Podcast appearances and mentions of stephen friend

February 10th, 2025 - We welcome back Mike Koeniger to talk about the DOGE effect. Then we're joined again by Stephen Friend to discuss how to fix the FBI. TheStationOfTheCross.com/ACT  

In this episode, Carl Jackson interviews FBI whistleblower Stephen Friend about the nomination of Cash Patel as FBI director. They discuss Patel's qualifications, the need for reform within the FBI, and strategies for addressing public concerns and narratives surrounding the agency. Friend emphasizes the importance of dismantling the current incentive structures within the FBI and suggests immediate actions Patel could take to initiate reform. The conversation concludes with a focus on how the new leadership can effectively communicate their mission to the public. Facebook: https://www.facebook.com/carljacksonradio Twitter: https://twitter.com/carljacksonshow Parler: https://parler.com/carljacksonshow Instagram: https://www.instagram.com/thecarljacksonshow  http://www.TheCarlJacksonShow.com NEW!!!! THE CARL JACKSON SHOW MERCH IS HERE. SUPPORT THE PODCAST GETTING A T-SHIRT NOW!  https://carljacksonmerch.itemorder.com  See omnystudio.com/listener for privacy information.

In this episode, Carl Jackson interviews FBI whistleblower Stephen Friend about the nomination of Cash Patel as FBI director. They discuss Patel's qualifications, the need for reform within the FBI, and strategies for addressing public concerns and narratives surrounding the agency. Friend emphasizes the importance of dismantling the current incentive structures within the FBI and suggests immediate actions Patel could take to initiate reform. The conversation concludes with a focus on how the new leadership can effectively communicate their mission to the public. Facebook: https://www.facebook.com/carljacksonradio Twitter: https://twitter.com/carljacksonshow Parler: https://parler.com/carljacksonshow Instagram: https://www.instagram.com/thecarljacksonshow  http://www.TheCarlJacksonShow.com NEW!!!! THE CARL JACKSON SHOW MERCH IS HERE. SUPPORT THE PODCAST GETTING A T-SHIRT NOW!  https://carljacksonmerch.itemorder.com  See omnystudio.com/listener for privacy information.

12 - Hunter Biden has been pardoned by his father! We dive into why this is so problematic and how the mainstream media is reacting to the news. 1210 - The media pulls out the “only son” card as justification for Joe pardoning Hunter. Kash Patel will head the FBI, is he the most important candidate to get confirmed? 1215 - Side - father son combo. More on Person of The Year. 1220 - More on Hunter Biden and your calls. Are they really going after Scott Presler? 1235 - Republican Candidate of NJ Governor Jack Cittarelli joins us today. What is he most concerned about right now? What will he do to help law enforcement? Jack compares himself to other candidates that have lost their races before ultimately winning and succeeding. 1250 - The View argues that it's okay what Hunter did because he's a drug addict. Dom vehemently disagrees. 1 - Lawyer and National Review columnist Andy McCarthy joins us. What would Andy do with the power to pardon? Why did Joe Biden wait until now to pardon Hunter after repeated promises that he wouldn't? How does Andy feel about the shield put up around Hunter over his drug use? Why even have the trial if everybody knew this outcome was coming? What will happen in the Daniel Penny case? 110 - How much should you tip the Christmas tree guy? 120 - Is the Trump administration standing with Big Vape? A SCOTUS case is being heard today over the advertisement of vaping towards children. Your calls on tips. 135 - Person of the Year discussion. Have Democrat positions gone too far left for voters in the area? Is Tim Walz daughter serious? Your calls. 150 - Dan time, family pet time. 2 - Special agent and friend of the show, Stephen Friend joins us today. He's happy Hunter Biden was pardoned? Stephen details the Hunter Biden case to one Bill Cosby. Why were Catholics at midnight mass targeted by the government? What will Kash Patel's appointment mean for the FBI and January 6th? How can the FBI be downsized? 215 - Money Melody! 220 - Winner! More on Hunter Biden's pardon and the resulting fallout. 230 - NJ Congressman Jeff Van Drew is back on the show. What are his takeaways from the Hunter Biden pardon? How will the Trump cabinet nominees fare on their votes? Jeff details the change that Americans are yearning for and how these nominees will help institute that if sworn in, which they should be. Should Jeff Van Drew throw his hat into the NJ governor's race? 250 - Lightning Round!

2 - Special agent and friend of the show, Stephen Friend joins us today. He's happy Hunter Biden was pardoned? Stephen details the Hunter Biden case to one Bill Cosby. Why were Catholics at midnight mass targeted by the government? What will Kash Patel's appointment mean for the FBI and January 6th? How can the FBI be downsized? 215 - Money Melody! 220 - Winner! More on Hunter Biden's pardon and the resulting fallout. 230 - NJ Congressman Jeff Van Drew is back on the show. What are his takeaways from the Hunter Biden pardon? How will the Trump cabinet nominees fare on their votes? Jeff details the change that Americans are yearning for and how these nominees will help institute that if sworn in, which they should be. Should Jeff Van Drew throw his hat into the NJ governor's race? 250 - Lightning Round!

More coming out about Bret Baier's interview with Vice President Kamala Harris on Fox News yesterday; A political betting platform says Trump is now the favorite to win the election by 62% after Kamala's interview; GUEST: FBI whistleblower and best-selling author Stephen Friend joins the program to discuss his former agency releasing the statistics in the rise of violent crimes.See omnystudio.com/listener for privacy information.

Larry is at an event with Tucker Carlson in Milwaukee, WI so Carl Jackson is guest hosting; There was a second assassination attempt on former president Donald Trump that was thwarted over the weekend, and Democrats want to blame Trump and JD Vance's rhetoric for it; GUEST: FBI whistleblower Stephen Friend comes on the show to explain the lapse of secret service for Trump; Dissecting the second sit-down interview that Kamala Harris has done as the Democratic nominee... And it's the worst one yet.See omnystudio.com/listener for privacy information.

Facebook: https://www.facebook.com/carljacksonradio Twitter: https://twitter.com/carljacksonshow Parler: https://parler.com/carljacksonshow Instagram: https://www.instagram.com/thecarljacksonshow http://www.TheCarlJacksonShow.com NEW!!!! THE CARL JACKSON SHOW MERCH IS HERE. SUPPORT THE PODCAST GETTING A T-SHIRT NOW! https://carljacksonmerch.itemorder.comSee omnystudio.com/listener for privacy information.

Facebook: https://www.facebook.com/carljacksonradio Twitter: https://twitter.com/carljacksonshow Parler: https://parler.com/carljacksonshow Instagram: https://www.instagram.com/thecarljacksonshow http://www.TheCarlJacksonShow.com NEW!!!! THE CARL JACKSON SHOW MERCH IS HERE. SUPPORT THE PODCAST GETTING A T-SHIRT NOW! https://carljacksonmerch.itemorder.comSee omnystudio.com/listener for privacy information.

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Garret O'Boyle and Stephen Friend dedicated years of their lives to serving their country in the FBI. But when they began to question some of the decisions being made within the bureau, they were suspended. After joining the FBI, O'Boyle says he “immediately saw that other agents [and] supervisors didn't have a solid grasp of people's civil rights.” “Having sworn that oath to the Constitution multiple times—twice in the Army, once as a police officer, once as an FBI agent,” O'Boyle said, “it actually meant something to me—which, I think, it doesn't to many, maybe even to most at this point. It's just a job.O'Boyle explained that FBI agents take a constitutional law course at the FBI Academy in Quantico, Virginia, and that for him, following and protecting constitutional rights “was most important to me,” adding that “foolishly … I thought that would be the case for everybody entering into this type of field.” After questioning some of the decisions being made within the FBI, O'Boyle was unexpectedly suspended from the bureau in 2022. Friend has a story similar to O'Boyle's. He was assigned to work on Jan. 6 cases, but raised concerns when he was informed that a SWAT team was to be used to arrest a man who was at the Capitol on Jan. 6, despite the fact that the man had agreed to cooperate with the investigation. Friend said he told his superiors, “We should not be doing this. There's other avenues to do it,” referring to arresting the man. Shortly thereafter, Friend was suspended from the FBI. O'Boyle and Friend join “The Daily Signal Podcast” to detail the issues they witnessed within the FBI and what happened to them when they started asking questions.Enjoy the show! Hosted on Acast. See acast.com/privacy for more information.

Garret O’Boyle and Stephen Friend dedicated years of their lives to serving their country in the FBI. But when they began to question some of the decisions being made within the bureau, they were suspended. After joining the FBI, O’Boyle says he “immediately saw that other agents [and] supervisors didn’t have a solid grasp of […]

On today's program: Nathaniel Moran, U.S. Representative for the 1st District of Texas, reacts to the U.S. veto of a United Nations Security Council resolution calling for an immediate cease-fire in Gaza. Stephen Friend, former FBI Special Agent and

Nathaniel Moran, U.S. Representative for the 1st District of Texas, reacts to the U.S. veto of a United Nations Security Council resolution calling for an immediate cease-fire in Gaza.  Stephen Friend, former FBI Special Agent and Senior Fellow at Center for Renewing America, unpacks the Biden administration's weaponization of the federal government against political opponents following the arrest of Alexander Smirnov. Tony Perkins, President of Family Research Council, joins the program from Nashville where Washington Watch with Tony Perkins received the 2024 Television Impact Award at the National Religious Broadcasters Convention and highlights the newly updated FRC Issue Analysis, Hostility Against Churches Is On The Rise In The United States. Rob Rotola, Senior Pastor of Word of Life Church is Wichita, KS, discusses the ongoing incidents of vandalism and theft at his church that have even involved physical threats and police intervention. --- Support this podcast: https://podcasters.spotify.com/pod/show/loving-liberty/support

On this week's show, Keith spoke to Darren Carty on the updated budget report on the Irish Farmers Journal, Maria from Animal Health Ireland and Stephen Friend from the Newford Suckler Herd in Athenry.

Steve Friend spoke to Ditch & Tim Van Horn on Memphis Morning News about the process of being an FBI whistleblower in the middle of one of the most divided times in our country.  With politically charged bureaucracies magnified by a weaponized bureau, to step forward and speak out about what he thought broke FBI protocols, was a risky thing to do. But Steve Friend did it and continues his mission today to expose the corruption.  My Journey from Beat Cop to Suspended FBI Whistleblower. Stephen Friend had his dream job as an FBI special agent. After nearly a decade of combating violent crime, human trafficking, and child predators, he was reassigned to the FBI's unprecedented investigation of the political unrest at the United States Capitol on January 6, 2021.Support the show: https://www.newstalk989.com/personalities/memphis-morning-news/See omnystudio.com/listener for privacy information.

Establishment and Big Money Republicans are lining up behind Nikki Haley - as she plays the race card. She needs to explain why all of those white racist rednecks in South Carolina elected her governor — twice. Stephen Friend and Rep. Scott Perry join the conversation!See omnystudio.com/listener for privacy information.

Brandon believes that the emerging star of the GOP is Vivek Ramaswamy... Do you believe Vivek is the real deal? Candace Owens upsets her Conservative boss Ben Shapiro with Israel comments; GUEST: FBI whistleblower Stephen Friend comes on to the show, as he is featured in the new Dinesh D'Souza film "Police State"; Senate Democrats block bipartisan House Israel aid bill; Financial dreams and tips with Tatum... If you want it and work hard for it, God can help you turn the impossible into the possible; Oklahoma senator Markwayne Mullin tries to fight Labor leader in the Senate; Hillary Clinton calls for Hamas' elimination, says all bloodshed in Gaza is on its hands.  The Officer Tatum Show is now available on Apple Podcasts, Google Podcasts, Spotify, and SalemPodcastNetwork.com.See omnystudio.com/listener for privacy information.

Dinesh D'Souza Talks to FBI Whistleblower. How Police Agencies Became Corrupted and Mobilized Against Patriots.   FRIGHTENING REALITY Dinesh D'Souza Podcast https://youtu.be/odAyyRE4BOo?si=6XQn6z2m6ApbnrfG Dinesh D'Souza 753K subscribers 8,582 views Oct 31, 2023 The Dinesh D'Souza Podcast In this episode, Dinesh discusses how Halloween is about make-believe fear while “Police State” is about fear that is very real in this country. FBI whistleblower and author Stephen Friend joins Dinesh to discuss how the police agencies of government became corrupted and mobilized against patriots, Republicans, conservatives, and Christians. — Dinesh D'Souza is an author and filmmaker. A graduate of Dartmouth College, he was a senior domestic policy analyst in the Reagan administration. He also served as a research fellow at the American Enterprise Institute and the Hoover Institution at Stanford University. He is the author of many bestselling books, including "Illiberal Education," "What's So Great About Christianity," "America: Imagine a World Without Her," "The Roots of Obama's Rage," "Death of a Nation," and "United States of Socialism." His documentary films "2016: Obama's America," "America," "Hillary's America," "Death of a Nation," and "Trump Card" are among the highest-grossing political documentaries of all time. He and his wife Debbie are also executive producers of the acclaimed feature film "Infidel." — Want to connect with Dinesh D'Souza online for more hard-hitting analysis of current events in America? Here's how: Get Dinesh unfiltered, uncensored and unchained on Locals: https://dinesh.locals.com/ Facebook:   / dsouzadinesh   Twitter:   / dineshdsouza   Rumble: https://rumble.com/dineshdsouza Instagram:   / dineshjdsouza   Parler: https://parler.com/user/DineshDSouza GETTR: https://gettr.com/user/dineshdsouza Email: https://dineshdsouza.com/contact-us/ We would like to thank our advertisers for our podcast: This podcast is brought to you by Dr. Kirk Elliot PHD. If you're looking for wealth management solutions and financial advice, go to kirkelliottphd.com and make an appointment today. https://www.mypillow.com Discount code “DINESH” https://www.relieffactor.com or call 800-4-RELIEF https://www.balanceofnature.com Discount code “America) https://www.birchgold.com text “DINESH” to 989898 https://myphdweightloss.com Call 864-644-1900 Books or guest info: Steve Friend – Author True Blue: My Journey from Beat Cop to Suspended FBI Whistleblower NEW MOVIE POLICE STATE! FOR STREAMING GO TO: https://policestatefilm.net https://www.amazon.com/Archipelago-Ab... https://dineshdsouza.com https://dinesh.locals.com to join Dinesh's page and support his work! Trump Card DVD: http://salemnowstore.com/ Our movie Infidel https://www.infidel911.com Watch Danielle D'Souza Gill Counter Culture Show -click below: https://www.theepochtimes.com/anti-am... Want to help the Jan 6 families? Here's a place to start and where we donate to: Movies https://www.trumpcardthemovie.com https://www.infidel911.com Songs Debbie D'Souza sings America The Beautiful music video    • This Rendition of "America the Beauti...   Trump Card Original Soundtrack available on iTunes Danielle D'Souza Gill books The Choice: The Abortion Divide in America – Danielle D'Souza Gill https://www.barnesandnoble.com/w/the-... More of Dinesh D'Souza Books: https://www.barnesandnoble.com/w/what... https://www.barnesandnoble.com/w/the-... https://www.barnesandnoble.com/w/amer... https://www.barnesandnoble.com/w/unit... https://www.barnesandnoble.com/w/deat... https://www.barnesandnoble.com/w/the-... https://www.barnesandnoble.com/w/rona... https://www.barnesandnoble.com/w/the-...

In this episode, Dinesh discusses how Halloween is about make-believe fear while “Police State” is about fear that is very real in this country.  FBI whistleblower and author Stephen Friend joins Dinesh to discuss how the police agencies of government became corrupted and mobilized against patriots, Republicans, conservatives, and Christians. Financial advisor Dr. Kirk Elliott joins Dinesh to outline a financial strategy for today's volatile environment.See omnystudio.com/listener for privacy information.

Speaker of the House Kevin McCarthy calls for impeachment inquiry into President Biden. How much longer will McCarthy remain speaker? Biden administration in a nutshell: Let's make a deal with a terrorist regime on anniversary of 9/11 while North Korea makes a deal with Russia. Mitch McConnell was on "Jeopardy!"?? FBI whistleblower Stephen Friend discusses the problems with the federal law enforcement agency and his solution to fix it. Is this video of Saturn real?? Learn more about your ad choices. Visit megaphone.fm/adchoices

This podcast is a commentary and does not contain any copyrighted material of the reference source. We strongly recommend accessing/buying the reference source at the same time. ■Reference Source https://www.ted.com/talks/stephen_friend_the_hunt_for_unexpected_genetic_heroes ■Post on this topic (You can get FREE learning materials!) https://englist.me/86-academic-words-reference-from-stephen-friend-the-hunt-for-unexpected-genetic-heroes-ted-talk/ ■Youtube Video https://youtu.be/q3-ye8XUUVc (All Words) https://youtu.be/5QmSXnqg3Lk (Advanced Words) https://youtu.be/IbaRG7_8CTg (Quick Look) ■Top Page for Further Materials https://englist.me/ ■SNS (Please follow!)

Save the Republic. Disarm the FBI Now, w/FBI whistleblower Stephen Friend More: www.TheCarljacksonshow.com Facebook: https://www.facebook.com/carljacksonradio Twitter: https://twitter.com/carljacksonshow Parler: https://parler.com/carljacksonshow http://www.TheCarlJacksonPodcast.comSee omnystudio.com/listener for privacy information.

Save the Republic. Disarm the FBI Now, w/FBI whistleblower Stephen Friend More: www.TheCarljacksonshow.com Facebook: https://www.facebook.com/carljacksonradio Twitter: https://twitter.com/carljacksonshow Parler: https://parler.com/carljacksonshow http://www.TheCarlJacksonPodcast.comSee omnystudio.com/listener for privacy information.

GUEST OVERVIEW: Stephen Friend had his dream job as an FBI special agent. After nearly a decade of combating violent crime, human trafficking, and child predators, he was reassigned to the FBI's unprecedented investigation of the political unrest at the United States Capitol on January 6, 2021. Friend soon uncovered efforts by the FBI and Department of Justice to manipulate statistics and exaggerate the nationwide threat of domestic terrorism. Friend spotlighted how the politicized FBI was cooking the books to support an ongoing narrative from the Joe Biden administration to label Donald Trump voters as violent extremists.

Mike Slater is back with Breitbart News Daily and he's got a complete breakdown of what happened yesterday with FBI Director Chris Wray and The House Judiciary Committee and what it all means.Following this, Slater gets a chance to talk to FBI whistleblower Steve Friend who has his own thoughts on the hearing and what the agency has ACTUALLY been up to over the last few years.

On Huckabee, Stephen Friend is an FBI Special Agent turned whistleblower. He exposes the FBI's manipulative investigation tactics, discusses his suspension from duty, and delves into the corrective actions necessary for reform within America's premier law enforcement agency. Sean McLelland is the executive director of Outdoors Tomorrow Foundation (OTF) and, as an avid outdoorsman, he's advocating for getting kids outdoors. Joel Rosenberg discusses his latest novel, “The Libyan Diversion,” and examines the alarming possibility of a similar attack on America. Don't miss Huckabee! Learn more about your ad choices. Visit megaphone.fm/adchoices

0:00 - Dan & Amy break down Joey Chestnut's 16th straight victory at the Nathan's hotdog eating contest    9:19 - THE GREAT DISINTEGRATION: Trans mass shooter in Philly   24:53 - Dan & Amy go back to 2017 and remember John Stossel's mall bake sale, a response to Affirmative Action Bake Sale at Bucknell   41:58 - Dan & Amy respond to Jen Psaki's theory:  GOP recruiting Muslims is Southern Strategy redux   55:36 - Why Dan Proft is single    58:51 - Dominic Green, columnist for The Washington Examiner, contributor to the Wall Street Journal and Fellow of the Royal Historical Society, on The French Riots and the Broader European Underclass. For more from Dominic @DrDomincGreen   01:16:20 - Noted economist Stephen Moore: Bidenomics Is a Big Bust. For more from Steve @StephenMoore   01:30:20 - Why Dan Proft is Single, part II   01:32:57 - Teresa Mull, assistant editor at Spectator World, shares details from her soon to be released book Woke-Proof Your Life A Handbook on Escaping Modern, Political Madness and Shielding Yourself and Your Family by Living a More Self-Sufficient, Fulfilling Life - Available 8/15 01:47:45 - FBI Whistleblower, Stephen Friend, discusses his testimony before the Select Subcommittee on the Weaponization of the Federal Government of the House Judiciary Committee. For more on Stephen's “journey from landing his dream job as an FBI special agent to his ultimate suspension after his bombshell allegations in a whistleblower disclosure” - check out his book True Blue: My Journey from Beat Cop to Suspended FBI WhistleblowerSee omnystudio.com/listener for privacy information.

On today's show, we talk about what really happened to Titan submersible that imploded on the wreck of the RMS Titanic. We debunk all those conspiracies about the Titan sub Incident and the connection to the US Navy. Source: The US Navy Knew about the Titan Submersible implosion. https://thepostmillennial.com/breaking-us-navy-detected-titan-implosion-on-sunday-but-biden-admin-only-released-news-on-thursday-after-hunter-plea-deal-and-whistleblower-reports-released  Conspiracies abound about the Titan Submersible. https://100percentfedup.com/just-in-biden-knew-titan-submarine-imploded-days-ago-and-withheld-information-to-distract-news-cycle-from-his-scandals/ How the US Navy knew, remains tight lit. https://redstate.com/bobhoge/2023/06/22/report-u-s-navy-heard-what-it-believed-to-be-titan-implosion-soon-after-voyage-began-n765699 Recovering the Remains is next to impossible. https://nypost.com/2023/06/23/can-the-bodies-from-the-titanic-sub-be-recovered-following-the-implosion/   Audible Book recommend True Blue by Stephen Friend https://amzn.to/44cZlzO The Great Reset: And the War for the World by Alex Jones https://amzn.to/3JurU3S   Support my affiliates Podbean affiliate: https://www.podbean.com/NCPB Advertise on Podbean: https://sponsorship.podbean.com/NCPB Audible Gift Memberships: https://amzn.to/3of4yqZ Try Audible Plus: https://amzn.to/41yjsXV Shop MyID: https://lddy.no/1frus Ebay Deals: https://t.ly/oBfE Amazon Deals: https://amzn.to/3JhPnoK Try Shibari Study. https://shibaristudy.com/?referral_code=ieeHaHHDeFgF

Stephen Friend had his dream job as an FBI special agent. After nearly a decade of combating violent crime, human trafficking, and child predators, he was reassigned to the FBI's unprecedented investigation of the political unrest at the United States Capitol on January 6, 2021. Friend soon uncovered efforts by the FBI and Department of Justice to manipulate statistics and exaggerate the nationwide threat of domestic terrorism. Friend spotlighted how the politicized FBI was cooking the books to support an ongoing narrative from the Joe Biden administration to label Donald Trump voters as violent extremists. Friend witnessed overzealous practices to harass conservative Americans and realized the FBI was turning its investigative processes into a punishment. When the married father of two made his bombshell allegations in a whistleblower disclosure, leaders within the FBI exposed themselves as partisan, ambitious players who insisted that January 6th protestors killed police officers and attempted to seize American democracy. Hell-bent on suppressing Friend from exposing the truth, FBI officials seized his gun and badge and suspended him from working as a special agent. In this memoir, Friend reflects on the lessons and life experiences that led him to ultimately risk his career to uphold his FBI special agent oath to protect and defend the United States Constitution against all enemies—both foreign and domestic. Become a member at https://plus.acast.com/s/unimpressedpodcast. https://plus.acast.com/s/unimpressedpodcast. Hosted on Acast. See acast.com/privacy for more information.

Stigall explains why some conservatives on social media are getting way out over their skis trying to lump beer brand Yuengling into the culture fight all Target and Bud Light. Cheryl Chumley at the Washington Times discusses her powerful column "America's Time of Choosing: God of Evil." FBI whistleblower Stephen Friend explains what's happened to the culture inside the FBI since he joined 10 years ago and where their priorities lie today in his new book "True Blue: My Journey from Beat Cop to Suspended FBI Whistleblower." And Tucker Carlson returns with an epic Twitter monologue Stigall can't wait to discuss with you! plus - your final day to join the Harrumph Society for Father's Day at just $30 for the whole year. Don't miss it and Happy Father's Day! -For more info visit the official website: https://chrisstigall.comInstagram: https://www.instagram.com/chrisstigallshow/Twitter: https://twitter.com/ChrisStigallFacebook: https://www.facebook.com/chris.stigall/Listen on Spotify: https://tinyurl.com/StigallPodListen on Apple Podcasts: https://bit.ly/StigallShowSee omny.fm/listener for privacy information.

What does a politicized police force do to a whistleblower? You'll be amazed at the vindictive and vicious dirty tricks they tried. But Stephen Friend kept his integrity and kept out of jail. And now he's written a must-read book, "TRUE BLUE: My Journey from Beat Cop to Suspended FBI Whistleblower" just released yesterday.Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Money is only what YOU hold: Go to DavidKnight.gold for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to TrendsJournal.com and enter the code KNIGHT

What does a politicized police force do to a whistleblower? You'll be amazed at the vindictive and vicious dirty tricks they tried. But Stephen Friend kept his integrity and kept out of jail. And now he's written a must-read book, "TRUE BLUE: My Journey from Beat Cop to Suspended FBI Whistleblower" just released yesterday.Find out more about the show and where you can watch it at TheDavidKnightShow.comIf you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-showOr you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Money is only what YOU hold: Go to DavidKnight.gold for great deals on physical gold/silverFor 10% off Gerald Celente's prescient Trends Journal, go to TrendsJournal.com and enter the code KNIGHT

Hour 1 * Guest: Chris Carlson – Without God, we can never win, With God, we can never lose, The Battle for Freedom is the Lord's, but we need to be engaged in the fight! * Go to a school board meeting? FBI might have your license plate number – Bob Unruh, WND.com * FBI agents were tasked with writing down license plate numbers of those attending, in order to spy on them and document their actions – FBI whistleblower Stephen Friend told members of the House Judiciary Select Committee on the weaponization of the federal government that he was among the agents being given those orders. * The Durham Report: A Scathing Whitewash – Joel Skousen, WorlfAffairsBrief.com * Crossfire Hurricane was the internal code name for an investigation by the FBI that began in 2016 to look into possible links between the then-Trump campaign and Russia. Special Counsel John Durham found that the FBI did not have enough ‘factual evidence' to investigate allegations of Trump-Russia collusion… * FBI employees used high-level intelligence and law-enforcement positions to promote misinformation that affected at least two presidential elections, always on behalf of Democrats. * FBI Protecting Biden From Prosecution For Bribery – It goes even deeper than refusing a congressional subpoena – TheEpochTimes.com * The FBI refused to comply with the subpoena's May 10 deadline. House Republicans appear split on whether to hold FBI Director Christopher Wray in contempt of Congress for not complying with a subpoena from the House Oversight Committee that seeks a document with whistleblower allegations that now-President Joe Biden received a bribe from a foreign official. * Why should the republicans be split on such a clear cut matter? Because a lot of Republicans are compromised just like Democrats. * The Main Stream media are part of the Deep State, whose job is to give cover for Deep State puppet presidents and government officers. * If Tucker Carlson is such a hard-hitting conservative tv talk show host, why does he have so many deep-state connections? * Tucker Carlson left the Weekly Standard to write for the New York Times, New York Magazine, the Wall Street Journal, Esquire, Slate, The New Republic, Reader's Digest and the Daily Beast. He would also appear on CNN, MSNBC, PBS and Fox. He also made cameo appearances on King of Queens, Thirty Rock, and Dancing with the Stars. * Tucker Carlson calls 911 truth tellers “parasites”! Hour 2 * URGENT: WHO meeting begins Sunday! * 1 Billionaire to rule us all – Mat Staver, Liberty Counsel – libertyaction.org This same billionaire is using his deep pockets to establish the World Health Organization (WHO) as a global authority to do his bidding. * The only thing that stands in his way is our ability to wake up our sleeping members of Congress and demand they STOP Joe Biden from signing America on to Bill Gates' WHO amendments. * American sovereignty is NOT FOR SALE. Tell Congress to STOP Joe Biden's attempt to give our freedom to a billionaire's pet project — the WHO. * Don't let Joe Biden put America under Bill Gates' WHO control! * Bill Gates, in 2010 told the world he wanted to reduce the global human population by 10-15% through “new vaccines,” among other things – The Gates Foundation was established in 1994, and in the year 2000 was renamed the Bill and Melinda Gates Foundation (BMGF) — now the second largest “charity” in the world. * Bill Gates attempts to force his corrupt will on the entire world. In one year, he spent 8.3 million dollars lobbying to receive billions from America and other nations, all to enforce his will on YOU. * In 2021, Gates charities gave a staggering 1.4 billion dollars to the WHO, more than any other country in the world, including the US and Germany – That kind of money buys a lot of influence. * The Church of Jesus Christ of Latter-Day Saints receives $7 billion in donations from its 17 million members. --- Support this podcast: https://podcasters.spotify.com/pod/show/loving-liberty/support

Freaks, frauds and cockroaches - Shaun exterminates them all! Randy Donley calls in to tell Shaun and heartwarming story and give Tunnel2Towers a generous donation. PLUS, geopolitial analyst and author, Brandon Weichert, has been researching biotech in China since 2017 - he shares his findings in his new book Biohacked: China's Race to Control Life. And FBI whistleblower, Stephen Friend, tells Shaun his story and the reasonable concerns he brought forward that got him indefinately suspended from the FBI - you can read all about it in his new book True Blue: My Journey from Beat Cop to Suspended FBI Whistleblower, out next week!See omnystudio.com/listener for privacy information.

Full Hour | In today's second hour, Dom led off by telling of a new push by the PC Police, the Woke mob, who's looking to end customers complaining about their food for some odd political reason. This leads to Dan and Dom discussing other weird things that have been cancelled, including the usage of ‘aloha' as a greeting and the term ‘French' to describe… the French. Then, Dom leaps into a conversation about Sesame Street, with the court case heating up over whether character Rosalina is racist. Then, Dom welcomes in Stephen Friend, FBI Whistleblower and author of the upcoming True Blue: My Journey from Beat Cop to Suspended FBI Whistleblower, rejoins the Dom Giordano Program to offer his expertise on the news surrounding FBI head Christopher Wray, who faces a potential contempt hearing after holding documents and information related to Joe and Hunter Biden and the bias within the FBI. First, Friend tells how his life has been since testifying in front of Congress, blowing the whistle on how certain investigations related to politics were hampered by biased leadership. Then, Friend offers his thoughts on the topic at hand, explaining what Wray can and cannot do, and tells of the accountability he feels the leader may face from Congress. Also, Friend takes us inside the organization, telling what he believes lead to a shift in bias, and takes us inside his book, offering examples of bias he witness while serving as a Special Agent within the FBI. (Photo by Getty Images)

Dom welcomes in Stephen Friend, FBI Whistleblower and author of the upcoming True Blue: My Journey from Beat Cop to Suspended FBI Whistleblower, rejoins the Dom Giordano Program to offer his expertise on the news surrounding FBI head Christopher Wray, who faces a potential contempt hearing after holding documents and information related to Joe and Hunter Biden and the bias within the FBI. First, Friend tells how his life has been since testifying in front of Congress, blowing the whistle on how certain investigations related to politics were hampered by biased leadership. Then, Friend offers his thoughts on the topic at hand, explaining what Wray can and cannot do, and tells of the accountability he feels the leader may face from Congress. Also, Friend takes us inside the organization, telling what he believes lead to a shift in bias, and takes us inside his book, offering examples of bias he witness while serving as a Special Agent within the FBI. (Photo by Getty Images)

When North is Still North and doing anything but RIGHT isn't an option, life can sometimes find us in uncomfortable positions. Former FBI agents Stephen Friend explains how corruption in the FBI forced him to do the right thing, and the price he paid for doing it. PLUS, the remarkable story of two enemy pilots who became best friends 40 years after one pilot saved the other's life in the skies above Germany. Podcast Production: Bob Slone Audio Productions 

Bill Gates's past with Jeffrey Epstein is again boiling to the surface. It was already known that Gates had connections to the accused sex trafficker and convicted pedophile. In fact, Gates's wife previously said this was a key reason she divorced him. But the new evidence is exposing even more. Not only is it now apparent that Gates met with Epstein more than was previously thought, but it also appears that Epstein had tried blackmailing Gates over an affair with a Russian bridge player. Meanwhile, the nation watched last week as FBI whistleblowers made shocking allegations on how the agency has been punishing agents for refusing to break the law, or for refusing to carry out orders they view as unethical. They spoke during a hearing from the House Weaponization of the Federal Government Subcommittee. One of the agents was Stephen Friend, an FBI whistleblower, who joins us for a discussion. We'll discuss these stories, and why they matter, in this episode of Crossroads. ⭕️ Stay up-to-date with Josh with the Crossroads NEWSLETTER

* Guest: Chris Carlson - Without God, we can never win, With God, we can never lose, The Battle for Freedom is the Lord's, but we need to be engaged in the fight! * Go to a school board meeting? FBI might have your license plate number - Bob Unruh, WND.com * FBI agents were tasked with writing down license plate numbers of those attending, in order to spy on them and document their actions - FBI whistleblower Stephen Friend told members of the House Judiciary Select Committee on the weaponization of the federal government that he was among the agents being given those orders. * The Durham Report: A Scathing Whitewash - Joel Skousen, WorlfAffairsBrief.com * Crossfire Hurricane was the internal code name for an investigation by the FBI that began in 2016 to look into possible links between the then-Trump campaign and Russia. Special Counsel John Durham found that the FBI did not have enough 'factual evidence' to investigate allegations of Trump-Russia collusion... * FBI employees used high-level intelligence and law-enforcement positions to promote misinformation that affected at least two presidential elections, always on behalf of Democrats. * FBI Protecting Biden From Prosecution For Bribery - It goes even deeper than refusing a congressional subpoena - TheEpochTimes.com * The FBI refused to comply with the subpoena's May 10 deadline. House Republicans appear split on whether to hold FBI Director Christopher Wray in contempt of Congress for not complying with a subpoena from the House Oversight Committee that seeks a document with whistleblower allegations that now-President Joe Biden received a bribe from a foreign official. * Why should the republicans be split on such a clear cut matter? Because a lot of Republicans are compromised just like Democrats. * The Main Stream media are part of the Deep State, whose job is to give cover for Deep State puppet presidents and government officers. * If Tucker Carlson is such a hard-hitting conservative tv talk show host, why does he have so many deep-state connections? * Tucker Carlson left the Weekly Standard to write for the New York Times, New York Magazine, the Wall Street Journal, Esquire, Slate, The New Republic, Reader's Digest and the Daily Beast. He would also appear on CNN, MSNBC, PBS and Fox. He also made cameo appearances on King of Queens, Thirty Rock, and Dancing with the Stars. * Tucker Carlson calls 911 truth tellers "parasites"!

Full Hour | Today, Dom led off the Dom Giordano Program by offering his thoughts on the continued controversy over Florida's effort to protect children and parents. First, Dom plays back a clip from Governor Ron DeSantis, who explains his new gender-transition for minors ban, explaining that ‘if you're taking off the private parts of some 15-year-old, you should go to jail.' Then, Dom plays back a clip from MSNBC's Chris Hayes who uses God's name in vain to excoriate DeSantis's proposal, which Dom himself takes down as absolutely ridiculous. Then, Dom plays back clips from a hearing yesterday by the House Judiciary Committee into the bias propagated by the FBI in recent years, honing in on a back and forth between Congress Members Dan Bishop and Mary Gay Scanlon over the raid of Mark Houck's home, a pro-life activist who was later exonerated by a jury. Then, Dom welcomes in Stephen Friend, a FBI whistleblower who testified in front of Congress to the bias that's become pervasive in the FBI. Friend, who has a new book coming out in June, True Blue: My Journey from Beat Cop to Suspended FBI Whistleblower, spoke yesterday in front of elected officials, telling of his experiences as an FBI agent as the agency started pursuing parents at school board meetings and other politically biased efforts. Friend offers listeners a glimpse inside the changing law enforcement organization, and reveals the role that brass have in the politicization of the entity. Also, Friend previews his book, telling listeners where they can find it upon release. (Photo by Getty Images)

Dom welcomes in Stephen Friend, a FBI whistleblower who testified in front of Congress to the bias that's become pervasive in the FBI. Friend, who has a new book coming out in June, True Blue: My Journey from Beat Cop to Suspended FBI Whistleblower, spoke yesterday in front of elected officials, telling of his experiences as an FBI agent as the agency started pursuing parents at school board meetings and other politically biased efforts. Friend offers listeners a glimpse inside the changing law enforcement organization, and reveals the role that brass have in the politicization of the entity. Also, Friend previews his book, telling listeners where they can find it upon release. (Photo by Chip Somodevilla/Getty Images)

For America to be revived, there must first be a revival of American men. Sen. Josh Hawley joins Charlie to discuss his new book Manhood, how the Bible offers many heroic male role models, and why the concept of "toxic masculinity" misses the mark so badly about what ails America. Plus, whistleblowing federal agent Stephen Friend describes how the FBI has been warped into a weapon aimed at Americans, with agents ordered to hit quotas on so-called "domestic terrorism."Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

Kyle brings back frequent guest and #Suspendables co-founder @realSteveFriend (@Real_SteveFriend on TruthSocial) to give a "State of the Suspendables" update. Steve is a former police officer, a former FBI Agent, a federal whistleblower, author, and Senior Fellow at the Center for Renewing America. We talk "Happiness Seminars" and other absurdities on the day FBI Exec Asst Director Jenn Moore testifies to the Weaponization Committee. __________________________________________________________________________ Today's podcast supported by CatholicVote.Org If you are interested in supporting the going litigation against the FBI over religious liberties, you can visit CatholicVote.Org. Our product sponsor is PatriotCoolers.com: Use Promo code "KYLE" for 10% off and free shipping over $50. A big thanks to both of these great organizations.

Today at 5:00 PM | Patriots vs Globalists | A Real Discussion of Battlefield Conditions in America with FBI Whistleblower Steve Friend Buy Steve's Book: https://www.amazon.com/True-Blue-Journey-Suspended-Whistleblower/dp/B0BTC3M3B2/ref=sr_1_1?crid=BVBJOG7GL5M3&keywords=true+blue+stephen+friend&qid=1682193583&sprefix=%2Caps%2C105&sr=8-1 Prepare Yourself for What is to Come: https://warriormbs.com We are going to have an out loud discussion about the time for war against our own corrupt government. Stephen Friend had his dream job as an FBI special agent. After nearly a decade of combating violent crime, human trafficking, and child predators, he was reassigned to the FBI's unprecedented investigation of the political unrest at the United States Capitol on January 6, 2021. Friend soon uncovered efforts by the FBI and Department of Justice to manipulate statistics and exaggerate the nationwide threat of domestic terrorism. Friend spotlighted how the politicized FBI was cooking the books to support an ongoing narrative from the Joe Biden administration to label Donald Trump voters as violent extremists. Friend witnessed overzealous practices to harass conservative Americans and realized the FBI was turning its investigative processes into a punishment. When the married father of two made his bombshell allegations in a whistleblower disclosure, leaders within the FBI exposed themselves as partisan, ambitious players who insisted that January 6th protestors killed police officers and attempted to seize American democracy. Hell-bent on suppressing Friend from exposing the truth, FBI officials seized his gun and badge and suspended him from working as a special agent. In this memoir, Friend reflects on the lessons and life experiences that led him to ultimately risk his career to uphold his FBI special agent oath to protect and defend the United States Constitution against all enemies—both foreign and domestic.

Steven Friend is a former FBI agent who has simply had enough. In this interview he shares with us the true depth of agency corruption including the incentivised targeting of white men for domestic terrorism cases, and why the Nashville shooter manifesto will never be released. Steven Friend's New Book: https://www.amazon.com/True-Blue-Journey-Suspended-Whistleblower/dp/B0BTC3M3B2/ref=sr_1_1?crid=BVBJOG7GL5M3&keywords=true+blue+stephen+friend&qid=1682193583&sprefix=%2Caps%2C105&sr=8-1 Jeremy Slayden's Program for men to get their mind body and soul prepped for what is to come: WarriorMBS.com Stephen Friend had his dream job as an FBI special agent. After nearly a decade of combating violent crime, human trafficking, and child predators, he was reassigned to the FBI's unprecedented investigation of the political unrest at the United States Capitol on January 6, 2021. Friend soon uncovered efforts by the FBI and Department of Justice to manipulate statistics and exaggerate the nationwide threat of domestic terrorism. Friend spotlighted how the politicized FBI was cooking the books to support an ongoing narrative from the Joe Biden administration to label Donald Trump voters as violent extremists. Friend witnessed overzealous practices to harass conservative Americans and realized the FBI was turning its investigative processes into a punishment. When the married father of two made his bombshell allegations in a whistleblower disclosure, leaders within the FBI exposed themselves as partisan, ambitious players who insisted that January 6th protestors killed police officers and attempted to seize American democracy. Hell-bent on suppressing Friend from exposing the truth, FBI officials seized his gun and badge and suspended him from working as a special agent. In this memoir, Friend reflects on the lessons and life experiences that led him to ultimately risk his career to uphold his FBI special agent oath to protect and defend the United States Constitution against all enemies—both foreign and domestic.

While Tucker is busy taking bids on his services--can't wait to hear how much money get gets!--someone has to report on the continuing effort of the Mockingbird Media to pretend there is no reason to want to know more about Ray Epps. I volunteer. It's simple. People who went to D.C. and stood on the lawn have had the FBI roll-up heavy to their houses and frog-march them. Meanwhile, Epps, Scaffolding Man, the guys who took down the government barriers and signs designed to stop people from entering the Capitol are all walking around free. This cannot be made to make sense no matter how much air-time 60 Minutes donates to Epps. NOT WANTED: The guy tearing down this barrier. Image from Revolver.news. NOT WANTED: The guy who spent hours on a scaffolding, yelling through a bullhorn, telling people to “keep moving forward.” Image from Revolver.newsWhat does God say? Romans 13:1-14 Let every person be subject to the governing authorities. For there is no authority except from God, and those that exist have been instituted by God. Therefore whoever resists the authorities resists what God has appointed, and those who resist will incur judgment. For rulers are not a terror to good conduct, but to bad. Would you have no fear of the one who is in authority? Then do what is good, and you will receive his approval, for he is God's servant for your good. But if you do wrong, be afraid, for he does not bear the sword in vain. For he is the servant of God, an avenger who carries out God's wrath on the wrongdoer. Therefore one must be in subjection, not only to avoid God's wrath but also for the sake of conscience. ...Romans 12:19 Beloved, never avenge yourselves, but leave it to the wrath of God, for it is written, “Vengeance is mine, I will repay, says the Lord.”Proverbs 25:26 Like a muddied spring or a polluted fountain is a righteous man who gives way before the wicked.Joshua 1:9 Have I not commanded you? Be strong and courageous. Do not be frightened, and do not be dismayed, for the Lord your God is with you wherever you go.”EXCLUSIVE: Former FBI Agent Who Refused to Raid Jan. 6 Suspect Warns of Agency's Weaponization; Stephen Friend's Jan. 6 constitutional objections led him out of the Bureau6 Reasons The IRS Whistleblower Will Blow Open DOJ's Biden Family Protection Racket60 Minutes working for Ray Epps: “I'm probably gonna go to jail for this. Tomorrow, we need to go into the Capitol!” Ray Epps, a Marine veteran, yelled to a crowd the night before the Jan. 6 protest. Some thought Epps was an FBI plant sent to entrap them, which he and the FBI deny. 60 Minutes working for Ray Epps: Jan. 6 protester Ray Epps says during the insurrection he tried to keep the peace. Epps says he regrets sending a text to a relative that he “orchestrated it.” He claims he was “boasting to my nephew” and meant he was “directing people to the Capitol.”60 Minutes working for Ray Epps: “Ray Epps response to why he said, we must go into the Capitol: ‘I said some stupid things.'”60 Minutes working for Ray Epps: “‘He's obsessed with me,'” Ray Epps says of Fox News host Tucker Carlson. ‘He's … [trying] to destroy my life.' Carlson has focused on Epps more than 20 times on his show, which Epps says is to shift blame from those who really instigated rioters on Jan. 6.”60 Minutes working for Ray Epps: “Ray Epps was front and center at the first breach of Capitol grounds on January 6. He says he was trying to calm rioters down and keep the peace. But a far-right conspiracy casts him as a deep-state operative giving orders to initiate the attack.”60 Minutes working for Ray Epps: “After Epps spoke with the FBI, his photo was removed from the bureau's website. He thought his troubles were over, but it only added fuel to a far right-wing conspiracy theory targeting him.”60 Minutes working for Ray Epps: “After former President Trump mentioned Epps at a rally, Epps says harassment and death threats against him picked up. Epps and his wife sold their home and are now living in hiding.”60 Minutes working for Ray Epps: "If Ray Epps was a covert plant, he is the worst covert plant of all time,” says Tom Joscelyn, who helped author the Jan. 6 Committee's report on the insurrection. He says the committee interviewed Epps and found he wasn't important enough to include.”Alan's Soapshttps://alanssoaps.com/TODDUse coupon code ‘TODD' to save an additional 10% off the bundle price.BiOptimizershttps://magbreakthrough.com/toddUse promo code TODD for 10% off your order.Bonefroghttps://bonefrog.usEnter promo code TODD at checkout to receive 10% off your subscription. 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Stephen Friend had his dream job as an FBI special agent. After nearly a decade of combating violent crime, human trafficking, and child predators, he was reassigned to the FBI's unprecedented investigation of the political unrest at the United States Capitol on January 6, 2021. Friend soon uncovered efforts by the FBI and Department of Justice to manipulate statistics and exaggerate the nationwide threat of domestic terrorism. Friend spotlighted how the politicized FBI was cooking the books to support an ongoing narrative from the Joe Biden administration to label Donald Trump voters as violent extremists. Friend witnessed overzealous practices to harass conservative Americans and realized the FBI was turning its investigative processes into a punishment. When the married father of two made his bombshell allegations in a whistleblower disclosure, leaders within the FBI exposed themselves as partisan, ambitious players who insisted that January 6th protestors killed police officers and attempted to seize American democracy.

Buy Stephen's Book here: https://amzn.to/3K1GPloStephen Friend had his dream job as an FBI special agent. After nearly a decade of combating violent crime, human trafficking, and child predators, he was reassigned to the FBI's unprecedented investigation of the political unrest at the United States Capitol on January 6, 2021. Friend soon uncovered efforts by the FBI and Department of Justice to manipulate statistics and exaggerate the nationwide threat of domestic terrorism. Friend spotlighted how the politicized FBI was cooking the books to support an ongoing narrative from the Joe Biden administration to label Donald Trump voters as violent extremists. Friend witnessed overzealous practices to harass conservative Americans and realized the FBI was turning its investigative processes into a punishment. When the married father of two made his bombshell allegations in a whistleblower disclosure, leaders within the FBI exposed themselves as partisan, ambitious players who insisted that January 6th protestors killed police officers and attempted to seize American democracy. Support the showTry Hiatus: https://hiatus.pxf.io/RyABng#ifounditonamazon https://a.co/ekT4dNOTRY AUDIBLE PLUS: https://amzn.to/3vb6Rw3Elsa's Books: ...

Fresh from Congressional testimony, federal whistleblowers Stephen Friend and George Hill (see link) stop by to discuss the "flak" they are taking from "news" outlets like CNN, NYTimes, Rolling Stone, and WaPo. Kyle takes this former FBI Agent and retired FBI Senior Intel Analyst through the allegations made by House Democrats in their absurdly long 300+ page attempt to discredit them. The listener can decided from themselves if these are "extreme MAGA operatives" or not. Document links: https://democrats-judiciary.house.gov/uploadedfiles/2023-03-02_gop_witnesses_report.pdf  FBI Whistleblower Protection Act:(https://www.law.cornell.edu/uscode/text/5/2303) Steve's Book on Amazon "True Blue":

March 6th, 2023 - Stand up to the bullies! FBI whistleblower Stephen Friend joins us to talk about why you have to do the right thing even if you're the only one doing it...and even if you're in your dream job!

"Indefinitely Suspended" FBI Special Agent and whistleblower Stephen Friend speaks out about the oath of public service and asks why more federal employees aren't stepping up to the plate. Subscribe to my two podcasts: “The Sharyl Attkisson Podcast” and “Full Measure After Hours.” Leave a review, subscribe and share with your friends! Support independent journalism by visiting the new Sharyl Attkisson store. Order “Slanted: How the News Media Taught Us to Love Censorship and Hate Journalism” by Sharyl Attkisson at Harper Collins, Amazon, Barnes & Noble, Books a Million, IndieBound, Bookshop! --- Send in a voice message: https://anchor.fm/sharylattkissonpodcast/message

"Indefinitely Suspended" FBI Special Agent and whistleblower Stephen Friend speaks out about the oath of public service and asks why more federal employees aren't stepping up to the plate. Subscribe to my two podcasts: “The Sharyl Attkisson Podcast” and “Full Measure After Hours.” Leave a review, subscribe and share with your friends! Support independent journalism by visiting the new Sharyl Attkisson store. Order “Slanted: How the News Media Taught Us to Love Censorship and Hate Journalism” by Sharyl Attkisson at Harper Collins, Amazon, Barnes & Noble, Books a Million, IndieBound, Bookshop! --- Send in a voice message: https://podcasters.spotify.com/pod/show/sharylattkissonpodcast/message

Stephen Friend and Kyle Seraphin earn an A grade on Saving America 208 for exposing the FBI's weaponizing anything remotely connected to Donald Trump or conservative causes. Thanks for joining me for this episode! I'm a Houston- based attorney, run an HR Consulting company called Claremont Management Group, and am a tenured professor at the University of St. Thomas. I've also written several non-fiction political commentary books: Bad Deal for America (2022) explores the Vegas-style corruption running rampant in Washington DC, while The Decline of America: 100 Years of Leadership Failures (2018) analyzes – and grades – the leadership qualities of the past 100 years of U.S. presidents. You can find my books on Amazon, and me on social media (Twitter @DSchein1, LinkedIn @DavidSchein, and Facebook, Instagram, & YouTube @AuthorDavidSchein). I'd love to hear from you! As always, the opinions expressed in this podcast are mine and my guests' and not the opinions of my university, my company, or the businesses with which I am connected.

"Participating in any way was going to be a moral problem." In this episode of the Whistleblower of the Week podcast, FBI whistleblower Jane Turner talks with Special Agent Steve Friend. Friend‘s allegations about the FBI's handling of the January 6, 2021, insurrection investigation made waves on Capitol Hill. Listen now, or catch the video version on WNN's YouTube channel!

Senator Rubio ad A proposed law in Virginia We need to be praying before we even open our mouths Pray for Stephen Friend an FBI whistleblower Engaging the World with a Devine Message Epicurean culture Working through the passage and letting the passage work through us. Caller John about his Counterfeit God Links: Counterfeit Gods by Tim Keller - https://www.amazon.com/Counterfeit-Gods-Empty-Promises-Matters-ebook/dp/B002TNGBJ0/ref=sr_1_1?crid=2H1498LIZUNW7&keywords=counterfeit+gods+keller&qid=1666034994&qu=eyJxc2MiOiIwLjAwIiwicXNhIjoiMC4wMCIsInFzcCI6IjAuMDAifQ%3D%3D&sprefix=counterfit+God%2Caps%2C1413&sr=8-1 ------------------ Acts 17:16-21 (ESV Strong's) Paul in Athens 16 Now while Paul was waiting for them at Athens, his spirit was provoked within him as he saw that the city was full of idols. 17 So he reasoned in the synagogue with the Jews and the devout persons, and in the marketplace every day with those who happened to be there. 18 Some of the Epicurean and Stoic philosophers also conversed with him. And some said, “What does this babbler wish to say?” Others said, “He seems to be a preacher of foreign divinities”—because he was preaching Jesus and the resurrection. 19 And they took him and brought him to the Areopagus, saying, “May we know what this new teaching is that you are presenting? 20 For you bring some strange things to our ears. We wish to know therefore what these things mean.” 21 Now all the Athenians and the foreigners who lived there would spend their time in nothing except telling or hearing something new. ------------------ 5 Core Values of SWAT 1. God s Word 2. Prayer 3. Evangelism 4. Discipleship 5. Community ------------------ https://swatradio.com/ SWAT - Spiritual Warriors Advancing Truth Call us Toll-Free at: +1-844-777-7928 Email Us a Question: ask@swatradio.com FIND A SWAT MEETING Woody s Bar-B-Que 226 Solano Rd Ponte Vedra, FL 10611 Wed. 6:30-7:30 am IHOP 3250 Hodges Blvd Jacksonville, FL 32224 Wed. Night 7-8 pm Salem Centre 7235 Bonneval Rd Jacksonville, FL Wed. 12:00-1:00 pm Jumping Jax House of Food 10131 San Jose Blvd #12 Jacksonville, FL Thursday 6:30-7:30 am The Village Inn 900 Ponce De Leon Blvd St. Augustine, FL Friday 9:00-10:30 am Woodmen Valley Chapel - Woodmen Heights Campus 8292 Woodman Valley View Colorado Springs CO 80908 Thursdays 8-9:15 pm

The market for smartwatches, wristband fitness monitors, smart rings and other wearable health trackers is booming. But could these devices and the data they capture actually transform healthcare? In this episode, we size up the potential of wearables to generate medical breakthroughs and even change how healthcare is delivered. We explore with Tom Hale, chief executive of Oura Health, and wearable tech researchers Jessilyn Dunn, Stephen Friend and Leo Wolansky. This episode is supported by Pictet Wealth Management and includes additional commentary from Alexandre Tavazzi, Pictet's head of CIO office and macro research. Hosted on Acast. See acast.com/privacy for more information.

[00:30] Hurricane Ian's Path of Destruction (28 minutes) Florida is reeling in the aftermath of Hurricane Ian, which left some coastal cities and towns totally destroyed. Despite the left's insistence that this hurricane was caused by climate change, the Bible reveals that God is the one who controls the weather. In Matthew 24, Jesus Christ prophesied that one of the signs of His imminent return would be an uptick in natural disasters. [28:50] When Republicans Come Under Attack the FBI Is Silent (13 minutes) Radical politicians and media personalities are calling for violence against MAGA Republicans. Ginni Thomas—wife of Supreme Court Justice Clarence Thomas—is being attacked by the media for saying she still believes the 2020 election was stolen. Meanwhile, 30 former FBI agents have expressed public support for FBI whistleblower Stephen Friend, voicing their own concerns about the politicization of the Bureau. [51:30] Age of Nuclear War (4 minutes) After Russian President Vladimir Putin's overt nuclear threats last week, some pundits are now talking about the world entering into a new age—the age of nuclear war.

There is no line between willing to stand for the Constitution and a willingness to risk it all for a Higher Good. In the end, they are the are the same, requiring equal amounts of courage, as exemplified by FBI whistleblower, Stephen Friend.

Pek Lum, co-founder, and CEO of Auransa believes that a lot fewer drugs would fail in Phase 2 clinical trials if they were tested on patients predisposed to respond. The problem is finding the sub-populations of likely high-responders in advance and matching them up with promising drug compounds. That’s Auransa's specialty.The Palo Alto, CA-based drug discovery startup, formerly known as Capella Biosciences, has a pipeline of novel compounds for treating cancer and other conditions identified through machine learning analysis of genomic data and other kinds of data. It’s closest to the clinical trial stage with a DNA-binding drug for liver cancer (AU-409) and is also working on drugs for prostate cancer and for protecting the heart against chemotherapy drugs. The company says it discovered AU-409 as part of a broad evaluation of data sets on a range of close to 30 diseases. The company’s discovery process uses a platform called the SMarTR Engine that uses hypothesis-free machine learning to identify druggable targets and compounds as well as likely high-responder patients. Lum  calls it “interrogating gene expression profiles to identify patient sub-populations.” The company believes this approach can identify unexpected connections between diverse molecular pathways to disease, and that it will lead to progress in drug development for intractable conditions with poorly understood biology, including cancer and autoimmune, metabolic, infectious, and neurological diseases.Lum co-founded Auransa with Viwat Visuthikraisee in 2014 and is the chief architect behind its technology. Before Auransa, she was VP of Product, VP of Solutions, and Chief Data Scientist at Ayasdi (now SymphonyAyasdiAI), a Stanford spinout known for building hypothesis-free machine learning models to detect patterns in business data. Before that, she spent 10 years as a scientific director at Rosetta Inpharmatics, a microarray and genomics company that was acquired by Merck. She has bachelor's and master's of science degrees in biochemistry from Hokkaido University in Japan and a Ph.D. in molecular biology from the University of Washington, where she studied yeast genetics.Please rate and review MoneyBall Medicine on Apple Podcasts! Here's how to do that from an iPhone, iPad, or iPod touch:• Launch the “Podcasts” app on your device. If you can’t find this app, swipe all the way to the left on your home screen until you’re on the Search page. Tap the search field at the top and type in “Podcasts.” Apple’s Podcasts app should show up in the search results.• Tap the Podcasts app icon, and after it opens, tap the Search field at the top, or the little magnifying glass icon in the lower right corner.• Type MoneyBall Medicine into the search field and press the Search button.• In the search results, click on the MoneyBall Medicine logo.• On the next page, scroll down until you see the Ratings & Reviews section. Below that, you’ll see five purple stars.• Tap the stars to rate the show.• Scroll down a little farther. You’ll see a purple link saying “Write a Review.”• On the next screen, you’ll see the stars again. You can tap them to leave a rating if you haven’t already.• In the Title field, type a summary for your review.• In the Review field, type your review.• When you’re finished, click Send.• That’s it, you’re done. Thanks!TRANSCRIPTHarry Glorikian: I’m Harry Glorikian, and this is MoneyBall Medicine, the interview podcast where we meet researchers, entrepreneurs, and physicians who are using the power of data to improve patient health and make healthcare delivery more efficient. You can think of each episode as a new chapter in the never-ending audio version of my 2017 book, MoneyBall Medicine: Thriving in the New Data-Driven Healthcare Market. If you like the show, please do us a favor and leave a rating and review at Apple Podcasts.For every drug candidate that makes it all the way through the three phases of clinical trials to win FDA approval, there are about 20 others that fail along the way. Phase 2, where drug makers have to prove that a new drug is safer or more effective than existing treatments, is where a lot of drugs falter.But often, it’s not because the drugs don’t work. Sometimes it’s just because they weren’t tested on the right patients. Meaning, the people in the treatment group didn’t happen have the right genes or gene expression profiles to respond. If you could find enough patients who were likely high-responders and try your new drug just on them, your chances of approval might go way up. The tough part is identifying those subpopulations in advance and matching them up with promising drug compounds.That’s where a company like Auransa comes in. It’s a Palo Alto startup that has built an AI platform called the SMarTR Engine. The engine uses public datasets on gene expression to identify subtypes of molecular diseases and predict what kinds of compounds might work against specific subtypes. Auransa used the engine to discover a drug for liver cancer that’s about to enter clinical trials. And it’s licensing out other drugs it discovered for prostate cancer and for protecting the heart against the effects of cancer chemotherapy.Some of the ideas baked into the SMarTR Engine come from a sub-field of artificial intelligence called hypothesis-free machine learning. And joining us this week to explain exactly what that means is our guest Pek Lum. She’s a biochemist and molecular biologist who worked at the microarray maker Rosetta Inpharmatics and the software company Ayasdi before founding Auransa in 2014. And she says one of the real revolutions in drug development is that almost every disease can be divided up into molecular subtypes that can best be treated using targeted drugs.Harry Glorikian: Pek, welcome to the show.Pek Lum: Thank you. Pleasure to be here.Harry Glorikian: You know, I always try to ask this opening question when I start the show to give the listeners a good idea of of what your company does. But you guys are in in drug discovery. What tell us how people understand what is the basic approach that you guys have. And I'll get into the special sauce later. But what do you guys do in the drug discovery space?Pek Lum: No, that's a really great question in the sense that when we first started in about five years ago, we... I've always been in the drug discovery field in the sense that I worked for over 20 years ago at that time in a company called Rosetta Inpharmatics, which is really pushing the cutting edge of thinking about using molecular data. Right. And to solve the mysteries of biology. And I was extremely lucky to be one of the core members in when we were very small. And then that really kind of put me in the sense put me in the stage where I could think about more than just one gene. Right. Because the technology was just kind of getting really kind of I would say not rolling forward, like propelling forward, with microarrays.Harry Glorikian: Yes.Pek Lum: So I was part of the whole movement and it was really amazing to be kind of like, you know, in the show as it runs, so to speak. And so and then Merck bought us after we went public and worked for Merck and Co. for another eight years, really learning how technology, how we should apply technology, how we can apply technology, molecular data, RNA data, DNA data to a drug discovery pipeline. And really kind of figured out that there are many things that the pharmaceutical world does very well, but there are many things that it also fails in and that how can we do it better? So I've always been in the mindset of, when starting Auransa with my co-founder, How do we do it better? And not only just do it better, but do it very differently so that we can address the most, I would say critical problems. So Auransa is really a company started by us to address the problem of why drugs actually fail a lot when we go into a Phase II efficacy trial. Right. Is not like the drug is bad or toxic. And most of the time is you can find enough responders to make your clinical trial a success.Pek Lum: And that cause, I guess, drugs actually made to maybe against one target. You don't really think about the biology that much at the beginning or the biology responders. So Auransa was really created to think about first, the heterogeneity of the disease and the heterogeneity of patient response. So we start from looking at molecular data of the disease from the get go. We take RNA, is really the RNA world is coming back with the vaccines.Harry Glorikian: Right.Pek Lum: And the RNA has always been fascinating because it tells you about the activity of the cell, of a normal cell versus a disease cell. So we use RNA transcriptomes right, transcriptomics to study the biology and the heterogeneity. So our algorithms, there are many algorithms, one of the first algorithms of the engine is really to look at the biology of heterogeneity, whether we can subdivide a disease into more homogeneous categories before doing anything.Harry Glorikian: Right. Yeah, I remember when, because when I was at Applied Biosystems, I remember Applied Biosystems, Affymetrix and then Stephen Friend starting this and like, you know, it was all starting back then. And I want to say we sort of had an idea of what we were doing, but compared to now, it's like, wow, how naive we were back then compared to how much this whole space has evolved. And it's interesting you mention, you know, RNA and its activity because in a couple of weeks, I'm actually going to be talking to a spatial genomics company so that you get a better idea from a visual standpoint of which cells are actually activating and which aren't.Harry Glorikian: But so, you've got an interesting professional career, and I say that because you were working at a big data analytics company for a while that was utilizing an approach that was hypothesis-free machine learning, where the machine was sort of identifying unique or aspects that you should be paying attention to. Maybe that it was seeing that instead of you going in there saying, let's just look over here, you could see what the machine was seeing for you. How much can you tell us a little bit about that experience? And then how did that influence what you're doing now? Because I have to believe that they superimpose at some level.Pek Lum: Right. I think, you know, ever since my first job at Rosetta and then my subsequent jobs really kind of culminated into this into this tech, as you see today. Right. All this experience and certainly experience while being a founding member of a small team at that time of Ayasdi, which is the software company, has been also an eye-opening experience for me because we were trying to create, using a very old mathematical idea called topology, or TDA, really start to figure out whether there's maybe there's some things that can't be learned. Right. And so typical machine learning methods need a training set or a test. But there are just some things where you don't really know what the ground truth is. So how do you do that? So that's the idea of like I say, the hypothesis-free approach. And the approach that that that the tech company, the software company that we built is really around the idea that not everything can be learned. But you can actually adapt some very interesting ideas around a hypothesis-free approach and then use it in a machine learning AI framework. So I definitely have been influenced by that thinking, you know, as I as we built the software.Harry Glorikian: Right.Pek Lum: And also, when we were Rosetta, we were generating in parallel, data on thousands of genes. And often at that time we were called, "Oh, you're just going fishing," you know, but fishing is not a bad idea because you don't really know which part of the ocean you need to go to catch your Blue Marlin, for example, right?Harry Glorikian: Yeah, no, no, absolutely.Pek Lum: Fish a little bit, not the whole ocean, but, you know, to get some, I would say, boundaries. Right. So in that sense, to me, a hypothesis-free approach gives you the boundaries where you can look. So, you know, so the experience, definitely the idea that you can use methods or thinking, algorithms, that could help you in a field where you do not know the ground truth. Like patient heterogeneity, I would say nobody really can pinpoint and say, OK, I can say that, oh, this is THE subtype, these are THE markers. And therefore, I'm going to go after this. And there are many. I guess, for example, you can think of a Herceptin as a great example, right, but when you first started, you know, it was like, wow, OK, you're going to go after a target. And then the idea of really kind of subtyping breast cancer, you know, I don't know, 20, 30 years ago. Right. And we're still learning about, you know, in a patient heterogeneity and we're just beginning to scratch the surface. So for Auransa, we wanted to use a method very much like the thinking that and the idea that we had, you know, when we were when I was at Ayasdi, is that you could search with some parameters, you know, a very complex space without needing to say, this is my hypothesis. This is that one gene, because we all know that if you have a target, you know ... to have to respond you need the target. But if you have the target, it doesn't mean you're going to respond. Because things below the target or above the target are much more complex than that.Harry Glorikian: Correct. And I always feel that there's, you know, I always call them low hanging fruit. Like the first one is, OK, well, it's either luck or skill, but I got to one level. But then you start to see people that are not responding. So that means something else is going on and there's subtypes. Right. So it's funny how we always also call it "rare diseases" in these smaller population. I'm pretty convinced that at some point everything is going to be a rare disease. Right. Because of the subtypes that we're going to start to see. I mean, even we're seeing in a neurological now, or Alzheimer's. There's subtypes of Alzheimer’s. No! Really? Shocking. Amazing to me that there's subtypes. Right. We've been dealing with this for ages. And I do believe that these technologies are so good at highlighting something where a human might not have seen it, might not have understood it. You know, I was I was interviewing actually I just posted it today on imaging and agriculture. And they were saying that sometimes the machine sees things that we don't fully understand how it sees it, but it sees it and points it out, which allows us now to dig into it and be able to sort of identify what that unique feature is that the machine has pulled out. I'm not sure I want drug discovery and drugs being based on something we don't fully understand, but the machine highlighting something for us that then we can go dig into, I think is an interesting greenfield space that that we need to explore more.Pek Lum: Right. I think you're absolutely right. You know, when we first started Auransa, that was the idea that we had. And then my co-founder and I thought, what if we find like hundreds of subtypes? We're never going to be able to make a drug again a hundred subtypes. So let's hope we find a small enough number of buckets that we can say this is approximately what it looks like, to be able to be practical to find drugs against those subtypes. So when we talk about subtypes, we are talking about you're absolutely right, it's like a leaf on a tree and that we have to cut it off at one point. Enough that things that, OK, this is homogeneous enough that actually makes sense out of it. And that's where the engine, that's what the engine does. Basically, it takes data, very, very complex data, things that we could never figure that out ourselves and say this approximately five, six buckets. So we've actually not found hundreds of subtypes, otherwise we probably would not have started Auransan, because it would have been impossible. But instead, we find n of one, but maybe a five to seven subtypes at most. That is enough for us to say, the machine says, OK, it is homogeneous enough, go for this. So that's kind of where we are, where we start at Auransa. And I think that's an important concept because people often thought about precision medicine as being, oh, I'm going to make a medicine for you and you only. But actually you could learn from, say, breast cancer, and that's approximately people with estrogen-receptor-positive tumors. And then you will likely respond to a drug like Tamoxifen. And even though we know that the response rate is only about, I think maybe 30, 40 percent. Right. But that's really good. At least at this poibt. So that's where we how we think about the engine as a shining light on a homogeneous enough population that we can actually make a drug against that.Harry Glorikian: Yeah. So that sort of leads us into you have this technology that you've termed SMarTR, S-M-A-R-T-R engine. Right. What does that stand for?Pek Lum: You know, that's my one of my rare occasion where I put my marketing hat on. I don't like marketing all. And we so and you notice the Mar is big-M, little-a-r. So S is for Subpopulation. Markers. Targets. And Redefining. Because I needed it to be Smartr.Harry Glorikian: Ok, ok. So and when you like when you've described this in the papers that I've looked at it, it's a machine learning mathematical statistical approaches, highly automated and totally runs in the cloud. So can you give us a little more color on the sort of the highly automated, and why is that so important?Pek Lum: Right. It's important because it comes from my own experience of working with, like, amazingly talented implementations and data scientist at the at Merck or I know how it goes where biologists will often ask them for something and they would run their magic and they'd give us an Excel sheet or a PowerPoint. Right. It's always a one-off one of those and one of that because you know, biologists are kind of one-off. So the idea of of us building this engine is not just equipping it with algorithms. So first of all, we don't have one algorithm, a hammer looking for a nail. We have a problem to solve. The problem is how to find novel drugs, drugs that people have never thought about, for patient populations that will respond.Pek Lum: So with that in mind, we built a pipeline of algorithms that starting from thinking about heterogeneity, to understanding preclinical models that reflect the biology of human subtypes, to predicting drugs and targets for those, and getting biomarkers for the patients when we go to the clinic. And we have different algorithms for each step of the pathway. So instead of having my team do a one-off thing, we know that if we don't do good software engineering it's going to be problematic because first it's going to take a really long time. This will be kind of higgledy piggledy in Excel sheets and we might be able to solve one thing. But to do this as a platform and as a pipeline builder, it would be impossible without good engineering practices. So we wanted to put this in, like I say, in a framework where everything is connected, so where it gets to run faster and faster through better algorithms, through better software engineering. And this really kind of came from my experience to at Ayasdi, a software engineering, a software firm. And also my co-founder who is a physicist and a software engineer, that we need to have good software practices. So what we did was we built first. We don't want any servers. Everything is done on AWS and is done in modules. So we create algorithms for each part of the pipeline, of the in silico pipeline. And then we have in such a way that when we take data in, when we ingest data, that we also automate it, and then by the time it ingest data and it spits out, I would say, what subtypes of disease, what biomarkers could be used in the clinic, what targets are interesting to you, what compounds from our digital library of compounds may be effective for that. Everything is more or less connected and could be done up in the cloud and now it finishes in about 24 hours.Harry Glorikian: When do humans look at it to say hmmm, makes sense. Or maybe we need to tweak the model a little. Right. Because it's not making sense. When does that happen?Pek Lum: So we, it happens at several steps. So within our engine we actually have benchmarks in there that we run periodically. You know, for example we have about about eight to ten data sets that we have for breast cancer, thousands of patient tumors. And we know approximately that it should be discovering, and it has discovered ER+ flavored subtypes, ERBB2, HER2+ subtypes, triple negative subtypes. So that is kind of like the rails that we put into our engine as well to make sure that when we actually do tweak an algorithm, it still has its wheels. But what we do is at this point, we generate out all the in-between data, but it's kept on the cloud. And once it's up, when it outputs the the list of things, the biologists actually, I would say the biologists with a knack for computation, we look at it and I myself look at it. I love to do data analysis in my spare time when I'm not doing CEO stuff. And we can see that we will look at once it's done that it also allows you...Ok, so this is an interesting one. The engine on the cloud outputs all of this. And right now, let's say my CSO, who is not a computational person, or me, or whoever really would be kind of a big pain to kind of go up and install the stuff and look at the things, some things you can't see. So what we did as a company is to build another kind of software, which is the visualization software on top of that.Pek Lum: So we have on our other end a visualization software that we call Polo because it's exploring that basically connects everything the SMarTR engine has done into something that's visualizable. It has a URL, we go to it and let's say, for example, my CSO wants to know, OK, the last one you did on head and neck cancer, you know, how many subtypes did you find? What is the biology, what's the pathway? And it could do all of that by him just going then looking at things. Or he can actually type in his favorite gene and then see what the favorite gene actually is predicted for how it behaves across over 30 diseases, and you can do that all at his fingertips, so we have that part of the engine as well, which is not the engine. We call it Polo, which is our visualization platform.Harry Glorikian: Right. It's funny because one of the first times I interviewed Berg Pharma and they were talking about their system, I was like, if you put on a pair of VR glasses, could you see the interconnectivity and be able to look in a spatial.... I was on another planet at the time, but it was a lot of fun sort of thinking about how you could visualize how these things interact to make it easy. Because human beings I mean, you see a picture. Somehow we're able to process a picture a lot faster than all this individual data. I think it... I just slow down. I rather look at a visual if it's possible.Pek Lum: It is so important because, you know, even though the engine is extremely powerful now, takes it 24 hours to finish from data input to kind of spitting out this information that we need. Visualization and also like the interpretation and just kind of making sure kind of like the human intelligence. Can I keep an eye on things. The visualization platform is so, so important. That's why I feel like that we did the right thing in making and taking time, putting a bit of resources to make this visualization platform for our preclinical team who actually then needs to look at it and go, OK, these are the drugs that are that are predicted by the engine. Can we actually have an analog of it or does it have development legs? Does it make sense? Does the biology makes sense. And so now we're basically connected everything. So you can click on a, you can find a drug in a database and it will pop up, you know, the structure and then it will tell you, hey, this one has a furan ring. So maybe you might want to be careful about that. This one has a reactive oxygen moiety. You might want to be careful about that. As we grew the visualization platform, we got feedback from the users. So we put more and more things in there, such that now it has a little visualization module that you can go to. And if you ever want to know something, I can just, I don't have to email my data scientist at 1:00 am in the morning saying, hey, can you send me that Excel sheet that has that that particular thing on it that I want to know from two weeks ago? I can just go to Auransa's Polo, right? As long as I have wi-fi. Right. And be able to be self-sufficient and look at things and then ask them questions if things look weird or, you know, talk to my CEO and say, hey, look at this. This is actually pretty interesting. And this one gets accessed by anybody in Auransa as long as you have Wi-Fi.Harry Glorikian: So so it's software development and drug development at the same time. Right. It's interesting because I always think to myself, if we ever, like, went back and thought about how to redo pharma, you'd probably tear apart the existing big pharma. Other than maybe the marketing group, right, marketing and sales group, you tear apart the rest of it and build it completely differently from the ground up? It was funny, I was talking to someone yesterday at a financial firm, a good friend of mine, and it's her new job and she's like, my job is to fully automate the back to the back end and the middle and go from 200 people down to 30 people because we're fully automating it. I'm like, well, that sounds really cool. I'm not really thrilled about losing the other 170 people. But with today's technology, you can make some of these processes much more automated and efficient. So where do you get your data sets that you feed your programs?Pek Lum: Yeah, let me tell you this. We are asked this a lot of times. And just kind of coming back again for my background as an RNA person. Right. One thing that I think NIH and CBI did really well over 20 years ago is to say, guys, now we no longer doing a one gene thing. We have microarrays and we're going to have sequencing. There's going to be a ton of data. We need to start a national database. Right. And it will enable, for anybody that publishes, to put the data into a coherent place. And even with big projects like TCGA, they need things that could be accessed. Right. So I think it is really cool that we have this kind of, I would say, repository. That unfortunately is not used by a lot of people because, you know, everything goes in. That's a ton of heterogeneity. So when we first started the company, before we even started the company, we thought about, OK, where is it that we can get data? We could spend billions of dollars generating data on cells, pristine data, but then it would never represent what's in the clinical trials without what's out there in the human the human world, which is the wild, wild west. Right. Heterogeneity is abundant. So we thought, aha, a repository like, you know, like GEO, the Gene Expression Omnibus, right, and ANBO or TCGA allows this kind of heterogeneity to come in and allows us the opportunity to actually use the algorithms which actually have algorithms that we look for. We actually use to look for heterogeneity and put them into homogeneity. These kind of data sets. So we love the public data sets. So because it's free, is generated by a ton of money. It is just sitting there and it's got heterogeneity like nobody's business. Like you could find a cohort of patients that came from India, a cohort of patients that came from North Carolina, and group of patients that came from Singapore and from different places in the US and different platforms. So because the algorithms at first that studied heterogeneity is actually, I would say, platform independent, platform agnostic, we don't use things that are done 20 years ago. They were done yesterday. And what we do is we look at each one of them individually and then we look for recurrent biological signals. So that's the idea behind looking for true signals, because people always say, you go fishing, you may be getting junk out. Right?Pek Lum: So let's say, for example, we go to, the engine points to a spot in the sea, in the ocean, and five people go, then you're always fishing out the same thing, the Blue Marlin, then you know that there is something there. So what we do is we take each data set, runs it through an engine and say these are the subtypes that I find. It does the same thing again in another data set and say these are the things that I find. And then it looks for recurrence signals, which is if you are a artifact that came from this one lab over here, or some kind of something that is unique to this other code over there, you can never find it to be recurrent. And that's a very weird, systematic bias, you know, so so because of that, we are able to then very quickly, I would say, get the wheat and throw away the chaff. Right. And basically by just looking by the engine, looking at looking for recurring signals. So public data sets is like a a treasure trove for Auransa because we can use it.Harry Glorikian: So you guys use your engine to I think you identified something unexpected, a correlation between plant-derived flavonoid compound and the heart. I think it was, you found that it helps mitigate toxic effects in a chemotherapy drug, you know. Can you say more about how the system figured that out, because that sounds not necessarily like a brand-new opportunity, but identifying something that works in a different way than what we thought originally.Pek Lum: Right, exactly. So in our digital library, let me explain a little bit about that. We have collected probably close to half a million gene expression profiles. So it's all RNA gene expression based, representing about 22,000 unique compounds. And these are things that we might generate ourselves or they are in the public domain. So any compound that has seen a live cell is fair game to our algorithms. So basically you put a compound, could be Merck's compound, could be a tool compound, could be a natural compound, could be a compound from somewhere. And it's put on a cell and gene expression was captured. And those are the profiles or the signatures that we gather. And then the idea is that, because remember, we have this part of the engine where we say we're going to take the biology and study it and then we're going to match it or we're going to look for compounds or targets. When you knock it down, who's gene expression actually goes the opposite way of the the disease. Now, this is a concept that is not new, right. In the sense that over 20 years ago, I think Rosetta probably was one of the first companies that say, look, if you have a compound that affects the living cell and it affects biology in a way that is the opposite of your disease, it's a good thing. Right thing. So that's the concept. But, you know, the idea then is to do this in such a way that you don't have to test thousands of compounds.Harry Glorikian: Right.Pek Lum: That is accurate enough for you to test a handful. And that's what we do. And by putting the heterogeneity concept together with this is something extremely novel and extremely important for the engine. And so with this kind of toxicity is actually an interesting story. We have a bunch of friends who are spun off a company from Stanford and they were building cardiomyocytes from IPS cells to print stem cells. And they wanted to do work with us, saying that why do we work together on a cool project? We were just starting out together and we thought about this project where it is a highly unmet medical need, even though chemotherapy works extremely well. Anthracyclines, it actually takes heart, takes a toll. There is toxicity and is it's a known fact. And there's only one drug in the market and a very old drug in the market today. And there is not much attention paid to this very critical aspect. So we thought we can marry the engine. At that time were starting up with oncology. We still we still are in oncology, and they were in cardiomyocytes. So we decided to tackle this extremely difficult biology where we say, what is a how does chemotherapy affect heart cells and what does the toxicity look like? So the engine took all kinds of data sets, heart failure data sets, its key stroke and cells that's been treated with anthracyclines. So a ton of data and look for homogeneity and signals of the of the toxicity.Pek Lum: So this is a little bit different from the disease biology, but it is studying toxicity. And we then ask the engine to find compounds that we have in our digital library, that says that what is the, I would say the biology of these compounds when they hit a living cell that goes the opposite way of the toxicity. And that's how we found, actually we gave the company probably about seven, I forget, maybe seven to 10 compounds to test. The one thing that's really great about our engine is that you don't have to test thousands of compounds and it's not a screen because you screened it in silico. And then it would choose a small number of compounds, usually not usually fewer than 30. And then we able to test and get at least a handful of those that are worth looking into and have what they call development legs. So this I would say this IPSC cardiomyocyte system is actually quite complex. You can imagine that to screen a drug that protects against, say, doxorubicin is going to be a pretty complicated screen that can probably very, very hard to do in a high throughput screen because you have to hit it with docs and then you have to hit it with the compounds you want to test and see whether it protects against a readout that is quite complex, like the beating heart.Pek Lum: And so we give them about, I think, seven to 10 and actually four of them came out to be positive. Pretty amazing. Out of the four, one of them, the engine, noticed that it belonged to a family of other compounds that looked like it. So so that was really another hint for the the developers to say, oh, the developers I mean, drug developers to say, this is interesting. So we tested then a whole bunch of compounds that look like it. And then one of them became the lead compound that we actually licensed to a a pharma company in China to develop it for the Chinese market first. We still have the worldwide rights to that. So that's how we tackled toxicity. And I think you might have read about another project with Genentech, actually, Roche. We have a poster together. And that is also the same idea, that if you can do that for cardio tox, perhaps you can do it for other kinds of toxicity. And one of them is actually GI tox, which is a very common toxicity. Some of them are rate limiting, you might have to pull a drug from clinical trials because there's too much GI tox or it could be rate limiting to that. So we are tackling the idea that you can use to use machine, our engine, to create drugs for an adjuvant for a disease, a life-saving drug that otherwise could not be used properly, for example. So that's kind of one way that we have to use the engine just starting from this little project that we did with the spin out, basically.Pek Lum: So basically, you're sort of, the engine is going in two directions. One is to identify new things, but one is to, I dare say, repurpose something for something that wasn't expected or wasn't known.Pek Lum: That is right. Because it doesn't really know. It doesn't read papers and know is it's a repurposed drug or something. You just put in it basically, you know, the gene expression profiles or patterns of all kinds of drugs. And then from there, as a company, we decided on two things. We want to be practical, right. And then we want to find novel things, things that, and it doesn't matter where that comes from, as long as the drug could be used to do something novel or something that nobody has ever thought of or it could help save lives, we go for it. However, you know, we could find something. We were lucky to find something like this flavanol that has never been in humans before. So it still qualifies as an NCE, actually, and because it's just a natural compound. So so in that sense, I would say maybe is not repurposing, but it's repositioning. I don't know from it being a natural compound to being something maybe useful for heart protection. Pek Lum: Now for our liver cancer compound, it is a total, totally brand-new compound. The initial compound that the engine found is actually a very, very old drug. But it was just a completely different thing and definitely not suitable for cancer patients the way it is delivered.Harry Glorikian: This is the AU 409?Pek Lum: Correct? Entirely new entity. New composition of matter. But the engine gave us the first lead, the first hit, and told us that we analyzed over a thousand liver tumors and probably over a thousand normal controls, found actually three subtypes, two of them the main subtypes and very interesting biology. And the engine predicted this compound that it thinks will work on both big subtypes. We thought this is interesting. But we look at the compound. You know, it's been in humans. It's been used. It's an old drug. But it could never be given to a cancer patient. And so and so our team, our preclinical development team basically took that and say, can we actually make this into a cancer drug? So we evaluated that and thought, yes, we can. So we can basically, we analogged it. It becomes a new chemical. Now it's water-soluble. We want to be given as a pill once a day for liver cancer patients. So so that's how we kind of, as each of the drug programs move forward, we make a decision, the humans make a decision, after the leadds us to that and say can we make it into a drug that can be given to patients?Harry Glorikian: So where does that program stand now? I mean, where is it in its process or its in its lifecycle?Pek Lum: Yeah, it's actually we are GMP manufacturing right now. It's already gone through a pre-IND meeting, so it's very exciting for us and it's got a superior toxicity profile. We think it's very well tolerated, let's put it that way. It could be very well tolerated. And it's it's at the the stage where we are in the GMP manufacturing phase, thinking about how to make that product and so on.Harry Glorikian: So that that begs the question of do you see the company as a standalone pharma company? Do you see it as a drug discovery partner that that works with somebody else? I'm you know, it's interesting because I've talked to other groups and they start out one place and then they they migrate someplace else. Right. Because they want the bigger opportunities. And so I'm wondering where you guys are.Pek Lum: Yeah, we've always wanted to be, I say we describe ourselves as a technology company, deep tech company with the killer app. And the killer app is drug discovery and development especially. And we've always thought about our company as a platform company, and we were never shy about partnering with others from the get go. So with our O18 our team, which is a cardioprotection drug, we out-licensed that really early, and it's found a home and now is being developed. And then we moved on to our liver cancer product, which we brought a little bit further. Now it's in GMP manufacturing. And we're actually looking for partners for that. And we have a prostate cancer compound in lead optimization that will probably pan out as well. So we see ourselves as being partners. Either we co-develop, or we out-license it and maybe one day, hopefully not too far in the future, we might bring one or two of our favorite ones into later stage clinical trials. But we are not shy about partnering at different stages. So we are going to be opportunistic because we really have a lot to offer. And also one thing that we've been talking to other partners, entrepreneurs, is that using our engine to form actually other companies, to really make sure the engine gets used and properly leveraged for other things that Auransa may not do because we just can't do everything.Harry Glorikian: No, that's impossible. And the conversation I have with entrepreneurs all the time, yes, I know you can do it all, but can we just pick one thing and get it across the finish line? And it also dramatically changes valuation, being able to get what I have people that tell me, you know, one of these days I have to see one of these A.I. systems get something out. And I always tell them, like, if you wait that long, you'll be too late.Harry Glorikian: So here's an interesting question, though. And jumping back to almost the beginning. The company was named Capella. And you change the name to Auransa.Pek Lum: That's right.Harry Glorikian: And so what's the story behind that? Gosh, you know.Harry Glorikian: When somebody woke up one morning and said, I don't like that name.Pek Lum: It's actually pretty funny. So we so we like to go to the Palo Alto foothills and watch the stars with the kids. And then one day we saw Capella. From afar, you look at it, it's actually one star. You look at closer, it's two stars. Then closer, it's four stars. It's pretty remarkable. And I thought, OK, we should name it Capella Biosciences. Thinking we are the only ones on the planet that are named. So we got Capella Biosciences and then probably, we never actually had a website yet. So we were just kind of chugging along early days and then we realized that there was a Capella Bioscience across the pond in the U.K. We said what? How can somebody be named Capella Bioscience without an S? So I actually called up the company and said, “Hey, we are like your twin across the pond. We're doing something a little different, actually completely different. But you are Capella Bioscience and I am Capella Biosciences. What should we do?” And they're like, “Well, we like the name.” We're like, “Well, we like it too.” So we kind of waited for a while. And but in the meantime, I started to think about a new name in case we need to change it. And then we realized that one day we were trying to buy a table, one of those cool tables that you can use as a ping pong table that also doubles as a as a conference room table. So we called up this New York City company and they said, oh, yeah, when are you going to launch the rockets into space. We're like what? So apparently, there's a Capella Space.Harry Glorikian: Yeah, OK.Pek Lum: Well, that's the last straw, because we get people tweeting about using our Twitter handle for something else. And so it's just a mess. So we've been thinking about this other name, and I thought this is a good name. Au means gold. And ansa is actually Latin for opportunity, which we found out. So we're like oh, golden opportunity. Golden answer. That kind of fits into the platform idea. Auransa sounds feminine. I like it. I'm female CEO. And I can get auransa.com. Nobody has Auransa. So that is how Auransa came to be.Harry Glorikian: Well, you got to love the…I love the Latin dictionary when I'm going through there and when I'm looking for names for a company, I've done that a number of times, so. Well, I can only wish you incredible success in your journey and what you're doing, it's such a fascinating area. I mean, I always have this dream that one day everybody is going to share all this data and we're going to move even faster. But I'm not holding my breath on that one when it comes to private companies. But it was great to talk to you. And I hope that we can continue the conversation in the future and watch the watch the progression of the company.Pek Lum: Thank you, Harry. This has been really fun.Harry Glorikian: That’s it for this week’s show. We’ve made more than 50 episodes of MoneyBall Medicine, and you can find all of them at glorikian.com under the tab “Podcast.” You can follow me on Twitter at hglorikian. If you like the show, please do us a favor and leave a rating and review at Apple Podcasts. Thanks, and we’ll be back soon with our next interview.  

We’re excited to present the full Shannon Luminary Series lecture by renowned cancer researcher Stephen Friend: “The Future of Human Agency: Exploration of the Role of Art and Technology in Determining Risk, Awareness, and Free Will.” Check out Episode 5 to hear why Bell Labs’ President Marcus Weldon called this “the bravest talk I’ve ever seen.” Also, you can watch the video of the lecture here: http://bit.ly/FriendsWarning. Future Human is a presentation of Nokia Bell Labs, produced by audiation.fm.

Revered cancer researcher Stephen Friend has a message: not only do we need to take more agency in our own healthcare, beyond the “priestly experts” we entrust, but we need to reclaim “endangered experiences” where we have a dialogue with ourselves. Bell Labs’ Marcus Weldon calls this lecture “the bravest talk I’ve ever seen.” Listen to this episode to understand why; then, listen to the full lecture in Episode 6. Future Human is a presentation of Nokia Bell Labs, produced by audiation.fm.

우리는 유전적 질환을 가지고 있는 사람을 보면서 무엇을 배울수 있을까요? 누가 그 질병에서 안전할까요? 유전적 질환을 가진 가족 중, 몇명만이 그 질병에 걸리고 다른 가족은 그 동일한 유전적 위험성을 피해 갑니다. 스티븐 프렌드는 우리가 건강하게 지내는 가족원들을 공부해야 한다고 제안합니다. 유전적 장애를 해독하는데 도움이될 유전물질을 수집하는, 큰 노력이 담긴 그의 회복 프로젝트에 대해 들어보세요.

Was können wir von den Menschen mit der Veranlagung zu Krankheiten lernen – wenn sie trotzdem gesund bleiben? Die meisten Erbkrankheiten brechen nur bei einigen Familienmitgliedern aus, während andere mit dem gleichen genetischen Risiko ungeschoren davon kommen. Stephen Friend schlägt vor, genau diese gesunden Familienmitglieder zu untersuchen. Erfahren Sie vom "Resilienz-Projekt", dem großen Vorhaben genetisches Material zu sammeln, das dabei helfen kann, vererbliche Krankheiten zu entschlüsseln.

¿Qué podemos aprender de las personas con la genética para enfermarse, que no lo hacen? Con la mayoría de las enfermedades hereditarias, solo algunos miembros de la familia desarrollan la enfermedad, mientras que otros, portadores del mismo riesgo genético, la evaden. Stephen Friend sugiere que empecemos a estudiar a aquellos miembros de la familia que se conservan sanos, y nos cuenta acerca del Proyecto Resiliencia, un esfuerzo masivo de recolección de material genético que puede ayudar a descodificar desórdenes hereditarios.

Que pouvons-nous apprendre des personnes ayant des prédispositions génétiques pour être malades et qui ne le sont pas ? En ce qui concerne la plupart des maladies héréditaires, seuls quelques membres de la famille vont développer la maladie, alors que d'autres, qui portent les mêmes risques génétiques, l'éviteront. Stephen Friend suggère que nous commencions à étudier les membres de la famille qui restent en bonne santé. Vous allez entendre parler du Projet Résilience, un effort massif pour collecter des matériaux génétiques qui pourrait aider à décoder les maladies héréditaires.

O que podemos aprender com as pessoas que deveriam adoecer por genética, mas que não adoecem? Na maioria dos casos de doenças hereditárias, somente alguns membros da família virão a desenvolver a doença, enquanto outros que carregam os mesmos riscos genéticos escapam. Stephen Friend nos aconselha a começar a estudar os membros da família que se mantêm saudáveis. Ele fala sobre o Projeto Resilience, um esforço massivo para coletar materiais genéticos que possam ajudar a decodificar distúrbios hereditários.

What can we learn from people with the genetics to get sick — who don't? With most inherited diseases, only some family members will develop the disease, while others who carry the same genetic risks dodge it. Stephen Friend suggests we start studying those family members who stay healthy. Hear about the Resilience Project, a massive effort to collect genetic materials that may help decode inherited disorders.