Podcasts about metazoa

The Craft Brewers Conference kicks off in Indianapolis next week. If you're headed to the circle city, you're likely looking for bar, restaurant, and entertainment options. You're in luck This week it's a roundtable episode with three Hoosiers that know all the best spots.  Even if you're not going to the conference, the city is still one you should visit for beer.For more Drink Beer, Think Beer check out All About Beer.SponsorsStomp StickersStomp Stickers is a proud member of the Brewers Association that produces a wide variety of printed brewery products such as beerlabels, keg collars, coasters, beer boxes and much more. Stomp's website features an easy-to-use design tool, low quantity orders, fast turn times, and free domestic shipping. Visit StompStickers.com and use code THINKBEER for 15% off your first order.The 5th IngredientIf you're running a brewery owner or operator, Beer30 by The 5th Ingredient is the ultimate command center. The most powerful brewery management software on the market, Beer30 handles the entire brewing workflow, from recipe development to production. Once your beer is brewed and ready, it seamlessly manages your inventory and streamlines your brewery's sales and distribution--all in the same easy-to-use platform. Beer30 lets you get back to the beer and the people that made you fall in love with this industry in the first place. And no other brewery management software gives you the ability to truly master your business and get the insights that you need to thrive in an increasingly competitive industry. Visit the5thingredient.com/AllAboutBeer today to learn more and receive 3 free months of Beer30.Visit IndyYou love craft beer. You'll love Indy.The Indy Craft Pass is your free passport to 40+ of the city's best breweries — Sun King, Metazoa, Upland, and so many more. Check in, earn points, score swag — yes, beer can actually win you prizes! Sip local, explore new taprooms, and make your beer run count. Grab your free Indy Craft Pass now at VisitIndy.com — and let the good beers roll! Host: John HollGuests: Julia Whitson, Eddie Chimi, John Allison Sponsors: All About Beer, Stomp Stickers, The 5th Ingredient, Visit IndyTags: Brewing, Taproom, Restaurants, Hospitality, IndianaPhoto: John Holl

A conversation with Dave Colt, the co-founder, CEO, and Brewmaster of Sun King Brewery in Indianapolis. For more Drink Beer, Think Beer check out All About Beer.SponsorsStomp StickersStomp Stickers is a proud member of the Brewers Association that produces a wide variety of printed brewery products such as beerlabels, keg collars, coasters, beer boxes and much more. Stomp's website features an easy-to-use design tool, low quantity orders, fast turn times, and free domestic shipping. Visit StompStickers.com and use code THINKBEER for 15% off your first order.The 5th IngredientIf you're running a brewery owner or operator, Beer30 by The 5th Ingredient is the ultimate command center. The most powerful brewery management software on the market, Beer30 handles the entire brewing workflow, from recipe development to production. Once your beer is brewed and ready, it seamlessly manages your inventory and streamlines your brewery's sales and distribution--all in the same easy-to-use platform. Beer30 lets you get back to the beer and the people that made you fall in love with this industry in the first place. And no other brewery management software gives you the ability to truly master your business and get the insights that you need to thrive in an increasingly competitive industry. Visit the5thingredient.com/AllAboutBeer today to learn more and receive 3 free months of Beer30.Visit IndyYou love craft beer. You'll love Indy.The Indy Craft Pass is your free passport to 40+ of the city's best breweries — Sun King, Metazoa, Upland, and so many more. Check in, earn points, score swag — yes, beer can actually win you prizes! Sip local, explore new taprooms, and make your beer run count. Grab your free Indy Craft Pass now at VisitIndy.com — and let the good beers roll! Host: John HollGuest: Dave ColtSponsors: All About Beer, Stomp Stickers, The 5th Ingredient, Visit IndyTags: Brewing, Taproom, Hospitality, IndianaPhoto: John Holl

We're back in Indianapolis this week for a conversation with the couple behind Kismetic Beer Company - Nicole and Ryan Oesch. It's a conversation on taproom aesthetics, beers that inspire, and community building. For more Drink Beer, Think Beer check out All About Beer.SponsorsStomp StickersStomp Stickers is a proud member of the Brewers Association that produces a wide variety of printed brewery products such as beerlabels, keg collars, coasters, beer boxes and much more. Stomp's website features an easy-to-use design tool, low quantity orders, fast turn times, and free domestic shipping. Visit StompStickers.com and use code THINKBEER for 15% off your first order.The 5th IngredientIf you're running a brewery owner or operator, Beer30 by The 5th Ingredient is the ultimate command center. The most powerful brewery management software on the market, Beer30 handles the entire brewing workflow, from recipe development to production. Once your beer is brewed and ready, it seamlessly manages your inventory and streamlines your brewery's sales and distribution--all in the same easy-to-use platform. Beer30 lets you get back to the beer and the people that made you fall in love with this industry in the first place. And no other brewery management software gives you the ability to truly master your business and get the insights that you need to thrive in an increasingly competitive industry. Visit the5thingredient.com/AllAboutBeer today to learn more and receive 3 free months of Beer30.Visit IndyYou love craft beer. You'll love Indy.The Indy Craft Pass is your free passport to 40+ of the city's best breweries — Sun King, Metazoa, Upland, and so many more. Check in, earn points, score swag — yes, beer can actually win you prizes! Sip local, explore new taprooms, and make your beer run count. Grab your free Indy Craft Pass now at VisitIndy.com — and let the good beers roll! Host: John HollGuests: Nicole Oesch, Ryan OeschSponsors: All About Beer, Stomp Stickers, The 5th Ingredient, Visit IndyTags: Brewing, Taproom, Hospitality, IndianaPhoto: John Holl

This week starts our road to Indianapolis and the upcoming Craft Brewers Conference. Indianapolis is a great city to visit and has a host of excellent breweries. One of them, Guggman Haus Brewing Co. joins the show to talk about about lagers, Indy Car racing, and building a family business. For more Drink Beer, Think Beer check out All About Beer.SponsorsStomp StickersStomp Stickers is a proud member of the Brewers Association that produces a wide variety of printed brewery products such as beerlabels, keg collars, coasters, beer boxes and much more. Stomp's website features an easy-to-use design tool, low quantity orders, fast turn times, and free domestic shipping. Visit StompStickers.com and use code THINKBEER for 15% off your first order.The 5th IngredientIf you're running a brewery owner or operator, Beer30 by The 5th Ingredient is the ultimate command center. The most powerful brewery management software on the market, Beer30 handles the entire brewing workflow, from recipe development to production. Once your beer is brewed and ready, it seamlessly manages your inventory and streamlines your brewery's sales and distribution--all in the same easy-to-use platform. Beer30 lets you get back to the beer and the people that made you fall in love with this industry in the first place. And no other brewery management software gives you the ability to truly master your business and get the insights that you need to thrive in an increasingly competitive industry. Visit the5thingredient.com/AllAboutBeer today to learn more and receive 3 free months of Beer30.Visit IndyYou love craft beer. You'll love Indy.The Indy Craft Pass is your free passport to 40+ of the city's best breweries — Sun King, Metazoa, Upland, and so many more. Check in, earn points, score swag — yes, beer can actually win you prizes! Sip local, explore new taprooms, and make your beer run count. Grab your free Indy Craft Pass now at VisitIndy.com — and let the good beers roll! Host: John HollGuests: Abby Gorman and Derek GuggenbergerSponsors: All About Beer, Stomp Stickers, The 5th Ingredient, Visit IndyTags: Lager, Hospitality, Indiana, RacingPhoto: John Holl

Peter Godfrey-Smith knows his cephalopods. Once of CUNY and now a professor of history and philosophy of science at University of Sydney, his truly capacious career includes books such as Theory and Reality (2003; 2nd edition in 2020), Darwinian Populations and Natural Selection (2009) and most recently Metazoa. RtB--including two Brandeis undergraduates as guest hosts, Izzy Dupré and Miriam Fisch--spoke with him back in October 2021 about his astonishing book on the fundamental alterity of octopus intelligence and experience of the world, Other Minds: The Octopus, the Sea and the Deep Origins of Consciousness. Another equally descriptive title for that book, and for the discussion we share with you here (after Thomas Nagel's "What is it like to be a Bat?") might be What is it Like to be an Octopus? As always, below you will find helpful links for the works referenced in the episode, and a transcript for those who prefer or require a print version of the conversation. Please visit us at Recallthisbook.org (or even subscribe there) if you are interested in helpful bonus items like related short original articles, reading lists, visual supplements and past episodes grouped into categories for easy browsing. Mentioned in the Episode: Adrian Tchaikovsky, Children of Ruin "Open the pod bay doors, Hal": a chilling line from 2001: A Space Odyssey (1968) District Nine (2009, dir. Neill Bloomkamp) in which giant intelligent shrimp from outer space play the role of octopus-like alien intelligence, and prompt a complex but unmistakably racist reaction on their arrival in South Africa. Charles Darwin, The Expression of the Emotions in Man and Animals (1872) Erik Linklater, Pirates in the Deep Green Sea (1949) Listen and Read Here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Peter Godfrey-Smith knows his cephalopods. Once of CUNY and now a professor of history and philosophy of science at University of Sydney, his truly capacious career includes books such as Theory and Reality (2003; 2nd edition in 2020), Darwinian Populations and Natural Selection (2009) and most recently Metazoa. RtB--including two Brandeis undergraduates as guest hosts, Izzy Dupré and Miriam Fisch--spoke with him back in October 2021 about his astonishing book on the fundamental alterity of octopus intelligence and experience of the world, Other Minds: The Octopus, the Sea and the Deep Origins of Consciousness. Another equally descriptive title for that book, and for the discussion we share with you here (after Thomas Nagel's "What is it like to be a Bat?") might be What is it Like to be an Octopus? As always, below you will find helpful links for the works referenced in the episode, and a transcript for those who prefer or require a print version of the conversation. Please visit us at Recallthisbook.org (or even subscribe there) if you are interested in helpful bonus items like related short original articles, reading lists, visual supplements and past episodes grouped into categories for easy browsing. Mentioned in the Episode: Adrian Tchaikovsky, Children of Ruin "Open the pod bay doors, Hal": a chilling line from 2001: A Space Odyssey (1968) District Nine (2009, dir. Neill Bloomkamp) in which giant intelligent shrimp from outer space play the role of octopus-like alien intelligence, and prompt a complex but unmistakably racist reaction on their arrival in South Africa. Charles Darwin, The Expression of the Emotions in Man and Animals (1872) Erik Linklater, Pirates in the Deep Green Sea (1949) Listen and Read Here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/environmental-studies

Peter Godfrey-Smith knows his cephalopods. Once of CUNY and now a professor of history and philosophy of science at University of Sydney, his truly capacious career includes books such as Theory and Reality (2003; 2nd edition in 2020), Darwinian Populations and Natural Selection (2009) and most recently Metazoa. RtB--including two Brandeis undergraduates as guest hosts, Izzy Dupré and Miriam Fisch--spoke with him back in October 2021 about his astonishing book on the fundamental alterity of octopus intelligence and experience of the world, Other Minds: The Octopus, the Sea and the Deep Origins of Consciousness. Another equally descriptive title for that book, and for the discussion we share with you here (after Thomas Nagel's "What is it like to be a Bat?") might be What is it Like to be an Octopus? As always, below you will find helpful links for the works referenced in the episode, and a transcript for those who prefer or require a print version of the conversation. Please visit us at Recallthisbook.org (or even subscribe there) if you are interested in helpful bonus items like related short original articles, reading lists, visual supplements and past episodes grouped into categories for easy browsing. Mentioned in the Episode: Adrian Tchaikovsky, Children of Ruin "Open the pod bay doors, Hal": a chilling line from 2001: A Space Odyssey (1968) District Nine (2009, dir. Neill Bloomkamp) in which giant intelligent shrimp from outer space play the role of octopus-like alien intelligence, and prompt a complex but unmistakably racist reaction on their arrival in South Africa. Charles Darwin, The Expression of the Emotions in Man and Animals (1872) Erik Linklater, Pirates in the Deep Green Sea (1949) Listen and Read Here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Peter Godfrey-Smith knows his cephalopods. Once of CUNY and now a professor of history and philosophy of science at University of Sydney, his truly capacious career includes books such as Theory and Reality (2003; 2nd edition in 2020), Darwinian Populations and Natural Selection (2009) and most recently Metazoa. RtB--including two Brandeis undergraduates as guest hosts, Izzy Dupré and Miriam Fisch--spoke with him back in October 2021 about his astonishing book on the fundamental alterity of octopus intelligence and experience of the world, Other Minds: The Octopus, the Sea and the Deep Origins of Consciousness. Another equally descriptive title for that book, and for the discussion we share with you here (after Thomas Nagel's "What is it like to be a Bat?") might be What is it Like to be an Octopus? As always, below you will find helpful links for the works referenced in the episode, and a transcript for those who prefer or require a print version of the conversation. Please visit us at Recallthisbook.org (or even subscribe there) if you are interested in helpful bonus items like related short original articles, reading lists, visual supplements and past episodes grouped into categories for easy browsing. Mentioned in the Episode: Adrian Tchaikovsky, Children of Ruin "Open the pod bay doors, Hal": a chilling line from 2001: A Space Odyssey (1968) District Nine (2009, dir. Neill Bloomkamp) in which giant intelligent shrimp from outer space play the role of octopus-like alien intelligence, and prompt a complex but unmistakably racist reaction on their arrival in South Africa. Charles Darwin, The Expression of the Emotions in Man and Animals (1872) Erik Linklater, Pirates in the Deep Green Sea (1949) Listen and Read Here. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/animal-studies

Traditional stories of the evolution of life on our planet tell us that we and all other creatures on Earth were shaped by evolution. But how do minds that are shaped by evolution go on to transform nature in their own right? In the final volume of the landmark trilogy that began with Other Minds and continued with Metazoa, philosopher of science Peter Godfrey-Smith explores the role that animal minds - and, especially, human minds - have had on our world. If you've ever wondered why it was primates and not dolphins who developed language and culture, whether or not medical testing on animals can be ethically justified, and which aspects of Gaia theory hold up today, this episode is for you. Learn more about your ad choices. Visit podcastchoices.com/adchoices

We may not know what it's like to be a bat, but we're pretty confident that it's like something—that bats (and other mammals) are sentient creatures. They feel pleasure and pain, cold and warmth, agitation and comfort. But when it comes to other creatures, the case is less clear. Is a crab sentient? What about a termite, or a tree? The honest answer is we just don't know—and yet, despite that uncertainty, practical questions arise. How should we treat these beings? What do we owe them? My guest today is Dr. Jonathan Birch. Jonathan is a Professor of Philosophy at the London School of Economics and the author of the new book The Edge of Sentience: Risk and Precaution in Humans, Other Animals, and AI. In it, he presents a framework for thinking about which beings might be sentient and about how our policies should account for this. Here, we talk about Jonathan's work at the nexus of philosophy, science, and policy—in particular, his role in advising the UK government on the welfare of cephalopods and decapods. We discuss what it means to be sentient and what the brain basis of sentience might be. We sketch his precautionary framework for dealing with the wide-ranging debates and rampant uncertainty around these issues. We talk about several prominent edge cases in the natural world. And, finally, we consider whether AI might become sentient and, if so, by what route. Along the way, Jonathan and I touch on: plants, crayfish, bees, larvae, and LLMs. We talk about "sentience candidates" and the "zone of reasonable disagreement"; about Jonathan's stances on octopus farming and live-boiling of crabs; about the “run-ahead principle” and the “gaming problem”; and about the question of whether all conscious experience has a valence. Jonathan's book is a remarkably clear and compelling read—if you find yourself intrigued by our conversation, I definitely recommend that you check out The Edge of Sentience as well. Alright friends, without further ado, on to our sixth season of Many Minds and on to my conversation with Dr. Jonathan Birch. Enjoy! A transcript of this episode will be available soon. Notes and links 3:00 – The full report prepared by Dr. Birch and colleagues for the UK government is available here. 4:30 – Listen to our earlier episode with Dr. Alex Schnell here. 7:00 – Dr. Birch's 2017 book, from an earlier chapter of his career during which he focused on kin selection and social behavior. 11:00 – A paper by Dr. Birch on the UK government's response to the pandemic. 16:00 – A classic 1958 paper on sentience by the philosopher Herbert Feigl. 20:30 – Read Dr. Birch's general audience essay on the case of live-boiling crabs. 28:30 – Advocates of the idea that regions of the midbrain support sentience include Antonio Damasio, Jaak Panskepp (whose work we discussed in this earlier episode), and Bjorn Merker (whose work we discussed in this earlier episode).  31:30 – A discussion of the possibility of sentience in plants, with former guest Paco Calvo. 34:30 – Peter Godfrey Smith's recent book, Metazoa. 35:30 – A paper by Dr. Birch and colleagues titled ‘Dimensions of animal consciousness.' 39:30 – A study reporting conditioned place avoidance in octopuses. 40:30 – A study reporting anxiety-like states in crayfish. 42:00 – A primer on "nociception" (which Kensy mispronounces in this segment). 44:00 – A popular article by Dr. Birch and colleagues arguing against octopus farming. 47:00 – A paper about welfare concerns in farmed insects. 49:00 – A paper showing that bees will selectively groom an antenna that was touched with a heat probe. 51:00 – The OpenWorm project. 1:02:00 – A recent piece by Dr. Birch and former guest Kristin Andrews about developing better markers for understanding AI sentience. The question of defining “markers” of conscious experience was also a central topic of our recent episode with Tim Bayne.   Recommendations Other Minds, Peter Godfrey-Smith The Mind of a Bee, Lars Chittka Justice for Animals, Martha Nussbaum   Many Minds is a project of the Diverse Intelligences Summer Institute, which is made possible by a generous grant from the John Templeton Foundation to Indiana University. The show is hosted and produced by Kensy Cooperrider, with help from Assistant Producer Urte Laukaityte and with creative support from DISI Directors Erica Cartmill and Jacob Foster. Our artwork is by Ben Oldroyd. Our transcripts are created by Sarah Dopierala. Subscribe to Many Minds on Apple, Stitcher, Spotify, Pocket Casts, Google Play, or wherever you listen to podcasts. You can also now subscribe to the Many Minds newsletter here! We welcome your comments, questions, and suggestions. Feel free to email us at: manymindspodcast@gmail.com.  For updates about the show, visit our website or follow us on Twitter (@ManyMindsPod) or Bluesky (@manymindspod.bsky.social).

In maart volgde ik een webinar van Hay To You met Marc Jansen van Metazoa. Ik denk dat Marc veel kennis heeft waar de paardenwereld baat bij heeft, en deel dan ook graag een aantal goede inzichten uit dit webinar. Kijk het webinar hier zelf: https://www.youtube.com/watch?v=DfYWcTUlVe8 Kwalituur Podcast met Marc: https://open.spotify.com/episode/1RmRcPDysWk218whZA42sl?si=f5b20b6499f64180

Den australske blækspruttefilosof Peter Godfrey-Smith er ikke i tvivl. Intelligent liv er opstået to gange på Jorden: hos os mennesker og hos blæksprutterne. Hvis vi vil finde andre intelligente livsformer, behøver vi ikke lede i fjerne galakser med dyre rumteleskoper. De findes her på vores blå planet – og kan observeres med snorkel og dykkermaske. Siden 2009 har Godfrey-Smith sammen med marinbiologer studeret blækspruttesamfundet Octopolis i Jervis-bugten ud for Sydney og forsøgt at sætte sig ind i blækspruttens verden. Med sine mærkelige arme med mere end tusind sugekopper er den ottearmede blæksprutte lidt af en alien på jord. I sin bog 'Other Minds – The Octopus and the Evolution of Intelligent Life' fra 2016 genfortæller Godfrey-Smith denne aliens fascinerende evolutionshistorie. Siden vores seneste fælles forfader, der var en hjerneløs fladorm, levede for 600 millioner år siden, har blæksprutten fulgt en helt anden vej i livets træ end os og udviklet et ejendommeligt centralnervesystem, hvor 320 millioner af dens mere end 500 neuroner findes i armene, der kan agere mere eller mindre uafhængigt af dens hjerne. Selvom vi i dag ved en masse om blækspruttens mærkværdige fysiologi, er dens verden efter alt at dømme radikalt anderledes end vores. For hvordan er det i grunden at være en blæksprutte? Og hvad siger det om bevidsthed og intelligens i det hele taget? ** Peter Godfrey-Smith er en af verdens førende videnskabsfilosoffer og professor ved University of Sydney i Australien. Han er forfatter til flere bøger, heriblandt de internationale bestsellere ‘Other Minds' og ‘Metazoa'.

In this GABF Gold! edition of the podcast, the last of our 2023 focus on GABF gold medal winners, Jamie is joined by Rob Malad, director of brewing operations for Metazoa (https://www.metazoabrewing.com) in Indianapolis, Indiana. Metazoa recently won gold for William Walrus, a Scottish-style ale and product of necessity, that employed brewing techniques to overcome ingredient challenges while staying true to the spirit of the style. In this episode, he touches on: brewing beers meant to be consumed more than once using double decoction to build malt character in lieu of a broad range of speciality malt building a recipe with pale malt, Munich malt, and small amounts of low-Lovibond speciality malts but no English malts using English ale yeast typically employed in their hazy IPA brewing with minimal hops but balancing with carbonation their medal-winning approach to saison the mouthfeel impression of high Saaz loads elements that set beers apart in competition And more. This episode is brought to you by: G&D Chillers (https://gdchillers.com): For years G&D Chillers has chilled the beers you love, partnering with 3,000+ breweries across the country along the way, and they're proud of the cool partnerships they've built over the past 30 years. Reach out for a quote today at gdchillers.com (http://www.Gdchillers.com) or call to discuss your next project. BSG Craft Brewing (https://Bsgcraftbrewing.com/): BSG invites you to experience one of the newest hops from their Hop Solutions line, HS Grove™. Developed for hop-forward beer styles, HS Grove boasts incredible biotransformation qualities, giving you the power to transform your next IPA into a stone fruit powerhouse. Visit BSGCraftbrewing.com to learn more. Old Orchard (https://www.oldorchard.com/brewer): Old Orchard's new brewing customers often mention discovering Old Orchard through the word-of-mouth recommendation of another brewer. To join the core of Old Orchard's brewing community, learn more at oldorchard.com/brewer (https://www.oldorchard.com/brewer) Accubrew (https://accubrew.io) The AccuBrew system is designed to give you unprecedented insight into the fermentation process. Monitor gravity, fermentation activity, clarity, and temperature, schedule reminders, and receive alerts anywhere, anytime. To learn more about AccuBrew head over to AccuBrew.io ProBrew (https://www.probrew.com) The ProFill series of rotary can fillers from ProBrew are accelerating plant production everywhere. For more information, visit www.probrew.com or email contactus@probrew.com. ZBiotics (https://zbiotics.com/pages/beerandbrewing) We all have busy lives these days and can't afford to waste a day stuck on the couch because of a few drinks the night before. ZBiotics is the answer we've all been looking for. ZBiotics is the world's first genetically engineered probiotic invented by PhD scientists to tackle rough mornings after drinking. Give ZBiotics a try for yourself. Go to zbiotics.com/BEERANDBREWING (https://zbiotics.com/pages/beerandbrewing) to get 15% off your first order when you use BEERANDBREWING at checkout. ZBiotics is backed with 100% money back guarantee so if you're unsatisfied for any reason, they'll refund your money, no questions asked. Omega Yeast (https://omegayeast.com): Thiolized yeast are a new tool for brewers to bring intense guava and passionfruit aromas out of your malt and hops. And wait, there's more! Omega Yeast makes yeast-to-order with a consistent one week lead time ensuring peak freshness and reliability. The Perfect Purée (https://perfectpuree.com/beer): The Perfect Purée is offering a free sample box of their frozen fruit purees, concentrates and blends to professional brewers. Choose from 40 plus flavors and build a free sample box at perfectpuree.com/beer. Complimentary to professionals only. Yakima Chief Hops (https://www.yakimachief.com/pink-boots-blend): The 7th Annual Pink Boots Blend is now available for pre-order! $3 of every pound of the Pink Boots Blend purchased will be donated to the Pink Boots Society, a nonprofit organization that support women and non-binary individuals in the fermented and alcoholic industry through education. Learn more at www.yakimachief.com/pink-boots-blend

Today on the podcast we hear from Metazoa Brewing Vice President Lauren Frederick. Lauren's background is in sales and marketing, but she shares her tips and tactics to learn the financial aspects of running a brewery. Many brewery operators are non-financial managers. In today's episode you'll hear Lauren's journey from sales rep to vice president and the financial knowledge she learned along the way. Key TopicsMetazoa's brewery financial planning processSoftware stack, key metrics, and compensation structures Favorite industry publications, resources, and podcasts ResourcesConnect with Lauren Frederick - Lauren@metazoa.beerJoin the beer industry finance group

Intelligent Assistant to Manage Salesforce Orgs with AI, Launched, Metazoa Podcast: Enables Salesforce Administrators to remove technical debt Recently, Metazoa, the leading provider of administrative tools for Salesforce, announced the launch of Intelligent Assistant on the Salesforce AppExchange. Jennifer Mercer is the CEO of Metazoa, discusses this announcement and gives us an overview of her company. Metazoa's mission is to build, support and sell the world's finest Org Management application for Salesforce Administrators. We learn in this podcast that not only are customers enthusiastic about the new offering, but they are discovering new ways to use it. Metazoa is an AI pioneer who recently debuted their tools at Dreamforce. Intelligent Assistant includes Metadata Studio, a prompt engineering platform, and Intelligent Search, an administrative thinking partner. These new tools give Metazoa customers the ability to virtually expand their administrative headcount using artificial intelligence. This one-two punch represents the most significant use of AI on the Salesforce platform to date. Metadata Studio is a prompt engineering platform (PEP) that seamlessly integrates AI with customer metadata. The use of grounding data, best practices, and few-shot learning make these prompts practical workhorses capable of solving difficult administrative problems. Examples include coding Apex Classes, documenting Flows, building Validation Rules, writing SOQL Filters, and creating Formula Fields. Metadata Studio helps customers manage their prompts. About Metazoa: Metazoa provides a comprehensive suite of AI empowered tools that enable Salesforce Administrators to remove technical debt, optimize security, improve compliance, increase productivity, and lower the total cost of org ownership. Technical debt can result in slow performance, reduced agility, sluggish adoption, and the failure to meet business requirements. Metazoa Snapshot can help you discover technical debt problems and then fix them. When your org is back up and running, Snapshot can also help you maintain the org so that technical debt does not return. Learn about https://www.metazoa.com/ More news on AI

Metazoa Brewing Hoppopotamus is an American IPA by style. The Hoppopotamus may be gentler than its unpredictable hippo cousin, but don't let the balanced flavor profile fool you. It's full of surprises. Best appreciated from a wide mouthed glass, the aroma is bright with notes of grapefruit, orange peel, and tropical fruit. A burst of floral bitterness from the Citra and Mosaic hops is balanced by a soft sweetness from a light-handed dose of Vienna malt.. This craft beer is 7% ABV and 70 IBUs. In this craft beer review, we will take a look at the color, smell, and taste.

A discussion on the intelligence of octopuses and cuttlefish, and on the origins of consciousness, with celebrated writer and philosopher, Peter Godfrey-Smith. Peter is Professor in the School of History and Philosophy of Science at the University of Sydney. He is the author, among others, of Other Minds and Metazoa. You can read more about his work here: https://petergodfreysmith.com/

El guitarrista de la banda mexicana de metal progresivo Metazoa, nos revela sus experiencias paranormales y de posible abducción, acompañado de su talento metalero. Metazoa https://youtube.com/channel/UCyQev2KnEKKYh2rWBsj2RYQ Siguenos en nuestras redes sociales: 1. YouTube Pesadilla's radio https://youtube.com/channel/UCIt9KrJiFy61W4lW5SfEDLQ 2. YouTube El pesadillero https://youtube.com/channel/UCdGBKMhRCYiTjc6i3hqPT5g 3. Podcast Terror y metal https://open.spotify.com/episode/0YHe1dRd6o49tml34aklUt?si=Hsl2EayRQA-K5KTN3DtDJA 4. Tweeter @d_relatos 5. PAYPAL para donaciones (gracias) https://www.paypal.me/LuisMontane969 6. Mándame tu testimonio por audio o por escrito a mi número de whattsapp 001-956-307-2332 TODAS LAS HISTORIAS SERAN PUBLICADAS! Yo NO rechazo tu relato! Al contrario agradezco tu confianza. 7. Canal de YouTube “Larga Vida Metal latinoamericano https://youtube.com/channel/UCb-zgtwrf_Neq4_vomST60g

El baterista vocalista de la banda mexicana de metal progresivo Metazoa https://youtube.com/channel/UCyQev2KnEKKYh2rWBsj2RYQ no se revela su experiencia de terror mientras él estudiaba la carrera de criminología en la ciudad de México, acompañado de su talento metalero. Siguenos en nuestras redes sociales: 1. YouTube Pesadilla's radio https://youtube.com/channel/UCIt9KrJiFy61W4lW5SfEDLQ 2. YouTube El pesadillero https://youtube.com/channel/UCdGBKMhRCYiTjc6i3hqPT5g 3. Podcast Terror y metal https://open.spotify.com/episode/0YHe1dRd6o49tml34aklUt?si=Hsl2EayRQA-K5KTN3DtDJA 4. Tweeter @d_relatos 5. PAYPAL para donaciones (gracias) https://www.paypal.me/LuisMontane969 6. Mándame tu testimonio por audio o por escrito a mi número de whattsapp 001-956-307-2332 TODAS LAS HISTORIAS SERAN PUBLICADAS! Yo NO rechazo tu relato! Al contrario agradezco tu confianza. Historias macabras para no dormir https://www.facebook.com/Historiasmacabras

When it comes to exploring the mind-boggling complexity of living systems—ranging from the origins of human consciousness to treatments for neurodegenerative diseases such as Alzheimer's—Susan Fitzpatrick has long been a critic of reductionist thinking. In this episode we talk with Fitzpatrick, who has spent three decades supporting brain research as president of the James S. McDonnell Foundation, about new ways to understand the human brain, the difficulty of developing an effective Alzheimer's treatment, and how scientific research can successfully confront complex problems. Further reading: The James S. McDonnell Foundation website Susan Fitzpatrick's review of Metazoa by Peter Godfrey-Smith and Life's Edge by Carl Zimmer Her review of Brains Through Time by Georg F. Striedter and R. Glenn Northcutt Her review of Mind Fixers by Anne Harrington Her review of Chasing Men on Fire by Stephen G. Waxman and Understanding the Brain by John E. Dowling “Asking the Right Questions in Alzheimer's Research,” her Feature essay in the Fall 2018 Issues in Science and Technology

In his new book, Metazoa, Australia's ‘scuba-diving philosopher' Peter Godfrey-Smith explores the evolution of animal consciousness through the inner workings of a cast of marine characters - everything from soft coral and glass sponges to hermit crabs and banded shrimp.

Si parla con Chiara Caprio di Animal Equality Italia della inchiesta sui Wet market in India, di zoonosi, di covid, ma anche della Giornata mondiale del Polpo, di Peter Godfrey Smith, di Altre Menti, di Adelphi, di Metazoa , il nuovo libro di Peter Godfrey Smith edito da Adelphi, di allevamento di polpi, di CIWF Italia, di Progetto Arca, di Cascina Vita Nova Giorgina Venosta, di senza dimora con cani, di Enpa Monza Brianza, di bracconaggio, di gatto, di Capriolo, di referendum comitatosi aboliamo la caccia

Peter Godfrey-Smith knows his cephalopods. Once of CUNY and now a professor of history and philosophy of science at University of Sydney, his truly capacious career includes books such as Theory and Reality (2003; 2nd edition in 2020), Darwinian Populations and Natural Selection (2009) and most recently Metazoa. RtB--including two Brandeis undergraduates as guest hosts, Izzy Dupré and Miriam Fisch-- loves his astonishing book on the fundamental alterity of octopus intelligence and experience of the world, Other Minds: The Octopus, the Sea and the Deep Origins of Consciousness. Another equally descriptive title for that book, and for the discussion we share with you here (after Thomas Nagel's "What is it like to be a Bat?") might be What is it Like to be an Octopus? As always, below you will find helpful links for the works referenced in the episode, and a transcript for those who prefer or require a print version of the conversation. Please visit us at Recallthisbook.org (or even subscribe there) if you are interested in helpful bonus items like related short original articles, reading lists, visual supplements and past episodes grouped into categories for easy browsing. Mentioned in the Episode: --Adrian Tchaikovsky, Children of Ruin --"Open the pod bay doors, Hal": a chilling line from 2001: A Space Odyssey (1968) --District Nine (2009, dir. Neill Bloomkamp) in which giant intelligent shrimp from outer space play the role of octopus-like alien intelligence, and prompt a complex but unmistakably racist reaction on their arrival in South Africa. --Charles Darwin, The Expression of the Emotions in Man and Animals (1872) --Erik Linklater, Pirates in the Deep Green Sea (1949) Transcript Finally, all listeners and readers who are interested in the gentle art of podcasting are cordially invited to the inaugural Humanities Podcasting Symposium, held over Zoom, October 15-16. Latif Nasser of Radiolab will headline two days of workshops, seminars and discussions among scholars students and amateurs who have fallen in love with the pedagogical and intellectual possibilities the medium affords. Elizabeth and John will both be presenting. Join us. RSVP here Elizabeth Ferry is Professor of Anthropology at Brandeis University. Email: ferry@brandeis.edu. John Plotz is Barbara Mandel Professor of the Humanities at Brandeis University and co-founder of the Brandeis Educational Justice Initiative. Email: plotz@brandeis.edu. Learn more about your ad choices. Visit megaphone.fm/adchoices

Si parla con Chiara Caprio di Animal Equality Italia della inchiesta sui Wet market in India, di zoonosi, di covid, ma anche della Giornata mondiale del Polpo, di Peter Godfrey Smith, di Altre Menti, di Adelphi, di Metazoa , il nuovo libro di Peter Godfrey Smith edito da Adelphi, di allevamento di polpi, di CIWF Italia, di Progetto Arca, di Cascina Vita Nova Giorgina Venosta, di senza dimora con cani, di Enpa Monza Brianza, di bracconaggio, di gatto, di Capriolo, di referendum comitatosi aboliamo la caccia

Peter Godfrey-Smith knows his cephalopods. Once of CUNY and now a professor of history and philosophy of science at University of Sydney, his truly capacious career includes books such as Theory and Reality (2003; 2nd edition in 2020), Darwinian Populations and Natural Selection (2009) and most recently Metazoa. RtB--including two Brandeis undergraduates as guest hosts, Izzy Dupré and Miriam Fisch-- loves his astonishing book on the fundamental alterity of octopus intelligence and experience of the world, Other Minds: The Octopus, the Sea and the Deep Origins of Consciousness. Another equally descriptive title for that book, and for the discussion we share with you here (after Thomas Nagel's "What is it like to be a Bat?") might be What is it Like to be an Octopus? As always, below you will find helpful links for the works referenced in the episode, and a transcript for those who prefer or require a print version of the conversation. Please visit us at Recallthisbook.org (or even subscribe there) if you are interested in helpful bonus items like related short original articles, reading lists, visual supplements and past episodes grouped into categories for easy browsing. Mentioned in the Episode: --Adrian Tchaikovsky, Children of Ruin --"Open the pod bay doors, Hal": a chilling line from 2001: A Space Odyssey (1968) --District Nine (2009, dir. Neill Bloomkamp) in which giant intelligent shrimp from outer space play the role of octopus-like alien intelligence, and prompt a complex but unmistakably racist reaction on their arrival in South Africa. --Charles Darwin, The Expression of the Emotions in Man and Animals (1872) --Erik Linklater, Pirates in the Deep Green Sea (1949) Transcript Finally, all listeners and readers who are interested in the gentle art of podcasting are cordially invited to the inaugural Humanities Podcasting Symposium, held over Zoom, October 15-16. Latif Nasser of Radiolab will headline two days of workshops, seminars and discussions among scholars students and amateurs who have fallen in love with the pedagogical and intellectual possibilities the medium affords. Elizabeth and John will both be presenting. Join us. RSVP here Elizabeth Ferry is Professor of Anthropology at Brandeis University. Email: ferry@brandeis.edu. John Plotz is Barbara Mandel Professor of the Humanities at Brandeis University and co-founder of the Brandeis Educational Justice Initiative. Email: plotz@brandeis.edu. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/animal-studies

Peter Godfrey-Smith knows his cephalopods. Once of CUNY and now a professor of history and philosophy of science at University of Sydney, his truly capacious career includes books such as Theory and Reality (2003; 2nd edition in 2020), Darwinian Populations and Natural Selection (2009) and most recently Metazoa. RtB--including two Brandeis undergraduates as guest hosts, Izzy Dupré and Miriam Fisch-- loves his astonishing book on the fundamental alterity of octopus intelligence and experience of the world, Other Minds: The Octopus, the Sea and the Deep Origins of Consciousness. Another equally descriptive title for that book, and for the discussion we share with you here (after Thomas Nagel's "What is it like to be a Bat?") might be What is it Like to be an Octopus? As always, below you will find helpful links for the works referenced in the episode, and a transcript for those who prefer or require a print version of the conversation. Please visit us at Recallthisbook.org (or even subscribe there) if you are interested in helpful bonus items like related short original articles, reading lists, visual supplements and past episodes grouped into categories for easy browsing. Mentioned in the Episode: --Adrian Tchaikovsky, Children of Ruin --"Open the pod bay doors, Hal": a chilling line from 2001: A Space Odyssey (1968) --District Nine (2009, dir. Neill Bloomkamp) in which giant intelligent shrimp from outer space play the role of octopus-like alien intelligence, and prompt a complex but unmistakably racist reaction on their arrival in South Africa. --Charles Darwin, The Expression of the Emotions in Man and Animals (1872) --Erik Linklater, Pirates in the Deep Green Sea (1949) Transcript Finally, all listeners and readers who are interested in the gentle art of podcasting are cordially invited to the inaugural Humanities Podcasting Symposium, held over Zoom, October 15-16. Latif Nasser of Radiolab will headline two days of workshops, seminars and discussions among scholars students and amateurs who have fallen in love with the pedagogical and intellectual possibilities the medium affords. Elizabeth and John will both be presenting. Join us. RSVP here Elizabeth Ferry is Professor of Anthropology at Brandeis University. Email: ferry@brandeis.edu. John Plotz is Barbara Mandel Professor of the Humanities at Brandeis University and co-founder of the Brandeis Educational Justice Initiative. Email: plotz@brandeis.edu. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

No Happy Hour #23 due to technical difficulties, so we'll skip right to the Real Deal...social media -- our firsts and our thoughts on using social media now. Branden: Confluence Brewing Co. Light & Squeezy Lemon Raspberry Radler Jimmy: Metazoa Brewing Co. Puppy Slumber Party Content Advisory: explicit language, alcohol --- Send in a voice message: https://anchor.fm/wastedinformation/message

In this episode of SaaS Connect by Cloud Software Association, Leslie Tom, Senior Vice President at AppExchange Salesforce, conducts a discussion between Mike Kreaden, MD of Salesforce Accelerate, Jason Briggs, Co-Founder of Diffeo (which was acquired by Salesforce in 2019) and Jennifer Mercer, Co-Founder and CEO of Metazoa, a current AppExchange partner. A multifaceted conversation, the focus is on how Salesforce takes ISVs from concept to AppExchange with Salesforce Accelerate, which aims to help ISVs get to market sooner. The discussion includes: Salesforce conversation The start of AppExchange and what was then called the Incubator; both launched in 2006. The Incubator was for the purpose of progressing from only a handful of apps to hundreds; two years later Salesforce boasted 800 apps and today, hundreds of thousands of apps. The purpose of the Incubator was to help businesses ultimately build thriving businesses around the AppExchange. In 2016, the Incubator was rebooted into the AppExchange program, and evolved to Salesforce Accelerate. From idea to AppExchange in just three months. The selection process for ISVs in Accelerator. Diffeo conversation At what stage of the Diffeo product and startup lifecycle did they apply to the program, and how much knowledge of the Salesforce ecosystem platform and products did they have at the time, and what Diffeo's goals were for entering the program. The unconventional way Diffeo raised funds. The resources Diffeo allocated to the Accelerate program. Metazoa conversation Although Metazoa was already a proven AppExchange partner, what were their goals on entering the program? Since there were around 6,000 apps on AppExchange, getting on the program gave them the opportunity to be relevant and get the exposure they needed. Highlights of the Accelerate program, and how the company is doing today. Takeaways from Diffeo and Metazoa Program takeaways, benefits of the program, insights and advice for other founders from both Diffeo and Metazoa. Resources Mentioned: Slack Dream Factory Dream Team Thank you to our amazing podcast team at Content Allies. Want to launch your own B2B revenue-generating podcasts? Contact them at https://ContentAllies.com

Bulunduğumuz haftanın bilim dünyasından önemli gelişmeleri sizler için derledik. New insights on interpersonal violence in the Late Pleistocene based on the Nile valley cemetery of Jebel Sahaba. https://doi.org/10.1038/s41598-021-89386-y Mapping single cell atlases throughout Metazoa unravels cell type evolution. https://doi.org/10.7554/elife.66747 Caffeine selectively mitigates cognitive deficits caused by sleep deprivation. https://doi.org/10.1037/xlm0001023 A global metagenomic map of urban microbiomes and antimicrobial resistance. https://doi.org/10.1016/j.cell.2021.05.002 Bize 101.podcast.info@gmail.com adresinden ulaşabilirsiniz.

Dip below the ocean's surface and you are soon confronted by forms of life that could not seem more foreign to our own: sea sponges, soft corals, and serpulid worms, whose rooted bodies, intricate geometry, and flower-like appendages are more reminiscent of plant life or even architecture than anything recognizably animal. Yet these creatures are our cousins. As fellow members of the animal kingdom—the Metazoa—they can teach us much about the evolutionary origins of not only our bodies, but also our minds. In his acclaimed 2016 book, Other Minds, the philosopher and scuba diver Peter Godfrey-Smith explored the mind of the octopus—the closest thing to an intelligent alien on Earth. In Metazoa: Animal Life and the Birth of the Mind (FSG, 2020), Godfrey-Smith expands his inquiry to animals at large, investigating the evolution of subjective experience with the assistance of far-flung species. As he delves into what it feels like to perceive and interact with the world as other life-forms do, Godfrey-Smith shows that the appearance of the animal body well over half a billion years ago was a profound innovation that set life upon a new path. In accessible, riveting prose, he charts the ways that subsequent evolutionary developments—eyes that track, for example, and bodies that move through and manipulate the environment—shaped the subjective lives of animals. Following the evolutionary paths of a glass sponge, soft coral, banded shrimp, octopus, and fish, then moving onto land and the world of insects, birds, and primates like ourselves, Metazoa gathers their stories together in a way that bridges the gap between mind and matter, addressing one of the most vexing philosophical problems: that of consciousness. Combining vivid animal encounters with philosophical reflections and the latest news from biology, Metazoa reveals that even in our high-tech, AI-driven times, there is no understanding our minds without understanding nerves, muscles, and active bodies. The story that results is as rich and vibrant as life itself. Peter Godfrey-Smith is a professor in the School of History and Philosophy of Science at the University of Sydney. He is the author of the bestselling Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness, which has been published in more than twenty languages. His other books include Theory and Reality: An Introduction to the Philosophy of Science and Darwinian Populations and Natural Selection, which won the 2010 Lakatos Award. Mark Molloy is the reviews editor at MAKE: A Literary Magazine. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Dip below the ocean's surface and you are soon confronted by forms of life that could not seem more foreign to our own: sea sponges, soft corals, and serpulid worms, whose rooted bodies, intricate geometry, and flower-like appendages are more reminiscent of plant life or even architecture than anything recognizably animal. Yet these creatures are our cousins. As fellow members of the animal kingdom—the Metazoa—they can teach us much about the evolutionary origins of not only our bodies, but also our minds. In his acclaimed 2016 book, Other Minds, the philosopher and scuba diver Peter Godfrey-Smith explored the mind of the octopus—the closest thing to an intelligent alien on Earth. In Metazoa: Animal Life and the Birth of the Mind (FSG, 2020), Godfrey-Smith expands his inquiry to animals at large, investigating the evolution of subjective experience with the assistance of far-flung species. As he delves into what it feels like to perceive and interact with the world as other life-forms do, Godfrey-Smith shows that the appearance of the animal body well over half a billion years ago was a profound innovation that set life upon a new path. In accessible, riveting prose, he charts the ways that subsequent evolutionary developments—eyes that track, for example, and bodies that move through and manipulate the environment—shaped the subjective lives of animals. Following the evolutionary paths of a glass sponge, soft coral, banded shrimp, octopus, and fish, then moving onto land and the world of insects, birds, and primates like ourselves, Metazoa gathers their stories together in a way that bridges the gap between mind and matter, addressing one of the most vexing philosophical problems: that of consciousness. Combining vivid animal encounters with philosophical reflections and the latest news from biology, Metazoa reveals that even in our high-tech, AI-driven times, there is no understanding our minds without understanding nerves, muscles, and active bodies. The story that results is as rich and vibrant as life itself. Peter Godfrey-Smith is a professor in the School of History and Philosophy of Science at the University of Sydney. He is the author of the bestselling Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness, which has been published in more than twenty languages. His other books include Theory and Reality: An Introduction to the Philosophy of Science and Darwinian Populations and Natural Selection, which won the 2010 Lakatos Award. Mark Molloy is the reviews editor at MAKE: A Literary Magazine. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dip below the ocean's surface and you are soon confronted by forms of life that could not seem more foreign to our own: sea sponges, soft corals, and serpulid worms, whose rooted bodies, intricate geometry, and flower-like appendages are more reminiscent of plant life or even architecture than anything recognizably animal. Yet these creatures are our cousins. As fellow members of the animal kingdom—the Metazoa—they can teach us much about the evolutionary origins of not only our bodies, but also our minds. In his acclaimed 2016 book, Other Minds, the philosopher and scuba diver Peter Godfrey-Smith explored the mind of the octopus—the closest thing to an intelligent alien on Earth. In Metazoa: Animal Life and the Birth of the Mind (FSG, 2020), Godfrey-Smith expands his inquiry to animals at large, investigating the evolution of subjective experience with the assistance of far-flung species. As he delves into what it feels like to perceive and interact with the world as other life-forms do, Godfrey-Smith shows that the appearance of the animal body well over half a billion years ago was a profound innovation that set life upon a new path. In accessible, riveting prose, he charts the ways that subsequent evolutionary developments—eyes that track, for example, and bodies that move through and manipulate the environment—shaped the subjective lives of animals. Following the evolutionary paths of a glass sponge, soft coral, banded shrimp, octopus, and fish, then moving onto land and the world of insects, birds, and primates like ourselves, Metazoa gathers their stories together in a way that bridges the gap between mind and matter, addressing one of the most vexing philosophical problems: that of consciousness. Combining vivid animal encounters with philosophical reflections and the latest news from biology, Metazoa reveals that even in our high-tech, AI-driven times, there is no understanding our minds without understanding nerves, muscles, and active bodies. The story that results is as rich and vibrant as life itself. Peter Godfrey-Smith is a professor in the School of History and Philosophy of Science at the University of Sydney. He is the author of the bestselling Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness, which has been published in more than twenty languages. His other books include Theory and Reality: An Introduction to the Philosophy of Science and Darwinian Populations and Natural Selection, which won the 2010 Lakatos Award. Mark Molloy is the reviews editor at MAKE: A Literary Magazine. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Dip below the ocean's surface and you are soon confronted by forms of life that could not seem more foreign to our own: sea sponges, soft corals, and serpulid worms, whose rooted bodies, intricate geometry, and flower-like appendages are more reminiscent of plant life or even architecture than anything recognizably animal. Yet these creatures are our cousins. As fellow members of the animal kingdom—the Metazoa—they can teach us much about the evolutionary origins of not only our bodies, but also our minds. In his acclaimed 2016 book, Other Minds, the philosopher and scuba diver Peter Godfrey-Smith explored the mind of the octopus—the closest thing to an intelligent alien on Earth. In Metazoa: Animal Life and the Birth of the Mind (FSG, 2020), Godfrey-Smith expands his inquiry to animals at large, investigating the evolution of subjective experience with the assistance of far-flung species. As he delves into what it feels like to perceive and interact with the world as other life-forms do, Godfrey-Smith shows that the appearance of the animal body well over half a billion years ago was a profound innovation that set life upon a new path. In accessible, riveting prose, he charts the ways that subsequent evolutionary developments—eyes that track, for example, and bodies that move through and manipulate the environment—shaped the subjective lives of animals. Following the evolutionary paths of a glass sponge, soft coral, banded shrimp, octopus, and fish, then moving onto land and the world of insects, birds, and primates like ourselves, Metazoa gathers their stories together in a way that bridges the gap between mind and matter, addressing one of the most vexing philosophical problems: that of consciousness. Combining vivid animal encounters with philosophical reflections and the latest news from biology, Metazoa reveals that even in our high-tech, AI-driven times, there is no understanding our minds without understanding nerves, muscles, and active bodies. The story that results is as rich and vibrant as life itself. Peter Godfrey-Smith is a professor in the School of History and Philosophy of Science at the University of Sydney. He is the author of the bestselling Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness, which has been published in more than twenty languages. His other books include Theory and Reality: An Introduction to the Philosophy of Science and Darwinian Populations and Natural Selection, which won the 2010 Lakatos Award. Mark Molloy is the reviews editor at MAKE: A Literary Magazine. Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/animal-studies

Dip below the ocean's surface and you are soon confronted by forms of life that could not seem more foreign to our own: sea sponges, soft corals, and serpulid worms, whose rooted bodies, intricate geometry, and flower-like appendages are more reminiscent of plant life or even architecture than anything recognizably animal. Yet these creatures are our cousins. As fellow members of the animal kingdom—the Metazoa—they can teach us much about the evolutionary origins of not only our bodies, but also our minds. In his acclaimed 2016 book, Other Minds, the philosopher and scuba diver Peter Godfrey-Smith explored the mind of the octopus—the closest thing to an intelligent alien on Earth. In Metazoa: Animal Life and the Birth of the Mind (FSG, 2020), Godfrey-Smith expands his inquiry to animals at large, investigating the evolution of subjective experience with the assistance of far-flung species. As he delves into what it feels like to perceive and interact with the world as other life-forms do, Godfrey-Smith shows that the appearance of the animal body well over half a billion years ago was a profound innovation that set life upon a new path. In accessible, riveting prose, he charts the ways that subsequent evolutionary developments—eyes that track, for example, and bodies that move through and manipulate the environment—shaped the subjective lives of animals. Following the evolutionary paths of a glass sponge, soft coral, banded shrimp, octopus, and fish, then moving onto land and the world of insects, birds, and primates like ourselves, Metazoa gathers their stories together in a way that bridges the gap between mind and matter, addressing one of the most vexing philosophical problems: that of consciousness. Combining vivid animal encounters with philosophical reflections and the latest news from biology, Metazoa reveals that even in our high-tech, AI-driven times, there is no understanding our minds without understanding nerves, muscles, and active bodies. The story that results is as rich and vibrant as life itself. Peter Godfrey-Smith is a professor in the School of History and Philosophy of Science at the University of Sydney. He is the author of the bestselling Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness, which has been published in more than twenty languages. His other books include Theory and Reality: An Introduction to the Philosophy of Science and Darwinian Populations and Natural Selection, which won the 2010 Lakatos Award. Mark Molloy is the reviews editor at MAKE: A Literary Magazine. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/psychology

Dip below the ocean’s surface and you are soon confronted by forms of life that could not seem more foreign to our own: sea sponges, soft corals, and serpulid worms, whose rooted bodies, intricate geometry, and flower-like appendages are more reminiscent of plant life or even architecture than anything recognizably animal. Yet these creatures are our cousins. As fellow members of the animal kingdom—the Metazoa—they can teach us much about the evolutionary origins of not only our bodies, but also our minds. In his acclaimed 2016 book, Other Minds, the philosopher and scuba diver Peter Godfrey-Smith explored the mind of the octopus—the closest thing to an intelligent alien on Earth. In Metazoa: Animal Life and the Birth of the Mind (FSG, 2020), Godfrey-Smith expands his inquiry to animals at large, investigating the evolution of subjective experience with the assistance of far-flung species. As he delves into what it feels like to perceive and interact with the world as other life-forms do, Godfrey-Smith shows that the appearance of the animal body well over half a billion years ago was a profound innovation that set life upon a new path. In accessible, riveting prose, he charts the ways that subsequent evolutionary developments—eyes that track, for example, and bodies that move through and manipulate the environment—shaped the subjective lives of animals. Following the evolutionary paths of a glass sponge, soft coral, banded shrimp, octopus, and fish, then moving onto land and the world of insects, birds, and primates like ourselves, Metazoa gathers their stories together in a way that bridges the gap between mind and matter, addressing one of the most vexing philosophical problems: that of consciousness. Combining vivid animal encounters with philosophical reflections and the latest news from biology, Metazoa reveals that even in our high-tech, AI-driven times, there is no understanding our minds without understanding nerves, muscles, and active bodies. The story that results is as rich and vibrant as life itself. Peter Godfrey-Smith is a professor in the School of History and Philosophy of Science at the University of Sydney. He is the author of the bestselling Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness, which has been published in more than twenty languages. His other books include Theory and Reality: An Introduction to the Philosophy of Science and Darwinian Populations and Natural Selection, which won the 2010 Lakatos Award. Mark Molloy is the reviews editor at MAKE: A Literary Magazine. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

In this episode I talk with Peter Godfrey-Smith, author of Metazoa, a book which explores consciousness from an evolutionary perspective. We talk about octopus arms, impudent tongues, and theories of consciousness, including panpsychism. Related links: Peter Godfrey-Smith homepage Metazoa on Amazon Other Minds on Amazon My discussion with Tam Hunt about panpsychism  

This week we're taking to John J. Hall, head brewer of Metazoa Brewing Co. in Indianapolis. He's had an incredible brewing journey, so we dig a bit into that, and also talk about the awesome charitable work that Metazoa does for animals!

Diver and philosopher, Peter Godfrey-Smith, author of Other Minds and Metazoa, among other works, discusses the origins of consciousness deep under the sea...

Philosopher and diver Peter Godfrey-Smith speaks in-depth about his new book, 'Metazoa: Animal Minds and the Birth of Consciousness'. Peter explains how conscious experience evolved from animals in the sea millions of years ago. He introduces us to some of the fascinating creatures he meets in his scuba dives; sponges, soft coral, banded shrimp, giant cuttlefish, and hermit crabs. Peter is a professor in the School of History and Philosophy of Science at The University of Sydney. Broadcast on 9 February 2021.

Laura Tingle with the latest from Canberra, Satyajit Das on the GameStop rollercoaster and Peter Godfrey-Smith on the evolution of animal consciousness.

Laura Tingle with the latest from Canberra, Satyajit Das on the GameStop rollercoaster and Peter Godfrey-Smith on the evolution of animal consciousness.

In his new book, Metazoa, Australia’s ‘scuba-diving philosopher’ Peter Godfrey-Smith explores the evolution of animal consciousness through the inner workings of a cast of marine characters - everything from soft coral and glass sponges to hermit crabs and banded shrimp.

Dip below the ocean’s surface and you are soon confronted by forms of life that could not seem more foreign to our own: sea sponges, soft corals, and serpulid worms, whose rooted bodies, intricate geometry, and flower-like appendages are more reminiscent of plant life or even architecture than anything recognizably animal. Yet these creatures are our cousins. As fellow members of the animal kingdom―the Metazoa―they can teach us much about the evolutionary origins of not only our bodies, but also our minds. In his acclaimed 2016 book, Other Minds, the philosopher and scuba diver Peter Godfrey-Smith explored the mind of the octopus―the closest thing to an intelligent alien on Earth. In Metazoa, Godfrey-Smith expands his inquiry to animals at large, investigating the evolution of subjective experience with the assistance of far-flung species. As he delves into what it feels like to perceive and interact with the world as other life-forms do, Godfrey-Smith shows that the appearance of the animal body well over half a billion years ago was a profound innovation that set life upon a new path. In accessible, riveting prose, he charts the ways that subsequent evolutionary developments―eyes that track, for example, and bodies that move through and manipulate the environment―shaped the subjective lives of animals. Following the evolutionary paths of a glass sponge, soft coral, banded shrimp, octopus, and fish, then moving onto land and the world of insects, birds, and primates like ourselves, Metazoa gathers their stories together in a way that bridges the gap between mind and matter, addressing one of the most vexing philosophical problems: that of consciousness. Combining vivid animal encounters with philosophical reflections and the latest news from biology, Metazoa reveals that even in our high-tech, AI-driven times, there is no understanding our minds without understanding nerves, muscles, and active bodies. The story that results is as rich and vibrant as life itself.

What does it mean to have a mind? And how does our physical body inform our subjective idea of the world? In the Drawing Room, Peter Godfrey-Smith explores his latest book, Metazoa, and explains what the evolution of life can tell us about consciousness and the mind.

Meet Jennifer Mercer, serial entrepreneur and female founder of Metazoa, a #1 tool for Salesforce.com. She shares lessons learned around fundraising, scaling too fast, equity dilution and leadership. "Entrepreneurialism has high highs and low lows."

Meet Jennifer Mercer, serial entrepreneur and  female founder of Metazoa, a #1 tool for Salesforce.com. She shares lessons learned around fundraising, scaling too fast, equity dilution and leadership. "Entrepreneurialism has high highs and low lows."

All original content by Aron Ra. Visit his YouTube channel at youtube.com/aronra to watch the original video content. To support Aron Ra and his work, consider becoming a patron at patreon.com/aronra. Listen to this and other episodes of the Aron Ra Archive on: Apple Podcasts: https://apple.co/2I9Cdv3 Google Podcasts: https://bit.ly/2XzG6yB Spotify: https://spoti.fi/2FpgPQx Website: www.verygoodpodcast.com/aronrapod

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.28.317784v1?rss=1 Authors: Tarashansky, A. J., Musser, J., Khariton, M., Li, P., Arendt, D., Quake, S. R., Wang, B. Abstract: Comparing single-cell transcriptomic atlases from diverse organisms can provide evolutionary definition of cell types, elucidate the origins of cellular diversity, and transfer cell type knowledge between species. Yet, comparison among distant relatives, especially beyond a single phylum, is hindered by complex gene histories, lineage-specific inventions, and cell type evolutionary diversifications. Here, we develop a method to enable mapping cell atlases throughout Metazoa spanning sponge to mouse. Within phyla, we identify homologous cell types, even between distant species, with some even emerging from distinct germ layers. Across phyla, we find ancient cell type families that form densely interconnected groups, including contractile and stem cells, indicating they likely arose early in animal evolution through hierarchical diversifications. These homologous cell types often substitute paralog expressions at surprising prevalence. Our findings advance the understanding of cell type diversity across the tree of life and the evolution of associated gene expression programs. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.09.289108v1?rss=1 Authors: Spence, M. A., Mortimer, M., Buckle, A. M., Jackson, C. J. A. Abstract: Serine protease inhibitors (serpins) are found in all kingdoms of life and play essential roles in multiple physiological processes. Owing to the diversity of the superfamily, phylogenetic analysis is challenging and prokaryotic serpins have been speculated to have been acquired from Metazoa through horizontal gene transfer (HGT) due to their unexpectedly high homology. Here we have leveraged a structural alignment of diverse serpins to generate a comprehensive 6000-sequence phylogeny that encompasses serpins from all kingdoms of life. We show that in addition to a central hub of highly conserved serpins, there has been extensive diversification of the superfamily into many novel functional clades. Our analysis indicates that the hub proteins are ancient and are similar because of convergent evolution, rather than the alternative hypothesis of HGT. This work clarifies longstanding questions in the evolution of serpins and provides new directions for research in the field of serpin biology. Copy rights belong to original authors. Visit the link for more info

In the episode in our Indiana Made series, we talk to Lauren Frederick,  VP of Metazoa Brewing Company.  Metazoa Brewing Co. was founded in 2016 by Dave Worthington who was a homebrewer, animal-lover, and overall craft-beer enthusiast. Dave and his family had always enjoyed donating to animal charities and fostering rescued animals, but as Dave began dreaming of owning a brewery, he realized that he wanted to offer something even more special – so Metazoa was born. Since that day, Dave has continued to build the company around a promise to donate five percent of all company profits to unique animal charities in Indiana and beyond. If you want to try any of the beers Matt and JIll tasted on the show you can ORDER ONLINE or from the BIG RED LIQUORS APP for Curbside Pickup Service. It's as easy as 1,2,3! Start Your Order -  bigredliquors.com Simply select your store, browse and search for Metazoa Brewing products and start a CURBSIDE order. Your store will notify you when it is ready for pickup. Best of all, our NO TOUCH curbside will leave you with peace of mind and the great products you want ASAP. Current daily hours of operation are 12pm - 8pm.

We get wild this week with the President of the Indianapolis Zoo and self-proclaimed Biophiliac, Dr. Rob Shumaker. Dr. Rob knew what he wanted to be when he grew up early in his childhood because he enjoyed visiting the Smithsonian National Zoo’s Great Ape exhibit. After graduating from college, his life came full circle when he began working at the Smithsonian National Zoo with the apes he used to watch as a kid. He attributes much of his success to the non-judgemental support of his family to follow his dreams. After 20 years at the National Zoo, Dr. Rob moved to Iowa to work at the Great Ape Trust and, ultimately, Indianapolis to be the President of the Indianapolis Zoo. Although he loves all of the Great Apes, Rob’s favorite is the Orangutan. He shares with us many entertaining facts about the species, some from the books he has written. Tune in to learn about the purpose of zoos, about the internationally respected Indianapolis Prize, and about how you can make a difference with conservation efforts. Drink deep of the culture that surrounds you with Dr. Rob Shumaker from the Indianapolis Zoo. Learn about Indianapolis Zoo! Review the episode on iTunes, Twitter, and Facebook! Join our community on Patreon! What we tasted from Metazoa Brewing Co.Nap in the Hammock Cream Ale Black Mamba Pale Ale Check out our sponsors for this episode: Naptown Fitness - To start your health journey today, visit naptownfitness.com http://naptownfitness.com/ Drink Culture Community Workout https://www.instagram.com/naptownfitness/ https://www.facebook.com/NapTownFitness FullStack PEO - Turnkey HR for Emerging Companies. https://www.fullstackpeo.com/drnkcltr https://www.linkedin.com/company/27092746/ https://twitter.com/fullstackpeo https://www.facebook.com/pages/category/Consulting-Agency/FullStack-PEO-1107694849373703/ Butler Arts Centerhttps://butlerartscenter.org/eventshttps://butlerartscenter.org/event/tchaikovskys-nutcrackerhttps://butlerartscenter.org/event/rudolph-red-nosed-reindeer-musical Drink Culture Website: https://www.drnkcltr.com Drink Culture Newsletter: https://www.drnkcltr.com/newsletter/ Drink Culture Patreon: https://www.patreon.com/drnkcltr Drink Culture Instagram: https://www.instagram.com/drinkculturepodcast/ Drink Culture Facebook: https://www.facebook.com/drinkculturepodcast Drink Culture YouTube: https://www.youtube.com/channel/UCvrw7Fqfw4ZORgZMPJKio-A  

Listeners "Champagne" and "Kandi" join us behind the mic at Metazoa Brewing Company for our official launch of Season 2. We get into a lot of things, but seem to spend the most time on stories from our student teacher experiences. 

The Off Duty ADs talk about the effect of socioeconomics on youth sports; Ryan finds the positive in high sports club fees, wants high school coaches who are active in youth clubs, and loves a good kitten slumber party; Mike hypes the bargain of school-based sports, gives advice about dealing with habitual drop-ins, and does some math; Mark fixes college sports in under 9 minutes, relates character-based athletics to tax dollars, and supports the Kumite.

The pigs take on Westfield at the 3rd annual Rock the Junction (A beer fest that’s all about local charity) sponsored by none other than Grand Junction Brewing.  Jordan, Doug Fresh, Pauline G, and Tex Mex along with their security guard Griswold try beer from many breweries along with some special guest interviews from Grand Junction, Taxman, mad Anthony, Tin Man, Ash & Elm Cider Co., Four Day Ray and even Evan Williams himself.  Learn about the horrible prank played on Jordan by the Great Jonathon Mullens and the other pigs, Find the cure for erectile dysfunction, New beers, the Milf Stout and Stripper Dust, and much more on this long episode of Blind Pig Confessions.  Shout-outs to:  FDR, Metazoa, MashCraft, Bier, Foam Blowers, Ash & Elm Cider Co., Broadripple Brew Pub, Jonathon Mullens, Redemption Alewerks, Brew Link, Moontown, Round Town, Mad Anthony, Tin Man, Taxman, Wooden Bear, Mind Over Mash, Deviate Brewing, Union Brewing, Pax Verum, Jan’s Village Pizza 

Let us take you on a journey.  A journey back in time, to the year 1994 when Brendan had flowing lochs and was headbanging to his favorite 70’s metal bands, Pat had brown hair and was wearing his signature shell necklace, and Jordan actually had hair.  Wait!  It’s not the 90s it is Savor Lebanon.   The boys head up north to attend this once a year beer, wine, and food festival.   The DJ this year made us feel nostalgic for our youth as he turned out all the best and worst of the 90’s.  Indiana On Tap again hosts a great festival with great breweries represented.   We get to sit down with Erin Edds the owner/co-founder of Garden Party (crafted cocktails anyone), Allison Zook or Cardinal Spirits joins us to discuss their impressive line of craft spirits and liqueurs.  We had some of their coffee liqueur in a milk stout and it created heaven on earth.  We got to speak to Tell City about their triple boner and the Pour house their impressive tap room down south.   Tune into this episode for some hilarious antics and good-hearted fun.   Should brewing beer be a boy scout merit badge?  What is that burning sensation in Pat’s pants? Why are the guys giggling so much about the Boner?  What happens when 2 drunk guys show up with peach candy necklaces?   All these and many more questions will be answered for you on this episode of Blind Pig Confessions. Explicit Episode Shout Outs:  Brewlink, Cardinal Spirits, Bier Brewery, Sun King, Cedar Creek, Metazoa, Tipsy Turvey, Rock Bottom, Tell City, Moontown, Arni’s

Nobelsville Brewfest was such an amazing event and the weather could not have been better. So many great beers and wines to choose from and the crowd was fantastic. It was the perfect way to kick off the Fall. We were surrounded in the beer tent with lots of old friends such as the reigning King of Next Hop Model, Dan Gohr of Redemption Alewerks, and we met many new brew friends as the day charged on fueled by some incredible craft beer. In this episode at the Brewfest we are joined in segments by owner and brewer of Heady Hollow, Keefe Pietri, Grand Jucntion Brewing Co.’s Jon Knight and Shawn Kessel, Four Day Ray’s Brian Graham, Fuzic Media’s Brent Oakley, and a very tipsy Riley Wunnerenberg from our very own Pig Pen. We would like to thank Riley for running us samples all day as we worked the mics. A big thanks to Greg and Julia of The Noblesville Brewfest for inviting us to cover this wonderful, annual event. We are already looking forward to being there again next year. Special mentions to Metazoa, Redemption Alewerks, Flix Brewhouse, Scarlet Lane, and the Bier Brewery (we’re not gonna lie… we kinda missed Jerry) Tune in and make sure you don’t miss out next fall. We’ll see you there! Cheers!!

This episode picks up midstream at Metazoa Brewing Company after local musician, singer/songwriter, Robert Rolfe Feddersen, finished his last set and joined us for some more cold brews and hilarious, tipsy conversation.  Metazoa's own Haley Fennel was still hanging strong from our first show and still filling our bellies with delicious Metazoa brews.  Robert's beautiful wife, Terri Piet Feddersen, also jumped on a mic to round out this fun evening with new friends.  A high brew fueled conversation went in a number of different directions in this one from vinyl records, Cream, social media, the return of Dougy's glorious beard, and Pat's odd ability to hear audio warmth(which may have been the beer talking).  Some shout outs to DigIn~A Taste of Indiana, Beards Brewery, and Public House Cinema.  (And our apologies to PHC for being so loud during the outdoor movie.  The stupid sun went down a little too early.) Robert is more than just a talented musician, he is a gentleman with a big heart and a true lover and promoter of craft beer and music.   All music in this episode is of course provided by none other than Mr. Robert Feddersen.  Check out tonight's special episode and be sure to jump over to Robert's music page to find out where he'll be playing next.  We promise there will be craft beer! www.robertrolfefeddersen.com www.metazoa.beer www.publichousecinema.com  

If you listen to our show, you know we mention quite often that with all these new breweries opening, what seem like daily, they better be putting out a quality product if they want to have some staying power. We recently stepped into Metazoa which opened its doors just this past April and we were pleased to taste so many quality beers from such a young brewery. We spent a beautiful evening on their large outside seating area with Haley Fennell to fill us in on this young Indy brewery while live grooves were flowing indoors from the talented Robert Rolfe Feddersen. We had an array of great Metazoa brews while enjoying a great view of downtown Indianapolis as the sun went down. Metazoa is a big, bright, beautiful brewery that would fit in on any corner of San Diego, but we are pleased they have planted themselves in Indianapolis. Not only are they making some solid beers, this animal friendly brewery, is also giving back part of their profits to wildlife funding. Great view, pet friendly, live music, and good brew… what more do you need? Tune in and find out which were our favorite brews of the night and then get down to Metazoa to quench your thirst. Cheers!

Sponges are simple animals that mostly inhabit the marine ecosystem. The role of sponges in the marine ecosystem and the potential of their bioactive compounds for the pharmaceutical industry have already been reviewed. Because of the extensive investigations of sponges within those two disciplines, marine ecology and chemistry, sponges are among the best-studied Metazoa. Likewise, sponges have been selected as animal models for investigating the origin of the multicellularity because sponges have a simple body structure and physiology (e.g., lack of nervous and circulatory organs). Due to their diversity and abundance in the tropics, particularly in the Indo-Pacific, sponges have also attracted taxonomists, systematists and ecologists to assess their diverseness and their phylogenetic and phylogeographic relationships. Resolving those research questions is difficult, because sponges are categorised as comparatively character poor taxa. By using only conservative taxonomy or systematics, the sponge diversity might therefore be underestimated. Inevitably, sponge biologists have to employ molecular methods as additional tools. In this research, molecular tools were used in order to analyse the taxonomy, phylogeny and phylogeographic relationships of selected sponge species. Xestospongia testudinaria & Neopetrosia exigua (Family Petrosiidae, Order Haplosclerida) were selected because of their conspicuousness in the Indo-Pacific coral reef ecosystems, whereby Xestospongia testudinaria is prominently known as the Indo-Pacific giant barrel sponge. Additionally, the order Haplosclerida has been described as an example of sponge order that has been examined systematically for a number of years and displays major discrepancy between morphology and molecular phylogenies. Molecular data suggests that the order needs revision at all taxonomic levels, which is the cause for further conflicts between taxonomists and systematists. In my research I focused mostly on sponge samples that originated from South East Asia or the Indo-Australian Archipelago (IAA). This region represents one of the best-explored marine regions in the Indo-Pacific. The aim of my research is to discover to what extent molecular tools are suitable to detect a phylogenetic signal, a phylogeographical break or a genotypic difference in the two selected sponge taxa. Several markers from the mitochondrial (mtDNA), ribosomal (rRNA) and nuclear (nucDNA) have been utilised. The 3' partition of the cytochrome oxidase subunit 1 (I3-M11 of cox1) from the mtDNA could be used to detect a genetic structure in Xestospongia testudinaria in a geographical narrow scale study of < 200 km2 in Lembeh, North Sulawesi, Indonesia (Chapter 6) and throughout the Indo-Pacific despite limitations in the sample datasets (Chapter 2). In addition, the presence of a species complex in X. testudinaria was detected with the aid of phylogenetic reconstructions from a concatenation of mtDNA sequences (I3-M11 of cox1 and the Adenosine Triphosphate Synthase F0 subunit 6 / ATP6), and a nucDNA marker, the Adenosine Triphosphate Synthase β subunit intron (ATPS-β intron) (Chapter 6). At the same time, the presence of a species complex in X. testudinaria was recognised in a broader scale study of the Indo-Australian Archipleago (IAA) (Chapter 3). As a result, selected mtDNA and nucDNA markers in this thesis are useful for the investigation of the taxonomical status and phylogeographical relationships of X. testudinaria. A phylogeographical break in the IAA region due to the Pleistocene low sea level and Holocene recolonisation events (Chapter 3) could not be recovered among X. testudinaria in a phylogeographical analysis. Similarly, overlapping I3-M11 cox1 haplotypes between X. testudinaria, X. muta and X. bergquistia were recovered. This might be due to the presence of ancient polymorphisms on the barrel sponge mtDNA markers. Molecular tools are also used to help identifying my second selected sponge species (Chapter 4). The use of selected cox2 mtDNA and 28S rRNA markers contributed significantly to the identification of. Neopetrosia exigua used to be a congeneric of X. testudinaria. During my examinations of self-collected and holotype specimens I discovered that the species named N. exigua bears a wrong name. For this reason, a taxonomical revision is suggested and, more importantly, according to my findings and the principle of priority in the ICZN (International Code of Zoological Nomenclature) I use the species name ‘chaliniformis’ instead of the species name ‘exigua’. Furthermore, the use of selected nucDNA marker, the Lysidyl Aminoacyl Transfer RNA Synthetase (LTRS) intron, also contributes to the detection of phylogeographical breaks in N. chaliniformis of the IAA (Chapter 5). In a nutshell, the success of unravelling sponge taxonomies, phylogenies, and phylogeographic relationships always depends on the suitability of the utilised molecular markers and the significance of environmental influences on the sponges. Haplosclerid sponges possess limited morphological features. These hurdles create several problems, e.g. difficulties with taxa delimitation and unresolved phylogeography relationships. Even though the application of molecular techniques generated some limitations and obstacles in these studies, it has already contributed significantly to a better understanding of the phylogenies, phylogeographic relationships and taxonomical problems of X. testudinaria and N.chaliniformis, the species I selected for my research.

Landing in 1860s China, Rory - having spent time there once before - doesn't need the TeleTraveler to realize something is wrong. But it's difficult to figure out what that something is when the two time hoppers become separated and Jacob is taken by a woman with murderous tendencies. And even if Rory can get him back, they still have to find a way to prevent the downfall of the Ten Tigers of Canton. Otherwise, a legendary martial artist will be left fighting a losing battle...   "Ten Tigers" Cast:   Jacob Shattuck ...... DomVoice*   Rory Lenhardt ........ Taylor Carlson   Antagonist .............. Jim Brannen   Wong Fei-Hung ...... Ven Haydn*   Wong Kei-Ying ....... Edward Haynes Jr   Jing-Fei .................. Rachel Phillippe   Chon ...................... Joshua Paquette   Miss Ma ................. Amanda Gilbertson   Hon-Hei ................. Metazoa*   Other voice talents include:   Michelle Deco   Kasey Heimann   Brian Croft   Stuart O'Dwyer   * = Forum username/pseudonym

Receptor tyrosine kinases existed in the unicellular ancestors of multicellular animals and underwent diversification in the metazoan lineage.

Die autosomal dominante Optikusatrophie ist mit Mutationen in dem Gen OPA1 assoziiert. OPA1 kodiert eine konservierte mitochondriale Dynamin-ähnliche GTPase. Das Ortholog von OPA1 in S. cerevisiae ist Mgm1. Mgm1 liegt im Intermembranraum der Mitochondrien assoziiert mit der Innenmembran in zwei Proteinisoformen vor: der langen (l-Mgm1) und der kurzen Isoform (s-Mgm1). Beide Isoformen sind für den Erhalt der mitochondrialen Morphologie und der mitochondrialen DNA erforderlich. l-Mgm1 wird von der mitochondrialen Rhomboidprotease Pcp1 durch limitierte N-terminale Proteolyse in s-Mgm1 umgesetzt. OPA1 ist ebenfalls für den Erhalt normaler mitochondrialer Morphologie in Säugetierzellen erforderlich. Zusätzlich reguliert es die Freisetzung von Cytochrom c während der Apoptose. Insgesamt acht Transkriptionsvarianten von OPA1 sind bekannt, die durch alternatives Spleißen der N-terminal gelegenen Exons 4, 4b und 5b entstehen. Auf Proteinebene ließen sich bis zu fünf OPA1-Proteinisoformen unterschiedlicher Größe voneinander abgrenzen. Die Proteinisoformen liegen zum einen Teil membranverankert in der Innenmembran und zum anderen Teil peripher mit der Innenmembran assoziiert im Intermembranraum der Mitochondrien vor. Die vorliegende Dissertation beschäftigt sich mit der Biogenese der verschiedenen OPA1-Proteinisoformen. Hierzu wurden OPA1-Transkriptionsvarianten in Hefe heterolog exprimiert. OPA1 wird in Hefe ähnlich wie in Säugetierzellen prozessiert. Die Prozessierung erfolgt N-terminal, an mehreren Stellen und schrittweise. Die menschliche mitochondriale Rhomboidprotease PARL kann Pcp1 in der Hefe voll komplementieren, aber weder Pcp1 noch PARL prozessieren OPA1. In PARL-/--Mauszellen wird OPA1 normal prozessiert. In der Hefe ist die Prozessierung von OPA1 von den Untereinheiten Yta10 und Yta12 der mitochondrialen AAA-Protease der Matrix (m-AAA-Protease) abhängig. Durch Expression der Untereinheiten der menschlichen m-AAA-Protease, Paraplegin und AFG3L2, lässt sich die Prozessierung von OPA1 in yta10yta12 rekonstituieren. Die Ergebnisse deuten darauf hin, dass die Biogenese von Mgm1/OPA1 nicht vollständig von der Hefe bis zu Säugetieren konserviert ist. Der Austausch der prozessierenden Protease könnte in Verbindung mit einem Mechanismus zur Qualitätssicherung der Mitochondrien in Metazoa stehen.