Podcasts about vasoconstriction

In this Huberman Lab Essentials episode, I discuss the critical role of temperature regulation in optimizing athletic and physical performance. I explain why overheating can hinder performance and endurance and how techniques like palmar cooling can help extend physical effort by aiding temperature regulation. I also highlight how specific body areas, such as the palms and face, are key targets for regulating temperature, allowing heat to dissipate efficiently. Lastly, I discuss how temperature can support training recovery while cautioning that extreme cold, such as ice baths immediately after training, can block adaptations. Huberman Lab Essentials are short episodes—approximately 30 minutes—focused on essential science and protocol takeaways from past Huberman Lab episodes. Essentials will be released every Thursday, and our full-length episodes will still be released every Monday. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Huberman Lab Essentials; Physical Performance & Skills, Temperature 00:03:03 Sponsor: AG1 00:04:07 Temperature Homeostasis, Vasoconstriction & Vasodilation 00:06:42 Elevated Heat & Performance Barrier 00:08:26 Regulating Temperature, Glabrous Skin, “AVAs” 00:12:20 Sponsor: Eight Sleep 00:13:49 Strength Training & Heat Effects, Tool: Palmar Cooling 00:17:21 Endurance, Temperature & Willpower 00:20:54 Tool: Resistance Training, Running, Palmar Cooling & Water Temperature 00:24:23 Sponsor: Function 00:26:09 Ice Bath & Blocking Training Adaptations; Tool: Glabrous Skin & Recovery 00:29:31 NSAIDs (Tylenol) & Training 00:31:56 Recap & Key Takeaways Disclaimer & Disclosures

My guest is Dr. Roger Seheult, M.D., a board-certified physician in internal medicine, pulmonary diseases, critical care, and sleep medicine at Loma Linda University. We discuss the powerful benefits of light therapy, including infrared light, red light, and sunlight, for improving mitochondrial function in all the body's organs. We also explore ways to reduce the risk of influenza, colds, and other illnesses that affect the lungs, sinuses, and gut. Topics include the flu shot, whether handwashing truly prevents illness transmission, and treatments for long COVID and mold toxicity. We review the efficacy of N-acetylcysteine (NAC), the power of hydrotherapy for combating infections, and strategies for improving sleep and overall health. Additionally, we discuss air quality. This episode provides actionable, science-based tools for preventing and treating infectious illnesses. Read the full show notes for this episode at hubermanlab.com. Sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Our Place: https://fromourplace.com/huberman Timestamps 00:00:00 Dr. Roger Seheult 00:02:16 Avoiding Sickness, Immune System, Tool: Pillars of Health, NEWSTART 00:08:03 Sponsors: Joovv & Eight Sleep 00:10:46 Sunlight, Mitochondria, Tool: Infrared Light & Melatonin 00:19:09 Melatonin Antioxidant, Reactive Oxygen Species (ROS)/Free Radicals 00:26:38 Infrared Light, Green Spaces, Health & Mortality 00:31:35 Infrared Light, Mitochondrial Dysfunction, Disease 00:38:46 Sunlight & Cancer Risk?, Tools: UV Light, Clothing & Sunlight Exposure 00:41:01 Sponsors: AG1 & LMNT 00:43:32 Sunlight, Incidence of Influenza or COVID 00:48:41 Tools: Sunlight Exposure Duration, Winter Months 00:55:18 Infrared Lamps?, Winter Sunlight Exposure; Obesity & Metabolic Dysfunction 00:59:48 Cloudy Days; Sunlight, Primitive Therapy, Hospitals 01:11:33 Sponsor: Function 01:13:21 Artificial Lights, Hospitals & Light Therapy?, ICU Psychosis 01:22:16 Sleep & Darkness, Tools: Eye Mask, Bathroom Navigation; Meals & Light 01:28:27 Influenza, Flu Shots, Swiss Cheese Model; Flu Shot Risks? 01:38:13 Masks?, Flu; Handwashing 01:42:16 Sponsor: Our Place 01:43:57 Water, Sodium; Innate Immune System, Fever & Hydrotherapy 01:53:46 Fever, Heat Hydrotherapy, Interferon & Immune System 01:58:25 Cold Hydrotherapy, Vasoconstriction & White Blood Cells 02:09:56 N-Acetyl Cysteine (NAC), Glutathione, White Clots, Flu, Covid 02:19:28 Tool: NAC Dose & Regimen; Mucous, Flu Symptoms 02:25:25 Zinc Supplementation, Copper; Exogenous Interferon 02:28:40 Eucalyptus Oil, Inhalation 02:32:22 Air, Smoking, Vaping, Nicotine Gum 02:36:49 Fresh Air, Forest Bathing, Tool: Go Outdoors 02:40:09 Nature vs Inside Environments, Dark Days/Bright Nights Problem 02:52:38 Long COVID, Mitochondrial Dysfunction, Intermittent Fasting, Sunlight 03:00:43 Covid & Varied Severity, Smell Loss Recovery 03:05:04 Mold Toxicity, Lungs, Germ vs Terrain Theory, Immunocompromised 03:11:46 Trust, Spirituality, Community, Faith; Forgiveness 03:19:46 Hospital Admission, Tool: Asking Questions 03:25:42 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures

In this episode, my guest is Dr. Teo Soleymani, M.D., a double-board-certified dermatologist and specialist in skin cancer and reconstructive surgery. We discuss science and clinically supported protocols to improve skin health and give your skin a more youthful appearance and structure, reducing premature aging and skin cancer risk. We discuss the impact of sun exposure on skin appearance and aging and the surprising relationship between sun exposure and skin cancer. We explain how mineral-based (inorganic) sunscreens differ from chemical (organic) sunscreens, whether sunscreen can minimize premature skin aging, reduce cancer risk, and if there are any health risks associated with sunscreen use. We discuss skincare routines to significantly improve skin appearance and how to select skincare products. We discuss how caffeine, nicotine, alcohol, and stress impact the skin and describe how nutrition and anti-inflammatory diets can improve skin health. We also discuss the causes and treatments for common skin conditions, including dandruff, acne, rosacea, eczema, psoriasis, and vitiligo. Our conversation also covers topics such as the use of retinoids, laser treatments, red-light phototherapy, supplements, and how to best monitor for skin cancer. This episode provides numerous actionable protocols, most of which are zero-to-low cost, for improving skin health and appearance, reducing cancer risk, and treating skin problems. Access the full show notes for this episode at hubermanlab.com. Pre-order Andrew's new book, Protocols, at protocolsbook.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman ROKA: https://roka.com/huberman Joovv: https://joovv.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Teo Soleymani 00:01:35 Sponsors: ROKA, Joovv & Helix Sleep 00:05:45 Skin Turnover; Skin Appearance & Stress  00:13:35 Caffeine, Vasoconstriction & Skin Redness 00:16:31 Nicotine, Vaping & Skin Appearance 00:18:37 Alcohol, Skin Health 00:24:33 Hydration, Fluid Intake & Genetics 00:26:19 Tool: Selecting a Moisturizer 00:29:28 Sponsor: AG1 00:30:40 Puffiness Under Eyes & Cause 00:32:14 Tool: Skin Cleansing; Frequency, Showers 00:41:57 Dry & Flaky Scalp, Dandruff 00:46:09 Cost & Skincare Products 00:50:20 Tool: Sun Exposure & Skin Health, Mood 00:56:24 Sponsor: LMNT 00:57:35 Sunscreens vs. Sunblocks; Mineral-Based (Inorganic) vs. Chemical (Organic) Sunscreen 01:02:45 Physical Barriers, Sunscreens, Oral Supplements & Skin Cancer 01:07:27 Skin Cancer, Genetics; Sunscreen, Premature Aging 01:12:11 Premature Aging & Skincare 00:15:56 Choose Mineral or Chemical Sunscreen? 01:20:24 Polypodium Supplement, Sun Exposure, Skin Redness 01:26:02 Tool: Selecting Mineral-Based Sunscreens 01:28:30 Chemical Sunscreens & Blood-Brain Barrier 01:30:13 Nutrition, Gut Microbiome & Skin Health 01:34:28 Tool: Nutrition for Skin Health, Protein, Anti-Inflammatory; Collagen; Omega-3 01:42:58 Retinoids vs. Retinol, Skin Appearance 01:49:45 Laser Resurfacing; Exfoliation, Microdermabrasion 01:56:52 Red Light Therapy & Phototherapy, Face Masks, Light Panels 02:04:10 Psoriasis, Phototherapy 02:10:03 Vitiligo, Immune System & Skin Cancer Risk 02:15:41 Acne, High Glycemic Index Foods, Dairy 02:19:38 Rosacea, Types & Treatments 02:23:00 Eczema, Immune System 02:25:37 Popping Pimples & Acne Scars; Corticosteroids 02:30:15 Tattoos; Tool: Monitoring for Skin Cancer, Moles, Annual Exams 02:36:28 HPV, Cancer & Warts; Vaccine & Cancer Risk 02:43:31 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures

The facts about scalp cooling Claire Paxman, the brand ambassador & Director of global education for Paxman scalp cooling, the global leader in scalp cooling.Claire shares how it was her Mum having breast cancer in the 90's that first made her aware of scalp cooling, when she tried the cold cap. Her Mum went on to lose her battle with cancer at just 44. She was 14 when she had to shave all her Mum's hair off, which was a devastating experience for her.Her Grandfather invented the first ice bank cooler for beer, and they began to use their knowledge of cooling systems to develop a better scalp cooling system which is a medical device. Vasoconstriction can have a great effect on how much hair is lost during chemotherapy treatment, and also how fast it will grow back.Claire shares how knowledge & education around the use of the cold cap is vital, and is working hard to ensure that the correct information is given and available to hospitals and patients.Connect with Claire:InstagramWebsite Hair & Scalp Salon Specialist course Support the Show.Connect with Hair therapy: Facebook Instagram Twitter Clubhouse- @Hair.Therapy Donate towards the podcast Start your own podcastHair & Scalp Salon Specialist Course ~ Book now to become an expert!

In this episode of the Critical Oxygen podcast, Coach Aaron Geiser and I discuss various recovery tactics beyond sleep and nutrition. We explore the benefits of cold plunge therapy, including improved sleep and mental toughness. Heat therapy, such as saunas and hot baths, may also aid in recovery and heat acclimation. Massage therapy and trigger point therapy are effective in releasing tension and improving blood flow. We also explore recovery tactics that help athletes de-stress and increase blood flow to optimize performance. TAKEAWAYS 1) Recovery tactics beyond sleep and nutrition can aid in faster de-stressing and improved blood flow. 2) Cold plunge therapy can improve sleep, mental toughness, and circulation. 3) Heat therapy, such as saunas and hot baths, can aid in recovery and heat acclimation. 4) Massage therapy and trigger point therapy can release tension and improve blood flow. 5) Recovery tactics should focus on de-stressing and increasing blood flow. Enjoy! Enjoying these podcasts? Don't forget to subscribe to get notified when new episodes are released. If you have a question or topic you want us to address, leave a comment! Follow Phil on Instagram - https://www.instagram.com/criticalo2 Follow Aaron on Instagram - https://www.instagram.com/triageiser/ OUTLINE 00:00 Introduction 03:04 Moving Beyond Sleep and Nutrition 03:30 Cold Plunge Therapy 09:23 Duration and Benefits of Cold Plunge 13:03 Vasoconstriction and Vasodilation 15:26 Heat Therapy and Heat Acclimation 18:37 Massage Therapy 23:49 Trigger Point Therapy 26:27 Maintenance and Proactive Care 28:48 Identifying and Addressing Muscle Imbalances 31:12 Therapeutic Tools: TheraGun and Cupping 35:44 Shockwave Therapy 43:12 Regenerative Medicine: PRP and Stem Cell Injections 50:16 IV Therapy and Legal Considerations 54:11 Importance of Certified Supplements 55:37 Recovery Tactics for De-stressing and Increasing Blood Flow 56:35 Avoiding Shady Practices and Unfair Advantages 57:03 Engaging with the Audience and Conclusion

 Wim Hof is famous for withstanding extreme cold (iceman) and for his breathing techniques… Now I like to explain how and why his techniques are working and how we can substitute his techniques to get similar results much easier… Wim Hof's method has 3 components:1. Breathing2. Cold therapy3. Mind focus1. The breathing method I have explained in a previous Blog (Wim Hof's breathing method.)We do 30 power Breaths, Maximum breathing in and out and at the end, we breathe every air totally out and try not to breathe in for a longer time (target 3 minutes)…Again, we are doing the same two times more.I made first-round 1:52 seconds, third round 2:37 seconds retention time… The medical explanationWe have an automatic nervous system that does the breathing and all the function in our body. We differentiate between the Sympathetic and Parasympathetic…Sympathetic are  fight/flight system, Alarm, stress, breath in, increase blood pressure/heartbeat, tightening muscles…Parasympathetic… is the opposite of Sympathetic, or feed/breed & rest/digest, relax, heal, sex, breath out, lower blood pressure/heartbeat…If we breathe in and out relaxed, the time to breathe in and out is the same, and that balance our body and hormones.The Wim Hof breath method is forced, unbalanced, stressful, and unnatural…If we hold our breath for a longer time, our blood is through the power of breathing alkaline and that is very healthy. Our growth hormone level increases and so do the longevity genes… And that is what we want!2. Cold therapy, -  The Heart will beat like crazy…If we have an unhealthy heart, ask your doctor if you can do so. We can do the cold therapy easily at home and save energy…Shower only with cold water… or shower first warm and then cold. In the south, the water is too warm, so not cold enough… Put ice in the water… What does it do for us?That is extreme Stress…Blood pressure/heartbeat will increase extremely fast. Vasoconstriction.Our growth hormones level increases and so do the longevity genes. Is this kind of stress good for you?Short time physical stress is Normal.Adaptive. Healthy.Constructive.Reason to improve.And is necessary. And bad for us is the chronic stress!Because it is: Abnormal.Maladaptive.Destructive. Emotional (all the time the same pattern, it breaks us down).Habitual (pattern).Excess physical stress (if we do too much, it breaks us down).Unhealthy.3. Mind - FocusTo jump in that ice-water.It can kill you, because of this massive sensory shock. I have done so… First Sauna and then to jump in that cold ice-water, My body got so stiff… You can't think anymore, you get that focus to leave that ice water as fast as possible…  Benefits:Pattern interrupt emotional and physical, because of this huge shock.Hormonal bursts.Activate survival circuits. Short time activation of Adrenalin. And in the long term, our growth hormone level increases and so do the longevity genes.  Brain stimulation.Calm down.If you do like that and can do so… Do it!First, get for 30 seconds in that ice water (Brrrr…) and slowly increase the time to 15 minutes (Brrrrr, Brrrr, Brrrrr…). It is just as it is, a long time in the ice-water is not so beneficial… It is much better to do short times, many times in a row… Like with the sauna, heat the body up and then cool the body rapidly down… do 3 to 5 rounds. Instead of ice-water, jumping in the snow, snow is much easier. And with the snow, my body never got stiff… The Alternative ways to get the similar results to the Wim Hof methods: The best is Fasting (several days) for more growth hormones and longevity genes.Hyper interval training (HIIT) (see my blog: Make it in 1 Minute!) Is the best for the cardiovascular system… I do it every day.(For example, a HIIT workout using a stationary bike for 30 seconds of cycling as fast as possible with high resistance, followed by several minutes of slow, easy cycling with low resistance.)Hot/cold therapy done in a Sauna is fun, and easy to do with good benefits.The Wim Hof Breathing method is too stressful and has too little benefit… Even a hot/cold shower with alternative changing from hot to cold or just empty a bucket of ice-water over your head… (Brrr) I do it so… My Video: Alternatives to Wim Hof methods https://youtu.be/oDcqs8d_cNQMy Audio: https://divinesuccess.net/wp-content/uploads/2021/Podcast2/Alternatives-to-Wim-Hof-methods.mp3

Est-ce que c'est vrai que la douche froide est bonne pour la santé ?La douche froide est vantée dans bien des articles de journaux et sur les réseaux sociaux. Elle pourrait, soit-disant, améliorer l'efficacité du système immunitaire, ou encore améliorer la récupération des muscles après l'effort, et bien d'autres idées. Mais sont-elles réelles ? Vous le découvrirez après avoir écouté ce nouvel épisode de Science ou Fiction.

IronRadio is back with regular weekly epsiodes! This week a buffed-up Statler and Waldorf - uh, Lonnie and Phil - muse on the popularity of one-legged training, then turn a listener mail on energy drinks into a full discussion on how they have used pre-workout-type stimulants over the years. --------- Subscribe at Apple iTunes: https://podcasts.apple.com/us/podcast/nutritionradio-org/id1688282387  Podcast on Spotify: https://open.spotify.com/show/1ECHrnjxjn33DBNWgErPtp Subscribe to our YouTube backup: https://www.youtube.com/lonman07?sub_confirmation=1 Podcast on Amazon/ Audible: https://www.audible.com/pd/NutritionRadioorg-Podcast/B0BS8LFLLX?qid=1675812257&sr=1-1&ref=a_search_c3_lProduct_1_1&pf_rd_p=83218cca-c308-412f-bfcf-90198b687a2f&pf_rd_r=YKEZ8DX192TQF0CQV8KX&pageLoadId=u3x6bJ1 Podcast web site: https://sites.libsyn.com/455769/site Sister site: https://www.ironradio.org/ 

Hyperbaric Oxygen Therapy (HBOT) is a treatment in which a patient breathes air or varying amounts of oxygen while inside a pressurized chamber, the pressure being anything above 1 atmosphere. The healing power of oxygen is not something new. The use of hyperbaric therapy dates back nearly 350 years. The very first hyperbaric chamber was created in 1662 with the clinical use of hyperbaric oxygen therapy starting in the mid 1800s. During the 1960s, studies began to show a wide variety of beneficial uses for HBOT therapy. Today, there are over 150 internationally approved conditions for which hyperbaric oxygen therapy has been shown to be effective and beneficial. Under normal circumstances, oxygen is absorbed into circulation when we breathe and transported throughout the body only by red blood cells.  Under pressure, oxygen can be dissolved into all of the body's fluids, the plasma, the lymphatic system, the central nervous system fluids, and the bone. This allows us to dissolve, transport and deliver many more times the normal oxygen to our tissues and cells. It has long been known that healing many areas of the body cannot take place without appropriate oxygen levels in the tissue. In many cases, such as circulatory problems and non-healing wounds, adequate oxygen cannot easily reach the damaged area. Oxygen can be carried to areas where circulation is diminished or blocked. In this way, extra oxygen can reach the damaged tissues helping the body to support its own healing process. The increased oxygen enhances the ability of white blood cells to kill bacteria, reduces swelling and allows new blood vessels to grow more rapidly into the affected areas. Hyperbaric Oxygen Therapy is safe and effective and provides this extra oxygen absorption with minimal side effects. 10 PRIMARY BENEFITS OF HBOT Increased oxygen perfusion- (Immediate increase in free floating oxygen available for tissue use) Neovascularization- Angiogenesis (new blood vessel growth) Increased white blood cell function (improved neutrophil and macrophage activity) Nerve healing factors (increases in VegF, BDNF, HIF1) Wound healing Increased capacity for healing (PDGF, VegF, collagen production circulatory healing) Stem cell release (up to 8-fold increase in mesenchymal and CNS stem cells) Vasoconstriction (decrease edema and swelling from damaged tissues) Mitochondrial healing (increase in size, shape and number of mitochondria) Anti-inflammatory (reduction of inflammatory cytokines, increase in anti-inflammatory cytokines) Anti-microbial/microbiome balancing (reduction in anaerobic pathogens and increase in aerobic probiotics) This and more in this latest episode of The Doctor Dads Podcast

California has banned flavored nicotine, potentially changing the podcast around, talking about how people make reels, and more!   TIMESTAMPS: (0:00) Different ways to podcast (2:30) William Robins (3:50) Composer talk (7:00) Making reels (10:40) California flavored tobacco ban (14:15) Nicotine (21:40) Vasoconstriction, vasodilation, & Nitric oxide (22:30) Relationship with health (28:30) Arab meals (30:30) Outro   SPONSORS: EKSTER: Get the highest quality smart wallet on the market for up to 30% off using code 2AM in combination with this link here: https://shop.ekster.com/2ampodcast   FOLLOW THE 2AM PODCAST: ALL PLATFORMS

Of course, you'd rather train inside when it's cold outside (right?), but sometimes you can't avoid it. Jeff and Jinger explain the physiological effects of training in the cold and share their top tips for training when the temperature drops. From cold habituation to keeping warm and staying properly fuelled, you'll get the Knowledge you need for effective cold-weather rides.**Learn more:**https://www.wahoofitness.com/blog/how-to-get-and-keep-that-winter-motivation/**Try the SYSTM Training App free for 14 days.**https://www.wahoofitness.com/systm/getting-startedHave questions? Please ask us here! https://wahoox.forum.wahoofitness.com/t/new-knowledge-episode-how-to-train-in-the-cold/20359

Dr. Santiago Ortega-Gutierrez discusses the risk of readmission following inpatient admission for reversible cerebral vasoconstriction syndrome. Show references: https://n.neurology.org/content/96/24/e2912

From icing ankle sprains to whole-body cryotherapy chambers, cold therapy has been a therapeutic procedure used for many years to resolve many issues. As scientific literature has increased, both excitement and skepticism for the effectiveness of the cold has increased. What hasn't changed, is the fact that cold exposure is often uncomfortable and undesirable. In this episode, you're going to learn why the discomfort of the cold is more than worthwhile. From improving brain performance and reducing neurodegenerative diseases to increasing fat burning potential and adding years to your life, forcing yourself to be cold has incredible powers. I'll also share my experience with daily cold showers, years of ice baths as an athlete, a regular cryotherapy practice, and most importantly, how you can begin to leverage the cold for an optimized life. Topics:[1:58] The cold activates mitochondria-rich brown adipose tissue[5:13] Sirtuins and the survival circuit[7:03] Vasoconstriction for better brain health[8:16] Relationship between the blood-brain barrier, the vagus nerve, and cold exposure[12:03] How cold showers have changed my life[14:17] Cryotherapy: Results of exposure to -180°C (-300°F)[15:44] Best and easiest ways to implement cold exposureFor more information, please visit:Website: https://learniiperform.com/Facebook: https://www.facebook.com//braedenostepchuk/Instagram: https://www.instagram.com/braedenostepchuk/Thank you all for joining me on this journey to lifelong health, happiness, and higher performance. And remember, always be grateful, love yourself, and serve others. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.27.357814v1?rss=1 Authors: Stankowska, D. L., Zhang, W., He, S., Krishnamoorthy, V. R., Harris, P., Hall, T., Chaphalkar, R. M., Kodati, B., Chavala, S. H., Krishnamoorthy, R. R. Abstract: Purpose: To determine if dietary administration of the dual ETA/ETB receptor antagonist, macitentan, could protect retinal ganglion cells (RGCs) following endothelin-1 (ET-1) mediated vasoconstriction in Brown Norway rats. Methods: Adult male and female Brown Norway rats were either untreated or treated with macitentan (5 mg/kg body weight) once a day for 3 days followed by intravitreal injection of either 4 l of 500 M ET-1 (2 nmole/eye) or vehicle in one eye. Imaging of the retinal vasculature using fluorescein angiography was carried out at various time points, including, 5, 10, 15, 25 and 30 minutes. Following the imaging of the vasculature, rats were either treated with macitentan (5 mg/kg/body weight in dietary gels) or untreated (control gels without medication). Following treatments, rats were euthanized, retinal flat mounts were prepared, immunostained for RGC marker Brn3a, imaged and surviving RGCs were counted in a masked manner. Results: Vasoconstrictive effects following intravitreal ET-1 injection were greatly reduced in rats administered with macitentan in the diet prior to the ET-1 administration. ET-1 intravitreal injection produced a 31% loss of RGCs which was significantly reduced in macitentan-treated rats. Following ET-1 administration, GFAP immunostaining was increased in the ganglion cell layer as well as in the retrolaminar region, suggestive of astrocytic activation by ET-1 administration. RGC numbers in macitentan treated and ET-1 injected rats were similar to that observed in control retinas. Conclusions: ET-1-mediated neurodegeneration could occur through both vascular and cellular mechanisms. The endothelin receptor antagonist, macitentan, has neuroprotective effects in retinas of Brown Norway rats that occurs through different mechanisms, including, enhancement of RGC survival and reduction ET-1 mediated vasoconstriction. Copy rights belong to original authors. Visit the link for more info

Why Use Push Dose Pressors? To buy yourself some time with your super hypotensive patients!! Ensure your patient's perfusion status while you are trying to: intubate managing transient hypotension preparing a drip preparing a central line Know which medication to use based on clinical presentation of patient. Dr. Scott Weingart's Easy Push Dose Printout (It has photos!) Epinephrine alpha 1&2, beta 1&2 agonist = inopressor (Increase in myocardial contraction, heart rate, and peripheral vascular resistance) Epinephrine Push Dose Concentration 10mcg/mL (1:100,000) vs. cardiac dose (1:10,000) Onset Immediate - 1 minute Duration 5-10 minutes Dose 5-20mcg every 2-5 minutes (0.5-2mL)   Preparation Draw up 9mL of Normal Saline in an empty 10mL syringe (updated - see below) Attach a syringe and draw up 1mL of epinephrine from the pre-filled cardiac dose amp (Epinephrine 100mcg/mL) Shake a little, Place a label: Epinephrine 10mcg/mL Phenylephrine alpha 1 agonist = increase in peripheral vascular resistance Heart rate remains the same. Watch out for reflex bradycardia.   Phenyelphrine Push Dose Concentration 100mcg/mL   Onset Immediate - 1 minute Duration 10-20 minutes Dose 50-200mcg every 2-5 minutes (0.5-2mL)   Preparation Draw up 1mL of phenylephrine (10mg/mL concentration vial) Inject into NS 100mL bag Shake a little, Place a label: Phenylephrine 100mcg/mL Use as a drip or draw up in a syringe. Super Nerdy Receptor Information Beta Receptors Tissue Receptor Subtype Heart beta1 Adipose Tissue beta1, beta3? Vascular Smooth Muscle beta2 Airway Smooth Muscle beta2 Beta1 Agonist Increases contractile force & HR. Activation of beta1 receptors in the atria and ventricles but the ventricles are really effected - thus increasing myocardial contraction. HR increases because SA node, AV node and the His-Purkinjie system are activated.   Beta 2 Agonist Relaxes smooth muscles   Alpha1 & Alpha 2 Agonist Constriction of vascular smooth muscle. Myocardial Alpha 1 may have a positive inotropic effect. No clear understanding on Alpha 2 receptors at this moment. Epinephrine & NE has equal affinity to both alpha 1 and alpha 2 receptors.  However, Epinephrine has a higher affinity to beta 2 receptors. So effects are dose dependent. Initially will activate beta 2 receptors so relaxes vascular smooth muscle and decrease peripheral resistance, but at higher doses, epinephrine will also bind to alpha 1 receptors which is a potent vasoconstrictor and will dominate as epinephrine concentrations are higher.   Phenylephrine is a pure alpha 1 agonist. Vasoconstriction of both arterial and venous vessels. Great for someone who has tachycardia/tachyarrhythmia but also hypotensive. Can cause reflex bradycardia. Update 8/6/2017 "Concentration" used to differentiate final concentration versus dosing, to have clear language. Update 8/8/2017 Brought to my attention by Craig Button, RN - There have been reported cases of serious medication errors due to mixing medications using pre-filled saline flushes and not labeling them. Therefore, I am going to change the recommended preparation of mixing epinephrine push dose concentrations. The LAST thing I want is to hear about unlabeled saline flushes with epinephrine lying around, and/or causing harm to patients. These medications should be respected so PLEASE LABEL ALL PREPARATIONS!! Original text is here. Blog post has been updated above. Original Text: Epinephrine Push Dose Concentration Preparation Take a NS 10mL flush and squeeze out air bubbles and saline so 9mL remains Attach a syringe and draw up 1mL of epinephrine from the pre-filled cardiac dose amp (Epinephrine 100mcg/mL) Shake a little, Place a label: Epinephrine 10mcg/mL Now listen to the episode.... References: Scott Weingart. EMCrit Podcast 6 – Push-Dose Pressors. EMCrit Blog. Published on July 10, 2009. Accessed on August 3rd 2017. Available at [https://emcrit.

Jonathan Jaggar explains how trafficking of regulatory subunits fine-tunes the activity of BK channels in arterial myocytes to limit vasoconstriction.

C.R.Y.O. Philadelphia provides therapeutic recovery services for athletes and active adults, as well as health and wellness benefits to the general public. Whole Body Cryotherapy (WBC) is a revolutionary method of cold therapy involving 3 minutes of exposure to subzero temperatures ranging from -200 F to -250͖ F. During the three minute treatment, the exposure to subzero temperatures causes the skin’s cold receptors to stimulate the nervous system. The body perceives this sudden and extreme cold to be a life-threatening situation and activates a chain of powerful survival mechanisms involving the body’s most crucial systems. Vasoconstriction occurs and blood is redirected from the peripheral tissue to preserve the vital organs and maintain core temperature. When one re-enters a room-temperature environment, the blood immediately rushes back to the skin, blood circulation is naturally stimulated, and oxygenated blood is delivered back to the damaged tissue. As a result, any blood with inflammatory properties gets treated and relief from pain and discomfort begins. This was absolutly amazing. I wasn't sore from my back to back workouts. Cryo also improved my mood. I can't wait to go back! . 

Scott Earley explains how reactive oxygen species activate TRPA1 ion channels to trigger dilation of cerebral arteries.

Garrett Semmelink: ViolinDownload the FLAC or the OPUS.

Scott Early talks about a pressure-sensitive signaling pathway that maintains constant blood flow to the brain.

Background: The pathophysiological basis of reversible cerebral vasoconstriction syndrome is poorly understood but carotid artery dissection has been discussed as a rare possible cause. So far, only single cases of unilateral carotid artery dissection and reversible cerebral vasoconstriction syndrome have been reported. Case: Here, we describe the case of a 54-year old patient presenting to the emergency department with right hemiparesis, hypaesthesia and dysarthria. Furthermore, he reported two episodes of thunderclap headache after autosexual activity. Cerebral imaging showed ischaemic infarcts, slight cortical subarachnoid haemorrhage, bilateral carotid artery dissection and fluctuating intracranial vessel irregularities, compatible with reversible cerebral vasoconstriction syndrome. An extensive diagnostic work-up was normal. No typical trigger factors of reversible cerebral vasoconstriction syndrome could be found. The patient received intravenous heparin and the calcium channel blocker nimodipine. Follow-up imaging revealed no vessel irregularities, the left internal carotid artery was still occluded. Conclusion: This case supports the assumption that carotid artery dissection should be considered as a potential trigger of reversible cerebral vasoconstriction syndrome, possibly by altering sympathetic vascular tone.

Background: Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism of the lung that matches blood perfusion to alveolar ventilation to optimize gas exchange. Recently we have demonstrated that acute but not sustained HPV is critically dependent on the classical transient receptor potential 6 (TRPC6) channel. However, the mechanism of TRPC6 activation during acute HPV remains elusive. We hypothesize that a diacylglycerol (DAG)-dependent activation of TRPC6 regulates acute HPV. Methods: We investigated the effect of the DAG analog 1-oleoyl-2-acetyl-sn-glycerol (OAG) on normoxic vascular tone in isolated perfused and ventilated mouse lungs from TRPC6-deficient and wild-type mice. Moreover, the effects of OAG, the DAG kinase inhibitor R59949 and the phospholipase C inhibitor U73122 on the strength of HPV were investigated compared to those on non-hypoxia-induced vasoconstriction elicited by the thromboxane mimeticum U46619. Results: OAG increased normoxic vascular tone in lungs from wild-type mice, but not in lungs from TRPC6-deficient mice. Under conditions of repetitive hypoxic ventilation, OAG as well as R59949 dose-dependently attenuated the strength of acute HPV whereas U46619-induced vasoconstrictions were not reduced. Like OAG, R59949 mimicked HPV, since it induced a dose-dependent vasoconstriction during normoxic ventilation. In contrast, U73122, a blocker of DAG synthesis, inhibited acute HPV whereas U73343, the inactive form of U73122, had no effect on HPV. Conclusion: These findings support the conclusion that the TRPC6-dependency of acute HPV is induced via DAG.

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Introduction: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM). Materials and Methods: Two DM 0.25% formulations {[}ointment (DM-o) and fatty ointment (DM-fo, water-free); class III corticosteroids], the corresponding active ingredient-free vehicles and three comparators of different strength {[}clobetasol propionate 0.05% (CP 0.05%), fatty ointment, class IV; hydrocortisone (HC) 1%, fatty ointment, class I, and betamethasone (BM) 0.05%, fatty ointment, class III] were tested using the vasoconstriction assay. The degree of vasoconstriction (blanching) in the treatment field was compared to the one found in untreated control fields using chromametric measurements and clinical assessment. Results/Conclusion: DM-o 0.25%, DM-fo 0.25% and BM 0.05% showed similar vasoconstrictive potential, i.e., clear blanching. In fact, both DM preparations were proven to be non-inferior to BM 0.05%, while CP 0.05% was found a little less active. HC 1.0% and the DM vehicles showed no clear-cut vasoconstrictive effect. No adverse events related to the study medications were observed. Good topical bioavailability of both DM formulations was detected by chromametric measurement and clinical assessment. Copyright (C) 2008 S. Karger AG, Basel.

The linkage of vascular genes to specific functions will lead to a better understanding of cardiovascular pathophysiology. We developed an experimental model that enables the introduction of one or multiple gene(s) into vascular smooth muscle cells (VSMCs) of isolated resistance arteries. Exposure of the arteries to a green fluorescent protein (GFP)-encoding plasmid in combination with the transfectant Effectene(R) for 20 h resulted in the expression of GFP in virtually all VSMCs in the arterial wall at fully preserved vascular function. For functional validation of the model, plasmids encoding the specific RhoA inhibitors C3 transferase or N19RhoA were transfected. In subsequent functional tests, inhibition of RhoA-dependent constriction induced by sphingosine-1-phosphate was similar to that in arteries treated with exogenous C3 transferase protein or the Rho kinase inhibitor Y27632. Responses to norepinephrine remained unaffected. This novel transfection technique enables gene function to be assessed in direct conjunction with signalling pathways in vascular tissue and provides, therefore, a new tool for microvascular proteomics. Copyright (C) 2003 S. Karger AG, Basel.

Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9068/1/9068.pdf Messmer, Konrad; Habazettl, H.; Zwißler, Bernhard; Welte, M.

1. The vascular actions of atrial natriuretic factor (ANF) have been assessed with other vasoactive agents on the hepatic arterial and portal vascular beds of the anaesthetized dog. 2. Intra-arterial bolus injections of ANF (0.1-50 nmol) caused graded increases in hepatic arterial blood flow representing a vasodilatation of relatively short duration. Vasoconstriction was never observed. 3. The maximum increase in hepatic arterial blood was the same for ANF and isoprenaline (Iso) i.e. approximately 60-70% increase over control flow. 4. On a molar basis, ANF was less potent than Iso although over the higher dose range (10(-9)-10(-7) mol) its vasodilator activity exceeded that of the endogenous vasodilator adrenaline. 5. Intraportal bolus injections (1.0-50 nmol) of ANF did not alter portal inflow resistance since no changes in portal inflow pressure occurred when the portal circuit was perfused at constant inflow volume. 6. This differential action of ANF on the hepatic arterial and portal vascular beds may provide a change in total liver blood flow in favour of the arterial component. 7. ANF, by altering hepatic haemodynamics to favour formation of trans-sinusoidal fluid exchange, may provide a temporary expansion of the extravascular fluid reservoir to buffer any increased venous pressure. However, chronically elevated plasma levels of ANF would encourage the formation of ascitic fluid.