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Emma McKeon is an Olympic icon, an Australian swimming legend, and now a Swammer. At the Paris 2024 Olympics, McKeon became one of only 2 women in swimming to ever win 14 Olympic medals over her career, joining Katie Ledecky who accomplished the same feat at the same meet. SwimSwam caught up with McKeon after she had enjoyed some well-earned rest, recovery, and travel since Paris. The Aussie shared what her life has looked like since stepping away from swimming but also reflected on the leadup to her final meet. McKeon revealed that just 2-3 weeks out from Paris, she was contemplating not even going due to the severity of pain she was having in her shoulders. However, she was able to manage her injury through the Games and walk away with a gold, silver, and bronze, securing her legacy as one of the greatest Olympians ever.
Ep 69: In this episode of Strength To Build, Chelsey sits down with actress, breast cancer survivor, and recent college grad - Miranda McKeon for an honest conversation about how her approach to health, fitness, and mental resilience helped her navigate breast cancer—diagnosed at just 19 years old.Miranda shares what her relationship with health looked like before her diagnosis, how she adapted her routine during treatment, and how she continues to rebuild both physically and emotionally after surviving cancer.This conversation is a reminder that fitness isn't just about aesthetics—it's a tool for strength, healing, and self-confidence. Miranda's story is vulnerable, powerful, and filled with insight for anyone navigating a health challenge or supporting someone who is.Follow Miranda on Instagram: @mirandamckeonStart your 7 day FREE trial of my new app HERE!Want to work one on one with Chelsey?Set up a one on one consultation call here to see if personalized online training is right for you.Join a semi-private class in LA here.Email info@chelseyrosehealth.com to inquire about one on one in person training.Follow Chelsey on Instagram:@Chelseyrosehealth@StrengthtobuildFollow Chelsey on TikTok Here."Submit a question to the show"
Today we're sitting down with Salve Regina's Coach Andrew McKeon. As the Associate Head Coach and Recruiting Coordinator, Coach McKeon wears a lot of hats at Salve, including the S&C programs. Topics Include:Common traits amongst the best arms year-over-yearHandling strength training without a S&C coachNew topics impacting the recruiting processCoach McKeon joined the Salve Regina baseball staff in July of 2018, taking over as the program's pitching coach and recruiting coordinator. McKeon oversees the development of all pitchers on the staff, assists in working with the hitters and is responsible for developing the year-round strength and conditioning needs of the baseball team.He also assists in all operational tasks of the baseball program such as fundraising and academic support. Since joining the staff, the program has gone 157-58-5 overall and has also earned the ABCA Academic Excellence award in each school year. Ready to take your game to the next level? With our holistic and data-driven approach, experienced coaches, and cutting-edge technology, RPP Baseball takes the guesswork out of player development. Twitter https://twitter.com/RPP_Baseball/ Instagram https://www.instagram.com/RPP_Baseball/ Call us at 201-308-3363 Email us at rpp@RocklandPeakPerformance.com Website ...
On this Special Edition Episode of No Brains No Headache the guys are joined in studio by Mckeon of Birdie Mac to discuss:Life hacks can be ridiculousCondiments and all their gloryMeeting PeopleHumans at their core just want to partyCaps Lock conundrumIs Matt gay? Getting scared too easilyCubs, Phillies and NBA discussionBirdie Mac LatestH9dden Gems Golf seriesThank you for listening!Follow No Brains No Headache on social media and make sure to follow, rate, and review wherever you get your podcasts. Apple Podcasts. Subscribe + rate + review.Spotify. Follow along.iHeartRadio. Or wherever you listen to your favorite shows.New episode every Tuesday!Twitter. https://twitter.com/nbnhpodcastInstagram. https://www.instagram.com/nobrains_noheadache/Facebook. https://www.facebook.com/nbnhpodcastYouTube https://www.youtube.com/channel/UCQbXoHzYhhDigOaNXVYdK3gTik Tok. @NBNHPodcast
Nouvel épisode de Tailgate ELF, l'émission dédiée à l'actualité de l'European League of Football et à l'actualité des Paris Musketeers.Pour ce nouvel épisode, Flav, Waick et Julien reviennent sur tous les mouvements qui ont marqué l'intersaison. Une attaque transformée et une défense qui s'annonce au top feront partie des forces vives pour une saison réussie chez les Paris Musketeers.En cours d'émission, nous recevons John McKeon, CEO des Paris Musketeers qui vient nous parler du partenariat avec les Saints et des expériences de match à vivre à Bondoufle.Bonne écoute à tous et à toutes!Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
KGMI's Dianna Hawryluk talks to WSDOT communications manager RB McKeon about upcoming construction south of Bellingham on I-5, work to clear a rockslide on Chuckanut Driver, people placing stuffed animals in trees, and more.
Dans ce premier épisode de la saison 2025 de Tailgate ELF, le podcast dédié à l'actualité de l'ELF, Flav, Julien et Waick reçoivent le propriétaire des Paris Musketeers, John McKeon!Avec John McKeon tous les changements avant la saison 2025 seront abordés! Comment Jack Del Rio est arrivé à Paris? Comment les dirigeants parisiens ont-ils choisi le nouveau quarterback? Pourquoi avoir changé de stade lors de l'intersaison?On revient ensuite aussi sur les nouveaux joueurs des Musketeers pour la saison 2025 à venir ainsi que sur les objectifs de la franchise parisienne pour cette troisième saison en ELF!Bonne écoute à tous et à toutesHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
When Miranda McKeon was diagnosed with stage 3 breast cancer at 19, everything changed. In this episode, she talks candidly about navigating illness at a young age — from identity shifts and losing her hair to dating while undergoing treatment. Miranda also opens up about launching her business, Fill Your Tank, and how entrepreneurship became part of her healing process. Known for her role in Anne with an E, she's since used her platform to speak openly about vulnerability, growing up in public, and finding agency through uncertainty.Go to https://magicmind.com/unlikemeCode: UNLIKEME20 gets you up to 48% off your first subscription for the next 10 days or 20% off for aone time purchase.
This week's podcast I chat with brothers Stan and Chris McKeon. They have fished together for 65 years on their local water Lough Owel. Together they have both played a big part in making what Owel is today. We chat about all things about this magnificent lough.We start our chat at the angling centre located on the shore of the lake, then onto the hatchery and finish off back at the lakeside.Enjoy!
Learn kind and practical tips to support your ADHD child by downloading the First 3 Chapters of the book for FREE here: https://bit.ly/first_3_chapters —----------------------------------------------------------------------------------------------- In this episode of The ADHD Kids Can Thrive, host Kate Brownfield sits down with Michelle McKeon, an ADHD parent coach, executive functioning coach, and academic coach for children, young adults, and parents. In this episode, they discuss how executive functioning impacts kids in math and writing, making learning more challenging. Michelle, an executive function coach, shares her journey and practical strategies to help parents support their children in building essential skills, reducing frustration, and finding academic success. Michelle McKeon is a certified executive functioning and ADHD coach based in Danville, California. She specializes in helping children, young adults, and parents develop essential learning strategies to navigate ADHD related challenges in school and daily life. With a strong focus on academic coaching, emotional regulation, and executive skills development, Michelle empowers families with actionable techniques to improve learning outcomes. Expect to Learn The connection between executive functioning and academic struggles in math and writing How working memory, organization, and emotional regulation impact learning Practical strategies to support children with ADHD in math and homework How to help kids with writing structure and overcoming overwhelm The role of ChatGPT and AI tools in assisting students with executive function challenges Episode Chapters & Timestamps [01:40] - Introduction to Michelle McKeon [02:53] - Michelle's Personal Journey [05:58] - Why Math is Difficult for ADHD Kids [08:11] - Homework Struggles & Parental Support [11:12] - Helping Older Kids in Math [14:10] - Challenges with Writing & ADHD [16:18] -The Role of AI & ChatGPT in Learning [19:33] - Signs Your Child Needs Extra Support [23:05] - Final Thoughts & Advice for Parents [24:36] - Conclusion Connect with Michelle McKeon: LinkedIn: https://www.linkedin.com/in/michelle-mckeon-m-s-acc-cacp-50898825b/ Website: https://atriumacademics.com/ Follow your Host Kate Brownfield: LinkedIn: https://www.linkedin.com/in/kate-wedlock-brownfield-b0b139 Follow the ADHD Kids Can Thrive Podcast on: Website: http://www.adhdkidscanthrive.com/ YouTube: https://www.youtube.com/@Adhdkidscanthrive Email: adhdkidscanthrive@yahoo.com Subscribe now and share your thoughts in the comments below! #ADHD #ExecutiveFunctioning #ParentingTips #ADHDSupport #MathStruggles #WritingSkills #AcademicCoaching #ADHDEducation
Mark Rittman is joined in this episode by Greg McKeon, Staff Product Manager at dbt Labs to talk about their recent acquisition of SDF Labs, the vision for dbt as the control plane for data collaboration at-scale and the upcoming drag-and-drop Visual Editor that's soon to be part of dbt Cloud.dbt Cloud: The control plane for data collaboration at scaleAbout the Visual EditorCoalesce 2024 and the Launch of dbt's Visual Editing Experiencedbt Labs Acquires SDF Labs to Introduce Robust SQL Comprehension into dbt and Supercharge Developer EfficiencyDrill to Detail Ep.115 ‘Airbnb, DataOps and SQLMesh's Data Engineering Innovation' with Special Guest Toby Mao
We are joined again by Rob McKeon from the Parole Board to discuss his recently published book, 'Parole: The fate of Prisoners in my hands and the high-risk stakes of getting it wrong'. In this episode we also discuss our own book 'A Practical Guide for Parole Practitioners' which has also been recently released.Hosted by The Prison Lawyers, Dean Kingham and John Turner.Guest: Rob McKeon
Swimming Women: McKeon, Winner of 7 Medals at Tokyo Olympics, to Retire
Today our guest is Sea McKeon, the Marine Program Director with the American Bird Conservancy. Sea is a biodiversity scientist, an evolutionary ecologist, a marine biologist, and a natural historian. In this episode, he tells us about the incredible value of seabird poop! Join Catherine Greenleaf, a certified wildlife rehabilitator with 20 years of experience rescuing and rehabilitating injured birds, for twice-monthly discussions about restoring native habitat and helping the birds in your backyard. Access the BIRD HUGGER Newsletter here: www.birdhuggerpodcast.com. Send your questions about birds and native gardening to birdhuggerpodcast@gmail.com. (PG-13) St. Dymphna Press, LLC.
On this Most Notorious episode, we revisit a fan favorite interview, originally released on 12/9/2021. In November of 1971 a man who would come to be known as D.B. Cooper hijacked Northwest Orient Flight 305, ultimately parachuting out of the Boeing 727 in spectacular fashion, along with $200,000 in ransom money, presumably somewhere in Washington State. Who he was and what happened to him after he jumped is one of the most enduring true crime mysteries in American history. My guests are Darren Schaefer, creator and host of "The Cooper Vortex" podcast, and George McKeon, author of "The Mystery of D.B. Cooper: A True Crime Adult Coloring Book". They tell the story of the hijacking, discuss some of the tantalizing clues left behind, and ruminate about possible suspects. Subscribe to The Cooper Vortex on Apple Podcasts here: https://podcasts.apple.com/us/podcast/the-cooper-vortex/id1439712498 and Spotify here: https://open.spotify.com/show/5YRiVfMZX7hfVDSezq1aNo George McKeon's book can be purchased here: https://www.amazon.com/Mystery-D-B-Cooper-Crime-Coloring/dp/1737712709 Learn more about your ad choices. Visit megaphone.fm/adchoices
The fire fades... Content warning: this episode contains mentions of death, rot, decay, existentialism, murder, genocide, cosmic dread, unwanted medical procedures, unwanted bodily transformations Please note - this episode contains mild spoilers for the plots of Elden Ring, Dark Souls III, and Bloodborne This week the episode 100 celebrations continue as Nigel returns to the hotseat four our first themed episode to discuss the themes of rot and decay in FromSoftware games, with Ally and Louise. In this episode we discuss the whether it is cruel to leave a dying world to go on, mirrors between dreams and waking, the possibilities of change, and whether games should have an easy mode. If you liked the episode, please feel free to tell us about it! You can send your comments and suggestions to our podcast Twitter (@HyperfixationsP), or our Instagram (@Hyperfixationspod), and join our Discord server here: https://discord.gg/NQJFFHgpgf --------------------------------------------------------- Our guest Nigel can be found on Twitter @spicynigel And your hosts can be reached individually here: Ally - Twitter: @alleykat_, Instagram: @ally_k_keegan Louise - Twitter: @Tweetingsnail, Instagram: @yeesnail99 --------------------------------------------------------- If you would like to come onto the show to discuss one of your Hyperfixations, please feel free to reach out at any of the aforementioned social media. If you want to come on the show to discuss one of your Hyperfixations, you can also fill in this Google Form and we'll get back to you as soon as we can --------------------------------------------------------- Media mentioned in this episode: RTGame's Elden Ring, Bloodborne, and Dark Souls III playthroughs VaatiVidya's YouTube Channel Dark Souls 3 is Thinking of Ending Things by Jacob Geller --------------------------------------------------------- Thank you so much for listening, you rock! Intro/Outro Song: Strollin Along by David Renda, find it here - https://www.fesliyanstudios.com/royalty-free-music/download/strollin-along/339
Hey guys, we've reached a hundred episodes; take us seriously now. Content warning: this episode contains mentions of nuclear warfare, nuclear annihilation, the genocide in Palestine, the Unabomber, the 9/11 terror attacks This week it's Hyperfixations' 100th episode, and Louise from episode 1 returns for a behind the scenes episode full of exclusives and hot gossip, celebrating the show and how we got here. In this episode we discuss the how the show began, favourite topics and episodes, how to create a safe space for listeners, and the guest that got away. If you liked the episode, please feel free to tell us about it! You can send your comments and suggestions to our podcast Twitter (@HyperfixationsP), or our Instagram (@Hyperfixationspod), and join our Discord server here: https://discord.gg/NQJFFHgpgf Our guest host Louise can be found on Twitter @Tweetingsnail, and on Instagram @yeesnail99 And your guests can be reached individually here: Ally - Twitter: @alleykat_, Instagram: @ally_k_keegan Nigel - Twitter: @spicynigel If you would like to come onto the show to discuss one of your Hyperfixations, please feel free to reach out at any of the aforementioned social media. If you want to come on the show to discuss one of your Hyperfixations, you can also fill in this Google Form and we'll get back to you as soon as we can Media mentioned in this episode: Elisabeth the Musical Tiger King Duck Tales Saw Succession Remember Me Thank you so much for listening, you rock! Intro/Outro Song: Strollin Along by David Renda, find it here - https://www.fesliyanstudios.com/royalty-free-music/download/strollin-along/339
Autoimmune neurology is a rapidly evolving subspecialty that focuses on neurologic disorders with atypical immune responses. In this episode, Aaron Berkowitz, MD, PhD FAAN, speaks with Sean J. Pittock, MD, an author of the article “Overview and Diagnostic Approach in Autoimmune Neurology,” in the Continuum August 2024 Autoimmune Neurology issue. Dr. Berkowitz is a Continuum® Audio interviewer and professor of neurology at the University of California San Francisco, Department of Neurology and a neurohospitalist, general neurologist, and a clinician educator at the San Francisco VA Medical Center and San Francisco General Hospital in San Francisco, California. Dr. Pittock is the director for the Center for Multiple Sclerosis and Autoimmune Neurology at Mayo Clinic in Rochester, Minnesota. Additional Resources Read the article: Overview and Diagnostic Approach in Autoimmune Neurology Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @AaronLBerkowitz Transcript Full transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME. Dr Berkowitz: This is Dr Aaron Berkowitz, and today, I'm interviewing Dr Sean Pittock about his article, “Introduction to Autoimmune Neurology and Diagnostic Approach”, which he wrote with his colleague, Dr Andrew McKeon. This article is a part of the August 2024 Continuum issue on autoimmune neurology. Welcome to the podcast, Dr Pittock. Could you introduce yourself to our audience? Dr Pittock: Well, thank you very much, Dr Berkowitz. So, yeah, I'm a neurologist at the Mayo Clinic. I direct the neuroimmunology laboratory with Dr McKeon and Dr Mills here, and I have also been very much involved in the autoimmune neurology section at the American Academy of Neurology. Dr Berkowitz: So, many of you probably know Dr Pittock - or if you don't know, you've certainly diagnosed diseases that he has described and written about, and so it's a real honor to get to talk to you today and pick your brain a little bit about some of these complex diseases. So, autoimmune neurology is certainly one of the most exciting subspecialties of our field. I feel like when I talk to students and they ask me to make a case for why they should consider neurology as a career, I tell them, “Of course, I have many reasons I love neurology”, but one thing I mention is that, although many other fields of medicine may have made incredible advances as far as treatments, I can't think of too many other fields outside neurology where entirely new diseases have been described since I've been in training and come out of training - and many of those have been in your field of autoimmune neurology. I can think of cases where I've heard you or one of your colleagues on a neurology podcast describing a new antibody, new disease, and a few weeks later, we see that disease and give a patient a diagnosis that had been elusive from other physicians and hospitals. It's a very exciting, gratifying area. It's also daunting, like, every time I go to the AAN and hear one of your colleagues, there's a new disease, and we realize, “Oops! Was I missing that?” or, “Am I going to see this?” And so, hoping to pick your brain a bit today about some of the key concepts and how to keep them in mind so our listeners can recognize, diagnose, and treat these conditions, even if they can't remember every single antibody in your article and all the new ones you and your colleagues will probably discover between now and when this, um, podcast is released. So, before we get into some of the important clinical aspects of these conditions, could you just lay out sort of the broad breaststrokes, the lay of the land of cell-mediated versus antibody-mediated paraneoplastic versus nonparaneoplastic cell surface versus intracellular - how can we sort of organize this area in our minds? Dr Pittock: Yeah. It's complex, and it's really an evolving story. But the importance, really, from the perspective of the reader and the perspective of the clinician is that we're talking about disorders where we can actually do something - we can actually impact patients. And we think about the concept of stopping and restoring in neurology now. We're talking about disorders where we have the potential to stop these inflammatory immune-mediated disorders and, potentially, by stopping early, we may be able to restore function - so, a really important new and evolving field in neurology, because you don't want to miss these conditions. Trying to get your head around the complexity of these entities is difficult, but what we've done in this chapter is, really, to try and lay the groundwork for the following chapters, but provide somewhat of a simplistic approach, but a practical approach that really, I think, can help clinicians. So, the way I think of it, a lot of autoimmune neurology really has stemmed from the discovery of antibodies that cause neurological disease, and the examples of those would be going back to myasthenia gravis (with antibodies to the acetylcholine receptor), going back to Lambert-Eaton syndrome. And then, you know, even if you go back to the older traditional paraneoplastic disorders (the Hu, the Ri, the Yo), at the end of the day, you really have two essential entities, if you want to be very simple. The first is disorders that are caused by an antibody, and the second are disorders where the antibodies you detect are not causing the disorder, but they're telling you that there's predominantly a cellular or T-cell mediated attack of the nervous system. And I think thinking about the diseases in those kind of simple terms helps us when we think about what would be the best treatment to use in these types of cases. Dr Berkowitz: Fantastic. I think that's very helpful. And just to make sure it's clear in the minds of our listeners when we're dividing into these sort of causative antibodies versus antibodies that might be, uh (I don't know if I'm using the word properly), but, sort of epiphenomena (or they're present, but they're not causative) as you said, can you just give some examples of the ones on either side and how making this distinction helps us in practice? Dr Pittock: Yes. So, antibodies that are causative of disease - I think, you know, the one that I've done a lot of work on is in neuromyelitis optica, where you have antibodies that are targeting a water channel that sits on an astrocyte, and so it causes NMOSD, or what we consider an autoimmune astrocytopathy. And we know that when the antibody binds to the target, many things can happen. So, when aquaporin-4 antibodies bind to aquaporin-4, they can do a lot of things. They can cause internalization, they can activate complement that results in the killing of the cell - but there can be other situations. For example, when NMDA-receptor antibodies bind to the NMDA receptor, then a variety of different things can occur different to water channel autoimmunity - where, for example, the receptor (the NMDA receptor) is downregulated off the cell surface, and that results, to some extent, in the neuropsychiatric phenomenon that we see in NMDA-receptor autoimmunity. And, obviously, when you have a situation where the antibodies are causing the disease, removal of those antibodies, or the reduction in the production of those antibodies, is going to help patients. Now, on the other side, we have antibodies that we detect in the blood or in the spinal fluid, and those antibodies are targeting proteins that are inside the cell - so those antibodies we don't consider as being pathogenic. Now, remember, there are sometimes situations where proteins that are inside the cell occasionally can be available for antibodies to bind at certain situations. So, for example, in the synapse, amphiphysin or the septins, may at times become available. And so, sometimes, there are targets or antibodies that are somewhat in between those two simplistic concepts. But when we're talking about antibodies that are targeting proteins on the inside of the cell, remember that antibodies don't just suddenly occur. There's a whole process of presentation of target antigen at the lymph node, and then both a T- and a B-cell response. The B-cell response potentially produces the antibodies but also triggers and stimulates T-cells, and those T-cells then go on to cause the disease. And those T-cells are very problematic, because those classical paraneoplastic and the newer ones we've described (and many have described) - these are associated with quite severe neurological disability, and they're very, very difficult to treat. And if you ask me, “Where is the holy grail of autoimmune neurology therapeutic research?” It's in trying to actually figure out ways of treating the predominantly T-cell mediated paraneoplastic and autoimmune neurological disorders. We're making great headway in terms of the treatments of the antibody-mediated neurological disorders. Dr Berkowitz: That's a helpful overview. So, sticking with this framework, you mentioned as sort of the “causative antibody” category and the antibodies that are predominantly for intracellular antigens, but not believed to be causative - I want to make sure I'm understanding this correctly and we can convey it to our listeners - I believe you said in your paper, then, that the antibodies that are predominantly causative are more likely to be associated with conditions that are very treatable, as compared to the intracellular antibodies that are not thought to be causative, as you just said the disability can be irrecoverable or very hard to treat. And I believe another theme in your paper that you brought out is the antibodies that tend to be causative tend to be cell surface and tend to be less likely to be associated with underlying cancer (although not a perfect rule), and the intracellular antigens more commonly associated with cancer in those cases to look very hard for a cancer before giving up. Are those themes that I understand them from your paper properly, or anything else to add there? Dr Pittock: Yes, I think that that's exactly the message that we were trying to get across, so that's good news that you've picked up on the themes. I think, yeah, in simple terms, remember that when a cytotoxic T-cell identifies the peptide that its T-cell receptor will target, the ultimate outcome is poor, all right? T-cells are like the marines - they don't mess around. Once they find their target, they eliminate that target, and so, it's really difficult to treat those types of diseases if you get them late. And most patients with cytotoxic T-cell mediated paraneoplastic neurological disorders, oftentimes, by the time they get to a center of excellence, the boat has left the dock in many respects - in other words, it's too late. So, you know, I will often see patients, for example, with progressive cerebellar degeneration (say, in the context of Purkinje cell autoantibody type 1 antibodies and a breast cancer), and if those patients are in a wheelchair at the time that I see them, there's very, very little that we can do. So, you really want to try and get that patient into the office, you know, when they're using a cane (or not), and then, potentially, you have the opportunity - using very aggressive immunosuppressive medications - to make a difference. And that is quite different to other scenarios, where, for example, if you have NMDA-receptor encephalitis - as many of the readers will know, this is a condition that is very treatable, and most patients do very well, because the antibodies, they're disrupting function, but they're not killing the neuron, as we see in those more aggressive, paraneoplastic cytotoxic T-cell mediated diseases. Dr Berkowitz: Also, in terms of searching for an underlying cancer, another theme in your paper as I understood (but want to make sure I'm understanding and conveying to our listeners and hear your thoughts), that the cell surface and treatable antibody-mediated syndromes, as you mentioned (NMO, NMDA) tend to be less associated with underlying cancers (although can be), whereas the intracellular antigens, um, a much higher percentage of those patients are going to end up having underlying cancers. Is that correct, or any notable exceptions to be aware of in that framework? Dr Pittock: Yeah, I think the major exception to the rule for the antibodies that are targeting intracellular antigens is the GAD65 antibody story. We generally don't consider the stiff person syndrome, cerebellar ataxia, or other autoimmune neurological disorders associated with very high levels of GAD65 antibodies - those are generally not paraneoplastic. And then there are always exceptions on both sides. You know, one of the benefits of understanding the implications of certain antibodies is trying to understand, you know, what is the likelihood of identifying a malignancy, which antibodies are high-risk antibodies (in other words, high-risk paraneoplastological disorders), and which are low risk in terms of cancer? And, you know, age and the demographic of the individual is often important, because we know, for example, with NMDA-receptor antibodies, the frequency of ovarian teratoma varies with the age of the patient. Dr Berkowitz: Fantastic. And we encourage our listeners to read your articles – certainly, some very helpful tables and figures that help to elucidate some of these broad distinctions Dr Pittock is making - but just to summarize for the antibody-related part of autoimmune neurology, we have one category of cell-surface antibodies and another of intracellular antibodies. Both can cause very severe and varied neurologic presentations, but the cell surface tend to be more treatable, less likely to be associated with the underlying cancer, and the intracellular less treatable, more likely to be associated with the underlying cancer - but, as with everything in neurology and medicine, exceptions on both sides. Is that a fair aerial view of some of the details we've discussed so far, Dr Pittock? Dr Pittock: Yeah, I think so. I mean, I also think that, you know, not only, at least, for the antibody-mediated disorders (you know, as we discussed) we have drugs that will reduce the production of those antibodies, but we're also learning a lot more about the cytokine and chemokine signatures of these disorders. For example, NMO, water-channel antibody-mediated diseases are associated with elevated levels of IL-6. We know, for example, in LGI1 encephalitis and other encephalitides, that IL-6 also is elevated at the time of that encephalitic process. And so, the potential to target IL-6 with, you know, drugs that inhibit IL-6 and the IL-6 receptor, these potentially have, you know, a role to play in the management of these types of patients - whereas in the T-cell mediated disorders, you know, no advance has been made in the treatment of those conditions, I would say, in over 50 years. So, for example, the standard of treatment is steroids and then drugs that impact the bone marrow, and so we really haven't moved forward in that respect. And that, I think, is an area that really needs drive and enthusiastic out-of-the-box thinking so that we can try to get better treatments for those patients. Dr Berkowitz: This has been a helpful overview. I look to dive into some of the scenarios that frontline practitioners will be facing thinking about these diseases. An important point you make in your article is that autoimmune and antibody-mediated neurologic syndromes can affect any level of the neuraxis. Even just our discussion so far, you've talked about anti-NMDA receptor encephalitis, you've talked about myasthenia gravis (that's at the neuromuscular junction), you've talked about paraneoplastic cerebellar degeneration - there can be an “itis” of any of our neurologic structures and that “itis” can be antibody-mediated. So, one of the key messages you give us is, one, that these are sort of in the differential diagnosis for any presenting neurologic syndrome, and, two, sort of one of the key features of the history, really, to keep in mind (since we could be anywhere along the neuraxis) is the subacute presentation when this should really sort of be top of mind in our differential diagnosis - so, many of these patients are going to be mystery cases at the outset. And one striking element you bring out in the paper is that, sometimes, the MRI, CSF, electrophysiology studies may be normal or nonspecifically abnormal, and although it's very helpful when we can send these antibody panels out, in some cases, resources are limited or institutions have certain thresholds before you can send these out (because neurologists love to send them in). Sometimes, they are not necessarily appropriate. So, love to hear your thoughts on when we should be sending these panels. What are some clues? Um we have a subacute neurologic presentation at any level of the neuraxis, and when it's not anti-NMDA receptor encephalitis, that is sort of a clear phenotype in many cases. How you would approach a patient, maybe, where the MRI is either normal or borderline abnormal (or people are squinting at the medial temporal lobe and saying, “Maybe they're a little brighter than normal”), CSF is maybe normal or nonspecifically, um, and the protein is a little high, but no cells? What clues do you use to say, you know, “These are the patients where we should be digging deep into antibody panels and making sure these are sent and not miss this diagnosis?” Dr Pittock: Well, thank you. That's a good question. So, I think, you know, first of all, these are complex cases. So, the patient is sitting in front of you and you're trying to figure out, first of all, Is this a hardware or a software problem? Are we definitively dealing with an encephalitis or an organic neurological entity that's immune-mediated? And, you know, the way I think of it is, for me, you see a patient, it's a twenty-five-piece jigsaw puzzle and you've got two pieces, and you're trying to say, “Well, if I step back and look at those two pieces, do I have any sense of where we're going with this patient?” So, the first thing you need to do is to collect data, both the clinical story that the patient tells you (and I think you make the good point that that subacute onset is really a big clue), but subacute onset, also fluctuating course, sometimes, can be important. The history of the patient - you know, Is the patient somebody who has a known history of autoimmune disease? Because we know that patients that have thyroid autoimmunity are more likely to have diabetes, they're more likely to have gastrointestinal motility or dysmotility, they're more likely to have a variety of different immune-mediated conditions. So, is there a family history or a personal history of autoimmunity? Is the patient at high risk for malignancy? Are there clues that this potentially could be a tumor-initiated immune process affecting the nervous system? The neurological exam also is extremely important because, again, that helps you, first of all, kind of define and get some objectivity around what you're dealing with. So, does the patient have hyperreflexia? Are there signs that there is neurological involvement? And then, really, what I think we need to do is to try and frame the predominant neurological presentation. So, what is the major issue? Because a lot of these patients will have multiple complaints, multiple symptoms, and it's very important to try and identify the major presentation. And that's important, because the neural autoantibody tests are now presentation-defined - in other words, they're built around the neurological presentation, because the old approach of just doing, apparently, a plastic evaluation is gone, because we've got to a stage where we have now so many neural antibodies, you can't test every single neural antibody. So, if you're suspecting that there may be an autoimmune neurological component, then you really need to think about what would be the most appropriate comprehensive evaluation I need to do for this patient. So, for example, if a patient comes in with a subacute-onset encephalopathy, you're probably going to want the autoimmune encephalitis evaluation, and then you have to pick whether it's going to be serum or spinal fluid - and as we outlined in the paper, there are certain antibodies that are better detected in serum versus spinal fluid. So, for example, in adults over the age of 50, LGI1 is much more accurately detected in serum than spinal fluid, and the absolute opposite is true for NMDA-receptor antibody detection. One of the most important components of the neurological evaluation is the spinal fluid, but actually looking at the white cell count - and in fact, sometimes, it's quite interesting to me that I'll often see patients referred with a diagnosis of encephalitis and autoimmune encephalitis, and yet they haven't had a spinal fluid examination. So, the presence of a white cell count, you know, greater than five is hugely helpful - it's like two pieces of that twenty-five-piece jigsaw, because that really tells you that there is something inflammatory going on. And now, in terms of imaging, you're right - some patients will have normal MRI. And if you really do think that there's evidence of - you know, for example, you do an MRI, but you're getting a good sense that there's a temporal lobe seizure occurring, MRI looks normal, the EEG shows some abnormalities in the mesial temporal area - you know, considering additional imaging modalities (like PET scan of the brain), I think, is reasonable. We know that in NMDA-receptor encephalitis cases, 30% of patients will have normal MRI but they'll often have abnormalities on the PET scans. So, I think, what we do is we try to gather data and gather information that allows us to add in pieces of that jigsaw so that, eventually, after we've done this evaluation, we can see now we have ten pieces. If we step back, we say, “Yes, now we know what this condition is”, and then we essentially plan out the therapeutic approach dependent on what we've found. In terms of identification of underlying malignancy, you know, different people have different approaches. Our approach generally has been to try to get a PET-CT scan of the body as our first go-to test, because, actually, we found that CT chest abdomen and pelvis really actually delivers the same amount of radiation - and from a cost perspective, it's about the same - and we have found that PET-CTs really do provide a higher sensitivity for cancer detection. Dr Berkowitz: Perfect. A lot of very helpful clinical pearls there. So, in closing, Dr Pittock, I've learned a lot from you today. I'm sure our listeners will as well. What does the future hold in this field? What's coming down the pipeline? What are we going to be learning from you and your colleagues that are going to help us take care of patients with these diseases going forward? Dr Pittock: Well, thank you, Dr Berkowitz, for that question. I think the future is very bright and very exciting, and, hopefully, some of the more junior members will be enthused by this Continuum series, and, hopefully, we'll go into this area. So, let's talk about the future. The future, I think, is going to be of great interest. Firstly, there's going to be continued discovery of novel biomarkers, and the reasons for that is because of the technical and technological advances we've seen. So, for example, there have been many, many antibodies discovered by us and others that have been discovered on the basis of, for example, phage technology. In fact, the Kelch 11 biomarker discovery in collaboration with UCSF and our group was done on the basis of Joe DeRisi and Michael Wilson's phage approach. And we're actually using that now at Mayo Clinic, and we've discovered about three or four new antibodies just in the last couple of years using this technology (and that here is led by John Mills and Div Dubey). And then, we're also going to see, I think, the evolution of protoarrays much more in biomarker discovery, so, we'll have more antibodies, and again, I think, generally, those antibodies will fall into the two categories we kind of described - so, you know, in terms of the approach to those conditions, maybe not so much change. I do think, though, that the introduction and the utility of comprehensive cytokine and chemokine analysis in the future will assist us in making diagnoses of seronegative encephalitis, but also potentially will direct therapy. So, for example, cytokine A is elevated - maybe that would be a potential target for therapy that's available for these patients with rare and potentially very disabling disorders. Then, when we look at the cytotoxic T-cell mediated disorders, I think the major areas of advance are going to be in better understanding the immunophenotype of cytotoxic T-cell mediated diseases, and then the potential development of tolerization strategies using the specific targets, those specific epitope targets that are involved in paraneoplastic and nonparaneoplastic diseases, and seeing if we can vaccinate patients, but move that immune response into more of a tolerogenic immune response rather than a cytotoxic killing response. And then I think, lastly, we're going to see a dramatic revolution in CAR-T therapeutic approaches to these types of disorders moving forward - and not just, you know, CAR-T therapies that are targeting, you know, CD19 or CD20, but CAR-Ts that are actually personalized and developed so that they can target the specific B- and T-cells in an individual patient and actually do a very fine removal of that autoimmune pathologic process that I think would have significant benefit for patients not only in stopping progression, but also in significantly reducing the potential of side effects - so, a much more targeted approach. So, that's where I think the next ten years is going to be. I think it's very exciting. It's going to require the collaboration of neurologists with, you know, immunologists, hematologists, you know, across the board. So, a very exciting future, I think, for this field. Dr Berkowitz: Exciting, indeed. And we have learned so much from you and your colleagues at the Mayo Clinic about these conditions, and I definitely encourage our listeners to read your article on this phenomenal issue that really gives us a modern, up-to-date overview of this field and what's coming down the pipeline. So, a real honor to get to speak with you, pick your brain about some of the clinical elements, pitfalls and challenges, and also hear about some of the exciting signs. Thank you so much, Dr Pittock, for joining me today on Continuum Audio. Dr Pittock: Thank you very much. Dr Berkowitz: Again, today, I've been interviewing Dr Sean Pittock, whose article with Dr Andrew McKeon on an introduction to autoimmune neurology and diagnostic approach appears in the most recent issue of Continuum on autoimmune neurology. Be sure to check out Continuum Audio episodes from this and other issues. And thank you so much to our listeners for joining us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at Continpub.com/audioCME. Thank you for listening to Continuum Audio.
Everyone has been in a little bit of debt, right? Well trying going from owing $0 to $1.5 million in seconds. Today Britt is joined by Founder of Proud Poppy, Tara McKeon. Find out what forced Tara to take out such an enormous loan and the waves she is making when it comes to inclusive sizing. LINKSFollow Britt on: Instagram @brittney_saunders TikTok @brittney_saunders Check out FAYT The Label HERE. Follow Tara on: Instagram @proudpoppyclothing TikTok @proudpoppyclothing Check out Proud Poppy HERE. CREDITSHost: Brittney Saunders. Senior Producer: Xander CrossManaging Producer: Elle Beattie Find more great podcasts like this at novapodcasts.com.au and follow Nova Podcast's Instagram @novapodcastsofficial Nova Entertainment acknowledges the traditional custodians of the land on which we recorded this podcast, the Gadigal People of the Eora Nation. We pay our respect to Elders past and present. See omnystudio.com/listener for privacy information.
Achtsamkeit fördert unsere mentale – und auch unsere körperliche Gesundheit, sagen Diane Hielscher und Main Huong Nguyen. Wie das funktioniert? In dieser Folge Achtsam sprechen sie über die Zusammenhänge.**********An dieser Stelle findet ihr die Übung:00:44:00 - Achtsamkeitsübung mit Main Huong Nguyen**********Quellen aus der Folge:Farb, N. A., Segal, Z. V., Mayberg, H., Bean, J., McKeon, D., Fatima, Z., & Anderson, A. K. (2007). Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference. Social cognitive and affective neuroscience, 2(4), 313-322. Lindahl, J. R., Fisher, N. E., Cooper, D. J., Rosen, R. K., & Britton, W. B. (2017). The varieties of contemplative experience: A mixed-methods study of meditation-related challenges in Western Buddhists. PloS one, 12(5), e0176239. Moffitt, R., Brinkworth, G., Noakes, M., & Mohr, P. (2012). A comparison of cognitive restructuring and cognitive defusion as strategies for resisting a craved food. Psychology & health, 27(sup2), 74-90. Heidenreich, T., & Michalak, J. (2007). Achtsamkeit und Akzeptanz: Opium für das Volk?. PiD-Psychotherapie im Dialog, 8(02), 194-195. **********Dianes und Main Huongs Empfehlungen:Harrer, M. E. & Weiss, H. (2015). Wirkfaktoren der Achtsamkeit: wie sie die Psychotherapie verändern und bereichern. Schattauer Verlag. **********Mehr zum Thema bei Deutschlandfunk Nova:Inneres Kind: Wie wir loslassen und nach vorne schauenBoreout: Achtsam mit Langeweile umgehenInterbeing: Achtsam mit der Welt in Beziehung leben**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.**********Ihr habt Anregungen, Ideen, Themenwünsche? Dann schreibt uns gern unter achtsam@deutschlandfunknova.de
Affiliate Partnership Links:DORMIFY - DORM DECORClick on the Dormify Link and use our exclusive coupon code for 15% off most products: COLLEGETALK15 PREP EXPERT - TEST PREP/TUTORING: Save 30% on Prep Expert with Coupon Code: COLLEGETALKPREP SPORTSWEAR - COLLEGE CLOTHING & APPAREL Full disclosure: if you make a purchase through the affiliate links we've provided, we'll receive a small commission. But rest assured, we only promote products and services that we truly believe in and think will benefit our listeners.—------------------Alphabetical List of All Episodes with LinksClick Here To Join The Podcast Email List High Point University - Admissions High Point University Oars Program
As salon professionals, we have a unique ability to create a safe space for our clients, and lend a friendly ear. For someone in a domestic violence situation, the salon may be the one of the few or even the only place they can go without their abuser. So how do we identify the signs of domestic violence, and offer the right kind of support for clients and team members who may be in danger? Our guest Liz McKeon is a salon business expert, author of the best-selling book, '30 Days to Beauty Business Success', and and UK & Irish Ambassador for Shear Haven Anti Domestic Violence Industry Training. If you feel unsafe at home, find a hotline for your country or location here. This episode does not contain descriptions of violent acts. Follow Summit Salon Business Center on Instagram @SummitSalon, and on TikTok at SummitSalon. Find host Blake Reed Evans on Instagram @BlakeReedEvans and on TikTok at blakereedevans. His DM's are always open! You can email Blake at bevans@summitsalon.com. Visit us at SummitSalon.com to connect with others in the industry. Join our online community for certified Summit salons, spas, barber shops and beauty schools.Sign up for our newsletter, Your Weekly Game Plan to stay on top of our events and trainings.
Guest Steve McKeon, cyber security expert, joins to discuss data collection from TikTok, social media, the government, and more. Discussion of scammers from China and Russia, collecting data from Americans, and threats with new technology. Discussion of how we protect ourselves from developing of AI. Hunter Biden verdict in. Is it because of the actual crimes, or is Hunter Biden the fall guy to make the judicial system look "unbias" after the Trump case? Discussion of trying to not make Trump look like a martyr. Democrats look to ignore policy issues during campaign, and go back to Trump 2020 election denial.
Episode SummaryWelcome to our family time! Erin and Rachel discuss Brother Bear (2003), another entry in the canon of Disney's flop era. Despite disappointingly little effort on the part of the filmmakers to ensure cultural authenticity, Brother Bear manages to tell a sweet story with surprisingly little offensive content. Episode BibliographyAlaska Travel Industry Association. (2024). Yup'ik and Cup'ik Culture in Alaska. Travel Alaska. https://www.travelalaska.com/Things-To-Do/Alaska-Native-Culture/Cultures/YupikBarton, K. (2020, October 5). How Inuit honour the tradition of naming, and spirits who have passed on. CBC News. https://www.cbc.ca/news/canada/north/inuit-names-tradition-culture-history-1.5748892Billboard Staff. (2003, October 8). Diverse Acts Interpret Collins For 'Brother Bear'. Billboard. https://www.billboard.com/music/music-news/diverse-acts-interpret-collins-for-brother-bear-68741/Billboard Staff. (2003, October 21). Collins, Turner Lead Disney Premiere. Billboard. https://www.billboard.com/music/music-news/collins-turner-lead-disney-premiere-68553/Billington, L. (2003, November 1). 'Brother Bear' mixes nature, Native culture. Anchorage Daily News. https://web.archive.org/web/20031103012857/http://www.adn.com/life/story/4298933p-4309027c.htmlBlaise, A., & Walker, R. (Directors). (2003). Brother Bear [Film]. Walt Disney Pictures. d'Anglure, B. S. (2005). The ‘third gender' of the Inuit. Diogenes, 52(4), 134-144. DOI: 10.1177/0392192105059478Cassady, J. (2008). "Strange Things Happen to Non-Christian People": Human-Animal Transformation among the Iñupiat of Arctic Alaska. American Indian Culture and Research Journal, 32(1). http://doi.org/10.17953Cohn, A. (2003, October 27). Phil Collins Bearly Sings. TV Guide. https://www.tvguide.com/news/phil-collins-bearly-37211/DisneyLivin. (2022, April 29). The Making of Brother Bear. YouTube. https://www.youtube.com/watch?v=U9UOlqZHrXgEbert, R. (2003, October 31). Brother Bear movie review & film summary (2003). Roger Ebert. https://www.rogerebert.com/reviews/brother-bear-2003Eller, C., & Verrier, R. (2002, March 19). Disney Confirms Animation Cuts. Los Angeles Times. https://www.latimes.com/archives/la-xpm-2002-mar-19-fi-disney19-story.htmlHill, J. (2012, September 4). Why For was Michael Clarke Duncan's Grizz character cut out of Disney's "Brother Bear"? Jim Hill Media. https://jimhillmedia.com/why-for-was-michael-clarke-duncans-grizz-character-cut-out-of-disneys-brother-bear/Houston, J. (2006, February 7). Inuit Traditional Stories. The Canadian Encyclopedia. https://www.thecanadianencyclopedia.ca/en/article/inuit-myth-and-legendIndigenous Languages of Alaska: Iñupiaq. (2021, November 1). National Park Service. https://www.nps.gov/articles/000/indigenous-languages-of-alaska-inupiaq.htmInuit languages. (n.d.). Wikipedia. https://en.wikipedia.org/wiki/Inuit_languagesJessen, T. (2003, October 24). Fraternal Obligation: Disney Revisits the Animal Picture with 'Brother Bear'. Animation World Network. https://www.awn.com/animationworld/fraternal-obligation-disney-revisits-animal-picture-brother-bearKjficarra. (2020, January 27). Brother Bear: Yet another example of the transformation trope. From Tonto to Thomas Builds-the-Fire: Native American Representation. https://nativeamericanmediarepresentation.wordpress.com/2020/01/27/brother-bear-yet-another-example-of-the-transformation-trope/Laugrand, F., & Oosten, J. (2014). Hunters, Predators and Prey: Inuit Perceptions of Animals. Berghahn Books.Languages - Iñupiaq | Alaska Native Language Center. (n.d.). University of Alaska Fairbanks. https://www.uaf.edu/anlc/languages-move/inupiaq.phpLeigh, D. (2009). Colonialism, gender and the family in North America: For a gendered analysis of Indigenous struggles. Studies in Ethnicity & Nationalism, 9(1), 70-88. DOI: 10.1111/j.1754-9469.2009.01029.xLuchini, C. (2023, December 15). Human-animal relationships of the Inuit shamanic perspectives on interdependence in the arctic. Medium. https://medium.com/@cristiano.luchini/human-animal-relationships-of-the-inuit-shamanic-perspectives-on-interdependence-in-the-arctic-8852c20781cdMattos, A. M. (2015). Third space: Narratives and the clash of identities in Disney's Brother Bear. Journal of Intercultural Communication, 39, 1-11. McCarthy, T. (2003, October 19). Brother Bear. Variety. https://variety.com/2003/film/awards/brother-bear-1200538552/McKeon, M. (2018, June 24). A Walt Disney Production: "Brother Bear". Medium. https://filmknife.medium.com/a-walt-disney-production-brother-bear-6d6f01c8f3dMoore, R. (2003, October 23). Great Expectations. Orlando Sentinel. https://web.archive.org/web/20150707174308/http://articles.orlandosentinel.com/2003-10-23/news/0310220615_1_feature-animation-brother-bear-disney-animationNess, M. (2016, November 3). The End of an Animated Era: Disney's Brother Bear. Reactor. https://reactormag.com/brother-bear/Oosten, J., Laugrand, F, & Remie, C. (2006). Perceptions of decline: Inuit shamanism in the Canadian arctic. Ethnohistory, 53(3), 445-477. DOI: 10.1215/00141801-2006-001Production Notes - Brother Bear. (2010). Cinema Review. https://web.archive.org/web/20101121085935/http://cinemareview.com/production.asp?prodid=2249Puig, C. (2003, October 23). 'Brother Bear': Warm, fuzzy fun. USA Today. https://usatoday30.usatoday.com/life/movies/reviews/2003-10-23-brother-bear-review_x.htmSerena, K. (2023, March 26). Timothy Treadwell: The 'Grizzly Man' Eaten Alive By Bears. All That's Interesting. https://allthatsinteresting.com/timothy-treadwellSoundlessFOB. (2020, February 6). Do you find the movie Brother Bear offensive? : r/NativeAmerican. Reddit. https://www.reddit.com/r/NativeAmerican/comments/ezp14f/do_you_find_the_movie_brother_bear_offensive/Themes in Inuit Art: Transformation. (n.d.). Feheley Fine Arts. https://feheleyfinearts.com/themes-in-inuit-art-transformation/Turan, K. (2003, October 25). Old school 'Brother Bear'. Los Angeles Times. https://www.latimes.com/archives/la-xpm-2003-oct-25-et-turan25-story.htmlWells, P. (2008). The animated bestiary: Animals, cartoons, and culture. Rutgers University Press. We Speak Inuktut. (n.d.). Government of Nunavut. https://www.gov.nu.ca/en/culture-language-heritage-and-art/we-speak-inuktutWhitley, D. (2012). The idea of nature in Disney animation: From Snow White to WALL-E. Taylor & Francis Group. Williamson, K. J. (2024, March 5). Inuit. Britannica. https://www.britannica.com/topic/Inuit-people
This is a really fun talk with Shauna. We talk about: Going from academia to techDjangoOpen source project governance and Governing OpenWomens Soccer and the NWSLShauna's technical consulting business is Galaxy Rise Consulting The Complete pytest CourseLevel up your testing skills and save time during coding and maintenance.Check out courses.pythontest.com ★ Support this podcast on Patreon ★
fWotD Episode 2559: The Structure of Literature Welcome to featured Wiki of the Day where we read the summary of the featured Wikipedia article every day.The featured article for Tuesday, 7 May 2024 is The Structure of Literature.The Structure of Literature is a 1954 book of literary criticism by Paul Goodman, the published version of his doctoral dissertation in the humanities. The book proposes a mode of formal literary analysis that Goodman calls "inductive formal analysis": Goodman defines a formal structure within an isolated literary work, finds how parts of the work interact with each other to form a whole, and uses those definitions to study other works. Goodman analyzes multiple literary works as examples with close reading and genre discussion.The main points of Goodman's dissertation were made in a 1934 article on aesthetics by the author, who studied with the philosopher Richard McKeon and other neo-Aristotelians at the University of Chicago. Goodman finished his dissertation in 1940, but it was only published in 1954 by the University of Chicago Press at McKeon's behest. Reviews aggregated in Book Review Digest were mixed. Critics described the book as falling short of its aims, with engaging psychological insight and incisive asides mired in glaring style issues and jargon that made passages impenetrable or obscured his argument. Though Goodman contributed to the development of what became known as the University of Chicago's Chicago School of Aristotelian formal literary criticism, he neither received wide academic recognition for his dissertation nor was his method accepted by his field.This recording reflects the Wikipedia text as of 00:30 UTC on Tuesday, 7 May 2024.For the full current version of the article, see The Structure of Literature on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Mastodon at @wikioftheday@masto.ai.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm Geraint Standard.
Greg McKeon is a performer in the adult entertainment industry - creating content that fuels our fantasies. We talk go-go dancing in West Hollywood, relocating to Oregon, embracing his Daddy identity, the war on porn, and his disastrous audition for a role on Teen Wolf. Host: Gareth Johnson Twitter: @gtvlondon
I am so excited to chat with Scott McKeon - not only is he a killer guitarists that has a new album, "New Morning", dropping (that you all will love); but he has a ridiculously amazing pedal line as well! The first time I heard him play, I immediately wanted to be in his band. Grab a comfy chair and kick back with us on this Saturday morning edition of At Home with Mark! Hosted on Acast. See acast.com/privacy for more information.
This weekend's 1 in 36 guest is Sarah McKeon. Sarah is the General Manager of New Jersey Airports for The Port Authority of New York & New Jersey. Most recently, Anderson Center Consulting and Training collaborated with Newark Liberty International Airport on a new sensory room located in Terminal A. The 1,000 square foot sensory lounge for people with intellectual and developmental disabilities provides a calming oasis from the noise and visual stimulation of the airport. Tune in to learn more!
Download my FREE 'Dick Magnet Subliminal Affirmations' at https://georgelizos.com/dickmagnet In the second part of my chat with porn star Greg McKeon, we embark on a candid exploration of OnlyFans secrets, gay cruises, and the intricacies of surprise anal. Join us as we navigate through the complexities of modern-day sexual experiences, emphasizing the importance of consent, communication, and shedding shame around sex. Greg sheds light on the nuances of navigating overly aggressive Dom Tops, the prevalence of OnlyFan bots, and the empowering journey of reclaiming sex as a sacred act, only engaging when genuine desire arises. Our conversation delves into the resurgence of twinks and the vibrant world of gay cruises and cruising apps, while also exploring the taboo realm of glory holes and underground sex parties. Through our dialogue, we aim to challenge slut-shaming attitudes and foster a culture of open-mindedness, acceptance, and respect for all expressions of sexuality. About Greg McKeon Greg McKeon (aka Bishop Manwaring, Grgisthewerd, Joe Manwaring) is a top who is best known for his performances with Bareback Network and Missionary Boyz. In 2020, he was a GayVN Best Fetish Scene nominee for "President Lewis: The Sacrament" (Missionary Boyz) and a StraightUpGayPorn nominee for Best Newcomer and Favorite Butt. His performance as a down-on-his-luck guy finding sexual comfort with his step-nephew in "Failed Inspection" from Disruptive Films is also one of the highlights of his career. OnlyFans: https://onlyfans.com/grgisthewerd Website: https://grgisthewerd.com/ Twitter (X): https://twitter.com/grgisthewerd Instagram: https://www.instagram.com/grgisthewerd About Me I'm George Lizos, spiritual teacher, psychic healer, and #1 bestselling author. Growing up in a small Christian community, I was judged and rejected for being gay and different. After a futile two-year attempt to change who I was born to be, I called myself a human abomination and almost took my own life. Fortunately, in my darkest moment, I saw the light and ventured on a healing journey of love, forgiveness, and spiritual awakening. Yet, my gay dating life since hasn't always been all roses and rainbows, and my past dramas and traumas have definitely kept things spicy. Fast forward past many awkward dates and disappointing sex, I Created Can't Host to challenge toxic gay stereotypes, explore the complex dynamics of gay sex and relationships, and create opportunities for healing and growth. https://georgelizos.com/ Connect With Me Instagram: https://instagram.com/georgelizos/ Website: https://georgelizos.com/ TikTok: https://www.tiktok.com/@iamgeorgelizos Facebook Group: http://www.yourspiritualtoolkit.com/ My Books Be The Guru: https://l.linklyhq.com/l/1TtCj Lightworkers Gotta Work: https://l.linklyhq.com/l/1TmKf Protect Your Light: https://l.linklyhq.com/l/1TmJd Secrets of Greek Mysticism: https://l.linklyhq.com/l/1uPvr
Ky McKeon from Three Man Weave Podcast joined the show to recap the latest storylines in College Basketball and why he trusts Tennessee in the NCAA Tournament. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices
The hosts of No Brains No Headache Podcast are joined by McKeon of Birdie Mac Golf. We weave in and out of golf related discussion and hear about Jordan's venture of going speed dating. Matt has a new faith in his favorite football team and is riddled with anxiety. We review a famous YouTube channel and get one of the best Farmer Fran impersonations. Thank you for listening! Available on: Apple. Subscribe + rate + review. Spotify. Follow along. Anchor. Our creation platform. iHeartRadio. Or wherever you listen to your favorite podcasts. New episode every Tuesday! Twitter. https://twitter.com/nbnhpodcast Instagram. https://www.instagram.com/nbnhpodcast/ Facebook. https://www.facebook.com/nbnhpodcast YouTube https://www.youtube.com/channel/UCQbXoHzYhhDigOaNXVYdK3g Tik Tok. @NBNHPodcast
Download my FREE 'Dick Magnet Subliminal Affirmations' at https://georgelizos.com/dickmagnet Explore the hidden facets of the gay porn industry in this revealing episode with porn star Greg McKeon. From unraveling industry secrets like fake cumshots and penile injections to delving into the financial side, Greg shares insights on how much money porn actors make and whether they have a say in choosing their scene partners. Gain a behind-the-scenes perspective on the intricacies of filming, including the time it takes and the challenges of working with fellow actors. Join us for a candid discussion as Greg peels back the curtain, offering a rare glimpse into the lesser-known aspects of the adult entertainment world. About Greg McKeon Greg McKeon (aka Bishop Manwaring, Grgisthewerd, Joe Manwaring) is a top who is best known for his performances with Bareback Network and Missionary Boyz. In 2020, he was a GayVN Best Fetish Scene nominee for "President Lewis: The Sacrament" (Missionary Boyz) and a StraightUpGayPorn nominee for Best Newcomer and Favorite Butt. His performance as a down-on-his-luck guy finding sexual comfort with his step-nephew in "Failed Inspection" from Disruptive Films is also one of the highlights of his career. OnlyFans: https://onlyfans.com/grgisthewerd Website: https://grgisthewerd.com/ Twitter (X): https://twitter.com/grgisthewerd Instagram: https://www.instagram.com/grgisthewerd About Me I'm George Lizos, spiritual teacher, psychic healer, and #1 bestselling author. Growing up in a small Christian community, I was judged and rejected for being gay and different. After a futile two-year attempt to change who I was born to be, I called myself a human abomination and almost took my own life. Fortunately, in my darkest moment, I saw the light and ventured on a healing journey of love, forgiveness, and spiritual awakening. Yet, my gay dating life since hasn't always been all roses and rainbows, and my past dramas and traumas have definitely kept things spicy. Fast forward past many awkward dates and disappointing sex, I Created Can't Host to challenge toxic gay stereotypes, explore the complex dynamics of gay sex and relationships, and create opportunities for healing and growth. https://georgelizos.com/ Connect With Me Instagram: https://instagram.com/georgelizos/ Website: https://georgelizos.com/ TikTok: https://www.tiktok.com/@iamgeorgelizos Facebook Group: http://www.yourspiritualtoolkit.com/ My Books Be The Guru: https://l.linklyhq.com/l/1TtCj Lightworkers Gotta Work: https://l.linklyhq.com/l/1TmKf Protect Your Light: https://l.linklyhq.com/l/1TmJd Secrets of Greek Mysticism: https://l.linklyhq.com/l/1uPvr
The Mark Titus Show Episode 91 | FULL EPISODE - Ky McKeon from Three Man Weave Subscribe to Mostly Sports with Mark Titus and Brandon Walker on Youtube: https://www.youtube.com/@MostlySportsTitusandWalker?sub_confirmation=1 Subscribe to The Mark Titus Show: https://www.youtube.com/@marktitusshow?sub_confirmation=1 Ky McKeon returns to the show today to talk through the first half of the college basketball season, and start to figure out who the real contenders are going to be come March. On the back half of the episode, Mark and TJ talk Kentucky, Caitlin Clark, court storming, and more. Ky McKeon is decent high school turned pretty decent recreational basketball player, Ky's feathery touch from 15-18 feet is the stuff of legend. He is on the Three Man Weave podcast and he works as an Auditor for an accounting firm in his spare time. Ky attended a Big-12 turned SEC school. Follow Ky on Twitter: https://twitter.com/Ky_3MW Show note: We'll be back with a new episode Friday! Follow the show on all socials: Twitter: https://twitter.com/MarkTitusShow Instagram: https://www.instagram.com/marktitusshow/ Facebook: https://www.facebook.com/MarkTitusShow Tiktok: https://www.tiktok.com/@marktituspod?lang=en Listen on Podcast platforms: Spotify: https://open.spotify.com/show/2TPzE6Oo17yQ0IbLmo5AvY Apple Podcasts: https://podcasts.apple.com/us/podcast/the-mark-titus-show/id1673616227 Follow Mark Titus: Twitter: https://twitter.com/clubtrillion Instagram: https://www.instagram.com/marktheshark34/ Timestamps 0:00 - show starts 2:58 - Interview starts 3:35- Tony Stubblefield fired 7:13 - dayton 9:20 - virginia 16:17- houston 26:50 - dalton knecht 32:10- michigan state 44:44 - bronny james 50:36 - zach edey 1:08:35 - interview ends 1:08:36 - shoutouts start 1:23:06 - show ends If for some reason you see this, subscribe to mostly sports for a hi five. IYKYK.
Marion McKeone, US Correspondent, Business Post
Antibody against the GABA-A receptor is a biomarker of autoimmune encephalopathy that occurs across the lifespan, and disproportionately affects children. In this test-specific episode of the "Answers From the Lab" podcast, Andrew McKeon, M.B., B.Ch., M.D., explains how Mayo Clinic Laboratories' GABA-A receptor antibody assay aids diagnosis of this serious but treatable condition.Show notes(00:32) Could you provide a little information on your role here at Mayo Clinic? (01:11) Can you give an introduction as to how GABA-A is important as the field of autoimmune neurology develops? (02:15) What type of methodology are we using in this assay? (03:17) Will there be a reflex to confirm positivity, or is that captured in that initial test? (04:22) Is either CSF or serum specimen preferable, or do we recommend both for this biomarker? (05:09) In combination with what phenotypes should this biomarker be considered? (05:37) Should a physician consider adding a GABA-A receptor standalone test to our encephalopathy, epilepsy, or pediatric evaluations, to be sure they're doing a comprehensive review? (06:25) Can you give us a little background on why this test is being launched by itself? Is Mayo Clinic Labs changing its stance on whether comprehensive evaluations are the most appropriate method? (07:30) Why has it taken so long to bring this assay live? (08:14) For exactly what type of patients should physicians consider this testing? (10:21) Should physicians add our encephalopathy evaluation every time they order GABA-A? Is the presentation you just described common or a subset? (11:24) Does that recommendation change in pediatric patients? (12:20) What does a positive result tell physicians? (12:57) Does GABA-A have a high-risk oncological association? (13:18) What does GABA-A tell a pediatric neurologist if the test comes back positive? (14:14) Should a positive GABA-A test lead a physician to a certain treatment option? (15:24) What are you most excited about in relation to the launch of this new test? (16:48) Is there anything else you'd like to add about this test?
Shane McKeon is a FDNY Lieutenant and seasoned endurance athlete. Shane joined the ranks of the FDNY immediately after 9/11 and spent many years as a firefighter in Engine Co. 84 and Ladder Co. 34 in Washington Heights before becoming a company officer. Shane has served as a lead fitness instructor at the FDNY's Probationary Firefighter School, a program manager for the FDNY's "A Day in the Life of a Firefighter" program in conjunction with the University of Pennsylvania's Wharton Business School, and as a member of the FDNY's First Line Supervisor Training Program. Shane played Division 1 baseball and two years of minor league baseball prior to joining the FDNY. Since becoming a member of the FDNY, Shane has completed 25 marathons, numerous ultra open water swims, and the Ironman on two occasions.
As VP of Production for Mattel Films, Kevin McKeon had quite the summer with the smash hit, Barbie, taking the world by storm. But he didn't land on the pink carpet overnight. He shares his journey from PA to studio exec with Hunter and how Emerson shaped every step along the way. Kevin also talks about the changes he has seen on the Emerson campus, reminisces about his time as a student and offers advice to current students about keeping an open mind and knowing their worth in the industry. Recorded on September 14, 2023.More of Hunter hunterreis.comAnd more about Emerson College at emerson.edu
Have you ever wondered how people find the strength to build a beautiful life out of adversity? If you have, prepare to be captivated by the inspiring journey of Nastasha McKeon. Nastasha's powerful narrative weaves around the core theme of resilience, emphasizing the importance of a positive mindset and reflection in facing life's challenges. In our conversation, she shares personal experiences that underscore the importance of nurturing a positive outlook to attract opportunities and how cultivating gratitude can be a potent tool in navigating challenges. We also delve into the complexities of healing and relationships, shedding light on the efficacy of self-reflection in our healing journey. The highlight of our conversation is Nastasha recounting her experience with somatic release breathwork, which helped her move toward forgiveness and self-discovery. As we traverse the themes of identity, authenticity, and forgiveness, you'll gain a rich tapestry of wisdom and insights. So join us and immerse yourself in a transformative conversation that unravels the astonishing power of resilience.PLANT FOOD IS MEDICINE BOOKwww.choicejuicery.comChoice Juicery IGNastasha McKeon IG
Hefty thanks to the wonderful and patient Stu for coming into our country and onto our podcast. Check out his twitch here.Disclaimish, Proxy Civil War, Open Mic Pick Up War, Bullet Proof Vests VS Skins, Terf War, American Hotpot, The Most Dangerous Neck of All, Step Identical Twins, Rattle Neck, Grinder of Bones, Vigilante Firefighter, B@S, Weekend at Burgers, The Second Killing, Goat Detective, Serial Manslaughterer.Gustav and Henri Volume 2 is now available to purchase in Australia here!You can support the pod by chipping in to our patreon here (thank you!)Join the other TITTT scholars on the TITTT discord server hereHey, why not listen to Al's meditation/comedy podcast ShusherDon't forget TITTT Merch is now available on Red Bubble. Head over here and grab yourselves some material objectsYou can find us on twitter at @twointankAndy Matthews: @stupidoldandyAlasdair Tremblay-Birchall: @alasdairtb and instaAnd you can find us on the Facebook right hereRecorded in the delightful and luxurious podcasting studio at Stupid Old Studios. Hosted on Acast. See acast.com/privacy for more information.
Jack to the Hall of Fame The importance of the "figure it out gene" - a special story about Jim Kaat The origin of Trader Jack The influx of analytics and its place in baseball scouting
Susie is very proud of the next crop of female swimmers coming throughSee omnystudio.com/listener for privacy information.
The Bones Brigade Audio show is back in the Deep End for our second installment of the highly anticipated SK8-TV Files! This week, we'll be diving in to the inaugural episode of the show- the almost-lost-for-all-time pilot- which rolled like a seven ply steamroller into the homes of unsuspecting Nickelodeon viewers in the summer of 1990 and kicked off what would ultimately become a beloved, if short-lived institution in skateboarding. To assist Matt and Larry in this epic review, we're welcoming back the one and only Peter McKeon; our BBAS016 special guest, Powell Peralta alum, Emmy Award winning director and guy who happens to have his name in the credits of this very episode of SK8-TV. How'd he get there? How high can Natas ollie? What was the world premiere of Ban This really like? We'll answer all these questions and more, so steal yourself a parking block, strap on your pads and join us- shall you? You can help support our show by buying us a coffee: www.buymeacoffee.com/BBASpodcast Website: www.thebonesbrigadeaudioshow.com Instagram: @thebonesbrigadeaudioshow Facebook: The Bones Brigade Audio Show Email us your questions and feedback to read on future episodes: www.thebonesbrigadeaudioshow.com/contact HAVE YOU SEEN HIM? --- Support this podcast: https://podcasters.spotify.com/pod/show/larry-ransom/support
Subscribe to Mostly Sports with Mark Titus and Brandon Walker on Youtube: https://www.youtube.com/@MostlySportsTitusandWalker?sub_confirmation=1 We comlete the pokedex on the Three Man Weave podcast as Matt Cox and Ky McKeon joinus in studio to talk through all things 2023-2024 college baskebtall season. On the back half of the episode, Mark and TJ talk high school football, new barstool shows, and the existence of aliens. Matt Cox is A quintessential high-school back-up point guard and starting hype man for all things college basketball, He is on the Three Man Weave podcast and he works as a consultant in his spare time. Matt attended a Big Ten school. Ky McKeon is decent high school turned pretty decent recreational basketball player, Ky's feathery touch from 15-18 feet is the stuff of legend. He is on the Three Man Weave podcast and he works as an Auditor for an accounting firm in his spare time. Ky attended a Big-12 turned SEC school. Follow Matt on Twitter: https://twitter.com/matty_cox Follow Ky on Twitter: https://twitter.com/Ky_3MW Show note: We'll be back with a new episode Tuesday as we continue our offseason schedule of Tuesday/Thursday episodes. Follow the show on all socials @MarkTitusShow
Rossifari Podcast - Zoos, Aquariums, and Animal Conservation
Today, the Safari heads back to my home aquarium, Adventure Aquarium in Camden, NJ, to start three weeks of wonderful and different interviews. We start with Colleen McKeon, a biologist who came on the podcast to talk about frogs. Of course, being me, I didn't let her get to frogs until more than half way through the interview, but once I did, she shared a ton of really cool stuff with me about them! We also spent time talking about turtles, a very special octopus named Charlie, and the overall vibe of Adventure Aquarium! EPISODE LINKS: @adventureaquarium on socials adventureaquarium.com ROSSIFARI LINKS: patreon.com/rossifari to support the pod and hear bonus content from this episode Rossifari.com @rossifari on socials @rossifaripod on TikTok
If you've ever been interested in making your own audio dramas this is the episode for you! Our guest is Chris McKeon, listen to his story co-authoring a novel, recording Dr. Who audio dramas and moving into fanfilms! Chris never stops and has brilliant advice for anyone wanting to follow in his footsteps! Talking Codswallop can be found on ALL social media: @CodswallopPod and we are on YOUTUBE too!!! :)
Gael McKeon interviews Jason about the origins of the podcast, the experience of putting out 1000 episodes, and plans for the podcast's future. Enjoy! Subscribe to the podcast to get these interviews delivered to you automatically! Connect with us: all things double bass double bass merch double bass sheet music Thank you to our sponsors! Carnegie Mellon University Double Bass Studio – The School of Music at CMU highly values each and every individual who wants to be a part of an innovative fine arts community immersed in a top research university. Every week each student receives private lessons and participates in a solo class with Micah Howard. Peter Guild, another member of the PSO, teaches Orchestral Literature and Repertoire weekly. They encourage students to reach out to the great bassists in their area for lessons and direction. Many of the bassists from all of the city's ensembles are more than willing to lend a hand. Every year members of the Symphony, the Opera and the Ballet give classes and offer our students individual attention. Click here to visit Micah's website and to sign up for a free online trial lesson. Dorico - Unlock Dorico for iPad – For Life! Want to enjoy all of Dorico for iPad's subscription-only features – including support for unlimited players, freehand annotations in Read mode with Apple Pencil, support for third-party Audio Unit plug-ins, and much more – but don't want to pay a monthly or annual fee? Dorico for iPad now provides a lifetime unlock option, so you can access all current and future subscription-only features for a single, one-off in-app purchase. Visit the App Store today and unlock Dorico for iPad for life! theme music by Eric Hochberg
Today we're catching up with three self-advocates from previous episodes! Advocating for the Down syndrome community from the steps of Capitol Hill we catch up with self-advocates Kayla McKeon, Matthew Schwab, and Charlotte Woodward! We were so excited to chat with them during the National Down Syndrome Society's Down Syndrome Advocacy Conference in Washington DC! From advocating equal rights in employment, healthcare, and education for people with Down syndrome these self-advocates are putting faces and names lobbying for these legislative priorities! They share the bills they're passionate about and we catch up on the fun and interesting things they've been up to. From bocce ball, to ballroom dancing, to graduating college these incredible self-advocates have been busy since we last talked to them! Friends, you're going to love this episode! --- SHOWNOTES: Learn more about the Legislative Priorities that NDSS Book Matthew Schwab for your next speaking engagement! Kayla McKeon Episodes: 17. Self Advocacy - Down Syndrome in DC with Kayla McKeon! 92. Politics & Down Syndrome w/Kayla McKeon & Ashley Helsing Matthew Schwab Episodes: 66. Public Speaking & Self Advocacy w/Matthew Schwab 183. Following the Lead of Self-Advocates (ft. Matthew Schwab) Charlotte Woodward Episodes: 160. Organ Transplant Discrimination Against People with Disabilities (ft. incredible advocates!) Friends, grab your narrative shifting gear over on The Lucky Few Merch Shop and use code PODCAST for 10% off! LET'S CHAT: Email hello@theluckyfewpodcast.com with your questions and Good News for future episodes. HELP US SHIFT THE NARRATIVE: Interested in partnering with The Lucky Few Podcast as a sponsor? Email hello@theluckyfewpodcast.com for more information! --- Send in a voice message: https://podcasters.spotify.com/pod/show/theluckyfewpod/message Support this podcast: https://podcasters.spotify.com/pod/show/theluckyfewpod/support
Friends, next week many of us are headed to DC for the NDSS Down Syndrome Advocacy Conference! Take a (re) listen to this fantastic episode! The last time we chatted with Kayla McKeon back in November 2018, she was lobbying for the ABLE to Work act that allows individuals with disabilities to save money without losing their benefits. Today, the act has passed, but Kayla (the first registered lobbyist with Down Syndrome) has certainly not stopped working hard! Her and Ashley Helsing are part of the National Down Syndrome Society's policy team that lobbies on Capitol Hill and advocates for Down Syndrome in DC! They're telling us all about what matters most for people with disabilities in the current political world: Covid-19 relief packages, marriage equality, meaningful employment, virtual school, and so much more. --- SHOW NOTES Follow Kayla McKeon on Instagram Listen to our first episode with Kayla: Self-Advocacy in DC w/Kayla McKeon Keep up with The National Down Syndrome Society Instagram Tik Tok #DSvotes movement Public policy and DS SHOP: Friends, grab your narrative shifting gear over on theluckyfew.co and use code PODCAST for 10% off! LET'S CHAT: Email hello@theluckyfewpodcast.com with your questions and Good News for future episodes. HELP US SHIFT THE NARRATIVE: Interested in partnering with The Lucky Few Podcast as a sponsor? Email hello@theluckyfewpodcast.com for more information! --- Send in a voice message: https://podcasters.spotify.com/pod/show/theluckyfewpod/message Support this podcast: https://podcasters.spotify.com/pod/show/theluckyfewpod/support