Podcasts about Propranolol

Welcome to Episode 45 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Show Notes for Episode 45 of “The 2 View” – All things toxicology: the intoxicated patient, propranolol overdose and suicide, snake bites, and a special guest. Segment 1 – The intoxicated patient Kaufman J, Fitzpatrick P, Tosif S, et al. Faster clean catch urine collection (Quick-Wee method) from infants: randomised controlled trial. BMJ. The BMJ. Published April 7, 2017. https://www.bmj.com/content/357/bmj.j1341 Kraaijvanger N, Raven W, van Dijken T, Gresnigt F. The PIRATE mnemonic: providing a structured approach in the care for intoxicated patients at the emergency department. Int J Emerg Med. Educational Advances in Emergency Medicine. BMC: Part of Springer Nature. Published March 1, 2024 https://intjem.biomedcentral.com/articles/10.1186/s12245-024-00606-4 Thiessen P. A simple new technique for collecting urine in infants. Thischangedmypractice.com. The University of British Columbia. Faculty of Medicine: This Changed My Practice (TCMP) by UBC CPD. Published November 18, 2015. https://thischangedmypractice.com/new-technique-for-collecting-urine-in-infants/ Van Oyen A, Barney N, Grabinski Z, et al. Urine Toxicology Test for Children With Altered Mental Status. Aap.org. Pediatrics. Case Reports. American Academy of Pediatrics: Dedicated to the Health of All Children. Published October 6, 2023. https://publications.aap.org/pediatrics/article/152/5/e2022060861/194346/Urine-Toxicology-Test-for-Children-With-Altered?autologincheck=redirected Segment 2 – Propranolol overdose and suicide Khalid MM, Galuska MA, Hamilton RJ. Beta-Blocker Toxicity. In: StatPearls. StatPearls Publishing. NIH: National Library of Medicine – National Center for Biotechnology Information. Published July 28, 2023. https://www.ncbi.nlm.nih.gov/books/NBK448097/ Srettabunjong S. Fatal Self-Poisoning With Massive Propranolol Ingestion in a Young Male Physician. Am J Forensic Med Pathol. PubMed®. NIH: National Library of Medicine – National Center for Biotechnology Information. Published September 2017. https://pubmed.ncbi.nlm.nih.gov/28691951/ Segment 3 – Snake bites Rohl S, Meredith M, Anderson, T, et al. Comparing the Use of Crotaline-Polyvalent Immune Fab (Ovine) Versus Observation in Children. Pediatric Emergency Care: Dedicated to the Care of the Ill or Injured Child. Lww.com. Published November 2024. https://journals.lww.com/pec-online/abstract/2024/11000/comparingtheuseofcrotalinepolyvalentimmune.19.aspx Snake bites. Wikem.org. WikiEM. Last edited March 17, 2021. https://wikem.org/wiki/Snake_bites Toxicology resources Goldfrank LR, Flomenbaum NE, Howland MA, et al. Goldfrank's Toxicologic Emergencies. 8th ed. McGraw-Hill Medical; 2006. Katz K, O'Connor A, Amaducci AM. EMRA and ACMT Medical Toxicology Guide: 2nd Edition.; 2022. National Poison Data System. Poisoncenters.org. America's Poison Centers: Treatment, Education, Prevention. Accessed April 9, 2025. https://poisoncenters.org/national-poison-data-system Poison Control: National Capital Poison Center. Poison.org. Accessed April 9, 2025. https://www.poison.org/ Segment 4 – Special guest: Nancy Denke, DNP, ACNP-BC, FNP-BC, FAEN, CEN, CCRN, of Arizona Linkedin.com. Accessed April 9, 2025. https://www.linkedin.com/in/nancy-denke-dnp-acnp-bc-fnp-bc-faen-a62851 Nancy Denke, DNP, ACNP-BC, FNP-BC, FAEN, CEN, CCRN, of Arizona. ENA Hall of Honor. Published July 26, 2024. Accessed April 9, 2025. https://hall-of-honor.org/nancy-denke PodBean Development. Talking Toxicology: A Recipe for Disaster (Nancy Denke). BCEN & Friends Podcast. PodBean. Published March 7, 2023. https://bcenandfriends.podbean.com/e/talking-toxicology-a-recipe-for-disaster-nancy-denke/ *Recurring Sources * Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

FDA say there are reports that diabetes patients are missing critical safety data from their smartphone devices; A wearable continuous apomorphine infusion device has been approved for Parkinson disease ‘off' periods; New migraine and pain treatments get the green light; And a study suggest propranolol may cut stroke risk in certain patients.  

We all what to win in life, right? That's why we have life hacks…to beat the system. Sometimes those tricks are tremendously successful while some other random hack can be- well, just WACK. Such is the case for LABOR HACKS! We all want our inductions and augmentations of labor to be successful, and there have been some labor hacks promoted throughout the years. But is there evidence of their effectiveness? Is a Pitocin break effective at kickstarting the uterus back up? We will cover that in this episode. PLUS, we will highlight two new publications, both from AJOG MFM which have just been released (September 2024; October 2024): Can “pretreatment” with calcium help with labor? What about the use of propranolol? Listen in for details.

The symptoms of irritability associated with autism spectrum disorder (ASD) include aggression, tantrums, self-injury, and disruption. Propranolol, a beta-blocker, has accumulated much anecdotal evidence as a promising option for symptoms of these disorders, but well-designed studies are rare. Dr. Eric London is the lead author of the article “High-dose propranolol for severe and chronic aggression in autism spectrum disorder: A pilot, double-blind, placebo-controlled, randomized crossover study,” which is published in the September-October 2024 issue of the Journal of Clinical Psychopharmacology. The article describes its effectiveness in decreasing aggression in individuals with ASD. As this was a small study, a larger clinical trial is needed. Dr. London is director of Autism Treatment Research at the New York State Institute for Basic Research. In this podcast, he offers extensive background on treatment challenges and the difficult core symptoms of ASD.

Content warning: This podcast discusses themes around suicide. Dr Hayley Gorton in conversation with Dr Piyush Pushkar on the subject of the recent BJPsych Open paper “Involvement of propranolol in suicides: A cross-sectional study using Coroner-Reported Data”. View the paper here: https://doi.org/10.1192/bjo.2024.714 Authors: Hayley C. Gorton, Charlotte Archer, Thikra Algahtani, Faraz Mughal, Caroline S. Copeland Follow us on Twitter @TheBJPsych #BJPOpen Podcast transcripts available: bit.ly/3CXSijb Disclaimer: BJPsych Open is not responsible for statements made by podcast contributors. Unless so stated, the content of this podcast does not necessarily reflect the views of the Editor-in-Chief or the Royal College of Psychiatrists. UK Resources mentioned in the podcast: Samaritans https://www.samaritans.org Mind https://www.mind.org.uk/

In this podcast recorded in early June, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) ignore the UK general election, the T20 cricket world cup and the European football championship and talk about the July 2024 issue of DTB. They discuss the editorial that highlights trial data showing that dupilumab had a modest effect on reducing COPD exacerbations, and question whether more drugs or greater investment in pulmonary rehabilitation and smoking cessation services are a better use of resources. They review a coroner's prevention of future deaths report that highlights the need to raise awareness of the dangers of propranolol overdose. The main article discusses the management of exacerbations of COPD in primary care.   Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page. If you want to contact us please email dtb@bmj.com. Thank you for listening.  

This episode of "Heart to Heart with Anna" features a very special heart mom. Kelsi Rogers talks about the surprising circumstances around her son's heart condition. Born with an electrical problem in his heart, Jett has already faced life-and-death situations several times in his short life. Not even three years old yet, he has undergone an ablation and an open-heart surgery.Tune in to find out what kind of heart defect Jett has, why the ablation was so extensive, and what kind of surgery eventually saved his life.Following the interview with Kelsi Rogers, co-editors Megan Tones and Anna Jaworski read the last half of Chapter Seven: Facing My Mortality from their new book The Heart of a Heart Warrior Volume Two: Endurance.Links mentioned in this podcast:HeartFelt: https://www.facebook.com/heartfeltscreeningTiny Tickers Trot: https://runsignup.com/Race/Events/CA/Chico/TinyTickersTrotBaby Hearts Press: https://www.babyheartspress.com (for more information on the book The Heart of a Heart Warrior and more!)To sign up for a Baby Hearts Press Book Study, visit our website here: https://www.babyheartspress.com/volume-2Become a Supporter of the Podcast: https://www.buzzsprout.com/62761/supporters/newSupport the showAnna's Buzzsprout Affiliate LinkBaby Blue Sound CollectiveSocial Media Pages:Apple PodcastsFacebookInstagramMeWeTwitterYouTubeWebsite

In this solo episode Craig shares his current thoughts on MDMA medicalization, sleep meds, ADD, motivation vs self-discipline, benzos, how long to stay on psych meds, a change and a proposed addition to his top 10 med list, borderline vs bipolar, and marriage.Bringing Therapy into Med Management-- An intensive training with Dr.  Hhttps://www.craigheacockmd.com/training/BFTA on IG @backfromtheabysspodcasthttps://www.instagram.com/backfromtheabysspodcast/BFTA/ Dr. Hhttps://www.craigheacockmd.com/podcast-page/

On this episode of the Real Life Pharmacology podcast, I take a dive into the most common mechanisms of drug interactions. Below I list some of the common drug interactions seen in practice and how they work! Opposing Effects Many drugs will work on various receptors throughout the body. To use as an educational point, there is no better example to point to than the beta receptor. Beta-blockers are frequently used in clinical practice for their ability to lower blood pressure and slow the heart rate. Both of these beneficial actions are primarily achieved by blocking the effects of beta-1 receptors. Some beta-blockers have action on alternative beta receptors. Propranolol is one such beta-blocker that is classified as a non-selective beta-blockers. This means that in addition to the positive effects on beta-1 receptors, it can also have blocking effects on beta-2 receptors. The blockade of the beta-2 receptor by propranolol can also be life-changing. It can directly oppose beta-2 agonists like albuterol from having their beneficial effects of opening up the airway. Enzyme Inhibition Medication metabolism is arguably the largest and most clinically significant source for drug interactions. Medications that are primarily metabolized by enzymes in the liver can be greatly affected if we affect how those enzymes work. CYP3A4 is one of the most well studied and well-known enzymes that can impact hundreds to maybe even thousands of drugs. Apixaban is an oral anticoagulant that is broken down at least in part by CYP3A4. By using a CYP3A4 inhibitor like erythromycin, there is the potential to raise concentrations of apixaban. This could lead to a higher risk of bleeding. Enzyme Induction Carbamazepine is a drug that you must know. This drug is a potent enzyme inducer. This differs significantly from an enzyme inhibitor and will have the exact opposite clinical effect. Drugs that are inactivated by liver enzymes will be inactivated more quickly in a patient taking an enzyme inducer. Going back to our prior apixaban example above, carbamazepine can induce CYP3A4 and facilitate a more efficient and swifter breakdown of the drug. Bleeding will be less likely. The risk for treatment failure, usually in the form of a blot clot, will be more likely.  Here's more information from the past on carbamazepine. Alteration in Absorption Binding interactions can be consequential and are one of the most common types of drug interactions. Many medications have the potential to bind one another in the gut. This can lead to lower concentrations of a specific medication. Calcium and iron are two of the most common examples of medications that can bind other drugs. Alteration in Protein Binding By remembering that unbound drug is an active drug, you should appreciate the risk for protein binding alterations. A significant number of medications can bind proteins in the bloodstream. As this occurs, that drug is not freely available to create physiologic effects. When another medication is added that can also bind these proteins, this can displace other medications and increase the quantity of free drug in the bloodstream. This essentially allows for enhanced physiologic effects. Warfarin is a medication that is highly protein-bound. When another drug is added that can kick warfarin off of those protein binding sites, it can free up warfarin which will increase the likelihood of elevating the patient's INR and increase their bleed risk. Alteration in Renal Elimination Some drugs can alter the way other medications are eliminated through the kidney. Chlorthalidone, like all thiazide diuretics, has the potential to block the excretion of lithium from the kidney. This can lead to lithium toxicity. This type of interaction, while significant, is much less common than drug interactions involve the liver and CYP enzyme pathways.   Effects on Transporters One of the last types of drug interactions is the effe...

It has been well reported that rates of elective induction have risen nationally and internationally since the adoption of the ARRIVE trial. But as medicine is at times controversial, some studies have suggested an increase in cesarean section rates with elective induction of labor at 39 weeks. While we will briefly discuss those studies, they are not the focus of this episode. However, as induction of labor becomes more common place, there has been renewed interest in use of adjuvant medications to augment induction success. One of those medication is propranolol. Can giving a beta-blocker help with uterine contractility? The data is conflicting with recent evidence saying “No!“. In this episode, we're going to put the evidence on trial and present both arguments: one as plaintiff, and one argument as the defense for our shared client, which is propranolol. Is propranolol guilty of its charges of being a labor stimulant? Or is it innocent of all charges? Let's let the data decide.

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayIn this episode, I will be briefly describing each one of the most important Non Selective Beta Blockers namely. Propranolol, Timolol, Nadolol and Pindolol.These would be the whole episode talk and it will be very beneficial to comprehend the various uses, precautions, clinical applications and ADRs and drug interactions and combinations related to these drugs. The special features of each of the drugs i sthe highlight of the episode!!For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine.It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!Please leave Review on Apple podcasts!My E-Newsletter sign up at Website!Connect on Twitter & Instagram!My books on Amazon & Goodreads!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayIn this episode, I will be briefly describing each one of the most important Non Selective Beta Blockers namely. Propranolol, Timolol, Nadolol and Pindolol.These would be the whole episode talk and it will be very beneficial to comprehend the various uses, precautions, clinical applications and ADRs and drug interactions and combinations related to these drugs. The special features of each of the drugs i sthe highlight of the episode!!For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine.It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! Please leave Review on Apple podcasts! My E-Newsletter sign up at Website! Connect on Twitter & Instagram! My books on Amazon & Goodreads!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayIn this episode, I will be discussing the very much anticipated and ought to know therapeutic uses and indications of Beta receptor antagonistic agents in general as well as specific term. As far as latter explanation is concerned, I will be picking up "Propranolol" for my talks!! It will all in details enough for you all to comprehend well!These would be the highlights of this episode while in next episode I will be arriving with a fresh, new, factual and informative bunch of therapeutic uses of different  Beta blockers other than Propranolol. Till then......Abientot! ........Aurevoir!!For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine.It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! Please leave Review on Apple podcasts! My E-Newsletter sign up at Website! Connect on Twitter & Instagram! My books on Amazon & Goodreads!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayIn this episode, I will be discussing the very much anticipated and ought to know therapeutic uses and indications of Beta receptor antagonistic agents in general as well as specific term. As far as latter explanation is concerned, I will be picking up "Propranolol" for my talks!! It will all in details enough for you all to comprehend well!These would be the highlights of this episode while in next episode I will be arriving with a fresh, new, factual and informative bunch of therapeutic uses of different Beta blockers other than Propranolol. Till then......Abientot! ........Aurevoir!!For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine.It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!Please leave Review on Apple podcasts!My E-Newsletter sign up at Website!Connect on Twitter & Instagram!My books on Amazon & Goodreads!

To get a hold of my books, you can find Memorizing Pharmacology Second Edition HERE or Memorizing Pharmacology Mnemonics HERE In this episode, I go over how you can use PRO BAM CARLAB to remember the beta blocker generations and what that means for pharmacology indications and adverse effects.  

Download the cheat: https://bit.ly/50-meds  View the lesson:     Generic Name propranolol Trade Name Inderal Indication hypertension, angina, arrhythmias, cardiomyopathy, alcohol withdrawal, anxiety Action blocks Beta 1 and 2 adrenergic receptors Therapeutic Class antianginal, antiarrhythimic (class II beta blockers), antihypertensive, headache suppressant Pharmacologic Class beta blocker Nursing Considerations • contraindicated in CHF, pulmonary edema, cardiogenic shock, bradycardia, heart block • monitor hemodynamic parameters (HR, BP) • may cause bradycardia, CHF, pulmonary edema • masks symptoms of hypoglycemia associated with diabetes mellitus • advise to change positions slowly to prevent orthostatic hypotension • instruct patient on how to take blood pressure • stopping abruptly may result in life threatening arrhythmias • monitor daily intake and output • advise patient to notify physician for difficulty breathing

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.07.519404v1?rss=1 Authors: Fang, H., Wang, Y., Liu, L., Cheng, K., Li, P., Tan, Y., Hao, X., Mei, M., Xu, X., Yao, Y., Zan, F., Wu, L., Zhu, Y., Xu, B., Huang, D., Wang, C., Tan, X., Qian, Z., Chen, X.-W. Abstract: Host-based antivirals could offer broad-spectrum therapeutics and prophylactics against the constantly-mutating viruses including the currently-ravaging coronavirus, yet must target cellular vulnerabilities of viruses without grossly endangering the host. Here we show that the master lipid regulator SREBP1 couples the phospholipid scramblase TMEM41B to constitute a host "metabolism-to-manufacture" cascade that maximizes membrane supplies to support coronaviral genome replication, harboring biosynthetic enzymes including Lipin1 as druggable viral-specific-essential (VSE) host genes. Moreover, pharmacological inhibition of Lipin1, by a moonlight function of the widely-prescribed beta-blocker Propranolol, metabolically uncouples the SREBP1-TMEM41B cascade and consequently exhibits broad-spectrum antiviral effects against coronaviruses, Zika virus, and Dengue virus. The data implicate a metabolism-based antiviral strategy that is well tolerated by the host, and a potential broad-spectrum medication against current and future coronavirus diseases. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Welcome to PICU Doc On Call, A Podcast Dedicated to Current and Aspiring Intensivists. I'm Pradip Kamat coming to you from Children's Healthcare of Atlanta/Emory University School of Medicine and I'm Rahul Damania from Cleveland Clinic Children's Hospital. We are two Pediatric ICU physicians passionate about all things MED-ED in the PICU. PICU Doc on Call focuses on interesting PICU cases & management in the acute care pediatric setting so let's get into our episode: Welcome to our Episode: A Somnolent Toddler. Here's the case: A 2 yo M presents to the PICU after being found increasingly sleepy throughout the day. The toddler is otherwise previously healthy and was noted to be in his normal state of health prior to today. The mother dropped the toddler off at his Grandmother's home early this morning. Grandmother states that he was playing throughout the day, and she noticed around lunchtime the toddler stumbles around and acts more sleepy. She states that this was around his nap time so she did not feel it was too out of the ordinary. The toddler 1 hr later was still very sleepy, and the grandmother noticed that the toddler had some shallow breathing. She called mother very concerned as she also found her purse open where she typically keeps her pills. The grandmother has a history of MI and afib as well as hypertension. She is prescribed a multitude of medications. Given the child's increased lethargy, the grandmother presents the patient to the ED. In the ED, the child is noted to be afebrile with HR 55 & RR of 18. His blood pressure is 78/40. On exam he has minimal reactivity to his pupils, he has shallow breathing and laying still on the bed. A POC glucose is 68 mg/dL. Acute resuscitation is begun and the patient presents to the PICU. To summarize key elements from this case, this patient has: Drowsiness Bradycardia Normotension This is in the setting of being at grandma's home and having access to many medications Given the hemodynamic findings and CNS obtundation, this patient's presentation brings up concern for a clonidine or beta-blocker ingestion. This episode will be organized: Beta-Blocker poisoning We will also examine other medications that potentially can be toxic to a toddler (one pill can kill) present in Grandma's purse which include: TCA, CCB, Opioids, oral anti-diabetic agents, digoxin, etc. The presence of a grandparent is a risk factor for unintentional pediatric exposure to pharmaceuticals commonly referred to as the Granny Syndrome. Grandparents' medications account for 10% to 20% of unintentional pediatric intoxications in the United States. To kids, all pills look like candy. Let's start with a multiple choice. An overdose of which of the following medications may mimic the presentation of Metoprolol overdose? A. Verapamil toxicity B. Ketamine toxicity C. Valium toxicity D. Lithium toxicity The correct answer is A, verapamil toxicity. Verapamil is a non DHP CCB. It acts at the level of the SA and AV node similar to Metoprolol, a beta-1-specific antagonist. Both cause bradycardia and AV node block. Valium though a CNS depressant, can cause CV depression as well, however, would have fewer changes on the conduction system compared to a non-DHP CCB.  What is the mechanism of toxicity with beta-blockers? Beta-blockers are competitive inhibitors at beta-adrenergic binding sites, which results in decreased production of intracellular cyclic adenosine monophosphate (cAMP) with a resultant blunting of multiple metabolic and cardiovascular effects of circulating catecholamines. They attenuate the effect of adrenergic catecholamines on the heart Decrease inotropic and chronotropic response. Some drugs like Propranolol can act as Na channel blockers (myocyte membrane stabilizing activity) at high doses resulting in arrhythmias and seizures. Toxic doses of drugs like Sotalol can result in K channel blockade giving rise to prolonged QT and risk for...

Trade: Inderal Class: Beta Blocker MOA: Nonselective Beta antagonist that binds with both the beta1 and beta 2 receptors. Inhibits the strength of the hearts contractions, as well as decreases heart rate resulting in decreased cardiac O2 consumptionIndication: Angina, reentry SVT, Atrial Fibrillation, Atrial Flutter. Contraindication: Cardiogenic shock, Heart failure, AV block, bradycardia, pulmonary edema, sick sinus syndrome.Side effects:  Bradycardia, AV block, Bronchospasm, hypotension. Dosing:Adult: 1-3mg IV/IO Slow IVPPediatric: 0.01 to 0.1mg/kg slow IVP

Margie Taylor's son, Fort Hood Spc. Joey Lenz, 32, a tactical power generation specialist assigned to the 3rd Armored Brigade Combat Team, 1st Cavalry Division, was found dead in his barracks room on the morning of Feb. 1. 2022. Lenz, 32, who enlisted in 2017, was expected to leave the Army in mid-March. “He already had a job, he was happy, everything was good, and then he died,” she said. His mother said her son enjoyed his Army life, that he didn't want to leave, but he was being “pushed out.” Since his death, Taylor learned her son was being bullied and targeted by a captain who has since been moved. Taylor said Lenz's staff sergeant and the lieutenant colonel were also moved in recent weeks. Between Christmas, when her son visited her in Conroe, Texas for the holiday, and his death on Feb. 1st, Taylor was told her son has prescribed four medicines: Trazadone, Cyclobenzaprine, Fluoxetine, and Propranolol leading her to believe a drug reaction known as serotonin syndrome may have contributed to his death. During a memorial for Lenz at Fort Hood in February, Taylor said she met privately with over 30 soldiers who wanted to share happy memories of her son. "They said you need to get justice for Joey. They said, ‘We know he didn't just die. There's something going on and they overmedicate here.' Taylor said she was informed by Fort Hood CID Special Agent in Charge Maria Thomas that CID had completed its investigation and that her son had died of “mixed drug interaction.” “I believe there is more to the story,” Taylor said.

People don't like how they look on Zoom - with Dr. Kim Nichols! - Timolol = propranolol? - Timolol *does* work for hemangiomas? - Spironolactone for androgenetic alopecia - Bile acids inhibit IL-17 For more on Dr. Nichols: https://kimnicholsmd.com/ Twitter: @NicholsMD_Derm https://www.facebook.com/NicholsMD/ Connect with us! - Web: https://dermaspherepodcast.com/ - Twitter: @DermaspherePC - Instagram: dermaspherepodcast - Facebook: https://www.facebook.com/DermaspherePodcast/ - Check out Luke and Michelle's other podcast, SkinCast! https://healthcare.utah.edu/dermatology/skincast/ Luke and Michelle report no financial conflicts of interest… BUT check out our friends at: Kikoxp.com (a social platform for doctors to share knowledge) https://www.levelex.com/games/top-derm (A free dermatology game to learn more dermatology!)

A rapid review of infantile hemangioma for the plastic surgery learner. In this episode we review:Evaluation and management of the infantile hemangioma patientFeedback is always appreciated. Comments, questions, suggestions, or corrections can be sent to jakemarksmd@gmail.comReferences:Greene AK. Management of hemangiomas and other vascular tumors. Clin Plast Surg. 2011;38(1):45-63.Sugimoto A, Aoki R, Toyohara E, Ogawa R. Infantile Hemangiomas Cleared by Combined Therapy With Pulsed Dye Laser and Propranolol. Dermatol Surg. Leung AKC, Lam JM, Leong KF, Hon KL. Infantile Hemangioma: An Updated Review. Curr Pediatr Rev. 2021;17(1):55-69.

On this episode, I discuss propranolol pharmacology, adverse reactions, and important drug interactions you should know.

Short-term po steroids carry risks in children – Derm lifestyle modifications – Dupi for LP – Dermoscopy can determine the species in tinea capitis – Propranolol works for ulcerated hemangiomas – Rosacea fulminans herpeticum Http://www.dermaspherepodcast.com/ Luke and Michelle report no conflicts of interest.

AA consensus: Labs and Bx - Timolol doesn't work for hemangiomas? - Fecal transplant for AA - Ulcerated hemangiomas: Go easy on the propranolol - MTX best for PRP? - Store-and-forward triage can save money http://www.dermaspherepodcast.com Luke and Michelle report no conflicts of interest.

Leo's channel: https://www.youtube.com/c/LeoandLongevity Derek's channel: https://www.youtube.com/channel/UCoR7CHkMETs3ByOv74OAbFw Steve's channel: https://www.youtube.com/user/VigorousSteve TIMESTAMPS: 0:00 intro 0:29 Connor Murphy/ Ayahuasca and DMT 1:36 Kenny KO and Connor 2:10 Leo on psychedelics/ his friend 3:38 Steve on psychedelics 5:29 Marijuana and schizophrenia/ More on Connor 7:45 Man cutting his genitals off on drugs 9:30 Screen sharing on Zoom 9:58 Leo's manic Canadian friend 10:47 Derek will avoid psychedelics 12:13 Derek on being ambitious 13:29 Losing your ego 14:12 How Leo hurt his finger 16:42 Antoine's Vaillant bicep and Olympia placing 19:06 Derek's bodybuilding genetics 20:13 Why Derek stopped doing steroids/ Making money as a bodybuilder 23:16 GH15, Antoine, and Frank Mcgrath 24:44 Bodybuilding, dieting, and tren 26:25 Recovery from injury Beta-blockers either before or after a surgery Nebivolol, collagen and gelatin protein, Propranolol, 29:03 Angiogenesis BPC 157, TB500, erythropoietin 31:06 Growth factors and hair loss/ Icing and cooling injuries 32:06 MK677, ghrelin  and surgeries/ MK677, GH, and IGF1 34:05 MK677, Ghrelin, PTSD, and Insulin 39:22 Jujimufu and Greg Ducette/Canadian accents 43:34 People being hyper-critical of people in the fitness industry. 44:49 Jujimufu, arm wrestling, and stomach distension 47:53 Leo's GH experience 49:31 Jujimufu's genetics 51:06 Looking like you work out while wearing a shirt 52:25 Anabolic pathways 53:30 Dallas McCarver autopsy/ Anthony Roberts ban 58:20 Dallas McCarver organs 1:00:21 Leo's friend taking large sums of steroids/ Derek on the autopsy 1:07:00 Derek and Steve on blood and urine drug tests/ Tren cough 1:11:10 What steroids do to your heart Dislipidemia, HDL goes down, HDLC decreases by approx 50%, APO A1 decreases by 33-41%, increases LDLC by approx 36% Reduce lipoprotein [a] 1:12:41 Homocysteine blood tests/ Chris Masterjohn  Creatine, Choline, B vitamins 1:13:50 More on Lipoprotein [a] Niacin, Repatha, and steroids 1:15:01 Derek's client with strange test results 1:15:54 Hypercholesterolemia  Homozygous APOCIII, CETP, and APOE4 1:17:33 Steroids, left ventricular systolic function, left ventricular diastolic function, and heart hypertrophy. 1:19:15 Heart FMRI 1:20:28 Impaired tonic cardiac autonomic regulation, and Clenbuterol 1:22:32 Leo's list of tests and genetics 1:23:25 Statins, Ezetimibe, and cholesterol 1:25:00 Automated gene searches 1:26:09 Statins and natural status 1:27:24 Lowering LDL and extending life PCSK9 inhibitors, Bempedoic acid, Ezetimibe, and Statins 1:28:41 Steve on Ezetimibe 1:29:32 Leo on Statins (the good and the bad) Pitavastatin, Rosuvastatin crestor ,livalo, lipitor 1:33:56 Telmisartan, Valsartan, Azilsartan and Irbesartan 1:39:17 Diuretics, bloating, and Estrogen 1:41:28 Hyperkalemia, Potassium and drug interactions 1:43:20 Minoxidil as a potassium channel opener and microneedling 1:45:49 Steve doesn't like hair 1:47:40 Leo's hypothesis on hair loss/ Derek on hair loss 1:54:25 Topical dutasteride 1:55:35 70-year-old women and balding 1:56:45 Steve on being secure with hair loss 2:00:40 Men and size 2:02:04 Pre-workout androgens Anadrol, Dianabol, Superdrol and Anadrol 2:08:26 Taking short-acting compounds around your workout 2:10:00 How steroids cause liver cancer and why Anavar doesn't cause it 2:11:56 Dianabol back pumps 2:13:19 Egyptian bodybuilders 2:14:52 Steve's fasting protocols 2:18:15 Reasons to fast 2:20:44 Leo's reasons to fast/ Satchin Panda's book/Valter Longo's fasting-mimicking diet and Prolon 2:23:47 Proper fasts on PEDs Allopurinol 2:27:36 How Steve and Leo prepare salads 2:30:35 The discord group 2:34:19 Unhealthy relations to Youtubers 2:39:58 Epigenetics and children 2:43:14 IVF and metabolic profiles 2:45:35 Coming off of testosterone and getting back to baseline 2:46:37 Having kids at an older age (epigenetic damage over time to sperm) 2:49:42 Steve and Leo on TV 2:50:15 Past downloading services 2:54:06 Unusual pre workout supplements for more strength or a better pump 2:56:40 Why the hell are people taking Phenibut and Kratom pre workout 2:58:00 Low dose Naltrexone therapy 3:00:16 Getting over addiction 3:02:34 Gynecomastia 3:05:43 Removing your glands before you take steroids/ Problems with Nolvadex 3:08:02 Derek and Steve on their gyno experiences 3:10:45 How to deal with gyno if you don't want the surgery 3:11:56 Steve on growing your gyno, to get the surgery JOIN OUR COMMUNITY: Reddit ▶ https://www.reddit.com/r/TheLongLived/ FOR GENETIC ANALYSIS & COACHING: Website ▶ https://www.leoandlongevity.com TO READ MY ARTICLES: Blog ▶ https://www.leoandlongevity.com/blog TO FOLLOW ME ON SOCIAL MEDIA:  Instagram ▶ https://www.instagram.com/leoandlongevity Twitter ▶ https://www.twitter.com/leoandlongevity

Thanks so much James for being on our first episode AND being quizzed on thyroid anaesthesia.We hope this will be useful for anyone studying anaesthesia but especially those about to sit the ANZCA part 2 exam!The CaseYou are called down to review a patient for the evening emergency list in your tertiary hospital. 60yo female with SBO for laparotomy, looks unwellA: speakingB RR 30 sats 92% on RA 98% 6L HM O2.C 2 16G iv. HR 130, BP 100, 2L CSL given.D GCS 15. In 7/10 pain. Total 10 of morphine iv given by paramedics and ED in last 2 hours. Temp 38.5deg. Broad spec antibx given. E. 80kg. 150cm. BMI 35. Large goitre.How do you treat this?This is very uncommon and I would always consult endocrinology to advise!o   Supportiveo   Cool patiento   Hydrationo   Oxygen and ventilation Reduction of synthesis of thyroid hormoneo   Dexamethasone 4mg iv q8hr or hydrocortisone 100mg iv q6-8ho   Iodine: sodium iodide (1 g IV or Lugol's solution 4–8 drops orally q6–8h) or supersaturated potassium iodide solution (5 drops orally q6h)o   Iv methimazole (20mg 4-6hrly) carbimazole 20-30 enterally tdso   Propylthiouracil (200-400 mg o q6-8hrs Reduction of peripheral conversion of T4 to t3o   Propylthiouracilo   Hydrocortisoneo   propranolol 80mg o 6hrly or 5mg iv. Over 10mins  repeat 3x prn. Decrease metabolic effects of thyroido   Beta blockerso   Propranolol, esmololo   Caution in COPD. o   Maybe iv diltiazem Othero   plasma exchangePlease rate, post a review and subscribe!Check out https://anaesthesiacollective.com/education/first-part-exam/ for general information and a collection of model answersand sign up to the ABCs of Anaesthesia facebook group https://www.facebook.com/groups/2082807131964430and check out the ABCs of Anaesthesia YouTube channel for more contenthttps://www.youtube.com/c/ABCsofAnaesthesiaIf you have any questions, please email anaesthesiapodcast@gmail.com  Disclaimer:The information contained in this podcast is for medical practitioner education only. It is not and will not be relevant for the general public.This contains general information about medical conditions and treatments. The information is not advice and should not be treated as such. The medical information is provided “as is” without any representations or warranties, express or implied. The presenter makes no representations or warranties in relation to the medical information on this episode. You must not rely on the information as an alternative to assessing and managing your patient with your treating team and consultant.You should seek your own advice from your medical practitioner in relation to any of the topics discussed in this episode'Medical information can change rapidly, and the author/s make all reasonable attempts to provide accurate information at the time of filming. There is no guarantee that the information will be accurate at the time of viewingThe information provided is within the scope of a specialist anaesthetist (FANZCA) working in Australia.The information presented here does not represent the views of any hospital or ANZCA.These podcasts are solely for training and education of medical practitioners, and are not an advertisement. They were not sponsored and offer no discounts, gifts or other inducements. This disclaimer was created based on a Contractology template available at http://www.contractology.com. 

Good Morning, This is Louise. Episode 83 - Because of Flowersfeaturing music by Ana Roxanne, Meitei, and Kleinwith ambient recordings by Nomadic Ambiances programmed and produced by @small_ernst Namo Guan Shi Yin Pusa Thank you for listening

Drachma Institute channel: https://www.youtube.com/channel/UC_6asUmalBMm_MgerKvuHxQPatreon for conversations on Theories of Everything, Consciousness, Free Will, and God: https://patreon.com/curtjaimungalHelp support conversations on "when does the left go too far?": https://bit.ly/2EOR0M4Twitter: https://twitter.com/bluthefilmiTunes: https://podcasts.apple.com/ca/podcast/better-left-unsaid-with-curt-jaimungal/id1521758802DOCUMENTARY SERIES: https://www.youtube.com/watch?v=pM3G6kITdYkMEREL'S WEBSITE: https://kindtclinics.com/en/[1]: Beyond extinction: erasing human fear responses and preventing the return of fear[2]: MissingINTERVIEWERS: Peter Glinos, Faraz Honarvar, Curt JaimungalEDITED BY: Efron MonsantoTIMESTAMPS BY: Prof. Joe Velikovsky00:00 Introduction to fear extinction14:07 ​Propranolol & the blood/brain barrier18:32 ​Epigenetics & inherited fears (vs irrational/phobic fears)26:33 ​Removing the fear of Public Speaking30:36 ​PTSD33:45 Using ​psychedelics / MDMA to enhance self-treatment37:29 ​Pilot study with cigarette addiction42:31 Should we get rid of fear? What are the consequences?43:13 ​MDMA vs LSD vs Psilocybin48:07 Fear of ​silverfish50:13 ​Phobias don't always come from trauma, they can be from modelling someone else's behavior54:37 ​Prof. Kindt's groundbreaking 2009 paper, and memory engrams [1]55:34 Prof. Kindt's 2019 paper [2]58:02 ​Imagery scripting59:35 What about disgust-removal?1:00:36 ​How beta-blockers work1:02:04 The necessity of sleep for memory transcription and re-consolidation1:03:33 Prof. Kindt measures the startle reflex (emanating from the amygdala) when someone's threatened1:06:07 Testing a different beta-blocker (but it didn't pass the blood/brain barrier)1:07:12 ​Future challenges & limitations (re: fear extinction)* * *Subscribe if you want more conversations on Theories of Everything, Consciousness, Free Will, God, and the mathematics / physics of each.* * *I'm producing an imminent documentary Better Left Unsaid http://betterleftunsaidfilm.com on the topic of "when does the left go too far?" Visit that site if you'd like to contribute to getting the film distributed (in 2020) and seeing more conversations like this.

COVID Toes: Young, Healthy Patients. Delayed Reaction? Epi-phenomenon? - CsA Works for DRESS - THIS is When to Refer a Hemangioma - No Need to Monitor HR or BP When Starting Propranolol (for IH) - Normal Saline Fixes Steroid-induced Lipoatrophy - AGEP vs Pustular Psoriasis: The Truth is in the Histopath

“Creativity is finding unity in what appears to be diversity,” says Dr. Kenneth Heilman. Author of Creativity and the Brain, Heilman, a distinguished Professor Emeritus at the University of Florida, explains where creativity may reside in the brain, how it differs from raw intelligence, and how creative people actually think. Heilman has been fascinated by creativity since childhood. Almost killed by meningitis as an infant in 1938, he was saved by a doctor who had heard of a new treatment and tried it on Heilman. “Creativity has reduced a huge amount of suffering,” Heilman says. TRANSCRIPT: Intro: 0:01 Inventors and their inventions. Welcome to Radio Cade the podcast from the Cade Museum for Creativity and Invention in Gainesville, Florida. The museum is named after James Robert Cade, who invented Gatorade in 1965. My name is Richard Miles, we’ll introduce you to inventors and the things that motivate them, we’ll learn about their personal stories, how their inventions work and how their ideas get from the laboratory to the marketplace. Richard Miles: 0:38 Creativity in the brain, where can it be found? How does it differ from intelligence? And what are creative people like? I’m your host Richard Miles, today, My guest is Dr. Kenneth Heilman, distinguished professor emeritus at the University of Florida and author of surprise, a book called “Creativity and the Brain”. Welcome to Radio Cade Ken. Dr. Kenneth Heilman: 0:56 Thank you for inviting me. Richard Miles: 0:58 So Ken, like many of our guests on this show, you spent your career in Florida, but you were born in Brooklyn. So, the first thing I gotta ask is, Dodgers or Yankees? Let’s get that out of the way first. Dr. Kenneth Heilman: 1:09 Brooklyn Dodgers. But when they moved to LA, I stopped being a professional sports fan. Richard Miles: 1:16 So you didn’t switch to another team? You just gave up entirely on sports? Dr. Kenneth Heilman: 1:19 Well, you know, here was a team that was tremendously supportive and actually started integration with Jackie Robinson and what happened because they offered him a free stadium in the park and Patriot, the hell with the fans that have been watching him for all these years, we’re going to LA and I said, look, I don’t move for businesses.The hell with this I’m not watching this anymore. Richard Miles: 1:42 And that was a precursor of things, the calmest teams to abandon their cities, to go to other markets and so on during the expansion years. Okay. Well, now that we’ve got that most important question out of the way, let’s sort of dive straight into our topic. As you know, Phoebe and I, have always been interested in the neuroscience of creativity and I think the first time we met, probably about 2010, it was to get your ideas and some other folks at the University of Florida, we’re planning a big exhibit on the neuroscience of creativity. And so we needed to get smart, and we knew that you were one of the folks to talk to. So creativity is one of those terms that gets thrown around a lot and sometimes it’s defined in different ways. So why don’t I start by asking you to define creativity from your point of view, and then how does it differ from intelligence? But let’s start with that. Dr. Kenneth Heilman: 2:25 Okay. First of all, when I was in high school, I took a public speaking course, I got to seen it, but your teachings are remember, is thought by definitions and tell people how important it is. So we’ll start with the definitions. It depends where you look up creativity for different definitions. If you go to websites, for example, it says productive and mall by originality. So according to them, if I sat down in front of a word processor and randomly hit keys for days and days and days, it would be creative because it would be original. Nobody probably would hit the same keys and if I did it long enough, it would be productive, but you wouldn’t feel this would be creative. I think the best definition, but the same complete by Banowsky who said, creativity is fine in unity in what appears to be diversity. The only problem with this definition it is no mention of originality or productivity. So I think in the book and during lectures, when I define creativity is the ability to discover, understand, develop and express in a systematic fashion, novel, orderly relationships said , in other words, finding the thread that unites. Now, a lot of people in other definitions state, it must have value, and I never understood why they put it in and sure, great artists, and you never sell your painting and it burns or something. It doesn’t mean that it wasn’t creative. Even now. It has no value. So value, I’m not sure really defines it . It defines it and far as business people, but not as far as people who produced creative products. Now let me tell you about the second part. If you look at my yearbook at high school, all the way back then he says Ken Heilman wants to do medical research. And what happened when I was a little boy, I looked down at my arm and I noticed I had a scar right near the front on the top and I asked my mother, what is that mom? She said, oh, when you were an infant, you came down with meningococcal meningitis. And this was 1938 or 1939, and the doctor said we have no cure for it. He’s going to die. It turns out this doctor actually had an appointment that Columbia University and you were working on a new drug called sulfur drugs . And he actually lifted some out of the laboratory poets and my house did a cut down. That’s what the scar was for, gave it to me, and here it’s 79, 80 years later and I’m still here. And that really brought to mind how important creativity is. You inclined have suffered with diseases and so many other problems and when you think about all the wonderful things that we’ve done, when used appropriately, creativity has reduced a huge amount of suffering . So that’s why it’s always been a very important topic to me. Richard Miles: 5:31 So can you write it? Creativity is closely linked to raw intelligence, but it’s not quite the same thing? Is that correct? Dr. Kenneth Heilman: 5:38 Well, let me talk about intelligence and creativity. Okay. First of all, let me start by saying in general, when I’ve written about this, I talk about three major steps in the creative process. The first one is preparation, and that’s learning all the skills and knowledge that you need to be creative. The second one, I call creative innovation and that’s coming up with the creative ideas. And the third stage of course is production. Now I’m not going to discuss that at all, because that depends upon the domain of creativity. But what about IQ Willem , as you probably know, okay. With IQ, when initially it was early on used people call people who have IQ over 130, 140 geniuses. And genius implies that you’re tremendously creative. And it turns out there was a psychologist, I think at Stanford, whose name was Terman . And what Termin did was gave all the students and around San Francisco and all that area an IQ test that he developed called the Stanford Benet. And then he followed all these people along and it turns out some were very successful, some or just usual, but there were no Nobel prize winners that was in his genius class, but it turns out that there was two Nobel prize winners whose IQs were too low to be in term as geniuses that reached and got the Nobel prize. So one was Shockley who invented the transistor and you know what that’s meant to our world . And another one was Alvarez who helped develop the radar. They both won Nobel prizes, but they didn’t have IQs high enough to be included in terms of geniuses. So in general, people found out that later on, there was not a direct relationship between intelligence and creativity. And in general, a lot of people who’ve written about this say, you just need to be intelligent enough to learn the skills and knowledge in the creative domain that you’re doing. People have a cutoff of about 110 or 120 , but there is no direct relationship. Richard Miles: 7:53 So it’s more of a threshold factor, right? That once you reach that threshold of somewhere between 110 and 120, there’s not a correlation that the smarter you are, the more creative you are. Dr. Kenneth Heilman: 8:02 No Relationship. Now, it turns out that special talents are important. They’re very, very important. But of course, the IQ test doesn’t test special talents. So way back in the 1700s, there was a philosopher, Gall, who was actually the founder of phrenology, but Gall had two very important postulates. One postulate was that different parts of the brain perform different actions. And the second postulate was the better developed this module was, or this specific form better develop better at work. Now, what happened was Gall, was aware that our skull grew depends upon brain growth, so we said, oh, if we measured the skull, maybe we can tell about people and what they are capable of doing. The problem with that is it became a pseudoscience and all these people were making all these crazy suggestions, but it turns out a neurologist in France in the mid- 1800s, Paul Roca, heard a student of Gall’s talking about the importance for the frontal lobes and speech and he had a patient in the hospital who had a stroke sometime before was actually dying of, I think, tetanus and the patient had trouble speaking. He could understand, but he couldn’t get out the speech. The patient died and sure enough, he had a lesion in his frontal lobe. And then, in the second paper, Paul Broca examined eight people who had problems with speech from strokes, all eight of them, they were right-handed and all eight of them had left hemisphere strokes. So that provided a positive finding that really in some way, supported Gall’s, hypothesis. And we know that the left hemisphere understands speech. One of my mentors or Norman, Geschwind looked at a huge amount of people’s brains at the auditory cortex in the left hemisphere and the right hemisphere. And he found that the auditory cortex was actually bigger in most people in the left hemisphere, but even with great geniuses, sometimes their brains are different, but this hasn’t really been evaluated today. Richard Miles: 10:16 I just wanted to interject or ask a question about the role of the left hemisphere and at least the theory and how that contributes to creativity. Cause I remember in your book, which came out in 2010, it came out. I remember you described a number of what to me were surprising associations with higher creativity, including, for instance, being lefthanded, epilepsy, having dyslexia, being slow, and learning to speak, mental illness. And if I understood correctly, the general theory sort of connecting those was a suppression of, or damage to the left hemisphere actually allowed the right hemisphere of the brain more license, I guess and that may contribute to creativity. Dr. Kenneth Heilman: 10:57 You’re jumping ahead a little bit. Okay. There have been studies for example, by Miller who’s out in San Francisco, he looked at some people who had a degenerative disease, which mainly occurred in her left hemisphere and their artistic skills actually became enhanced and what was interesting, there hasn’t been a lot of research looking at the true geniuses, but one of the interesting stories about Einstein’s brain, it turns out that Einstein said it would be okay if they took his brain out and they examined it. And he was in Princeton, New Jersey, and there was a pathologist whose name was Thomas Harvey. So Harvey took the brain out and after it was fixated, he took a knife and he cut it into small blocks, 240 little blocks, and sent it all around the world to different people. And he said, well, tell me why he was a genius. People said, wait a minute, you gave me this little block of brain, how can I do anything? Well, the only thing that Harvey did was good was he actually photographed Einstein’s brain after he took it out. And what was really interesting is that on the left hemisphere, there’s a big, big, Valley called Sylvian fissure . It’s a big Fissure and it separates the frontal lobe from the temporal lobe and the parietal lobe from the temporal lobe. And what was really interesting about Einstein’s brain is that his Sylvian fissure can go all the way back and it didn’t actually go into the prior lobe . On the left side, it stopped really, really early. And after seeing that people said, oh, that’s why he was a genius because he didn’t have these big a soul . So I go into his prior lobe and dividing up his neural networks. Well, it turns out that one of the things we know about evolution is that the more GRI and salsa you have, it means the more cortex you have, okay. And that’s not a sign of superiority, it’s a sign that something is wrong. And if you look at his history, that part of the brain is very important for language I’m his parents for them to the pediatrician when he was about three years old, because he was not talking. And the other thing that was really interesting about Einstein’s brain, if you look at it, is that his right pro lobe was huge. Now, in addition, Arnstein was also probably dyslexic again, that parietal lobes’ important. So the question comes up that his less evolved left temporal low , allow his right to actually be superior. And it turns out when you read all the Weinstein’s works about himself, he said he always used spatial reasoning. And could it be that he was such a genius because again, his left hemisphere did not develop, but his right hemisphere really alone . Now, what’s really important. Also, as we’re going to talk about the frontal lobes are very important for divergent thinking. And it turns out, as I mentioned, Einstein had a huge, huge right frontal lobe. Richard Miles: 14:20 Ken, when we talk about divergent and convergent thinking for listeners who aren’t exactly sure what we mean by that, convergent thinking is when there’s one or a couple of right answers and you’re honing in on that right answer to a given problem and divergent thinking is when there could be a range of different types of solutions to a problem. One sort of looking in the other one sorta looking out. Dr. Kenneth Heilman: 14:41 Let me talk a little bit about that because the very first step in innovation to creative process is disengagement. What do I mean by disengagement? You have say, hey, this doesn’t explain your work, this is not the truth. And maybe one of the best examples of this is Copernicus who said , hey, wait a minute, this doesn’t make sense that will all revolving around the earth. Okay, It has to be other possibilities. Could it be that we’re revolving around Mars? or the sun? And then after he disengaged from that, he went ahead and used divergent thinking other possibilities, and he came up with a concept, hey, it’s the sun. We’re revolving around the sun. So the first step in creativity is first of all, disengagement, I don’t believe that’s the way done. Maybe as a better explanation. No one’s ever painted this one. No one’s ever written music. Hey, here’s a good novel no one’s ever written about. So you disengage from what has been done and then from there, you do divergent thinking saying, hey, what are the alternatives? What are the possibilities? Now it turns out from the neurological perspective, one of my mentors, Derek Denny Brown, brain neurologist said that all animals can do two things. They can approach or they can avoid and he said, this is even true of humans. He said it turns out that the frontal lobes are the disengage void organ and the temporal and parietal lobes and several or more for approach. And we know that when people damage their frontal lobes , what they do is they separate. In other words, they can’t disengage. So if we give them a test where they have to organize cards in a certain way called the Wisconsin card sorting , once they get one successful one, that’s it they’ll keep on repeating it, repeating it, repeating it, something we call the separation. And one of the things that we use to look at divergent thinking is something we call the alternative uses test. What you say to the person, okay, I’m going to give you an object and what I want you to do is give me the different things that you can do with this object. But the more different it is, the more points you get. So for example, I give somebody a word, the brick, if they say, Oh, you use it to build houses, to build fireplaces, you get maybe a point for each of those. If you say, Oh, you know, you’ve been using it as a doorstop or a bookend you get two points. If you say, Oh, you know, what you can do is take it in the bathtub with you and after your bath, you can use it to rub off your calluses you get three points. So your idea is that’s a test of divergent thinking, but creativity. So a lot of tests of creativity are one that’s used a lot is called a Torrance test. Where they have both verbal and visual-spatial test of divergent thinking. But as I said, this is only the first sub-stage of innovation. Now, a very important thing about innovation and creativity is curiosity and risk-taking. And that’s very, very, very important. And the reason why so many people get into creative occupations is because to them, it’s very rewarding. So you go back and you go through history and you look at artists , composers, whenever even scientists and what happened was financially, they did terribly, but they wanted to create because it gave them great joy. And the best example is Galileo, who proved Copernicus thing. You know, what the Pope did to him? Prisoner the rest of his life. Richard Miles: 18:36 Yeah. Dr. Kenneth Heilman: 18:36 And it turns out they finally forgave him about 40 years ago because he showed that the sun was in the center of the universe. Now it turns out that there’s a place deep in brain called the ventral striatum. And in animals, if you stimulate that, the animal will keep on doing whatever it was doing. It’s very rewarding. And that whole system is reward system. And it’s also hooked up to the frontal lobe. And it turns out that excitability of that system is very important for the drive and motivation. It turns out that, that system was also abnormal in people who use drugs. And that’s why actually, you see your very high rate of drug abuse in people who do creative. So let me go to the third part of innovation. So we have to disengage and say, hey, it has to be better answer to divergent thinking in saying , hey, what is the possibilities create ? The next one, and the critical element is finding the thread that unites and William James was really one of the founders of current psychology and said the thread that unites unheard of, combinations of elements and subtle associations and spearmint, another famous person who said creative ideas result from the combination of ideas that have been previously isolated. And perhaps the best example is Einstein’s E equals MC squared. Prior to that time, they were isolated. So it’s very important in the creative mode that the neurons in the brain and these modules that we’re talking about, that they communicate with each other. And there’s some evidence that that’s true. So one of the great experiments showing about this communication was done by a neurosurgeon, Joe Bogan. And we talked about that the right hemisphere is important for visual-spatial and the left for verbal and we had an epileptic’s whose seizures can be controlled, so they spread from one hemisphere to the other. So they were going to cut the connection between the two hemispheres, the corpus callosum. So the seizures couldn’t go from one side to the other side, but Bogan was curious whether or not this would interfere with creativity. So they gave people the inkblot test and the inkblot tests , as you know, just has inkblots and you tell people, hey, what does this look like? And then you could judge the creativity. People like me say that looks like a moth that looks like a bat and a lot of people come up with very creative ideas. So he tested these people and then after the collosum was cut, they retested them. And the creativity was actually gone. Why? Because the visual system could not communicate with the verbal system makes sense? Richard Miles: 21:31 These various parts of the brain have to be constantly swapping information with each other. Dr. Kenneth Heilman: 21:35 And in fact, when you record from the brain, the brain waves, when people are in a creative mode, their brainwaves actually go ahead and have a certain type of coherence, like they’re all communicating with each other. So in general, one of the things we ask is how do we increase our networks? Well, one of the great stories about chemistry is about tequila. They knew benzene had six carbons, but they didn’t know how it was organized. So he was drowsy and off to sleep. When you imagine or dream about a snake, biting its own tail in gear , Hey, it’s a ring, but it turns out if you look at almost all great creative ideas, people were almost always in a state of relaxation. Isaac Newton, when he came up with calculus and he came up with the laws of gravity, there was an epidemic almost like ours , but I think it was a little bit worse and they closed up Cambridge university. It was a plague, and so, he went up to his mother’s farm and now we have plenty of time and he sat under the apple tree and thought about these problems and came up with these ideas. When he went back to Cambridge, after it was over, they gave all kinds of administrative jobs because she was so successful with the ideas, he didn’t come up with much after that. Einstein came up with most of his theories late at night, in the patent office, when it was very, very quiet. Even when you think about when you get a great idea, you yell Eureka! Well, it was Archimedes who came up with that idea, the concept of buoyancy and what was he doing? He was taking a bath, another relaxing thing. The person who actually improves the nerves theory of the brain was a spanish physician, Raymond Ecohall, and he wrote a book actually, about creativity, which is an interesting book. In the book he says, if a solution fails to appear yet, we feel success is around the corner, just try resting for awhile . Now, another thing that we know about creativity is actually that one of the most creative types of people are people who have depression and bipolar disorder tend to be very, very creative. And so we thought what’s going on here about sleep, relaxation, depression, all those kinds of things. Well, it turns out they’re all similar in that in our brain, we have a neurotransmitter called norepinephrine. And when you get norepinephrine what happens is your attention goes externally rather than internally. So for example, if you were a child and you were sitting in the back of your class, just dreaming, daydreaming all the time the teacher you would say, hey, take your son or daughter to the doctor and get em some medicine. They give medicines like Dexedrine. They increase no norepinephrine. What do people do then? They attend to the teacher, they don’t go into their own mind . If you’re going to be creative, guess what you have to do. What do depressant people do almost all day long? Go into their own mind . So we actually wanted to test that theory. I did this with a fellow David B. We gave normal participants, anagram tests . You take words and you mix up the letters and you see how long it takes them to get the word. And some of them, we gave a medication called Propranolol, it blocks norepinephrine . One of the bad side effects, it turns out, if people take it too long, is depression. And it turns out when we gave these people Propranolol, this beta blocker of norepinephrine, guess what? They performed much better. Then with another fellow George Gotcebing. We know that when we treated epileptics, we found that one of the ways of doing it is by simulating one of the cranial nerves called the Vegas nerve. And what the Vegas nerve does is actually increase the output of norepinephrine in the brain. And it’s interesting because now they also use it to treat depression and we gave creativity tests while we’re stimulating. And we weren’t stimulating and low and behold, what do we find out? That when we are stimulating him your creativity went down. So in general, it’s important to go ahead and be in a very relaxed state. Richard Miles: 26:07 It sounds like in general, there’s this obviously complex interplay between left and right hemisphere and various areas of the brain. But if I had to sum it up, it seems to me in your book, a part of what you do is say that these various conditions in left hemisphere, whether they’re through an accident of birth, or an injury, or a certain mental state, we’re in the inclination to search for that conversion type of thinking and free up, the more divergent type of thinking that may occur elsewhere in the brain. Who , for instance, like I’d signed that the example you gave of him being delayed in his speaking clearly didn’t make him not a creative person. It may been just the opposite. Dr. Kenneth Heilman: 26:44 This is important that when people get head injuries, the place that they injure most likely is the, frontal lobes and the connections. And the frontal lobes are the critical thing, both for divergent thinking and for motivation to continue working and to actually produce the creative object or thought or whatever it might be. So, no , that’s not generally true. There have been cases where people did get injured. Strokes, dementia that didn’t enhance the creativity, but remember in those people, they paid a price, they were disabled. So yes, in certain unusual cases, brain damage can enhance it. But in most people interferes with every stage, the first stage, the preparation it interferes with that, it interferes with divergent thinking and it also interferes with convergent thinking. Richard Miles: 27:36 Ken, if we could come back to the question earlier, how much of this is hardwired? And you’re basically born with this ability to do that creative type of thinking at a high level and how much of it could be taught in schools or taught in workplaces and people could sort of make themselves be more creative in general? Dr. Kenneth Heilman: 27:53 No, you’re asking a very, very important question that’s going on for centuries and centuries. In general, both are important. Nature is important. Brain development is important and nurture is important. And those two things have to go together. So for example, there’s the famous story in Romania. The leader during communist times wanted to increase the population. So we encouraged people to have more and more children and they couldn’t afford the children, so they put them into these units. They fed them, but they didn’t play with them, and they didn’t hug them. Guess what’s happened to these kids. They were all mentally impaired because they need that stimulation to have the brain growth. And this is true throughout life. So it’s not purely nature because nurture helps develop the brain. And that’s been shown, you need a combination of both, but I think it is very, very important growing up to be a stimulator as possible and to do as many new and novel things that possibly you can. One of the things that really troubles me about our educational system is that in general, they downplay the opportunity for children to be creative. So who are the first teachers they fire when you have economic problems? Richard Miles: 29:12 The music teacher and those folks, right? Dr. Kenneth Heilman: 29:14 The music teacher and the art teacher, And in general, how do they gauge how well somebody does, they gauge it by their knowledge. There’s no tests that they give em that really looks at their creativity. And none of the teachers in school talk about even how do we enhance this creativity? And it’s really a shame because it turns out there was a book written by Richard Florida, and in his book, he says something very, very, important which is coming to be true in the future. The success of different nations, societies is not going to be based on people’s labor, like labor in factories, and so forth. It’s going to be primarily based on creativity. America has been very, very fortunate because it was a country of immigration. And the people who came here said, Hey, wait, I don’t like what things are going on here, there must be a better way. And therefore, America has been a very creative country. My grandmother, who was a Jewish grew up in Belarus, was pregnant with my mother and she told her husband, I don’t want to bring my kids up here. It can be spiteful and treated badly, I want to go to America. And it turns out that America allows people to become very creative. But we need to really force that in our school systems and we’re not doing it. And we’re doing everything the opposite way. So for example, in medicine now, how did they decide how valuable you are? By how many relative value units. So I’ll just tell you the story about me very briefly. I see patients with cognitive disorders and usually, in my afternoon clinic, I would see about four patients, but I was teaching medical students. And most of these patients were sent by other neurologists because they couldn’t figure out what was going on with these patients. And if you go into pub med and type my name, you’ll see how many reports there are about unusual patients. I got a letter from an administrator at The University of Florida that said, you come to clinic at 12:30, you don’t leave clinic until past six o’clock, and you’ll only see four new patients. It wasn’t really his fault, that is the mentality now. So even medicine, if you see something interesting, something that’s different that you want to really look at and examine you can’t do it. So, and so many domains were interfering in the schools and medical schools were interfering with really the growth of creativity. Which takes time, rest and patience. Richard Miles: 31:56 We’ll Ken, thank you very much. We’re about out of time, but that’s been a fascinating discussion about the relationship of creativity and the brain. And I’m thankful that somebody invented the internet and zoom and laptops, those creative folks made this conversation possible. So thank you to that wider community who makes these conversations as possible, but thank you very much for joining us today on Radio Cade. Dr. Kenneth Heilman: 32:17 Thank you for inviting me and for all the wonderful work you all are doing in enhancing creativity to Bob Cade is so wonderful. Finding out about the museum is something that’s looking at attempting to enhance creativity. Thank you so much. Richard Miles: 32:32 Well, thanks for coming on Ken, appreciate it. Outro: 32:34 Radio Cade is produced by the Cade museum for Creativity and Invention in Gainesville, Florida . Richard Miles is the podcast host and Ellie Thom coordinates, inventor interviews. Podcasts are recorded at Hardwood Soundstage, and edited and mixed by Bob McPeak . The Radio Cade theme song is produced and performed by Tracy Collins and features violinist, Jacob Lawson.

Michelle's Questions: I am 52 years old going through menopause since 48. I had a hysterectomy at age of 36 and kept my ovaries for the hormones. My ovaries are nonfunctional now. I was on Premarin, but when I sought out a specialist for hormone therapy, I was prescribed: Estradiol 0.5 Estriol one milligram, which is technically Bios. It's the combination of estriol and Estradiol. Estradiol was 0.5 milligrams, Estriol is one milligram. And I am also taking a hundred milligrams of Progesterone. I take this at night. I've had a weight gain of 40 lbs and suffer from anxiety at night since starting menopause. I was prescribed Propranolol, which is technically a blood pressure medication, but it does help with reducing anxiety. But she has prescribed the propranolol for this and it seems to take the edge off. I have poor sleep as well, where I used to sleep very well. What am I missing? Am I on the right track? I feel deconditioned fatigue and brain fog to mention a few. I feel poorly when I used to be a happy, healthy person. Please help with recommendations. Would testosterone help? My levels were not terrible enough to prescribe. Answer:  In this episode, we discuss a question we received from Michelle that was started on Premarin but then transitioned to 1.5 mg of Biest cream. Of course, we are not fans of Premarin and would never prescribe this for our patients. However, we do prescribe Biest all of the time. There is very little similarity between Premarin and Biest. When transitioning from a tablet form of estrogen like Premarin to a transdermal cream, the dosing of the Biest needs to be definitely increased. For most women, our starting Biest dose is typically 3 mg to 5 mg. Full Transcript PYHP 073  Download Transcription PYHP 073  Dr. Maki: Hello everyone. Thank you for joining us for another episode of the progression health podcast. I'm Dr. Maki. Dr. Davidson: And I'm Dr. Davidson. Dr. Maki: So just as a warning before we get jumping into the episode, we are in our home office recording this. Our dog is with us as well. He's always with us. We can't really go anywhere without him, but he's laying on the floor with a bone. So, if you hear any strange noises or any banging around, he's just either repositioning or trying to find another bone. We can't really go anywhere without him. And he's happy as long as we're close by. Dr. Davidson: In some ways. He's kind of our first dog, 'cause our other one was a poodle, which they always say once you have a poodle, all the other ones are just dogs. So, he was completely different from this one. He follows us everywhere so if you hear him chewing, he's chewing on a bone. Thank goodness he doesn't chew on other things. It's just his bones. Dr. Maki: No shoes, no clothes, no furniture. Just bones. So, we're good, we're lucky about that. All right, so, now this episode and the next few, we know enough to

The betablocker Propranolol or Inderal was the First drug approved by the FDA in 1974 for Migraine Prevention.

If there’s a pill that makes people less racist, should cops be forced to take it?

This week in the NB Hot Topics podcast Dr Near Tucker looks at the latest news including propranolol overdose and assisted dying, examines the latest research from around the world on Covid-19 and from the UK on CKD screening, then explores the murky world of big data and computer-assisted medicine and how this will affect us in general practice.

Emma was a 24-year-old pharmacy graduate. She had two degrees, was a high achiever and was making the most of her life. Sadly Emma took an overdose of both propranolol and citalopram. Emma called an ambulance, but her condition quickly worsened. Despite resuscitation efforts from both paramedics and medical staff in the hospital she was transferred to, Emma sadly died. The purpose of this podcast was to highlight the findings of the report written as a result of the investigation undertaken by the Healthcare Safety Investigation Branch (HSIB). We were fortunate to be joined by Deinniol Owens a National Investigator at the HSIB. Deinniol and I had a chat about the aspects of the investigation that are pertinent to pharmacists. The report makes a number of recommendations but also emphasises that there is a link between anxiety, depression and migraine and that more research is needed to understand the interactions between antidepressants and propranolol in overdose. The safety recommendations focused on the following: Updating clinical guidance (NICE) and the UK’s pharmaceutical reference source (the British National Formulary) on use of propranolol and highlighting the toxicity in overdose. National organisations supporting their staff members to understand the risks when prescribing propranolol to certain patients. Improving the clinical oversight in ambulance control rooms and the treatment/transfer guidance for ambulance staff for propranolol/beta-blocker overdose.

DOGMADoğruluğu deneyden geçirilmeden, sınanmadan kabul edilen, olduğu gibi benimsenen ve bir öğretinin ya da ülkünün dayanağı yapılan sav. Size ertesi gün sınavı olduğu için uyanık kalmak adına beş kutu enerji içeceği içtikten sonra acil servise çarpıntı şikayeti ile başvuran bir hastadan bahsetsem. Hastamızın nabzı 156 atım/dk ve kan basıncı normal olsun. Bu hastada kalp hızını nasıl normale döndürürsünüz? Benzodiazepinlerle mi? Ama çocuğun yarın sınavı var ve uyuklamak istemiyor. Peki metaprolol vermeye ne dersiniz? Hayatta olmaz mı? Kontraendike !? Neden? Çünkü karşılanmamış alfa stimülasyonu diye bir şey var. Peki var mı gerçekten? Ya bu bilgi bir dogmaysa… Gelin bu konuyu birlikte tartışalım​1​ .  “Karşılanmamış alfa stimülasyonu” – Ne ola ki? Karşılanmamış alfa stimülasyonu basit bir tabirle beta-blokör alımı sonrası kan basıncında hızlı yükselme ve / veya koroner arter vazokonstrüksiyonunda kötüleşme olarak tanımlanır. Aslında fizyolojik mekanizma kâğıt üzerinde bakıldığında anlamlı gelebilir. Adrenerjik sistemde alfa-1 reseptörlerinin uyarılması düz kaslarda kasılma ve vazokonstrüksiyona neden olur. Beta-1 reseptörleri uyarıldığında kalbin hızı, iletimi ve kasılması artar; beta-2 reseptörler uyarıldığında ise düz kaslar gevşer. Alfa-1 ve beta-2 uyarım arasındaki denge vasküler tonusu düzenler. Propranolol gibi nonselektif bir beta bloker kullanılırsa bu denge alfa-1 lehine bozulur ve vazokonstrüksiyon beklenir. Başka bir açıklama da, beta-1 blokajı sonucu kalp hızı azalır ve diastol sonu basıncı ve kardiyak fiber boyu artar; bu da Frank-Starling Kanunu’na göre ventriküler kontraksiyona ve kan basıncında artışa neden olur.    Kalbin aşırı katekolaminle uyarımı taşikardi ve myokardiyal kontraktilitede artma yapar ki bu iki durum oksijen ihtiyacının önemli belirleyicileridir. Bu durum nihayetinde hücre içi kalsiyum yükü aşırı artmasına ve myosit hasarı ve enfarktüs gelişmesine sebep olacaktır. Konjestif kalp yetmezliği, tirotoksikoz, feokromasitoma, intrakraniyel kanama, travma, sepsis gibi aşırı endojen katekolamin uyarımının olduğu birçok durumda beta-blokerlerin fayda sağladığı gösterilmiştir. Bu gibi hiperadrenerjik durumlar ile acil servislerde defalarca kez karşılaşılmış olmasına ve milyonlarca doz beta-bloker verilmiş olmasına rağmen neden “karşılanmamış alfa stimülasyonu” denen durumla karşılaşılmamıştır? Çoğu hekime göre bu dogma biraz fazla abartılmaktadır; ancak yine çoğu hekim ders kitaplarında böyle vurgulandığından bu dogmayı kabul etmektedir. Bu dogma nasıl bu kadar yerleşti? Her şey 1985’te başladı. Ramoska​2​ “karşılanmamış alfa stimülasyonu ”nu kokain zehirlenmesi ile başvuran ajite bir hastada tanımladı.  Propranolol aldıktan sonra hastanın kan basıncı 170/118’den 180/140’a yükselmiş, kalp hızı da 112 atım/dk’dan 104’e gerilemişti. Hastaya ne mi oldu? Olumsuz bir şey olmadı, hasta sakinleşti ve önerilenin aksine acil servisi izinsiz terk etti. Daha sonra 1990’da Lange​3​ uyarıcı toksisitesinde beta bloker kullanımına karşı çıkanların köşe taşı olan, kokain alımında propranalol kullanımı ile ilgili ilk prospektif çalışmayı yayınladı. İlginç olan, eleştirmenlerin çok azı çalışmanın ayrıntılarına vakıftı. Bu çalışma da kardiyak kateterizasyon sırasında nazal kokain kullandırılan 10 gönüllüye, kokain sonrası direkt olarak koroner arterlere propranolol enjekte edilmiş; vakaların yarısında kokain sonrası ortaya çıkan koroner vasokonstruksiyonunun propranololdan sonra %10’dan daha fazla oranda artış gösterdiği ve bir vakada da tam koroner arter oklüzyonuna bağlı STEMI geliştiği gözlenmişti. Bu çalışmadan sonra “karşılanmamış alfa stimülasyonu” fenomeni ve beta bloker kontraendikasyonu ders kitaplarında yer almaya başladı. Oysa ki intrakardiyak propranolol, onu bırakın IV propranololün acil serviste kullanım yeri neydi? Bir daha hiçbir zaman tekrarlan(a)mayacak bu çalışma bir dogmanın temellerini atmış oldu. Bu konudaki çalışmaların tamamı bir elin parmaklarını geçmez.

In this episode I cover benign essential tremor.If you want to follow along with written notes on benign essential tremor go to https://zerotofinals.com/medicine/neurology/essentialtremor/ or the neurology section in the Zero to Finals medicine book.This episode covers presentation, diagnosis and management of benign essential tremor. The audio in the episode was expertly edited by Harry Watchman.

กินยาอยู่ทุกวันตามเวลา การนอน การตื่น ที่ค่อนข้างเป็น Routine (ถึงจะเวลาต่างจากชาวบ้านก็เถอะ) แต่ทีนี้ก็ไม่แน่ใจว่าตอนไปอังกฤษที่เวลาต่างกัน 6 ชั่วโมง เวลานอนกับตื่น เหมือนจะสลับๆกัน แล้วบนเครื่องอีก เวลามันก็จะงงๆ แล้วเราควรจะกินยายังไงดี.. ลองฟังกันดูนะ ว่ากรณีไหน ควรกินยายังไงบ้าง

Propranolol could provide cognitive and social benefits in autism - University of Missouri-Columbia

Even short-term oral steroids have risks - Propranolol safe for hemangiomas - Exercise-induced purpura is a thing - Higher BMI -> greater risk for psoriatic arthritis - Lots of things can cause EM - BWH vs AJCC8: Does B-dubs win? You make the call!

Connor and Jack explore the poem “Medical History” by Nicole Sealey. They consider medical histories as a form, think through the link between racism and black health disparities, try to figure out what makes the ending so startling and incredible, and meander embarrassingly into the world of sportsball. Read the poem below. Check out her debut collection here: https://www.harpercollins.com/9780062688828/ordinary-beast/ More about Nicole Sealey, here: http://nicolesealey.com/ Find us on Facebook at: facebook.com/closetalking 
Find us on Twitter at: twitter.com/closetalking
 You can always send us an e-mail with thoughts on this or any of our previous podcasts, as well as suggestions for future shows, at closetalkingpoetry@gmail.com. Medical History By: Nicole Sealey I’ve been pregnant. I’ve had sex with a man who’s had sex with men. I can’t sleep. My mother has, my mother’s mother had, asthma. My father had a stroke. My father’s mother has high blood pressure. Both grandfathers died from diabetes. I drink. I don’t smoke. Xanax for flying. Propranolol for anxiety. My eyes are bad. I’m spooked by wind. Cousin Lilly died from an aneurysm. Aunt Hilda, a heart attack. Uncle Ken, wise as he was, was hit by a car as if to disprove whatever theory toward which I write. And, I understand, the stars in the sky are already dead.

Nate Hale is one of the world's top orchestral bassoonists.  We originally met during my podcast with director Marc Webb as he was in town auditioning for the Los Angeles Philharmonic.  We caught up recently to talk about the incredibly high stress audition process for the top symphony orchestras, the widespread use of Beta-Blockers by orchestral musicians, his path to being one of the world's top bassoonist, and his love of telling stories within a symphony orchestra.  Jeff Grace (Host) @jeffgrace (Twitter) @jeffgrace (Instagram) Nate Hale (Guest) Nate Hale (Linkedin) Mentioned in this Episode Indianapolis Symphony Orchestra Los Angeles Philharmonic Beta Blockers (propranolol) Music by Michael Sempert WestChannel.com | Michael Sempert on Spotify

man skal præstere noget – hvad enten det gælder en vigtig eksamen eller en vigtig præsentation på arbejde. Men for nogen udvikler sommerfuglene i maven sig angstpræget adfærd hvilket for en del betyder at de må tage medicin for at komme igennem f.eks. eksamensperioder. Denne gang handler Ugeskriftets videnskabelige podcast om Propranolol. For er det ok at give medicin til patienter der ellers ikke fejler noget, og er det en slags hjernedoping hvis man op til en eksamen bruger hvad nogen steder betragter som præstationsfremmende midler? Tilrettelagt og klippet af Karen Sigrid Jacobsen, medvirkende Søren Bøgevig, overlæge ved klinisk farmakologisk afdeling på Bispebjerg Hospital i København.

Vous vous rendez compte que dans un petit peu plus d'un mois nous seront obligés d'animer cette émission sans pouvoir bénéficier de l'anonymat du web ? Pire encore, on sera contraint de montrer notre corps à une petite centaine de gens. On sera là, 6 ou 7, alignés comme en 40, à attendre quelques réactions qu'on va, tant bien que mal, essayer d'orienter en notre faveur. Et ce de façon totalement gratuite. On sera sûrement drogués, endormis par quelques substances illicites, des potions alcoolisées. On sera usés, cassés, sur les rotules et sans béquilles après deux jours de torture intense. Voici donc le dernier CVT avant de retrouver le public de PodRennes ! Au programme : les actualités du mois passé, quelques jeux, un roman-photos, de la culture, et une discussion sur l'intégration avec Mélanie du podcast Melting Pot et Cristina de Expat Heroes. Les liens des invitées : https://www.meltingpotlepodcast.com/ http://www.expat-heroes.com/ https://www.liberation.fr/planete/2019/03/01/vonhier-un-hashtag-ou-debattre-de-l-obsession-des-allemands-pour-les-origines_1712171 Le roman-photos : https://imgur.com/a/0hnLDF3 Les liens de l'émission : https://www.valeursactuelles.com/societe/le-new-york-times-reproche-au-film-mary-poppins-detre-raciste-103612 https://actu.orange.fr/france/video-le-propranolol-le-remede-contre-les-ruptures-amoureuses-magic-CNT000001cVlAM.html https://www.sciencesetavenir.fr/espace/systeme-solaire/exomars-le-rover-s-appellera-rosalind-franklin_131356 https://fr.wikipedia.org/wiki/Med_Hondo https://www.ledauphine.com/france-monde/2019/02/10/dans-les-cours-de-recre-la-gardav-consiste-a-tabasser-un-eleve https://www.20minutes.fr/arts-stars/culture/2443391-20190204-ministere-education-retire-ecoles-manga-jiro-taniguchi-juge-inapproprie https://france3-regions.francetvinfo.fr/hauts-de-france/belgique-char-caricaturant-juifs-fait-polemique-au-carnaval-alost-1634150.html https://parismatch.be/actualites/societe/245768/au-carnaval-dalost-des-deguisements-du-ku-klux-klan-ne-passent-pas https://www.huffingtonpost.fr/2019/02/28/avant-les-europeennes-captain-europe-fait-son-grand-retour-et-fait-bien-rire_a_23680276/ https://www.bfmtv.com/tech/ce-site-web-genere-des-photos-de-gens-qui-n-existent-pas-1632388.html https://www.europeanscientist.com/fr/agriculture-fr/tudder-lapplication-de-rencontres-pour-les-bovins/ https://www.demotivateur.fr/article/pour-la-saint-valentin-donne-le-nom-de-ton-ex-a-un-cafard-15493 http://www.leparisien.fr/societe/un-zoo-anglais-propose-aux-visiteurs-de-jouer-au-tir-a-la-corde-avec-un-lion-22-02-2019-8018661.php https://www.ladepeche.fr/2019/02/10/des-gilets-jaunes-confondent-un-journaliste-basque-avec-francois-berleand-et-linonde-dinsultes-sur-twitter,8006666.php https://www.20minutes.fr/arts-stars/television/2464867-20190304-disparition-luke-perry-inoubliable-dylan-beverly-hills-decede-apres-avc https://fr.wikipedia.org/wiki/Buffy,_tueuse_de_vampires

The post Propranolol (Inderal) Nursing Pharmacology Considerations appeared first on NURSING.com.

Let’s start episode 312 of Secrets of Organ Playing Podcast. Today I’d like to share with you the discussion that was going on our communication channel on BaseCamp between Total Organist students. Annabelle wrote the answer to the question “What is she currently working on?” and “What is she struggling with?” So she is playing Wedding March by Wagner and she writes: Annabel: I'm playing for a wedding in October and have some issues with performance anxiety. So I thought it would help to learn it by heart. David: Great idea I have the anxiety issues, too. 2 bananas 30 minutes before performance has been helping me keep my hands and ankles from shaking so badly and slows down my racing heart. Recently my doctor suggested trying a medication called Propranolol, so this Sunday will be the first run with it. I don't always need that kind of help, but when my performance anxiety gets out of control, I need just a little help. Annabel: I’ll try bananas, that's very interesting. Is it the potassium? I'm fine accompanying hymns, I just don't like being a soloist! David: Potassium for the heart rate, but allegedly they have a natural beta blocker in them to help with shaking hands and ankles. It's folk lore, but there seem to be a while lot of even professional musicians who swear by it. I opted for Propranolol because I can't have too much potassium. Annabel: Fascinating, thanks David. I've started reading quite an old book called "Tensions in the Performance of Music" edited by Carola Grindea. It was recommended to me by a professional harpist. David: Thank you! I will look for that Vidas: I once ate bananas and drank mineral water entire concert day. When my turn came up to play, I felt as light as an angel.

In addition to the three main classes of anti-hypertensives we already discussed, ACE Inhibitors like Lisinopril and Captopril, Beta Blockers like Metoprolol and Propranolol, and Calcium Channel Blockers like Nicardipine and Diltiazem, there are a number of other classes of… The post Cardiac Labs and Meds for Nurses appeared first on NURSING.com.

Commentary by Dr. Valentin Fuster

Dr Pantziarka speaks with ecancertv at ESMO 2016 about current efforts, and regulatory hurdles, towards the repurposing of medicines that are approved to treat other diseases, but have the potential to improve cancer patient outcomes. He discusses how propranolol, a beta-blocker commonly prescribed to treat hypertension, might be a cheap and effective adjuvant in cancer therapy. Dr Pantziarka is also joined by Dr Lydie Meheus of The Anticancer Fund, Belgium.

Rowena Fletcher-Wood discovers how to stave off stage fright, with a simple compound that revolutionised drug development

Pathophysiology behind specific medication treatment of a beta-blocker overdose.

In 2012, an interdisciplinary team of scientists at the University of Oxford reported that, based on their clinical experiment, the beta-blocker drug, Propranolol, could reduce implicit racial bias among its users. Whites were given a single oral dose of the drug, then asked to complete the Implicit Association Test, a reliable measure of racial prejudice. Relative to the placebo, those who were given Propranolol experienced no indicators of implicit racial bias. Though the researchers warned of the danger in biological research being used to make a “more moral society,” they also asserted “such research raises the tantalizing possibility that our unconscious racial attitudes could be modulated using drugs.” Shortly after the experiment, an article in Time Magazine, citing the study, asked the question that frames our project: Is racism becoming a mental illness? My new book project traces the genealogies of race and racism as psychopathological categories from mid-19th century Europe and the United States up to the aforementioned clinical experiment at the University of Oxford. Using historical, archival, and content analysis, we provide a rich account for how the 19th century ‘Sciences of Man’, including anthropology, medicine, and biology, used race as a means of defining psychopathology at the very beginning of modern clinical psychiatry and subsequently how these claims about race and madness became embedded within claims of those disciplines that deal with mental health and illness. Finally, we describe the contemporary shift in explaining racism occurring since the end of World War II – from that of a social, political, and cultural consequence to that of a pathological byproduct.

Dr. Elliot Israel interviews Dr. Brian J. Lipworth

Dr. Juan G. Abraldes discusses his manuscript "Patients Whose First Episode of Bleeding Occurs While Taking a β-Blocker Have High Long-term Risks of Rebleeding and Death." To view the print version of this abstract go to http://bit.ly/KXtG7o.

Dr. Juan G. Abraldes discusses his manuscript "Patients Whose First Episode of Bleeding Occurs While Taking a β-Blocker Have High Long-term Risks of Rebleeding and Death." To view the print version of this abstract go to http://bit.ly/KXtG7o.

Can racism be treated with heart drugs? A recent study suggests so. Does this mean that we can alter a person's moral values with drugs? And what other possibilities are there for engineering the human condition? We ask Julian Savulescu.