Podcasts about Perturbation

durée : 00:14:32 - Journal de 7 h - Les deux évènements ont lieu cette semaine, hasard du calendrier, mais dans les deux cas il est question d'argent : hausse des salaires des cheminots et investissements dans les infrastructures, ferroviaires et routières.

durée : 00:14:32 - Journal de 7 h - Les deux évènements ont lieu cette semaine, hasard du calendrier, mais dans les deux cas il est question d'argent : hausse des salaires des cheminots et investissements dans les infrastructures, ferroviaires et routières.

Où acheter le livre ? Il est disponible sur Amazon au format papier et numérique : Lien Amazon - https://amzn.to/3OKImyU ------------------------------- Timeline et liste des sujets : 00:00:00 Introduction : Pourquoi cette traduction ? 00:01:40 Des traductions françaises falsifiées et scandaleuses. 00:05:15 Anglais et français, les deux langues les plus riches au monde. 00:08:19 Le gauchiste réécrit l'histoire. La vérité ne l'intéresse pas. 00:12:06 Lecture de ma préface. 00:34:10 Le gauchiste, ce faux rebelle qui ne prend aucun risque. 00:43:44 Jacques Ellul, le maître à penser de Theodore Kaczynski. 00:46:43 Perturbation du processus de pouvoir et aliénation. 00:50:04 Génie génétique et influence d'Aldous Huxley. 00:54:31 Destruction de la famille et de la communauté, au profit du système.

L'exploitant du métro de Paris s'est excusé mercredi après que des centaines de passagers sur plusieurs lignes ont été bloqués sous terre dans des températures étouffantes et en pleine heure de pointe.Traduction :The operator of the Paris metro system apologised on Wednesday after hundreds of passengers on multiple lines were blocked underground in stifling temperatures and at the height of rush hour. Hosted on Acast. See acast.com/privacy for more information.

L'exploitant du métro de Paris s'est excusé mercredi après que des centaines de passagers sur plusieurs lignes ont été bloqués sous terre dans des températures étouffantes et en pleine heure de pointe.Traduction :The operator of the Paris metro system apologised on Wednesday after hundreds of passengers on multiple lines were blocked underground in stifling temperatures and at the height of rush hour. Hosted on Acast. See acast.com/privacy for more information.

We're back with another dose of Nintendo news, game impressions and discussion! Join us as we discuss: Credits: Panelists: Hylke – @Gear12_Turbo Rosalie – @LilRecordGirl Edited by: Hylke Langhout Interludes: Craig Windle – @CraigedyCraig / Windmills at Dawn Music: Theme of Palworld– Tatsuya Yano (Palworld) Follow us: Gamepodular.com The post N-Focus #249 – Palworld Patent Perturbation appeared first on GAMEPODULAR.

We're back with another dose of Nintendo news, game impressions and discussion! Join us as we discuss: Credits: Panelists: Hylke – @Gear12_Turbo Rosalie – @LilRecordGirl Edited by: Hylke Langhout Interludes: Craig Windle – @CraigedyCraig / Windmills at Dawn Music: Theme of Palworld– Tatsuya Yano (Palworld) Follow us: Gamepodular.com The post N-Focus #249 – Palworld Patent Perturbation appeared first on GAMEPODULAR.

Vous ne savez pas dans quoi investir en Bourse ? Des gérants vous donne des idées de valeurs, secteurs, matières premières ...

Perturbation is what happens to people as they reach the edge of their comfort zone.  Are you or your organization experiencing perturbation and want help navigating? Take advantage of a complimentary business strategy session to discover the opportunities in your business! https://actioncoachwi.com/podcast-ask-a-question-complimentary-session/ 

This episode covers Orphan Black S2E8 "Variable and Full of Perturbation".If you have any questions or comments feel free to email us at onmylistpod650@gmail.com.

Join us in this week's episode by welcoming back Dr. Gretchen Hawley, PT, creator of the MSing Link. With her broad knowledge and specialization in MS, we will dive deeper into her research, recent findings, and more.  This week we focus on:  How vibration and perturbation training increases proprioception and reduces the risk of falls. More research updates on treating spasticity. Aerobic exercise and its benefits on supporting neuroplasticity. The impact of treating comorbidities to improve overall health and how that can also help with MS symptoms. Tune in now and learn more about MS and stay up-to-date on the latest research! You can find Dr. Gretchen's work and website at www.doctorgretchawley.com

durée : 00:02:27 - Un éleveur de Joué-sur-Erdre ne veut pas de perturbation au Salon de l'agriculture

Perturbation theory remains one of the main tools in physics, in particular in quantum theories. However, most perturbative series diverge factorially, and it is not obvious how to extract information from them. Their divergence also suggests that, in order to obtain accurate results, one might need additional non-perturbative information. The theory of resurgence has been proposed as a general framework to address these issues. In this talk I will give an introduction to this theory and will illustrate it with applications -old and new- in quantum mechanics, quantum field theory and string theory.

Il y a 5 ans, la mobilisation des Gilets jaunes traversait la France et la Belgique. Né sur internet et les ronds-points, le mouvement a rassemblé des centaines de milliers de personnes, durant près d'un an. « Colère noire, Gilet jaune », le slogan, témoigne d'une colère inédite face à la hausse du prix du carburant, à la vie chère et aux fins de mois difficiles. Perturbation de l'espace public, blocage des routes, utilisation de Facebook… Le mode d'action et de fonctionnement de ce mouvement protéiforme déconcerte. Et les journalistes ne sont pas en reste. Le saccage de l'Arc de Triomphe à Paris en décembre 2018 sera un choc immense, tout comme la violence policière et les blessures graves engendrées par l'usage des armes sublétales lors de ces épisodes de protestations. Que retenir du mouvement des Gilets jaunes ? Quelles étaient les revendications de ces manifestants d'un nouveau genre ? Et comment tout ceci a-t-il commencé ? Hélène Maquet et Bertrand Henne vous proposent un épisode foisonnant au cœur de la mobilisations des Gilets jaunes, en compagnie de leurs invités : Marc Zune, professeur de sociologie à l'UCLouvain et Arnaud Mercier, professeur en sciences de l'information et de la communication à l'université Paris-Panthéon-Assas. Réalisation : Jonathan Remy Merci pour votre écoute L'Histoire Continue c'est également en direct tous les samedis de 9h à 10h sur www.rtbf.be/lapremiere Retrouvez l'ensemble des épisodes de l'Histoire Continue sur notre plateforme Auvio.be https://auvio.rtbf.be/emission/l-histoire-continue-19690 Et si vous avez apprécié ce podcast, n'hésitez pas à nous donner des étoiles ou des commentaires, cela nous aide à le faire connaître plus largement.

Le changement climatique affecte notre planète de plusieurs façons. Voici quelques-uns des effets les plus importants: 1. Augmentation de la température: Le changement climatique provoque une augmentation de la température moyenne de la Terre. Cela entraîne des vagues de chaleur plus fréquentes et plus intenses, ce qui peut avoir des conséquences graves pour la santé humaine, les écosystèmes et l'agriculture. 2. Fonte des glaciers et des calottes glaciaires: En raison de l'augmentation des températures, les glaciers et les calottes glaciaires fondent à un rythme alarmant. Cela entraîne une augmentation du niveau de la mer, ce qui menace les zones côtières et les îles basses. 3. Perturbation des écosystèmes: Le changement climatique perturbe les écosystèmes naturels en modifiant les régimes de précipitations et en altérant les habitats des espèces. Cela peut entraîner la disparition d'espèces animales et végétales, ainsi que des perturbations dans les chaînes alimentaires. 4. Événements météorologiques extrêmes: Le changement climatique est responsable de l'augmentation de la fréquence et de l'intensité des événements météorologiques extrêmes tels que les ouragans, les tempêtes, les inondations et les sécheresses. Ces phénomènes peuvent causer des dégâts considérables aux infrastructures, à l'agriculture et aux communautés. 5. Acidification des océans: L'augmentation des émissions de dioxyde de carbone dans l'atmosphère entraîne une augmentation de l'acidité des océans. Cela a des conséquences néfastes sur les récifs coralliens, les coquillages et d'autres organismes marins sensibles à l'acidité. 6. Augmentation des maladies: Le changement climatique favorise la propagation de maladies transmises par les moustiques, les tiques et d'autres vecteurs. Les maladies telles que le paludisme, la dengue et la maladie de Lyme sont devenues plus prévalentes dans de nombreuses régions du monde en raison des conditions climatiques favorables à ces vecteurs. Il est important de noter que ces effets ne sont pas exhaustifs et que le changement climatique peut avoir d'autres conséquences sur notre planète. --- Send in a voice message: https://podcasters.spotify.com/pod/show/chatgpt20/message

Perturbation is anxiety and mental uneasiness caused by getting out of the comfort zone of our current beliefs and values. Growth isn't easy. Getting out of your comfort zone and past perturbation creates the opportunity to change the phases we are in, which creates growth.  Do you need courage and confidence to get to the next level? Take advantage of a complimentary business strategy session to discover the opportunities in your business! http://makemoreworkless.actioncoach.com/mmwl-diag-and-questions/ 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.20.549453v1?rss=1 Authors: Telerman, S. B., Hamilton, R. S., Shaw, B., Dimitrov, J. D., Steventon, B., Ferguson-Smith, A. C. Abstract: Perturbations in fundamental developmental pathways have a profound influence on tumorigenesis. Numb plays a pivotal role in vertebrate development, including neurogenesis and is a key negative regulator of Notch signaling. Perturbation of Numb expression affects brain morphology and cell fate. While extensive research has been conducted on canonical Notch ligands, regulation by vertebrate-specific non-canonical ligands is not understood. Here we identify Delta like non-canonical Notch ligand 2/EGFL9 (Dlk2) as a regulator of zebrafish neurogenesis with mutants exhibiting early increase and subsequent depletion of neural stem cells, decreased radial glial cells density, impaired neuronal cell distribution, and hypersensitivity to stimuli mimicking the embryonic murine Numb/Numblike null phenotype. Numb function is inactivated by aberrant phosphorylation, and we show that Dlk2 protein exhibits a high affinity direct interaction with Numb, with loss of Dlk2 in zebrafish telencephalon increasing Numb Ser276 phosphorylation with a concomitant increase in Notch signaling. Patients with tumors exhibiting reduced levels of Dlk2 have a poorer prognosis, while overexpression of Dlk2 in human cancer cell lines reduces cell proliferation. Our findings identify Dlk2 as a key partner of Numb, a gatekeeper of its activity, and an important player in a network of protein interactions regulating both neurogenesis and cancer with potential therapeutic implications. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.17.549269v1?rss=1 Authors: Dagnino, P. C., Escrichs, A., Lopez-Gonzalez, A., Gosseries, O., Annen, J., Sanz Perl, Y., L. Kringelbch, M., Laureys, S., Deco, G. Abstract: A fundamental challenge in neuroscience is accurately defining brain states and predicting how and where to perturb the brain to force a transition. The ability to promote a transition from one brain state to another by externally driven stimulation could significantly impact rehabilitation and treatments for patients suffering from complex brain injury cases. Thus, it is crucial to find therapeutic interventions able to re-balance the dynamics of brain disorders towards more healthy regimes. Here, we investigated resting-state fMRI data of patients suffering from disorders of consciousness (DoC) after coma (minimally conscious and unresponsive wakefulness states) and healthy controls. We applied model-free and model-based approaches to help elucidate the underlying brain mechanisms of patients with DoC. The model-free approach allowed us to characterize brain states in DoC and healthy controls as a probabilistic metastable substate (PMS) space. The PMS of each group was characterized by a repertoire of unique patterns (i.e., metastable substates) with different probabilities of occurrence. In the model-based approach, we adjusted the PMS of each DoC group to a causal whole-brain model. This allowed us to explore optimal strategies for promoting a transition to the PMS of the control group by applying off-line in silico probing. Furthermore, this approach enabled us to evaluate the impact of all possible local perturbations in terms of their global effects and sensitivity to stimulation, which is a biomarker providing a deeper understanding of the mechanisms underlying DoC. Our results show that transitions from DoC to more healthy regimes were obtained in a synchronous protocol, in which areas from the motor and subcortical networks were the most sensitive to perturbation. This motivates further work to continue understanding brain function and treatments of disorders of consciousness by external stimulation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.03.547526v1?rss=1 Authors: Kandemir, G., Wilhelm, S., Axmacher, N., Akyurek, E. Abstract: The neural mechanisms by which information is maintained in working memory are challenging to study, as such maintenance is not always correlated with detectable sustained neural activity. Perturbation of the memory network with a visual impulse has proven useful to probe memoranda in such activity-quiescent states. However, the impulse perturbation approach has so far been applied exclusively to spatially localized or spatially referenced stimuli, such as orientations or tone frequencies. It is unknown whether the neural maintenance mechanisms of non-spatial memoranda would be analogous. In the present study we therefore applied the impulse perturbation method to working memory for colours, which are intrinsically non-spatial stimuli, focusing on a set of pre-registered analyses. We analysed the EEG data of 30 participants who completed a delayed match-to-sample working memory task, in which one of the two items that were presented was retro-cued as task-relevant. We assessed the colour space underlying memory maintenance, and found that both cued and uncued colours were decodable from impulse-evoked activity, the latter in contrast to previous reports of working memory for orientation gratings. We furthermore examined colour decoding from ongoing oscillations in the alpha band, and found that cued items could be decoded therein, whereas uncued items could not, which might be mediated by attention. Overall, the outcomes suggest that subtle differences exist between the representation of colours and that of stimuli with spatial properties, but the present results also demonstrate that regardless of their specific neural state, both are accessible through visual impulse perturbation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

L'exploitant du métro de Paris s'est excusé mercredi après que des centaines de passagers sur plusieurs lignes ont été bloqués sous terre dans des températures étouffantes et en pleine heure de pointe.Traduction :The operator of the Paris metro system apologised on Wednesday after hundreds of passengers on multiple lines were blocked underground in stifling temperatures and at the height of rush hour. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

L'exploitant du métro de Paris s'est excusé mercredi après que des centaines de passagers sur plusieurs lignes ont été bloqués sous terre dans des températures étouffantes et en pleine heure de pointe. Traduction : The operator of the Paris metro system apologised on Wednesday after hundreds of passengers on multiple lines were blocked underground in stifling temperatures and at the height of rush hour. Learn more about your ad choices. Visit megaphone.fm/adchoices

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.22.546199v1?rss=1 Authors: Soetedjo, R., Horwitz, G. Abstract: Internal models are essential for the production of accurate movements. The accuracy of saccadic eye movements is thought to be mediated by an internal model of orbital mechanics encoded in the cerebellum. The cerebellum may also be part of a feedback loop that predicts the displacement of the eye in real time and compares the predicted displacement to the desired displacement command to ensure that saccades land on target. To investigate the role of the cerebellum in these two aspects of saccade production, we delivered saccade-triggered light pulses to channelrhodopsin-2-expressing Purkinje cells in the oculomotor vermis (OMV) of two macaque monkeys. Light pulses delivered during the acceleration phase slowed the deceleration phase of ipsiversive saccades. The long latency of these effects, and their scaling with light pulse duration, are consistent with an integration of neural signals downstream of the stimulation. In contrast, light pulses delivered during contraversive saccades reduced saccade velocity at a short latency (~6 ms) that was followed by a compensatory reacceleration which caused gaze to land near or on the target. We conclude that the contribution of the OMV to saccade control depends on saccade direction; the ipsilateral OMV is part of a forward model that predicts eye displacement, whereas the contralateral OMV is part of an inverse model that creates the force required to move the eyes accurately. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.03.539310v1?rss=1 Authors: Mayer, F. P., Stewart, A., Varman, D. R., Moritz, A. E., Foster, J. D., Owens, A. W., Areal, L. B., Gowrishankar, R., Velez, M., Wickham, K., Phelps, H., Katamish, R., Rabil, M. J., Jayanthi, L. D., Vaughan, R. A., Daws, L. C., Blakely, R., Ramamoorthy, S. Abstract: Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.23.537976v1?rss=1 Authors: Vranic-Peters, M. J., O'brien, P., Seneviratne, U., Reynolds, A., Lai, A., Grayden, D. B., Cook, M., Peterson, A. Abstract: Studying states and state transitions in the brain is challenging due to the nonlinear, complex dynamics present. In this research, we analyse the brain's response to non-invasive perturbations. Perturbation techniques offer a powerful method for studying complex dynamics, though their translation to human brain data is under-explored. This method involves applying small inputs, in this case via photic stimulation, to a system and measuring its response. Sensitivity to perturbations can forewarn a state transition, therefore biomarkers of the brain's perturbation response or 'cortical excitability' could be used to indicate seizure transitions. However, perturbing the brain often involves invasive intracranial surgeries or expensive equipment as in transcranial magnetic stimulation (TMS) which is only accessible to a minority of patient groups, or animal model studies. Photic stimulation is a widely used diagnostic technique in epilepsy that can be used as a non-invasive perturbation paradigm to probe brain dynamics during routine electroencephalography (EEG) studies in humans. This involves changing the frequency of strobing light, sometimes triggering a photo-paroxysmal response (PPR), which is an electrographic event that can be studied as a state transition to a seizure state. We investigate alterations in the response to these perturbations in patients with genetic generalised epilepsy (GGE), with (n=10) and without (n=10) PPR, and patients with psychogenic non-epileptic seizures (PNES; n=10), compared to resting controls (n=10). Metrics of EEG time-series data were evaluated as biomarkers of the perturbation response including variance, autocorrelation, and phase-based synchrony measures. We observed considerable differences in all group biomarker distributions during stimulation compared to controls. In particular, variance and autocorrelation demonstrated greater changes in epochs close to PPR transitions compared to earlier stimulation epochs. Comparison of PPR and spontaneous seizure morphology found them indistinguishable, suggesting PPR is a valid proxy for seizure dynamics. Also, as expected, posterior channels demonstrated the greatest change in synchrony measures, possibly reflecting underlying PPR pathophysiology mechanisms. We clearly demonstrate observable changes at a group level in cortical excitability in epilepsy patients as a response to perturbation in EEG data. Our work re-frames photic stimulation as a non-invasive perturbation paradigm capable of inducing measurable changes to brain dynamics. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.20.537688v1?rss=1 Authors: Vohryzek, J., Cabral, J., Perl, Y. S., Demirtas, M., Falcon, C., Gispert, D., Bosch, B., Balasa, M., Kringelbach, M. L., Sanchez, R., Ruffini, G., Deco, G. Abstract: One of the potential and promising adjuvant therapies for Alzheimer's disease is that of non-invasive transcranial neurostimulation to potentiate cognitive training interventions. Conceptually, this is achieved by driving brain dynamics towards an optimal state for an effective facilitation of cognitive training interventions. However, current neurostimulation protocols rely on experimental trial-and-error approaches that result in variability of symptom improvements and suboptimal progress. Here, we leveraged whole-brain computational modelling by assessing the regional susceptibility towards optimal brain dynamics from Alzheimer's disease. In practice, we followed the three-part concept of Dynamic Sensitivity Analysis by first understanding empirical differences between healthy controls and patients with mild cognitive impairment and mild dementia due to Alzheimer's Disease; secondly, by building computational models for all individuals in the mild cognitive impairment and mild dementia cohorts; and thirdly, by perturbing brain regions and assessing the impact on the recovery of brain dynamics to the healthy state (here defined in functional terms, summarised by a measure of metastability for the healthy group). By doing so, we show the importance of key regions, along the anterior-posterior medial line, in driving in-silico improvement of mild dementia and mild cognitive impairment groups. Moreover, this subset consists mainly of regions with high structural nodal degree. Overall, this in-silico perturbational approach could inform the design of stimulation strategies for re-establishing healthy brain dynamics, putatively facilitating effective cognitive interventions targeting the cognitive decline in Alzheimer's disease. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.05.535657v1?rss=1 Authors: Chen, Z., Xu, T., Liu, X., Becker, B., Li, W., Miao, K., Gong, Z., Zhang, R., Huo, Z., Hu, B., Tang, Y., Xiao, Z., Feng, Z., Chen, J., Feng, T. Abstract: Neurofunctional dysregulations in spatially discrete areas or isolated pathways have been suggested as neural markers for attention deficit hyperactivity disorder (ADHD). However, multiscale perspectives into the neurobiological underpins of ADHD spanning multiple biological systems remain sparse. This points to the need of multi-levels of analysis encompassing brain functional organization and its correlation with molecular and cell-specific transcriptional signatures are stressed. Here, we capitalized on diffusion mapping embedding model to derive the functional connectome gradient, and deployed multivariate partial least square (PLS) method to uncover the enrichment of neurotransmitomic, cellular and chromosomal connectome-transcriptional signatures of ADHD. Compared to typical control, ADHD children presented connectopic cortical perturbations in lateral orbito-frontal and superior temporal regions, which had also been validated in another independent sample. This gradient-derived variants in ADHD further aligned spatially with distributions of GABAA/BZ and 5-HT2A receptors and co-varied with genetic transcriptional expression. Cognitive decoding and gene-expression annotation showed the correlates of these variants in memory, emotional regulation and spatial attention. Moreover, the gradient-derived transcriptional signatures of ADHD exhibited enriched expression of oligodendrocyte precursors and endothelial cells, and were mainly involved as variants of chromosome 18, 19 and X. In conclusion, our findings bridged in-vivo neuroimging assessed functional brain organization patterns to a multi-level molecular pathway in ADHD, possibly shedding light on the interrelation of biological systems that may coalesce to the emergence of this disorder. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.22.533681v1?rss=1 Authors: Delgado, J. M., Shepard, L. W., Lamson, S. W., Liu, S. L., Shoemaker, C. J. Abstract: Lysosomal degradation of autophagy receptors is a common proxy for selective autophagy. However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, violate this assumption. Rather, BNIP3 and NIX are constitutively delivered to lysosomes in an autophagy-independent manner. This alternative lysosomal delivery of BNIP3 accounts for nearly all of its lysosome-mediated degradation, even upon mitophagy induction. To identify how BNIP3, a tail-anchored protein in the outer mitochondrial membrane, is delivered to lysosomes, we performed a genome-wide CRISPR screen for factors influencing BNIP3 flux. By this approach, we revealed both known modifiers of BNIP3 stability as well as a pronounced reliance on endolysosomal components, including the ER membrane protein complex (EMC). Importantly, the endolysosomal system regulates BNIP3 alongside, but independent of, the ubiquitin-proteosome system (UPS). Perturbation of either mechanism is sufficient to modulate BNIP3-associated mitophagy and affect underlying cellular physiology. In short, while BNIP3 can be cleared by parallel and partially compensatory quality control pathways, non-autophagic lysosomal degradation of BNIP3 is a strong post-translational modifier of BNIP3 function. More broadly, these data reveal an unanticipated connection between mitophagy and TA protein quality control, wherein the endolysosomal system provides a critical axis for regulating cellular metabolism. Moreover, these findings extend recent models for tail-anchored protein quality control and install endosomal trafficking and lysosomal degradation in the canon of pathways that ensure tight regulation of endogenous TA protein localization. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Perturbation Based Balance Training Want to make sure you stay on top of all things geriatrics? Go to http://PTonICE.com/resources to check out our Free eBooks, Lectures, & the MMOA Digest!  

Dr. Alex Germano // #GeriOnICE // www.ptonice.com 

Perturbation is the uncomfortableness that we must to go through to get to the next level. We can dread it or we can embrace it and reap the rewards at the other end. Listen as Mike and Jackie discuss the definition of perturbation and the reward it brings you when you get to the other side. In perturbation and want to reap the reward? Take advantage of a complimentary business strategy session to discover the opportunities in your business! http://makemoreworkless.actioncoach.com/mmwl-diag-and-questions/

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.01.530587v1?rss=1 Authors: Kandemir, G., Akyurek, E. Abstract: We investigated if learned associations between visual and auditory stimuli can afford full cross-modal access to working memory. Previous research using the impulse perturbation technique has shown that cross-modal access to working memory is one-sided; visual impulses reveal both auditory and visual memoranda, but auditory impulses do not seem to reveal visual memoranda (Wolff et al., 2020b). Our participants first learned to associate six auditory pure tones with six visual orientation gratings. Next, a delayed match-to-sample task for the orientations was completed, while EEG was recorded. Orientation memories were recalled either via their learned auditory counterpart, or were visually presented. We then decoded the orientation memories from the EEG responses to both auditory and visual impulses presented during the memory delay. Working memory content could always be decoded from visual impulses. Importantly, through recall of the learned associations, the auditory impulse also evoked a decodable response from the visual WM network, providing evidence for full cross-modal access. We also observed that after a brief initial dynamic period, the representational codes of the memory items generalized across time, as well as between perceptual maintenance and long-term recall conditions. Our results thus demonstrate that accessing learned associations in long-term memory provides a cross-modal pathway to working memory that seems to be based on a common coding scheme. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.05.527184v1?rss=1 Authors: Kinsky, N. R., Voroslakos, M., Lopez Ruiz, J. R., de Jong, L. W., Slager, N., McKenzie, S., Yoon, E., Diba, K. Abstract: Optogenetics are a powerful tool for testing how a neural circuit influences neural activity, cognition, and behavior. Accordingly, the number of studies employing optogenetic perturbation has grown exponentially over the last decade. However, recent studies have highlighted that the impact of optogenetic stimulation/silencing can vary depending on the construct used, the local microcircuit connectivity, extent/power of illumination, and neuron types perturbed. Despite these caveats, the majority of studies employ optogenetics without simultaneously recording neural activity in the circuit that is being perturbed. This dearth of simultaneously recorded neural data is due in part to technical difficulties in combining optogenetics and extracellular electrophysiology. The recent introduction of LED silicon probes, which feature independently controllable miniature LEDs embedded at several levels of each of multiple shanks of silicon probes, provides a tractable method for temporally and spatially precise interrogation of neural circuits. Here, we provide a protocol addressing how to perform chronic recordings using micro LED probes. This protocol provides a schematic for performing causal and reproducible interrogations of neural circuits and addresses all phases of the recording process: introduction of optogenetic construct, implantation of the micro LED probe, performing simultaneous optogenetics and electrophysiology in vivo, and post-processing of recorded data. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.30.525828v1?rss=1 Authors: Queiroz Zetune Villa Real, K., Mougios, N., Rehm, R., Sograte-Idrissi, S., Albert, L., Rahimi, A. M., Maidorn, M., Martinez-Carranza, M., Hosseini, H., Saal, K. A., Oleksiievets, N., Prigge, M., Tsukanov, R., Stenmark, P., Fornasiero, E. F., Opazo, F. Abstract: Imaging of living synapses has relied for over two decades on the overexpression of synaptic proteins fused to fluorescent reporters. This strategy changes the stoichiometry of synaptic components and ultimately affects synapse physiology. To overcome these limitations, here we introduce a nanobody that binds the calcium sensor synaptotagmin-1 (NbSyt1). This nanobody functions in living neurons as an intrabody (iNbSyt1) and is minimally invasive, leaving synaptic transmission almost unaffected, as demonstrated by the crystal structure of the NbSyt1 bound to synaptotagmin-1 and by our physiological data. Its single-domain nature enables the generation of protein-based fluorescent reporters, as we showcase here by measuring spatially-localized presynaptic Ca2+ with an NbSyt1- jGCaMP8 chimera. Moreover, its small size makes the NbSyt1 ideal for various super-resolution imaging methods. Overall, NbSyt1 is a versatile binder that will enable imaging in cellular and molecular neuroscience at a higher precision than possible in the past, over multiple spatiotemporal scales. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.27.525949v1?rss=1 Authors: Wang, T., Avraham, G., Tsay, J. S., Abram, S. J., Ivry, R. B. Abstract: Cerebellar-dependent implicit adaptation has been regarded as a rigid process that automatically operates in response to movement errors in order to keep the sensorimotor system calibrated. This hypothesis has been challenged by recent evidence suggesting flexibility in this learning process. One compelling line of evidence comes from work suggesting that this form of learning is context-dependent, with the rate of learning modulated by error history. Specifically, learning was attenuated in the presence of perturbations exhibiting high variance compared to when the perturbation is fixed. However, these findings are confounded by the fact that the adaptation system corrects for errors of different magnitudes in a non-linear manner, with the adaptive response increasing in a proportional manner to small errors and saturating to large errors. Through simulations, we show that this non-linear motor correction function is sufficient to explain the effect of perturbation variance without referring to an experience-dependent change in error sensitivity. Moreover, by controlling the distribution of errors experienced during training, we provide empirical evidence showing that there is no measurable effect of perturbation variance on implicit adaptation. As such, we argue that the evidence to date remains consistent with the rigidity assumption. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Actualités Locales : - L'homme qui avait commis une prise d'otage dans une banque au Havre en 2020 condamnée à 10 ans de prison- Perturbation sur le réseau SNCF les week-ends à partir du 28 janvier- Un nouveau skatepark à Montivilliers pour 2023- L'illustratrice havrais Marygribouille a mis en dessin l'ouvrage "SOS Grossesse"- Le navigateur Guillaume Pirouelle en stand-by avant le un départ pour la Route de la Découverte aux cotés de Thomas CovilleOn rend un hommage au musicien David Crosby décédé la semaine dernière.Bonne écoute !

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.22.521654v1?rss=1 Authors: Bansal, A. T., 't Hart, B. M., Cauchan, U., Eggert, T., Straube, A., Henriques, D. Abstract: People continuously adapt their movements to ever-changing circumstances, and particularly in skills training and rehabilitation, it is crucial that we understand how to optimize implicit adaptation in order for these processes to require as little conscious effort as possible. Although it is generally assumed that the way to do this is by introducing perturbations gradually, the literature is ambivalent on the effectiveness of this approach. Here we test whether there are differences in motor performance when adapting to an abrupt compared to a ramped visuomotor rotation. Using a within-subjects design, we test this question under 3 different rotation sizes: 30{degrees}, 45{degrees}, and 60{degrees}, as well as in 3 different populations: younger adults, older adults, and patients with mild cerebellar ataxia. We find no significant differences in either the behavioural outcomes, or model fits, between abrupt and gradual learning across any of the different conditions. Neither age, nor cerebellar ataxia had any significant effect on motor adaptation either. These findings together indicate that motor adaptation is not modulated by introducing a perturbation abruptly compared to gradually, and is also unaffected by age or mild cerebellar ataxia. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.09.519544v1?rss=1 Authors: Turk, S. M., Indovina, C. J., Overton, D. L., Runnebohm, A. M., Orchard, C. J., Doss, E. M., Richards, K. A., Irelan, C. B., Daraghmi, M. M., Bailey, C. G., Miller, J. M., Niekamp, J. M., Gosser, S. K., Tragesser-Tina, M. E., Claypool, K. P., Engle, S. M., Buchanan, B. W., Woodruff, K. A., Olesen, J. B., Smaldino, P. J., Rubenstein, E. M. Abstract: The relationship between lipid homeostasis and protein homeostasis (proteostasis) is complex and remains incompletely understood. We conducted a screen for genes required for efficient degradation of Deg1-Sec62, a model aberrant translocon-associated substrate of the endoplasmic reticulum (ER) ubiquitin ligase Hrd1, in Saccharomyces cerevisiae. This screen revealed that INO4 is required for efficient Deg1-Sec62 degradation. INO4 encodes one subunit of the Ino2/Ino4 heterodimeric transcription factor, which regulates expression of genes required for lipid biosynthesis. Deg1-Sec62 degradation was also impaired by mutation of genes encoding several enzymes mediating phospholipid and sterol biosynthesis. The degradation defect in ino4{Delta} yeast was rescued by supplementation with metabolites whose synthesis and uptake are mediated by Ino2/Ino4 targets. Stabilization of a panel of substrates of the Hrd1 and Doa10 ER ubiquitin ligases by INO4 deletion indicates ER protein quality control is generally sensitive to perturbed lipid homeostasis. Further, loss of INO4 sensitized yeast to proteotoxic stress, suggesting a broad requirement for lipid homeostasis in maintaining proteostasis. Abundance of the ER ubiquitin-conjugating enzyme Ubc7 was reduced in the absence of INO4, consistent with a model whereby perturbed lipid biosynthesis alters the abundance of critical protein quality control mediators, with broad consequences for ER proteostasis. A better understanding of the dynamic relationship between lipid homeostasis and proteostasis may lead to improved understanding and treatment of several human diseases associated with altered lipid biosynthesis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.30.518502v1?rss=1 Authors: Needs, H. I., Henley, J., Collinson, I. Abstract: Protein import into mitochondria is an intricate and highly conserved process essential for organellar biogenesis, and maintenance of its structure and function. Defects in the import apparatus impact the assembly of the respiratory chain and ATP synthase complexes required for oxidative phosphorylation, compromising the ready supply of ATP to the cell. The consequences of reduced bioenergetic function are particularly severe for cells with high energetic demands such as neurons. However, relatively little is known about howdefectiveimportcontributestoneurodegeneration, or how neurotoxic proteins characteristic ofneurodegenerative diseases impact mitochondrial import efficiency. Here, we used HeLa cells to investigate how expressing high levels of Tau variants affect mitochondrial import activity, morphology, and function. We found that the variant associated with neurodegeneration (TauP301L) colocalises with mitochondria. TauP301L, but not wildtype Tau, interacts with TOM40, the protein-channel component of the outer membrane protein import complex. Interestingly, TauP301L expression had no discernible effect on overall mitochondrial import function, despite associating with TOM40 and altering mitochondrial morphology, suggesting that a rescue mechanism is at play. This rescue could be explained by the appearance of microtubule and actin containing tunnelling nanotubes (TNTs), used to recruit healthy mitochondria from neighbouring cells and/or dispose of mitochondria with aggregated Tau. Furthermore, in primary neuronal cultures TauP301L induces morphological changes that resemble a neurodegeneration like phenotype, and this is mirrored in cells where the import sites are blocked artificially. These results reveal an intriguing link between the production of aggregation prone protein variants, such as Tau, and the mitochondrial protein import machinery relevant to neurodegenerative disease. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.29.518352v1?rss=1 Authors: Grotehans, N., McGarry, L., Nolte, H., Kroker, M., Narbona-Perez, A. J., Deshwal, S., Giavalisco, P., Langer, T., MacVicar, T. Abstract: Replication and expression of the mitochondrial genome depend on the sufficient supply of nucleotide building blocks to mitochondria. Dysregulated nucleotide metabolism is detrimental to mitochondrial genomes and can result in instability of mitochondrial DNA and inflammation. Here, we report that a mitochondrial nucleoside diphosphate kinase, NME6, supplies mitochondria with ribonucleotides to drive the transcription of mitochondrial genes. Moreover, NME6 supports the maintenance of mitochondrial DNA when the access to cytosolic deoxyribonucleotides is limited. Perturbation of NME6 leads to the depletion of mitochondrial transcripts, destabilisation of the electron transport chain and impaired oxidative phosphorylation; deficiencies which are suppressed upon supplementation with pyrimidine ribonucleotides. Our work proposes NME6 and mitochondrial nucleotide metabolism to be untapped therapeutic targets in diseases associated with aberrant mitochondrial gene expression including cancer and autoimmune disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

RSD measurements from BOSS galaxy power spectrum using the halo perturbation theory model by Byeonghee Yu et al. on Wednesday 30 November We present growth of structure constraints from the cosmological analysis of the power spectrum multipoles of SDSS-III BOSS DR12 galaxies. We use the galaxy power spectrum model of Hand et al. (2017), which decomposes the galaxies into halo mass bins, each of which is modeled separately using the relations between halo biases and halo mass. The model combines Eulerian perturbation theory and halo model calibrated on $N$-body simulations to model the halo clustering. In this work, we also generate the covariance matrix by combining the analytic disconnected part with the empirical connected part: we smooth the connected component by selecting a few principal components and show that it achieves good agreement with the mock covariance. We find tight constraints on $fsigma_8$: $fsigma_8(z_{mathrm{eff}}=0.38)=0.489 pm 0.036$ and $fsigma_8(z_{mathrm{eff}}=0.61)=0.455 pm 0.026$ at $k_{mathrm{max}} = 0.2 h$Mpc$^{-1}$, in good agreement with Planck amplitude. This corresponds to $S_8 = 0.821 pm 0.037$ or an overall amplitude error of 4%, within 0.3 sigma of Planck's $S_8 = 0.832 pm 0.013$. We discuss the sensitivity of cosmological parameter estimation to the choice of scale cuts, covariance matrix, and the inclusion of hexadecapole $P_4(k)$. We show that with $k_{mathrm{max}} = 0.4 h$Mpc$^{-1}$ the constraints improve considerably to an overall 2.7% amplitude error (with $S_8 = 0.786 pm 0.021$), but there is some evidence of model misspecification on MultiDark-PATCHY mocks. Choosing $k_{mathrm{max}}$ consistently and reliably remains the main challenge of RSD analysis methods. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.16794v1

RSD measurements from BOSS galaxy power spectrum using the halo perturbation theory model by Byeonghee Yu et al. on Wednesday 30 November We present growth of structure constraints from the cosmological analysis of the power spectrum multipoles of SDSS-III BOSS DR12 galaxies. We use the galaxy power spectrum model of Hand et al. (2017), which decomposes the galaxies into halo mass bins, each of which is modeled separately using the relations between halo biases and halo mass. The model combines Eulerian perturbation theory and halo model calibrated on $N$-body simulations to model the halo clustering. In this work, we also generate the covariance matrix by combining the analytic disconnected part with the empirical connected part: we smooth the connected component by selecting a few principal components and show that it achieves good agreement with the mock covariance. We find tight constraints on $fsigma_8$: $fsigma_8(z_{mathrm{eff}}=0.38)=0.489 pm 0.036$ and $fsigma_8(z_{mathrm{eff}}=0.61)=0.455 pm 0.026$ at $k_{mathrm{max}} = 0.2 h$Mpc$^{-1}$, in good agreement with Planck amplitude. This corresponds to $S_8 = 0.821 pm 0.037$ or an overall amplitude error of 4%, within 0.3 sigma of Planck's $S_8 = 0.832 pm 0.013$. We discuss the sensitivity of cosmological parameter estimation to the choice of scale cuts, covariance matrix, and the inclusion of hexadecapole $P_4(k)$. We show that with $k_{mathrm{max}} = 0.4 h$Mpc$^{-1}$ the constraints improve considerably to an overall 2.7% amplitude error (with $S_8 = 0.786 pm 0.021$), but there is some evidence of model misspecification on MultiDark-PATCHY mocks. Choosing $k_{mathrm{max}}$ consistently and reliably remains the main challenge of RSD analysis methods. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.16794v1

Perturbation - The In Between Your Best Life with Barbie Layton As Seen in USA Today, Forbes, Goss, and other media outlets, Barbie is an International Best You Expo speaker going from side to the Main stage in 6 months in 2020 based on fan feedback and 25 years of previous speaking engagements to four New York Times Square Billboard! She has a global TV channel on The Best You TV called “You Are Amazing!” where she interviews world thought leaders who are changing the world for the positive! She earned an M.A In Spiritual Psychology from the world famous University of Santa Monica and participated in the Cannes film festival winning documentary as a counselor to women serving life sentences in Chowchilla, California on “The Prison Project” , based on Viktor Frankl's work in 2007. She is a 2021 graduate of Vishen Lakhiani's Premium Coaching. She helps CEO's and individuals alike reanimate their dreams, fall in love with themselves, and become the VIP of their own lives with powerful one of a kind intuitive Soulprint energy clearings that have manifested miracles in her clients' lives. She has been featured in USA Today, Forbes, and many other international media outlets and she is in the second edition of the international bestselling book “Women Gone Wild”, that launched in June and is #1 in 9 categories. She was a speaker at the Can You Really Think and Grow Rich? World Tour sponsored by the Napoleon Hill Foundation. She will also be featured in Dr. John De Martini's documentary called “Breakthrough”, will be in Ignite Publishing's “Ignite Humanity” book and the upcoming MindValley Heroes book series, and will be the next cover girl of LiT magazine in September was a featured speaker at The Love Event, will be speaking at Secret Knock Women's event June 2023. Connect with Barbie https://www.barbielayton.com https://www.facebook.com/barbie.layton.5 —————————— Join Xpansion Alchemy the divine alchemy school for all souls looking to transform and Xpand - https://xpansionalchemy.com/ Web - http://aniahalama.com/ Facebook - https://www.facebook.com/xpansionalchemy Instagram - https://www.instagram.com/xpansion_alchemy/ TikTok - https://www.instagram.com/xpansion_alchemy/ Xpansion Alchemy Community - https://www.facebook.com/groups/xpansionalchemy —————————— Book a 1:1 Virtual Coffee to see how I can help you - https://bit.ly/1-1VirtualCoffee —————————— You can purchase my bestselling book 'Rebel's Guide to Spirituality' here - http://rebelsguidetospirituality.com/ —————————— Join Abundance Vortex and become an abundant badass overflowing with infinite manifestation power - https://aniahalama.com/abundance-vortex —————————— Follow me on social! Web - http://aniahalama.com/ Facebook - https://www.facebook.com/ania.e.halama/ Instagram - https://www.instagram.com/aniatravels/ Youtube - https://www.youtube.com/c/AniaTravels Spiritual BA Babes Community - https://www.facebook.com/groups/spiritualityforbadassbabes/ —————————— Shop Organifi and use code AniaTravels at checkout. https://greendropship.com/ Get seen in front of 500K Women - https://bit.ly/WHWE --- Support this podcast: https://podcasters.spotify.com/pod/show/spiritualityforbadassbabe/support

durée : 00:04:08 - Le monde d'après - par : Jean Marc FOUR - Sergei Choïgu, le ministre de la défense russe, l'a affirmé ce week-end, menaçant à toutes les capitales occidentales : Selon lui Kiev serait en train de développer une "bombe sale".

durée : 00:04:08 - Le monde d'après - par : Jean Marc FOUR - Sergei Choïgu, le ministre de la défense russe, l'a affirmé ce week-end, menaçant à toutes les capitales occidentales : Selon lui Kiev serait en train de développer une "bombe sale".

The heroes are in trouble when an undead artiste is hellbent on using their skin as a canvas. Will they escape with their lives, or will this artisan ghoul complete his masterpiece? *** If you enjoy the show, please leave us a rating and review at the podcast service of your choice, and find our social links at www.tabletopgold.com. Tabletop Gold is Lars Casteen, David Chernicoff, Zoe Chernicoff, R. Matt Humphreys, and Robin Lange. The Roots of Ruin is a production of the Pathfinder Adventure Path Abomination Vaults for Pathfinder Second Edition. Licensed music by Nicolas Jeudy / Dark Fantasy Studio and GameDev Market. Original music by Lars Casteen. The Roots of Ruin is a Tabletop Gold production, produced under the Paizo Incorporated Community Use policy.  The Roots of Ruin uses trademarks and/or copyrights owned by Paizo Inc., used under Paizo's Community Use Policy (paizo.com/communityuse).  We are expressly prohibited from charging you to use or access this content.  Paizo does not recognize, endorse, or sponsor this project in any way.  Original characters and content are the property of Tabletop Gold.  For more information about Paizo Inc. and Paizo products, visit paizo.com…

Welcome to Another One: An Orphan Black Podcast. In this episode, we discuss the eighth episode of season two: Variable and Full of Perturbation. Twitter: @RTOPodcasts, @ThatCoolBlkNerd, @Scarfinger, @Rashanii Become a Patron at http://www.Patreon.com/singlesimulcast Donate to the show at http://www.buymeacoffee.com/sscast Promos: @PCast_Ol

Welcome to Another One: An Orphan Black Podcast. In this episode, we discuss the eighth episode of season two: Variable and Full of Perturbation. Twitter: @RTOPodcasts, @ThatCoolBlkNerd, @Scarfinger, @Rashanii Become a Patron at http://www.Patreon.com/singlesimulcast Donate to the show at http://www.buymeacoffee.com/sscast Promos: @PCast_Ol

Welcome to Another One: An Orphan Black Podcast. In this episode, we discuss the eighth episode of season two: Variable and Full of Perturbation. Twitter: @RTOPodcasts, @ThatCoolBlkNerd, @Scarfinger, @Rashanii Become a Patron at http://www.Patreon.com/singlesimulcast Donate to the show at http://www.buymeacoffee.com/sscast Promos: @PCast_Ol --- Send in a voice message: https://anchor.fm/hsmr/message

Scientists brought to life a project about the orbit to the moon and what can cause to brave cosmonaut We are a NON-PROFIT Podcast Https://icreepypastas.co.uk e-mail us at info@icreepypastas.co.uk You can send us a Story or More written by you or For Legal issues and we will transfer you by phone to our legal department. Don't Forget to like, comment, share and subscribe See podvine.com/privacy-policy for privacy and opt-out information.

The difference between disruption and change, and how they relate