Podcasts about senior investigator

Dr. Jacqueline Barry is the Chief Clinical Officer at Cell and Gene Therapy Catapult, Dr. Kapil Bharti is a Senior Investigator at the National Eye Institute at the National Institutes of Health, and Dr. Jack Mosher is the Scientific Director at the International Society for Stem Cell Research (ISSCR). They discuss their work on the ISSCR's Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies. They talk about the need for consistency and rigor in cell therapy development, and how the document can be navigated and applied across jurisdictions.

This episode features a conversation with Senior Investigator Avroy Fanaroff, Emeritus Professor at Rainbow Babies and Children's Hospital and Case Western Reserve University School of Medicine, who has had a long and impactful career in neonatology. Hosted on Acast. See acast.com/privacy for more information.

Today's episode was truly an enjoyable show to record: my guest is Matt Stegner, a former police officer having served with both the Atlanta (GA) Police Department and the New York State Police. We currently share the same profession…Matt is a trainer/consultant in specializing in trauma-informed investigations of sexual assault and rape cases. I had the pleasure of meeting him at an End Violence Against Women-International (EVAWI) conference after an amazing presentation he did. It's truly and honor and privilege to know Matt and call him a friend. Here's a little bit about Matt from his website: “His extensive experience as a Senior Investigator with the New York State Police (Ret.), especially in handling complex criminal investigations, speaks volumes about his expertise and dedication to the field. His specialization in areas like sexual assault, child exploitation, internet crimes against children, and interpersonal violence investigations showcases a commitment to addressing some of the most sensitive and crucial aspects of law enforcement.” (Cite: )  I encourage you to check out Matt's website and learn more about him and his amazing work! Here are the links to a couple of articles Matt has written:   I want to remind you—we all have a role to play in this fight. The first step? Start by Believing. When a survivor reaches out to tell their story, we need to listen without judgment, without skepticism. We need to believe them…because we all know someone whose life has been touched by sexual assault—whether it's a friend, a family member, or even ourselves. The more we normalize these conversations, the stronger we become in pushing back against rape culture and the systems that perpetuate it. An important side note: if you're finding value in these episodes, please take a moment to leave a 5-star rating on your podcast platform. AND,  please send me a note of support. I can't tell you how much your emails mean to me—they fuel my passion to keep this podcast going. Here's my email address:   I truly look forward to hearing from you! Thank you again for being part of this journey with me. Don't miss next week's episode as I bring you a new, compelling episode —right here on Sexual Assault Survivor Stories, the SASS Podcast. See you next week. In the meantime, we encourage you to share this episode with your friends, family, and colleagues. Spread the word about Sexual Assault Survivor Stories, as we continue to amplify the voices of survivors and educate the public and professionals on the importance of trauma-informed care. Together, we can make a difference. Resources: If you or someone you know is struggling with the impact of sexual assault, please reach out to a professional or utilize resources such as or Local Support Resources. Subscribe and Support: Don't forget to subscribe so you never miss an episode of Sexual Assault Survivor Stories; and, give us a five-star rating! Your support helps us continue to provide this important platform for survivors and advocates alike. I hope you will also do your part to bring justice to victims and survivors of rape and sexual assault. You can do that by sharing this episode with others. Also, please follow the Instagram page of sexualassaultsurvivorstories. It also helps the show grow, which is what I hope to accomplish to help lessen the prevalence of rape and sexual assault, as well as the prevalence of rape culture that surrounds us all. It only takes a minute, and I truly appreciate your support.  On another note: I am a strong advocate and supporter of Survivor School (SS), founded and directed by CEO Arci Grey. In fact, Arci has made me a consultant to SS as she maneuvers the intricacies of directing and managing the content and growth of her amazing organization. I encourage you to strongly consider becoming a member of SS, and as an affiliate would appreciate it, if you do decide to become a member, to use this link: Thanks again for listening! And as always, listed below are some additional important and meaningful websites I hope you'll take a look at and learn more about.   My email address:

On this week's Eye on Travel Podcast with Peter Greenberg, Peter has an in-depth conversation with Greg Feith - Former Senior Investigator of the National Transportation and Safety Board (NTSB) - on the latest aviation accident investigations and what lessons need to be learned -- and then applied. Then, we shift gears and focus on land travel with Anna Rooney - Head of Product Design at Collette Tours - on how smart tour planning has changed to focus on authenticity and the new importance of travel is being focused --not just where and when you travel but how. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

North Korea just executed the biggest crypto heist in history, stealing USD 1.5 billion from Bybit. But how did they do it? And can they be stopped? On this episode of TRM Talks, Jean Lee (The Lazarus Heist) and Nick Carlson (TRM Labs, Former FBI) join Ari to break down:The making of a cyber army — how North Korea recruits and trains hackers from childhoodThe Bybit hack step by step — from infiltration to laundering strategiesThe role of Chinese money laundering networks in enabling illicit financeWhat governments and public-private partnerships can do to disrupt these operationsWith cybercrime and national security threats on the rise, this is a conversation you can't afford to miss.Today's GuestsJean Lee, Journalist and Presidential Chair, East-West CenterNick Carlsen, Senior Investigator, TRM LabsHost: Ari Redbord, Global Head of Policy, TRM Labs

In honor of National Consumer Protection Week (NCPW), we're joined by the Federal Trade Commission (FTC) for a special episode of Consumer Connection! In this episode, host Michelle Escobar is joined by Diana Shiller, a Senior Investigator at the FTC. They discuss the FTC's role in protecting consumers nationwide and how the FTC works with local consumer protection groups. They also highlight key tactics and tips for avoiding imposter scams and deceptive business practices that listeners should know. For additional information and resources, visit OCP's website at www.montgomerycountymd.gov/ocp. Have a question or suggestion for a future episode? Send an email to consumerconnection@montgomerycountymd.gov.   Learn more about the Federal Trade Commission: https://www.ftc.gov/ 

Listen to January's Pediapod episode: Conversation With Senior Investigator Karin Nelson Hosted on Acast. See acast.com/privacy for more information.

From Detective to Senior Investigator to establishing a successful career in Cybersecurity, Andrew Morgan is the first guest of Tales from Tech Titans season 2.Andrew Morgan, a seasoned Chief Information Security Officer, with an inspiring—and, as he puts it, fun—career journey. Today, he brings his wealth of experience to the table for an insightful conversation you won't want to meet.

Niagara SPCA Senior Investigator Jonathan Bondi on Animal Abuse Arrest full 258 Fri, 27 Dec 2024 21:41:58 +0000 jQtEk27as1mNwlTg1dLU9SDorcD8SUIt news WBEN Extras news Niagara SPCA Senior Investigator Jonathan Bondi on Animal Abuse Arrest Archive of various reports and news events 2024 © 2021 Audacy, Inc. News False https://player.amperwa

On December 13, 2024 we spoke with the speakers at our annual UTSA Neuroscience Symposium, on the Basal Ganglia Circuitry. Topics of discussion included the heterogeneity of cells and connections, the usefulness of the idea of cell types (or lack thereof), and the relationship between neuromodulators and fast synaptic transmission. Sorry about the sound quality on this one. Guests: Charles Gerfen, Senior Investigator, National Institute of Mental Health Joshua Goldberg, Associate Professor, Department of Medical Neurobiology, The Hebrew University Zayd Khaliq, Senior Investigator, National Institute of Neurological Diseases and Stroke Tianyi Mao, Senior Scientist, Vollum Institute, Oregon Health & Science University Gilad Silberberg, Professor | Docent, Department of Neuroscience, Karolinska Institute D. James Surmeier, Professor, Department of Physiology, Feinberg School of Medicine, Northwestern University Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

Dr. Christoph Borchers is a Full Member in the McGill Centre for Translational Research in Cancer, Senior Investigator at the Lady Davis Institute for Medical Research, Director of the Segal Cancer Proteomics Centre, and Professor in the Department of Oncology at McGill University. In this episode, Christoph discusses his research in the area of proteomics and important applications of his work in anti-doping, including a PCC-funded research project examining quantitative proteomics longitudinally in blood to screen for blood doping. He also shares future directions for this line of research and his perspectives on important areas of opportunity in anti-doping science.

A leader for conducting rigorous randomized trials of humans along with animal models for understanding nutrition and metabolism, Dr. Kevin Hall is a Senior Investigator at the National Institutes of Health, and Section Chief of the Integrative Physiology Section, NIDDK. In this podcast, we reviewed his prolific body of research a recent publications. The timing of optimizing our diet and nutrition seems apropos, now that we're in in the midst of the holiday season!Below is a video snippet of our conversation on his ultra-processed food randomized trial.Full videos of all Ground Truths podcasts can be seen on YouTube here. The current one is here. If you like the YouTube format, please subscribe! The audios are also available on Apple and Spotify.Note: I'll be doing a Ground Truths Live Chat on December 11th at 12 N EST, 9 AM PST, so please mark your calendar and join!Transcript with links to publications and audioEric Topol (00:05):Well, hello. This is Eric Topol with Ground Truths, and I'm really delighted to have with me today, Dr. Kevin Hall from the NIH. I think everybody knows that nutrition is so important and Kevin is a leader in doing rigorous randomized trials, which is not like what we usually see with large epidemiologic studies of nutrition that rely on food diaries and the memory of participants. So Kevin, it's really terrific to have you here.Kevin Hall (00:34):Thanks so much for the invitation.Ultra-Processed FoodsEric Topol (00:36):Yeah. Well, you've been prolific and certainly one of the leaders in nutrition science who I look to. And what I thought we could do is go through some of your seminal papers. There are many, but I picked a few and I thought we'd first go back to the one that you published in Cell Metabolism. This is ultra-processed diets cause excessive caloric intake and weight gain. (Main results in graph below.) So maybe you can take us through the principle findings from that trial.Kevin Hall (01:10):Yeah, sure. So that was a really interesting study because it's the first randomized control trial that's investigated the role of ultra-processed foods in potentially causing obesity. So we've got, as you mentioned, lots and lots of epidemiological data that have made these associations between people who consume diets that are very high in ultra-processed foods as having greater risk for obesity. But those trials are not demonstrating causation. I mean, they suggest a strong link. And in fact, the idea of ultra-processed foods is kind of a new idea. It's really sort of appeared on the nutrition science stage probably most prominently in the past 10 years or so. And I first learned about this idea of ultra-processed foods, which is really kind of antithetical to the way most nutrition scientists think about foods. We often think about foods as nutrient delivery vehicles, and we kind of view foods as being the fraction of carbohydrates versus fats in them or how much sodium or fiber is in the foods.Kevin Hall (02:17):And along came this group in Brazil who introduced this new way of classifying foods that completely ignores the nutrient composition and says what we should be doing is classifying foods based on the extent and purpose of processing of foods. And so, they categorize these four different categories. And in the fourth category of this so-called NOVA classification scheme (see graphic below) , they identified something called ultra-processed foods. There's a long formal definition and it's evolved a little bit over the years and continues to evolve. But the basic ideas that these are foods that are manufactured by industries that contain a lot of purified ingredients made from relatively cheap agricultural commodity products that basically undergo a variety of processes and include additives and ingredients that are not typically found in home kitchens, but are typically exclusively in manufactured products to create the wide variety of mostly packaged goods that we see in our supermarkets.Kevin Hall (03:22):And so, I was really skeptical that there was much more about the effects of these foods. Other than that they typically have high amounts of sugar and saturated fat and salt, and they're pretty low in fiber. And so, the purpose of this study was to say, okay, well if there's something more about the foods themselves that is causing people to overconsume calories and gain weight and eventually get obesity, then we should do a study that's trying to test for two diets that are matched for these various nutrients of concern. So they should be matched for the macronutrients, they should be matched for the sugar content, the fat, the sodium, the fiber, and people should just be allowed to eat whatever they want and they shouldn't be trying to change their weight in any way. And so, the way that we did this was, as you mentioned, we can't just ask people to report what they're eating.Kevin Hall (04:19):So what we did was we admitted these folks to the NIH Clinical Center and to our metabolic ward, and it's a very artificial environment, but it's an environment that we can control very carefully. And so, what we basically did is take control over their food environment and we gave them three meals a day and snacks, and basically for a two-week period, they had access to meals that were more than 80% of calories coming from ultra-processed foods. And then in random order, they either received that diet first and give them simple instructions, eat as much as little as you want. We're going to measure lots of stuff. You shouldn't be trying to change your weight or weight that gave them a diet that had no calories from ultra-processed foods. In fact, 80% from minimally processed foods. But again, both of these two sort of food environments were matched for these nutrients that we typically think of as playing a major role in how many calories people choose to eat.Kevin Hall (05:13):And so, the basic idea was, okay, well let's measure what these folks eat. We gave them more than double the calories that they would require to maintain their weight, and what they didn't know was that in the basement of the clinical center where the metabolic kitchen is, we had all of our really talented nutrition staff measuring the leftovers to see what it was that they didn't eat. So we knew exactly what we provided to them and all the foods had to be in our nutrition database and when we compute what they actually ate by difference, so we have a very precise estimate about not only what foods they chose to ate, but also how many calories they chose to eat, as well as the nutrient composition.And the main upshot of all that was that when these folks were exposed to this highly ultra-processed food environment, they spontaneously chose to eat about 500 calories per day more over the two-week period they were in that environment then when the same folks were in the environment that had no ultra-processed foods, but just minimally processed foods. They not surprisingly gained weight during the ultra-processed food environment and lost weight and lost body fat during the minimally processed food environment. And because those diets were overall matched for these different nutrients, it didn't seem to be that those were the things that were driving this big effect. So I think there's a couple of big take homes here. One is that the food environment really does have a profound effect on just the biology of how our food intake is controlled at least over relatively short periods of time, like the two-week periods that we were looking at. And secondly, that there's something about ultra-processed foods that seem to be driving this excess calorie intake that we now know has been linked with increased risk of obesity, and now we're starting to put some of the causal pieces together that really there might be something in this ultra-processed food environment that's driving the increased rates of obesity that we've seen over the past many decades.Eric Topol (07:18):Yeah, I mean I think the epidemiologic studies that make the link between ultra-processed foods and higher risk of cancer, cardiovascular disease, type 2 diabetes, neurodegenerative disease. They're pretty darn strong and they're backed up by this very rigorous study. Now you mentioned it short term, do you have any reason to think that adding 500 calories a day by eating these bad foods, which by the way in the American diet is about 60% or more of the average American diet, do you have any inkling that it would change after a few weeks?Kevin Hall (07:54):Well, I don't know about after a few weeks, but I think that one of the things that we do know about body weight regulation and how it changes in body weight impact both metabolism, how many calories were burning as well as our appetite. We would expect some degree of moderation of that effect eventually settling in at a new steady state, that's probably going to take months and years to achieve. And so the question is, I certainly don't believe that it would be a 500 calorie a day difference indefinitely. The question is when would that difference converge and how much weight would've been gained or lost when people eventually reached that new plateau? And so, that's I think a really interesting question. Some folks have suggested that maybe if you extrapolated the lines a little bit, you could predict when those two curves might eventually converge. That's an interesting thought experiment, but I think we do need some longer studies to investigate how persistent are these effects. Can that fully explain the rise in average body weight and obesity rates that have occurred over the past several decades? Those are open questions.Eric Topol (09:03):Yeah. Well, I mean, I had the chance to interview Chris van Tulleken who wrote the book, Ultra-Processed People and I think you might remember in the book he talked about how he went on an ultra-processed diet and gained some 20, 30 pounds in a short time in a month. And his brother, his identical twin brother gained 50, 60 pounds, and so it doesn't look good. Do you look at all the labels and avoid all this junk and ultra-processed food now or are you still thinking that maybe it's not as bad as it looks?Kevin Hall (09:38):Well, I mean I think that I certainly learned a lot from our studies, and we are continuing to follow this up to try to figure out what are the mechanisms by which this happen. But at the same time, I don't think we can throw out everything else we know about nutrition science. So just because we match these various nutrients in this particular study, I think one of the dangers here is that as you mentioned, there's 60% of the food environment in the US and Great Britain and other places consist of these foods, and so they're unavoidable to some extent, right? Unless you're one of these privileged folks who have your backyard garden and your personal chef who can make all of your foods, I'm certainly not one of those people, but for the vast majority of us, we're going to have to incorporate some degree of ultra-processed foods in our day-to-day diet.Kevin Hall (10:24):The way I sort of view it is, we really need to understand the mechanisms and before we understand the mechanisms, we have to make good choices based on what we already know about nutrition science, that we should avoid the foods that have a lot of sugar in them. We should avoid foods that have a lot of saturated fat and sodium. We should try to choose products that contain lots of whole grains and legumes and fruits and vegetables and things like that. And there's some of those, even in the ultra-processed food category. I pretty regularly consume a microwavable ready meal for lunch. It tends to be pretty high in whole grains and legumes and low in saturated fat and sugar and things like that. But to engineer a food that can heat up properly in a microwave in four minutes has some ultra-processing technology involved there. I would be pretty skeptical that that's going to cause me to have really poor health consequences as compared to if I had the means to eat homemade French fries every day in tallow. But that's the kind of comparison that we have to think about.Eric Topol (11:36):But I think what you're touching on and maybe inadvertently is in that NOVA class four, the bad ultra-processed foods, there's a long, long list of course, and some of those may be worse than others, and we haven't seen an individual ranking of these constituents. So as you're alluding to what's in that microwave lunch probably could be much less concerning than what's in these packaged snacks that are eaten widely. But I would certainly agree that we don't know everything about this, but your study is one of the most quoted studies ever in the ultra-processed food world. Now, let me move on to another trial that was really important. This was published in Nature Medicine and it's about a plant-based diet, which is of course a very interesting diet, low-fat versus an animal-based ketogenic diet. Also looking at energy intake. Can you take us through that trial?Plant-Based, Low Fat Diet vs Animal-Based, Low Carbohydrate Ketogenic DietKevin Hall (12:33):Sure. So it's actually interesting to consider that trial in the context of the trial we just talked about because both of these diets that we tested in this trial were relatively low in ultra-processed foods, and so both of them contained more than a kilogram of non-starchy vegetables as a base for designing these, again, two different food environments. Very similar overall study design where people again were exposed to either diets that were vegan plant-based diet that was really high in starches and was designed to kind of cause big insulin increases in the blood after eating the meals. And the other diet had very, very few carbohydrates of less than 10% in total, and we built on that kind of non-starchy vegetable base, a lot of animal-based products to kind of get a pretty high amount of fat and having very low carbohydrates. Both diets in this case, like I mentioned, were pretty low in ultra-processed foods, but what we were really interested in here was testing this idea that has come to prominence recently, that high carbohydrate diets that lead to really large glucose excursions after meals that cause very high insulin levels after meals are particularly obesogenic and should cause you to be hungrier than compared to a diet that doesn't lead to those large swings in glucose and insulin and the prototypical case being one that's very low in carbohydrate and might increase the level of ketones that are floating around in your blood, which are hypothesized to be an appetite suppressant. Same sort of design, these minimally processed diets that one was very high in carbs and causes large swings in insulin and the other that's very low in carbs and causes increases in ketones.Kevin Hall (14:22):We ask people, again, while you're in one food environment or the other, don't be trying to gain weight or lose weight, eat as much or as little as you'd like, and we're going to basically measure a lot of things. They again, don't know what the primary outcome of the study is. We're measuring their leftovers afterwards. And so, the surprise in this particular case was that the diet that caused the big swings in glucose and insulin did not lead to more calorie consumption. In fact, it led to about 700 calories per day less than when the same people were exposed to the ketogenic diet. Interestingly, both food environments caused people to lose weight, so it wasn't that we didn't see the effect of people over consuming calories on either diet, so they were reading fewer calories in general than they were when they came in, right. They're probably eating a pretty ultra-processed food diet when they came in. We put them on these two diets that varied very much in terms of the macronutrients that they were eating, but both were pretty minimally processed. They lost weight. They ended up losing more body fat on the very low-fat high carb diet than the ketogenic diet, but actually more weight on the ketogenic diet than the low-fat diet. So there's a little bit of a dissociation between body fat loss and weight loss in this study, which was kind of interesting.Eric Topol (15:49):Interesting. Yeah, I thought that was a fascinating trial because plant-based diet, they both have their kind of camps, you know.Kevin Hall (15:57):Right. No, exactly.Immune System Signatures for Vegan vs Ketogenic DietsEric Topol (15:58):There are people who aren't giving up on ketogenic diet. Of course, there's some risks and some benefits and there's a lot of interest of course with the plant-based diet. So it was really interesting and potentially the additive effects of plant-based with avoidance or lowering of ultra-processed food. Now, the more recent trial that you did also was very interesting, and of course I'm only selecting ones that I think are particularly, there are a lot of trials you've done, but this one is more recent in this year where you looked at vegan versus ketogenic diets for the immune signature, immune response, which is really important. It's underplayed as its effect, and so maybe you can take us through that one.[Link to a recent Nature feature on this topic, citing Dr. Hall's work]Kevin Hall (16:43):Yeah, so just to be clear, it's actually the same study, the one that we just talked about. This is a secondary sort of analysis from a collaboration we had with some folks at NIAID here at the NIH to try to evaluate immune systems signatures in these same folks who wonder what these two changes in their food environment. One is vegan, high carbohydrate low-fat diet and the other, the animal-based ketogenic diet. And again, it was pretty interesting to me that we were able to see really substantial changes in how the immune system was responding. First of all, both diets again seem to have improved immune function, both adaptive and innate immune function as compared to their baseline measurements when they came into the study. So when they're reading their habitual diet, whatever that is typically high in ultra-processed foods, they switched to both of these diets.Kevin Hall (17:39):We saw market changes in their immune system even compared to baseline. But when we then went and compared the two diets, they were actually divergent also, in other words, the vegan diet seemed to stimulate the innate immune system and the ketogenic diet seemed to stimulate the adaptive immune system. So these are the innate immune system can be thought of. Again, I'm not an immunologist. My understanding is that this is the first line defense against pathogens. It happens very quickly and then obviously the adaptive immune system then adapts to a specific pathogen over time. And so, this ability of our diet to change the immune system is intriguing and how much of that has to do with influencing the gut microbiota, which obviously the gut plays a huge role in steering our immune system in one direction versus another. I think those are some really intriguing mechanistic questions that are really good fodder for future research.Eric Topol (18:42):Yeah, I think it may have implications for treatment of autoimmune diseases. You may want to comment about that.Kevin Hall (18:51):Yeah, it's fascinating to think about that the idea that you could change your diet and manipulate your microbiota and manipulate your gut function in a way to influence your immune system to steer you away from a response that may actually be causing your body damage in your typical diet. It's a fascinating area of science and we're really interested to follow that up. I mean, it kind of supports these more anecdotal reports of people with lupus, for example, who've reported that when they try to clean up their diet for a period of time and eliminate certain foods and eliminate perhaps even ultra-processed food products, that they feel so much better that their symptoms alleviate at least for some period of time. Obviously, it doesn't take the place of the therapeutics that they need to take, but yeah, we're really interested in following this up to see what this interaction might be.Eric Topol (19:46):Yeah, it's fascinating. It also gets to the fact that certain people have interesting responses. For example, those with epilepsy can respond very well to a ketogenic diet. There's also been diet proposed for cancer. In fact, I think there's some even ongoing trials for cancer of specific diets. Any comments about that?Kevin Hall (20:10):Yeah, again, it's a really fascinating area. I mean, I think we kind of underappreciate and view diet in this lens of weight loss, which is not surprising because that's kind of where it's been popularized. But I think the role of nutrition and how you can manipulate your diet and still you can have a very healthy version of a ketogenic diet. You can have a very healthy version of a low-fat, high carb diet and how they can be used in individual cases to kind of manipulate factors that might be of concern. So for example, if you're concerned about blood glucose levels, clearly a ketogenic diet is moderating those glucose levels over time, reducing insulin levels, and that might have some positive downstream consequences and there's some potential downsides. Your apoB levels might go up. So, you have to kind of tune these things to the problems and the situations that individuals may face. And similarly, if you have issues with blood glucose control, maybe a high carbohydrate diet might not be for you, but if that's not an issue and you want to reduce apoB levels, it seems like that is a relatively effective way to do that, although it does tend to increase fasting triglyceride levels.Kevin Hall (21:27):So again, there's all of these things to consider, and then when you open the door beyond traditional metabolic health markers to things like inflammation and autoimmune disease as well as some of these other things like moderating how cancer therapeutics might work inside the body. I think it's a really fascinating and interesting area to pursue.Eric Topol (21:55):No question about it. And that also brings in the dimension of the gut microbiome, which obviously your diet has a big influence, and it has an influence on your brain, brain-gut axis, and the immune system. It's all very intricate, a lot of feedback loops and interactions that are not so easy to dissect, right?Kevin Hall (22:16):Absolutely. Yeah, especially in humans. That's why we rely on our basic science colleagues to kind of figure out these individual steps in these chains. And of course, we do need human experiments and carefully controlled experiments to see how much of that really translates to humans, so we need this close sort of translational partnership.On the Pathogenesis of Obesity, Calories In and Calories OutEric Topol (22:35):Yeah. Now, you've also written with colleagues, other experts in the field about understanding the mechanisms of pathogenesis of obesity and papers that we'll link to. We're going to link to everything for what we've been discussing about calories in, calories out, and that's been the longstanding adage about this. Can you enlighten us, what is really driving obesity and calories story?Kevin Hall (23:05):Well, I co-organized a meeting for the Royal Society, I guess about a year and a half ago, and we got together all these experts from around the world, and the basic message is that we have lots of competing theories about what is driving obesity. There's a few things that we all agree on. One is that there is a genetic component. That adiposity in a given environment is somewhere between 40% to 70% heritable, so our genes play a huge role. It seems like there's certain genes that can play a major role. Like if you have a mutation in leptin, for example, or the leptin receptor, then this can have a monogenic cause of obesity, but that's very, very rare. What seems to be the case is that it's a highly polygenic disease with individual gene variants contributing a very, very small amount to increased adiposity. But our genes have not changed that much as obesity prevalence has increased over the past 50 years. And so, something in the environment has been driving that, and that's where the real debates sort of starts, right?Kevin Hall (24:14):I happen to be in the camp that thinks that the food environment is probably one of the major drivers and our food have changed substantially, and we're trying to better understand, for example, how ultra-processed foods which have risen kind of in parallel with the increased prevalence of obesity. What is it about ultra-processed foods that tend to drive us to overconsume calories? Other folks focus maybe more on what signals from the body have been altered by the foods that we're eating. They might say that the adipose tissue because of excess insulin secretion for example, is basically driven into a storage mode and that sends downstream signals that are eventually sensed by the brain to change our appetite and things like that. There's a lot of debate about that, but again, I think that these are complementary hypotheses that are important to sort out for sure and important to design experiments to try to figure out what is more likely. But there is a lot of agreement on the idea that there's something in our environment has changed.Kevin Hall (25:17):I think there's even maybe a little bit less agreement of exactly what that is. I think that there's probably a little bit more emphasis on the food environment as opposed to there are other folks who think increased pollution might be driving some of this, especially endocrine disrupting chemicals that have increased in prevalence. I think that's a viable hypothesis. I think we have to try to rank order what we think are the most likely and largest contributors. They could all be contributing to some extent and maybe more so in some people rather than others, but our goal is to try to, maybe that's a little simple minded, but let's take the what I think is the most important thing and let's figure out the mechanisms of that most important thing and we'll, number one, determine if it is the most important thing. In my case, I think something about ultra-processed foods that are driving much of what we're seeing. If we could better understand that, then we could both advise consumers to avoid certain kinds of foods because of certain mechanisms and still be able to consume some degree of ultra-processed foods. They are convenient and tasty and relatively inexpensive and don't require a lot of skill and equipment to prepare. But then if we focus on the true bad guys in that category because we really understand the mechanisms, then I think that would be a major step forward. But that's just my hypothesis.Eric Topol (26:43):Well, I'm with you actually. Everything I've read, everything I've reviewed on ultra-processed food is highly incriminating, and I also get frustrated that nothing is getting done about it, at least in this country. But on the other hand, it doesn't have to be either or, right? It could be both these, the glycemic index story also playing a role. Now, when you think about this and you're trying to sort out calories in and calories out, and let's say it's one of your classic experiments where you have isocaloric proteins and fat and carbohydrate exactly nailed in the different diets you're examining. Is it really about calories or is it really about what is comprising the calorie?Kevin Hall (27:29):Yeah, so I think this is the amazing thing, even in our ultra-processed food study, if we asked the question across those people, did the people who ate more calories even in the ultra-processed diet, did they gain more weight? The answer is yes.Kevin Hall (27:44):There's a very strong linear correlation between calorie intake and weight change. I tend to think that I started my career in this space focusing more on the metabolism side of the equation, how the body's using the calories and how much does energy expenditure change when you vary the proportion of carbs versus fat, for example. The effect size is there, they might be there, but they're really tiny of the order of a hundred calories per day. What really struck me is that when we just kind of changed people's food environments, the magnitude of the effects are like we mentioned, 500 to 700 calories per day differences. So I think that the real trick is to figure out how is it that the brain is regulating our body weight in some way that we are beginning to understand from a molecular perspective? What I think is less well understood is, how is that food intake control system altered by the food environment that we find ourselves in?The Brain and GLP-1 DrugsKevin Hall (28:42):There are a few studies now in mice that are beginning to look at how pathways in the brain that have been believed to be related to reward and not necessarily homeostatic control of food intake. They talk to the regions of the brain that are related to homeostatic control of food intake, and it's a reciprocal sort of feedback loop there, and we're beginning to understand that. And I think if we get more details about what it is in our foods that are modulating that system, then we'll have a better understanding of what's really driving obesity and is it different in different people? Are there subcategories of obesity where certain aspects of the food environment are more important than others, and that might be completely flipped in another person. I don't know the answer to that question yet, but it seems like there are certain common factors that might be driving overall changes in obesity prevalence and how they impact this reward versus homeostatic control systems in the brain, I think are really fascinating questions.Eric Topol (29:43):And I think we're getting much more insight about this circuit of the reward in the brain with the food intake, things like optogenetics, many ways that we're getting at this. And so, it's fascinating. Now, that gets me to the miracle drug class GLP-1, which obviously has a big interaction with obesity, but of course much more than that. And you've written about this as well regarding this topic of sarcopenic obesity whereby you lose a lot of weight, but do you lose muscle mass or as you referred to earlier, you lose body fat and maybe not so much muscle mass. Can you comment about your views about the GLP-1 family of drugs and also about this concern of muscle mass loss?Kevin Hall (30:34):Yeah, so I think it's a really fascinating question, and we've been trying to develop mathematical models about how our body composition changes with weight gain and weight loss for decades now. And this has been a long topic, one of the things that many people may not realize is that people with obesity don't just have elevated adiposity, they also have elevated muscle mass and lean tissue mass overall. So when folks with obesity lose weight, and this was initially a pretty big concern with bariatric surgery, which has been the grandfather of ways that people have lost a lot of weight. The question has been is there a real concern about people losing too much weight and thereby becoming what you call sarcopenic? They have too little muscle mass and then they have difficulties moving around. And of course, there are probably some people like that, but I think what people need to realize is that folks with obesity tend to start with much higher amounts of lean tissue mass as well as adiposity, and they start off with about 50% of your fat-free mass, and the non-fat component of your body is skeletal muscle.Kevin Hall (31:45):So you're already starting off with quite a lot. And so, the question then is when you lose a lot of weight with the GLP-1 receptor agonist or with bariatric surgery, how much of that weight loss is coming from fat-free mass and skeletal muscle versus fat mass? And so, we've been trying to simulate that using what we've known about bariatric surgery and what we've known about just intentional weight loss or weight gain over the years. And one of the things that we found was that our sort of expectations for what's expected for the loss of fat-free mass with these different drugs as well as bariatric surgery, for the most part, they match our expectations. In other words, the expected amount of fat loss and fat free mass loss. The one outlier interestingly, was the semaglutide study, and in that case, they lost more fat-free mass than would be expected.Kevin Hall (32:44):Now, again, that's just raising a little bit of a flag that for whatever reason, from a body composition perspective, it's about a hundred people underwent these repeated DEXA scans in that study sponsored by Novo Nordisk. So it's not a huge number of people, but it's enough to really get a good estimate about the proportion of weight loss. Whether or not that has functional consequences, I think is the open question. There's not a lot of reports of people losing weight with semaglutide saying, you know what? I'm really having trouble actually physically moving around. I feel like I've lost a lot of strength. In fact, it seems to be the opposite, right, that the quality of the muscle there seems to be improved. They seem to have more physical mobility because they've lost so much more weight, that weight had been inhibiting their physical movement in the past.Kevin Hall (33:38):So it's something to keep an eye on. It's an open question whether or not we need additional therapies in certain categories of patients, whether that be pharmacological, there are drugs that are interesting that tend to increase muscle mass. There's also other things that we know increase muscle mass, right? Resistance exercise training, increase this muscle mass. And so, if you're really concerned about this, I certainly, I'm not a physician, but I think it's something to consider that if you go on one of these drugs, you might want to think about increasing your resistance exercise training, maybe increasing the protein content of your diet, which then can support that muscle building. But I think it's a really interesting open question about what the consequences of this might be in certain patient populations, especially over longer periods of time.Dietary Protein, Resistance Exercise, DEXA ScansEric Topol (34:30):Yeah, you've just emphasized some really key points here. Firstly, that resistance exercise is good for you anyway. And get on one of these drugs, why don't you amp it up or get it going? The second is about the protein diet, which it'd be interesting to get your thoughts on that, but we generally have too low of a protein diet, but then there are some who are advocating very high protein diets like one gram per pound, not just one gram per kilogram. And there have been studies to suggest that that very high protein diet could be harmful, but amping up the protein diet, that would be a countering thing. But the other thing you mentioned is a DEXA scan, which can be obtained very inexpensively, and because there's a variability in this muscle mass loss if it's occurring, I wonder if that's a prudent thing or if you just empirically would just do the things that you mentioned. Do you have any thoughts about that?Kevin Hall (35:32):Yeah, that's really a clinical question that I don't deal with on a day-to-day basis. And yeah, I think there's probably better people suited to that. DEXA scans, they're relatively inexpensive, but they're not readily accessible to everyone. I certainly wouldn't want to scare people away from using drugs that are now known to be very effective for weight loss and pretty darn safe as far as we can tell, just because they don't have access to a DEXA scanner or something like that.Eric Topol (36:00):Sure. No, that makes a lot of sense. I mean, the only reason I thought it might be useful is if you're concerned about this and you want to track, for example, how much is that resistant training doing?Kevin Hall (36:13):But I think for people who have the means to do that, sure. I can't see any harm in it for sure.Continuous Glucose Sensors?Eric Topol (36:19):Yeah. That gets me to another metric that you've written about, which is continuous glucose tracking. As you know, this is getting used, I think much more routinely in type one insulin diabetics and people with type 2 that are taking insulin or difficult to manage. And now in recent months there have been consumer approved that is no prescription needed, just go to the drugstore and pick up your continuous glucose sensor. And you've written about that as well. Can you summarize your thoughts on it?Kevin Hall (36:57):Yeah, sure. I mean, yeah, first of all, these tools have been amazing for people with diabetes and who obviously are diagnosed as having a relative inability to regulate their glucose levels. And so, these are critical tools for people in that population. I think the question is are they useful for people who don't have diabetes and is having this one metric and where you target all this energy into this one thing that you can now measure, is that really a viable way to kind of modulate your lifestyle and your diet? And how reliable are these CGM measurements anyway? In other words, do they give the same response to the same meal on repeated occasions? Does one monitor give the same response as another monitor? And those are the kinds of experiments that we've done. Again, secondary analysis, these trials that we talked about before, we have people wearing continuous glucose monitors all the time and we know exactly what they ate.Kevin Hall (37:59):And so, in a previous publication several years ago, we basically had two different monitors. One basically is on the arm, which is the manufacturer's recommendation, the other is on the abdomen, which is the manufacturer's recommendation. They're wearing them simultaneously. And we decided just to compare what were the responses to the same meals in simultaneous measurements. And they were correlated with each other thankfully, but they weren't as well predictive as you might expect. In other words, one device might give a very high glucose reading to consuming one meal and the other might barely budge, whereas the reverse might happen for a different meal. And so, we asked the question, if we were to rank the glucose spikes by one meal, so we have all these meals, let's rank them according to the glucose spikes of one device. Let's do the simultaneous measurements with the other device.Kevin Hall (38:53):Do we get a different set of rankings? And again, they're related to each other, but they're not overlapping. They're somewhat discordant. And so, then the question becomes, okay, well if I was basically using this one metric to kind of make my food decisions by one device, I actually start making different decisions compared to if I happen to have been wearing a different device. So what does this really mean? And I think this sort of foundational research on how much of a difference you would need to make a meaningful assessment about, yeah, this is actionable from a lifestyle perspective, even if that is the one metric that you're interested in. That sort of foundational research I don't think has really been done yet. More recently, we asked the question, okay, let's ignore the two different devices. Let's stick to the one where we put it on our arm, and let's ask the question.Kevin Hall (39:43):We've got repeated meals and we've got them in this very highly regimented and controlled environment, so we know exactly what people ate previously. We know the timing of the meals, we know when they did their exercise, we know how much they were moving around, how well they slept the night before. All of these factors we could kind of control. And the question that we asked in that study was, do people respond similarly to the same meal on repeated occasions? Is that better than when you actually give them very different meals? But they match overall for macronutrient content, for example. And the answer to that was surprisingly no. We had as much variability in the glucose response to the same person consuming the same meal on two occasions as a whole bunch of different meals. Which suggests again, that there's enough variability that it makes it difficult to then recommend on for just two repeats of a meal that this is going to be a meal that's going to cause your blood glucose to be moderate or blood glucose to be very high. You're going to have to potentially do this on many, many different occasions to kind of figure out what's the reliable response of these measurements. And again, that foundational research is typically not done. And I think if we're really going to use this metric as something that is going to change our lifestyles and make us choose some meals other than others, then I think we need that foundational research. And all we know now is that two repeats of the same meal is not going to do it.Eric Topol (41:21):Well, were you using the current biosensors of 2024 or were you using ones from years ago on that?Kevin Hall (41:27):No, we were using ones from several years ago when these studies were completed. But interestingly, the variability in the venous measurements to meal tests is also very, very different. So it's probably not the devices per se that are highly variable. It's that we don't really know on average how to predict these glucose responses unless there's huge differences in the glycemic load. So glycemic load is a very old concept that when you have very big differences in glycemic load, yeah, you can on average predict that one kind of meal is going to give rise to a much larger glucose excursion than another. But typically these kind of comparisons are now being made within a particular person. And we're comparing meals that might have quite similar glycemic loads with the claim that there's something specific about that person that causes them to have a much bigger glucose spike than another person. And that we can assess that with a couple different meals.Eric Topol (42:31):But also, we know that the spikes or the glucose regulation, it's very much affected by so many things like stress, like sleep, like exercise. And so, it wouldn't be at all surprising that if you had the exact same food, but all these other factors were modulated that it might not have the same response. But the other thing, just to get your comment on. Multiple groups, particularly starting in Israel, the Weizmann Institute, Eran Segal and his colleagues, and many subsequent have shown that if you give the exact same amount of that food, the exact same time to a person, they eat the exact same amount. Their glucose response is highly heterogeneous and variable between people. Do you think that that's true? That in fact that our metabolism varies considerably and that the glucose in some will spike with certain food and some won't.Kevin Hall (43:29):Well, of course that's been known for a long time that there's varying degrees of glucose tolerance. Just oral glucose tolerance tests that we've been doing for decades and decades we know is actually diagnostic, that we use variability in that response as diagnostic of type 2 diabetes.Eric Topol (43:49):I'm talking about within healthy people.Kevin Hall (43:53):But again, it's not too surprising that varying people. I mean, first of all, we have a huge increase in pre-diabetes, right? So there's various degrees of glucose tolerance that are being observed. But yeah, that is important physiology. I think the question then is within a given person, what kind of advice do we give to somebody about their lifestyle that is going to modulate those glucose responses? And if that's the only thing that you look at, then it seems like what ends up happening, even in the trials that use continuous glucose monitors, well big surprise, they end up recommending low carbohydrate diets, right? So that's the precision sort of nutrition advice because if that's the main metric that's being used, then of course we've all known for a very long time that lower carbohydrate diets lead to a moderated glucose response compared to higher carbohydrate diets. I think the real question is when you kind of ask the issue of if you normalize for glycemic load of these different diets, and there are some people that respond very differently to the same glycemic load meal compared to another person, is that consistent number one within that person?Kevin Hall (45:05):And our data suggests that you're going to have to repeat that same test multiple times to kind of get a consistent response and be able to make a sensible recommendation about that person should eat that meal in the future or not eat that meal in the future. And then second, what are you missing when that becomes your only metric, right? If you're very narrowly focused on that, then you're going to drive everybody to consume a very low carbohydrate diet. And as we know, that might be great for a huge number of people, but there are those that actually have some deleterious effects of that kind of diet. And if you're not measuring those other things or not considering those other things and put so much emphasis on the glucose side of the equation, I worry that there could be people that are being negatively impacted. Not to mention what if that one occasion, they ate their favorite food and they happen to get this huge glucose spike and they never eat it again, their life is worse. It might've been a complete aberration.Eric Topol (46:05):I think your practical impact point, it's excellent. And I think one of the, I don't know if you agree, Kevin, but one of the missing links here is we see these glucose spikes in healthy people, not just pre-diabetic, but people with no evidence of glucose dysregulation. And we don't know, they could be up to 180, 200, they could be prolonged. We don't know if the health significance of that, and I guess someday we'll learn about it. Right?Kevin Hall (46:36):Well, I mean that's the one nice thing is that now that we have these devices to measure these things, we can start to make these correlations. We can start to do real science to say, what a lot of people now presume is the case that these spikes can't be good for you. They must lead to increased risk of diabetes. It's certainly a plausible hypothesis, but that's what it is. We actually need good data to actually analyze that. And at least that's now on the table.Eric Topol (47:04):I think you're absolutely right on that. Well, Kevin, this has been a fun discussion. You've been just a great leader in nutrition science. I hope you'll keep up your momentum because it's pretty profound and I think we touched on a lot of the uncertainties. Is there anything that I didn't ask you that you wish I did?Kevin Hall (47:23):I mean, we could go on for hours, I'm sure, Eric, but this has been a fascinating conversation. I really appreciate your interest. Thank you.Eric Topol (47:30):Alright, well keep up the great stuff. We'll be following all your work in the years ahead, and thanks for joining us on Ground Truths today.**************************************Footnote, Stay Tuned: Julia Belluz and Kevin Hall have a book coming out next September titled “WHY WE EAT? Thank you for reading, listening and subscribing to Ground Truths.If you found this fun and informative please share it!All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary. All proceeds from them go to support Scripps Research. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. I welcome all comments from paid subscribers and will do my best to respond to them and any questions.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research.Note on Mass Exodus from X/twitter:Many of you have abandoned the X platform for reasons that I fully understand. While I intend to continue to post there because of its reach to the biomedical community, I will post anything material here in the Notes section of Ground Truths on a daily basis and cover important topics in the newsletter/analyses. You can also find my posts at Bluesky: @erictopol.bsky.social, which is emerging as an outstanding platform for sharing life science. Get full access to Ground Truths at erictopol.substack.com/subscribe

In this episode of The Future Conceived, Dr. Yu-Ying Chen, postdoctoral fellow at NIEHS and member of the SSR Virtual Education Committee, sits down with Dr. Francesco DeMayo, the 2024 recipient of SSR's highest honor, The Carl G. Hartman award. Dr. DeMayo is the the Chief and Senior Investigator in the Reproductive and Developmental Biology Laboratory at the National Institute for Environmental Health Sciences (NIEHS / NIH). Listen in as Dr. DeMayo discusses his career trajectory, his research in uterine biology and gives some words of wisdom for the next generation of reproductive biologists.

This episode features a conversation with Senior Investigator Michael DeBaun, Professor of Pediatrics and Medicine at Vanderbilt University Medical Center, who has had a long career investigating the causes of and treatments for sickle cell anemia, and advocating for children and adults with this condition across the globe. You can access his Vanderbilt page here: Michael R. DeBaun, MD, MPH | Department of Pediatrics Hosted on Acast. See acast.com/privacy for more information.

This episode features a conversation with Senior Investigator Tina Cheng, who has held several leadership positions over her career, including her current roles as Chair of Pediatrics at the University of Cincinnati, and Director of the Cincinnati Children's Research Foundation. Her clinical work and research work have had a long and lasting impact on child health disparities and health equity. Hosted on Acast. See acast.com/privacy for more information.

Robert Wittman wrote the New York Times best-selling memoir Priceless: How I Went Undercover to Rescue the World's Stolen Treasures, with 2009 Pulitzer Prize Finalist John Shiffman. Priceless follows Wittman through his career with the FBI, providing a first-perspective account of some of the most well-known art heists in modern history and the undercover FBI stings that sought to foil them. He joined the FBI as a Special Agent in 1988 and was assigned to the Philadelphia Field Division. As a result of specialized training in art, antiques, jewelry and gem identification, he served as the FBI's investigative expert in art and cultural property crime investigations. During his 20 year career with the FBI, he recovered more that $300 million worth of stolen art and cultural property resulting in the prosecution and conviction of numerous individuals. In 2005, he was instrumental in the creation of the FBI's rapid deployment Art Crime Team (ACT). He was named the ACT's Senior Investigator and was tasked with instructing the team's founding members in cultural property investigation techniques. He has represented the United States around the world conducting investigations and instructing international police and museums in investigation, recovery and security techniques. Show Host - Toni Ann Marcolini PODCAST PODCAST INSTAGRAM

This month features a conversation with Senior Investigator, Professor Richard Jackson, who's had an extensive career in Public Health. Now Professor Emeritus at the Fielding School of Public Health at the University of California, Los Angeles, Richard has served in many leadership positions including nine years as Director of the CDC's National Centre for Environmental Health. Our conversation covered a wide range of topics affecting children's health, from pesticides to urban planning to gun violence, testament to his rich and varied career. Hosted on Acast. See acast.com/privacy for more information.

Col. Grant Newsham, Senior Research Fellow at Japan Forum for Strategic Studies I discussed the threat to the national security of the United States with Colonel Grant Newsham. We not only don't know who's running the government, but we have reason to believe among those is a man who is a controlled asset of the Chinese Communist Party, at the very least Hunter Biden, if not his dad.  We also discussed Japan's state of preparedness to help us in the event of Chinese aggression in the Far East, the shocking discovery that there is a tremendous deficit in the recruitment of individuals for the Japanese military, and what we must do to try to shore up our ally in that regard.   Stephen Bryen, Former Senior Staff Dir. of the U.S. Senate Foreign Relations Committee Stephen Bryen and I visited about the efforts of NATO on the occasion of its 75th-anniversary summit meeting here in Washington, DC, to essentially lock in the policy towards Ukraine to prevent President Trump from being able to change course if he sees fit and wins the White House again.  We also discussed the extent to which NATO and the United States government's promises to Ukraine, especially to arm it, may prove inadequate and unavailing. Bill Marshall, Senior Investigator, Judicial Watch In a conversation with Bill Marshall of Judicial Watch, we talked about the January 6th false flag operation and the evidence of its true character that Judicial Watch is trying to obtain through freedom of action and freedom of information requests as what it means that the United States Army has changed the mission statement of the at West Point that will be harmful in the extreme to future leaders of our armed forces and their ability to perform their mission.

Since Dr. Matthew Johnson first appeared on 12 Geniuses in September of 2020 to discuss The Future of Psychedelics, popular opinion in favor of this category of drugs has surged and so has the research and potential uses for psilocybin, MDMA, LSD, ayahuasca, and other drugs that fit into the broader category of psychedelics. Dr. Johnson and his research have been critical to fueling these growing trends. In this interview, Dr. Johnson discusses the advancements in psychedelic research that have been made in the last few years, how favorable public opinion about the use of these once taboo drugs continues to grow, and he closes the conversation with his sobering advice for people who are experimenting on their own with these drugs, going on weekend psychedelic retreats, or even going to South America to have ayahuasca experiences with a shaman. Dr. Matthew Johnson is Senior Investigator in Psychedelics at Sheppard Pratt and Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University where he is one of the world's most published scientists on the human effects of psychedelics. He had conducted seminal research in the behavioral economics of drug use, addiction, and risk behavior. Dr. Johnson published psychedelic safety guidelines in 2008, helping to resurrect psychedelic research.

In this episode, we speak with Dr. Matthew Johnson about the use of psychedelic therapy for enhancing mental health. Dr. Johnson is a Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University and most recently a Senior Investigator in Psychedelics at Sheppard Pratt further. He is one of the world's most published scientists on the human effects of psychedelics, and has conducted seminal research in the behavioral economics of drug use, addiction, and risk behavior. Dr. Johnson was the 2019 President of the Psychopharmacology and Substance Abuse Division of the American Psychological Association, and is currently President of the International Society for Research on Psychedelics. Our discussion spans the fundamental aspects of these substances, their application in therapy, and what one can expect from a psychedelic experience. This conversation sheds light on the preparation required prior to embarking on such a journey, offers detailed insights on dosage and the experience itself, and emphasizes the importance of integration post-experience.  If the exploration of psychedelic medicine's healing potential captivates you, this episode is not to be missed. Host: Brent Franson, Founder & CEO, Most Days Guest: Dr. Matthew Johnson Music: Patrick Lee Producer: Patrick Godino

Sithabiso Buthelezi is the Senior Investigator for the Competition Commissionand he joins John to explain the Commission's warning that they intend toprosecute schools that are limiting parents to buying uniforms from onesupplier only.See omnystudio.com/listener for privacy information.

Today on One Life Radio, we had Chris Gronkowski on the air to start off with a little football and dive right into his 2023 highlights along with his goals for 2024. Chris Gronkowski is the owner and inventor of the Ice Shaker, vacuum insulated bottles that hold ice for over 30 hours. In 2017, Chris and his brothers successfully pitched Ice Shaker on Shark Tank, ultimately partnering with Mark Cuban who helped grow the brand nationally. Before founding Ice Shaker, Chris played in the NFL for the Dallas Cowboys, Indianapolis Colts, and Denver Broncos.  Next up, we welcomed Dr. Philip William Gold to dive into his latest book “Breaking Through Depression“ and answers our questions on depressive disorders. Dr. Gold is one of the world's leading researchers of depressive illness. For over three decades he has worked at the National Institutes of Health, where he has served as Chief of Neuroendocrine Research and Senior Investigator in the National Institute of Mental Health Intramural Research Program, and Chief of the Section on Neuroendocrinology. In his recent book, Breaking Through Depression: A Guide to the Next Generation of Promising Research and Revolutionary New Treatments, he draws upon his long-term research to delve into the interplay between our anatomy and our lived experiences as the key to understanding why there are such individual differences in how we make connections with others, deal with adversity, or recover from trauma. In his role at the NIH, Dr. Gold has studied the neurobiology of depression for decades and led a laboratory of over 30 individuals trained in neuroscience, molecular biology, endocrinology, neurology and psychiatry. He has written over 400 scientific articles that have been cited by over 65,000 publications including 16 in The New England Journal of Medicine. Dr. Gold has served as a member of the Library of Congress Council of Scholars, participated in the MacArthur Foundation Medical Network, received an Honorary Doctorate from the University of Athens School of Medicine, and was chosen as a Distinguished Alumnus of the Duke University School of Medicine. He also received The American Psychiatric Association highest honor, The Foundation Fund Prize for Research, and has delivered honorary lectures at Harvard University and the Japan Foundation. Here are more episodes with Chris Gronkowski:Chris Gronkowski - Entrepreneurial Segment, Brett Larkin - How to Channel Joy Amidst the Chaos with Yoga #3020WELLNESS WEDNESDAY Chris Gronkowski - Breaking a World Record, Sally K. Norton - Dangers of Oxalates #3002Chris Gronkowski - Football and Fall Workouts, William W. Li, M.D. - Foods for Longevity #2082Thank you to our sponsors!Enviromedica – Rewild your gut with spore-based probiotics and wild-harvested prebiotics designed to support a healthy and diverse microbiome.Children's Health Defense - Listen every Monday as we cover the top stories from the CHD‘s Defender NewsletterSunwarrior - Use the code OLR for 20% off your purchase!Well Being Journal - For nutritional, mental, emotional, social, and spiritual health.Thorne - Get 20% off your order and free shipping!

CHERYL CHUMLEY, Author, “The Devil in DC,” Opinion Editor, The Washington Times, Twitter: @ckchumley Is there going to be “election interference” in the 2024 presidential election? What is the basis for the new case against Donald Trump? What is the most persecuted religion around the world? BILL MARSHALL, Senior Investigator, Judicial Watch Robert F. Kennedy Jr. being denied Secret Service protection Who is making the decision on providing Secret Service protection to RFK Jr.? An update on investigations into potential criminal activity by the Biden family TYLER O'NEIL, Managing Editor, The Daily Signal A new “hate group” labeled by the Southern Poverty Law Center Why does the SPLC have bank accounts in the Cayman Islands? Has the federal government “teamed up” with the SPLC? How the SPLC has “bolstered” their hate group list

Philip Gold is one of the world's leading researchers of depressive illness. Since 1974, he has worked at the National Institute of Health, where he has served as Chief of Neuroendocrine Research, and Senior Investigator in the National Institute of Mental Health Intramural Research Program, and Chief of the Section on Neuroendocrinology. For this episode, he joins science communicator and Postdoctoral fellow at The Francis Crick Institute, Dr Güneş Taylor, in conversation to talk about his life's work and the findings of his recent book: Breaking Through Depression.  We'd love to hear your feedback and what you think we should talk about next, who we should have on and what our future debates should be.  Send us an email or voice note with your thoughts to podcasts@intelligencesquared.com or Tweet us @intelligence2. And if you'd like to support our mission to foster honest debate and compelling conversations, as well as ad-free podcasts, exclusive bonus content, early access and much more, become a supporter of Intelligence Squared. Just visit intelligencesquared.com/membership to find out more.  Learn more about your ad choices. Visit megaphone.fm/adchoices

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Join America's Roundtable (https://americasrt.com/) radio co-hosts Natasha Srdoc and Joel Anand Samy with former Senior FBI Official Debra LaPrevotte, a principled leader fighting international corruption, adversely impacting America and its trusted allies. Debra LaPrevotte is the Senior Investigator for The Sentry (https://www.youtube.com/watch?v=cI_1l_8qTiE). The Sentry is an investigative and policy organization that seeks to disable multinational predatory networks that benefit from violent conflict, repression, and kleptocracy. Debra LaPrevotte served as a Supervisory Special Agent on the International Corruption Unit at FBI Headquarters. Debra was instrumental in initiating the FBI's Kleptocracy program and seized more than $1 billion dollars from foreign corrupt officials. Debra retired after 20 years with the Federal Bureau of Investigation. Prior to her FBI career, Debra LaPrevotte worked for the Department of Defense for five years. Debra has an undergraduate degree from George Mason University and a masters degree in Forensic Science from George Washington University. Key Topics on America's Roundtable Radio: — The significant impact of international corruption on America and the rest of Western democracies. — Each year corruption and illicit financial flows cost the global economy US$3.6 trillion. — Croatia, the only European Union member put on international money laundering and terrorism financing "grey list." (https://leaderssummit.medium.com/croatia-the-only-eu-member-state-put-on-money-laundering-and-terrorism-financing-grey-list-by-2fa16381c026) | Croatia is also a NATO member receiving US aid via the Pentagon, USAID, and US taxpayer funds backing the World Bank's grants and loans to the Balkan nation. | “U.S. military assistance to Croatia has reached nearly a billion dollars in the form of training, equipment, infrastructure construction, and specialized military education, including $140 million in support just this year for the Croatian Armed Forces” — U.S. Chargé d'Affaires Mark Fleming, US Embassy in Zagreb. — US aid and the West's assistance versus principled efforts to strengthen the rule of law and reform weak judiciaries in poor countries and aid-dependent post-communist Eastern European nations facing rampant corruption. — Focusing on principled solutions. Further reading: Croatia — The Only EU Member State Put on Money-Laundering and Terrorism Financing ‘Grey List' by FATF (https://leaderssummit.medium.com/croatia-the-only-eu-member-state-put-on-money-laundering-and-terrorism-financing-grey-list-by-2fa16381c026) “Yugoslavia's tragedy was not foreordained. It was the product of bad, even criminal, political leaders who encouraged ethnic confrontation for personal, political and financial gain. Rather than tackle the concrete problems of governance in post-Tito era, they led their people into war.” — Richard Holbrooke, US diplomat and author of “To End a War” Take a Listen! | A Nation for Thieves with Debra LePravotte | Lionsgate Sound (https://lionsgatesound.com/shows/a-nation-for-thieves) Trillions of dollars derived from corruption are moved around the world every year. Justin Shenkarow sits down with FBI veteran Debra LaPrevotte, who has spent the last 25 years chasing down kleptocrats and corrupt officials all around the world. Debra single-handedly built the FBI's Kleptocracy division from the ground up - tracking, tracing and seizing over one billion dollars worth of assets. She is one of the world's leading anti-corruption experts. Debra's career began at Quantico, the FBI's prestigious training academy. A Nation for Thieves is a Lionsgate Sound podcast, engineered by Pilgrim Media americasrt.com (https://americasrt.com/) https://ileaderssummit.org/ | https://jerusalemleaderssummit.com/ America's Roundtable on Apple Podcasts: https://podcasts.apple.com/us/podcast/americas-roundtable/id1518878472 Twitter: @DebraLaprevotte @ileaderssummit @AmericasRT @NatashaSrdoc @JoelAnandUSA @supertalk America's Roundtable is co-hosted by Natasha Srdoc and Joel Anand Samy, co-founders of International Leaders Summit and the Jerusalem Leaders Summit. America's Roundtable (https://americasrt.com/) radio program - a strategic initiative of International Leaders Summit, focuses on America's economy, healthcare reform, rule of law, security and trade, and its strategic partnership with rule of law nations around the world. The radio program features high-ranking US administration officials, cabinet members, members of Congress, state government officials, distinguished diplomats, business and media leaders and influential thinkers from around the world. Tune into America's Roundtable Radio program from Washington, DC via live streaming on Saturday mornings via 65 radio stations at 7:30 A.M. (ET) on Lanser Broadcasting Corporation covering the Michigan and the Midwest market, and at 7:30 A.M. (CT) on SuperTalk Mississippi — SuperTalk.FM reaching listeners in every county within the State of Mississippi, and neighboring states in the South including Alabama, Arkansas, Louisiana and Tennessee. Listen to America's Roundtable on digital platforms including Apple Podcasts, Spotify, Amazon, Google and other key online platforms. Listen live, Saturdays at 7:30 A.M. (CT) on SuperTalk | https://www.supertalk.fm

Join America's Roundtable (https://americasrt.com/) radio co-hosts Natasha Srdoc and Joel Anand Samy with former Senior FBI Official Debra LaPrevotte, a principled leader fighting international corruption, adversely impacting America and its trusted allies. Debra LaPrevotte is the Senior Investigator for The Sentry (https://www.youtube.com/watch?v=cI_1l_8qTiE). The Sentry is an investigative and policy organization that seeks to disable multinational predatory networks that benefit from violent conflict, repression, and kleptocracy. Debra LaPrevotte served as a Supervisory Special Agent on the International Corruption Unit at FBI Headquarters. Debra was instrumental in initiating the FBI's Kleptocracy program and seized more than $1 billion dollars from foreign corrupt officials. Debra retired after 20 years with the Federal Bureau of Investigation. Prior to her FBI career, Debra LaPrevotte worked for the Department of Defense for five years. Debra has an undergraduate degree from George Mason University and a masters degree in Forensic Science from George Washington University. Key Topics on America's Roundtable Radio: — The significant impact of international corruption on America and the rest of Western democracies. — Each year corruption and illicit financial flows cost the global economy US$3.6 trillion. — Croatia, the only European Union member put on international money laundering and terrorism financing "grey list." (https://leaderssummit.medium.com/croatia-the-only-eu-member-state-put-on-money-laundering-and-terrorism-financing-grey-list-by-2fa16381c026) | Croatia is also a NATO member receiving US aid via the Pentagon, USAID, and US taxpayer funds backing the World Bank's grants and loans to the Balkan nation. | “U.S. military assistance to Croatia has reached nearly a billion dollars in the form of training, equipment, infrastructure construction, and specialized military education, including $140 million in support just this year for the Croatian Armed Forces” — U.S. Chargé d'Affaires Mark Fleming, US Embassy in Zagreb. — US aid and the West's assistance versus principled efforts to strengthen the rule of law and reform weak judiciaries in poor countries and aid-dependent post-communist Eastern European nations facing rampant corruption. — Focusing on principled solutions. Further reading: Croatia — The Only EU Member State Put on Money-Laundering and Terrorism Financing ‘Grey List' by FATF (https://leaderssummit.medium.com/croatia-the-only-eu-member-state-put-on-money-laundering-and-terrorism-financing-grey-list-by-2fa16381c026) “Yugoslavia's tragedy was not foreordained. It was the product of bad, even criminal, political leaders who encouraged ethnic confrontation for personal, political and financial gain. Rather than tackle the concrete problems of governance in post-Tito era, they led their people into war.” — Richard Holbrooke, US diplomat and author of “To End a War” Take a Listen! | A Nation for Thieves with Debra LePravotte | Lionsgate Sound (https://lionsgatesound.com/shows/a-nation-for-thieves) Trillions of dollars derived from corruption are moved around the world every year. Justin Shenkarow sits down with FBI veteran Debra LaPrevotte, who has spent the last 25 years chasing down kleptocrats and corrupt officials all around the world. Debra single-handedly built the FBI's Kleptocracy division from the ground up - tracking, tracing and seizing over one billion dollars worth of assets. She is one of the world's leading anti-corruption experts. Debra's career began at Quantico, the FBI's prestigious training academy. A Nation for Thieves is a Lionsgate Sound podcast, engineered by Pilgrim Media americasrt.com (https://americasrt.com/) https://ileaderssummit.org/ | https://jerusalemleaderssummit.com/ America's Roundtable on Apple Podcasts: https://podcasts.apple.com/us/podcast/americas-roundtable/id1518878472 Twitter: @DebraLaprevotte @ileaderssummit @AmericasRT @NatashaSrdoc @JoelAnandUSA @supertalk America's Roundtable is co-hosted by Natasha Srdoc and Joel Anand Samy, co-founders of International Leaders Summit and the Jerusalem Leaders Summit. America's Roundtable (https://americasrt.com/) radio program - a strategic initiative of International Leaders Summit, focuses on America's economy, healthcare reform, rule of law, security and trade, and its strategic partnership with rule of law nations around the world. The radio program features high-ranking US administration officials, cabinet members, members of Congress, state government officials, distinguished diplomats, business and media leaders and influential thinkers from around the world. Tune into America's Roundtable Radio program from Washington, DC via live streaming on Saturday mornings via 65 radio stations at 7:30 A.M. (ET) on Lanser Broadcasting Corporation covering the Michigan and the Midwest market, and at 7:30 A.M. (CT) on SuperTalk Mississippi — SuperTalk.FM reaching listeners in every county within the State of Mississippi, and neighboring states in the South including Alabama, Arkansas, Louisiana and Tennessee. Listen to America's Roundtable on digital platforms including Apple Podcasts, Spotify, Amazon, Google and other key online platforms. Listen live, Saturdays at 7:30 A.M. (CT) on SuperTalk | https://www.supertalk.fm

The Art of Charm is brought to you by BetterHelp. Visit betterhelp.com/charm today to get 10% off your first month. Nom Nom delivers fresh dog food with every portion personalized to your  dog's needs, so you can bring out their best. Get 50% off your first two weeks at tryNom.com/artofcharm.  Working out is tough. And finding a workout program that sticks, even tougher. Peloton's classes don't feel like a regular workout class, they feel like entertainment. In fact, you'll be craving your workouts. Get started and download the free Peloton App today. Backed by a leading clinical trial where nine out of ten men experienced healthier and visibly improved skin, Caldera Lab has the tools to unlock your best first impression and confidence! Use code CHARM at calderalab.com for 20% OFF their best products. Factor, America's #1 Ready-To-Eat Meal Kit, can help you fuel up fast with ready-to-eat meals delivered straight to your door. Head to factormeals.com/charm50 to get 50% off your first box. In today's episode, we cover deception and fraud with Chris Chabris. Chris is a research psychologist, Senior Investigator at Geisinger Health System, visiting fellow at the Institute for Advanced Study, and associate professor of Psychology and co-director of the Neuroscience Program at Union College in New York. Scammers and con men are everywhere these days, but how can you recognize when you're being scammed, what behaviors or habits of your own should be aware of that tip you off as a potential victim, and what tactics do scammers, businesses, and governments use on us to get what they want?  What to Listen For Introduction – 0:00 Why are people fascinated by conmen and scammers? How did AJ get scammed in Thailand and what can you learn to avoid being scammed anywhere? How scammers choose their targets – 13:44 What 4 key cognitive habits do scammers exploit in their targets and how can you stop them from exploiting those habits in you? How we help scammers to scam us – 33:50 What do we unconsciously do to help people deceive us? How do people get away with large scale fraud and deception? What are the 4 hooks that businesses and governments use to deceive us? The weapons of scammers – 52:30 How do scammers and con men use words and memories against us? How does your memory deceive you every time you try to remember something? Learn more about your ad choices. Visit megaphone.fm/adchoices

Following the recent 48th Oncology Nursing Society (ONS), Terri Armstrong, the Senior Investigator and Deputy Chief of the Neuro-Oncology Branch at the National Institutes of Health (NIH), sat down with Oncology Data Advisor® to further discuss her translational research regarding better understanding and improving the quality of life of cancer patients.

JEFF NYQUIST, Writer, Epoch Times, Author, “Origins of the Fourth World War and The New Tactics of Global War” and “The Fool and His Enemy,” JRNyquist.blog, @JRNyquist Parallels between the Wagner Group and other “uprisings” in military history What is the end game for the Wagner Group? Assessing the current outlook for the Russian forces Is China paying close attention to the Russia-Ukraine conflict? BILL MARSHALL, Senior Investigator, Judicial Watch A potential problematic relationship between Hunter Biden and Chinese officials How much does the FBI know about payments to the Bidens from Burisma? Is a conviction likely for Hunter Biden? BRIAN O'SHEA, Chief Operating Officer, Centurion Intelligence Partners Was the Wagner Group movement a psychological operation? Is China “further emboldened” by “weakness” in the United States? Analyzing the relationship between Putin and Xi Jinping

Ret. Det. Lindsey Wade is an Author, Podcaster, and a former Tacoma Police Officer with over two decades of experience in law enforcement. Specializing in solving cold cases through the power of DNA, Lindsey has served as a detective, a Senior Investigator for the Washington State Attorney General's Office, and as a member of multiple national investigative associations. In this podcast, Ret. Det. Lindsey Wade joins Jared Bradley and discusses her new book, “In My DNA”, which delves into some of the cases she has solved over her career.   Lindsey reveals the five-year journey it took for her to write and publish the book, and how she had to research the literary industry and learn the process of being an unknown author. Solving cold cases involves facing the bleakest aspects of human behavior. It requires unraveling the worst nightmares that people are capable of inflicting on one another. Yet, Lindsey has dedicated her career to bringing justice to victims and closure to their families. She has often had to rely on the smallest traces of DNA to solve these cases, demonstrating the incredible power of modern forensic science. However, the journey to becoming an author was no less challenging. Lindsey had to learn the ins and outs of the literary industry, a journey that took her five years. Her determination and resilience saw her through, and her book is now a testament to her incredible career and the power of persistence. Takeaways Never forget victims' stories. Link cases to childhood memories. Learn from life's experiences. Connect Lindsey Wade: www.linkedin.com/in/lindsey-w-85033b138 Website: www.lindseywade.org Jared Bradley: https://www.linkedin.com/in/jaredvbra... DNA Retrieval: https://www.m-vac.com/ #Lindsey #Wade #author #detective #homicide #tacoma #murder #stories #InMYDNA All Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time. The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime. Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos. If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel @https://www.youtube.com/c/MVacSystems...

For the riveting finale of this podcast series, Ret. Det. Lindsey Wade joins Jared Bradley once again to delve further into the captivating world of criminal investigations. In this episode, they explore the profound impact of DNA evidence and its pivotal role in solving complex cases.Lindsey Wade shares her extensive expertise and recounts compelling real-life scenarios that highlight the significance of proactive DNA collection. Through thought-provoking cases, she reveals the shocking reality that not all dangerous criminals have their DNA in the database, challenging long-held assumptions and emphasizing the need for comprehensive DNA profiling.One of the remarkable cases discussed is the Mudbit case, where a missing child investigation tragically transforms into a homicide inquiry. As Ret. Det. Lindsey Wade unravels the complexities of the investigation, she reveals how the persistence of law enforcement and the strategic use of DNA evidence ultimately lead to the identification of the perpetrator and the resolution of a heinous crime.These gripping narratives serve as powerful reminders of the unwavering dedication and relentless pursuit of justice required in solving high-profile cases. Ret. Det. Lindsey Wade's insights shed light on the crucial role DNA analysis plays in unraveling mysteries, bringing closure to victims and their families, and ensuring that no crime goes unpunished.Ret. Det. Lindsey Wade is an Author, Podcaster, and a former Tacoma Police Officer with over two decades of experience in law enforcement. Specializing in solving cold cases through the power of DNA, Lindsey has served as a detective, a Senior Investigator for the Washington State Attorney General's Office, and as a member of multiple national investigative associations.TakeawaysDNA evidence is a game-changer.Comprehensive DNA profiling is essential.Empower detectives with the resources they need.ConnectLindsey Wade: www.linkedin.com/in/lindsey-w-85033b138Website: www.lindseywade.orgJared Bradley: https://www.linkedin.com/in/jaredvbradleyDNA Retrieval: https://www.m-vac.comAll Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time. The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime. Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos. If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel @https://www.youtube.com/c/MVacSystems...

In the second episode of the series, Ret. Det. Lindsey Wade rejoins Jared Bradley to delve further into the intricacies of criminal investigations. Her career, ignited by personal experiences and the notorious Ted Bundy case, led her to specialize in solving cold cases through DNA analysis. Wade's stories illuminate her deep-seated passion for justice and a relentless pursuit of truth.The conversation revolves around the pivotal role of the CODIS database. Despite its critical importance, a significant challenge law enforcement faces is the limited number of DNA profiles within the system. Wade advocates for mandatory DNA collection from all convicts to bridge this gap. Even as she acknowledges the potential of investigative genetic genealogy, she emphasizes that efforts should primarily be focused on maximizing the existing CODIS system's efficacy.Wade also shares insights on criminal behavior patterns, noting that individuals often commit a range of offenses. This increases the likelihood of apprehension for non-violent crimes, such as burglary or drug possession.Ret. Det. Lindsey Wade is an Author, Podcaster, and a former Tacoma Police Officer with over two decades of experience in law enforcement. Specializing in solving cold cases through the power of DNA, Lindsey has served as a detective, a Senior Investigator for the Washington State Attorney General's Office, and as a member of multiple national investigative associations.TakeawaysThe CODIS database is a vital tool in criminal investigations.Criminals often engage in a variety of offenses.Crime labs need funding.ConnectLindsey Wade: www.linkedin.com/in/lindsey-w-85033b138Website: www.lindseywade.orgJared Bradley: https://www.linkedin.com/in/jaredvbradley/DNA Retrieval: https://www.m-vac.com/All Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time. The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime. Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos. If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel @https://www.youtube.com/c/MVacSystems...

Ret. Det. Lindsey Wade is an Author, Podcaster, and a former Tacoma Police Officer with over two decades of experience in law enforcement. Specializing in solving cold cases through the power of DNA, Lindsey has served as a detective, a Senior Investigator for the Washington State Attorney General's Office, and as a member of multiple national investigative associations.In this podcast series, Ret. Det. Lindsey Wade joins Jared Bradley and discusses her new book, “In My DNA”, which delves into some of the cases she has solved over her career. Lindsey reveals the five year journey it took for her to write and publish the book, and how she had to research the literary industry and learn the process of being an unknown author.Solving cold cases involves facing the bleakest aspects of human behavior. It requires unraveling the worst nightmares that people are capable of inflicting on one another. Yet, Lindsey has dedicated her career to bringing justice to victims and closure to their families. She has often had to rely on the smallest traces of DNA to solve these cases, demonstrating the incredible power of modern forensic science.However, the journey to becoming an author was no less challenging. Lindsey had to learn the ins and outs of the literary industry, a journey that took her five years. Her determination and resilience saw her through, and her book is now a testament to her incredible career and the power of persistence.TakeawaysNever forget victims' stories.Link cases to childhood memories.Learn from life's experiences.ConnectLindsey Wade: www.linkedin.com/in/lindsey-w-85033b138Website: www.lindseywade.orgJared Bradley: https://www.linkedin.com/in/jaredvbradley/DNA Retrieval: https://www.m-vac.com/All Things Crime is a new, comprehensive video series that will explore every aspect of crime and the ensuing investigation, one video interview at a time. The host, Jared Bradley, is the President of M-Vac Systems, which is a wet-vacuum based forensic DNA collection system, and has experience traveling the world training all levels of law enforcement and crime lab DNA analysts in using the M-Vac to help solve crime. Along the way he has met people from all walks of life and experience in investigating crimes, so is putting that knowledge to use in another way by sharing it in these videos. If you are interested in more videos about the M-Vac, DNA and investigations, also check out the M-Vac's channel @https://www.youtube.com/c/MVacSystems...

JONATHAN EMORD, Constitutional law attorney and author of The Authoritarians: Their Assault on Individual Liberty, the Constitution, and Free Enterprise from the 19th Century to the Present (2021) A recent Supreme Court ruling dealing with Exxon Various abuses of the "administrative state" that the Supreme Court is now aware of How China is targeting various nation-states through financial aid BILL MARSHALL, Senior Investigator, Judicial Watch The National Institutes of Health's (NIH) role in funding the Wuhan Institute of Virology Were the CIA and DoD involved in this funding? Differentiating between bio-warfare and bio-defense RICK GREEN, President, PatriotAcademy.com What is Patriot Academy? What are the LIFT principles? The great importance of educating America's youth about the Constitution

Today, Hunter spoke with Felicia Tempel, Senior Investigator in the Barron County, Wisconsin Public Defender Office. As with all of the episodes covering a smaller Public Defender Offices, today's show is all about understanding the challenges that similarly cash and personnel regions of the country face in trying to create vibrant Public Defense Offices. If you will recall my episode on the lawsuit facing the state of Wisconsin, rural Wisconsin is struggling to get enough resources for contract counsel. As such, there are understandable short falls for the institutional Public Defender Offices as the state seeks to deal with one problem at a time. For the people who the office represent though? Waiting for more resources to come in might not be an option.     Guest:  Felicia Tempel, Senior Investigator, Barron County, Wisconsin   Resources: Barron County Wisconsin PD Office https://howtojustice.org/resources-services/barron-county-public-defenders-office-wi/   Contact Hunter Parnell: Publicdefenseless@gmail.com  Instagram @PublicDefenselessPodcast Twitter                                                                 @PDefenselessPod www.publicdefenseless.com    

On today's episode, Dennis speaks with SCT Instructor of De-Escalation and Crisis Intervention That Actually Works, Jeff Scholz. Jeff is a retired Senior Investigator from the New York State Police with over 24 years of service and over 28 total years of experience in law enforcement. Upon retirement, Jeff was the Senior Investigator for BCI Training at the State Police Academy, responsible for the development, facilitation, and delivery of training programs to over 1,100 NYSP Investigators in the Bureau of Criminal Investigation, (BCI), as well as programs for uniformed Troopers, recruits, civilians, and outside law enforcement agencies. Jeff is certified as a New York State Division of Criminal Justice Services Master Instructor for Police Topics and is a recognized instructor for the Bureau of Justice Assistance Valor program for the Officer Safety and Wellness Initiative. Jeff has now taken a new role in providing quality public safety-oriented programs to public and private entities to help mitigate these threats and founded 886 Consulting, LLC. Jeff talks about de-escalation training and the impact it has on how police officers handle everyday situation and the importance of communication. Today, Dennis and Jeff discuss the tactics of de-escalation, what you will learn and how to apply de-escalation in Jeff's course, the concern and myth of "wokeness" with de-escalation, why de-escalation is smart and safe policing and the importance of treating people with family and empathy to get further in this career. Check out Jeff's upcoming classes here: ⁠https://www.streetcoptraining.com/courses/de-escalation-and-crisis-intervention-that-actually-works/ If you like what you are hearing and want to stay in the loop with the latest in Street Cop Training, please follow our Facebook Page: https://www.facebook.com/StreetCopTraining Don't forget to subscribe and rate the podcast, it truly helps! Sign up for classes here: https://streetcoptraining.com/course-list/Follow our podcast here: https://streetcoptraining.com/street-cop-podcast/    or    https://podcasts.apple.com/us/podcast/street-cop-podcast/id1538474515

David R. Montague is an associate professor of criminal justice at the University of Arkansas at Little Rock and director of the UALR Senior Justice Center which mentors college students while addressing elder crime. Dr. Montague completed federal investigations for fourteen years in law enforcement and intelligence capacities working for the United States Drug Enforcement Administration (DEA) as a federal drug diversion investigator, the United States JFK Assassination Records Review Board (ARRB) as the Senior Investigator, and as a consultant on national security matters with US Investigations Services, Inc.; the largest private investigative company in North America. --- Support this podcast: https://anchor.fm/out-of-the-blank-podcast/support

‘We should not consider Wagner as a traditional mercenary group, but more as a powerful weapon used by Russia and we should all feel threatened by its expansion because it's a rising global threat' -Nathalia Dukhan on the threat posed by the Wagner Group In the latest episode of the Sanctions Space Podcast, Justine is joined by Nathalia Dukhan, Senior Investigator at The Sentry, and Naureen Chowdhury Fink, Executive Director of the Soufan Center. Their discussion takes a closer look at the Wagner Group, including how it contributes to regional insecurity and instability, its level of support and ongoing relationship with the Russian government, and how it uses gold, diamonds and other minerals to self-finance and evade sanctions. They also discuss the financial tools available to counter the Wagner Group, including financial sanctions and the possibility of designating Wagner as a Foreign Terrorist Organization. Nathalia Dukhan is a Senior Investigator at The Sentry, who works on the Central African Republic with a focus on the economic and financial drivers of sectarian violence. Nathalia, with last episode's guest Justyna Gudzowska, recently published a Politico Opinion. Read that here: https://www.politico.com/news/magazine/2023/01/27/russia-wagner-ukraine-biden-terrorist-organization-00079799 Naureen Chowdhury Fink is the Executive Director of The Soufan Center. She previously served Senior Policy Adviser on Counterterrorism and Sanctions at the United Kingdom's Mission to the United Nations, leading representation and negotiations in the Security Council and General Assembly. Prior to that, she has worked with UN Women and the UN Counter-Terrorism Executive Directorate (CTED). Read more here: https://thesoufancenter.org/team/naureen-chowdhury-fink/

#STSNation,Welcome to another episode of Surviving The Survivor, the podcast that brings you the #BestGuests in all of True Crime…It's week three of the double murder trial of embattled former attorney Alex Murdaugh …Murdaugh is accused of killing his wife and youngest son, Maggie and Paul, at the family's Colleton County property in June of 2021.And that's just a fraction of the story. #BestGuests:Joseph Scott Morgan, is the Distinguished Scholar of Applied Forensics at Jacksonville State UniversityMorgan is considered one of the leading experts on the Coroner System in the United Stateswas the Senior Investigator for the Fulton County for close to 15 yearsAlso hosts his own podcast "Body Bags with Joseph Scott Morgan"Gigi Mi-Kelvey is host of the popular true crime podcast Pretty Lies & Alibis. She's also been covering the Alex Murdaugh trial from the get-go for the Law & Crime Network. If you cant watch the trial, she is breaking down testimony every day. Support STS by joining our channel membership or become a patron:Patreon.com/SurvivingTheSurvivor#truecrime #alexmurdaugh #murdaugh #truestory #truecrimecommunity #news #podcast #murdermystery #trial #crime_news #jury #southcarolina

Fintan Butler, ex Senior Investigator, Ombudsman's office, discusses the controversy over the State's nursing home charges legal strategy.

In this episode of The Ethics Experts, Nick welcomes Mara Senn. Mara V.J. Senn is currently a Director and Senior Counsel for Global Compliance Investigations at Zimmer Biomet conducting investigations all over the world with a particular focus on Latin America. She was previously a Senior Investigator and Senior Litigation Specialist at the Integrity Vice Presidency at the World Bank where she investigated allegations of corruption, fraud, collusion, obstruction and coercion in World Bank-financed projects around the world.

BRADLEY THAYER, Director of China Policy, Center for Security Policy, Author, How China Sees the World  What happened at the recent meeting between President Biden and Xi Jinping? Xi's determination to conquer Taiwan The Biden administration's stance on China PRIME MINISTER SALIH HUDAYAR, Founder, East Turkistan Awakening, Prime Minister, East Turkistan Government-in-Exile, @SalihHuayar: Is China's “Zero Covid Policy” impacting their genocidal activity? How Biden's meeting with Xi shows American weakness with respect to China BILL MARSHALL, Senior Investigator, Judicial Watch New data coming out about COVID-19 vaccines Have numbers about the efficacy of the vaccines been manipulated?

On this week's show the boys welcome on one of the leading experts in the Coroner System in the United States and the former Senior Investigator with the Fulton County Medical Examiner, Joseph Scott Morgan. Joseph is now an Associate Professor of Applied Forensics at Jacksonville State University and the host of the podcast Body Bags. They discuss investigating a death through science, people's fascination with serial killers and true crime, the difference between what people see on TV and reality, do serial killers live amongst us, and the most difficult part of being a Medical Examiner. Enjoy the show and Yeah C'mon!   Follow Joseph Scott Morgan on social media:    Twitter: @MedCoLegalDeath Instagram: @JosephScottMorgan    Download Body Bags with Joseph Scott Morgan:    Body Bags with Joseph Scott Morgan on Apple Podcasts    Read his book Blood Beneath My Feet: The Journey of a Southern Death Investigator:    Blood Beneath My Feet: The Journey of a Southern Death Investigator: Morgan, Joseph Scott: 9781936239337: Amazon.com: Books   Find your own bottle of Yeah C'mon Legends Bourbon:    Yeah C'mon Bourbon | Locations (spiritsusa.com)

BILL WALTON, Host, The Bill Walton Show A recent report on the number of surveillance cameras in China How does this report play into China's Social Credit System? What does China do with the data from these cameras? COL. DAVID GIAMMONA (RET.), Chairman and Executive Officer, Battle Ready Ministries Multiple "levels" of conflict that United States finds itself currently in Are "deep-state operatives" trying to divide the U.S.? BILL MARSHALL, Senior Investigator, Judicial Watch What is the concept of "intersectionality"? A use of "race warfare" by the American Left

COL. (RET.) JOHN MILLS, Senior Fellow, Center for Security Policy, Member, Committee on the Present Danger: China A new development with respect to the China-Taiwan relationship The Chinese "colonial buildout" of their presence around the world BILL MARSHALL, Senior Investigator, Judicial Watch Judicial Watch's work with respect to the FBI raid on Mar-a-Lago Increased weaponization of the FBI in recent years AMB. PETE HOEKSTRA, former Congressman (1993-2011), Michigan's 2nd Congressional District, former US Ambassador to the Netherlands (2017-2021), Fellow, Center for Security Policy, @Petehoekstra Does the Biden administration understand the threats facing America? How has the U.S. withdrawal from Afghanistan impacted terrorism in the region?

On today's episode, Dennis speaks with retired NY State Trooper, Jeff Scholz. Jeff is a retired Senior Investigator from the New York State Police with over 24 years of service and over 28 total years of experience in law enforcement. Upon retirement, Jeff was the Senior Investigator for BCI Training at the State Police Academy, responsible for the development, facilitation, and delivery of training programs to over 1,100 NYSP Investigators in the Bureau of Criminal Investigation, (BCI), as well as programs for uniformed Troopers, recruits, civilians, and outside law enforcement agencies. Jeff is certified as a New York State Division of Criminal Justice Services Master Instructor for Police Topics and is a recognized instructor for the Bureau of Justice Assistance Valor program for the Officer Safety and Wellness Initiative. Jeff has now taken a new role in providing quality public safety-oriented programs to public and private entities to help mitigate these threats and founded 886 Consulting, LLC. Jeff talks about de-escalation training and the impact it has on how police officers handle everyday situation and the importance of communication. If you like what you are hearing and want to stay in the loop with the latest in Street Cop Training, please follow our Facebook Page: https://www.facebook.com/StreetCopTraining

STEPHEN BLANK, Senior Fellow for Russia at the American Foreign Policy Council How can the West continue supporting Ukraine? Dr. Blank explains what Putin wants BILL MARSHALL, Senior Investigator, Judicial Watch Marshall talks about an FBI probe concerning the Wuhan COVID lab How Critical Race Theory is affecting American education KEVIN FREEMAN, Host, Economic War Room, Senior Fellow, Center for Security Policy, Author, “Game Plan: How to Protect Yourself from the Coming Cyber-Economic Attack” and “Secret Weapon: How Economic Terrorism Brought Down the U.S. Stock Market and Why It Can Happen Again,” Founder, Globaleconomiwarfare.com, @SecretWeaponUSA: Is BlackRock's Chinese subsidiary influenced by the CCP? Freeman explains how private markets hide good ideas from the average investor

STEVEN MOSHER, President, Population Research Institute, Author, “Bully of Asia: Why China's Dream is the New Threat to the World,” @StevenWMosher Genocide taking place in China An update on U.S.-Chinese relations Various ways Xi Jinping controls Chinese citizens' lives CINDY DRUKIER, Veteran journalist, editor, and producer, Host of NTD's The Nation Speaks featured on EpochTV Drukier previews a new film by NTD on the origin of COVID-19 BILL MARSHALL, Senior Investigator, Judicial Watch New reporting on the origins of COVID-19 CRT being taught in American service academies

GRANT NEWSHAM, Senior Fellow, Center for Security Policy, Senior Research Fellow, Japan Forum for Strategic Studies, Contributor, Asia Times, @NewshamGrant China's desire to kick the U.S. out of Asia and dominate the world The need for the U.S. to be on the defensive against the CCP PETER PRY, Executive Director, Task Force on National and Homeland Security, Director, U.S. Nuclear Strategy Forum, Former Member, Congressional EMP Commission, the Congressional Strategic Posture Commission, the House Armed Services Committee, and the CIA Does Iran already have a nuclear bomb? The need to protect the Texas electric grid BILL MARSHALL, Senior Investigator, Judicial Watch Updates on the Sussman-Durham trial Other work Judicial Watch is doing in the world of FOIA requests