the anti-estrogen drug called Letrozole: 1. What is Letrozole 2. History 3. Avoiding mistakes 4. Best way to utilize it 5. Best ways to stack it 6. How to find it Letrozole article: https://www.evolutionary.org/letrozole-femara Discuss Letrozole here https://www.evolutionary.org/forums/anabolic-steroids-peds/letrozole-gyno-41128.html Follow Rick V on Instagram: https://www.BigRickRock.com

Fertility treatment options and plans are so confusing. We dive into some non-invasive fertility treatments and a few things that may be happening along an infertility journey. No matter where you are, this information can be helpful to know and understand, if not for yourself, but a friend. We close the ep with some inspiration that anyone can take with them to help stay positive. Next ep we will discuss packing your hospital bag! Let us know what you think on the insta page. 

https://steroidspodcast.com 0:00 When to Take Anti Estrogen (Arimidex, Exemestane, Letrozole) 1:50 When Testosterone Peaks in the blood after a Shot 4:40 How Long Testosterone Cycle takes to Kick In 5:55 Intensity at the Gym 7:30 Tempo and Rep Cadence for Muscle Gains 14:45 You Won’t Meet you goals if you behave as if Steroids are some kind of shortcut 15:30 1000mg Testosterone 600mg Deca 300mg Equipoise 350mg Anavar 350mg Dbol Cycle 18:30 When to Add Tren into a Steroid Cycle – Tolerable Trenbolone Dosages 20:50 When using Trenbolone your Dick is Not as Big 23:00 High Dosages of Trenbolone 25:35 Pharmaceutical Grade Testosterone Deca Durabolin and Primobolan being Faked 27:00 Details of Pharmaceutical Grade Steroids that make them superior 28:00 cRP C-Reactive Protein Levels Inflammation increased because of Synthetic Oils being used to make UGL Gear 29:00 Steroids Available in Pharmacies in Vietnam 30:00 Favorite Pharmaceutical Grade Brands of Steroids 31:00 Details of Authentic Bayer Primobolan – How to Tell Real or Fake Counterfeit 32:05 Reason why Pharmaceutical Grade Injectable Steroids Oils are so Much Thicker than Underground Lab 34:00 Trenbolone Cortisol 35:40 Testosterone to Trenbolone Ratio 39:05 How I Run Anadrol Cycle 40:50 In Depth Anadrol Common Use and Effects 42:35 Anadrol Side Effects – Some Bad Experiences 44:12 Can You Mix HCG and Testosterone or Other Steroids in the Same Syringe 46:25 Question Regarding Genetics and Work Ethic Versus Performance Enhancing Drug Use 48:35 Sex Drive Problems on Steroid Cycle and Troubleshooting 51:50 Cosmetic Effects of Steroids Different Testosterone Esters 53:37 Combining Deca and Testosterone or other Steroids in the Same Syringe 54:40 my 700mg Primobolan 700mg Testosterone Propionate per Week Injection Protocol 55:35 How I Reconstitute and Inject HGH – What is the Difference Between Growth Hormone Vials and Pens 57:50 Growth Hormone Pens like Genotropin and Norditropin are the peak of current science in HGH Technology and Preservation 59:50 My Protocol for Subcutaneous HGH Injections 1:05:15 Subcutaneous vs. Intramuscular Growth Hormone Injections 1:07:03 Body Hair and Steroids Use

The Steroids Podcast Episode 9 https://steroidspodcast.com 00:00 1000mg testosterone + 300mg tren ace vs. 1000mg testosterone + 1000mg primobolan + 4IU norditropin 04:40 Letrozole vs Aromasin Exemestane vs Arimidex Anastrozole 06:00 Testosterone Dosage vs Anti Estrogen Dosage 08:25 Exemestane is the best anti estrogen tablet + how exemestane works to stop conversion of testosterone to estrogen 10:05 Aromatase Inhibitor BroScience 13:50 BroScience has big value 14:28 Compare SARMS cycle to Test and Trenbolone Cycle 15:27 Juiced up SARM monsters lmao 16:14 How I sometimes use SARMS with high testosterone instead of Oral Steroids for health reasons. SARMS do not require breakdown in the liver + SARMs Toxicity 19:00 I Like S23 better than LGD-4033 20:25 Ran out of Arimidex has Gyno symptoms and hard lump behind nipple for 3 weeks, Is it possible to Shrink Gyno Bitch Tits once you have a lump? 21:20 How to shrink Gyno Bitch tits Protocol (not medical advice) + Tamoxifen vs Raloxifene 25:20 Deca and Tren Gyno 26:40 What are Dopamine Agonists like Cabergoline and Pramipexole 29:22 T3 Thyroid Hormone Effects - Heart Palpitations and Pounding Heart Thyroid side effects. Muscle Weakness, Overheating, and Loss of breath from T3 thyroid hormone 32:00 T4 Thyroid prohormone as a replacement for T3 cytomel + Thyroid Hormone Dosages used commonly by bodybuilders 33:55 Why people like to use thyroid hormones while dieting 36:41 Front Loading Long Acting Esters of Steroids to Start a Cycle 37:35 Steroid Cycle Kick in Time 40:20 Frontloaded my first week of my first steroid cycle first injection was 600mg testosterone enanthate in each ventroglute for 1200mg total 41:15 Oral Steroids Kick in Time 42:00 Using Steroids on a Budget to Get Huge 46:20 Thoughts on Jintropin Labeled with Russian Packaging 48:00 HGH: Jintropin vs Norditropin Experience 50:10 Norditropin is best Growth Hormone for Fat Loss 52:08 Androgen Receptor Desensitization + Myostatin 54:45 The Biggest Bodybuilders are on the biggest dosages of performance enhancing drugs for the longest periods of time 56:32 Testosterone Cruise Dosage to Maintain Muscle Gains from Cycle 57:50 Purpose of Cruise in Blasting and Cruising on steroids 1:01:26 Superdrol at the End of a Cut to Get Freaky or Adding Tren and using Winstrol + Trenbolone vs Superdrol and Winstrol Effects best steroid cycles ULTIMATE GUIDE TO ROIDS #1 BOOK ON TRUTH IN THE HISTORY OF BODYBUILDING bodybuilderinthailand.com/ultimate-guide-to-roids/ submit your questions for the next episode at: steroidspodcast.com instagram.com/bodybuilderinthailand User-59382539 – The-official-steroids-podcast-episode-1 This Podcast is for entertainment and conversational purposes only. This author does not support the use of illegal performance enhancing drugs. If any substances mentioned in this video are illegal in your country do not use them. Consult a doctor before beginning any exercise or supplement routine. Do not take anything mentioned in this video as advice. It is simply conversation, not advice.

We'd love to hear from you with ideas, suggestions, feedback, and questions for Dr. Henry or Dr. Yurkeiwicz at podcasts@mdedge.com and you can follow MDedge Hematology/Oncology at @MDedgeHemOnc.   Blood & Cancer episode 10:CDK4/6 inhibitors in breast cancer Richard Finn, MD, of the Geffen School of Medicine at UCLA joins guest host Jame Abraham, MD, of the Cleveland Clinic to discuss CDK4/6 inhibitors in the treatment of breast cancer, from the first pivotal studies to efficacy and patient selection. Later, Ilana Yurkiewicz, MD, talks about why it’s problematic to tell patients there is no more treatment in this week’s Clinical Correlation. Dr. Yurkiewicz is a fellow in hematology and oncology at Stanford University and is also a columnist for Hematology News.   Show notes By Emily Bryer, DO, Resident in the department of internal medicine, University of Pennsylvania. Cyclin dependent kinase 4 and 6 (CDK4/6) control phosphorylation of the retinoblastoma gene product in the G1 to S transition of the cell cycle. Luminal ER-positive HER2-negative breast cancers are most sensitive to inhibition with a CDK4/6 inhibitor and act synergistically with tamoxifen. PALOMA 1 trial studied CDK4/6 Inhibitors in ER-positive breast cancer. Letrozole alone (10-month PFS) versus letrozole plus palbociclib (greater than 20-month PFS) Toxicity = grade 3 (ANC 500-1000) and grade 4 neutropenia (ANC less than 500) Low incidence of neutropenic fever Palbociclib and chemotherapy have distinct effects on the bone marrow. Palbociclib is cytostatic (also, toxicity is predictable and not cumulative) Chemotherapy is cytocidal Although efficacy is similar between CDK4/6 inhibitors (PFS hazard ratio +/-0.5), side effects vary. Ribociclib and palbociclib have a higher incidence of neutropenia Ribociclib affects QTC interval and liver enzymes Abemaciclib is associated with diarrhea and venous thromboembolism Ongoing studies are exploring 1) CDK4/6 inhibitor plus endocrine therapy versus endocrine therapy alone and 2) CDK4/6 inhibitors in the adjuvant setting. The population to most benefit from CDK4/6 inhibitors may include the patients who are high-risk for relapse following endocrine therapy alone (previously those who would also receive chemotherapy). Additional reading N Engl J Med 2018; 379:1926-36. Breast Cancer. 2018 Jul;25(4):402-6.

In Fertility Gab's 3rd episode, we discuss Gabby's UNsuccessful 2nd round of Letrozole. BOOOOOO!!! We also talk about how encouragement can be found from this AMAZING community--it can even be found in cute necklaces. Enjoy!

In this episode, Gabby catches up on how her first full cycle with Letrozole went. It was...interesting.

In this episode, Gabby discusses her first month of taking Letrozole while trying to get pregnant. She discusses her symptoms, ovulation testing, and what is next on her TTC journey. Thanks for listening! If you have any questions or if you want to share your TTC journey, please reach out at fertilitygab@gmail.com!

December 16, 2015 PCOS Diva Menopause “Now is a great time; every day is great time to make a lifestyle improvement and know that there is a payoff that comes with that, regardless of having the PCOS diagnosis.” -Dr. Rashmi Kudesia Menopause is increasingly on my mind. As I enjoy my mid-forties, menopause is looming in my immediate future. I have a lot of questions, starting with, “How will menopause affect me, as a woman with PCOS?” Dr. Rashmi Kudesia, a nationally respected reproductive endocrinologist, accomplished lecturer, and author of numerous scientific research articles and manuscripts in leading medical journals offers answers. In our recent podcast, she answered many of my burning questions about PCOS and menopause and offered her analysis of current PCOS/menopause research. In fact, she answered many of the questions that Divas frequently ask me about the topic. Listen in as we discuss Why women with PCOS and lifelong irregular menstrual cycles often have regular cycles as they approach menopause The differences between women with and without PCOS as they transition into menopause Whether there is an increased risk of cancer, heart disease and type II diabetes as we age The latest protocol for using Metformin, Letrozole, and Clomid Whether women with PCOS have a lengthened reproductive span Recommendations for hysterectomy.

Today I'm sharing a special solo episode with you. I'm weighing in on IUI with the use of Clomid and Letrozole and talking about what the research has to say about the success rates of these two popular drugs. If you've ever considered IUI, you'll want to tune into this episode, and check out the research for yourself! My Fertility Management Programs are designed to help you to master Fertility Awareness and take a deep dive into your cycles. Gain confidence charting your cycles, and gain deep insights into the connection between your health, your fertility, and your cycles. Click here for more information!  Topics discussed in today's episode: How effective is IUI? What is the difference between the pregnancy rate and the live birth rate? How to dissect "success" rates for IUI How do IUI success rates vary with age? What is the cumulative success rate of IUI and how does it differ from the success rate of an individual round? Does having more rounds of IUI increase your chances of conceiving? What are the side effects of Clomid? How do Clomid impact cervical mucus and your endometrial lining? Why up to 25% of women are resistant to Clomid What is Letrozole and how does it compare to Clomid for IUI? How do the pregnancy and miscarriage rates differ in women who use Clomid versus Letrozole? Why it's important to be critical of research studies Connect with Lisa: You can connect with Lisa on the Fertility Friday Website, and on Facebook and Twitter. Resources mentioned: FFP 138 | Post-Pill Amenorrhea | Why It Took 4 Years For Her Period To Come Back | Andrea Petrus FFP 141 | Surviving Hypothalamic Amenorrhea | Getting Your Period Back Without Fertility Drugs | Nicola Rinaldi FFP 109 | The Reality of Aging & Fertility | IVF & Assisted Reproductive Technology | The Future of Fertility Treatments | Dr. Marjorie Dixon FFP 127 | What Does a Normal Period Look Like? | How Much Am I Supposed To Bleed During My Period? | Lisa | Fertility Friday http://fertilityfriday.com/fertilityawareness http://fertilityfriday.com/pcos/ FFP 149 | The Truth About Ovulation Predictor Kits (OPKs) | Lisa | Fertility Friday Research Studies: Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate Extended letrozole regimen versus clomiphene citrate for superovulation in patients with unexplained infertility undergoing intrauterine insemination: a randomized controlled trial A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation Success Rate of Inseminations Dependent on Maternal Age? An Analysis of 4246 Insemination Cycles Join the community! Find us in the Fertility Friday Facebook Group Subscribe to the Fertility Friday Podcast on iTunes! Music Credit: Intro/Outro music Produced by J-Gantic A Special Thank You to Our Show Sponsor: This episode is sponsored by Anova Fertility! In 2016 Dr. Marjorie Dixon created Anova with the goal to be the leader in innovation, education, and communication for high quality and humanized fertility and reproductive care. Anova Fertility has created the first next-generation IVF lab in Canada. Anova is celebrating her 1st birthday this month. If you are in the Toronto area and are interested in learning more about IVF from Anova’s medical team, we welcome you to sign-up for IVF 101 Education Session at our centre. You can visit http://fertilityfriday.com/anova/ for more information. If you live out of the country you can email info@anovafertility.com to request a medical consultation over Skype (there is a fee associated with this service). To learn more about Dr. Marjorie Dixon, tune into our podcast together by clicking this link. Fertility Friday | Fertility Management Programs This episode is sponsored by my Fertility Management Programs! Master Fertility Awareness and take a deep dive into your cycles and how they relate to your overall health! Click here for more information!

Dr Zdenkowski talks to ecancertv at ASCO 2015 about the final analysis of a randomised comparison of letrozole versus observation as late reintroduction of adjuvant endocrine therapy (AET) for postmenopausal women with hormone receptor positive breast cancer after completion of prior AET. The results show that in postmenopausal women who had completed four or more years of AET for hormone receptor positive breast cancer showed significantly reduced the incidence of late invasive breast cancer events.

Dr Mamounas presents data at the San Antonio Breast Cancer Symposium 2016 about the impact of letrozole treatment up to, and beyond, 5 years on disease free survival of post-menopausal women with HR breast cancer who have completed previous adjuvant aromatase inhibitory therapy. From nearly 4000 patients enrolled, he describes a reduction in the that of distant recurrent disease and improvement in breast cancer free interval events, though notes that overall benefits on DFS did not meet statistical significance. Dr Mamounas also notes an elevated risk of thrombotic events after 2.5 for patients receiving letrozole past that point.

Dr Kaklamani speaks with ecancertv at SABCS 2016, reviewing the mornings press release session which she chaired. She highlights the work of Dr Terry Mamounas and Dr Ofir Cohen.

Dr Mamounas speaks with ecancertv at SABCS 2016 about the impact of letrozole treatment up to, and beyond, 5 years on disease free survival of post-menopausal women with HR positive breast cancer who have completed previous adjuvant aromatase inhibitory therapy. From nearly 4000 patients enrolled, he describes a reduction in the that of distant recurrent disease and improvement in breast cancer free interval events, though notes that overall benefits on DFS did not meet statistical significance. Dr Mamounas also notes an elevated risk of thrombotic events after 2.5 for patients receiving letrozole past that point.

Dr Goss presents at ASCO 2016, a Randomised​ Phase III Open Label Trial which looked at extending adjuvant letrozole for 5 years after completing an initial 5 years of aromatase inhibitor therapy alone or preceded by tamoxifen in postmenopausal women with early-stage breast cancer.

Dr Lemieux speaks with ecancertv at ASCO 2016 with results from MA.17R, a randomised trial in which doubling the duration of letrozole treatment for postmenopausal women with early stage breast cancer resulted in significantly improved survival. She reports on the increased rate of progression-free survival, and patient outcomes beyond relapse rate.

Transhumanist Book http://www.amazon.com/Transhumanism-Grimoire-Alchemical-Scott-Hart-ebook/dp/B00AJOX1IU/ref=sr_1_2?ie=UTF8&qid=1434043796&sr=8-2&keywords=Transhumanism Bloodwork guide http://fabfitover40.com/2015/05/27/the-importance-of-regular-blood-work/ http://www.dangerandplay.com/2014/06/24/male-athletic-anti-aging-blood-work/ The TRT Solution on Jay’s site http://fabfitover40.com/2014/07/02/trt-diet/ Puffy Nipple Medications: Anti Estrogen Medications > Without using supplemental TRT these medications have the potential to drive your estrogen too low-But still better option than Surgery. Aromatase Inhibitors (AI’s) and Selective Estrogen Receptor Modulators (SERM’s)> Letrozole, Arimidex, Raloxifene, Nolvadex, Aromasin, http://researchstop.com/ http://www.maximpeptide.com/ A1C blood test to check insulin sensitivity - Glucometer (30 USD) Listen to our Hangouts to get all of the information regarding this: https://www.youtube.com/playlist?list=PLTtUCVGSJ6B9CDEws_jAaRRixIT4A0Vvl FabFitOver40.com http://fabfitover40.com/new-start-here/ Get Serious Book (Best book on changing your lifestyle) http://www.amazon.com/exec/obidos/ASIN/1940598206/fabfitove40-20 Get Serious 2 Book Coming (This link has a TOC) http://fabfitover40.com/2015/03/03/fabfitover40-and-drbrettosborn-upcoming-calendar/ SOARForever.com - 2 day seminars. www.soarforever.com Testosterone Book www.fabfitover40.com/trt

What is the safest, fastest, and cheapest way to get pregnant in fertility treatment? How long should you continue to try Clomid or Letrozole and/or artificial insemination (IUI) with our without injectables before moving to IVF? Host Dawn Davenport interviews Dr. Alison Zimon, a reproductive endocrinologist at Boston IVF, and Dr. Samantha Pfeifer, Associate Professor of Obstetrics and Gynecology at University of Pennsylvania Medical School. Blog summary of the show and highlights can be found here:   Blog summary of the show   Highlights   More Creating a Family resources on infertility can be found here. Support the show (https://creatingafamily.org/donation/)

Background: The objective of this prospectively randomized phase II trial (Trial registration: EUCTR2004-004007-37-DE) was to compare the clinical response of primary breast cancer patients to neoadjuvant therapy with letrozole alone (LET) or letrozole and zoledronic acid (LET + ZOL). Methods: Patients were randomly assigned to receive either LET 2.5 mg/day (n = 79) or the combination of LET 2.5 mg/day and a total of seven infusions of ZOL 4 mg every 4 weeks (n = 89) for 6 months. Primary endpoint was clinical response rate as assessed by mammogram readings. The study was terminated prematurely due to insufficient recruitment. We report here on an exploratory analysis of this data. Results: Central assessment of tumor sizes during the treatment period was available for 131 patients (66 LET, 65 LET + ZOL). Clinical responses (complete or partial) were seen in 54.5% (95% CI: 41.8-66.9) of the patients in the LET arm and 69.2% (95% CI: 56.6-80.1) of those in the LET + ZOL arm (P = 0.106). A multivariate model showed an OR of 1.72 (95% CI: 0.83-3.59) for the experimental arm. Conclusion: No increase in the clinical response rate was observed with the addition of ZOL to a neoadjuvant treatment regimen with LET. However a trend towards a better reponse in the LET + ZOL arm could be observed. This trend is consistent with previous studies that have investigated the addition of ZOL to chemotherapy, and it may support the evidence for a direct antitumor action of zoledronic acid.

Prof Finn talks to ecancer at at the IMProving care And Knowledge through Translational research (IMPAKT) meeting in Brussels, May 2012, about the results of a randomized phase 2 study of PD 0332991, a cyclin-dependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs letrozole alone for firstline treatment of ER+/HER2- advanced breast cancer. The new compound has the potential to be a standard of care in this setting, if a phase 3 study is successful, and also has promise in the adjuvant setting.

This Podcast reviews the background of the MA.17 trial, the results of the present manuscript and provides perspective on the current findings.

Audio Journal of Oncology, December 15th, 2007 Reporting from: San Antonio Breast Cancer Symposium, 13-16 December, 2007 New Drug RAD001 Plus Letrozole In Neoadjuvant Therapy For Breast Cancer JOSE BASELGA, Vall d’Hebron Hospital, Barcelona REFERENCE: ABSTRACT 2066 RAD001, a drug targeted at the mTor pathway, has been combined with letrozole in a randomised phase II trial in breast cancer. The investigators saw more responses in the experimental arm, and so Derek Thorne got the details from Jose Baselga of Vall d’Hebron Hospital in Barcelona.