Podcasts about vasodilation

Send us a textIn this episode of The Autoimmune Reset, VJ explores the fascinating connection between blood pressure and autoimmune disease, focusing on how both high and low blood pressure can be influenced by chronic inflammation and immune dysfunction. We discuss key markers like hs-CRP, lipoprotein(a), and small dense LDL, which offer valuable insights into cardiovascular health in autoimmune conditions.You'll also learn how autoimmune diseases can disrupt adrenal function, particularly the production of aldosterone, a hormone critical for regulating blood pressure and electrolyte balance. VJ dives into how low aldosterone levels can lead to symptoms like dizziness, fatigue, and salt cravings, shedding light on why low blood pressure is often overlooked but equally significant.Finally, we share practical recommendations to support healthy blood pressure, including:•Anti-inflammatory dietary strategies,•Vasodilation techniques like boosting nitric oxide production,•Adrenal-supportive practices to promote balanced aldosterone levels.Tune in to gain a deeper understanding of how blood pressure ties into autoimmune health and actionable steps to support your cardiovascular system naturally.Want to join my new program, The Inflammation Reset, designed to help you tackle inflammation at its source and reclaim your health? You can learn more here.If you are ready for change, download your free copy of The Autoimmunity Recovery Plan here so you can get started.Or, if you prefer working together 1-2-1 or would like to explore functional testing, you can find all my services here. Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.

Commentary by Dr. Candice Silversides

Are you tired of constantly losing the battle against chronic pain? Then get the ultimate defense—the new Ultrasound Therapy Device for Pain Relief and Recovery from Pure Skincare Co.! Go to https://www.pureskincareco.com/products/ultrasonic-therapy-machine-for-pain-relief to find out more. PureSkinCareCo City: North Miami Beach Address: 1835 NE Miami Gardens Dr Website http://www.pureskincareco.com Phone +1 800 597 4194 Email support@pureskincareco.com

In this episode, I explore the science behind these castor oil packs and how ricinoleic acid, a key component of castor oil, enhances lymphocyte activity and improves liver enzymes. I also touch on their potential role in supporting the liver during biotoxin illness. It's a deep dive into the benefits of a simple yet potent natural remedy. Topics: 1. Introduction to Castor Oil Packs - CIRS / Biotoxin Illness - Brief overview of castor oil packs - Their accessibility and cost-effectiveness 2. The Basics of Castor Oil Packs - How to create and apply a castor oil pack - Materials needed for the process - Preparation steps and protecting the area 3. Transdermal Absorption and Circulation - Ricinoleic acid's properties for transdermal absorption - Vasodilation and the role of heat packs - How ricinoleic acid is transported in the bloodstream 4. Ricinoleic Acid's Effects on Liver Function - The liver's vascularization and blood supply - Interaction of ricinoleic acid with liver cells (hepatocytes) - Proposed mechanisms of ricinoleic acid on liver function 5. Research on Castor Oil Packs - Presentation of studies on the effects of castor oil packs - Impact on immune function and liver health - Discussion on proposed mechanisms vs. observed outcomes 6. Step-by-Step Guide for Using Castor Oil Packs - Materials required for creating and applying packs - Detailed steps for applying a castor oil pack - Frequency and timing recommendations - Importance of consulting a healthcare professional Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

In Part 2 of this wildly interesting conversation with David Horinek on The Red Light Report, we dive into the newest product that David and I have collaborated on for BioLight: BioBlue! A lot of people in the health, wellness and longevity spaces — especially those entrenched in the world of biohacking — are familiar with, or at least have heard of, methylene blue. This synthetic blue dye that is notoriously used in fish tanks is actually a game-changer for mitochondrial health... how crazy is that?! The cherry on top is that methylene blue is an extremely powerful synergist with red light therapy, as it embodies photodynamic properties. In essence, if you are implementing red light therapy into your health regimen, methylene blue is a simple way to boost and compound those countless benefits.That's where David and I came together and developed an innovative, enhanced version of methylene blue (MB). BioBlue was developed with hand-picked ingredients specifically to augment the mitochondrial health benefits, as well as elevate the photodynamic properties of MB, thereby delivering a one-of-a-kind enhanced MB product. During today's episode, David details the unique ingredients we added to BioBlue, why we chose them and what potential benefits they confer when combined with MB.Ultimately, BioBlue is a supreme methylene blue product that works as a standalone cellular energizer via boosting mitochondrial health or as an incredibly powerful red light therapy synergist that can be added to any RLT treatment. I hope you find this information about methylene blue and BioBlue as fascinating and exciting as I do. As always, learn lots and light up your health! - Key points: Horehound benefits for arteries and lungs: (1:43) BioBlue: (3:46) Nitric oxide and methylene blue: (6:11) Vasodilation: (8:14) The free radical aging theory: (11:07) Nitric oxide is the primary driver of aging: (13:30) Testosterone: (19:53) Red light therapy and nitric oxide: (20:33) Methylene blue background: (21:21) Methylene blue effects on metabolism: (24:59) Methylene blue benefits listed: (26:48) What David saw while researching methylene blue: (29:09) Dr. Mike & David's new product, BioBlue: (35:06) HRV and combining methylene blue with red light therapy: (51:03) - Watch this episode on YouTube - Learn more about methylene blue and BioBlue: Benefits of methylene blueBioBlue - Be one of the first to get your hands on BioBlue! Save 15% on your pre-order by using coupon code: bioblue15 — this discount is valid for ordering single vials, 2-packs and 4-packs! - Kindle version of Red Light Therapy Treatment Protocols eBook, 4th Edition - To learn more about red light therapy and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Dr. Mike's #1 recommendation for grounding products: Earthing.com - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Instagram YouTube Facebook

You know it's coming — that familiar pre-workout tingle. It creeps up your neck, sweeps across your face, and dances down your arms. Some people love it, and some don't. But have you ever stopped to wonder what causes that curious sensation? Is it a rash? A negative side effect? Do you have an allergy to pre-workout supplements? Or is there something beneficial about that pre-workout tingle or itch you feel a few minutes after drinking it? In this article, I'll explain what makes you feel flushed and itchy or what gives you the tingles. However, I won't get into whether you should regularly use pre-workout or energy drinks. I did cover whether teens should use pre-workout supplements in the past, but I'll get into the pros and cons of pre-workout supplements at another time. Vasodilation and Nitric Oxide: The Cause of the Pre-Workout Tingle Vasodilation, dilation of your blood vessels, causes the pre-workout tingle. As your blood vessels widen, they allow more blood, oxygen, and nutrients to reach your muscles. The relaxation of blood vessels is a normal and healthy response. You dilate and constrict your blood vessels to regulate blood flow, ensuring that every part of your body, from your brain to your muscles, gets the oxygen and nutrients it needs. Vasodilation plays a significant role during physical activity. When you exercise, your muscles need more oxygen to produce energy. At the heart of this process is a molecule called nitric oxide. Nitric oxide signals the smooth muscle in your blood vessels to relax, causing them to expand.Förstermann, U., & Sessa, W. C. (2012). Nitric oxide synthases: regulation and function. European heart journal, 33(7), 829-837. Nitric oxide also signals the blood vessels in your muscles to expand, increasing blood flow and allowing more oxygen to reach your working muscles. Various factors can reduce nitric oxide production, including aging, poor diet, lack of physical activity, and certain health conditions like diabetes and heart disease. When nitric oxide levels decrease, it can lead to a condition known as endothelial dysfunction.Toda, N., & Okamura, T. (2013). The pharmacology of nitric oxide in the peripheral nervous system of blood vessels. Pharmacological reviews, 55(2), 271-324. The endothelium is the inner lining of your blood vessels. It plays a critical role in maintaining vascular health. Endothelial dysfunction leads to vasoconstriction — the narrowing of blood vessels. This reduces blood flow, leading to high blood pressure and other cardiovascular issues.Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008). The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics. Nature Reviews Drug Discovery, 7(2), 156-167. So, even though vasodilators have become extremely popular in pre-workout supplements, they also play an essential role in maintaining cardiovascular health for those who've developed heart disease. Compounds That Trigger the Pre-Workout Tingle Today, beta-alanine is the most popular vasodilator for pre-workout supplements, but other vasodilators exist. I'll briefly explain each. Beta-Alanine Beta-alanine is a non-essential amino acid that, when ingested, combines with histidine to form carnosine. Carnosine acts as a buffer, delaying the onset of muscle fatigue and enhancing your performance. However, when beta-alanine binds to nerve receptors, it can cause a sensation known as paresthesia (par·es·the·si·a) — the infamous pre-workout tingle or a feeling like you're getting poked with pins and needles. A systematic review published in the journal Amino Acids examined 15 studies on beta-alanine. The authors found that beta-alanine supplementation improved performance in high-intensity exercises lasting 1-4 minutes by 2.85%.Hobson, R. M., Saunders, B., Ball, G., Harris, R. C., & Sale, C. (2012). Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino acids, 43(1), 25-37.

On this episode, I discuss isosorbide mononitrate pharmacology, adverse effects, and important drug interactions. Isosorbide mononitrate is a vasodilator that works by relaxing and widening the blood vessels (primarily veins) through nitric oxide action. This reduces the preload and oxygen demand on the heart. The primary use for isosorbide mononitrate is angina prevention. It is important to remember that it is NOT meant for acute relief of chest pain. Headache is a major adverse effect of isosorbide mononitrate and can be very bothersome for patients. Vasodilation is primarily responsible for this adverse effect. PDE-5 inhibitors are notorious for causing drug interactions with any nitrate medication. I discuss management strategies in this podcast episode.

In this podcast, Dr. Jon Cole - an emergency medicine physician with Hennepin Healthcare and medical director with Minnesota Poison Control Center and Samantha Lee, PharmD - managing director with Minnesota Poison Control Center discuss the poison control system - past and present; along with a disscusion around toxicology - the big, the bad, and the ugly. Enjoy the podcast. Objectives:Upon completion of this podcast, participants should be able to: Describe the purpose of the Minnesota Poison Control Center, and how it works. Name the most common call types coming into MN Poison Control Center. Summarize the management of toxicological exposures for APAP, bupropion and calcium channel blockers. CME credit is only offered to Ridgeview Providers & Allied Health staff for this podcast activity. After listening to the podcast, complete and submit the online evaluation form.  Upon successful completion of the evaluation, you will be e-mailed a certificate of completion within approximately 2 weeks. You may contact the accredited provider with questions regarding this program at Education@ridgeviewmedical.org. Click the link below, to complete the activity's evaluation. CME Evaluation (**If you are listening to the podcasts through iTunes on your laptop or desktop, it is not possible to link directly with the CME Evaluation for unclear reasons. We are trying to remedy this. You can, however, link to the survey through the Podcasts app on your Apple and other smart devices, as well as through Spotify, Stitcher and other podcast directory apps and on your computer browser at these websites. We apologize for the inconvenience.)  DISCLOSURE ANNOUNCEMENT  The information provided through this and all Ridgeview podcasts as well as any and all accompanying files, images, videos and documents is/are for CME/CE and other institutional learning and communication purposes only and is/are not meant to substitute for the independent medical judgment of a physician, healthcare provider or other healthcare personnel relative to diagnostic and treatment options of a specific patient's medical condition; and are property/rights of Ridgeview Medical Center & Clinics.  Any re-reproduction of any of the materials presented would be infringement of copyright laws.  It is Ridgeview's intent that any potential conflict should be identified openly so that the listeners may form their own judgments about the presentation with the full disclosure of the facts. It is not assumed any potential conflicts will have an adverse impact on these presentations. It remains for the audience to determine whether the speaker's outside interest may reflect a possible bias, either the exposition or the conclusions presented. Ridgeview's CME planning committee members and presenter(s) have disclosed they have no significant financial relationship with a pharmaceutical company and have disclosed that no conflict of interest exists with the presentation/educational event. Thank-you for listening to the podcast. SHOW NOTES:  *See the attachment for additional information.  HISTORY of MN POISON CONTROL CENTER TOXICOLOGYCalcium Channel Blockers - Diltiazem, Verapamil, Amlodipine - Causes bad distributive shock - Pulmonary edema is an issue - Norepinephrine infusion is recommended in setting of shock with high dose insulin simultaneously - "Red, white and blue" therapy for refractory Ca++ blocker overdose - Activated charcoal - not for all patients, give if patient not at risk of aspiration for potentially lethal ingestions Bupropion - Chemical structure similar to amphetamine and bath salts - Sympathomimetic effects (tachycardia, agitation, seizures, ultimately cardiogenic shock) - Treatment with benzodiazepines - usually high dose - may need intubation - Norepinephrine for cardiogenic shock - ECMO may be needed Sodium Nitrite - Salt used to cure meats - Internet suicide phenomenon - Effect: Life threatening methemoglobinemia (chocolate colored blood, pallor, low O2 sats) - Very rapid onset of symptoms - Methylene Blue use N-acetylcysteine (NAC) for acetaminophen poisoning - Transitioning from 3 bag Prescott regimen to a 2 bag regimen - Rumack-Matthew nomogram is the same Article Resources:Cole JB, Lee SC, Prekker ME, Kunzler NM, Considine KA, Driver BE, Puskarich MA, Olives TD. Vasodilation in patients with calcium channel blocker poisoning treated with high-dose insulin: a comparison of amlodipine versus non-dihydropyridines. Clin Toxicol (Phila). 2022 Nov;60(11):1205-1213. doi: 10.1080/15563650.2022.2131565. Epub 2022 Oct 25. PMID: 36282196.   Cole JB, Olives TD, Ulici A, Litell JM, Bangh SA, Arens AM, Puskarich MA, Prekker ME. Extracorporeal Membrane Oxygenation for Poisonings Reported to U.S. Poison Centers from 2000 to 2018: An Analysis of the National Poison Data System. Crit Care Med. 2020 Aug;48(8):1111-1119. doi: 10.1097/CCM.0000000000004401. PMID: 32697480. Coralic Z, Kapur J, Olson KR, Chamberlain JM, Overbeek D, Silbergleit R. Treatment of Toxin-Related Status Epilepticus With Levetiracetam, Fosphenytoin, or Valproate in Patients Enrolled in the Established Status Epilepticus Treatment Trial. Ann Emerg Med. 2022 Sep;80(3):194-202. doi: 10.1016/j.annemergmed.2022.04.020. Epub 2022 Jun 17. PMID: 35718575. Kline JA, Tomaszewski CA, Schroeder JD, Raymond RM. Insulin is a superior antidote for cardiovascular toxicity induced by verapamil in the anesthetized canine. J Pharmacol Exp Ther. 1993 Nov;267(2):744-50. PMID: 8246150.   Thanks to Dr. Jon Cole and Samantha Lee, PharmD for their knowledge and contribution to this podcast. Please check out the additional show notes for more information/resources.

All published abstracts can be found here AbstractsCategory 1: Amlodipine VasoplegiaAbstract 1: Vasodilation in patients with calcium channel blocker poisoning treated with high dose insulin: a comparison of amlodipine versus non-dihydropyridinesStudy of HDI on propranolol poisoned pigsStudy of Minnesota HDI protocolAbstract 2: Amlodipine anxiety: a 10-year review of amlodipine associated fatalitiesAbstract 3: Extracorporeal membrane oxygenation utilization for vasoplegic shock due to pediatric toxic ingestionsData of ECMO in poisoningCategory 2: XylazineAbstract 4: “Tranq dope” opioid overdose: clinical outcomes for emergency department patients with illicit opioid overdose adulterated with xylazineCategory 3: Case Reports with Terrifying Clinical ImplicationsAbstract 5: Recovery after poly-drug overdose despite blood flow imaging demonstrating no brain perfusionAbstract 6: Challenges in diagnosing an environmental cause of recurrent methemoglobinemiaAbstract 7: Acute thiamine deficiency as a complication of insulin euglycemic therapy for an amlodipine overdoseCategory 4: Comparative evidence, Prognostication, and TriageAbstract 8: Utility of pre four-hour iron concentration in predicting toxicologyAbstract 9: Andexanet alfa vs 4-factor prothrombin complex concentrate for intracranial hemorrhage at a level I trauma hospitalCategory 5: Rapid ReviewAbstract 10: Fentanyl and fentanyl analogue exposure among emergency personnel and first responders: a systematic reviewAbstract 11: Significance of falsely low creatinine values in diagnosing massive acetaminophen ingestionAbstract 12: Large dose intentional ciprofloxacin ingestion associated with false-positive urine immunoassay for oxycodone and fentanylAbstract 13: Don't make it a double?: a 20- year review of supratherapeutic amlodipine ingestions while on chronic therapyAbstract 14: Evaluation of pediatric lisdexamfetamine exposures reported to a statewide poison control systemAbstract 15: An assessment of the reliability of stated quantity in acute acetaminophen overdoses reported to a regional poison center

https://blog.priceplow.com/podcast/todd-spear-katie-emerson-nutrition21-075 In early November of 2022, the SupplySide West convention was held at Mandalay Bay in Las Vegas, showcasing the premiere ingredients and technology in the dietary supplement and functional food industries. As is tradition, Team PricePlow met with Team Nutrition21 to catch up in-person — Nutriton21 being the industry-leading developer and supplier of dietary supplement ingredients well-known for ingredients such as Nitrosigine, nooLVL, Chromax, and Velositol. Mike and Ben met with Todd Spear (Sports Nutrition Category Leader) and Katie Emerson (Manager of Scientific Affairs) to discuss the latest research and industry trends coming out of both the industry at large and Nutrition21's team. This was a fun, informative, and fast-paced conversation where you get to meet some of the personalities behind the brands. We cover all four of Nutrition21's ingredients listed above, discuss their research, potential opportunities, and the reasons these ingredients are important in today's dietary landscape. Show Notes: (0:00) – Opening (2:00) – Nitrosigine (3:15) – Nitrosigine and Cognitive Function (3:45) – nooLVL vs. Nitrosigine (5:30) – What is inositol? (7:00) – The problems with traditional L-arginine (8:30) – The big scoop craze (9:30) – Vasodilation and Lowering of Blood Pressure (10:30) – Testing ingredients on gamers (12:00) – Early experiences with Nitrosigine (15:00) – Nitrosigine Dosing (19:00) – The point of no return for pumps? (21:30) – A transition back to lower-cost pre-workouts (23:30) – The University of Arkansas Study (25:30) – Stick Packs and Sachets (26:30) – Comparing ingredients fairly and measuring them (29:45) – Any ingredients NOT to combine Nitrosigine / nooLVL with? (32:15) – Velositol (35:00) – Soil mineral levels are worse than ever – need to supplement (37:00) – Nutrient timing (42:00) – Looking at actual endpoints from Velositol use (44:15) – Velositol does even more than what's currently claimed (44:50) – Velositol and Collagen?! (49:00) – Velositol should be in protein bars! (50:00) – Appetite suppression from chromium? (52:00) – Body awareness and fitness/nutrition (55:00) – Bucking the age-old trends of bad nutritional advice (58:30) – What's next for Nutrition21?

The world of supplements is full of amazing - and dubious - claims. It can all be pretty confusing. So in this first of our four-part series, Mac and Jinger discuss the proven science behind Nitrate and Sodium Bicarbonate. You'll learn what they're good for, how and why to use them, and who can expect the most benefit from them. Oh — and why you might not want to use mouthwash before drinking that beet juice.

This is a bitesize episode of 'The insuleoin Podcast - Redefining Diabetes'. Each week we'll take a look back into the archive of episodes and get you to think and reflective once more about some of the things we've learned over the past few years. In this week's BITESIZE:Hot weather affecting your Blood Sugar. Dehydration. Vasodilation. To hear the full episode check out episode #29: How Temperature Affects Your Blood Sugar. Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

Do you know what peptides are and how they can help with hormone optimization?   Listen in as Dr. Tracy Gapin joins The Hormone Prescription Podcast to discuss peptide therapy for hormone and health optimization at midlife - for both men and women.   As we age, our hormones naturally decline. This can lead to a host of issues, including fatigue, weight gain, mood swings, and more. Peptide therapy can help optimize hormone levels, resulting in improved energy levels, better sleep, and a general feeling of well-being.   In this episode, you will learn: What peptides are and how they can help optimize hormone levels The benefits of peptide therapy for both men and women The best time to start peptide therapy How peptide therapy can help with weight loss, energy levels, and more If you're interested in learning more about peptide therapy and how it can help you feel your best in midlife, tune in now!   [1:00] My guest today is a little unusual for a guest on this podcast. Why? Because he specializes in men's health. Well, Dr. Kyrin, you're thinking, why are you having a doctor who specialize in men's health? Because for most women, we've got men in our lives who are important to us and it matters, but also in many areas, there's a lot of overlap and he's gonna be talking about peptides and how they can be used to help with hormone balance and health optimization at midlife and beyond. And maybe we'll have a little guy talk to because what woman couldn't use to know more about the men in her life and how they function and how to help them.   [01:58] So Dr. Gapin is a board certified urologist world renowned health and performance expert, and the founder of the Gapin Institute for high performance health and the men's telehealth startup on Novi health, kind of like the counterpart to the hormone club. I think that's super cool. He's a thought leader, a professional speaker and the author of the bestselling books, male 2.0 and codes of longevity. His passion and purpose is providing fortune 500 executives, entrepreneurs, and athletes, a personalized path to optimize health and performance. Welcome Dr. Gapin.   [03:15] Thanks so much appreciate being here.   [03:17] So super excited to get started. So you're an, a urologist by training, but you have evolved your training to provide a functional approach for men so that they can have high performance at midlife and beyond. And you've created, uh, telehealth startup too. So can you talk a little bit about your journey from mainstream corporate medicine to where you are now?   [03:41]  So I am a board certified urologist, a men's health expert. Um, I was in traditional, if you will, Western medicine, forgs 25 plus years, including training. And I hit a wall. I got to a point where, um, I had some health issues that really, uh, changed my life. I was incredibly fatigued. I couldn't focus, couldn't sleep. I was about 30 pounds overweight and I knew something was wrong. And I went to see a, a local internal medicine doc here in town. And, uh, he ran some tests and, uh, the results were pretty terrible. And what really changed everything for me was he told me what I need to do was simply eat more vegetables. I need to lose some weight, exercise more. And if that doesn't work, maybe I'll be put on a statin, a prescription medication.    [04:29] And I left that day really confused because I knew I needed a lot more than that. And as a men's health expert, you would think that I would have the answers myself, but I didn't because I realized that at that point that we are failing, you know, traditional healthcare is all based on disease. We have disease care, crisis care, not healthcare. We are reactive simply waiting to treat illness or disease when it occurs rather than being proactive and intentional and, uh, focused on promoting health. And that's really what my book, Mel, 2.0 is all about, um, my sense for the gap Institute. That's what that's all about as well.    [05:21]  And you know, it's interesting when I work with women, I come from OB GYN background, exclusively work with women when they get better than the next question is, well, where do I send my, the men in my life, my husband, my partner, my son, the men in my life. And so this is why one of the reasons why I thought it would be great to have Dr. Gin on the show is because this is where you send them. . This is who you send them to, is the person who specializes in helping men.    [06:09] We would wear to a black tie dinner. And that was our reproductive capacity, our special superpower organs to make a baby in our hormones. But I learned from a functional approach that nothing could be further from the truth. And we really foundationally are very different. So I'm a fan of unique approach. Someone who specifically works with men and who knows them inside and out like Dr. Gapin and someone who knows women like I do. So that's my plug. But one of the things we're gonna focus on is peptides today. How did you become aware of the science of peptides and the power of peptides? What was that journey like?   [06:49] . I go see that doctor, you know, because of that experience. And so I think it's really important for the women in your audience to understand that, that you need to be advocates for your men because oftentimes men will not be proactive enough to take charge of their health and they'll simply wait for a problem. And typically that problem that will finally get them to see a doctor is issues with sex. And so don't wait for that to happen. Jump on it well before then, obviously. So that being said, um,   [07:49]  I did work with men at one point in the past decade, and you're I found that you're exactly right. You know, they wouldn't come cuz they're tired. They wouldn't come because they can't sleep, or they don't have their drive. But when they couldn't get an erection, that they would say, you know, something's wrong. And I, I would really, but I would find a lot of them were still hesitant to even have that conversation with doctors. So how can the women who are listed, who are in my audience, whose partners are having difficulty with erectile dysfunction, even get their partners to talk to doctors about that, how do they do that?   [08:33] So I'm going to give you 20 seconds of science here that I think is important to understand how an erection has increased blood flow to penis. What causes that a molecular level is increased nitric oxide secretion from the blood vessels that cause Vasodilation and increased blood flow. What affects nitric oxide production while most notably insulin resistance, insulin resistance blocks, nitric oxide production. So that's the correlation between metabolic issues in your body, your nutrition, your stress, your sleep, et cetera, which has a dramatic effect on your sex life. And so women recognize that if there's an issue with ed in your man, it could potentially be a sign of major underlying health issues that need to be checked out.   [09:40] Yeah. Like heart disease, heart attack. So super important. I always tell them when something's wrong below the belt, there's really something wrong above the belt and that could kill you. So you need to investigate that. All right. So now back to the peptides, when did that get on your radar? Yeah.   [09:57]  So when I recognize that our healthcare system is failing, that really sent me on a journey to learn, how can I really transform men's health? How can I reinvent the way we think about health and performance and longevity. And that's where I learned about functional medicine. I learned about epigenetics, which is, you know, the science of how our lifestyle and our genetics interact to affect our health, both good and bad. Um, I learned about hormone optimization and it's amazing that in medical school, in general surgery residency, in urology residency, I'm talking about 10 years of medical training before I actually went out there and hung my shingle up.    [10:44] And so I promise I'm getting to your peptide question and along my way here, you're fine. You know, when I think of health, I think of it like  a high performance bicycle wheel. You have the hub and that hub can be energy, weight, sex, cognitive focus, whatever it may be. And you have spokes coming out of that wheel. And each of those spokes are vitally important aspects of your health that are directly impacting that core function. That may be things like insulin resistance. I just mentioned, which is how your body handles glucose. It may be what you're eating when you're eating.   [11:29] It may be how your body handles toxins. It may be your sleep. It may be your stress. It may be hormones. And I want to emphasize not just testosterone. You know, men are so focused on testosterone, which certainly is important and levels are plummeting worldwide. We could talk about but there are other hormones that are critically important in men as well. You know, we have growth hormones. We have D H E cortisol insulin melatonin, vitamin D. It goes on, tThere are probably 15 hormones that we care about. Those are all different spokes of the wheel. And so coming back to this concept of cellular medicine, it's a systems approach to health. And so how do we impact all of the, the systems in your human body to achieve that outcome? And that's where peptides come in. Peptides allow us to, to specifically address things like inflammation at the cellular level, specifically impact immune function.   [12:17] We use peptides for specifically musculoskeletal repair. All of these different functions are working at a cellular level to impact what we're trying to accomplish. And so that's really the, the beauty of peptide therapy is that it allows a very precision based approach to health mm-hmm and they're not drugs. They're not pharmaceuticals. You know, peptides are nothing more than chains of amino acids. They're short proteins, and they're signaling molecules that our bodies already recognize. You know, as we age our levels of certain peptides decline and what we're doing with peptide therapy is really helping our body to restore those levels. So I'll give you a great example here.    [13:09] And there's a process involved there. And so we can stimulate our bodies to increased production of growth hormone, and that's gonna be amazing for helping things like sleep. One of the biggest complaints I hear with high performing men and women who I work with is trouble with sleep. It can help with weight loss. It could help with energy, with mood. It could help with metabolism, exercise capacity on and on and on growth. Hormone is a critical hormone that is often ignored. And so that's where we can really look at peptides to have a very precision based approach.   [13:37] So thank you for explaining that. I know some people, when they first hear about this concept of peptides that could help, and they're, they're told, oh, well they're basically amino acid that change their proteins. They say, oh, I don't need all that. I'm justgoing toa take a protein supplement or amino acid supplement or a collagen supplement. And my body's going to know what to do with it. So I don't need these fancy targeted things. What, what do you say to that?   [14:05] So when you're taking, you know, collagen, when you're doing protein, you know, weigh or P protein, whatever, you know, yeah. You're getting amino acids, but, uh, I want to be clear, a peptide has to be a very specific sequence taken in the exact right way for it to be effective. Mm-hmm . And so you're really talking apples and oranges that there's really no comparison. And the beauty of peptides comes down to it's non-pharmaceutical it is asuddenly sudden molecule that your body recognizes. the, the side effects are, are typically negligible and again, at a cellular level, amazing potential benefits.   [14:42] Mm-hmm so they're non-pharmaceutical but some of them require a prescription. Why is   [14:47] So there are numerous ways of getting peptides. You can get peptides over, you know, direct to consumers from these companies that are, uh, completely unregulated. It is the wild west out there. When, when you're looking at these and I, I would say that any place where a consumer, a non-physician can go purchase peptides, I would be very wary of it because the oversight of, and the, and the quality assurance at those places is truly questionable. And so when I prescribe, and I use the word carefully there to prescribe peptides for my patients, they come from compounding pharmacies, pharmacies that have oversight. They have quality assurance. They have to, um, have certificates of authenticity and, and they get tested regularly to be sure that you're actually getting what you're supposed to be getting. Um, and that's where I think a lot of people run into trouble where when you go over the counter, uh, direct to consumer you, you just don't know what the heck you're getting and you get side effects or issues, complications, or it doesn't work. And then you, you, you think that it was the pep tie when in fact it was purely just the, the source.   [15:48] Okay. So it, they, you need a prescription because they come from a compounding pharmacy, but it's not regulated by the FDA, but if you get one from a compounding pharmacy, you know that you're working with an organization that is regulated itself, so you should be getting a good quality. Correct?   [16:03] You're spot on, correct there. That it is, you know, peptides, they're not FDA approved because to clarify this for the FDA to approve something, it has to actually undergo clinical trials through the FDA. And that's what pharmaceutical companies do when they develop a drug for that drug to be sold. It has to go through that process. You'll never get that process to be done for a peptide because it's a by definition, generic product, because it is simply a chain of amino acids that any compounding pharmacy with the right equipment can produce manufacturer. And so it is therefore by definition, generic and the, the millions of dollars that are needed to produce these massive prospective, double blinded clinical trials to get a drug clear through the FDA. It's it's impossible.   [16:54] And so that's why my program my, my high level program is called N one performance health. And it's called N one, because everything we do is N of one medicine or N equals one medicine. And, and Kyrin, you, and I know what that means, but for the listeners, that means that everyone is uniquely different. And it's an individualized approach. Understanding, you know, at a cellular level, what things do, but that everyone's going to respond differently, and we have to really tailor individualized things. And so to that effect, a lot of the peptides we use are based on tons of science, don't get me wrong. We're not, we're not being cavalier. Mm-hmm , but they're not gonna, it's not possible for them to go through that FDA approval process.   [17:33] Yeah. Kind of like the bioidentical hormones   [17:37] Everyone loves to say, oh, they're not FDA approved. Well, estrogen is, and testosterone is, but when they compound it in this unique preparation that nobody's going to do that study. Yeah. So you mentioned, you   [17:50] Know, a comparison, I'm sorry to interrupt you. A co a comparison I would make is to say, well, vitamin D's not FDA approved. Well, it it's vitamin D it's generic. It's like, it's, it's, you can't approve, like, no one's going to do studies. It's just, that it's a hormone that we need. Vitamin D is in fact, a hormone, not a vitamin that we need. And so you don't need FDA approval to know that it is needed and how it works   [18:11] Is a great point. Yeah. Sorry, D is not FDA approved. Right. All right. So you mentioned growth hormone, which I, I think is super important. What are some of your other peptides that you might use to have various effects? What are some of the most powerful ones that you see at midlife that would be, that are important for men that are also important for women?   [18:33] That's actually very important as well when it comes to certain recent illnesses that we may have experienced. Right. And so I love them and alpha for improving boosting immune function, both men and women, you know, there are, are actual recent studies that came out, supporting its use for certain, um, illnesses that have been around lately. I love thy and alpha for immune function. Thy and beta is, uh, closely related. Uh, it is incredible when it comes to musculoskeletal repair, we're looking at tendons, ligaments, cartilage, bone. I just had elbow surgery and I am using thymus and beta for recovery for my elbow surgery, for example. So that's amazing. And again, boosting your body's ability to heal properly. This is not a pharmaceutical, again, it's a peptide with the, the amino acid sequences that are needed to, to achieve that specific outcome.   [19:52] And speaking of that recent illness that some people, a lot of us have had, I had it, you helped greatly. We were at a conference in, on the West Coast and one of our colleagues who didn't attend called us from Atlanta, and she was in a bad way, having thinking she had to go to the emergency room, and you actually talked with her and got her hooked up with certain peptides to help her. Yeah. And I mean, unfortunately she had a more severe case, but I really think she credits the peptides as really helping her.    [20:27] Yeah. Yeah. I got sick, uh, way back in March 2020, when everything first started, I was one of the first ones to get super sick that second week of, of March. And I took a combination of four different peptides that I'm sure had a dramatic effect on my recovery.   [20:40] Do you want to mention the thymus and alpha and beta part of that?   [20:44] Yeah. So th ayin, um, alpha is a great again, immune function Pepi that I really recommend.   [20:50] Yeah. Okay. Great. All right. So boosting immune system function, what are some of the others that you would say, oh, wow, everybody needs this. Cause like for women over 40 or 50, I say, you know, we all need our estrogen progesterone testosterone.   [21:05] n. So someone specifically focused on reducing inflammation, um, in the gut oral BPC is fantastic. I've had several patients who initially came to see me with nothing more than serious irritable bowel symptoms. And a month later they're on BPC, and they're completely fine. And I'm like, Hey Mike, how you doing with your gut? He's like, what do you mean? I'm like your gut stuff. And he completely forgot he even had it. And it was so pretty amazing how BBC cleared that up pretty quickly. BBC subq injection is also great for musculoskeletal or joint inflammation. So when we're looking at inflammation in the joint arthritis, injury, surgical repair, that sort of thing as well. So I love B BPC for inflammation, but again, there's not a peptide that I would recommend that every single person needs to be on.   [22:25] So having said that some people listening are thinking, well, how do I know which ones I need? Is it by symptoms? So is it like a symptom And then you get, like you said, joint inflammation, and then I need BPC subq, or is it based on laboratory findings? How does, how does somebody know?   [22:45] I think the answer is you work with a professional who is experienced at assessing patients from a functional perspective, understanding what's needed and prescribing the appropriate peptides. I can't tell you how often I'll have both men and women come in the office here and Hey, I really want this. I really want D S I to sleep deep sleep inducing peptide. For example, I really need, I heard about, I read about D S I, I really want to have that one, or I really want Mo SC, which is this mitochondrial biogenesis, peptide, uh, this or that. And when I actually talk to them and dive deeper into understanding their health issues, challenges, goals, that's not all what they actually need. And so I would caution against any, you know, person out there with, without medical experience, trying to go out and buying your own peptides. Peptides are amazing, but they should be really used in the context of a much bigger, more, you know, uh, systems approach to health.   [23:32] I like to emphasize, you know, a foundation of, you know, emphasis on fixing and correcting issues with sleep and stress and detox and hormones and nutrition and movement and mindset and breathing, all that stuff I think is critically important. And there's a tendency to fall back into that pill for every ill approach, with disease model medicine, and try to apply that same approach with peptides. And that's not how it works. You know, this is again, part of a systems approach to health. It's understanding how all the inputs to our human system are ultimately affecting that outcome. And peptides are great, but think of them as the icing on top of the cake.   [24:10]  Yes. Progress is impossible without change. And those who cannot change their minds cannot change anything from George Bernard Shaw. So really that's the hard work of health. Anyone can take a supplement, anyone can really follow any diet. Yeah. But doing the hard work of changing the way you're living your life. Has that been a factor for you in, in regaining your health? Did you find there were any thought or feeling patterns that you had to transform to optimize your health?   [25:14] Definitely. Yeah. Great question. So, you know, when I wrote my book, Mel, 2.0, you know, M a L E is actually an acronym for mindset, aging lifestyle and environment. And it's my system's approach to health. And it starts with M for mindset because until you fix that until you get your mind, uh, properly focused, you're never going to have success with everything else. And so I, I'm a huge advocate for mindfulness practices and uh, even meditation. That sort of stuff is wonderful. I also emphasize living with intention. And so every guy I work with, the first question I ask, one of the first questions I ask is what is your, why? Why are you doing this? And he'll say, well, I wanna lose 30 pounds. No, that that's. Excuse my language. You, you, you're not here cuz you wanna lose 30 pounds. What will that get you?   [26:01] And so if you only focus on these superficial things like weight loss, without focusing on the real, why then we're never gonna be successful. And so focusing on what is your why to me is really paramount. And then the next step is getting rid of limiting beliefs. And so like you were just alluding to most men have these thoughts that I'm too old to change. I'm set in my ways I can't change. This is how it is or the best one. I don't have time. I don't have time nonsense. That's nonsense. You don't have time. It's all about how do you schedule your day? What is your priorities? Again, it comes back to the three words that I emphasize living with intention.   [26:45] Yeah. I don't have time as code word first. I don't see the value in it. Really? Yes,   [26:51] We all get the same 24 hours in a day. We all have the same amount of time. You know, it's interesting. We were talking the other day with this specific group of women we're talking with now, uh, about blue zones and how one of the, the characteristics of the Arians in those communities was that they all had a life purpose that they could articulate. They had a why they had a why for why they do everything and what was important. And they lived with intention. So I had have given everyone the challenge to share their life purpose, be able to articulate it, everybody listening. I'm gonna invite you to do that too. Cuz you, you heard it also from Dr. Gin, that it's important. And you mentioned that your wife is amazing. I have to ask you about that. Cuz I know there's some women who are saying, oh, I want my husband to say that about me. What makes you say that about her?   [27:46] You know, I had a, I had a childhood with, with no real strong father figure. And so now for, for me, it's all about how can I be present and engaged with my family and, and give them what they need. And at the same time, I couldn't do that without my wife who is incredibly supportive and nurturing and loving and um, you know, we're a team and, and that's, you know, it should be easy. You know, one of my colleagues here, he's out there in the dating world, which I, I couldn't imagine being there again, but I gave him the, the guidance that it should be easy.   [28:24] . There's be times where, where you disagree with things, but it should still always be easy. And you're always in alignment, always in the same page. So I love the fact that we are a team. She's my best friend. And, and actually when I was filling out your form, I, I had to give you three quotes and the first two were easy. I say 'em every day and the throw one, like I need to throw a quote and, and she's Sarah sitting next to me. My wife's amazing. Yeah she is. And so I wrote that. So ,   [28:49] I love that. Well, let's share the other two too. You said, I believe there's nothing more than important than the quality of your life. And that starts and ends with your health. I couldn't agree more. And you also said you don't get today back, so make it count. Do you wanna say any more about all of these?   [29:06] Yeah. So the, the second one there, my brother-in-law John, he was this larger than life guy who everyone loved everywhere. He went, he was everyone's best friend and uh, loved him. He died of a heart attack at the age of 49 way too young. And we found out after the fact that he, although he looked like he was healthy, he was actually in fairly poor health for a while, but we never would've known, you know, what was striking about John was almost every day I saw him. He would say to me, Tracy, you don't get today. Back, make a count. He was that kind of positive, powerful person in my life. And when he passed at a very young age, it made that, that comment that he would always say that much more powerful and it still resonates with me today. Yeah. So that's that quote you don't get today back.   [29:51] So make account mm-hmm and then the, the first one, you know, I feel that we have a short time on this earth and we need to live life to its fullest and reach our full potential and to experience that you have to make your health, your top priority. And so often people don't. So often people are, again, back to the mindset part, not viewing it properly and not placing the emphasis where it needs to be. And so I believe that the quality of your life is important and you should be allowed to, and you should expect to have fun and enjoy life. But if you're not healthy, if you're not, well, you could never do that. So you gotta take care of that first. So that's what that's about.   [30:28] I could not agree more. And everybody listening, Dr. Gin is doing a wonderful little masterclass with women in my program. So as soon as we jump off the podcast interview, they're gonna get to have a private Q and a with him and really pick his brain about the men in their life and, um, how to help them to be their healthiest, which I think is super important. Like you mentioned earlier, women are the healthcare decision makers in their family. So it's, you know, I hate to say it, but we, we have a big responsibility to make sure that the men in our lives are getting what they made fair or not fair. It just is what it is. So we're gonna have chats about that as well, as more in depth on peptides and how the, we can get the icing on our cake with our health. So we'll be diving into that. Dr. Gapin, I keep saying it incorrectly. I apologize. How can people find out more? Where can they send the men in their lives? What resources, um, do you have for everybody?   [31:26] Sure thing. Yeah. So, um, my website is Dr. Tracy Gapin.com and, um, I have a couple free gifts if your audience would be interested,   [31:34] Please, if you wanna tell 'em about it, that's great. Absolutely. We will have links in the show notes, but feel free to talk about it. Yeah,   [31:40] So since we're talking about peptides, um, if you'll check out, um, my website for my center, which is gap institute.com, um, there, you can get a copy of my ultimate peptide guide, which will dive a lot deeper specifically into what we talked about today, Karen, about peptides and, and all the different peptides that we use that you could check out, uh, download from the site. But I'll also share the listeners if you wanted, uh, text health to 2 6, 7, 8, 6, and I'll put that number in the chat 2, 6, 7, 8, 6, uh, text the word health. What you'll get from there is a free copy of my secrets to high performance health guide. Cool. We'll also get a complimentary digital copy of my book mail 2.0, which I published, um, bestselling book a couple years ago. And if your men would like to get a, a complimentary discovery call with my team to understand how we can help them. Um, they're welcome to do that as well with the link that will be provided.   [32:35] Awesome. So they would use the text link.   [32:37] They'll be given a link. Exactly. That's right.   [32:39] Oh, okay. When they go there. Okay,   [32:40] Great. Yeah. Yeah. The text health is 2 7, 8, 6.   [32:43] Thank you for those amazing resources. I hope you continue to think that your wife is amazing and that she thinks the same of you. I love that. You know, I, I think that every great relationship is founded on great health. So congratulations to both of you for doing, doing the work and thank you for sharing, um, your wisdom and your journey with us. Thank you for sharing your passion for peptides and for root cause resolution medicine and health, and any last word you'd like to leave everyone with or any take action challenges.   [33:16] Yeah. I'm gonna give y'all one simple thing that everyone can do starting today that will actually make a amazing impact on your life. You may not even realize it, but how you breathe has a direct effect on performance, how you breathe, affects tissue oxygenation, which affects your brain, affects your ability to lose weight, your ability to build muscle, your exercise capacity and so on. And so I want you to think about breathing through your nose. One simple single change that you can make starting today right now is close your mouth. And I mean that in the most loving way possible break   [33:53] So true. So yes, continue to breathe through your nose as much as possible. Thank you so much Dr. Gapin for joining us today.   [34:02] And thank you all for joining us for another episode of the hormone prescription podcast with Dr. Kyrin. Hopefully you have learned something today that has inspired you, or maybe it's challenged you something that you're going to take action on. Don't let this just be information that goes in one ear and out the other, but ask yourself, how are you going to start to use this information to make changes in your life. Sometimes small steps lead to powerful impact. So I challenge you to do something different today, and I will talk to you next week when we'll have more hormone, fun and games until then peace, love and hormones. Y'all thank you so much for listening.   Get a copy of Dr. Gapin's 10 Secrets to High-Performance Health, a digital copy of his book, and a free discovery call with his team. Text Health to 26786  You may also visit his website: https://drtracygapin.com/   Join The Hormone Bliss Challenge  FEEL ENERGIZED, SEXY & CONFIDENT IN YOUR BODY AGAIN... IN JUST 5 DAYS. Discover How To Balance Your Hormones & Jumpstart Your Metabolism So That You Can Lose Weight & Regain Energy! CLICK HERE: https://bit.ly/hormonebalancebliss  

Huberman Lab Podcast Notes Key Takeaways Intermittent challenges or stressors to your system are good – humans are evolved for challenges, but today's lifestyle has taken away most of the common struggles we experienced beforeThree key nutrients for the brain and body: (1) sulforaphane; (2) omega-3; (3) vitamin DFood sources of sulforaphane: broccoli (barely cooked), broccoli sprouts, moringa powder“I personally think [omega-3 fish oil] is one of the most powerful anti-inflammatory things, dietary lifestyle things we can get easily that is going to powerfully modulate the way you think, the way you feel, and the way you age.” – Dr. Rhonda PatrickVitamin D is not just a vitamin! 70% of the US population is deficient – it's worth measuring & supplementing to optimal bone health, immunity, hormone conversion, and moreThere's a strong dose-dependent nature of sauna use: people who use sauna 4-7x/week have a lower risk (60% reduction) of dementia and Alzheimer's; people who use sauna 2-3x/week have a 20% reduction in riskHeat stress mimics moderate cardiovascular exercise effect – this could be a great onramp for people who are otherwise unable to exercise due to disability or whatever reasonThe cardiorespiratory system is improved in people who do both sauna and exercise compared to doing either aloneStress & memory: if you're too relaxed you won't remember things as well; at peak levels of stress, you remember things better until you reach too high a level of panic               Read the full notes @ podcastnotes.orgMy guest is Rhonda Patrick, Ph.D. She earned her doctoral degree in biomedical science from St. Jude Children's Research Hospital at the University of Tennessee Health Science Center and has become one of the leading public health educators on the brain and general health, aging, cancer, and nutrition. We discuss the four major categories of micronutrients that regulate cellular and organ stress and antioxidants, inflammation, hormone regulation, immune system, and longevity. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. Additionally, Dr. Patrick outlines protocols for deliberate cold and deliberate heat exposure to benefit metabolism, cardiorespiratory fitness, mental health, and lifespan.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Rhonda Patrick – Micronutrients, Cold & Heat Exposure  (00:03:12) Momentous Supplements (00:04:27) The Brain-Body Contract  (00:05:30) AG1 (Athletic Greens), Thesis, InsideTracker (00:09:42) Stress Response Pathways, Hormesis (00:16:38) Plants, Polyphenols, Sulforaphane (00:21:12) Tools 1: Sulforaphane - Broccoli Sprouts, Broccoli, Mustard Seed  (00:23:50) Tool 2: Moringa & Nrf2 Antioxidant Response (00:25:25) Sulforaphane: Antioxidants (Glutathione) & Air Pollution (Benzene Elimination)  (00:27:10) Plants & Stress Response Pathways, Intermittent Challenges  (00:29:35) Traumatic Brain Injury, Sulforaphane, Nrf2  (00:35:08) Tools 3: Omega-3 Fatty Acids (ALA, EPA & DHA), Fish Oil, Oxidation  (00:48:40) EPA Omega-3s & Depression  (00:52:02) Krill Oil vs. Fish Oil Supplements?  (00:54:23) Benefits of Omega-3 Fatty Acids, Omega-3 Index & Life Expectancy  (00:59:24) Tool 4: Food Sources of EPA Omega-3s  (01:06:07) Omega-3 Supplementation, Omega-3 Index Testing (01:10:22) Benefits of Omega-3s  (01:14:40) Tool 5: Food Sources of DHA Omega-3s (01:17:07) Vitamin D & Sun Skin Exposure  (01:22:18) Role of Vitamin D, Gene Regulation  (01:25:30) Tool 6: Vitamin D Testing & Vitamin D3 Supplementation  (01:33:15) Tool 7: Skin Surface Area & Sun Exposure, Vitamin D  (01:34:23) Vitamin D & Longevity (01:36:46) Sun Exposure & Sunscreen (01:40:30) Role of Magnesium, Magnesium Sources, Dark Leafy Green Vegetables (01:44:50) Tool 8: Magnesium Supplements: Citrate, Threonate, Malate, Bisglycinate  (01:50:57) Tool 9: Deliberate Cold Exposure Protocol & Mood/Anxiety (01:59:22) Tool 10: Cold Exposure, Mitochondria UCP1 & Heat Generation (02:02:30) Tool 11: Cold & Fat ‘Browning', PGC-1alpha, Metabolism (02:05:08) Cold Exposure & High-Intensity Interval Training (HIIT), PGC-1alpha, Muscle  (02:08:04) Tools 12: Exercise, HIIT, Tabata & Sauna  (02:13:30) Tool 13: Sauna, Endorphins/Dynorphins, Mood  (02:17:45) Tool 14: Mild Stress, Adrenaline & Memory (02:19:53) Sauna, Vasodilation & Alzheimer's and Dementia Risk  (02:25:30) Sauna Benefits, Cardiorespiratory Fitness, Heat Shock Proteins (HSPs)  (02:31:29) Insulin signaling, FOXO3 & Longevity  (02:33:22) Tools 16: Sauna Protocols, Hot Baths & Fertility  (02:37:41) Tool 17: Exercise & Longevity, Osteocalcin  (02:41:37) Tools 18: Red Light Sauna? Infrared Sauna? Sauna & Sweating of Heavy Metals (02:47:20) FoundMyFitness Podcast, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Huberman Lab on Instagram & Twitter Title Card Photo Credit: Mike Blabac Disclaimer

Huberman Lab Podcast Notes Key Takeaways Intermittent challenges or stressors to your system are good – humans are evolved for challenges, but today's lifestyle has taken away most of the common struggles we experienced beforeThree key nutrients for the brain and body: (1) sulforaphane; (2) omega-3; (3) vitamin DFood sources of sulforaphane: broccoli (barely cooked), broccoli sprouts, moringa powder“I personally think [omega-3 fish oil] is one of the most powerful anti-inflammatory things, dietary lifestyle things we can get easily that is going to powerfully modulate the way you think, the way you feel, and the way you age.” – Dr. Rhonda PatrickVitamin D is not just a vitamin! 70% of the US population is deficient – it's worth measuring & supplementing to optimal bone health, immunity, hormone conversion, and moreThere's a strong dose-dependent nature of sauna use: people who use sauna 4-7x/week have a lower risk (60% reduction) of dementia and Alzheimer's; people who use sauna 2-3x/week have a 20% reduction in riskHeat stress mimics moderate cardiovascular exercise effect – this could be a great onramp for people who are otherwise unable to exercise due to disability or whatever reasonThe cardiorespiratory system is improved in people who do both sauna and exercise compared to doing either aloneStress & memory: if you're too relaxed you won't remember things as well; at peak levels of stress, you remember things better until you reach too high a level of panic               Read the full notes @ podcastnotes.orgMy guest is Rhonda Patrick, Ph.D. She earned her doctoral degree in biomedical science from St. Jude Children's Research Hospital at the University of Tennessee Health Science Center and has become one of the leading public health educators on the brain and general health, aging, cancer, and nutrition. We discuss the four major categories of micronutrients that regulate cellular and organ stress and antioxidants, inflammation, hormone regulation, immune system, and longevity. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. Additionally, Dr. Patrick outlines protocols for deliberate cold and deliberate heat exposure to benefit metabolism, cardiorespiratory fitness, mental health, and lifespan.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Rhonda Patrick – Micronutrients, Cold & Heat Exposure  (00:03:12) Momentous Supplements (00:04:27) The Brain-Body Contract  (00:05:30) AG1 (Athletic Greens), Thesis, InsideTracker (00:09:42) Stress Response Pathways, Hormesis (00:16:38) Plants, Polyphenols, Sulforaphane (00:21:12) Tools 1: Sulforaphane - Broccoli Sprouts, Broccoli, Mustard Seed  (00:23:50) Tool 2: Moringa & Nrf2 Antioxidant Response (00:25:25) Sulforaphane: Antioxidants (Glutathione) & Air Pollution (Benzene Elimination)  (00:27:10) Plants & Stress Response Pathways, Intermittent Challenges  (00:29:35) Traumatic Brain Injury, Sulforaphane, Nrf2  (00:35:08) Tools 3: Omega-3 Fatty Acids (ALA, EPA & DHA), Fish Oil, Oxidation  (00:48:40) EPA Omega-3s & Depression  (00:52:02) Krill Oil vs. Fish Oil Supplements?  (00:54:23) Benefits of Omega-3 Fatty Acids, Omega-3 Index & Life Expectancy  (00:59:24) Tool 4: Food Sources of EPA Omega-3s  (01:06:07) Omega-3 Supplementation, Omega-3 Index Testing (01:10:22) Benefits of Omega-3s  (01:14:40) Tool 5: Food Sources of DHA Omega-3s (01:17:07) Vitamin D & Sun Skin Exposure  (01:22:18) Role of Vitamin D, Gene Regulation  (01:25:30) Tool 6: Vitamin D Testing & Vitamin D3 Supplementation  (01:33:15) Tool 7: Skin Surface Area & Sun Exposure, Vitamin D  (01:34:23) Vitamin D & Longevity (01:36:46) Sun Exposure & Sunscreen (01:40:30) Role of Magnesium, Magnesium Sources, Dark Leafy Green Vegetables (01:44:50) Tool 8: Magnesium Supplements: Citrate, Threonate, Malate, Bisglycinate  (01:50:57) Tool 9: Deliberate Cold Exposure Protocol & Mood/Anxiety (01:59:22) Tool 10: Cold Exposure, Mitochondria UCP1 & Heat Generation (02:02:30) Tool 11: Cold & Fat ‘Browning', PGC-1alpha, Metabolism (02:05:08) Cold Exposure & High-Intensity Interval Training (HIIT), PGC-1alpha, Muscle  (02:08:04) Tools 12: Exercise, HIIT, Tabata & Sauna  (02:13:30) Tool 13: Sauna, Endorphins/Dynorphins, Mood  (02:17:45) Tool 14: Mild Stress, Adrenaline & Memory (02:19:53) Sauna, Vasodilation & Alzheimer's and Dementia Risk  (02:25:30) Sauna Benefits, Cardiorespiratory Fitness, Heat Shock Proteins (HSPs)  (02:31:29) Insulin signaling, FOXO3 & Longevity  (02:33:22) Tools 16: Sauna Protocols, Hot Baths & Fertility  (02:37:41) Tool 17: Exercise & Longevity, Osteocalcin  (02:41:37) Tools 18: Red Light Sauna? Infrared Sauna? Sauna & Sweating of Heavy Metals (02:47:20) FoundMyFitness Podcast, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Huberman Lab on Instagram & Twitter Title Card Photo Credit: Mike Blabac Disclaimer

My guest is Rhonda Patrick, Ph.D. She earned her doctoral degree in biomedical science from St. Jude Children's Research Hospital at the University of Tennessee Health Science Center and has become one of the leading public health educators on the brain and general health, aging, cancer, and nutrition. We discuss the four major categories of micronutrients that regulate cellular and organ stress and antioxidants, inflammation, hormone regulation, immune system, and longevity. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. Additionally, Dr. Patrick outlines protocols for deliberate cold and deliberate heat exposure to benefit metabolism, cardiorespiratory fitness, mental health, and lifespan.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman See Andrew Huberman Live: The Brain Body Contract Tuesday, May 17th: Seattle, WA Wednesday, May 18th: Portland, OR https://hubermanlab.com/tour Our Patreon page https://www.patreon.com/andrewhuberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Rhonda Patrick – Micronutrients, Cold & Heat Exposure  (00:03:12) Momentous Supplements (00:04:27) The Brain-Body Contract  (00:05:30) AG1 (Athletic Greens), Thesis, InsideTracker (00:09:42) Stress Response Pathways, Hormesis (00:16:38) Plants, Polyphenols, Sulforaphane (00:21:12) Tools 1: Sulforaphane - Broccoli Sprouts, Broccoli, Mustard Seed  (00:23:50) Tool 2: Moringa & Nrf2 Antioxidant Response (00:25:25) Sulforaphane: Antioxidants (Glutathione) & Air Pollution (Benzene Elimination)  (00:27:10) Plants & Stress Response Pathways, Intermittent Challenges  (00:29:35) Traumatic Brain Injury, Sulforaphane, Nrf2  (00:35:08) Tools 3: Omega-3 Fatty Acids (ALA, EPA & DHA), Fish Oil, Oxidation  (00:48:40) EPA Omega-3s & Depression  (00:52:02) Krill Oil vs. Fish Oil Supplements?  (00:54:23) Benefits of Omega-3 Fatty Acids, Omega-3 Index & Life Expectancy  (00:59:24) Tool 4: Food Sources of EPA Omega-3s  (01:06:07) Omega-3 Supplementation, Omega-3 Index Testing (01:10:22) Benefits of Omega-3s  (01:14:40) Tool 5: Food Sources of DHA Omega-3s (01:17:07) Vitamin D & Sun Skin Exposure  (01:22:18) Role of Vitamin D, Gene Regulation  (01:25:30) Tool 6: Vitamin D Testing & Vitamin D3 Supplementation  (01:33:15) Tool 7: Skin Surface Area & Sun Exposure, Vitamin D  (01:34:23) Vitamin D & Longevity (01:36:46) Sun Exposure & Sunscreen (01:40:30) Role of Magnesium, Magnesium Sources, Dark Leafy Green Vegetables (01:44:50) Tool 8: Magnesium Supplements: Citrate, Threonate, Malate, Bisglycinate  (01:50:57) Tool 9: Deliberate Cold Exposure Protocol & Mood/Anxiety (01:59:22) Tool 10: Cold Exposure, Mitochondria UCP1 & Heat Generation (02:02:30) Tool 11: Cold & Fat ‘Browning', PGC-1alpha, Metabolism (02:05:08) Cold Exposure & High-Intensity Interval Training (HIIT), PGC-1alpha, Muscle  (02:08:04) Tools 12: Exercise, HIIT, Tabata & Sauna  (02:13:30) Tool 13: Sauna, Endorphins/Dynorphins, Mood  (02:17:45) Tool 14: Mild Stress, Adrenaline & Memory (02:19:53) Sauna, Vasodilation & Alzheimer's and Dementia Risk  (02:25:30) Sauna Benefits, Cardiorespiratory Fitness, Heat Shock Proteins (HSPs)  (02:31:29) Insulin signaling, FOXO3 & Longevity  (02:33:22) Tools 16: Sauna Protocols, Hot Baths & Fertility  (02:37:41) Tool 17: Exercise & Longevity, Osteocalcin  (02:41:37) Tools 18: Red Light Sauna? Infrared Sauna? Sauna & Sweating of Heavy Metals (02:47:20) FoundMyFitness Podcast, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Huberman Lab on Instagram & Twitter Title Card Photo Credit: Mike Blabac Disclaimer

Diet and exercise are the most common ways that we're told to treat heart health, but did you know that a chiropractor can also help improve the strength of your most important organ?  Today we'll explain how the heart and Atlas bone are connected and share some things we recommend for taking care of your heart.   Check us out on YouTube: https://www.youtube.com/channel/UCcsr5IZumEVg0QyCWVU0SRA    What we discuss in this episode:  0:56 – The importance of the Atlas bone 2:26 – Vasodilation 4:38 – Examples of how it works 5:23 – Medulla oblongota 6:07 – Study results 6:38 – Other ways to treat heart health 8:23 – Different types of fat 9:09 – How do we own our health 11:08 – What supplements can you use? 13:35 – Get checked   Read more and get additional resources here: http://aohealthpodcast.com 

Natural Way to Increase Blood Flow And Decrease Inflammation | Podcast #343 Schedule a FREE Consult: http://www.justinhealth.com/free-consultation Review us at: http://www.beyondwellnessradio.com/itunes Recommended products - Organic Grass Fed Meat: https://justinhealth.com/products/organic-grass-fed-meat B-Vitamin Synergy: https://justinhealth.com/products/b-vitamin-synergy Antioxidant Supreme: https://justinhealth.com/products/antioxidant-supreme Genova Organix® Comprehensive Profile: https://justinhealth.com/products/organix-comprehensive-profile Genova NutrEval® FMV: https://justinhealth.com/products/genova-nutreval-fmv Podcast Transcription: https://justinhealth.com/natural-way-to-increase-blood-flow-and-decrease-inflammation-podcast-343/ Get Show Updates Here: http://justinhealth.com/beyondwellness-newsletter You-tube Podcast Subscribe: http://www.youtube.com/subscription_center?add_user=justinhealth 1:57 - Inflammation and ways to reduce it 4:46 - Signs and symptoms of hypercoagulability 11:07 - Natural Herbs to improve blood circulation 16:47 Tips to improve blood circulation and reduce inflammation 20:06 - Food template, tests, and supplements For starters, blood flow is why your body can get what nutrients it needs and how it can eliminate what it doesn't. If you have reduced blood flow, your body will take longer to heal and recover. Reduced blood flow can often result in inflammation, pain, muscle cramps, fatigue, numbness or coldness in the hands and feet, digestive issues, and slower recovery time. According to Dr. J and Evan, there are three primary concerns to address when looking at improving circulation by reducing inflammation, blood viscosity (blood's stickiness or thickness), and supporting healthy arterial function (ensure the arteries can contract or dilate needed). So, how can food help us to do that? While the healthy foods we eat can benefit our blood flow and circulation, some foods are to be aware of as part of a healthy diet. Often, the additives we add to our food through sugars, trans fats, and salt can be tasty but with a few adverse side effects. ===================================== Subscribe on I-Tunes: http://www.beyondwellnessradio.com/itunes Review us at: http://www.beyondwellnessradio.com/itunes Visit us at: http://www.beyondwellnessradio.com Have a question: http://www.beyondwellnessradio.com/question

Age Ageing, Volume 48, Issue 6, November 2019, Pages 776–782 Biomedicines. 2020 Aug 6;8(8):277 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Are you looking for a bundle of Coach K's Top MSK Cheatsheets? Look no further: www.nptecheatsheets.com Helen presents with a T4 SCI and exhibits signs of autonomic dysreflexia. The therapist should anticipate which cardiovascular response: A. Hyperemia in the lower legs and feet B. Decreased blood pressure C. Vasodilation in the head, neck, and arms D. Increased heart rate Did you get this question wrong?! If you were stuck between two answers and selected the wrong one, then you need to visit www.NPTEPASS.com, to learn about the #1 solution to STOP getting stuck. --- Support this podcast: https://anchor.fm/thepthustle/support

Daniel Buitrago, Brandon Fifield, and Jack Lau float conversation on boater safety with Olivia Drown and Kosette Isakson   Boaters Safety, Life Jacket selection, Coho Rodeo, Heather's Choice, Inflatable LJ options,   Practice makes perfect, Mustang Suits, Drowning vs Hypothermia, Stages of cold water immersion 1) Cold Water Shock 2) Incapacitation 3) Hypothermia, Hypothermic Rescue, Throw Rope Practice, American Canoe Association, Swift Water Training, Alaskaboatersafety.org, Trivia, NASBLA, Departure Checklist, Novice to fill in Captain, Vasodilation, Wet waders and belts, Boating safety learning options, Alaska Water Wise, Cold Water Paddling, Alaska Boater Safety, Stay Calm, Pro Tips 1) Wear Life Vest 2) Carry Signaling Device 3) Share Float Plan 

Dr. Marc Cohen is one of the world's leading academics in the study of holistic and integrative medicine including sauna bathing, and in this podcast, guides me through a list of sauna protocols that can be used to achieve the most common sauna bathing health benefits. The sauna protocols he describes are designed from the findings and research from peer-reviewed studies conducted by Dr. Marc Cohen and his Ph.D. colleagues on longevity, the quality of life, and much more.

Full Notes ► http://bit.ly/FastingShowNotes Fasting = Physiological Rest & Rejuvenation 1. Gives the vital organs a complete rest. 2. Stops the intake of foods, emptying & rejuvenating the GI tract. 3. Promotes elimination of diseased tissue & cellular components. 4. Restores youthful condition & function throughout the body. 5. Clears & strengthens the mind. Fitness increases. Join the Sim Club for perks ► http://bit.ly/JoinSimMembership Our First Book ► https://highlevelperception.com SHOW NOTES

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.13.250209v1?rss=1 Authors: Barragan-Iglesias, P., De La Pena, J. B., Lou, T.-F., Loerch, S., Prakash, N., Shukla, T., Basavarajappa, L., Song, J., Megat, S., Moy, J., Wanghzou, A., Ray, P., Shepherd, J. D., Hoyt, K., Steward, O., Price, T. J., Campbell, Z. T. Abstract: Injury responses require communication between different cell types in the skin. Sensory neurons contribute to inflammation and can secrete signaling molecules that affect non-neuronal cells. Despite the pervasive role of translational regulation in nociception, the contribution of activity-dependent protein synthesis to neurogenic inflammation is not well understood. To address this problem, we examined the landscape of nascent translation in DRG neurons treated with inflammatory mediators using ribosome profiling. We identified the activity-dependent gene, Arc, as a target of privileged translation in vitro and in vivo. Inflammatory cues promote local translation of Arc in the skin. Arc deficient mice display exaggerated paw temperatures and vasodilation in response to an inflammatory challenge. Since Arc has recently been shown to be released from neurons in extracellular vesicles, we hypothesized that intercellular Arc signaling regulates the inflammatory response in skin. We found that the excessive thermal responses and vasodilation observed in Arc defective mice are rescued by injection of Arc-containing extracellular vesicles into the skin. Our findings suggest that activity-dependent production of Arc in afferent fibers regulates neurogenic inflammation through intercellular signaling. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.26.174227v1?rss=1 Authors: Sullender, C. T., Richards, L. M., He, F., Luan, L., Dunn, A. K. Abstract: Anesthetized animal models are used extensively during neurophysiological and behavioral studies despite systemic effects from anesthesia that undermine both accurate interpretation and translation to awake human physiology. In this paper, we characterize the impact of isoflurane on cerebral blood flow (CBF) during the induction of general anesthesia in awake mice using multi-exposure speckle imaging (MESI). We highlight the large anatomical changes caused by the vasodilatory inhalant with wide-field imagery and quantify the cortical hemodynamics with MESI across multiple subjects and imaging sessions. Compared to the awake state, we measured, on average, an 18% increase in surface vessel diameter accompanied by a 135% increase in vascular flux and 92% increase in parenchyma perfusion. These large alterations to the cortical vasculature and CBF are unrepresentative of normal physiology and provide further evidence that neuroscience experiments would benefit from transitioning to un-anesthetized awake animal models. Copy rights belong to original authors. Visit the link for more info

استمعوا للبودكاست الخاص بي " الاحياء الدقيقة في دقيقة" ارجو ان ينال اعجابكم . ادعموني على منصة patreon من خلال مساهماتكم على الرابط التالي www.patreon.com/microinmin #podcast #microbiology_in_aminute شرح ال Pathogenesis of 2019_nCoV : ١_ بعد دخول الفايروس الى الجسم، يحتاج الى مستقبل خاص (receptors) ليساعده على دخول الخلية، هذا ال receptor يسمى Angiotensin Converting Enzymes_2 إنزيمات الأنجيوتنسين المحولة يرمز له ب ACE_2 . ٢_ ال ACE_2 موجود على سطح خلايا الحويصلة الهوائية "alveolar cells" الموجودة في الرئة . لدينا ٣ أنواع من alveolar cells : _النوع الأول "type1" : يكون مسؤول عن تبادل الغازات مع الأوعية الدموية (gas exchange ). _النوع الثاني "type2" : يكون مسؤول عن إنتاج مادة ال "surfactant" و هو عبارة عن مزيج من البروتينات و الدهون التي تقلل الشد السطحي للحويصلة الهوائية. _النوع الثالث"type3" : خلايا مناعية "dust cell" و هي عبارة عن macrophages .البلاعم *ال ACE_2 موجود على النوع الثاني"type2" من هذه الخلايا. ٣_ غلاف فايروس كورونا يحتوي على بروتينات تسمى spikes.المسامير و خاصة (S_Spike) تساعد الفايروس على الارتباط ب ACE_2 . عندما يحدث الارتباط اعلاه، تدخل المادة الوراثية للفايروس الى داخل الخلية و تسخر الخلية لإنتاج بروتينات الفايروس و بالتالي يتكاثر الفايروس و تموت الخلية. ٤_ عندما تموت type 2 alveolar cells ف أنها تقوم ب طرح مواد تسمى specific inflammatory mediators وسطاء التهابات محددة هذه المواد تعمل على تحفيز الخلايا المناعية الموجودة "macrophages" و عندما تتحفز ال macrophages" ف أنها تفرز ٣ مواد مناعية تسمى ب " cytokines"السيتوكينات و هي: Interleukin_1 "IL_1"إنترلوكين Interleukin_6 "IL_6" Tumor Necrosis Factor "TNF_α" .عامل نخر الورم هذه المواد الثلاث عندما تصل الى مجرى الدم فإنها تسبب الاعراض المصاحبة للاصابة ب فايروس كورونا. #الأعراض: اولاً _ على مستوى ال lungs:الرئتين ١_ هذه المواد تسبب توسع بالاوعية الدموية المحيطة بالحويصلة و كذلك زيادة نفاذية جدار هذه الأوعية _ Vasodilation توسع الأوعية _ Capillary permeability increased .زيادة النفاذية الشعرية و بالتالي يؤدي الى "alveolar edema".الوذمة السنخية. التي تؤدي الى نقص الأوكسجين "Hypoxia"نقص الأكسجة و ضيق التنفس. ٢_ فقدان ال surfactant يؤدي الى زيادة الشد السطحي ل الحويصلة و بالتالي يؤدي إلى Alveolar collapse .انهيار سنخي. و تؤدي أيضاً الى Hypoxia و ضيق التنفس. ٣_ كذلك هذه المواد الثلاث تؤدي الى زيادة تدفق خلايا "neutrophils" الى مكان الإصابة الفايروسية ك استجابة مناعية، خلايا neutrophils تقوم بقتل بعض الفايروسات عن طريق إفراز مادتين مثل : _Reactive Oxygen Species "ROS". _ أنواع الأكسجين التفاعلية "ROS" _Proteases. البروتياز لكن المادتين أعلاه أيضاً تقوم ب تحطيم بعض ال alveolar cells المسؤولة عن التبادل الغازي وتسبب حالة تسمى consolidation الدمج. التي تسبب أعراض السعال "cough" . ثانياً: على مستوى ال CNS : الجهاز العصبي المركزي المواد الثلاث "IL_1, IL_6, TNF" تذهب الى ال "hypothalamus".الغدة النخامية. و بالتالي تعمل على زيادة درجة حرارة الجسم و تسبب أعراض ال "Fever" .الحمى ثالثاً: في حالة severe. شديدة. ستحدث ال " SIRS " Systemic inflammatory response syndrome . متلازمة الاستجابة الالتهابية الجهازية. التي تؤدي الى septic shock . الصدمة الإنتانية و كذلك "MODS" Multiple organ dysfunction syndrome. متلازمة ضعف الأعضاء المتعددة. و خاصة الكلية و بالتالي يحصل فشل كلوي.

https://www.body-furnace.com/ Wilbur licensed his invention Body Furnace to Brownmed, a leader in manufacturing products aimed at improving the quality of life for patients that has been in business for more than 50 years. In this interview with licensing expert and inventRight cofounder Stephen Key, they discuss how Wilbur developed and brought his invention to market. He started working on this project in 2003 because although he loved to hunt deer, he hated getting cold. He started trying to figure out ways to stay warm in his deer stand. He learned about how the body heats itself when your core temperature starts dropping. Brownmed further developed the product after licensing it from Wilbur. It uses reflective heat technology and has a low, medium, and high setting. Wilbur is proud of his accomplishment, as he should be! Go Wilbur! He also shouts the Inventors Center of Kansas City, which has been a huge help. In fact he met his licensee from an inventors group meeting. His next passion involves wind energy. Here's how it works: "Simply put, the Body Furnace heats the core, which frees your body to efficiently warm your extremities, including your hands, fingers, feet and toes. In other words, the Body Furnace works in conjunction with the natural function of the body to keep you warm. The human body has a certain amount of automatic temperature control, a process called thermoregulation, and attempts to maintain your body core temperature at 98.6°F. Your body has some flexibility; however, it is critical to maintain your bodily temperature within a very narrow range. Hypothermia sets in at just three degrees below our 98.6° baseline temperature. Your body produces heat for maintaining your core temperature by metabolizing food and muscle activity, this heat is lost through the skin and lung surfaces. When heat loss from a cold environment causes the core temperature to drop, the body's natural thermostat reacts with vasoconstriction, a restriction of blood flow to the extremities and skin surfaces. This is what's happening when you are feeling discomfort and pain in your hands and feet due to cold. Conversely, when heat is applied to the abdominal area, the core temperature rises causing a condition of vasodilation. Vasodilation expands the veins, allowing increased warm blood flow to reach the skin surfaces and extremities, relieving the discomfort of a cold environment. The Body Furnace heats the core to initiate this process of vasodilation, allowing your body to efficiently warm your extremities. Technically-speaking, the Body Furnace is a spot warmer that uses patented thermal reflective technology to concentrate heat on the abdominal area for effective deep penetration into the body core, leveraging the natural process of thermoregulation to send heat throughout the body via the circulatory system. This function is much like that of a home's central furnace." Bringing an invention to market? Let inventRight, the world's leading experts on product licensing, show you how. Co-founded by Stephen Key and Andrew Krauss in 1999, inventRight has since helped people from more than 60 countries license their ideas. Visit http://www.inventright.com for more information and to become their student. Call #1-800-701-7993 to set up an appointment with Andrew or another member of the inventRight team to discuss how we can help you license your ideas. New to licensing? Read inventRight cofounder Stephen Key's bestselling book “One Simple Idea: Turn Your Dreams Into a Licensing Goldmine While Letting Others Do the Work.” Find it here: http://amzn.to/1LGotjB. Want to learn how to license your product ideas without a patent? Stephen's book “Sell Your Ideas With or Without a Patent” explains exactly how. Find it here: http://amzn.to/1T1dOU2. inventRight, LLC. is not a law firm and does not provide legal, patent, trademark, or copyright advice. Please exercise caution when evaluating any information, including but not limited to business opportunities; links to news stories; links to services, products, or other websites. No endorsements are issued by inventRight, LLC., expressed or implied. Depiction of any trademarks/logos does not represent endorsement of inventRight, LLC, its services, or products by the trademark owner. All trademarks are registered trademarks of their respective companies.

THURSDAY THUNDER! Australian Muscle Weekly update with Kim & Adrian! This week the guys cover: 0:30 - Happy New Year 2:10 - Normality Resumes! 8:00 - Effects of Caffeine & Vasodilation 11:05 - Supplement News! 12:05 - ATP Science Gutright Challenge 14:10 - Super Saturday this Weekend! Check it out Here: https://youtu.be/378l3cV42UM Subscribe to Our Podcast! Apple Podcast Link: https://tinyurl.com/y8x36nt2 Android Podcast Link: https://tinyurl.com/ycxpny64 Contact us at: ausmuscle@adam.com.au Shop Online With Us Here: www.australianmuscle.com.au FREE Shipping on all orders Australia Wide! (NO minimums) Subscribe to Us for weekly Videos! Follow A.M on Facebook Here: https://www.facebook.com/AussieMuscle Follow A.M The Gym on Facebook Here: https://www.facebook.com/AustralianMuscleTheGym/ Follow ICN South Australia on Facebook Here: https://www.facebook.com/ICNSouthAustralia/

VASODILATION 101    What is Vasodilation?  Why is it important? How can we improve it?   Vasodilation is the process by which the blood vessels in the body relax and widen, allowing for greater blood flow. One of the main triggers of vasodilation is nitric oxide. Therefore, anything that increases nitric oxide production in the body will also increase vasodilation, the sensation bodybuilders refer to as the “pump.”   From an athlete’s perspective, vasodilation allows for an increase in oxygen and nutrient delivery within the body, allowing for greater energy production for the muscles. Vasodilation also helps improve the removal of catabolic waste products from the muscles like lactic acid and ammonia that contribute to muscle fatigue and failure.   CLICK TO FIND OUT MORE ABOUT MY DNA COACH ACADEMY    LINKS: Jonny's Instagram Jonny's Youtube   

Cyndi Doyle, law enforcement officer wife and licensed professional counselor, talks about what hypervigilance is, the process of it, and the biological effects that it has on our officers and first responders. This is going to be part one of a two part podcast. Intro and Outro music by Big State “Bad Timing / Bad Luck” Hypervigilance - https://en.wikipedia.org/wiki/Hypervigilance “Emotional Survival for Law Enforcement” by Kevin Gilmartin - https://www.amazon.com/Emotional-survival-law-enforcement-officers/dp/0971725403/ref=sr_1_1?ie=UTF8&qid=1505331271&sr=8-1&keywords=emotional+survival+for+law+enforcement OODA Loop Podcast - http://code4couples.libsyn.com/episode-4-does-your-leo-ooda FTO - https://en.wikipedia.org/wiki/Field_Training_Officer CHL - https://en.wikipedia.org/wiki/Concealed_carry_in_the_United_States RAS - https://en.wikipedia.org/wiki/Reticular_activating_system Sympathetic Nervous System - https://en.wikipedia.org/wiki/Sympathetic_nervous_system Vasodilation - https://en.wikipedia.org/wiki/Vasodilation Newton’s Third Law - https://en.wikipedia.org/wiki/Newton%27s_laws_of_motion Parasympathetic Nervous System -https://en.wikipedia.org/wiki/Parasympathetic_nervous_system My website: code4couples.com Social Media: Facebook - https://www.facebook.com/cyndidoylelpc/           Instagram - https://www.instagram.com/cyndi_doyle/?hl=en           LinkedIn - https://www.linkedin.com/in/cyndidoylelpc/           Pinterest - https://www.pinterest.com/cyndidoylelpc/pins/                         Twitter - https://twitter.com/cyndidlpc                         YouTube - https://www.youtube.com/channel/UCo8lSBy00E7vJnmh096Svog

Jonathan Jaggar explains how trafficking of regulatory subunits fine-tunes the activity of BK channels in arterial myocytes to limit vasoconstriction.

Part 2 of this exciting series on vasodilation. Matt talks about his breakthrough discovery in the new Prototype 8 formulation. Get Prototype 8 via our online store: https://atpscience.com/product/prototype-8

Vasodilation....what is it? why is everyone chasing "the pump"? What is Nitric Oxide? How do you increase vasodilation? In this exciting episode Jeff and Matt discuss how to utilise Nitric Oxide to build muscle tissue, what ingredients work and which do not and Matt makes a massive scientific breakthrough which may change the way you train forever.  Check out ATP Science's range of products at our online store  

Scott Earley explains how reactive oxygen species activate TRPA1 ion channels to trigger dilation of cerebral arteries.

Gregory Kato discusses a phase I study for the treatment of leg ulcers for people with sickle-cell disease.

Maximal blood vessel dilation can be induced by calcium influx through a just few channel molecules in vascular endothelial cells.

Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9068/1/9068.pdf Messmer, Konrad; Habazettl, H.; Zwißler, Bernhard; Welte, M.