Podcasts about dgk

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Best podcasts about dgk

Latest podcast episodes about dgk

KardioBeat – Der Kardio Podcast
Mentoring in der Kardiologie

KardioBeat – Der Kardio Podcast

Play Episode Listen Later Feb 6, 2025 37:47


In der 22. Folge des Kardio-Podcasts spricht Prof. Dr. David Duncker mit Prof. Dr. Carolin Lerchenmüller über die Bedeutung von Mentoring in der Kardiologie. Sie teilen ihre persönlichen Erfahrungen und geben Tipps, wie das Mentoring für beide Seiten bereichernd sein kann.

The Nine Club With Chris Roberts
#349 - Josh Kalis

The Nine Club With Chris Roberts

Play Episode Listen Later Dec 2, 2024 200:59


Josh Kalis discusses moving back to Michigan, why his Dad didn't like skateboarding, skating Love Park for the first time, Jamie Thomas hooking him up with Invisible Skateboards then Toy Machine, filming for his Toy Machine "Heavy Metal" part, going to EMB for the first time, almost skated for Real Skateboards but got on Alien Workshop instead, the DC Super Tour, run skate chill, why he left Alien Workshop, getting ownership in DGK, building his indoor park and much more! Timestamps 00:00:00 Josh Kalis 00:00:35 Living back in Michigan 00:10:19 Why didn't his dad like skateboarding 00:13:14 Moved to Dallas 00:14:17 Getting boards from Renegade / Shine Skateboards 00:16:17 His H-Street "Lick" part 00:18:00 Fighting the football team 00:24:49 Getting put into a crisis prevention center 00:27:50 Skating Love Park for the first time 00:37:48 Ricky Oyola saying "don't shoot those Dirty Ghetto Kids" 00:40:34 Ricky Oyola's and Josh's beef 00:46:28 Jamie Thomas hooking him up with "Invisible" then "Toy Machine" 00:56:44 His Toy Machine Heavy Metal part 01:01:09 Going to EMB for the first time 01:03:34 He was devastated that Mike Carroll moved out of SF & picked a new favorite skater 01:05:51 Moving to SF 01:12:20 Almost skated for Real but got on Alien Workshop 01:21:09 His process for filming videos parts back in the day 01:31:07 Love Park Philly days 01:41:30 Ken Block selling DC's out of his trunk 01:42:01 The DC Super Tour 01:49:10 Run Skate Chill 02:02:58 The Sabotage crew 02:07:47 Philly kids brought the Lynx back 02:20:22 Kalis in Mono video part 02:25:21 Felt like he lost his voice at Alien Workshop 02:27:20 Talked to Appleyard about starting a company 02:30:41 Getting ownership in DGK 02:42:10 Why Josh can't stand Olympics, SLS, etc. 02:47:58 His indoor park Learn more about your ad choices. Visit megaphone.fm/adchoices

The Nine Club With Chris Roberts
#344 - Dane Vaughn

The Nine Club With Chris Roberts

Play Episode Listen Later Oct 28, 2024 130:35


Dane Vaughn discusses growing up in Baton Rouge Louisiana, getting hit by a van when he was a kid, getting in trouble & being sent to a boys camp for troubled teens, moving to Texas & skating with Auby Taylor, getting a pro shoe with Supra, turning pro for DGK, working on some new video parts, Straye Footwear and much more! Timestamps 00:00:00 Dane Vaughn 00:08:52 Growing up in Baton Rouge, Louisiana, moving to Florida & getting hit by a van 00:14:44 Moving to Minnesota - joins a boxing gym at 9 years old 00:20:15 How he found skateboarding 00:34:18 First getting flowed product 00:36:58 Getting in trouble & being sent to a boys camp 00:40:14 Moving to Texas - skating with Auby Taylor 00:48:59 The moment things fell into place - moving to California 00:55:30 Anthony Shultz 01:01:00 Mag Minute & other video parts 01:07:11 DGK's The Playground 01:10:23 Zero/DGK tour 01:12:51 Going on DC trip to Canada and customs wouldn't let him into the country 01:20:51 Getting a pro shoe with Supra 01:25:16 First pro board & trying to approach skateboarding more professionally now 01:40:35 Dane's new board out now 01:42:28 What's he working on now - new video parts - art & hanging with Danny Minnick 01:48:40 La Graw part 01:56:34 Straye Footwear Learn more about your ad choices. Visit megaphone.fm/adchoices

History of the Bay
History of the Bay: Al Freshko

History of the Bay

Play Episode Listen Later Jun 13, 2024 51:38


Al Freshko is a graphic designer, graffiti writer, and skater who's created logos for world-famous brands, including his own. Born in the Philippines and moving to San Francisco, Al became entrenched in the booming street skateboarding scene of the Embarcadero and joined graffiti crews like ICP and FSC. After going to art school, he started designing album covers, skate decks and logos. Al's resume includes brands like Diamond, DGK, and Cookies; and he's worked with rappers like Wiz Khalifa, Mac Dre, and San Quinn. He collaborated on the brand "Freshko" with Wiz and Berner, and continues pushing his own Elemonkey brand through an innovative, invite-only system. -- Sponsored by Stem Social https://stemsocial.io https://instagram.com/stem.social Also sponsored by Lost Soul Courier Collective - call or text (415) 275-1922 for free Narcan delivery in San Francisco https://lostsoulcouriercollective.org For more info contact @traceyh415 -- For promo opportunities on the podcast, e-mail: historyofthebaypodcast@gmail.com -- Produced by DEO @deo415, videography by @mvp_kingced --- History of the Bay Spotify Playlist: https://open.spotify.com/playlist/3ZUM4rCv6xfNbvB4r8TVWU?si=9218659b5f4b43aa Online Store: https://dregsone.myshopify.com Follow Dregs One: Spotify: https://open.spotify.com/artist/1UNuCcJlRb8ImMc5haZHXF?si=poJT0BYUS-qCfpEzAX7mlA Instagram: https://instagram.com/dregs_one TikTok: https://tiktok.com/@dregs_one Twitter: https://twitter.com/dregs_one Facebook: https://facebook.com/dregsone415 --- Support this podcast: https://podcasters.spotify.com/pod/show/historyofthebay/support

The Nine Club With Chris Roberts
Rodrigo TX Back On DGK, Tyshawn II, Vinicius Costa | Nine Club Live #56

The Nine Club With Chris Roberts

Play Episode Listen Later Jun 7, 2024 189:15


Happy 8th Birthday Nine Club, Skateboarding Hall of Fame Induction and Inductees, Adidas Tyshawn II, What is the pathway to pro for Kids these days, SoleTech is sold! What does it mean, Vincius Costa Pocket Part, OSki Red Shark Part, Rodrigo TX Back on DGK, Dumb Data World Skate Study, Jenkem Tracks down Steve Rocco and much more! Timestamps 00:02:00 Happy 8th Birthday Nine Club and Thank Yous! 00:10:00 Superchat Giveaway Reminder 00:11:44 Skateboarding Hall of Fame Induction and Inductees 00:20:30 Skateboarding Hall of Fame Inductee Criteria, How you get in? 00:23:00 Adidas Tyshawn II 00:33:00 What is the pathway to pro for Kids these days? 00:37:00 Sole Tech is sold! What does it mean? Kelly's perspective 00:56:50 Vincius Costa Pocket Part 01:06:00 New Merch Drop 01:11:00 OSki Red Shark Part 01:24:33 Rodrigo TX Back on DGK 01:38:00 Dumb Data World Skate Study 02:13:00 Shoe Companies and impacts? 02:22:00 Jenkem Tracks down Steve Rocco 02:29:00 New Nine Club Product 2 02:32:00 Braden Hoban Rewatch 02:38:00 SOTY Board 02:47:00 Mendocino farms 02:53:00 Winding down, Peep Cordano's Thrasher XXXL Skater 02:56:00 SuperChat Drawing Learn more about your ad choices. Visit megaphone.fm/adchoices

Right Hand Drive Guys
JUN IMAI / KAIDO HOUSE - EP.76

Right Hand Drive Guys

Play Episode Play 34 sec Highlight Listen Later May 25, 2024 44:41 Transcription Available


Send us a Text Message.In this episode we sit down with Jun Imai the mind beind the Kaido House brand. We talk die cast, DGK collabs, GTRs in Japan and more. Socials @RHDGUYSMerch http://RHDGUYS.COMHow to Start a Podcast Guide: The Complete GuideLearn how to plan, record, and launch your podcast with this illustrated guide. David C Barnett Small Business and Deal Making M&A SMBI discuss buying, selling, financing and managing small and medium sized businesses...Listen on: Apple Podcasts Spotify

KardioBeat – Der Kardio Podcast
DGK 2024 – Was gab es Neues?

KardioBeat – Der Kardio Podcast

Play Episode Listen Later May 9, 2024 33:31


In der 13. Folge des Kardio-Podcasts ist der diesjährige Tagungspräsident der DGK Jahrestagung Prof. Dr. Christoph Maack zu Gast bei Prof. Dr. David Duncker und spricht mit ihm über die zentralen Themen des Kongresses, der unter dem Motto „Schnittstellen der Kardiovaskulären Medizin“ stattfand.

The Nine Club With Chris Roberts
#318 - Jack Curtin & Brian Reid

The Nine Club With Chris Roberts

Play Episode Listen Later Mar 25, 2024 133:42


Jack Curtin & Brian Reid discuss how Brian got on DGK, Jack leaving DGK for Skate Mental then going back to DGK, Jack & Brian skating for New Balance, Jack's New Balance Pulaski shoe, how Jamie Thomas has Jack's back, maneuvering in the industry as an older skater, Brian going pro for DGK, Jack barfing up burgers that Lutzka bought him and much more! Timestamps 00:00:00 Brian Reid & Jack Curtin 00:01:39 Eggs (the spot) 00:01:56 How does Jack stay young? 00:03:30 How did Jack and Brian meet 00:04:13 How Brian got on DGK 00:05:48 Jack's New Balance Pulaski shoe 00:08:33 Jack leaving DGK for Skate Mental then going back to DGK 00:18:28 Maneuvering in the industry as an older skater 00:20:53 Brian going pro 00:31:45 The return of iconic spots 00:36:32 Getting hooked up by New Balance 00:42:25 The DC tour days 00:46:49 Jack on Fallen Footwear 00:54:07 Jamie Thomas has Jack's back 00:55:41 Zero x DGK fresh til death tour 00:56:20 Jack going to japan with FTC 01:05:29 Tampa contests 01:06:18 Jack barfing up burgers that Lutzka bought him 01:12:31 Kelly "the man skater" Hart 01:19:36 Jack getting on Lucky Skateboards 01:26:31 Brian in the Raw video 01:32:03 Basmati Brian 01:34:54 Brian plays the sax 01:36:42 How did Brian find skateboarding 01:41:25 Kelly immortalized 01:47:10 The NB we got now commercial with Jack Learn more about your ad choices. Visit megaphone.fm/adchoices

The Nine Club With Chris Roberts
Nine Club Live #33 | Yuri Facchini, Shocking Moments Caught On Video

The Nine Club With Chris Roberts

Play Episode Listen Later Jan 24, 2024 194:13


New Balance Numberic 2023 Year in Review, Marcello Campanello, Jante 9:19, Budget or Buttery, Damon byrd 1992 Union part, Jack Curtin on DGK, Josh Kalis killing his Home Park, Lucas Puig Adidas Skateboarding presents Machi Mockil, Yuri Facchini Shake Junt Part, Giorgi Armani's got a new trick, Feather by Felix Soto, Shocking Moments Caught on Video, Joseph Campos for Hockey and much more! Timestamps 00:00:00 Nine Club Live #33 00:01:52 Kelly blew his back out 00:05:00 Topics be dropping 00:06:20 throwaway clips? 00:08:00 Chris's Pretty Sweet Line 00:14:00 Superchat Appreciation give back!!! 00:16:50 Philip The Bucket is back, and ain't no trash can 00:21:00 New Balance Numberic 2023 Year in Review 00:29:00 Marcello Campanello 00:33:00 I'm Glad I'm not me shuv it skate vs Paul Rodriguez 00:36:00 Happy birthday Javier Nunez and Rick McCrank 00:38:00 Jeron went to the Baker has a deathwish part 2 premier 00:41:00 Jante 9:19 00:58:00 Us in a Bus 00:59:45 Budget or Buttery? 01:23:51 Chris's first board graphic Natas re-screened on Jason Lee? 01:28:00 Damon byrd 1992 Union part 01:32:00 Airwalk of past and current at walmart now 01:39:00 Jack Curtin on DGK and Josh Kalis killing his Home Park 01:46:00 Lucas Puig Adidas Skateboarding presents Machi Mockil and Mino Skateboards 01:56:00 Yuri Facchini Shake Junt Part 02:02:00 Giorgi Armani's got a new trick 02:08:00 Feather by Felix Soto 02:26:42 Is there a way to get your trick without escalating a situation with a security guard 02:35:00 Shout out to LMNT 02:39:00 Superchat Appreciation give back #2!!!! 02:43:00 Shocking Moments Caught on Video, Joseph Campos for Hockey 02:54:00 Wrap-up 02:56:00 Last minute SOTY board update!!! Learn more about your ad choices. Visit megaphone.fm/adchoices

First Smoke of The Day
Boo Johnson - Episode 110

First Smoke of The Day

Play Episode Listen Later Oct 2, 2023 116:06


Face of Pro Skateboarding & Weed, Ayahuasca Ceremony, DGK x RAW Collab, Launching Business'sIt's that time! Roll up, today we have Boo Johnson pro skateboarder and the face of cannabis culture X skateboarding combined. We dive deep into Ayahuasca Ceremonies and the lessons they leave with you. Talking about the first time Boo ever smoked cannabis and what it was like on those early skate trips as a teen. Getting deep into the skate scene and getting signed by the Powell-Peralta team. Boo's career insights as it all starts to take off for him and becoming a professional skateboarder. Inspirations like Stevie Williams and how Boo got into the business side of the industry and self branding. Some of the most inspirational lessons Boo leaves us with is how he collaborates and launches multiple products around his lifestyle and interests. Just to name a few Collaborations like Raw Rolling papers, Pharmacy Board shop, Cure Company Cannabis, (JHF) Just Have Fun Co, Long Beach Creamery, BooHooMan Clothing, DGK, Supra, Diamond Supply, Hawkers Co, Spy Sunglasses and many more. Light up, Listen in, and let's take a ride it's FSOTD x Boo J!!Connect with Nicky DiamondsInstagram - Boo JohnsonFSOTD SponsorsDr. Dabber | IGGrow Generation | IGDrip Hydro | IGFSOTD LinksWebsite | YouTubeMake sure to tell all your friends and family to subscribe! Go register on the website for all the exclusive ad-free content, BTS, tutorials, and more! Please leave a 5-Star review! We appreciate your support, First Smoke Family! Hosted on Acast. See acast.com/privacy for more information.

Vechtersbazen
‘Chandler wil hetzelfde als Gaethje en Poirier' | De Gouden Kooi | UFC Vegas 79

Vechtersbazen

Play Episode Listen Later Sep 25, 2023 57:52


In een ouderwetse DGK wordt stilgestaan bij de horrorblessure van Fiziev tijdens UFC Vegas 79. En tegen wie moet Gamrot nu vechten? Had de scheidsrechter The Karate Hottie moeten beschermen? Verder uiteraard aandacht voor de kijkersvragen, Marcel's nieuws en de nieuwe Gokken op Knokken tussenstand.Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.

The Nine Club With Chris Roberts
F*** it, We'll Do It Live! | Nine Club Live - #1

The Nine Club With Chris Roberts

Play Episode Listen Later Jun 2, 2023 147:16


Muni in Philly getting torn down, Brooklyn Banks is open to the public to skate, Jeron at P-Rods Park & his guest Thank You boards, JIT - WKND Skateboards, Robbie Mckinley tribute video, Budget Or Buttery, Nike SB "Gassed Up" video, Antwuan Dixon Instagram clips, Paulo Diaz guest board on DGK, New Distribution called Sidewalk new skate company's Jacuzzi & Opera, Sora Shirai at the Uprising contest in Japan, Versace Plug back on the gram, Franky Villani's "417" New Balance Numeric Part, Oscar Candon - Giddy #13 Abseiling Down part, ACE Presents "Sonhos Lúcidos", Hawk vs Wolf's 100th episode featuring Andrew Reynolds, Chad Caruso skated 3,000 miles across the United States and much more! Learn more about your ad choices. Visit megaphone.fm/adchoices

WCRP on Skateboarding
WCRP: Stevie Williams Pt.2- Illadelphia's Finest

WCRP on Skateboarding

Play Episode Listen Later Mar 23, 2023 39:15


Season 5 has gotten off to an incredible start. Let's keep things rolling, with Part 2 of my exclusive interview with Illadelphia's Finest, skateboarding LEGEND- Stevie Williams. Tune in, as Stevie talks the cultural impact of DGK skateboards. Speaks on his former RBK deal, Asphalt Yacht Club & the rise of corporate deals in skateboarding. Opens up about family, success & his climb to the top. We take another deep-dive into history, and discuss Mike McGil & Shaft Skateboards. Skateboarding LEGEND- Kareem Campbell, Saved By Skateboarding, Pharrell Williams.. hell, we even got Frankie Hill up in the mix. Strictly, culture. Strictly, talk-radio. It's the mighty, mighty WCRP on Skateboarding.

The Nine Club With Chris Roberts
Manramp, Kai Kishi, Jaws, Neen, Decenzo, Handy Handerson | EXPERIENCE #227

The Nine Club With Chris Roberts

Play Episode Listen Later Dec 22, 2022 127:07


Manramp's "Worble World" Part, Jaws, Neen, Decenzo, and Fp Footwear in Barcelona, Andrew Skate Shop's "RASCAL" video, What will happen to the West LA Courthouse Skate Spot, Budget Or Buttery, Handy Handerson, Eldy's Pick Of The Week, SUCKER PUNCH | Roger Skate Co video, April skateboards "KAI KISHI" part, Jeron swearing Live on Fox at a Street League, Will Mazzari pro for DGK and much more! Learn more about your ad choices. Visit megaphone.fm/adchoices

Dirty Glove Bastard: Off The Porch
Tedros Kassa DGB Off The Porch Interview

Dirty Glove Bastard: Off The Porch

Play Episode Listen Later Nov 28, 2022 50:27


Interview by Manny Akiio https://www.instagram.com/mannyakiio Recently we connected with Tedros Kassa for an exclusive “Off The Porch” interview! During our sit down he talked about being born in Ethiopia, moving to Atlanta when he was 4, jumping off the porch, lessons he learned in the streets, getting sponsored by a skateboard company, moving to New York, linking with DGK, explains how he got into modeling, going back to the streets, explains what lead him to going on the run, getting into making music, getting booked in Canada, shooting somebody in after he was attacked, explains how he was able not to caught while on the run, making half a million in 2 years while on the run, having a trucking company, having to turn himself in a couple days for a 7 year sentence, his musical influences, getting label meetings, touring after one year of rapping, his plans for music when he comes homes, explains what is going on back home in Ethiopia, plans to give back, and much more!

Mostly Skateboarding
DGK's Zeitgeist and Shop Location. November 6, 2022. Mostly Skateboarding Podcast.

Mostly Skateboarding

Play Episode Listen Later Nov 6, 2022 50:05


This week, Jason From Frozen in Carbonite and Mike Munzenrider are talking about DGK's new video: Zeitgeist and skateshop locations.

The Nine Club With Chris Roberts
#236 - Henry Sanchez

The Nine Club With Chris Roberts

Play Episode Listen Later Jul 18, 2022 142:15


Henry Sanchez discusses growing up in Daly City CA, getting on REAL skateboards at 15 years old, skating with Mark Gonzales & Guy Mariano then getting on Blind Skateboards, filming for Tim and Henry's pack of lies, why he didn't skate for Girl Skateboards, coming out of dark times and filming a part for Transworld's Sight Unseen video, skating for Lucky Skateboards after Sight Unseen, working with Stevie Williams for his DGK guest board, why he quit skating for 16 years, what inspires him to skate now and much more! Learn more about your ad choices. Visit megaphone.fm/adchoices

Renewing the Blade
Discipleship - Ch Growth/Renewal/Planting-Bob Logan 1a 3 Ch Planting Types of Leaders Planters

Renewing the Blade

Play Episode Listen Later Jun 24, 2022 2:52


Discipleship - Ch Growth/Renewal/Planting-Bob Logan 1a 3 Ch Planting Types of Leaders Planters by DGK

South Florida Gamers Podcast
SmashCAST Episode 2

South Florida Gamers Podcast

Play Episode Listen Later Mar 22, 2022 116:26


This was one of our best episodes to date. Think of it as the 8 Man podcast version 2.0 except it's with 6 Smash players. We brought back DGK, Joycon and DiscoDude for this episode and along with them are 3 new guests, Undergod, Diavolo and Balboa. Lot of craziness happened on this episode and it is well worth the listen. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/southfloridagamerspodcast/support

The Nine Club With Chris Roberts
Boo Johnson - Stop And Chat

The Nine Club With Chris Roberts

Play Episode Listen Later Nov 19, 2021 127:08


Boo Johnson Stops by and Chats with us about his YouTube channel, getting signed by IMG, acting in a new movie with Machine Gun Kelly, skating for Straye Footwear, skating the Cherry Park gap, the new generation on DGK, how he does hardflip back smith grinds, trying a Paqui Chip, his Pharmacy skate shop in Long Beach, reviewing some of his skate clips and much more!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

South Florida Gamers Podcast

On this episode, Myself and Walooiji have begun a new series called SmashCast, where we bring in any Smash Bros Ultimate player or TO and discuss everything and anything Smash Bros related. We had returning to the podcast, Joycon and DGK and two new guests, Aerodusk and ChocoTaco --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/southfloridagamerspodcast/support

FRANKENBROTHER Skate Video Podcast
Episode 20 (Part 2) - Olympic Skateboarding

FRANKENBROTHER Skate Video Podcast

Play Episode Listen Later Sep 27, 2021 36:17


In Part 2 we discussed the first day of Olympic Skateboarding from the Tokyo Olympics, how 13yo girls shredding that hard makes our creaky bones hurt, and that Tom and Stuart are too old to work out how to use TV apps.  See Part 1 for our discussion about DGK's 2014 video Blood Money. 

FRANKENBROTHER Skate Video Podcast
Episode 20 (Part 1) - BLOOD MONEY (DGK 2014)

FRANKENBROTHER Skate Video Podcast

Play Episode Listen Later Sep 27, 2021 83:53


We split this latest episode into two parts because we simply couldn't shut up and it went on a bit. This first part covers DGK's short Blood Money video but we end up talking about music mostly (again). Part 2 covers the first day of the Olympic Skateboarding street events. 

Mostly Skateboarding
Constant and Kevin Bileu. June 6, 2021. Mostly Skateboarding Podcast

Mostly Skateboarding

Play Episode Listen Later Jun 6, 2021 53:34


This week, Jason From Frozen in Carbonite, Patrick Kigongo, and Mike Munzenrider are talking about Nike SB's new video, Constant and Kevin Bileu's new part for DGK. Listen here and subscribe on iTunes or Spotify.

Accelerated Radio Network
Power of Lipstixx 3/2/2021 (Ep. 49) "Get Comfortable w/ Being Uncomfortable" *Coach Cooley, Mr. Beat Da Odds, & Kween Elavation*

Accelerated Radio Network

Play Episode Listen Later Mar 3, 2021 59:21


Power of Lipstixx with host Kween Elavation airs every Tuesday evening at 6pm PST on AcceleratedRadio.Net

Renewing the Blade
God With Us – Jesus Christ Matt 1:18-25 John Tillery Dec 27, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Dec 30, 2020 35:48


God With Us – Jesus Christ Matt 1:18-25 John Tillery Dec 27, 2020 FCBC by DGK

Renewing the Blade
God With Us – Joy Phil 3:1-13 John Tillery Dec 20, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Dec 30, 2020 37:49


God With Us – Joy Phil 3:1-13 John Tillery Dec 20, 2020 FCBC by DGK

Renewing the Blade
God With Us - Peace Luke 2:8-14 John Tillery Dec 24, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Dec 30, 2020 20:26


God With Us - Peace Luke 2:8-14 John Tillery Dec 24, 2020 FCBC by DGK

Do góry kotami
DGK 010: Bezpieczne Święta i Nowy Rok z kotem

Do góry kotami

Play Episode Listen Later Dec 10, 2020 20:09


Dziś zapraszam na odcinek solowy, w którym opowiem o tym, jak bezpiecznie spędzić z kotem Święta Bożego Narodzenia oraz Sylwestra. Dowiesz się między innymi:

Renewing the Blade
God With Us - Hope Rom 15:7-13 John Tillery Dec 6, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Dec 9, 2020 37:35


God With Us - Hope Rom 15:7-13 John Tillery Dec 6, 2020 FCBC by DGK

Do góry kotami
DGK 009: O pracy lekarza weterynarii - lek. wet. Magdalena Firlej-Oliwa (Weterynarz też człowiek)

Do góry kotami

Play Episode Listen Later Dec 2, 2020 66:42


Dziś nie do końca o kotach, a o zawodzie lekarza weterynarii.W tym odcinku rozmawiamy między innymi:

Renewing the Blade
God With Us - Jesus Coming Soon Rev 22:6-21 John Tillery Nov 29, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Dec 1, 2020 36:34


God With Us - Jesus Coming Soon Rev 22:6-21 John Tillery Nov 29, 2020 FCBC by DGK

The Nine Club With Chris Roberts
Stevie Williams - Stop And Chat

The Nine Club With Chris Roberts

Play Episode Listen Later Nov 30, 2020 119:36


We Stop And Chat with Stevie Williams to discuss what sparked him to work out and skate everyday, what he thinks the skate industry is missing and needs, skating with his son, breaking down some of his most memorable clips, putting Chaz Ortiz on DGK, his relationship with Vergil Abloh, why he’s only filming Instagram clips these days and much more!

Do góry kotami
DGK 008: Jak pomagać kotom bezdomnym - Marta Walicka (Na ratunek bezdomniakom)

Do góry kotami

Play Episode Listen Later Nov 26, 2020 48:12


Moim gościem jest Marta Walicka z Fundacji Na ratunek bezdomniakom.Z tego odcinka dowiesz się między innymi:

Renewing the Blade
The Eternal State p.2, Rev. 22:1-5 John Tillery Nov 22, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Nov 23, 2020 38:46


The Eternal State p.2, Rev. 22:1-5 John Tillery Nov 22, 2020 FCBC by DGK

Do góry kotami
DGK 007: Kot w duchu less waste - Julia Wizowska (Na nowo śmieci)

Do góry kotami

Play Episode Listen Later Nov 18, 2020 51:03


Gościem 7. odcinka jest Julia Wizowska - autorka bloga "Na nowo śmieci" oraz książki "Nie śmieci". Rozmawiamy o tym, czym właściwie jest less waste i jak można stosować to podejście w odniesieniu do kotów. Z tego odcinka dowiesz się między innymi:

Renewing the Blade
The Eternal State, Rev. 21:1-27 John Tillery Nov 15, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Nov 16, 2020 40:48


The Eternal State, Rev. 21:1-27 John Tillery Nov 15, 2020 FCBC by DGK

The Adam Dunn Show
TADS111320 - The Adam Dunn Show 11 - 13 - 20

The Adam Dunn Show

Play Episode Listen Later Nov 14, 2020 166:02


What a crazy show we have this week Former Governor of New Mexico and 2 time presidential candidate GARY JOHNSON will join us this week to discuss the Future of Cannabis under a new administration, we will also get our monthly legal advice from JEFF GARD “THE GUARDDOG” but not to get too deep in the political and legal landscape we will be virtually chilling with our friend BLEU DAVINCI this time he will be bringing professional skater , entrepreneur and all around bad ass STEVIE WILLIAMS of DGK to the mix. Of course “JAMEZ BEAN MAN ON THE SCENE” will bring us latest news..news...news hope to see ya there! #adamdunnshow #seedsherenow #newmilleniumnutrients #buildasoil #greenfarmsmed #iloveincredibles #tresorbcn #fishshit #42oextractor #extractcraft #dunndeal #14er #jamesbeanmanonthescene #numbnuts #ozocoffee #DJC #apothacaryextractsco #DGK #bleudavinci #garyjohnson #steviewilliamsdgk #jeffgard

Renewing the Blade
The Millennial Reign of Christ, Rev. 20:1-15 John Tillery Nov 8, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Nov 13, 2020 36:28


The Millennial Reign of Christ, Rev. 20:1-15 John Tillery Nov 8, 2020 FCBC by DGK

Do góry kotami
DGK 006: Czy hodowle kotów są potrzebne? - Dorota Szadurska (Zrozumieć kota)

Do góry kotami

Play Episode Listen Later Nov 4, 2020 55:58


Gościem 6. odcinka jest Dorota Szadurska - kocia behawiorystka, hodowca i sędzina felinologiczna. Rozmawiamy o kotach bezdomnych i tych z hodowli.

Do góry kotami
DGK 005: Kot rasowy - Jak mądrze wybrać hodowlę?

Do góry kotami

Play Episode Listen Later Oct 21, 2020 36:50


Jak sprawdzić, czy hodowla jest legalna? Jakie sztuczki stosują pseudohodowle? Czy odwiedziny w hodowli są konieczne? Na te, jak i znacznie więcej pytań dotyczących wyboru hodowli postaram się odpowiedzieć w piątym odcinku podcastu. Serdecznie zapraszam do wysłuchania.

Renewing the Blade
The Marriage Supper of the Lamb, Rev. 19:6-10 John Tillery Sept 27, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Oct 2, 2020 35:43


The Marriage Supper of the Lamb, Rev. 19:6-10 John Tillery Sept 27, 2020 FCBC by DGK

Renewing the Blade
Commerce In The Great Tribulation, Rev. 17 - 18 John Tillery Sept 20, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Sep 29, 2020 39:34


Commerce In The Great Tribulation, Rev. 17 - 18 John Tillery Sept 20, 2020 FCBC by DGK

PaperPlayer biorxiv neuroscience
Pioglitazone improves deficits of Fmr1-KO mouse model of Fragile X syndrome by interfering with excessive diacylglycerol signaling

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Sep 22, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.22.301762v1?rss=1 Authors: Geoffroy, A., Habbas, K., Zambo, B., Schramm, L., Duchon, A., Flatter, E., Fouillen, L., Zumsteg, J., Heintz, D., Mandel, J.-L., Herault, Y., Moine, H. Abstract: Fragile X syndrome (FXS), the leading cause of familial intellectual disability, is an uncured disease caused by the absence or loss of function of the FMRP protein. FMRP is an RNA binding protein that controls the translation of specific proteins in neurons. A main target of FMRP in neurons is diacylglycerol kinase kappa (DGKk) and the loss of FMRP leads to a loss of DGK activity causing a diacylglycerol excess in the brain. Excessive diacylglycerol signaling could be a significant contributor to the pathomechanism of FXS. Here we tested the contribution of DAG-signaling in Fmr1-KO mouse model of FXS and we show that pioglitazone, a widely prescribed drug for type 2 diabetes, has ability to correct excessive DAG signaling in the brain and rescue behavioral alterations of the Fmr1-KO mouse. This study highlights the role of lipid signaling homeostasis in FXS and provides arguments to support the testing of pioglitazone for treatment of FXS. Copy rights belong to original authors. Visit the link for more info

Renewing the Blade
Religion in the Great Tribulation, Rev. 17:1-18 John Tillery Sept 13, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Sep 18, 2020 36:54


Religion in the Great Tribulation, Rev. 17:1-18 John Tillery Sept 13, 2020 FCBC by DGK

Renewing the Blade
The Bowls Part 2, Rev. 16:8-21 John Tillery Sept 6, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Sep 9, 2020 36:24


The Bowls Part 2, Rev. 16:8-21 John Tillery Sept 6, 2020 FCBC by DGK

Renewing the Blade
The Lamb and the 144,000 on Mt Zion Rev 14:1-5 John Tillery August 2, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Sep 4, 2020 39:26


The Lamb and the 144,000 on Mt Zion Rev 14:1-5 John Tillery August 2, 2020 FCBC by DGK

Renewing the Blade
Reaping the earth's harvest Rev 14:14-20 John Tillery August 16, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Sep 4, 2020 40:06


Reaping the earth's harvest Rev 14:14-20 John Tillery August 16, 2020 FCBC by DGK

Renewing the Blade
The Bowls Part I, Rev. 16:1-7 John Tillery August 30, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Sep 4, 2020 36:25


The Bowls Part I, Rev. 16:1-7 John Tillery August 30, 2020 FCBC by DGK

Renewing the Blade
The Coming Of Christ Part 2

Renewing the Blade

Play Episode Listen Later Jul 22, 2020 28:45


The Coming Of Christ Part 2 by DGK

Renewing the Blade
Depression (era) Inspiration Edgar Guest - It Can't Be Done & The Old Golfer Dies

Renewing the Blade

Play Episode Listen Later Jul 19, 2020 6:47


Depression (era) Inspiration Edgar Guest - It Can't Be Done & The Old Golfer Dies by DGK

Renewing the Blade
Depression (era) Inspiration Edgar Guest Creed & Supper's Ready

Renewing the Blade

Play Episode Listen Later Jul 19, 2020 6:00


Depression (era) Inspiration Edgar Guest Creed & Supper's Ready by DGK

Renewing the Blade
Depression (era) Inspiration Edgar Guest About Golf Scores & Failures

Renewing the Blade

Play Episode Listen Later Jul 19, 2020 6:01


Depression (era) Inspiration Edgar Guest About Golf Scores & Failures by DGK

Renewing the Blade
Depression (era) Inspiration Edgar Guest See It Through & Sticky Kiss

Renewing the Blade

Play Episode Listen Later Jul 19, 2020 4:31


Depression (era) Inspiration Edgar Guest See It Through & Sticky Kiss by DGK

Renewing the Blade
Depression (era) Inspiration Edgar Guest Strength & Growing Down

Renewing the Blade

Play Episode Listen Later Jul 19, 2020 5:33


Depression (era) Inspiration Edgar Guest Strength & Growing Down by DGK

Renewing the Blade
Depression (era) Inspiration Edgar Guest The Golden Chance & The Man To Be

Renewing the Blade

Play Episode Listen Later Jul 19, 2020 7:20


Depression (era) Inspiration Edgar Guest The Golden Chance & The Man To Be by DGK

Renewing the Blade
Depression (era) Inspiration Edgar Guest The Sulker & True Nobility

Renewing the Blade

Play Episode Listen Later Jul 19, 2020 5:16


Depression (era) Inspiration Edgar Guest The Sulker & True Nobility by DGK

Best of Wondery
The Dating Game Killer — Tali

Best of Wondery

Play Episode Listen Later Jun 15, 2020 52:33


Eight-year-old Tali Shapiro is abducted on her way to school. At the crime scene, LAPD officer Chris Camacho finds her attacker’s student ID. His name: Rodney Alcala.Listen to the full series: wondery.fm/bestofwondery_DGK.

Renewing the Blade
An Interval, an Angel, and Two Witnesses Rev. 10:1-11:14 John Tillery May 31, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Jun 1, 2020 41:24


An Interval, an Angel, and Two Witnesses Rev. 10:1-11:14 John Tillery May 31, 2020 FCBC by DGK

Renewing the Blade
The 6th Seal Rev. 9:13 - 21 Dan Kachikis May 24, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Jun 1, 2020 56:51


The 6th Seal Rev. 9:13 - 21 Dan Kachikis May 24, 2020 FCBC by DGK

Renewing the Blade
The 5th Trumpet Rev. 9:1-12 John Tillery May 17, 2020 FCBC

Renewing the Blade

Play Episode Listen Later May 22, 2020 36:29


The 5th Trumpet Rev. 9:1-12 John Tillery May 17, 2020 FCBC by DGK

No Mongo Podcast
Better Late Than Never: DGK 'Parental Advisory'

No Mongo Podcast

Play Episode Listen Later May 9, 2020 12:26


For this installment of Better Late Than Never I discuss the first full-length video from DGK titled 'Parental Advisory' from 2012. Clocking in at just over an hour it was time well spent, but definitely worthy of the title/warning. Let me know your favorite tricks and/or riders from this one. Email the show nomongopodcast@gmail.com www.nomongo.com    

Renewing the Blade
The Sealing Of The 144,000 Rev. 7 John Tillery April 26, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Apr 26, 2020 41:33


The Sealing Of The 144,000 Rev. 7 John Tillery April 26, 2020 FCBC by DGK

Renewing the Blade
The Opening of the Seals Rev. 6 Dan Kachikis April 19, 2020

Renewing the Blade

Play Episode Listen Later Apr 19, 2020 56:03


The Opening of the Seals Rev. 6 Dan Kachikis April 19, 2020 by DGK

Renewing the Blade
The Letter to the Church of Philadelphia Revelation 3:7-13 John Tillery March 15, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Mar 24, 2020 34:27


The Letter to the Church of Philadelphia Revelation 3:7-13 John Tillery March 15, 2020 FCBC by DGK

Renewing the Blade
The Letter to the Church at Sardis Revelation 3:1-6 John Tillery Mar 1, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Mar 3, 2020 39:33


The Letter to the Church at Sardis Revelation 3:1-6 John Tillery Mar 1, 2020 FCBC by DGK

Renewing the Blade
The Church at Thyatira Revelation 2:18-29 John Tillery Feb. 23, 2020 FCBC

Renewing the Blade

Play Episode Listen Later Feb 28, 2020 38:48


The Church at Thyatira Revelation 2:18-29 John Tillery Feb. 23, 2020 FCBC by DGK

Caffeine & Green
#48 - Darius "Woogie" Jackson

Caffeine & Green

Play Episode Listen Later Jul 20, 2019 55:09


Darius Jackson is a Amateur skateboarder that skates for DGK, 9five, DC shoes, Thunder trucks, Diamond Supply Co., Nothing special bearings, Remind Insoles, and Arts & Rec. He is local legend and the future of skateboarding. Keep your eyes peeled for this legend in the making. Instagram: @blackasswoogie   How to Reach Caffeine & Green  Instagram: @caffeine_and_green Email: caffeinengreen@gmail.com   Coffee!!!! Get 3 bags of Coffee for $30  USE CODE: "CANDG" Charity coffee's excluded from offer sevenseasroasting.com/pages/coffee 

Work In Progress
#73 How Don Cooley Is Changing The World One DGK Skateboard at a Time

Work In Progress

Play Episode Listen Later Mar 4, 2019 39:24


Don Cooley runs the Saved By Skateboarding Initiative at a well-known skateboarding company called DGK. Saved By Skateboarding is the brand's philanthropic organization where they go into low income neighborhoods and gift free skateboarding equipment to the kids so that they have a healthy outlet.

University of Adversity
Ep. 21 Designing Your Best Life with Barton Damer

University of Adversity

Play Episode Listen Later Feb 10, 2019 38:14


Barton is a motion designer and digital artist who creates under his studio brand, Already Been Chewed. He has designed for a variety of mediums including print, web, live productions and broadcast television. Barton has worked on campaigns for Nike, Supra Footwear, DGK, and Street League Skateboarding, as well as, Lil Wayne, Rob Dyrdek, Toby Mac, and Stevie Williams are some of the pop icons that Barton has created media for over the years.In this episode, Barton talks about how his skateboarding injuries allowed him to explore art from drawing, to filming and editing videos. As he was once on a traditional college path, Barton changed his major to visual arts when he realized that his interest in design grew as a passion and he recognized his natural talent and quickly excelled. Barton explains that as an artist and designer, it’s very easy to get caught up in the same routine and begin losing the creativity that drives original ideas. He stresses the importance of having to go through adversity in order to get to the success you want.Connect with Barton:Learn more about Already Been Chewed on InstagramConnect with Barton on InstagramConnect with Lance:Subscribe on Messenger to get the latest episodes and tips straight to your inbox! Connect with Lance on Facebook, Instagram, or LinkedIn. About University of Adversity PodcastLearn how to overcome failure and tragedy, while becoming your best self with the University of Adversity podcast. Join your host Lance Essihos as he interviews successful individuals that have fought the hard battles to overcome life’s obstacles. Lance started the University of Adversity podcast after overcoming his own adversities shared in episode 01. Join him and thousands of other entrepreneurs in learning how to use Adversity as a fuel to ignite your inner flame and live the life you have always desired. Tune in weekly for a dose of positivity, strength, and real-life practical advice to achieve your life goals.Support the show (https://www.lanceessihos.com/)

Car Thoughts with David
#SavedbySkateboarding with Don Cooley

Car Thoughts with David

Play Episode Listen Later Feb 5, 2019 33:56


Today on the show in got a chance to interview Don Cooley of DGK Skateboards and he oversees the companies #SavedBySkateboarding initiative where they go in and give out skateboards to kids and give them an alternative to those negative influences. We touched on so many great subjects and life lessons and how when you are doing things for the right reasons the rest will follow! You can find Don on Instagram @itscooley and @doncooleytv Interested in learning more about DGK go to www.dgkallday.com proceeds from every purchase go to #savedbyskateboarding initiative. You can also google #savedbyskateboarding and find so many great posts about the work the Don, his team and the DGK family does in the skateboarding community and in cities across the US... and with skateboarding going into the olympics in 2020 soon to be the world. Website: https://carthoughtswithdavid.com --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/davidc/message Support this podcast: https://anchor.fm/davidc/support

The Nine Club With Chris Roberts
#60 - Boo Johnson

The Nine Club With Chris Roberts

Play Episode Listen Later Aug 14, 2017 79:42


Boo Johnson discusses growing up in Tehachapi CA, getting hooked up with Pharmacy Boardshop, his first board sponsor Powell, filming for his first video part on Element ’Future Nature’, getting on DGK, starting his own company JHF, his years with Supra, skating for Weedmaps, Torrey hitting him up to ride for Diamond Footwear, designing his pro shoe the Boo J, riding for Hawkers and much more...

The Nine Club With Chris Roberts
#44 - Stevie Williams

The Nine Club With Chris Roberts

Play Episode Listen Later Apr 17, 2017 92:27


  Stevie Williams discusses growing up skating Love Park in Philly, getting sponsored at 12, how riding for Chocolate changed his life, meeting Michael Jackson, what his involvement is now with DGK, the illuminataums, Asphalt Yacht Club, his new business endeavor, Ruth's Chris Steakhouse and much more...

Rhyme Different
Rhyme Different with Al Freshko (Designer)

Rhyme Different

Play Episode Listen Later Apr 17, 2017 106:22


In this Episode we talk to Al Freshko Designer for Brands like Cookies, Diamond clohing, DGK, Freshko Clothing. Al Fresko talks about how he grew up in the bay area & everything he had to go through.

Rhyme Different
#2 Rhyme Different

Rhyme Different

Play Episode Listen Later Feb 24, 2017 106:22


On this Episode we talk to Alfreshko Designer of brands like Cookies, DGK,Freshko Clothing and Many more Listen to his story of how he grew up in the Bay Area, How he had to really struggle to make it out. We all got a Story.

The Nine Club With Chris Roberts
#35 - Wade DesArmo

The Nine Club With Chris Roberts

Play Episode Listen Later Feb 13, 2017 65:56


  Wade DesArmo discusses growing up in Ottawa Canada, winning the world Karate championship at age 11, the struggle of coming up in Canada, finally getting on DGK, the rise and fall of the ghetto gown, people thinking he doesn't skate because he's not active on social media and much more...

The Nine Club With Chris Roberts
#29 - Jack Curtin

The Nine Club With Chris Roberts

Play Episode Listen Later Dec 26, 2016 48:02


Jack Curtin discusses growing up overseas, discovering skating in Indonesia, living in SF, getting sponsored, quitting DGK for Skate Mental, past shoe sponsors, skating for New Balance and much more!   

The Bunt
The Bunt S02 Episode 10 Ft. Stevie Williams "Flew first class, f***ed up hella shrimp"

The Bunt

Play Episode Listen Later Oct 26, 2016 58:37


1. Stevie Williams interview 2. Coming up in Philly/Love Scene (5:20) 3. Stevie and Kalis brotherhood (9:13) 4. Riding for Chocolate Skateboards (10:05) 5. Starting DGK and discovering Wade D(11:53) 6. RBK/DGK (16:22) 7. Hardflips (20:13) 8. Stevie and D Harper(22:42) 9. Taking a step back from DGK (24:04) 10. In the Streets with Wade D ft. Ariel Pearl(26:56) 11. AYC (30:00) 12. Rick Ross vs DGK (35:28) 13. Switch pop shuv revert (37:15) 14. Love Park next generation (42:00) 15. What's next for Stevie (48:11) 16. Rapid Fire with Da Ghost (51:31) 17. The Rundown - NFL week 7 recap, NBA tip off (54:39)

The Bunt
The Bunt S02 Episode 4 Ft. Darren Harper "I consider myself the 50 Cent of skateboarding"

The Bunt

Play Episode Listen Later Sep 14, 2016 65:10


1. Darren Harper Interview 2. Coming up in Washington (3:55) 3. Park Police after Darren (7:42) 4. Big pop makes a splash in skating (10:17) 5. Getting on DGK skateboards (15:14) 6. In the Streets with Wade D Ft. Forrest Edwards (17:10) 7. Fallout with Stevie Williams and DGK (19:44) 8. Confronting Stevie Williams (23:06) 9. The hunt for Spencer Fujimoto (27:00) 10. Stevie and Darren are still brothers (34:53) 11. What's next for Darren (36:05) 12. Rapid Fire with Da Ghost (38:32) 13. Post Office (43:26) 14. The Rundown - Basketball HoF class of 2016, NFL week 1 takeaways, Top 5 fantasy QB's (52:00)

Podcasts – Werner Eberwein
Warum gehört die Körperpsychotherapie zur Humanistischen Psychotherapie?

Podcasts – Werner Eberwein

Play Episode Listen Later Sep 13, 2015


In einem 9-minütigen Kurzvortrag habe ich (Werner Eberwein) auf dem Kongress der Deutschen Gesellschaft für Körperpsychotherapie (DGK) 10.-13.9.2015 ausgeführt, warum die Körperpsychotherapie trotz ihrer historischen und konzeptuellen Bezüge zu psychodynamischen Richtungen ein humanistischer Ansatz ist: Körperpsychotherapie und Humanistische Psychotherapie Das Problem, aus dem heraus wir 2010 die Arbeitsgemeinschaft Humanistische Psychotherapie gegründet haben, war die Frage: […]

Thrasher Radio
Thrasher Radio: Ep. 25 Jack Curtin

Thrasher Radio

Play Episode Listen Later Jun 9, 2014 16:26


From butt boarding to DGK. Jack clues us into his story of stoke. Thrasher Radio Ep.25 Track List: Young Thug - “Stoner” RBL Posse - “Bammer Weed” Kendrick Lamar - “Money Trees” The Black Keys - “10 Lovers” Dee Edwards - “Why Can't There Be Love?” The Rolling Stones - "Gimmie Shelter" Schoolboy Q - "Man Of The Year" Who do you want to see on the show? Let us know by email: ThrasheRADio@Thrashermagazine.com

Springer Medizin Podcast
Frauen zwischen Hoffen und Bangen

Springer Medizin Podcast

Play Episode Listen Later Mar 5, 2008 16:06


Werdende Mütter haben hohe Erwartungen an die Geburtshilfe. Neben körperlicher Unversehrtheit wünschen sich die meisten Schwangeren viel Mitspracherecht, gute Zusammenarbeit mit Ärzten und Hebammen sowie die Anwesenheit des Lebenspartners bei der Geburt. Außerdem: Der DGK-Kongresspräsident Prof. Piper über Notfalltherapien beim Herzinfarkt, Prof. Ertl, Präsident der DGIM, über die Highlights des Internistenkongresses und Dr. Dirks über die Gründung des GRC.

Springer Medizin Podcast
Therapie bei Mama

Springer Medizin Podcast

Play Episode Listen Later Oct 12, 2007 16:52


Pubertät ist schwierig. Besonders, wenn die Heranwachsenden an einer Krankheit wie Diabetes leiden. Dann werden Eltern zu Therapeuten. Eine Schulung der Beteiligten ist unabdingbar, fordern Experten. Außerdem: Neuigkeiten von der DGK-Herbsttagung, erläutert von Professor U. Tebbe und Professor W. Schöls. Der Kongresspräsident Professor M. Fey berichtet über Aktuelles des DGHO-Kongresses in Basel.

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 02/06
Identifizierung und Charakterisierung neuer Interaktoren des von Hippel-Lindau Tumorsuppressors

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 02/06

Play Episode Listen Later Oct 10, 2005


Die Inaktivierung des von Hippel-Lindau (VHL) Tumorsuppressors spielt eine Rolle in der Entstehung von verschiedenen gut- und bösartigen Tumoren mit hoher Gewebespezifität. Als substraterkennende Untereinheit des CBCVHL Ubiquitin Ligase Komplexes steuert VHL den sauerstoffabhängigen Abbau des Transkriptionsfaktors HIF1/2α. HIF1/2α aktiviert die Transkription einer Vielzahl von Faktoren, die für den Energiehaushalt der Zelle und die Blutgefäßneubildung von entscheidender Bedeutung sind. Die Akkumulation von HIF1/2α führt zu deren konstitutiver Expression und fördert somit das Wachstum von Tumoren durch eine verbesserte Nährstoffversorgung. Der sauerstoffabhängige Mechanismus der HIF-Erkennung wird durch die Aktivität einer neuen Familie von Prolylhydroxylasen reguliert, die möglicherweise ihrerseits eine Reihe von zellulären Substraten haben. Trotz der guten Korrelation zwischen bestimmten, den HIF-Abbau beeinflussenden VHL-Mutationen und dem Auftreten von verschiedenen Krankheitssubtypen sind noch nicht alle Phänotypen im Zusammenhang mit VHL erklärbar. Vor allem die Identifizierung neuer Substrate für den CBCVHL Komplex ist für ein umfassendes Verständnis der VHL-Krankheit von Interesse. In dieser Arbeit wurden unterschiedliche Methoden zur Identifizierung neuer Substrate von VHL angewendet. Durch Affinitätschromatographie mit einem rekombinanten Komplex aus VHL, Elongin B und Elongin C (VCB) konnte Daxx als neuer Interaktor von VHL identifiziert werden. Daxx bindet Elongin B/C-unabhängig an VHL, und seine Stabilität wird nicht durch VHL reguliert. Zudem bildet Daxx einen Komplex mit dem VHL-Substrat HIF1α. Dies weist auf eine mögliche Funktion von VHL neben seiner Rolle als Ubiquitin Ligase hin, z.B. in der Regulation von Daxx als transkriptionellem Repressor. In einem funktionalisierten „TwoHybrid“-Screen konnte der Mechanismus der HIF-Regulation in S. cerevisiae rekonstituiert werden. Dies ermöglichte die Identifizierung weiterer potentieller VHL-Substrate, unter anderem Diacylglycerol Kinase iota (DGKι). DGKι weist zwei Erkennungsmotive für Prolylhydroxylasen auf und wird in Gehirn und Retina exprimiert. In diesem Organen kommt es bei VHL-Patienten zur Entstehung von Hämangioblastomen. DGKι wird in vivo ubiquityliert und bindet sowohl an VHL, als auch an zwei der drei bekannten Prolylhydroxylasen. Mit Mutanten von DGKι konnte allerdings gezeigt werden, dass Bindung und Ubiquitylierung nicht über den gleichen Mechanismus erfolgen wie bei HIF1α. Möglicherweise spielen Ubiquitylierung und VHL-Bindung getrennte Rollen in unterschiedlichen zellulären Prozessen. Es wird zunehmend deutlicher, dass VHL nicht nur eine Komponente des CBCVHL Komplexes bildet, sondern weitere Funktionen in der Zelle erfüllt. VHL spielt eine Rolle in der Assemblierung der Fibronektinmatrix, der Regulation von Mikrotubulistabilität und –dynamik und der Transkriptionskontrolle. Eine weitere Charakterisierung des nicht-degradativen Einflusses von VHL auf die in dieser Arbeit beschriebenen Bindungspartner ist nötig, um die zelluläre Wirkungsweise von VHL vollständig zu verstehen.