Podcasts about manufacture

Neoborn Caveman lets loose a marble-mouthed satirical ramble on who gets to rule whom. He starts on Operation Banner, the British army on the streets of Northern Ireland from 1969, and on a government that treats Magna Carta as expired. From there NC looks at Defense Secretary William Cohen's 1997 admission that the United States has the means to steer weather, earthquakes and volcanoes, at Hurricane Sandy's 2012 left turn into New Jersey, and at Kings Mountain, North Carolina — lithium in the ground, a Pentagon supply deal, then the floods. After that Neoborn turns to ENMOD, Project Popeye over the Ho Chi Minh Trail in 1967, HAARP, and the 1977 UN ban on hostile environmental modification that the United States and the Soviet Union both signed. Later he takes the flattering story every nation tells about the day it began to school its children. NC then investigates Horace Mann's Prussian model, Massachusetts compulsory school in 1852, and Rockefeller's General Education Board from 1902. He closes on the manufacture of obedience, and finally on the question he will not let go of: why don't we want to be free?Music guests: Big Sexy, DAV-EL, Carlyle, Reverend Genes00:00:00 On This Day Today - Operation Banner00:20:48 Big Sexy: This City Knows My Face00:24:36 William Cohen, Hurricane Sandy, and the Kings Mountain Floods00:28:54 DAV-EL: Lost In Your Love00:32:26 ENMOD, HAARP, and the UN Ban on Environmental Warfare00:48:43 Carlyle: Without the Weed00:52:33 The Manufacture of Obedience01:07:44 Reverend Genes: Everyday PeopleKey TakeawaysOperation Banner put British soldiers on the streets of Northern Ireland. Military at home is not police work.In 1997 Defense Secretary William Cohen said the United States already had the technology to control weather, including earthquakes and volcanoes.Kings Mountain, North Carolina sits on one of the largest identified lithium deposits in the country. The same ground took the floods.In 1977 the UN banned hostile environmental modification. The United States and the Soviet Union signed it.There was a time no American law required a child to go to school, and the country that skipped the requirement read better than most of the empires that enforced it.Horace Mann brought the Prussian model home. Massachusetts made attendance compulsory in 1852. By 1918 every state had followed.Rockefeller's General Education Board, founded 1902, funded a school meant to fit each student into a slot already cut for him.The child who reads to satisfy his own conscience answers inside himself. The child who memorizes for an examiner answers outside himself.Sound Bites“Am I a hack? Hopefully not. Well, I am more real and authentic than your government.”“Military, domestically, is not the solution. Ever.”“He who controls the weather will control the world.”“The evidence can be proved only by the same people who cause the problem.”“I have nothing to hide so I am not going to show you.”“Idiot in Greek means not taking part meaningfully in political and other decision making.”“It's my water, it's your water, dear listeners.”“Truth starts when you are ridiculed.”“The modern school was built to order a mind rather than open one.”“It's not benevolent, it's man-evolent what is happening to us.”“Why don't we want to be free?”The tea house is at patreon.com/theneoborncavemanshow. Sit down. Support the work. Stay real. Remember: you are worthy, you are amazing, you are one of a kind! Humanity centered satirical takes on the world & news + music - with a marble mouthed host.Free speech marinated in comedy.Supporting Purple Rabbits.Viva los Conejos Morados. Hosted on Acast. See acast.com/privacy for more information.

À Saint-Denis, une ancienne manufacture Christofle est devenue un lieu dédié aux métiers d'art. Une douzaine d'entreprises y perpétuent des savoir-faire d'exception, entre patrimoine industriel et artisanat contemporain. Victor Gazzola, directeur général de la menuiserie et ébénisterie d'art Maleville, nous ouvre les portes de L'Orfèvrerie.En savoir plus : https://www.lorfevrerie.fr/Reportage réalisé par Jean-Christophe Nurbel.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

La dernière fois que nous nous étions laissés, nos protagonistes venaient tout juste d'entrer par infraction chez Securi-Pieux, une entreprise de construction. Est-ce qu'ils trouveront des indices importants sur le rituel étrange qu'ils ont découvert? Allons rejoindre :David Rickard, le représentant en vente pyramidale, joué par Ian Richards;Valérien St-Laurent, le haut dirigeant de la Canadian Steamship Line, joué par Jonathan Papin;Victor Slither, le psychothérapeute, joué par Jean-Philippe Décarie-Mathieu;Adrien Cara, le mécène artistique propriétaire de la Manufacture, joué par Antoine Biron;Marcel Richmond, le faux médium charlatan et ancien entrepreneur dans le milieu du propane, joué par Martin Durette.Votre maître de jeu est Benoit Gagnon.Crédit musique d'ambiance : ⁠⁠⁠⁠⁠⁠https://pixabay.com/users/welbornworks-27363706/⁠⁠⁠⁠⁠⁠Cet épisode est rendu possible grâce à :Eric OlivierFrancis TremblayMathieu GélinasNicolas HouleLe CanardPier-Luc DeschampsGuillaume BoivinFrederic Roy-LegrosUne pouliche on peut tu laisser ça dans cour?

Why is gene therapy still so difficult to manufacture at scale after decades of progress?Phillip Ramsey, Chief Technical Officer at Sangamo Therapeutics, joins BioTalk Unzipped for a candid conversation about one of the central challenges facing advanced therapies: turning extraordinary science into reproducible, scalable medicines.Thank You to Our SponsorsLeucentra - https://leucentra.com/Inspired by Science. Empowered by IT. Leucentra provides specialized IT consulting and services for life sciences and healthcare, helping organizations use technology more effectively to support innovation.TruTechnologies - https://trutechnologies.ai/Clinical Trial Execution, Live. TruTechnologies provides live clinical trial execution technology that gives sponsors greater visibility into protocol activities, samples, and study data as they happen.About This EpisodeRecorded onsite at the AAPS National Biotechnology Conference in Boston, Phillip explains why gene therapy manufacturing has not yet reached the maturity of monoclonal antibody production.As technologies have evolved across retroviral vectors, lentiviral vectors, adenovirus, AAV, lipid nanoparticles, and other advanced modalities, development teams have repeatedly been required to rethink fundamental manufacturing and analytical questions.Phillip discusses why analytics are critical, why experience across multiple manufacturing lots and products matters, and why there simply is no shortcut to developing the scientific knowledge necessary to manufacture advanced therapies reliably.He also reflects on the uncertainty of biotechnology.Early in his career, Phillip was walking down a hallway when his CFO asked if he had cashed his paycheck.When he said no, she told him not to.It's a remarkable story that captures something rarely discussed about biotechnology: behind transformative science are people willing to operate through considerable uncertainty while trying to build something that has never existed before.Gregory and Phillip Discuss• Viral vector manufacturing and scale-up• Why analytics are essential to gene therapy development• AAV manufacturing challenges• Lentiviral vectors and other evolving delivery technologies• Lipid nanoparticles and changes in advanced therapy manufacturing• Why gene therapy cannot simply adopt the established monoclonal antibody manufacturing playbook• Building process knowledge across lots and products• Career resilience in biotechnology• Progress across AAV, CAR-T, and other advanced therapies• Gene therapy affordability• The importance of therapeutic durability• Outcomes-based payment models for advanced therapiesPhillip's message for scientists and industry leaders is straightforward: don't assume the manufacturing problem has already been solved simply because a technology has existed for decades.The field is still evolving, and some knowledge cannot be shortcut.About Phillip RamseyPhillip Ramsey is Chief Technical Officer at Sangamo Therapeutics and brings more than 35 years of experience across biotechnology and pharmaceutical manufacturing, technical development, operations, quality, and advanced therapies.Connect with Phillip Ramsey:https://www.linkedin.com/in/phillip-ramsey-a2074711/Sangamo Therapeutics:https://www.sangamo.com/Connect With BioTalk UnzippedGregory Austin on LinkedIn:https://www.linkedin.com/in/gregoryaustin1/Dr. Chad Briscoe on LinkedIn:https://www.linkedin.com/in/chadbriscoe/BioTalk Unzipped:https://www.biotalkunzipped.com/BioTalk Unzipped unzips, unlocks, and uncovers the stories behind medical progress through conversations with scientists, executives, entrepreneurs, and innovators advancing biotechnology, pharmaceuticals, and medical technology.Recorded onsite at the AAPS National Biotechnology Conference in Boston.Special thanks to AAPS and Rebecca Stauffer for supporting the BioTalk Unzipped interview series.

Lors du dernier épisode, nos protagonistes se sont vus impliqués dans une enquête portant sur un meurtre étrange, semblant impliquer des rituels oubliés. Est-ce que nos anti-héros vampiriques ont des capacités d'enquête dans le sang? Allons rejoindre :David Rickard, le représentant en vente pyramidale, joué par Ian Richards;Valérien St-Laurent, le haut dirigeant de la Canadian Steamship Line, joué par Jonathan Papin;Victor Slither, le psychothérapeute, joué par Jean-Philippe Décarie-Mathieu;Adrien Cara, le mécène artistique propriétaire de la Manufacture, joué par Antoine Biron;Marcel Richmond, le faux médium charlatan et ancien entrepreneur dans le milieu du propane, joué par Martin Durette.Votre maître de jeu est Benoit Gagnon.Crédit musique d'ambiance : ⁠⁠⁠⁠⁠https://pixabay.com/users/welbornworks-27363706/⁠⁠⁠⁠⁠Cet épisode est rendu possible grâce à :Eric OlivierFrancis TremblayMathieu GélinasNicolas HouleLe CanardPier-Luc DeschampsGuillaume BoivinFrederic Roy-LegrosUne pouliche on peut tu laisser ça dans cour?

Renovating can build equity – but it can also destroy your budget. From hidden costs to builder blowouts and expensive mistakes, here's what every property investor should know before picking up the hammer. On The Smart Property Investment Show, Liam Garman and Emilie Lauer unpack the reality of renovating an investment property, using Emilie's own project as a case study. The pair discuss the hidden costs that caught her by surprise, why quotes aren't always as straightforward as they seem, and the importance of planning for the unknown with a healthy contingency buffer. They also explore how renovations can create manufactured equity in today's market, the decisions that can add long-term value, and why having the right renovation strategy is just as important as choosing the right property. The conversation also shares practical lessons from the renovation process, including how to prepare before work starts, avoid costly oversights, and keep a project on track without losing sight of the bigger investment picture. If you like this episode, show your support by rating us or leaving a review on Apple Podcasts and by following Smart Property Investment on social media: Facebook, X (formerly Twitter) and LinkedIn. If you would like to get in touch with our team, email editor@smartpropertyinvestment.com.au for more insights, or hear your voice on the show by recording a question below.

Nous sommes à Montréal. Nos protagonistes seront confrontés à un événement qui pourrait déstabiliser la Mascarade. Comment nos vampires incompétents s'assureront de maintenir le secret de leur organisation? Allons rejoindre :David Rickard, le représentant en vente pyramidale, joué par Ian Richards;Valérien St-Laurent, le haut dirigeant de la Canadian Steamship Line, joué par Jonathan Papin;Victor Slither, le psychothérapeute, joué par Jean-Philippe Décarie-Mathieu;Adrien Cara, le mécène artistique propriétaire de la Manufacture, joué par Antoine Biron;Marcel Richmond, le faux médium charlatan et ancien entrepreneur dans le milieu du propane, joué par Martin Durette.Votre maître de jeu est Benoit Gagnon.Crédit musique d'ambiance : ⁠⁠⁠⁠https://pixabay.com/users/welbornworks-27363706/⁠⁠⁠⁠Cet épisode est rendu possible grace à :Eric OlivierFrancis TremblayMathieu GélinasNicolas HouleLe CanardPier-Luc DeschampsGuillaume BoivinFrederic Roy-LegrosUne pouliche on peut tu laisser ça dans cour?

Building a cell therapy company is hard. Building a genetically engineered iPSC therapy for the brain, on a preclinical budget, is one of the hardest translational problems in biotech. Every experiment has to move the program closer to an IND, or it's motion without progress.That's the operating constraint Bilal Fares faces as CEO and co-founder of AzureCell, the University of Geneva spin-off engineering neuroprotective iPSC neurons for Parkinson's disease. In Part 2, he walks through how his team decides what to build, where AI and synthetic biology genuinely accelerate a CMC roadmap, and the four founder lessons he wishes he'd internalized earlier, including his conviction that scientists who use AI will replace those who don't.Topics discussed include:Strategies for prioritizing experiments and narrowing focus with limited resources (03:33)How business opportunity validation programs helped define a product roadmap (04:08)Integrating AI and synthetic biology into research programs—and where these tools do, and don't, accelerate development (05:07)Building a cell therapy platform for personalized approaches in neurological diseases beyond Parkinson's (06:38)Lessons learned in biotech leadership and why tackling big problems matters (08:08)Key advice for aspiring biotech entrepreneurs: kill your own solutions quickly, and learn from others (09:27)The importance of having a strong team and how a powerful mission attracts top talent (12:21)AzureCell's near-term plans and future goals, including upcoming fundraising and R&D milestones (13:30)Smart insight: What separates successful biotech ventures from the rest? According to Bilal Fares, it is not just technical skill but mindset. First, choose a problem large enough to be worth the struggle. Second, try to “kill your solution as fast as possible”—engage experts, enter competitions, and seek brutal feedback early so you can pivot, improve, or abandon as needed. And finally, plan with the end (approval, patients, impact) always in sight.If you enjoyed this, check out these episodes on cell therapy, where engineered cells can survive and do more than replace what's lost: Michael Rome's investor lens rounds it out for founders facing the same funding realities.Episodes 269 - 270: How to Turn Mesenchymal Stem Cells into Programmable Cancer Delivery Vehicles with Jun Yung WooEpisodes 253 - 254: How to Source, Manufacture, and Scale the Earliest Stem Cells for Allogeneic Cell Therapy Without Ethical Barriers with Yuta LeeEpisodes 249 - 250: How T Cell Activation Redefines TIL and CAR-T Manufacturing (Boosting Success Rates to 95%) with Chantale BernatchezEpisodes 259 - 260: Why Strong Science Isn't Enough to Get Funded: What Investors Actually Look For with Michael RomeConnect with Bilal Fares:LinkedIn: www.linkedin.com/in/b-fares AzureCell website: www.azurecell.co Email: info@azurecell.coSupport the show

On this episode of 3:12 we were joined by Zaid Zulqarnain of Spectra Scientific, to share their story of transformation, from a small equipment rental company to the creators of innovative field tech and equipment. Make sure to use code: HRP at checkout for your next Spectra purchase!      A reminder that our Play Hard segment is also available in video form! Watch that on our YouTube Channel. Make sure you subscribe, give us a review & check us out on social media!YouTubeLinkedInInstagramTwitterFacebookWebsite

Ground News bills itself as a way to evaluate bias in the news, but the way it does so plays into the hands of those who have a reason to make you think all news bias falls into a simple left-right spectrum Bibliography: https://literatemachine.com/2026/07/29/ground-news-and-the-war-on-reality/#bibliography  Text version: https://literatemachine.com/2026/07/29/ground-news-and-the-war-on-reality/ Support this channel at https://patreon.com/ericrosenfield and get early, ad-free episodes and more for only $1, including the bonus chapter to this episode about Walter Lippmann ("The Manufacture of the Manufacture of Consent"): https://www.patreon.com/ericrosenfield/posts/manufacture-of-164895857 Thanks to all my patrons! Support some journalism coops: * 404 Media: https://www.404media.co/ * Defector: https://defector.com/ * Aftermath: https://aftermath.site/ * RANGE Media: https://www.rangemedia.co/ * Hell Gate: https://hellgatenyc.com/ * Flaming Hydra: https://flaminghydra.com/

Ep 296 Peacewarts: Resonant Charms - The False Consensus Detector (Class 12) In class 12, we provide a toolkit to identify "Astroturfing" and protect dissenting voices. We compare the "Minority Opinion" in Alcoholics Anonymous—a structural safeguard against mob rule—with the manufactured consensus of the Global Climate Coalition. We cover the "Three Signatures" of artificiality and introduce tactical room defenses like "Round-Robin Speaking" and the "Right of Appeal." Homework: Look up AA's "Right of Appeal" or the history of "Operation Earnest Voice." Write down one question about any of this episode's topics. If you don't have a question, write 'no question.' Optional: Journal about the experience of being a minority voice in a group. Books: If you'd like to read more on this subject, some book suggestions areThink Like a Commoner: A Short Introduction to the Life of the Commons by David Bollier, which outlines how true community consensus operates and provides an excellent lens for spotting artificial, corporate, or manufactured enclosures of agreement, and Toxic Sludge Is Good for You: Lies, Damn Lies and the Public Relations Industry by John Stauber and Sheldon Rampton, a foundational, sharp look at how public relations firms systematically manufacture fake grassroots movements. Learning Topics: Astroturfing; AA's Minority Opinion; The Right of Appeal; The Global Climate Coalition; The Three Signatures of Manufacture; The Micro-Majority Illusion; Operation Earnest Voice. Join the Community / Get the Books:AvisKalfsbeek.com Podcast Music: Javier Peke Rodriguez “I am late, madame Curie”https://javierpekerodriguez.bandcamp.com/

Transplant iPSC-derived neurons into a Parkinson's brain and 97% die before they can restore function. Of the 3% that survive, most face the same pathogenic environment that killed the original neurons. This is the compounded biology and CMC problem defining CNS cell therapy today.Bilal Fares, neuroscience entrepreneur and co-founder of AzureCell, is translating a University of Geneva discovery into a genetically engineered iPSC platform built to solve it: neurons that don't just replace what Parkinson's destroyed, but survive the fire that destroyed them.Topics discussed:Why Bilal believes cell therapy is the future of medicine for brain diseases, and the limitations of other approaches (03:06)Bilal's personal story and the events that guided his commitment to Parkinson's research and entrepreneurship (04:03)How cell therapy might move beyond simply replacing lost neurons—using engineered cells to produce therapeutics directly in the brain (09:05)The neuroprotective technology AzureCell is developing, designed to shield transplanted neurons from Parkinson's disease mechanisms (11:31)The platform approach: combining stem cell technologies, genetic engineering, and allogeneic off-the-shelf cell banks (12:38)Why the blood-brain barrier makes cell therapy a necessary approach for certain conditions (13:26)The current status of Azure's preclinical and manufacturing development, and their plans for clinical translation (14:31)Why previous therapies for Parkinson's have fallen short, and how cell therapy might sidestep these limitations (15:57)The potential and challenges of using cell therapy for other brain diseases like Alzheimer's (18:26)Smart insight: The next generation of CNS cell therapy isn't only about neuron replacement. Bilal's thesis reframes transplanted cells as engineered biological factories inside the brain: producing neuroprotective proteins, modulating disease mechanisms in real time, and eventually enabling preventative treatment as manufacturing costs fall and safety matures.If you enjoyed this, check out these episodes on cell therapy, where engineered cells can survive and do more than replace what's lost: Michael Rome's investor lens rounds it out for founders facing the same funding realities.Episodes 269 - 270: How to Turn Mesenchymal Stem Cells into Programmable Cancer Delivery Vehicles with Jun Yung WooEpisodes 253 - 254: How to Source, Manufacture, and Scale the Earliest Stem Cells for Allogeneic Cell Therapy Without Ethical Barriers with Yuta LeeEpisodes 249 - 250: How T Cell Activation Redefines TIL and CAR-T Manufacturing (Boosting Success Rates to 95%) with Chantale BernatchezEpisodes 259 - 260: Why Strong Science Isn't Enough to Get Funded: What Investors Actually Look For with Michael RomeConnect with Bilal Fares:LinkedIn: www.linkedin.com/in/b-fares AzureCell website: www.azurecell.co Email: info@azurecell.coSupport the show

After the pandemic-era run on medical gloves, the US government set a plan in motion to reshore manufacturing. Roughly six years and almost $1 billion later, America is once again facing potential shortages of medical gloves because of supply chain disruptions stemming from the war in Iran. On today’s Big Take podcast, host Sarah Holder and health care industry reporter Anna Edney break down why US efforts to make American medical gloves have largely failed, what it says about reshoring manufacturing writ large and where the industry goes from here. Read more: Almost $1 Billion Later, the US Still Can’t Make a Medical Glove We have a special Bloomberg subscription offer for podcast listeners at Bloomberg.com/podcastoffer. Hosted by Sarah Holder; Produced by Laura Newcombe and Rachael Lewis-Krisky; Reported by Anna Edney; Edited by Naomi Shavin. Fact-checking by Victor Swezey; Engineering by Sean Carter. Senior Producer: Naomi Shavin; Deputy Executive Producer: Julia Weaver. Executive Producer: Nicole Beemsterboer.See omnystudio.com/listener for privacy information.

After the pandemic-era run on medical gloves, the US government set a plan in motion to reshore manufacturing. Roughly six years and almost $1 billion later, America is once again facing potential shortages of medical gloves because of supply chain disruptions stemming from the war in Iran. On today’s Big Take podcast, host Sarah Holder and health care industry reporter Anna Edney break down why US efforts to make American medical gloves have largely failed, what it says about reshoring manufacturing writ large and where the industry goes from here. Read more: Almost $1 Billion Later, the US Still Can’t Make a Medical Glove We have a special Bloomberg subscription offer for podcast listeners at Bloomberg.com/podcastoffer. Hosted by Sarah Holder; Produced by Laura Newcombe and Rachael Lewis-Krisky; Reported by Anna Edney; Edited by Naomi Shavin. Fact-checking by Victor Swezey; Engineering by Sean Carter. Senior Producer: Naomi Shavin; Deputy Executive Producer: Julia Weaver. Executive Producer: Nicole Beemsterboer.See omnystudio.com/listener for privacy information.

In the biotech industry, advancing cell-based therapies is not just about innovation. It's about solving real gaps where conventional treatments fall short, especially against complex, aggressive tumors.In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann welcomes Jun Yung Woo, Co-Founder of AGEM Bio, who offers an in-depth look at the science and strategy behind engineered mesenchymal stem cells (MSCs), with a focus on why glioblastoma is the right proving ground for the platform.Topics discussed:Why glioblastoma is the right Phase I indication: infiltrative growth, immunosuppression, and STING pathway deficiencies that make GBM uniquely suited to the platform (02:43)The surgical workflow: intracavity MSC delivery during tumor resection, oral 5-FC administration, and how engineered cells act as local bioreactors in the resection cavity (04:05)Mechanisms by which engineered MSCs target heterogeneous and invasive tumors through shared vulnerabilities rather than antigen recognition (05:58)Overcoming immune rejection with allogeneic therapies and the unique immunological profile of MSCs (07:32)Manufacturing and scale-up: addressing donor variability, GMP production, and building a reproducible process (09:16)Why GMP manufacturing should be designed in from the earliest stages of research (10:50)Beyond glioblastoma: expanding the platform to other solid tumors, regenerative medicine, and chronic inflammatory disease (11:27)Strategies for international trial expansion and partnerships beyond Singapore (12:41)Reframing MSCs from stem cell therapy to programmable delivery platform: the MSC 2.0 thesis (14:10)Smart insight: The shift Jun Yung articulates is from treating stem cells as the therapy to treating them as programmable therapeutic vehicles. Once you can reliably engineer, manufacture, and preserve their function, the limitation is no longer what the cell naturally does. It becomes what biology you can encode into it. Glioblastoma is the proving ground, and the platform's reach extends to liver cancers, sarcomas, peritoneal malignancies, and chronic inflammatory disease.These episodes expand on the same themes of MSC biology, cell engineering, and the challenges of scaling consistent, functional cell therapies:Episodes 179 - 180 : How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay DaviesEpisodes 253 - 254: How to Source, Manufacture, and Scale the Earliest Stem Cells for Allogeneic Cell Therapy Without Ethical Barriers with Yuta LeeEpisodes 125 - 126: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon ShareiEpisodes 129 - 130: Revolutionizing Cell Therapy Manufacturing: Reducing Costs to Reach More Patients with Jason FosterConnect with Jun Yung Woo:LinkedIn: www.linkedin.com/in/junyungwooAGEM Bio website: www.agem.bioEmail: yung@agem.bioSupport the show

Salvation comes from God and humanity cannot create it.

What if the answer to solid tumor therapy isn't about making immune cells smarter—but about rethinking what a therapeutic cell can do For years, mesenchymal stem cells (MSCs) have turned heads for their ability to home in on damaged tissue, yet their clinical utility has lagged behind the hype. What would it take to transform MSCs from passive healers into precision vehicles for next-generation cancer treatment?This week, David Brühlmann sits down with Jun Yung Woo, Co-Founder of AGEM Bio, who's devoted nearly two decades to decoding and reimagining the potential of MSCs. From engineering stress-resilient cells to pioneering dual-payload therapeutic platforms, Jun Yung Woo bridges fundamental biology and real-world clinical translation.Topics discussed:The case for understanding cell biology before focusing on process scale-up in bioprocessing (02:38)Jun Yung Woo's personal and scientific journey toward developing engineered MSC therapeutics (04:36)How MSCs sense their environment and exert therapeutic effects via secreted factors, rather than tissue replacement (08:28)Key differences between MSC therapies and immune cell therapies like CAR T cells (10:35)Overview of non-viral engineering platforms, and the importance of intracellular trafficking for modifying MSCs (12:23)Design of AGEM Bio's dual-payload MSC product (cytosine deaminase and interferon beta) to induce highly localized tumor stress and immune activation (14:10)Strategies for controlling MSC targeting and minimizing off-target effects, including the use of prodrug activation and localized cell delivery (17:23)Study results from treating companion animals with engineered MSCs, and observations of tumor regression and possible signs of immune memory (20:29)Open questions about the durability of antitumor responses and future directions for clinical research (22:34)Smart insight: Jun Yung Woo challenges the rush toward bioprocess scale-up, arguing that a deeper understanding of cellular biology should come before manufacturing cells at scale. This episode explores how scaling the wrong biology can derail entire therapeutic platforms—and why aligning process development with cellular function may be critical for clinical success.These episodes expand on the same themes of MSC biology, cell engineering, and the challenges of scaling consistent, functional cell therapies:Episodes 179 - 180 : How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay DaviesEpisodes 253 - 254: How to Source, Manufacture, and Scale the Earliest Stem Cells for Allogeneic Cell Therapy Without Ethical Barriers with Yuta LeeEpisodes 125 - 126: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon ShareiEpisodes 129 - 130: Revolutionizing Cell Therapy Manufacturing: Reducing Costs to Reach More Patients with Jason FosterConnect with Jun Yung Woo:LinkedIn: www.linkedin.com/in/junyungwooAGEM Bio website: www.agem.bioEmail: yung@agem.bioSupport the show

This week we are joined by Rachel Slade to discuss her book Making It In America which examines the story of the company American Roots which has undertaken the nearly impossible task of manufacturing garments 100% made in the U.S.A. Recorded live at the 18th Annual Sustainability Business and Design Conference at the Fashion Institute of Technology in 2024, our discussion centers around the challenges faced by American makers. Learn more about your ad choices. Visit megaphone.fm/adchoices

a discussion surrounding the “Metascript,” a framework used to analyze how governments and power elites exert control by hijacking history and simulating news events. The speaker argues that the news cycle is a “house of cards” built on decades of “history bending,” where simulated events are used to create a singular worldview that legitimizes authority. This analysis is applied to recent events like the staged assassination of Charlie Kirk and the Montreal shooting, which are characterized as manufactured “PsyOps” designed to “pre-sell” the public on future social changes, such as internet censorship and digital IDs.List of Topics* The Metascript and Pattern Literacy: Understanding the continuous, structural script upon which all fake events occur.* Predictive and Concurrent Programming: How movies and media (e.g., The Boys, The Tempest, Sinners) foreshadow real-world simulated events.* The Manufacture of “Woke Right” Extremism: Analyzing the Montreal shooter and his manifesto as a “J-Pill” caricature designed to demonize specific demographics.* Crisis Acting and “Lifetime Actors”: The role of individuals like Charlie and Erica Kirk in performing scripted personas on the world stage.* “Disease X” and the Mind Virus: The narrative of dangerous ideas as viruses to justify internet “quarantines” and lockdowns.* Racialized Martyrs: The use of the Henry Novak and Austin Metcalf cases to fuel “White Lives Matter” sentiment through timed media coordination.5 Quotes from the Sources* “Governments taking control over history and using this to create a singular worldview that justifies, legitimizes, and maybe even gives a divine mandate to their authority.”* “You can no longer rely on the visual deconstruction to say something is fake... you have to have a better form of assessment.”* “Predictive programming is a form of foreshadowing its purposes are... pre-selling us on future fake events so that we get involved in the event rather than... get stuck on the question of is it real.”* “Once you see a mind virus, it signifies that you're aware of these things and how they work... a mind virus is essentially an unsubstantiated belief.”* “I advocate here for, we foment here, a culture of disbelief... If the facts don't support knowing it to be true, I will remain an informed disbeliever.”SummaryThe sources present a theory that global events are no longer organic, but rather carefully choreographed performances designed to guide public response through “guardrails”. By identifying “common denominators” across media and news—such as the specific neck and heart wound locations found in movies like Snake Eyes and Sinners—the speaker claims to expose a manufactured future. Key examples include the Montreal shooter's manifesto, which is viewed as an AI-generated tool to create fear of the “woke right,” and the Henry Novak death, which is linked to symbolic imagery on The Economist covers and movie plots to launch specific political movements. Ultimately, the sources advocate for “pattern literacy” to see through these PsyOps and recognize the structural collusion between government, entertainment, and news media. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit infiniteplanesociety.substack.com/subscribe

Fabian Alefeld interviews Omar Mireles, Director of Manufacture and Materials at Space Nuclear Power Corporation (Space Nukes), about his career spanning NASA, Oak Ridge, and Los Alamos and how additive manufacturing (AM) reshaped space hardware development. Omar describes early exposure to SLS prototyping, graduate work in nuclear materials and propulsion, building nuclear materials labs at NASA Marshall, and later leading AM efforts for liquid rocket engines and refractory metals.  He explains how AM accelerates iteration, enables complex geometries, part consolidation, and weight reduction, and where traditional methods still dominate depending on production rate. The conversation covers refractory metal challenges (supply chain, oxygen sensitivity, post-processing, inspection) and nuclear reactor basics, generations, and regulatory barriers to AM adoption. Omar outlines Space Nukes' goal of delivering safe, affordable, reliable power anywhere in the solar system, noting heat rejection as a key space constraint, Krusty's 2018 test heritage, potential AM roles in heat exchangers, and an aggressive ~2-year flight timeline depending on regulation and mission. 02:26 Omar Early Motivation 03:08 NASA Co-ops and First AM 07:59 Stirling Radiation Research 20:07 Refractory Metals AM Lab 21:31 Los Alamos to Space Nukes 25:14 Did AM Change Space Race 31:46 Where AM Flies Today 37:41 Rocket Engines Print vs Traditional 41:15 Refractory Alloys Challenges 46:39 Where Refractories Make Sense 47:05 Will Refractory AM Grow 49:39 NASA Metal AM Handbook Origins 56:37 How Nuclear Reactors Work 01:13:02 Additive Manufacturing in Nuclear 01:18:31 What Space Nukes Builds 01:19:36 Why Space Nuclear Power Matters 01:25:20 Why Space Needs Nukes 01:37:47 Krusty Test Proof 01:41:18 Heat Rejection Challenge 01:49:25 Timeline and First Missions 

In this episode of Sanity Check, David Legates examines a Guardian article claiming that U.S. immigration enforcement flights carry a "huge climate cost." Looking beyond the headline, he compares the reported emissions with total U.S. greenhouse gas emissions, aviation emissions, and other major sources to ask whether the article's conclusions are supported by meaningful context. Along the way, he discusses media framing, statistical significance, selective comparisons, and how climate narratives are increasingly woven into debates over public policy. The episode argues that informed discussion requires proportion, historical perspective, and careful interpretation of the numbers—not simply dramatic headlines.https://www.theGuardian.com/us-news/2026/may/26/us-immigration-flights-emissionshttps://www.statista.com/statistics/183943/us-carbon-dioxide-emissions-from-1999/https://cis.org/Report/Immigration-United-States-and-WorldWide-Greenhouse-Gas-Emissionshttps://clivebest.com/blog/?p=11131Visit our podcast resource page: https://cornwallalliance.org/listen%20to%20our%20podcast%20created%20to%20reign/Our work is entirely supported by donations from people like you. If you benefit from our work and would like to partner with us, please visit www.cornwallalliance.org/donate. 

Elles sont femmes de Harkis et pendant des décennies ont tissé des tapis d'exception pour le mobilier national. Licières à la manufacture de Lodève, elles sont passé avec dextérité du motif berbère au style Louis XIV ou Empire. Mais qui sont ces femmes restées dans l‘ombre et quelle est leur histoire ? Théa Ollivier a mené l'enquête. En 1964, deux ans après la fin de la guerre d'Algérie et les Accords d'Évian, une soixantaine de familles harkis arrivent à Lodève, dans l'Hérault, au pied du Larzac, après un passage par les camps de Rivesaltes ou de St Maurice l'Ardoise. Les femmes sont recrutées pour tisser des tapis dans un atelier installé dans un ancien baraquement militaire. En 1966, cet atelier devient une annexe de la Manufacture nationale de la Savonnerie et passe sous la responsabilité du Mobilier national. Les tapis produits à Lodève sont destinés aux plus hautes institutions de la République. Pendant des décennies, ces femmes ont tissé des œuvres destinées aux lieux de pouvoir. Pourtant, leur histoire est restée largement invisible. Aujourd'hui, une association locale Mémoires Méditerranée se mobilise pour faire reconnaître leur travail et première victoire, leur parcours vient tout juste d'intégrer la collection permanente du Mémorial du Camp de Rivesaltes. Ce documentaire suit trois anciennes licières — Bakhta, Ledda et Fatma  — aujourd'hui à la retraite. À travers leurs souvenirs et ceux de leurs enfants, il raconte comment la fin de la guerre d'Algérie a façonné des trajectoires de femmes, de familles et de générations. Leur histoire rappelle aussi que la guerre ne s'est pas arrêtée en 1962 : elle s'est prolongée en France, dans les camps, dans le travail, et dans la longue quête de reconnaissance. ► Présentation de l'association Mémoires Méditerranée ► Pour aller plus loin découvrez le webdoc de France 24.   En images

──────────────────────────────────────── [00:05:00] Hegseth Quotes Psalm 144 as God's Blessing for War — Knight: David Prayed Before Every Battle and Never Assumed God Was With Him David used the Urim and Thummim to ask God's will before war. Hegseth has no such instrument and no declaration of war from God or Congress. ──────────────────────────────────────── [00:15:00] Dispensationalism's Core Error: Treating the Shadow as Greater Than the Reality It Points To Knight: Hebrews was written to people returning to the shadow of Judaism rather than the substance in Christ — Hegseth and Huckabee are the Judaizers of Galatians, replacing Christ with a political state. ──────────────────────────────────────── [00:28:00] Nick Kupper: The COVID Shot Was Never Legally Approved — Pfizer Didn't Manufacture an Approved Version Until January 2022 DOD admitted in Kupper's lawsuit that nothing was fully approved until June 2022 — by which time the Air Force had already kicked people out for the unlawfully mandated product. ──────────────────────────────────────── [00:38:00] Kupper's Base Immunologist Admitted He Had More Antibodies Than the Vaccinated — His Religious Accommodation Was Denied Anyway Kupper had natural immunity; his immunologist confirmed he had more antibodies than someone with both shots. Every single religious accommodation filed was denied. ──────────────────────────────────────── [00:50:00] Kupper Was Given Separation Papers Three Weeks Before His 19-Year Mark — One Year Short of a Full Retirement A class-wide court injunction from attorney Aaron Siri covered Kupper the day after his separation papers arrived — but thousands of others had no such protection. ──────────────────────────────────────── [01:02:00] $6 Billion Was Already Appropriated to These Service Members — the Military Used It for Something Else When It Kicked Them Out Kupper: every dollar was authorized in the NDAA but never spent on the personnel allocated — it could be repaid to the 8,000 dismissed without any new appropriation. ──────────────────────────────────────── [01:12:00] A Technical Sergeant With Both Shots Died of Heart Failure in His Early 30s — the Air Force Stopped Updating Its COVID Death Tracker That Day The Air Force had listed 16 COVID deaths noting none were vaccinated — the day this man died with both shots on record, they stopped updating the tracker. ──────────────────────────────────────── [01:22:00] 'Duty to Disobey' Documentary Releases in AMC Theaters June 30 — dutytodisobeyfilm.com Children's Health Defense produced this with service members from multiple branches; Ron Johnson appears alongside those kicked out for refusing the unlawful emergency use mandate. ──────────────────────────────────────── [01:38:00] Dr. Michael Guillén: 95% of the Universe Is Invisible — Modern Cosmology Has Been in Crisis Since Hubble's Discovery in 1929 Dark matter and dark energy are completely unknown. The steady-state model was destroyed by Hubble's discovery that the universe is expanding — the crisis has deepened since. ──────────────────────────────────────── [01:55:00] Guillén: From Atheist to Christian Through Science — the Universe Had to Hit the Jackpot a Million Times at Every Level for Us to Exist The anthropic principle: from the quantum level to the cosmic web, everything was calibrated precisely for life — either infinite accidents or one designer. ──────────────────────────────────────── Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code “KNIGHT” For high quality made in America products go to HomeSteadProducts.shop and use promo code “Knight” for 10% off your purchases Find out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-show Or you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-david-knight-show--2653468/support.

──────────────────────────────────────── [00:05:00] Hegseth Quotes Psalm 144 as God's Blessing for War — Knight: David Prayed Before Every Battle and Never Assumed God Was With Him David used the Urim and Thummim to ask God's will before war. Hegseth has no such instrument and no declaration of war from God or Congress. ──────────────────────────────────────── [00:15:00] Dispensationalism's Core Error: Treating the Shadow as Greater Than the Reality It Points To Knight: Hebrews was written to people returning to the shadow of Judaism rather than the substance in Christ — Hegseth and Huckabee are the Judaizers of Galatians, replacing Christ with a political state. ──────────────────────────────────────── [00:28:00] Nick Kupper: The COVID Shot Was Never Legally Approved — Pfizer Didn't Manufacture an Approved Version Until January 2022 DOD admitted in Kupper's lawsuit that nothing was fully approved until June 2022 — by which time the Air Force had already kicked people out for the unlawfully mandated product. ──────────────────────────────────────── [00:38:00] Kupper's Base Immunologist Admitted He Had More Antibodies Than the Vaccinated — His Religious Accommodation Was Denied Anyway Kupper had natural immunity; his immunologist confirmed he had more antibodies than someone with both shots. Every single religious accommodation filed was denied. ──────────────────────────────────────── [00:50:00] Kupper Was Given Separation Papers Three Weeks Before His 19-Year Mark — One Year Short of a Full Retirement A class-wide court injunction from attorney Aaron Siri covered Kupper the day after his separation papers arrived — but thousands of others had no such protection. ──────────────────────────────────────── [01:02:00] $6 Billion Was Already Appropriated to These Service Members — the Military Used It for Something Else When It Kicked Them Out Kupper: every dollar was authorized in the NDAA but never spent on the personnel allocated — it could be repaid to the 8,000 dismissed without any new appropriation. ──────────────────────────────────────── [01:12:00] A Technical Sergeant With Both Shots Died of Heart Failure in His Early 30s — the Air Force Stopped Updating Its COVID Death Tracker That Day The Air Force had listed 16 COVID deaths noting none were vaccinated — the day this man died with both shots on record, they stopped updating the tracker. ──────────────────────────────────────── [01:22:00] 'Duty to Disobey' Documentary Releases in AMC Theaters June 30 — dutytodisobeyfilm.com Children's Health Defense produced this with service members from multiple branches; Ron Johnson appears alongside those kicked out for refusing the unlawful emergency use mandate. ──────────────────────────────────────── [01:38:00] Dr. Michael Guillén: 95% of the Universe Is Invisible — Modern Cosmology Has Been in Crisis Since Hubble's Discovery in 1929 Dark matter and dark energy are completely unknown. The steady-state model was destroyed by Hubble's discovery that the universe is expanding — the crisis has deepened since. ──────────────────────────────────────── [01:55:00] Guillén: From Atheist to Christian Through Science — the Universe Had to Hit the Jackpot a Million Times at Every Level for Us to Exist The anthropic principle: from the quantum level to the cosmic web, everything was calibrated precisely for life — either infinite accidents or one designer. ──────────────────────────────────────── Money should have intrinsic value AND transactional privacy: Go to https://davidknight.gold/ for great deals on physical gold/silver For 10% off Gerald Celente's prescient Trends Journal, go to https://trendsjournal.com/ and enter the code “KNIGHT” For high quality made in America products go to HomeSteadProducts.shop and use promo code “Knight” for 10% off your purchases Find out more about the show and where you can watch it at TheDavidKnightShow.com If you would like to support the show and our family please consider subscribing monthly here: SubscribeStar https://www.subscribestar.com/the-david-knight-show Or you can send a donation throughMail: David Knight POB 994 Kodak, TN 37764Zelle: @DavidKnightShow@protonmail.comCash App at: $davidknightshowBTC to: bc1qkuec29hkuye4xse9unh7nptvu3y9qmv24vanh7Become a supporter of this podcast: https://www.spreaker.com/podcast/the-real-david-knight-show--5282736/support.

Tyrus guest hosts The Brian Kilmeade Show and speaks with former GOP National Spokeswoman Elizabeth Pipko, Senator Ron Johnson, and the creators of FOX Nation's Rescue Nation. Together, they dive deep into the media's weaponization of race, the Biden administration's weakness on the global stage, and a shocking new congressional report uncovering government data coverups. Don't miss this raw and unfiltered look at the real issues facing America today. [00:00:00] Elizabeth Pipko   [00:18:27] Sen. Ron Johnson   [00:36:50] Reagan Charleston   [00:55:13] Sheldon Yellen & Mike O'Hara   [01:13:37] Link Lauren   [01:32:01] Khamzat ‘Borz' Chimaev Learn more about your ad choices. Visit podcastchoices.com/adchoices

La précarité des artistes, entre autres facteurs, les expose à des climats de travail malsains, entre urgence des répétitions et soumission aux subventions. Pour lutter contre tout type d'abus de pouvoir, les associations Art-Sainement et Safe Spaces Culture s'activent. L'artiste Julia Botelho a pour sa part rédigé son mémoire de fin d'études à la Manufacture sur la mise en scène sans violence. Reportages de Jonas Pool Réalisation: Mathieu Ramsauer Production: Raphaële Bouchet

On today's show, we dive into the cost structure of audio speakers. We start with an article that asks whether 'audiophile' speaker brands are milking you for $20,000. We also read your emails and cover the week's news. News: Important update to your DIRECTV account SVS Auto EQ Room Correction for R|Evolution Subwoofers YouTube TV adds Fox One, Peacock to Primetime Channels store Other: Monoprice Alpha In-Wall Speaker There's never been a better time to grab a new Google TV launcher Are 'Audiophile' Speaker Brands Are Milking You for $20,000 The listeners keep delivering great ideas for show topics. This week Mike LaBorde sent in an article published at headphonesty.com entitled A Former FTC Economist Quit His Job to Prove 'Audiophile' Speaker Brands Are Milking You for $20,000.  The author talks about how a former FTC economist quit his job to design and build affordable high-performance speakers.  He argued that many premium audiophile brands are significantly overpriced because they use similar OEM drivers from the same factories while charging massive markups for branding, cabinets, and dealer margins. We'll break down this article into five points we felt were interesting. The full article is linked and you may want to read it for more details. Many premium audiophile speaker brands rely on the same small group of OEM driver manufacturers (like Sinar Baja/SB Acoustics, SEAS (Scandinavian Electro Acoustic Systems), Scan-Speak, etc.). The same factories and engineering talent supply drivers to both high-end and mainstream brands, even when the final speakers carry vastly different logos and price tags. "Custom" or "proprietary" drivers are often overstated. Most brands customize only the "soft parts" (cone, surround, voice coil) on top of standard off-the-shelf "hard parts" from OEM suppliers, rather than designing and building drivers entirely from scratch. Pricing of speakers — The actual cost of the drivers is a tiny fraction of the retail price. In the Wilson Audio Yvette example, the three drivers cost roughly $530–$580 total, representing only about 2% of the $25,000+ selling price. The vast majority of the cost comes from cabinetry, finish, dealer margins (40-50%), distribution, marketing, and brand prestige, with a typical 5x markup from manufacturing cost to retail. Only a few brands truly manufacture their own drivers in-house. Companies like Focal, KEF, Dynaudio, Paradigm, and Bowers & Wilkins are exceptions. Most premium brands outsource driver production due to the high cost and complexity of vertical integration. High performance doesn't require extreme prices. Former FTC economist Dennis Murphy's Philharmonic Audio proves this by offering well-engineered speakers (like the $850/pair Ceramic Mini using quality SB Acoustics drivers) with minimal overhead, direct sales, and no lavish dealer/showroom costs — challenging the idea that great sound must come with five-figure price tags. The article essentially argues that much of the ultra-premium speaker market is driven more by branding and distribution economics than by revolutionary driver technology. What is the Cost Breakdown of Thousand Dollar Speakers? After going through the previous article we wondered what the actual cost breakdown of Passive bookshelf speakers retailing at $1,000 per pair? ThinkKEF Q series, ELAC Debut Reference, or similar mid to high end consumer hi-fi brands. They balance good performance with accessible pricing.  What follows is our best estimation based on the data we uncovered. If you are in the industry and have better data, please let us know and we will update this analysis. Sources for this analysis include - Audio Science Review, AVS Forum, WhatHifi, headphonesty.com, hubhifi, and a few others.  1. Design & Development (R&D) – Upfront Investment Typical cost: $50,000–$250,000+ for a new model line. Includes acoustic modeling, driver selection/tuning, crossover design, enclosure simulation, multiple prototypes, listening tests, and anechoic chamber measurements. For this price tier, brands often use a mix of off-the-shelf and mildly customized drivers rather than fully bespoke high-end ones.   Amortization: Spread over production volume and for this exercise we used a production run of 5,000–20,000 pairs. This adds roughly $5–$25 per pair at a reasonable scale. 2. Prototyping & Tooling Prototypes: 5–15 iterations at $300–$1,200 each which include custom cabinets, driver samples, hand-assembled crossovers. Tooling: CNC molds/jigs for cabinets, baffle cutting, or vinyl wrap tooling: $8,000–$40,000 upfront. Amortized to $2–$10 per pair. 3. Bill of Materials (BOM) – The Biggest Per-Unit Cost For a typical 2-way passive bookshelf (6.5" woofer + 1" tweeter) at this price point: Drivers - $80–$180 - 6.5" coated paper woofer (~$30–$70 ea.), soft dome or aluminum tweeter (~$15–$50 ea.). Brands like SEAS, SB Acoustics, or custom OEM. Cabinet -  $60-$130, - Braced MDF (18–25mm), vinyl wrap or basic veneer, internal damping, port tube, terminals. Real wood veneer adds premium. Crossover - $30-$80 - 2nd/3rd order with air-core inductors, film capacitors, resistors. Higher quality parts (Mundorf-level) push toward the upper end. Other (grille, wiring, hardware, terminals) - $20-$50 - Magnetic grilles, internal wiring, binding posts. Total BOM per pair: $190–$440 at volume production (typically in China or Vietnam for most brands). Premium touches (better drivers, thicker bracing, nicer finishes) push BOM toward the higher end. 4. Manufacturing, Assembly & Overhead Labor & Assembly: $25–$60 per pair (cabinet gluing/bracing, driver mounting, crossover soldering, final wiring, testing). Quality Control & Testing: Burn-in, frequency sweeps, distortion checks: $10–$25. Factory Overhead/Utilities: $35 - $50. Total Manufacturing per pair: $70 - $135 5. Full Cost Structure to Retail ($1,000/pair) We will assume a large brand that sells 20,000 units and has already invested in tooling and requires minimal new tooling for each new speaker design.  Design and R&D Amortized - $5 Prototype and Tooling  - $2 Bill of Materials - $315 - We split the $190 - $440 down the middle Manufacturing -  $103 - We split the $40 - $135 down the middle Shipping, duties etc to distributor per pair on average - $50 Total to Manufacture $474. The rest of the thousand dollars covers the distribution chain, branding, and profit. And in reality, depending on the efficiency of the factory and ability to leverage design histories from years of experience, the soft costs can be about a third of $110 we came up with, bringing the total cost to about $400. Key Variables Affecting Cost Volume: Higher production = lower per-unit costs. Driver Quality: Exotic materials (beryllium tweeters, carbon fiber) can double driver costs. Cabinet Finish: Vinyl vs. real walnut veneer = big difference. Brand Positioning: Established names (KEF, ELAC) have higher R&D/marketing allocation than direct-to-consumer brands. For comparison DIY builders can replicate similar performance for $300–$600 per pair in parts using higher quality drivers and crossover components and flat-pack or self-built cabinets, eliminating most of the overhead and markups. And after building over 30 sets of speakers I can say without doubt that what you build will sound as good as speakers costing ten times the amount. Plus you can use material that works best for you as well as customizing the look to match your decor. Even my latest set built from stock off the shelf components bought from Part Express for about $200 sound simply amazing!  

Last month, an article in the New Statesman went viral. “Meet the Angry Young Women”, it was titled. “Across Britain a radical new feminism is rising”. What makes someone radically left-wing according to this article? Disliking billionaires, feeling anxious about social injustice, caring about Gaza, and of course – having pink hair and a nose ring. How very radical! The New Statesman article was then seized upon by The Times and The Telegraph in particular, who bemoaned that we should "Forget the Manosphere" and instead focus on "Angry leftie women" who are apparently "the vanguard of the Left's toxic empathy". 6 in 10 women wouldn't date someone who doesn't have the same view as them on Israel-Palestine, they gripe. Yet the articles fail to mention that the data set also found that 5 in 10 men feel the same. Can angry young women who are exercising their democratic right to vote really be compared to the angry young men of the manosphere, who are perpetuators and some even proven perpetrators of sexual violence? What is the media's real aim behind these lazy comparisons? And is the femosphere even real, or did the media manufacture it? Joining us on Media Storm to actually discuss why women are so bloody angry, is therapist and activist Megan Cooper (who was misrepresented and misquoted in the original article) and founder of Cheer Up Luv, Eliza Hatch. This episode is hosted and produced by Mathilda Mallinson (⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@mathildamall⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠) and Helena Wadia (⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@helenawadia⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠)  The music is by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @soundofsamfire⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow us ⁠@mediastormpod Edited by Toka Qassem Learn more about your ad choices. Visit podcastchoices.com/adchoices

Learn a simple way you can generate a state of confidence and trust on game day. Confidence on game day is needed because it gives you the freedom you need to let go of the result and be present. When you are present, you play your best. 

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2064: Nir Eyal explains how variable rewards and user investment transform ordinary products into habit-forming experiences that keep people coming back. By understanding how companies use triggers, anticipation, and personal investment to shape behavior, listeners can better recognize the psychology behind modern technology while learning how these same principles can be used to build healthier and more beneficial routines. Read along with the original article(s) here: https://www.nirandfar.com/how-to-manufacture-desire/ Quotes to ponder: "Variable schedules of reward are one of the most powerful tools that companies use to hook users." "The fact that we have greater access to the web through our various devices also gives companies greater access to us." "Introducing variability multiplies the effect, creating a frenzied hunting state, activating the parts associated with wanting and desire." Episode references: Skinner box: https://en.wikipedia.org/wiki/Operant_conditioning_chamber Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2063: Nir Eyal explores why products like Facebook, Twitter, and Pinterest become so deeply ingrained in our daily routines by breaking down the psychology behind habit-forming technology. He reveals how successful companies manufacture desire through a four-step process that taps into human behavior, emotions, and motivation, offering valuable insight into the mechanics of attention and engagement in the digital age. Read along with the original article(s) here: https://www.nirandfar.com/how-to-manufacture-desire/ Quotes to ponder: "Instead of relying on expensive marketing or worrying about differentiation, habit-forming companies get users to cue themselves to action by attaching their services to the users' daily routines and emotions." "The Hooked Model is a way of describing a user's interactions with a product as they pass through four phases: a trigger to begin using the product, an action to satisfy the trigger, a variable reward for the action, and some type of investment that, ultimately, makes the product more valuable to the user." "Startups manufacture desire by guiding users through a series of experiences designed to create habits." Learn more about your ad choices. Visit megaphone.fm/adchoices

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Virtually every major war begins under false pretenses. German economist Richard Werner explains what the current global conflict is actually about. (00:00) The Effect of Propaganda in Wartime (11:52) The Return of Total War (53:28) Is There Danger of Japan and China Collaborating? (1:07:51) China's One-Child Policy and Anti-Population Growth (1:18:17) The Great Deception Richard A. Werner is an Oxford- and LSE-educated economist, professor of banking and finance, and internationally recognized expert on central banking and monetary policy. He is best known for coining the term “Quantitative Easing” in 1995 and for his bestselling book Princes of the Yen. Over a 30-year career, Werner has advised governments, central banks, pension funds, and major global financial institutions. His research on banking, credit creation, and financial crises has become some of the most widely downloaded academic work in the world, making him a leading voice on economic reform and the global economy. Paid partnerships with: Black Rifle Coffee: Promo code "Tucker" for 30% off at https://www.blackriflecoffee.com StopBox USA: Get firearm security redesigned and save 10% off @StopBoxUSA with code TUCKER at https://stopboxusa.com/TUCKERGood Ranchers: Start your plan today and you'll get FREE meat included with every order PLUS $100 off your first three orders. Use code TUCKER at https://go.goodranchers.com/tucker Learn more about your ad choices. Visit megaphone.fm/adchoices

Can aging be fundamentally slowed or even reversed—not by science fiction, but by harnessing the unassuming power of super-early stem cells?In Part 1, Yuta Lee, Founder and CEO of Accelerated Bio, walked through the biology, ethical sourcing, and manufacturing profile of human trophoblast stem cells. In Part 2, the conversation shifts to the larger ambition: using those cells not just to treat disease, but to slow, stop, or reverse biological aging itself. The evidence starts with a striking finding from the National Institute on Aging, and it builds from there.Topics discussed:The science and ethics of sourcing stem cells from ectopic pregnancies (03:02)Differences in differentiation potential between very early-stage cells and traditional MSCs or iPSCs (05:09)The origins of the research focus, driven by NIH/NIA inquiry and lessons from Stanford parabiosis studies (07:27)Explanation of senescent cells, inflammation, and disease connections (08:51)Potential therapeutic scope, from neurodegeneration to autoimmune diseases, and systemic anti-inflammatory applications (09:26)Vision for aging prevention—possibility of maintaining young biological age through regular secretome therapy (10:21)Challenges and global differences in regulation, access, and clinical adoption (12:05)The realistic limits and potential for reversing versus preventing age-related damage (13:20)The future landscape of cell and gene therapy in medicine (14:20)Why more investment is needed in longevity science and therapeutics (16:25)Practical takeaways for listeners about improving healthspan and longevity today (18:07)Smart insight:Prevention is becoming the new frontier of medicine, shifting from treating disease to preserving long-term biological function. Yuta Lee highlights a future where proactive longevity strategies, from lifestyle choices to emerging biotech, could keep us healthier for longer and push toward “escape velocity” against aging.If you're interested in how we turn living biology into scalable, reliable, off-the-shelf therapies without losing control of the system, explore these episodes:Episodes 105 - 106: From Proteins to Cell Therapy: Why ATMPs Aren't Just Complex Biologics with Oliver KraemerEpisodes 147 - 148: Lab-Grown Blood: How Stem Cells Transform Transfusions with Ari GargirEpisodes 179 - 180: How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay DaviesEpisodes 211 - 212: When the Innovator Becomes the Patient: Manufacturing Reality vs. Patient Urgency with Jesús ZurdoConnect with Yuta Lee:LinkedIn: www.linkedin.com/in/yuta10Accelerated Bio website: www.acceleratedbio.comNext:If you enjoyed this episode, please leave a review on Apple Podcasts or your favorite podcast platform. By doing so, we can empower more scientists like you. Stay tuned for more inspiring biotech insights in our next episode.Support the show

The successful conclusion to the Artemis II mission on April 10, 2026, ushered in a new era of enthusiasm for manned space flight. For NASA, the next steps in this incredible journey will include mankind's establishing permanent habitation on the moon and Mars. But a lot of work has to be done before those dreams can be fully realized. For example, what supporting infrastructure will be needed to underpin these future colonies, and how do we build it in airless, waterless environments? Our guests today include Dr. Nancy Currie-Gregg, former NASA astronaut and current director for the newly minted Texas A&M University Space Institute, and TTI Agency Director Greg Winfree. TTI is teaming with the A&M Space Institute to help Texas and the United States position themselves to advantage in the growing space economy. | Learn More about the Texas A&M Space Institute

Design well. Manufacture to exceed expectations. Take no shortcuts. Audit properly. Audit regularly. Be the customer. Constantly improve. Imagine if you were to run your company with these seven principals? The result could be a premium price that you explain once, and that is defended by exceptional deliverables.Support the show

What if the key to scalable, off-the-shelf cell therapy was hiding in tissue that surgeons discard every day?Yuta Lee, Founder and CEO of Accelerated Bio, has spent two decades building a cell therapy platform on exactly that insight. Human trophoblast stem cells, sourced from ectopic pregnancy tissue that is otherwise discarded, sit at a unique biological intersection: earlier than MSCs, free from the ethical barriers of embryonic stem cells, expandable to 85 population doublings, and naturally equipped with HLA-G immune modulation that opens the door to allogeneic, off-the-shelf therapy at scale.Topics discussedCommon misconceptions and challenges in bioprocess development for biological therapeutics (02:45)The origin story behind Yuta Lee's interest in stem cells, including his father's surgical discovery (04:15)A look at the intellectual property strategy that protected and enabled Yuta Lee's company to develop its platform (07:26)A clear explanation of different stem cell types (embryonic, trophoblast, mesenchymal, adult, and induced pluripotent) and their sources (09:37)Ethical and regulatory issues involved in sourcing stem cells, and how trophoblast cells offer a unique alternative (10:59)Discussion of stem cell differentiation, population doubling, and scalability for manufacturing purposes (17:03)Importance of immune privilege and HLA-G expression in pre-placental cells for off-the-shelf therapies (20:20)Shifts in the industry from autologous to allogeneic therapies, and the role trophoblast cells may play in future treatments (22:00)In Part 2, Yuta Lee goes into the science of biological aging, the senescent cell secretome findings from the National Institute on Aging, and what a prevention-first therapeutic approach to healthspan extension could look like in practice.Smart insight:The scalability ceiling of MSCs is not just a manufacturing inconvenience, it is a strategic constraint. At 25 to 30 population doublings from birth-derived donors, every new donor batch requires revalidation as a distinct biological starting material. Trophoblast stem cells at 85 doublings from a single donor change that equation fundamentally, making true allogeneic scale not just biologically possible but manufacturable.If you're interested in how we turn living biology into scalable, reliable, off-the-shelf therapies without losing control of the system, explore these episodes:Episodes 105 - 106: From Proteins to Cell Therapy: Why ATMPs Aren't Just Complex Biologics with Oliver KraemerEpisodes 147 - 148: Lab-Grown Blood: How Stem Cells Transform Transfusions with Ari GargirEpisodes 179 - 180: How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay DaviesEpisodes 211 - 212: When the Innovator Becomes the Patient: Manufacturing Reality vs. Patient Urgency with Jesús ZurdoConnect with Yuta Lee:LinkedIn: www.linkedin.com/in/yuta10Accelerated Bio website: www.acceleratedbio.comNext:If you enjoyed this episode, please leave a review on Apple Podcasts or your favorite podcast platform. By doing so, we can empower more scientists like you. Stay tuned for more inspiring biotech insights in our next episode.Support the show

Get Shaan's $0-$1M guide: https://clickhubspot.com/rgfr Episode 823: Sam Parr ( https://x.com/theSamParr ) and Shaan Puri ( https://x.com/ShaanVP ) talk about their billy of the week, childhood passions and people making millions on TikTok selling stuff.  — Show Notes:  (0:00) Billy of the week (8:25) Raising kids with an edge (13:37) childhood passions (26:44) Random TikTok People Are Making Millions Selling Hoodies (42:11) the best brands start janky — Check Out Sam's Stuff: • Hampton (joinhampton.com): My community for founders. Average member does $25m/year. Many of the guests are members. Get after it...apply: http://joinhampton.com/mfm — Check Out Shaan's Stuff: • Shaan's weekly email - https://www.shaanpuri.com  • Visit https://www.somewhere.com/mfm to hire worldwide talent like Shaan and get $500 off for being an MFM listener. Hire developers, assistants, marketing pros, sales teams and more for 80% less than US equivalents. • Mercury - Need a bank for your company? Go check out Mercury (mercury.com). Shaan uses it for all of his companies! Mercury is a financial technology company, not an FDIC-insured bank. Banking services provided by Choice Financial Group, Column, N.A., and Evolve Bank & Trust, Members FDIC • I run all my newsletters on Beehiiv and you should too + we're giving away $10k to our favorite newsletter, check it out: beehiiv.com/mfm-challenge My First Million is a HubSpot Original Podcast // Brought to you by HubSpot Media // Production by Arie Desormeaux // Editing by Ezra Bakker Trupiano /

https://teachhoops.com/ In the world of high-level competition, we often talk about players who "play with a chip on their shoulder." It's that invisible weight that drives a player to outwork the "top-tier" recruit, to dive for the loose ball in a 20-point blowout, and to treat every practice like a Game 7. But as coaches, we have to understand that a "chip" is a double-edged sword. When harnessed correctly, it is the ultimate fuel for Resilience and Effort. When left unchecked, it can turn into "Hero Ball," resentment toward teammates, or a lack of emotional control that leads to technical fouls. To build a championship culture, you must teach your players how to use that perceived disrespect as a "Strategic Advantage" rather than an emotional burden. The "chip" usually stems from a specific moment of rejection: being cut from a team, being ranked low in a scouting report, or being told they are "too small" or "too slow." This creates a "Prove Them Wrong" mentality. As we discuss in our TeachHoops member calls, this is the most powerful internal motivator in sports. Unlike "external" rewards (trophies, sneakers, social media clout), the chip is internal and renewable. It's what allowed players like Steph Curry or Draymond Green to transform from "undersized prospects" into Hall of Fame legends. Not every player arrives at your gym with a natural chip on their shoulder. Sometimes, as a coach, you have to be the one to "Manufacture the Disrespect." This doesn't mean being a "jerk"; it means highlighting the reality of the landscape. Show them the preseason rankings where they are picked to finish 5th. Point out the "All-Conference" lists they were left off of. By acting as the "Chief Filter Officer," you help your players notice the "Red Cars" of external doubt, turning that collective energy into a "We Against the World" program identity. The biggest mistake a young player makes is confusing "playing with a chip" with "playing angry." Anger is chaotic; it leads to reaching on defense, forced shots, and losing focus on the scouting report. A "Chip" is calculated. It's the player who is so insulted by an opponent's lack of effort that they decide to physically dominate them within the rules of the system. We want "Quiet Intensity"—the player who doesn't say a word to the trash-talking opponent because they are too busy "out-executing" them. Basketball motivation, playing with a chip, underdog mentality, team culture, high school basketball, youth basketball, basketball IQ, coach development, athletic leadership, "The Villanova Way," mental toughness, player development, championship habits, "Prove Them Wrong" mindset, coach unplugged, teach hoops, basketball success, leadership standards, program building. Show Notes1. The Psychology of the "Underdog"2. Manufacturing the "Chip" (The Chief Filter Officer)3. Playing "With" a Chip vs. Playing "Angry"The "Chip" Audit: Fuel vs. FrictionTraitThe "Fuel" (Championship Level)The "Friction" (Program Killer)Response to Error"Next Play" speed; works harder next rep.Sulking, blaming teammates or refs.Defensive EffortTakes it personally when a man scores.Chases blocks/steals to "look good."LeadershipDemands the standard from everyone.Berates teammates for not being "as tough."Game SpeedSprints the floor to prove a point.Jogs until they get the ball in their hands.SEO Keywords Learn more about your ad choices. Visit podcastchoices.com/adchoices

===La biennale Bâtir Vivant a fermé ses portes le 12 avril dernier ! Elle a ete initiée par l'Institut pour un Design Soutenable et produite par Artistik Bazaar.Elle fut consacrée aux innovations matériaux sans empreinte plastique ni chimie lourde de synthèse.Avec cette grande exposition (1200m2), l'intention est de sensibiliser les industriels, ingénieurs, décideurs et étudiants aux alarmes des scientifiques sur les enjeux de l'empreinte plastique spécifiquement dans les intérieurs.Vous avez surement vu passer l'étude du CNRS de Toulouse (Yakovenko et al., 2025) qui vient d'actualiser l'ampleur de notre exposition. Nous inhalons 100 fois plus de particules qu'estimé, principalement à cause de l'érosion chronique des objets qui nous entourent. Aussi pour accélérer la baisse notre exposition à ces molécules, Bâtir Vivant a mis en lumière les dernières innovations indépendantes de matériaux qui n'en contiennent aucune…une terra incognita aux multiples potentiels et riche d'espoir !L'intégralité de la curation Design soutenable (par Hélène Aguilar) et Artistique (par Marie-Cassandre Bultheel) est disponible en détail sur le podcast BÂTIR VIVANT —Par l'Institut pour un Design SoutenableCopilotépar Hélène Aguilar et Marie-Cassandre BultheelProduit par Artistik BazaarMécènes : Ministère Culture, Roka, Estia, Plendi by Vinci, Fosvia, Norea Environnement, Paris Office Project, La France Continue, Ligne Roset, Manufacture de Tourly, Fondation LAccolade, Fondation Placoplatre, Adra Studio, Xxo, Bignon Lebray, Eiffage Construction, NL Pays-BasPartenaires : Arte, Le Figaro, Mover, SayWho, G-on et G-on LifePartenaires scénographiques : BC Materials, Sammode, Horticulture & Jardins, Atelier Échelle Un, Boutures, Adaozan, Seta Zandi, GaltaneHébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

SPLC and Democrats' “Fake hate” exposed. This is how Democrats use the Southern Poverty Law Center to manufacture extremism for power and profit. Learn more about your ad choices. Visit podcastchoices.com/adchoices

As Watches and Wonders 2026 opens its doors in Geneve, we are honored to be joined by the talented Guido Terreni, CEO Parmigiani Fleurier since 2021. During his tenure, Guido has worked hand in hand with Michel Parmigiani, the famed watchmaker known within the industry as he man with Golden Hands due to his unmatched skill in restoring complex, historically important timepieces. Together, they have honed the unique appeal of the luxury watchmaker, Parmigiani Fleurier, building on 30 years of history and creating timepieces the excel in craftsmanship and epitomize "Private Luxury".  Listen in as Guido and your host, Jeremy Oster, reveal the extraordinary third World Premiere in a series of everyday complication timepieces showcasing the brand's expertise in mechanical excellence with creative application of the "Rattrapante" complication as perfected in the brand's famous GPHG-winning Chrono and PF Split-Seconds Chronograph models. The new PF Chronograph Mysterieux is a work of mechanical genius. Turning an elegant 40mm 3-hand watch into a mono-pusher chronograph with the push of a button is the perfect expression of technical mastery combined with incredible discipline in consistent design which is why Parmigiani Fleurier today is considered one of the watch industry's most highly respected brands  the world over.  Guido shares incredible insights into the legacy of Parmigiani Fleurier as the brand celebrates its 30th Anniversary in style. We discuss the incredible technique used to create the new pieces which feature remarkable hand-hammered dials. Only 30 pieces of each of the 3 versions will be produced by the Manufacture making this collection extremely rare.  As always, the conversation is free-flowing and filled with rare insights as only the CEO of the brand could offer. We greatly thank Guido Terreni and all at Parmigiani for making this episode possible for the listeners of Keeping Time. Thanks as always to co-host and producer Doug Hoyt. Thanks to all of our listeners. Suggestions for future guests? Feedback? Email keepingtime@osterwatches.com.  If you enjoy Keeping Time podcast please do consider rating and reviewing so others can discover the podcast and share with your friends.  Visit the Keeping Time Podccast blog page for corresponding photos  and the complete podcast listing.

Can Texas find a way to consistently manufacture runs? full 762 Tue, 07 Apr 2026 18:00:00 +0000 hDMcEfkqFY0G9bwCkeQoQCL7sgmw88qW mlb,texas rangers,sports The K&C Masterpiece mlb,texas rangers,sports Can Texas find a way to consistently manufacture runs? K&C Masterpiece on 105.3 The Fan 2024 © 2021 Audacy, Inc. Sports False https://player.amperwavepodcasting.com

12pm hour of The K&C Masterpiece! Rangers-Mariners / And can Texas find a way to consistently manufacture runs? NFL Draft Overreaction or Reality. Masterpiece Theatre: What was the last TV show you saw that you absolutely hated?

Something has been building quietly in the UFO space for the past few years. The Overton window around non-human intelligence has shifted. Insider sources are whispering about a contact event in 2026 or 2027. And a very old theory—that a fake alien invasion could be engineered to manufacture consent—is surfacing again in places Kelly can no longer dismiss as fringe. In this Field Notes episode, she doesn't tell you what to believe. Instead, she runs the thought experiment: if someone were preparing the public for something, how would it unfold, and what would it accomplish? The scenario she constructed is fiction. The mechanisms it describes are not. Read the transcript on Substack.

The Iran War is not very popular with Americans – and the Trump Administration seems to think it knows why: the media is being too mean about the President's war of choice. On Saturday, FCC Chairman Brendan Carr reposted a Trump Truth Social screed against The New York Times and Wall Street Journal on Twitter — adding, “The law is clear. Broadcasters must operate in the public interest, and they will lose their licenses if they do not.” Carr has real power in his role as FCC Chairman – power he wants to use on behalf of President Trump. So to talk more about the FCC under Brendan Carr, we spoke with Matt Gertz. He's a senior fellow at the progressive media watchdog, Media Matters.And in headlines, the gloves came off during Oklahoma Republican Senator Markwayne Mullin's confirmation hearing, the government's top intelligence officials testify about worldwide threats before the Senate, and The New York Times publishes a multiyear investigation revealing labor activist Cesar Chavez's sexual abuse of women and girls.Show Notes: Check out Matt's work – www.mediamatters.org/author/matt-gertz Call Congress – 202-224-3121 Subscribe to the What A Day Newsletter – https://tinyurl.com/y4y2e9jy What A Day – YouTube – https://www.youtube.com/@whatadaypodcast Follow us on Instagram – https://www.instagram.com/crookedmedia/ For a transcript of this episode, please visit crooked.com/whataday

What does it look like for something to be made in America? Through the photography of Christopher Payne, we journey across the past, present and future of American manufacturing to answer this question. From centuries-old textile mills to modern assembly lines, Payne's photographs offer a rare, behind-the-scenes view of how everyday objects—from pencils to airplanes to marshmallow Peeps—are made. With the help of Smithsonian curator, Susan Brown, and author, Rachel Slade, we also explore the history behind these factories, and how the story of American manufacturing is the story of our nation itself. Guests: Christopher Payne, Industrial photographerSusan Brown, associate curator, and acting head of textiles at Cooper Hewitt Smithsonian Design Museum; curator of the exhibition Made in AmericaRachel Slade, author of the book Making it in America: The Almost Impossible Quest to Manufacture in the U.S.A. (and How it Got That Way) 

Former Navy Diver Rob Sembiante doesn't just handle pressure, he seeks it out. From the cramped hull of a nuclear submarine to surviving a near-death slide off a glacier in the Italian Dolomites, Rob has mastered the art of "controlled chaos" to reach elite levels of performance.In this episode, Matt and Rob dive into why voluntarily seeking discomfort is the ultimate hack for business and life. Rob shares how his military training helped him "tactically" take on Vegas, survive a 323-mile ultra-marathon, and why he treats every single day like "Day Zero."As the Crew Chief for theRide (Matt's grueling Mexico-to-Canada cycling expedition), Rob explains the systems he uses to eliminate complacency and keep a high-performing team moving when things get "convoluted and distorted.Connect with Rob: https://www.instagram.com/rob.sembiante?igsh=MWp2OW55ZnJxOGppZw==Learn More About theRide: https://gobundance.com/therideConnect With MattYouTube: https://www.youtube.com/@mattkingatxInstagram: https://www.instagram.com/mattking.atxWebsite: http://themattking.com/The Tribe of High-Performing Men: http://gobundance.com/tribe#entrepreneur #navydiver #mentalperformance #mattkingshow #theride #gobundance #discipline

Send a textFollow the hosts on Instagram @alonbenjoseph, @scarlintheshire, @davaucher and @robnudds.Thanks to @skillymusic for the theme tune.

With 3,500 mobile home units under management, Andrew Keel is an expert at “forcing” value and “manufacturing” cash flow even from underperforming assets. He's so dedicated to making each mobile home park investment work that he's even lived on-site (with his family) to ensure value is being added from the second he closes.  Through infill, diligent operations, and crucial fixed-rate debt, Andrew has been able to grow his portfolio at a time when many operators are forced to give up theirs. This wasn't by luck, but by design, and Andrew's advice can help any investor, whether investing in mobile home parks or other assets, add value, increase cash flow, and succeed in secondary and smaller markets.  Andrew says two things can increase your cash flow, and three things can kill a deal quickly. If you get a few of these wrong, your NOI can evaporate, but thankfully, they're not hard to spot. Passive investing in mobile home parks? Andrew tells you exactly what to look for in an operator to ensure they'll be able to pull off what their pro forma plans call for.  Insights from today's episode: Two levers that can increase cash flow (significantly) on your next acquisition  The right way to infill a mobile home park, and whether new homes or used homes are worth it Investing in small secondary markets: The rules of thumb Andrew uses to gauge a market's demand  Three things that can kill a deal before it even starts (add to your due diligence checklist) Building your own in-house property management team and why it doesn't need to be profitable to be worth it   — Connect with Andrew on LinkedIn Invest with Andrew and His Team Keel Team YouTube Channel  Recommended Resources: Accredited Investors, you're invited to Join the Cashflow Investor Club to learn how you can partner with Kevin Bupp on current and upcoming opportunities to create passive cash flow and build wealth. Join the Club! If you're a high-net-worth investor with capital to deploy in the next 12 months and you want to build passive income and wealth with a trusted partner, go to InvestWithKB.com for opportunities to invest in real estate projects alongside Kevin and his team.  Looking for the ultimate guide to passive investing? Grab a copy of my latest book, The Cash Flow Investor at KevinBupp.com.  Tap into a wealth of free information on Commercial Real Estate Investing by listening to past podcast episodes at KevinBupp.com/Podcast.