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In diesem Gespräch geht es um die Herausforderungen und Strategien für Selbstständige, insbesondere im Bereich Webdesign. Jonas Arleth teilt seine Erfahrungen und gibt Ratschläge, wie man den richtigen Zeitpunkt für die Selbstständigkeit findet, finanzielle Sicherheit aufbaut und harte Entscheidungen trifft, um erfolgreich zu sein. Er betont die Bedeutung eines finanziellen Puffers und die Fähigkeit, Nein zu sagen, um sich auf die richtigen Projekte zu konzentrieren. --------------------------------------------- Meine Onlinekurse:
On this episode Tim and Tanner discuss taking some time off. Tanner gets into the Puffers on the east Coast and Tim gets the Grouper and big mangroves on the west. Bonus reflections on old episodes, Cichlids on the Univerisity of Miami Campus.
ANZ is one step closer to acquiring Suncorp for $4.9 billion, after a court overturned the ACCC's decision to reject the acquisition. Star Entertainment's shares have dropped 22% after a second inquiry into the Sydney Star Casino. The company behind Rip Curl and Kathmandu has seen its shares hit an all-time low after warm weather has hurts their sales. — Build the financial wellbeing of your team with Flux at Work: https://bit.ly/fluxatwork Download the free app (App Store): http://bit.ly/FluxAppStore Download the free app (Google Play): http://bit.ly/FluxappGooglePlay Daily newsletter: https://bit.ly/fluxnewsletter Flux on Instagram: http://bit.ly/fluxinsta Flux on TikTok: https://www.tiktok.com/@flux.finance —- The content in this podcast reflects the views and opinions of the hosts, and is intended for personal and not commercial use. We do not represent or endorse the accuracy or reliability of any opinion, statement or other information provided or distributed in these episodes.See omnystudio.com/listener for privacy information.
Around here, northern puffers are mostly known as an accidental curiosity: a fish occasionally caught when you're looking for something else, and — unlike any other fish — it blows up like a balloon. But don't throw it back that quick! They're also tasty.
All eyes turn to Eagle Farm for the G1 QLD Derby and the G1 Kingsford Smith Cup. We also preview programs from Sandown, Randwick and Muzza B in this weeks SULT'S SPECS. Hot baths with lots of salt and Turkish bread are celebrated at this weeks SULTANS SUPPER. We also applaud the performance of one of our very best hoops on the rise and Knollsy from West Ham, the ultimate muscle. PACK YA NAGS takes a look at some Sultsy scheduling and Footy takes aim at the Fire Brigade. Stretch hummers and Uber Eats notifications are also put on notice. Our UNIT OF THE WEEK charity partner for Season 5 is Racing Hearts (https://www.racinghearts.com.au). Money raised throughout Season 5 will go towards providing equine and animal assisted counselling, psychology and educational programs for those most in need in the community. Funds will also assist Racing Hearts to retrain and rehome retired racehorses. Thanks to TopSport for the ongoing support with this. As always we round out the show with our 2 UNITS, our best bets from around Australia. Segment Times: 01:48 - The Sultan's Supper 08:30 - Pack Ya Nags 15:39 - Sults' Specs 36:15 - UNIT of the Week 36:30 - 2 UNITS Outro: The Cardigans - Lovefool Imagine what you could be buying instead. For free and confidential support call 1800 858 858 or visit gamblinghelponline.org.au
EATING PUFFERS - POND LADY & PRE-SPAWN BASS 310 Pre Spawn Bass w Les “The Professor” Cline Interview with Greg -Knitting Daddy about catching cooking and eating puffer fish Amie The Oklahoma Pond Lady vs the IG expert
Peacoats, puffers and hoodies. Question of the day. Save your clothes and save money! When does old age start? World's largest Buc-ee's is coming to Texas! What gets you in the holiday spirit? Women dress for other women. Taylor Swift ticket drama. Food news. This day in history. Entertainment news. Coors nail polish.
Christian Brando, actor and son of Marlon Brando had a more than fascinating life. Champ Clark interviewed and recorded the actor, and after he died, transformed the tapes into a one-man play that is nothing short or captivating and enthralling. Jon Mese captures this man, and just owns this performance! Before they embark on an international run, they are stopping at Puffers of Pismo this Sunday to share this one-man production that you will not forget. Check out their chat here!
Christian Brando, actor and son of Marlon Brando had a more than fascinating life. Champ Clark interviewed and recorded the actor, and after he died, transformed the tapes into a one-man play that is nothing short or captivating and enthralling. Jon Mese captures this man, and just owns this performance! Before they embark on an international run, they are stopping at Puffers of Pismo this Sunday to share this one-man production that you will not forget. Check out their chat here!
Are you one of the five million people with asthma in the UK? If so, could you be on a different inhaler - one that could control your asthma better while also being kinder to the planet? “Puffers” - or aerosol spray inhalers - contain potent greenhouse gases and can be tricky to use correctly, so not everyone can control their asthma. We speak to Caroline from Cornwall, who has switched inhalers and it's transformed her life. James talks to the doctors who think far more people could benefit from making the change. We also speak to Nerys from North Wales who has started antiviral treatment for her Covid infection. We explore the new drugs with virologist Dr Elisabetta Groppelli and Prof Chris Butler who is running the clinical trial designed to pinpoint who is likely to benefit from antivirals the most. PRESENTER: James Gallagher PRODUCER: Beth Eastwood
Starting this week, top sustainable fashion brand Frank And Oak's customers can take advantage of the best Black Friday savings on the outerwear collection and winter coats for extreme cold weather. The collection includes puffer jackets with hoods and https://ca.frankandoak.com/pages/womens-sustainable-winter-outerwear (waterproof puffer jackets for women).
(Starts at 1:12 mark) Four candidates are in the running for Chief of Qalipu First Nation in the October 14-22 elections. We hear, in no particular order, from (2:15) Corner Brook's Geoff Sparkes, (4:09) Peggy White of the Three Rivers Mi'kmaw Band in Robinson's, (7:31) Odelle Pike of the Stephenville area, and (10:49) current Qalipu Chief Brendan Mitchell of Corner Brook. (15:07) The family of Her Majesty's Penitentiary inmate Gregory Pike, who recently died by suicide, protested in St. John's against the lack of addiction- and mental-health treatment at HMP. (17:37) Joanne Power of Gander travelled to the protest to support her incarcerated son, who she says needs counselling, too. (22:37) A company called Breathe Suite is introducing a new device and smartphone app, to help people who have asthma and COPD make the most of their medication, and (32:05) Author Susan Flanagan joins us to talk about her brand-new novel, "The Degrees of Barley Lick."
Inspired by origami, A-Puffer's lightweight design is capable of flattening itself, tucking in its wheels, and crawling into places rovers can't fit.
The world of jellyfish, puffers at the Scottish Maritime Museum and the joy of parkrun
Im Interview habe ich diesmal Janine Kohnen, Architektin Dipl. – Ing. und Podcasterin, zu Gast. Wir sprechen über ihre Erfahrungen und Tipps, damit du bei deinem Architekten-Erstgespräch genau weißt, worauf du achten musst. Du erfährst in dieser Folge unter anderem: Was du beim Erstgespräch mit einem Architekten erwarten kannst Wie du den für dich passenden Architekten erkennst Welche Details du für dein Erstgespräch bereits kennen solltest Wie ein realistischer Zeitplan für ein Projekt aussieht Ob es Sinn macht, als Bauherr schon einen Grundriss vorzubereiten Warum du im besten Fall bereits ein Grundstück haben solltest Was Janine dir bezüglich eines Puffers für dein Vorhaben empfiehlt Du möchtest mehr über meinen Interviewgast erfahren? Du findest Janine hier: Linkedin Profil von Janine Kohnen: Instagram: die_kittybob Facebook: diekittybob; Unter dem Link www.marcofehr.ch findest du weitere Blogartikel und Podcastfolgen.
The liberal networks competed furiously to get the first interview with "1619 Project" creator Nikole Hannah-Jones as she showily spurned a tenure offer from her alma mater. CBS's Gayle King won the puffery contest.
In today's episode of Reefs and Reptiles, we will be talking about Pea Puffers. Pea Puffers are amazing little freshwater fish that can be a very rewarding pet. While these puffers exhibit many of the same traits as a saltwater pufferfish, they come in a very manageable size and they stay in freshwater their entire lives. This makes water changes much easier! Pea Puffers have a lot to offer and if you don't know about them or having been thinking about getting them this episode is for you.
Sometimes the most compelling locations on a planet's surface are extreme landscapes that can be challenging for astronauts to investigate.
The Nine of Cups tarot is a card of accomplishment and satisfaction. In a reading, the Nine of Cups also suggests the fulfillment of wishes. Some people are put off but the man's smug expression in the Nine of Cups and the way displays the symbols of his success. Just look at all those trophy cups. But a closer look will tell you that he has earned his bragging rights. SPIRIT ANIMAL MEANINGS Puffer Fish, also called Blowfish or Toadfish, has a very visible and clever means for self-protection. They inflate their body with air or water, so they look more threatening. As a benefit, it extends the Puffers' thorns, making an impressive impact on would-be predators. There is symbolism here about using our body language as one means of avoiding difficult and potentially dangerous situations. What do the adorable Puffer Fish and the Nine of Cups have in store for your Monday pick a card tarot reading? Watch the video to find out! 0:00-1:26 Intro 1:27-1:55 Puffer Fish Spirit Animal Meanings 1:56-2:01 Planetary Influence 2:02-2:04 Red Root Maladhara Chakra Correspondence 2:05-7:55 Nine of Cups Rider Waite Tarot Meanings 7:56-14:12 Puffer Fish Spirit Animal Meanings Buy your Ark Animal Tarot & Oracle Deck now! https://whatismyspiritanimal.com/product/the-ark-animal-tarot-oracle-deck/ Join the Wild Pack on our forums: https://GatheringofMystics.com/ Puffer Fish Mandala Video: https://youtu.be/B91tozyQs9M Book a reading with Bernadette: https://whatismyspiritanimal.com/product/shamanic-spirit-animal-reading/ The Difference Between Spirit, Totem, and Power Animals: https://youtu.be/wM1JXDwCZ7s Sign Up for the Daily Tarot Card Reading Email List: https://mailchi.mp/whatismyspiritanimal.com/daily-reading-sign-up More about Nine of Cups: https://www.buildingbeautifulsouls.com/tarot-card-meanings/minor-arcana/suit-cups/nine-of-cups-tarot/ https://whatismyspiritanimal.com What Is My Spirit Animal is dedicated to helping people connect with and learn from their animal spirit guides. What Is My Spirit Animal can show you how to find your spirit animal, understand your totem animal, and tap into the energy of your power animal. Try our spirit animal meditation and take our spirit animal quiz! Find hundreds of spirit animal meanings as well as your Native American Zodiac Sign! *Disclaimer* By reading, watching, and consuming (in any way) content (videos, readings, lives, et all) originating from Building Beautiful Souls, Inc. its holdings and/or agents (WhatisMySpiritAnimal.com, BuildingBeautifulSouls.com, WitchesandWitchcraft.com, GatheringofMystics.com, WildPackWisdom.com) you agree all material contained therein is metaphysical and spiritual in nature and for entertainment purposes only. #PickaCard #DailyTarotReading #SpiritAnimal
Vi svarar på dina stilfrågor! Vår bucket list, perfekta puffers, smyckesförvaring, nya boken + MYCKET MER! See acast.com/privacy for privacy and opt-out information.
Zoals dit jaar ons wel heeft geleerd: het leven loopt niet altijd zoals je had gepland. In deze derde aflevering stellen we helaas geen nieuwe co-host aan je voor, maar bespreken we wel alles over coving season. Want wat kan je doen met je dateleven in deze winterlockdown? We geven je tips om te daten in een gedeeltelijke lockdown, vragen ons af of thermo-ondergoed sexy is, drinken ons favoriete warme date-drankje en adviseren deze winter koselig door te brengen. Last but not least: exclusieve haiku's van de Enterman.
On this episode, we get in the Thanksgiving spirit! Jordan recounts eating three massive meals over the weekend, Pat tells an awkward gambling story from his time in Vegas and Matt loads up another hot take after getting roasted for his Applebee's take. From there, the boys review the Capiche [Vessel], Get Up off of that Thang [Devil May Care] and Don't Worry Bee Happy [Bee Boyz] (00:00 - 38:49). From there, we move on to this week's Wet Bread Rocket Ship, where we discuss what we loved and hated from the past week in Wrestling (38:49 - 1:04:30) Finally, the boys review Cyber Sunday 08, where Matt takes us back to the BBM days and Pat comes to realize that he can record the podcast from the Bathroom if need be. (1:04:30 - 1:56:19) #Drinklocal #Emergencypuffers
Buckle up, Strange Crew! We got one hell of an amazing guest today, a woman we have been wanting on the show since inception, an incredible friend and die-hard music lover, Shelley Brown!
In this episode Leo talks about his trip to Saco river, fixing your sack as a man, vegan deodorant, girls having it way harder than guys, dolphins using pufferfish to get high, and the Butt Kicker of the Week featuring Mother Teresa.Thanks so much for tuning in!!!Don’t forget to LIKE, SHARE, and SUBSCRIBE!!SUPPORT BLM MOVEMENT: https://blacklivesmatters.carrd.co/You can find all of Leo's Information at:www.loagranted.com*Are all of your dreams granted?*
Chris and Kristie return for #GCBS semi final week, and it's pie time for our intrepid bakers. They discuss cultish wombats, the joy of a rough puff pastry, while lamenting one baker's week from hell at the worst possible time.
On this episode we talk about whistleblowers and the Trump Impeachment. Why is it that this CIA whistleblower is a hero, but Snowden is not? Watch this Snowden interview: https://www.youtube.com/watch?v=PArFP7ZJrtg We also talk about the FDA’s plans to ban vaping. Tyranny.
In het noorden van Nederland woedde de afgelopen jaren een strijd. Tussen de laarsjes en de raketjes. En de 148 andere soorten inhalators die er bestaan voor astmapatiënten. Het gevolg: dokters die niet meer weten wat ze moeten voorschrijven en patiënten die niet weten hoe ze een medicijn moeten gebruiken. Vandaag een verhaal over schurende belangen van artsen, apothekers en farmaceuten. En de patiënt die daar tussenin zit.Presentatie: Thomas RuebGast: Karel BerkhoutProductie: Henk Ruigrok van der WervenMontage: Jan Paul de Bondt
In this episode, we did the second part of pulmonary physiology for this summer. We covered pulmonary function tests (PFTs/spirometry), obstructive lung disease (asthma, COPD), restrictive lung disease, and more. Enjoy! Welcome to Physiology by Physeo (an InsideTheBoards podcast)! This show brings together some of the best boards-relevant content for physiology and pathophysiology from three innovative platforms: Physeo, InsideTheBoards, and Med School Phys. Having gone through the grind of med school ourselves, we understand the fast-paced lifestyle you're living right now, so our aim is to help the listener learn while on-the-go. By listening to our show, you'll be one step closer to slaying the USMLE. Discounted Physeo Subscription for InsideTheBoards listeners Head over to Physeo's Website and sign up for a subscription. Use the code ITB25 to receive 25% off your subscription. Keep calm and watch Physeo. InsideTheBoards Study Smarter Series for the USMLE Step 1 and COMLEX Level 1 Check out the ITB Study Smarter Series Podcast channel. We're covering high yield practice questions to help you study on the go during your dedicated USMLE Step 1 prep time. Go to bit.ly/ITBpodcasts or just click here to check it out on iTunes. ITB Audio Qbank and iOS Beta App The ITB iOS app is here. It includes all our podcasts (with exclusive and expanded content), early access to podcasts we'll be releasing in the future, some meditations designed specifically for medical students and intended for use during your dedicated USMLE prep time (gotta keep those stress levels down, right?), plus the beta version of our all audio qbank. There's a sample of high yield audio questions for each version, and of course you can purchase a subscription to help us finish the full scale, Android and iOS app, which will have tons more features. It's not perfect. But it is THE PERFECT companion for studying for the boards on the go. And we're adding content and improving it all the time. Search the App Store for "InsideTheBoards" or click here to download it now. Android user? Until we release the cross-platform version of the app this summer, you can still subscribe to the podcast version of ITB's All-Audio Qbank by clicking here. The #listenlearnlive Contest ("We'll Pay For Yours Boards" thanks to Physicianloans.com) We're giving away all kinds of prizes in exchange for your help promoting all of InsideTheBoards' podcasts. You earn entries by completing certain actions like sharing or reviewing our podcasts. But you probably know that ITB is all about promoting the wellbeing of medical students. So we also want to push the hashtag #listenlearnlive. The "live" part of this represents our interest in not just your scores, but also your lives outside of medicine. Hence, you can also earn entries just for doing healthy things like exercising, walking your dog, spending time with your fam, or listening to music and then snapping a photo, tagging us, and using the hashtag #listenlearnlive in a social media post. It's actually three separate, month-long contests running now through July. The Top Three winners at the end of each month's contest will be placed into a drawing for the Grand Prize: your USMLE Step 1/Step 2 or COMLEX Level 1/Level 2 Registration Fee (thanks to the generosity of Physicianloans.com )That's a prize worth over $600. We're also giving away things like subscriptions to our All-Audio Qbank. Just go to bit.ly/paymyusmle to sign up. Legal Stuff InsideTheBoards and Physeo are not affiliated with the NBME, USMLE, COMLEX, NBOME or any professional licensing body. InsideTheBoards fully adheres to the policies on irregular conduct outlined by the aforementioned credentialing bodies. All information, content, and materials published by this podcast are for informational purposes only and are NOT intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified healthcare provider. Please consult your healthcare provider regarding personal medical decisions.
Alistair Braidwood from the Podcast SCOTS WHAY HAE! chats to Pat about catering, travelling, steam fired puffers and the writer James Kelman Jim & Pat's Glasgow West End Chat - Episode 31 SCOTS WHAY HAE! Pat's Guide to Glasgow West End Twitter: @glasgowswestend Music by Jim Byrne Photo by Jim Byrne
5/11/18 Interview with Democratic gubernatorial candidate Shri Thanedar. High percentage of local ballot proposals approved by voters. State school chief Brian Whiston dies. Legislature debates whether to rubber-stamp recreational marijuana initiative, or let it go on fall ballot. Republican candidates for governor, including Bill Schuette for first time, debate in Grand Rapids. Sponsored by www.Deadline Detroit.com.
Once our podcast here is complete, we will peer inward and discover the truth. Thanks for joining us this week as we talk about Metroid Prime. A severe turn from the appearance of previous Metroid games, Prime retains a lot of the DNA that makes up the series it belongs to, despite the shift in perspective. Because of these similarities, design appears to have been focused around making a traditional Metroid game play well in first person and were generally successful enough that the game has maintained a following over the fifteen years since its release. We discuss controls, loneliness in aesthetic and admiring those beautiful, stupid ass Puffers. Thanks for checking us out again this week, and come back next time for our conversation on Severed!
Dois animais fofos procuram salvar um valentão de um destino trágico! Olá! Essa Mesa Predestinada é bem fofa. Nela, dois Strays, animais que procuram enfrentar coisas más e inspirar crianças ao bem, no caso o Esperto Hamster Samwise e a Fofa e Durona Gatinha Marie, procuram impedir que um valentão seja capturado por uma criatura maligna, o Homem do Saco. Para isso, ele tem que sair da Lista dos Malvados do Velho Nick (o Papai Noel) antes de uma determinada data. Será que o tempo será o bastante? E como eles farão isso, se animais não falam com humanos, mesmo aqueles muito espertos e capazes de ler humano? Strays é um cenário family-friendly para Fate Acelerado onde animais fofos, que já foram animais de estimação, enfrentam o mal e procuram impedir criaturas más de fazerem maldades. Além disso, devem inspirar crianças e outras criaturas boas a serem cada vez mais corajosas e gentis. Desculpem pelas falhas de áudio na captura e pela tosse de ambos. :-( Nosso contato para esse podcast é o email mesaspredestinadas@gmail.com, entre outros contatos a serem estipulados. Link para o programa em MP3 Participantes: Fábio Emilio Costa (Narrador e Samwise) William de Mello Otomo (Marie) Duração: 178min Cronologia do Podcast: 00:00:10 - Apresentação básica do Cenário e dos Personagens 00:04:31 - Marie recebe a missão de ir à Cidade, tendo que encarar algo bem mal-cheiroso no processo 00:10:33 - Marie chega à Praça da Cidade,mas no processo arruma confusão com ratos maus 00:20:03 - Marie encontra Samwise, que a livra da enrascada com os ratos, com seu conhecimento sobre coisas humanas 00:29:59 - Marie e Samwise encontram Joffrey, o mensageiro, e ele passa a missão aos dois 00:39:37 - “Todos tem a fagulha para o Bem e para o Mal” - Joffrey conta sobre a história do Puffers 00:51:30 - Samwise e Marie procuram ver os meninos envolvidos, e ajudam os meninos a fugir 01:11:21 - Marie resgata Samwise das mãos de Rodrigo e foge do cachorro do mesmo, Lancaster 01:17:10 - Marie e Samwise encontram Govinda, e tentam convencê-lo a ajudar os dois 01:17:10 - Marie e Samwise encontram Govinda, e tentam convencê-lo a ajudar os dois 01:27:54 - Marie e Samwise fazem Govinda ser adotado por Raistlin, e nesse processo descobrem uma pista importante sobre o Velho do Saco 01:44:35 - Samwise fica com muito sono, e Marie decide ir agir sozinha, procurando por Lancaster e encontrando um gambá sedutor 01:54:50 - Marie encontra a casa de Lancaster e descobre o que levou Rodrigo a ser malvado… 01:54:50 - Marie encontra a casa de Lancaster e descobre o que levou Rodrigo a ser malvado… 02:10:12 - O Velho do Saco faz sua primeira vítima… Mas os Strays não sabem… 02:17:10 - Samwise e Marie estão tão exaustos que dormem o dia inteiro, mas Govinda comenta que Lancaster os garotos 02:24:23 - Govinda faz alguns comentários que Marie e Samwise aprovam e definem planos para salvar Rodrigo 02:26:59 - Govinda pede para voltar para casa, e outro grito lancinante revela: o Velho do Saco fez uma segunda vítima 02:28:53 - O Dia de Ação de Graças chega… É a calma antes de tempestade 02:31:37 - Govinda conta um boato sobre os desaparecimentos e Raistlin e Helena 02:33:22 - Os garotos maus chegam na casa de Raistlin e Helena para fazerem arruaça! 02:41:54 - O Velho do Saco sai das sombras… E Marie tenta convencer que Rodrigo não está pronto! 02:54:55 - A Conclusão da Aventura! Links Relacionados: Strays (Pague o quanto quiser) Ficha da Marie Ficha do Samwise Ficha do Puffers (NPC) Fichas para Impressão A Aventura mestrada A Mesa em vídeo Link para a comunidade do Google+ do Mesas Predestinadas Comente esse post no site do Mesas Predestinadas! Assine no iTunes Trilha Sonora do Podcast: Hide And Seek por Shane Ivers BEES! por Shane Ivers Clowning Around por Shane Ivers Chicken Hut Bluegrass por Shane Ivers Walk Happy por Shane Ivers Spark of Inspiration por Shane Ivers
Nesse episódio especial de Aniversário de 1 ano do Fate Masters, quem recebe o presente é você, ouvinte: uma dúvida de um dos nosssos ouvintes nos inspirou a abrir uma nova série, a partir do tema Façanhas. Falaremos aqui de Façanhas, como usá-las, o que são, como considerar equilíbrio, façanhas mais amplas que o normal (encontradas em Nest), Façanhas levemente mais poderosas (encontradas em Young Centurions), mega-façanhas de Atomic Robo e outros tópicos similares. Além disso, o Doutor fifo está de volta, por meio das Provocações do Doutor Fifo, que nesse episódio questiona: Que variações interessantes você vê ao usar Façanhas Condicionais? Ouça no podcast a provocação do Doutor Fifo, pense na mesma e comente sobre suas idéias! Lembrem-se: qualquer dúvidas, críticas, sugestões e opiniões você pode enviar na comunidade do Google+ do Fate Masters, na comunidade do Facebook do Fate (com as hashtags #fatemasters e #doutorfifo), e pelo email fatemasterspodcast@gmail.com Link para o programa em MP3 Participantes: Fábio Emilio Costa Rafael Sant’Anna Meyer Paulo Guerche Filipe Dalmatti Lima (nas Provocações do Doutor Fifo) Duração: 47min Cronologia do Podcast: 00:05 - Apresentação 03:23 - Definindo Façanhas 05:58 - Estruturando uma Façanha e exemplo de Façanha de Exceção à Regra 12:25 - Exemplos de Façanha de Bônus e Façanhas de Manipulação de Cenário 16:12 - Equilibrando Façanhas, Façanhas e Tom do Cenário, Façanhas Amplas de Nest, Façanhas Poderosas de Daring Comics e Façanhas Centuriãs de Young Centurions 25:00 - Mega-Façanhas do Atomic Robo 34:25 - Sobre o ajuste de nível na Criação de Cenário 39:44 - A Estréia das Provocações do Doutor Fifo (sobre Façanhas Condicionais) 46:35 - Considerações Finais Links Relacionados: Puffers - personagem exemplo citado pelo Mr. Mickey Nicola Castrogiovanni - personagem exemplo citado pelo Mr. Mickey Post na comunidade do Google+ do Luiz Carlos Júnior que foi a base desse podcast Nest Gods & Monsters Nest Strays Young Centurions Daring Comics SRD do Atomic Robo, incluindo as regras de Mega-Façanhas (em inglês) Episódio de Criação do Cenário Caçadores da Alvorada (Dawn Hunters) Atomic Robo, em Inglês Link para a comunidade do Google+ do Fate Masters Comente esse post no site do Fate Masters! Assine no iTunes Trilha Sonora do Podcast: Ambient Pills por Zeropage Ambient Pills Update por Zeropage
Nesse episódio do Rolando +4, Fábio, Jean e Alex continuam sua série sobre Narrativa Compartilhada, falando sobre os Aspectos em uma aventura e campanha de Fate, suas diferenças, usos, e como aproveitar eles para uma narrativa compartilhada com o objetivo de todos terem o melhor em termos de aventura Link para o programa em MP3 Participantes: Alex Resende Fábio Emilio Costa Jean da Silva Duração: 53min Cronologia do Podcast: 00:15 - Apresentações 01:38 - Definindo Aspectos 04:02 - Aspectos de Personagem 07:53 - Aspectos de Cena/Situação/Cenário 10:22 - Impulsos 13:44 - Consequências (e Condições do Ferramentas do Sistema (System Toolkit)) 19:39 - Duração dos Aspectos (o quanto os Aspectos permanecem em jogo) 28:10 - “Aspectos, enquanto em jogo, SÃO VERDADES NO JOGO!” 31:07 - Aspectos são ambíguos 34:22 - Nomeando os Aspectos de maneira adequada 40:10 - Renomeando Aspectos (e porquê às vezes é melhor deixar em branco) 45:20 - Aspectos e Evolução de Personagem 51:35 - Considerações Finais Links Relacionados: Fichas dos Personagens de La Vaporeta (Hendrika, Rosa e Alfonso) Gods and Monsters Nest Psychedemia Part-Time Gods Atomic Robo RPG Atomic Robo (Web-comic) Kannin Dragon espancando Jiraya no estilo - um uso positivo de uma Dificuldade Guia do Rob para criação de Bons Aspectos Strays Fate System Toolkit (onde são mencionadas as Condições - em inglês) Puffers - personagem para Strays citado no podcast (em Inglês) Link para a comunidade do Google+ do Rolando +4 Comente esse post no site do Rolando +4! Assine no iTunes
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 02/07
Das Ziel der vorliegenden Arbeit war es, herauszufinden in wieweit die Therapie einer metabolischen Azidose bei Durchfallkälbern durch die orale Verabreichung von Natriumbikarbonat per Kälberschlundsonde möglich ist und ob der Pansensaft-pH-Wert Einfluss auf die Resorption des in den Pansen eingegebenen Puffers hat. Es sollte festgestellt werden, ob es eine bestimmte für alle Kälber mit einer gering- bis mittelgradigen metabolischen Azidose geltende Menge an Natriumbikarbonat gibt, die oral verabreicht in der Lage ist diese Durchfallkälber zu therapieren, ohne dass Nebenwirkungen des Natriumbikarbonats auftreten. Das Patientengut bestand aus 32 bis zu vier Wochen alten Kälbern, die infolge eines Durchfallgeschehens eine metabolische Azidose aufwiesen. 50 g Natriumbikarbonat oral verabreicht war eine Puffermenge, die den Blut-pH-Wert und den BE-Wert der Kälber zumindest vorübergehend ausgeglichen hat, ohne dass deutliche Nebenwirkungen auftraten. Bei einigen Tieren dieser Untersuchung mussten weitere Pufferbehandlungen durchgeführt werden. Es gibt aber keinen eindeutigen Befund, der bereits im Voraus die Vermutung zulässt, welche Tiere eine weitere Pufferbehandlung benötigen. Bei Kälbern, die nach der Behandlung eine gute Tränkeaufnahme zeigen, ist eine ausreichende Wirkung der einmaligen Pufferbehandlung anzunehmen. Ein Einfluss des Pansensaft-pH-Wertes auf die Resorption des Natriumbikarbonats im Pansen konnte nicht festgestellt werden.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 02/19
Zusammenfassung Einleitung Mikrosphären (MS) gelten als Standardmethode zur Messung des regionalen Blutflusses. Hierzu werden MS linksatrial injiziert. Sie verteilen sich dann im arteriellen Teil des Blutkreislaufes. Die Anzahl der in den präkapillären Gefäßen festgehaltenen MS ist direkt proportional der regionalen Organdurchblutung. Da die bisherige Markierung der MS mit instabilen Nukliden die Nachteile des Umgangs mit Radioaktivität mit sich brachte, hat man in den letzten Jahren versucht, die MS mit Fluoreszenzfarbstoffen (FM) zu beladen. Diese neue Art der Markierung erfordert allerdings, daß die FM quantitativ aus den Organproben zurückgewonnen werden müssen. Dies geschah bisher mittels Filtration oder Sedimentation. Beide Methoden bieten jedoch Nachteile. Ziel unserer Studie war es, eine neue Methode zu entwickeln und deren Verarbeitungsprozess zu automatisieren. Dazu wurde ein Filtrationsgefäß entwickelt, das die Probenverarbeitung (Gewichtsbestimmung, Verdauung, Filtration, Spülung und Farbstoffauslösung) in einem einzigen Gefäß zuläßt und hierbei die vollständige Rückgewinnung der FM aus der Organprobe sicherstellt. Material und Methodik: Die von uns am Institut für Chirurgische Forschung entwickelte Sample Processing Unit (SPU) – gebrauchsmustergeschützt - besteht aus drei Untereinheiten: Filterhalter, Filter und Probengefäß. Der essentielle Bestandteil der SPU ist der Filter, der mit einem Polyamid-Filtergewebe (Maschenöffnung 7µm) ausgestattet ist. Das von uns entwickelte Verarbeitungsprotokoll sieht folgende Schritte vor: Die Gewebeprobe wird in den Filter gelegt und das Probengewicht bestimmt. Der Filter wird dann in ein Edelstahlkochgefäß gestellt und zur Verdauung des Gewebes werden 15 ml Digestionsflüssigkeit (4N KOH mit 0,02% Tween) und 1,5 ml Isopropanol 100% hinzugegeben. Nach 6 Stunden Inkubation bei 60°C ist das organische Material vollständig aufgelöst und die FM schwimmen in der Zwischenschicht zwischen KOH und Isopropanol. Mit Hilfe von Unterdruck wird die Flüssigkeit durch das Filtergewebe filtriert. Dadurch kommen die FM auf der Membran zu liegen. Der später von den FM ausgelöste Fluoreszenzfarbstoff benötigt ein neutrales Umgebungsmilieu. Hierzu müssen alle KOH-Rückstände aus dem Filter entfernt werden. Dies geschieht mittels eines Phosphatpuffers (29.9g K2HPO4 in 800ml aqua dest. vermischt mit 5.88g KH2PO4 in 200ml aqua dest.), der auf einen neutralen pH-Wert eingestellt ist. Mit 15 ml dieses Puffers wird die gesamte Innenfläche des Filters abgespült. Durch kurzes Eintauchen des Filters in den Puffer wird auch die Außenfläche von den KOH-Resten befreit. Nach Trocknung des Filters durch Zentrifugation (4000 U/min für 4 min) wird der Farbstoff mit 2 ml eines organischen Lösungsmittels (2-Ethoxyethyl acetat - Cellosolve) aus den FM ausgelöst. Durch erneute Zentrifugation (4000 U/min für 4 min) wird der Farbstoff im Sammelgefäß aufgefangen und die Fluoreszenzintensität in einem Fluoreszenzspektrometer (LS50B, Perkin Elmer, Überlingen, Deutschland) bestimmt. Die Konzentration des Farbstoffes läßt auf die Anzahl der FM rückschließen, welche wiederum direkt proportional zum Blutfluß in der untersuchten Gewebeprobe ist. Der Proportionalitätsfaktor wird durch eine Blutreferenzprobe bestimmt, die während der Injektion der FM aus der Aorta thoracalis unter konstanter Pumpenzuggeschwindigkeit (Harvard Pump, Harvard Apparatus South Nattick, USA) entnommen wird. Diese Blutprobe kann ohne vorherige Verdauung unter Koagulationsschutz (CPDA mit dem Hauptbestandteil Citrat) direkt filtriert werden. Der Farbstoff wird mittels Cellosolve aus den Mikrosphären ausgelöst und die Fluoreszenzintesität bestimmt. Experimente Zunächst wurden die FM und die SPU in vitro Tests unterzogen. Bei den FM wurde mit Hilfe einer Verdünnungsreihe die Proportionalität zwischen der Anzahl der FM und der Fluoreszenzintensität untersucht. Die SPU und die dazugehörige Verarbeitungsmethode wurden einer Wiederfindungsstudie unterzogen. Dabei wurde dieselbe Anzahl von FM aller Farben in Filter und Glasröhrchen pipettiert. Die Filter durchliefen den gesamten Verarbeitungsprozeß. Das Filtrat und die Wände der Filter wurden auf die Präsenz von FM hin kontrolliert. Die Farbstofflösung, welche aus den 40 Filtern gewonnen wurde, wurde mit einer Referenzgruppe (Glasröhrchen ohne Probenverarbeitung, n=20) verglichen. Zur in vivo Validierung der SPU erfolgten an narkotisierten Schweinen (n=8) sechs simultane Injektionen von radioaktiv markierten 15µm MS (RM) (Niob, Strontium, Scandium, Indium, Cerium und Chrom) und 15µm FM (blue, bluegreen, yellowgreen, orange, red, scarlet) zu verschiedenen Zeitpunkten. Nach der Entnahme von Leber und Nieren, wurden diese Organe nach einem vorgegebenen Schema disseziert. Der regionale Blutfluß wurde anhand der Protokolle sowohl für RM (SCHOSSER et al. 1979) als auch FM bestimmt. Zunächst wurde die Radioaktivität der Proben im g-Counter (Canberra Packard, Frankfurt a.M., Deutschland) ermittelt. Hierauf wurde nach Verarbeitung der Organgewebe in der SPU die Fluoreszenzintensität mit Hilfe des Fluoreszenzspektrometers gemessen. Der Vergleich mittels beider Methoden erhobener Meßwerte wurde mit dem Bland-Altman-Plot durchgeführt. Hierbei wird das arithmetische Mittel der Blutflüsse, die durch FM- und RM-Methode berechnet worden sind, gegen die prozentuale Abweichung der FM von den RM aufgetragen. Zur Kontrolle der Filterfunktion und der Zuverläßigkeit der Meßergebnisse wurde die gleiche Anzahl (ca. 2500 FM) einer nicht im Experiment verwendeten 15 µm FM-Spezies (crimson), sowohl in SPU-Filter (SPU-Gruppe, n = 60), als auch in 20 Glasgefäße (Referenzgruppe, n = 20) gegeben. Die SPU wurden dem gesamten Protokoll der Probenverarbeitung unterzogen, wohingegen in der Referenzgruppe lediglich der Farbstoff ausgelöst und gemessen wurde. Die Gruppen wurden mittels t-test nach Student, p0,98). Die Filter weisen eine Wiederfindungsrate von 100% auf. Im Eluat fanden sich keine 15µm FM; zwischen der Filtergruppe und der Referenzgruppe besteht kein signifikanter Unterschied in der Fluoreszenzintensität. Es zeigt sich eine sehr gute Vergleichbarkeit beider Methoden. In den Bland-Altman Plots für die Nieren- und Leberproben wichen die Blutflußwerte mit der FM-Methode um 8,2 bis 13,4% vom mittleren Fluß (arithmetisches Mittel aus RM und FM) ab. Dabei betrug die mittlere Differenz beider Methoden zwischen -7,4% und 3,8%. Der Vergleich der mittleren Intensitäten der Kontrollfarbe crimson zwischen der Referenzgruppe (9,32±0,74, n=20) und der SPU- Gruppe (9,38±0,98, n=60) ergab keinen signifikanten Unterschied. Diskussion und Schlußfolgerung Mit der SPU ist es möglich, FM vollständig aus Organproben zurückzugewinnen und dadurch den regionalen Blutfluß quantitativ zu bestimmen. Die errechneten Blutflusswerte der radioaktiven und fluoreszierenden Methoden sind miteinander vergleichbar. Somit stellen die FM eine valide Alternative zu RM unter Vermeidung der Problematik des Umgangs mit Radioaktivität dar. Der entscheidende Vorteil der SPU ist, daß der gesamte Verarbeitungsprozeß im selben Gefäß stattfindet, und so der Verlust von FM nahezu ausgeschlossen ist.Das standardisierte Protokoll der Probenverarbeitung mittels SPU vermindert im Vergleich zu früheren Protokollen die Bearbeitungszeit von ca. 24h bzw. 48h auf ca. 6h und reduziert die Arbeitsschritte bei denen große Präzision gefordert ist. Das Design der SPU ermöglicht eine Automatisierung der Probenverarbeitung und somit eine Arbeitserleichterung, da die Von-Hand-Bearbeitung nur noch auf das Befüllen der SPU reduziert wird