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God Draws In Circles - Sunday Morning 06-14-26
G.K. Chesterton wrote that there are two ways of getting home—stay there, or walk around the entire world until you arrive from the other direction. For graphic novelist Ben Hatke, that line from The Everlasting Man wasn't simply a meditation on returning with fresh eyes: it became a commission. In this episode, Joe Grabowski sits down with Hatke—author of the forthcoming graphic memoir Home/World—to trace how one Chestertonian passage sent him east for 55 days across twelve countries, and how Chesterton's deepest convictions about man, story, and homecoming turned out to be more true the farther from home he traveled. In This Episode: How a single passage from G.K. Chesterton's The Everlasting Man—the two ways of getting home—became the animating vision behind a 55-day circumnavigation of the globe What Chesterton understood about encountering the world with fresh eyes: the generosity of strangers, the power of a story to cross any language barrier, and the world that waits beyond the screen How Ben Hatke wove historical figures—Ibn Battuta, Nellie Bly, Saint Francis—into the narrative as "ghosts," and why the Chestertonian idea of the communion of saints gives this technique its deepest meaning G.K. Chesterton's imagery of the circle and the line—from The Everlasting Man to Orthodoxy to The Man Who Was Thursday—and what it reveals about why a first encounter with any place is irrepeatable Why creating the book proved as life-changing as the journey itself and what Ben discovered about story, memory, and the difference between what is factual and what is true Chapters: 00:00: Welcome and Introduction 02:25: The Everlasting Man Quote Behind the Journey 06:01: Memory, Story, and How a Journey Becomes True 08:05: The Generosity of Strangers 13:37: Turkey and the Moment It Became an Adventure 22:33: Circumnavigating Post-COVID: The When and Why 31:02: "I Admire Your Life—It Looks Like Freedom" 35:03: Making the Book: Falling in Love with Storytelling Again 39:09: Historical Ghosts: Inviting the Past into the Journey 44:58: Circles and Lines: Chesterton's Vision of Coming Home Resources Mentioned: Home/World: A Circumnavigation of Our Shared Earth — Ben Hatke (forthcoming) Ben Hatke's website Ben Hatke on Patreon Ben Hatke on Instagram The Everlasting Man — G.K. Chesterton "Drawing Inspiration from Chesterton, with Ben Hatke" — previous Uncommon Sense appearance 2026 Chesterton Conference FOLLOW US: Instagram Facebook X SUPPORT: Donate Shop Produced by Saint Kolbe Studios
George Wright III interviews Braeden and Madison Furgeson, husband-and-wife founders of Venn Social, a bootstrapped, self-funded social platform designed around connection instead of attention. The idea began as an infertility support app after Madison struggled through years of infertility and miscarriages and found meaningful help only when matched with someone in the same stage, highlighting that topic-based groups lump very different situations together. They broadened the concept into a community platform for anyone seeking real connection. Venn Social features “circles” that use filtering questions to place users into sub-circles with people who answered similarly, a discover feed that prioritizes followed accounts and circles, and a transparent algorithm users can view. Culture is enforced through the Venn Code and an Aura score system that rewards good behavior and restricts trolls. They share a vision to replace toxic social media and help address loneliness.00:00 From Infertility to Connection00:51 Meet the Founders02:26 The Infertility Struggle05:36 Why Topic Groups Fail08:03 Bootstrapping Mission First10:10 Marriage as Co-Founders13:33 What Social Media Broke19:04 Defining Venn Social20:15 Circles and Filtering21:14 Circle Matching Topics22:02 Life Phases Mentors23:01 Discover Feed Explained24:59 Transparent Algorithm Rules26:11 Venn Code Culture27:52 Aura Score Moderation30:22 Creators Connection Focus35:03 Vision Replace Social37:53 Find Ven Download38:31 Closing Share EpisodeThanks for listening, and Please Share this Episode with someone. It would really help us to grow our show and share these valuable tips and strategies with others. Have a great day.George Wright III“It's Never Too Late to Start Living the Life You Were Meant to Live”FREE Daily Mastermind Resources:CONNECT with George & Access Tons of ResourcesGet access to Proven Strategies and Time-Test Principles for Success. Plus, download and access tons of FREE resources and online events by joining our Exclusive Community of Entrepreneurs, Business Owners, and High Achievers like YOU.Join FREE at DailyMastermind.comFollow me on social media Facebook | Instagram | Linkedin | TikTok | YoutubeGrow Your Authority and Personal Brand with a FREE Interview in a Top Global Magazine HERE.Guest BioBraeden and Madison Furgeson are the co-founders of Venn, a new social platform they built together to create a more meaningful way for people to connect online. Designed as the first troll-free, connection-based social network with a transparent algorithm, Venn helps users build authentic relationships by matching them into small communities of people experiencing similar life situations. Their mission is to serve those who are tired of traditional social media platforms that capture attention but often provide little value and leave users feeling more isolated. Entirely self-funded and built without outside investors, Braeden and Madison have personally invested everything into bringing Venn to life, driven by a belief that social media should strengthen human connection rather than diminish it.LinksWebsite: http://findmyvenn.com/LinkedIn: https://www.linkedin.com/in/braeden-furgeson/
What helps us widen our circles of care and awaken a more inclusive, compassionate heart? As we navigate political division, collective uncertainty, and personal challenges, mindful awareness and spiritual imagination can help us stay connected to love without being overwhelmed by the suffering we witness. Drawing from mindfulness, compassion practices, personal stories, and timeless wisdom teachings, Tara explores how we can move beyond fear, reactivity, and "othering" toward a deeper experience of our shared humanity. This talk is an invitation to reconnect with the truth of our belonging—to ourselves, to one another, and to the living world. When we deepen our attention and allow our hearts to be touched, we become part of weaving a more loving future. In this talk, you'll learn: -How fear and stress fuel division, blame, and "othering" -Why opening to suffering can deepen wisdom and compassion -The role of mindfulness in staying present without becoming overwhelmed -How spiritual imagination helps us envision and create a more loving world -Practices for recognizing the vulnerability and goodness in others Our introduction music is from "Opening" by Adrienne Torf, © 2025 ABT Music
We're back looking at another Object Board Circle from Assassin's Creed: Shadows. This one is a group of pirates and criminals. They also involve companion Oni-yuri. Listen now and let us know what you think! Now introducing Assassin's Creed Lorecast merch for everyone! Check it out at our shop! Want to chime in on the conversation? You can become a patron at the Master Assassin tier or higher and join us ON THE SHOW! https://www.patreon.com/aclorecast We've launched merch! Become a patron at the Assassin tier or higher to get these exclusive rewards! Check out our website! cupspodcasting.com If you enjoyed our podcast, give us a rating and review on Apple and/or Spotify! We'll even read your review out on the show! Join our The Cups Podcasts discord server where we dive deeep into all video game discussions. https://discord.gg/fxR2WVDNhP Come hang out on the Robots Radio discord server to join the fun! https://discord.gg/AW5Wc4kgZb If you love our merch, check out the artist behind the designs! https://libanezink.wixsite.com/libanezart If you love our music, check out the musician behind our theme! Pipeman Studios You can also find us on Twitter at @aclorecast, and you can dm us or email us at assassinscreedlorecast@gmail.com. Music by Pipeman Studios Website designed by H-I-T Media Solutions Merch designed by Lauren Ibañez Ink Learn more about your ad choices. Visit megaphone.fm/adchoices
When you're standing at life's crossroads—career, identity, or purpose whispering “there has to be more than this”—Pamela Stone delivers an audio letter straight to your heart. She reminds you that while everyone talks about the glow-up, no one warns you about the cost: letting go of habits, beliefs, and sometimes, even people. These changes, though lonely at times, are proof you're growing—not failing. You don't need to wait for permission or approval to rewrite your story. If you're ready to step into your next chapter—even if the path feels unclear—this loving message is for you. 3 Key Takeaways to Act On Today Release what no longer fits: Let go of outdated expectations, beliefs, and relationships that don't support your growth. Give yourself permission: You don't need anyone's approval to evolve or chase your dreams. Ask the right questions: Reflect on where you've been and where you want to go; your “what's next” starts by exploring what truly matters to you. You are not alone. This next chapter is yours to write. To Stay Connected with Me: www.sheshift.co
The Rebbe acknowledges the positive activities of Tishrei but stresses the need for greater expansion and outreach. He encourages the leadership to intensify efforts, especially among youth circles, and to continue publishing impactful materials. https://www.torahrecordings.com/rebbe/igroskodesh/008/002/2270
Post Malone Biography Flash a weekly Biography. Post Malone is in one of the most pivotal stretches of his career right now, blending stadium-sized success with a full pivot into country and major business moves that are going to matter in his biography for years to come. On the live front, Ticketmaster and AOL both highlight that he is deep into his 2026 Big Ass Stadium Tour, playing football stadiums like Bank of America Stadium in Charlotte with a setlist that leans heavily into his new country era, including Texas Tea, Pour Me a Drink, Dead at the Honky Tonk, and his Morgan Wallen duet I Had Some Help alongside legacy smashes like Circles, White Iverson, rockstar, and Sunflower. That consistent stadium routing is solidifying him as a true cross-genre arena-to-stadium headliner, not a passing pop fad. In interviews flagged by Billboard and recapped by country outlets, Post has confirmed that another full country album is coming “very, very soon,” on top of the record he is currently touring, meaning fans should expect an extended country phase rather than a one-off experiment. On stage at a recent show, fan-shot video shared on Instagram captures him telling the crowd he is releasing 40 songs and reminding them that he previously promised two albums in 2026, and on his own Instagram he has said his double album The Eternal Buzz is “99 percent done.” Together, those pieces point to a massive, multi-project release schedule that could redefine the middle period of his career. While exact release dates have not been officially locked in, the volume and consistency of his own comments make the multi-album plan more than mere speculation. Tour-wise, local authorities in East Hartford, Connecticut, have issued traffic alerts for a joint stadium date featuring Post Malone and Jelly Roll at Rentschler Field, and country trade coverage notes that the two will be sharing stages again in 2026, further cementing his acceptance inside the country ecosystem rather than just pop radio. Socially and culturally, new reporting from Asian Hospitality details that his December Guwahati, India headline show generated an estimated 4.5 million dollars in economic impact and helped anchor a projected 74 million dollar concert tourism pipeline for Assam over five years, a rare example of a single tour stop being cited in government-linked economic planning and a noteworthy biographical milestone in terms of global reach. On the business side, Nation's Restaurant News reports that Post has designed a custom Raising Cane's restaurant near his home in Midvale, Utah, a highly branded physical asset that extends his image into lifestyle and fast food culture, following his earlier collaborations with the chain. Meanwhile, recent analytics from influencer-tracking services like HypeAuditor put his Instagram following at roughly 26.5 million with six-figure estimated monthly ad value, underscoring his sustained digital influence even as his sound shifts toward country. Fan-side social clips circulating on Instagram in the past few days show Post Malone dedicating a show to Oliver Tree and participating in a heartwarming gesture for a young girl selling mental health support bracelets, surprising her with concert tickets and a meet and greet, an anecdote that reinforces his long-running public image as accessible and emotionally open with fans. At the rumor level, a Facebook group post accusing him of diva demands at a recent country festival remains unverified and sourced only to unnamed staff complaints; without corroboration from organizers, reputable media, or Post's camp, that story should be treated as gossip rather than confirmed behavior. There are no widely reported scandals or personal-life bombshells attached to his name in the last 24 hours from major outlets, but the drumbeat of stadium shows, the looming double album The Eternal Buzz, and his commitment to at least one more country record represent the core, long-term biographical storyline right now: Post Malone is actively rewriting what a modern crossover star can look like in real time. Thank you for listening, and be sure to subscribe so you never miss an update on Post Malone, and search the term Biography Flash for more great biographies. Thanks for listening. This has been a Quiet Please production. Get the best deals https://amzn.to/3ODvOta
Astros Keep Going In Circles… Hunter Brown Is Back! Sorsby Saga Is Over
Astros Keep Going In Circles… Hunter Brown Is Back! Sorsby Saga Is Over
Addiction, Accommodation, and Vulnerability in Psychoanalysis: Circles Without a Center (Routledge, 2022) explores the compulsions and trauma that underlie addiction, using an intersubjective approach in seeking to understand the inspirations and challenges arising from the psychoanalytic treatment of addiction, compulsivity, and related dissociative conditions. Drawing on insights from his own analytic practice and personal experience, in addition to the work of Stolorow, Brandchaft and Winnicott, among others, Haber considers the complex ways in which addiction becomes woven into a person's life, and analyses how it interacts with other problems such as depression and anxiety, self-fragmentation, and ambivalence about treatment. Haber creatively integrates the work of Camus, Kafka, and Beckett to further contemplate the dilemmas that can arise during the clinical process and, in identifying his own and his patients' vulnerabilities and contradictions, provides an honest, humorous and sometimes painful account of what happens in the consulting room. With its use of rich clinical material and an accessible and vivid writing style, this book will appeal to all psychoanalysts and psychotherapists working with patients affected by addiction, as well as other professionals seeking new insights into effective strategies for treating this most challenging malady. Darren M. Haber is a psychoanalyst practicing in west Los Angeles. Isak de Vries is a Psychoanalyst in private practice in New York City, New York. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/psychoanalysis
Addiction, Accommodation, and Vulnerability in Psychoanalysis: Circles Without a Center (Routledge, 2022) explores the compulsions and trauma that underlie addiction, using an intersubjective approach in seeking to understand the inspirations and challenges arising from the psychoanalytic treatment of addiction, compulsivity, and related dissociative conditions. Drawing on insights from his own analytic practice and personal experience, in addition to the work of Stolorow, Brandchaft and Winnicott, among others, Haber considers the complex ways in which addiction becomes woven into a person's life, and analyses how it interacts with other problems such as depression and anxiety, self-fragmentation, and ambivalence about treatment. Haber creatively integrates the work of Camus, Kafka, and Beckett to further contemplate the dilemmas that can arise during the clinical process and, in identifying his own and his patients' vulnerabilities and contradictions, provides an honest, humorous and sometimes painful account of what happens in the consulting room. With its use of rich clinical material and an accessible and vivid writing style, this book will appeal to all psychoanalysts and psychotherapists working with patients affected by addiction, as well as other professionals seeking new insights into effective strategies for treating this most challenging malady. Darren M. Haber is a psychoanalyst practicing in west Los Angeles. Isak de Vries is a Psychoanalyst in private practice in New York City, New York. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
In today's episode we revisit the Support Crucible concepts. Who do we trust and at which level do we trust them? Alec talks about having something invested when playing in teams, sports, in life. If everyone is invested, we can break those invisible lines - Welcome back to the Forged Ingold Podcast!If you like the show please subscribe and leave a 5 star rating - that and texting it to a friend are the easiest ways you can help us grow. Follow the podcast on Instagram: @ForgedIngold and email the show at forgedingoldpodcast@gmail.comAlec Ingold is an author, speaker, philanthropist, and professional football player. Learn more at alecingold.com
What really happens after someone completes the Ascension Channel Certification Program?Yesterday, I had the joy of sitting down with Eileen, one of the graduates from our previous certification intake, to reflect on her journey, her growth, and everything that has unfolded over the past two years since completing the training.Together, we explored what drew her to the program, the transformations she experienced along the way, how her relationship with channeling evolved, and the ways this work has supported her life, purpose, and spiritual path since certification.If you have ever been curious about the Ascension Channel Certification Program, wondered what makes this training unique, or felt the call to deepen your own gifts in a grounded, embodied, and sovereign way, I think you'll enjoy this conversation.There is something deeply powerful about hearing directly from those who have walked the path before you.Below you'll also find more information about Eileen, her work, and ways to connect with her.Enjoy the transmission!With Love,Cendrine. ***Eileen is a Self Connection Coach & Sacred Space Holder.Her deeply grounding & nurturing energy allows clients to meet the essence of their higher self and connect with their multidimensional nature. With a background in Nursing, Drug & Alcohol Counselling, Hypnotherapy, Energy Healing (Reiki & Sekem) and rich real world lived experience, Eileen is her to slay the shame and guide you back on to the path of your unique Sacred Journey. She can hold ALL of you. Her intention is that you may self-source your highest wisdom. She offers 1 on 1 Sacred Space Holding Sessions, Sacred Ancestral Healing & DNA recoding sessions and online Women's Circles.As a Stay at Home Mum currently, she has a dream to continue working from home in her soul aligned business ‘Leen In'. You can find her on Instagram: https://www.instagram.com/leen_in_with_eileen?igsh=MWNyMDRnNDk1a3B5cg==Website: https://eizaleen.wixsite.com/leenin Find her on FB: Eileen Mary Be***Cendrine is the founder of the Golden Age Spiritual Ministry and visionary leader of Harmonic Ascension, a global movement devoted to helping humanity remember their sovereign divinity. Born awake with the ability to connect with non-physical beings and other realities; she has walked through many initiations to consciously reactivate her gift. Now she teaches advanced technologies of sovereign crystalline ascension, guiding multidimensional souls to channel their Infinite Self and High Council of Light, embody their highest destiny, and move as dragons, with bold bravery, unshakeable faith and a touch of crazy that ignites the world.
Dave Ruff and Dillon Cheverere of the Circling Back Podcast join Barrett to discuss a celeb-packed Knicks game, summer style for the everyman, the resurgence of flip flops, and the ideal Father's Day. Subscribe to the Retail Therapy newsletter: https://retailpod.substack.com/ Shop the Sunday Scaries Scented Candles: https://www.vellabox.com/sundayscaries Watch all Retail Therapy episodes on YouTube: https://www.youtube.com/@SundayScariesPodcast Support This Week's Sponsors Leesa: Go to https://leesa.com/ for Early Access July 4th Sale 25% Off PLUS get an extra $50 off with promo code SCARIES Aura Frames: Exclusive $35-off Carver Mat at https://on.auraframes.com/RETAILPOD Promo Code RETAILPOD Follow Along Retail Therapy on Instagram: https://www.instagram.com/retail.pod Sunday Scaries on Twitter: https://www.twitter.com/sundayscaries Sunday Scaries on Instagram: https://www.instagram.com/sunday.scaries Will deFries on Twitter: https://www.twitter.com/willdefries Will deFries on Instagram: https://www.instagram.com/willdefries Barrett Dudley on Twitter: https://www.twitter.com/barrettdudley Barrett Dudley on Instagram: https://www.instagram.com/barrettdudley Learn more about your ad choices. Visit megaphone.fm/adchoices
What Teens Are Really Asking In this episode, Kristina Campos and Jenny Colman dive deep into the digital world adolescents navigate today, revealing the unspoken questions and curiosities teens have about relationships, boundary-crossing behaviors, and online content. Rather than looking for "how-to" guides, data from the What's Okay helpline shows that teens are overwhelmingly asking "Is this normal?" regarding things they witness or experience in the digital space [03:01]. They discuss how to spot red flags wh Rate, Review, & Subscribe! "I love Kristina and all the FREE tips that she has to offer! Thank you for making my parenting journey better!"
Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember
Writers want sharp dialogue, compelling conflict, and characters with enough tension to keep readers turning pages. But the problem is that conflict can easily get stuck. Characters snipe at each other, trade sarcasm, or argue at the same emotional level for too long. The scene has energy, but it does not move. The relationship does not shift. The reader starts to feel like the conversation is circling instead of building. In this episode, Laura Humm coaches Tony Maxwell on how to make character conflict escalate, de-escalate, and actually change the relationship between characters. They discuss how to balance prose and dialogue, how to use the "zipper" technique to check the rhythm of a conversation, and how to move an enemies-to-allies dynamic from hostility into vulnerability. They also dig into how to write an arrogant protagonist without making readers hate him, how to give both characters expertise and agency, and how to use specialized knowledge—like veterinary medicine—without turning the scene into an info dump. You'll learn how to make dialogue feel like a tennis match, how to hide exposition inside conflict, how to use vulnerability to shift a relationship, and how to make every joke, barb, and emotional landing serve the scene. Watch this episode if your characters have great banter but the scene still feels flat, if your exposition keeps slowing the story down, or if you're trying to write conflict that actually changes something. For more on writing dialogue, come to DialogueDoctor.com. For the Fiction Makers Conference, come to FictionMakers.Live
Justin Timberlake Biography Flash a weekly Biography. In the past few days, the most concrete Justin Timberlake update tied to business and public visibility is a mention in a Western Priorities report on the secretary of the interior and Yellowstone Club, which notes that Timberlake is among the celebrities and tech figures linked to the private club. That is not a new Timberlake project, but it is a recent reminder of his high end social and business circles, and it may matter more as a long term biography note than as a day to day entertainment headline. Beyond that, I do not see any verified major new music release, tour announcement, court development, or widely reported public appearance in the supplied results from the last few days. A Grammy archive item confirms Timberlake has long been a major awards era figure, but it is historical context rather than fresh news. I also do not have a reliable recent headline from the past 24 hours in the provided search set that indicates a major new Justin Timberlake development. There are a few social and fan driven references circulating online, including a YouTube mashup and a short video mentioning Timberlake, but those are not credible evidence of a real news event and should be treated as entertainment noise, not confirmed reporting. The Roland related short also appears to be a casual thank you post, not a substantive career update. So the verified picture right now is slim but clear: Timberlake remains a name that still surfaces in elite lifestyle and celebrity business coverage, but there is no confirmed major breaking story in the supplied material. If anything more dramatic is being whispered online, it is unconfirmed and should be treated cautiously until a reliable outlet reports it. Thank you for listening and subscribe to never miss an update on Justin Timberlake and search the term Biography Flash for more great Biographies. Thanks for listening. This has been a Quiet Please production. Get the best deals https://amzn.to/3ODvOta
Mike Schopp is joined by Matt Waldman to analyze the Buffalo Bills' roster. They discuss DJ Moore's integration into the offense, the evolution of Josh Allen's playing style compared to Lamar Jackson, and the team's historical playoff hurdles. 01:27 - Jack Adams Award Discussion 04:51 - DJ Moore Bills Fit 14:54 - Comparing Allen And Jackson 19:39 - Bills Playoff Struggles 25:25 - Skyler Bell Evaluation
Tyler Robinson, Markwayne Mullin, Ron DeSantis, and Graham Platner headline today's A.M. Update. Judge Tony Graf rules the public and press cannot be barred from Tyler Robinson's upcoming preliminary hearing, meaning potentially bombshell evidence against Charlie Kirk's alleged killer will be visible to the world. Iran remains a chaotic blur of strikes, broken communications, and shifting demands, with the IRGC now insisting any deal must include leaving Hezbollah alone in Lebanon, and Aaron says it's starting to look less like 3D chess and more like the U.S. being pressured. DHS Secretary Markwayne Mullin confirms some of the Delaney Hall protesters were bussed in from Portland, Oregon, as a curfew holds in Newark. Ron DeSantis pushes his case for eliminating Florida homestead property taxes, arguing tourist revenue can absorb the cost in a way no other state can replicate. Graham Platner loses The View and Cory Booker in the same news cycle as his Maine Senate campaign crumbles under the weight of sexting allegations, Nazi tattoo history, and a suspicious app account. Aaron closes with Rep. Tim Burchett's pitch to replace the 250th birthday concert dropouts with John Rich, Kid Rock, and Lee Greenwood, and the story of Henry Nowak, the British student handcuffed by police as he bled to death from a stab wound after his killer falsely claimed to be the victim.
Welcome back to Energetic Radio! After a six-month hiatus, Dale Sidebottom and Paul Campbell are back in a brand-new, custom-built studio complete with its own golf simulator. In this episode, they reflect on the break, sharing how time away has brought new inspiration, sharpened their focus on family, and provided some unforgettable “pinch me” and full-circle moments. From presenting at international conferences and revamping their original ClassBreak app, to meaningful moments with their kids both on and off the football field, they dive into the significance of appreciating success, taking risks, and creating lasting bonds. Plus, there's a sneak peek at their upcoming book, “Wolf Logic Leadership,” and candid discussions about leadership, motivation, and the power of pushing yourself beyond your comfort zone.Wolf Logic Book Pre-Order - https://ambapress.com.au/collections/coming-soon/products/wolf-logic-play-based-leadershipClassBreak (Our first ever app that started everything) - https://apps.apple.com/au/app/classbreak/id577991380
In this episode, Captain Kaye, the Animation Guru, and the Crazy Lemur share their thoughts on Decorado, the latest feature film from writer and director Alberto Vázquez, and Labyrinth, from director Shōji Kawamori!
This is the second part of my conversation with author Barry Kester whose fascinating new book is titled: Round In Circles — The Story of Rodgers & Hammerstein's CAROUSEL. Last week we focused on the three people most responsible for the creation of CAROUSEL — Oscar Hammerstein, Richard Rodgers, and the dynamic producer Theresa Helburn, whose vision and obsession it was to turn Ferenc Molnar's play Liliom into a musical. This week Barry takes us behind the scenes of CAROUSEL's rehearsal period and it's rocky out-of-town tryout including its very first performance in New Haven where the show ran more than four hours long! Along the way we have the opportunity to focus on the other key members of Carousel's creative team — choreographer Agnes De Mille, director Rouben Mamoulian, dance arranger Trude Rittmann, and orchestrator Don Walker — all of whom were crucial in helping Rodgers & Hammerstein turn what could have been a disaster into one of the landmark musicals of the “Golden Age of Broadway.” If you missed part one you may want to catch up with that episode before listening to this one. This episode is made possible in part through the generous support of Patron Club Members: Roger Kloresse, Elizabeth Troxler and Chris Moad. Thank you all! How to become A PATRON of Broadway Nation! If you are a fan of Broadway Nation, I invite you to become a PATRON! For a just $7.00 a month you can receive exclusive access to never-before-heard, unedited versions of many of the discussion that I have with my guests — in fact I often record nearly twice as much conversation as ends up in the edited versions. And you will also have access to additional in-depth conversations with my frequent co-host Albert Evans that have not been featured on the podcast. And all patrons receive special “on-air” shout-outs and acknowledgement of your vital support of this podcast. And If you are very enthusiastic about Broadway Nation there are additional PATRON levels that come with even more benefits. If you would like to support the work of Broadway Nation and receive these exclusive member benefits, please just click on this link: https://broadwaynationpodcast.supercast.tech/ Thank you in advance for your support! Learn more about your ad choices. Visit megaphone.fm/adchoices
Nobody likes getting up in the morning and looking in the mirror to find dreary bags and circles under their eyes. It can make you look tired and lower your self-confidence as you head to work, feeling like a zombie. But it's more than just an aesthetic issue. More often than not, it's an indication of poor health habits, and sometimes a sign of underlying medical conditions. So what actually causes those dreary circles? How worried should you be about seeing bags and circles under your eyes? What's the best way to deal with them then? In under 3 minutes, we answer your questions ! To listen to the last episodes, you can click here : What is online grooming? What does eating junk food do to our brains? Why do friend breakups hurt so much? A podcast written and realised by Joseph Chance. First Broadcast: 17/8/2022 Learn more about your ad choices. Visit megaphone.fm/adchoices
This episode features "Decimation Circles" written by Raahem Alvi. Published in the May 2026 issue of Clarkesworld Magazine and read by Kate Baker. The text version of this story can be found at: https://clarkesworldmagazine.com/alvi_05_26 Support us on Patreon at https://www.patreon.com/clarkesworld/membership
Want to build a stronger work culture where everyone feels welcome, heard, and valued? In this episode of the Build a Vibrant Culture Podcast, Nicole Greer sits down with speaker, author, and inclusion strategist Justin Jones-Fosu to explore how leaders can develop an inclusive mindset and why it matters more than ever for business culture and team performance.In this episode, you'll learn:✔️ The difference between an inclusive mindset and an exclusion mindset ✔️ Why most people mis-define diversity, and how to reframe it for your team ✔️ The growth mindset principles that make inclusion actually stick ✔️ Practical strategies like the 1MC/W formula and the Circles of Grace Challenge ✔️ How to create a work culture where people feel they truly belongThis episode is for leaders, managers, business owners, and professionals who want to improve organizational culture, strengthen team communication, and build workplaces where people thrive.Topics covered include: inclusive mindset, work culture, organizational culture, business culture, diversity and inclusion, leadership development, team communication, leadership and business, belonging at work, growth mindset, and career growth.Connect with Justin Jones-Fosu:
In this episode of the Essential Wellness Podcast, Aisha Harley and Arin Fugate explored the art of hosting women's circles as a way to create authentic community, share essential oils naturally, and foster meaningful connection. Through personal stories and practical guidance, they shared how simple gatherings in living rooms, parks, and backyards can evolve into powerful spaces for healing, learning, and relationship-building. The conversation highlighted how doTERRA businesses often grow organically through real-life experiences and education rather than sales tactics. From grounding rituals and sharing prompts to themed oil gatherings and community storytelling, this episode offered listeners an approachable way to begin creating circles of connection in their own communities.
On Tuesday, May 26, 2026, the Sonesta White Plains Downtown played host to the Business Council of Westchester's acclaimed Circles of Influence gathering. This premier mixer successfully united the region's leading executives, entrepreneurs, and industry innovators for a dynamic evening centered on strategic relationship-building and fresh economic prospects. Beyond traditional corporate mingling, attendees immersed themselves in unique, hands-on showcases presented by fellow BCW members, sparking collaborative dialogue and reinforcing the organization's vital role as a catalyst for local business growth and interconnected regional success.During the event, host Andrew Castellano sat down with Darren Smith, owner of Murphy Business Sales, which recently expanded its footprint into the region with a new Westchester office. Darren revealed that he officially joined the Business Council of Westchester that very evening, drawn in by the welcoming energy of the room and the caliber of the attendees. As a specialist in boutique investment and business sales for companies valued under $10 million in enterprise value, Darren shared valuable insights regarding the emotional and operational hurdles business owners face when preparing to sell.
On Tuesday, May 26, 2026, the Sonesta White Plains Downtown played host to the Business Council of Westchester's acclaimed Circles of Influence gathering. This premier mixer successfully united the region's leading executives, entrepreneurs, and industry innovators for a dynamic evening centered on strategic relationship-building and fresh economic prospects. Beyond traditional corporate mingling, attendees immersed themselves in unique, hands-on showcases presented by fellow BCW members, sparking collaborative dialogue and reinforcing the organization's vital role as a catalyst for local business growth and interconnected regional success.During the event, host Andrew Castellano interviewed Patrick Coyne of Alpine Saxon Woods, a wealth management firm that has served Westchester County for over three decades and manages more than $850 million in assets. Grounding his corporate philosophy in relationship-building, Patrick noted that the core of the investment industry is trust, an asset best cultivated through honest, face-to-face interactions like those offered at the Business Council of Westchester. He praised the organization's relaxed, low-pressure environment for allowing regional business neighbors to establish authentic friendships long before they ever need to call upon each other for commercial services.
Is done still better than perfect? Is the Canada goose a swan in less glamourous clothing? Are people who need people lucky or unlucky? The Queen of the Ducks (my bff Bekky) advises not to appear to be chasing the geese. The definition of sloth I printed out ends up being a diversion at the dinner table. "At least you're honest with yourself" says my Aunt Patti. The favorite podcast is not a podcast at all. It is: a VM from Yowei Shaw. DONATE to the Unemployed Philosophers Guild HERE [N.B: its the same as donating to mermaid palace or KP] Learn about your ad choices: dovetail.prx.org/ad-choices
My guest on Broadway Nation this week is Barry Kester, author of the fascinating new book: Round In Circles — The Story of Rodgers & Hammerstein's CAROUSEL. I thought I knew a lot about Carousel — and in fact Albert Evans and I have previously devoted several previous episodes to that show and its truly groundbreaking innovations. However, we both found this book to be filled with new information, new discoveries, and new insights. Based on his exemplary research, Barry Kester takes us deep inside Rodgers & Hammerstein's creative process as they endeavor to transform Ferenc Molnar's dark, fantastical play, Liliom, into their second Broadway musical collaboration, which they know will be compared to their first show, Oklahoma!, which had become the most successful Broadway Musical of all time and was still going strong! So, they consciously set out to do something very different. At the center of this story is a dynamic woman, producer Theresa Helborn, who was the inspiring, driving force behind the show. In fact, without Helborn there would have been no Carousel or Oklahoma! This is the first of three episodes in which Barry will share with us not only these fascinating stories but also his own unlikely and surprising tale of how he came to write this book. Become A PATRON of Broadway Nation! If you are a fan ofBroadway Nation, I invite you to become a PATRON! For a just $7.00 a month you can receive exclusive access to never-before-heard, unedited versions of many of the discussion that I have with my guests — in fact I often record nearly twice as much conversation as ends up in the edited versions. And you will also have access to additional in-depth conversations with my frequent co-host Albert Evans that have not been featured on the podcast. And all patrons receive special “on-air” shout-outs and acknowledgment of your vital support of this podcast. And if you are very enthusiastic about Broadway Nation, there are additional PATRON levels that come with even more benefits. If you would like to support the work of Broadway Nation and receive these exclusive member benefits, please just click on this link: https://broadwaynationpodcast.supercast.tech/ Thank you in advance for your support! Learn more about your ad choices. Visit megaphone.fm/adchoices
Let us know what you think about the podcast!Episode 218: How to Focus on What You Can Control When Family Relationships Are HardWhen a relationship is strained, it's so tempting to think: If I say it the right way… if I do enough… if I stay kind enough… then they'll finally respond the way I need them to. But the truth is, you can't control what someone else thinks, feels, or does. What you can control is how you show up, and that's where change begins.In this episode, you'll learn:How Stephen R. Covey's “Circles” framework helps you sort what you're worried about (concern) from what you can impact (influence) and what you can actually choose (control).The difference between control and influence and why confusing the two often leads to frustration, resentment, and burnout.Why blame, of yourself or others, quietly steals your power and what to do instead when you feel stuck.What “your inputs” really are in a struggling relationship and how to check whether you're expecting something different than what you're planting.A simple journaling question to help you reclaim steadiness and integrity: “Who am I being in the relationship, and how is that in my control?”When you focus on your circle of control, your thoughts, feelings, actions, and relational inputs, you stop chasing the impossible job of managing someone else's inner world. You may not be able to control outcomes, but you can keep planting what aligns with who you want to be. Over time, that steadiness changes you, and it often shifts the relationship more than force ever could. Tina Gosney is the Family Conflict Coach. She works with parents who have families in conflict to help them become the grounded, confident leaders their family needs. -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------If you want support putting what you're learning into practice, come join The Connection Community in Bridge to Connection. You'll get step-by-step relationship lessons, practical tools to calm anxiety and reduce conflict, and live monthly coaching calls to help you stay steady and build real connection with your child—especially when things feel tense. Learn more and join at https://www.courageous-connections.com/bridge-to-connection3---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tina is certified in family relationships and a trauma informed coach. Visit tinagosney.com for more information on coaching services.
We head to the Namib Desert in Africa, where the landscape is dotted with mysterious, pimple-like indents known as fairy circles. Where do these things come from? Scientist Walter Tschinkel has spent the last several years studying and experiencing a natural occurrence so enchanting, locals describe it as “The footprints of the gods.” READ MORE IN THE ATLAS: https://www.atlasobscura.com/places/fairy-circles-southern-africa Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Why does the rough mix always feel like the real song - and how the hell do you get that magic back without ruining it?In this episode, Pat Sansone and I go deep into the lifelong puzzle of mixing: why the first tracking rough has all the energy, how chasing it can make you crazy, and why mixing is really more like photography than engineering. Pat walks through how his visual art - Polaroids, slide film, CMYK vs RGB, Lambda printing - has taught him to trust instinct, appreciate imperfections, and approach mixes like developing a print rather than fixing a file. We talk about turning the screen off while playing a mix, the weird phenomenon of hearing a song differently once another person walks into the room, and why limitations make better records.We also dive into Pat's history with The Autumn Defense, Wilco, and the Big Star universe. Pat shares memories of making The Green Hour and Circles at my house - dragging the JH-16 up the stairs, tracking G-Whiz in the basement, and writing “The Answer” face-to-face with John Stirratt twenty feet from where we sat for this interview. He explains how the new Autumn Defense record Here and Nowhere came together after an eleven-year break, why Creative Workshop became the perfect studio for it, how Teddy Morgan helped capture tones, and why he still records acoustic and vocal together whenever possible. We get into gear, mic choices (KM84s, SM58s, Sony lavs), the struggle of acoustic/vocal bleed, and the random chaos of synths, plugins, and sessions that don't open right years later.Pat also talks about his photography book Noticing, his Infinity Mirrors ambient synth album, and how wandering with a camera unlocked the same creative freedom he felt as a teenager with a Korg Poly-6. He explains how Nashville re-energized his creative life - from running into Robyn Hitchcock in the cereal aisle at Turnip Truck to singing ooohs at Brendan Benson's studio the next day. We share memories of New Orleans, Chicago, analog tape, Pro Tools Mix+, transferring Birdy on the Moon tracks, losing Josh Shapera, and the role Creative Workshop played in Pat's “Nashville phase two.”By the end, we're talking Big Star, Eggleston photographs, orchestral arrangements, radio DJing, and why slide film and tube mics scratch the same itch. It's a wide-open conversation about creativity, sound, light, limitations, mistakes, rough mixes, and how to stay inspired for a lifetime.Get access to FREE mixing mini-course: https://MixMasterBundle.comTHANKS TO OUR SPONSORS!http://UltimateMixingMasterclass.comhttps://usa.sae.edu/ https://www.izotope.com Use code ROCK10 to get 10% off!https://www.native-instruments.com Use code ROCK10 to get 10% off!https://www.spectra1964.comhttps://gracedesign.com/https://pickrmusic.com https://RecordingStudioRockstars.com/Academyhttps://www.thetoyboxstudio.com/Listen to the podcast theme song “Skadoosh!” https://solo.to/lijshawmusicListen to this guest's discography on Spotify:https://open.spotify.com/playlist/0ZJrYkHqfDba4iL2InbLk9?si=HndgYrlWRzGusV2yOwzVagIf you love the podcast, then please leave a review: https://RSRockstars.com/ReviewCLICK HERE FOR COMPLETE SHOW NOTES AT: https://RSRockstars.com/559
We're back looking at another Object Board Circle from Assassin's Creed: Shadows. This one is an opposing group of Shinobi that value the Godai philosophy. They also involve companion and potential romance Katsuhime, and serve as somewhat of a foil to Naoe. Listen now and let us know what you think! Now introducing Assassin's Creed Lorecast merch for everyone! Check it out at our shop! Want to chime in on the conversation? You can become a patron at the Master Assassin tier or higher and join us ON THE SHOW! https://www.patreon.com/aclorecast We've launched merch! Become a patron at the Assassin tier or higher to get these exclusive rewards! Check out our website! cupspodcasting.com If you enjoyed our podcast, give us a rating and review on Apple and/or Spotify! We'll even read your review out on the show! Join our The Cups Podcasts discord server where we dive deeep into all video game discussions. https://discord.gg/fxR2WVDNhP Come hang out on the Robots Radio discord server to join the fun! https://discord.gg/AW5Wc4kgZb If you love our merch, check out the artist behind the designs! https://libanezink.wixsite.com/libanezart If you love our music, check out the musician behind our theme! Pipeman Studios You can also find us on Twitter at @aclorecast, and you can dm us or email us at assassinscreedlorecast@gmail.com. Music by Pipeman Studios Website designed by H-I-T Media Solutions Merch designed by Lauren Ibañez Ink Learn more about your ad choices. Visit megaphone.fm/adchoices
Anne Scott is the founder of Dream Weather Foundation and has led workshops and retreats for women from diverse communities and organizations around the country and the world. Her work centers on restoring the connection between feminine wisdom and social change, and on exploring the healing power of dreams. She has spoken to audiences across the U.S. and internationally—from Switzerland to India. In this episode Scott shares how facilitated women's circles offer a restorative space for genuine listening and healing. Participants gather to reflect, be heard, and rediscover inner wisdom, fostering resilience, creativity, and a renewed sense of belonging, while reconnecting with the love, joy, and creativity at the heart of our shared humanity. Her books include:Serving Fire: Food for Thought, Body, and Soul (Celestial Arts, 1994)The Laughing Baby (Celestial Arts, 2001)Women, Wisdom, and Dreams: The Light of the Feminine Soul (Nicasio Press, 2008)Finding Home: Restoring the Sacred to Life – Stories of Women in Homelessness & Transition (Nicasio Press, 2016)Listening Circles: Seeding Life – A Guide to Facilitating Women's Circles in Community (Nicasio Press, 2024)Interview Date: 4/3/2026 Tags: Anne Scott, Women's circles, feminine wisdom, listening circles, sacred space, silence, inner wisdom, marginalized women, women's shelter, authenticity, longing, Circles, Health & Healing, Meditation, Personal Transformation, Psychology, Social Change/Politics
Continuing the study of 1 John for Senior Sunday
James Lasdun describes the Murdaugh family's century-long dominance of South Carolina's legal system. He compares Alex's betrayal of trust and embezzlement to the intimate crimes punished in Dante's deepest circles of hell. (10/16)1920 CHARLESTON
This is the crazy story of some very typical, ornery high school baseball players in the '80's that found crazy success playing ball. And we had a teammate, Curt Whitaker that could sing and play guitar and we never knew it. When he decided, "why not?," he started KC's best cover band. The www.m80skc.com have played with Chicago, Train and others at Starlight and almost everyone that played at Knuckleheads as the totally fun 80's band. They dress the part and it's always a fun night out. Curt was a very talented pitcher that played in college and independent pro ball until his shoulder gave out. He worked, like the rest of us, and one day in his thirties he had an idea. This is a great convo about why the hell not pursue your American Dream.
PREVIEW for Later Today: Author James Lasdun explores the case of Alex Murdaugh, a convicted "beefy good old boy" killer and swindler. Lasdun connects Murdaugh's betrayal and embezzlement to Dante's circles of hell, analyzing the psychology of the crime.1793
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