Podcasts about GTP

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

In this “Evening With a Legend” episode, we interview Mark Raffauf, IMSA's Senior Director of Competition, tracing how IMSA's early relationship with the ACO grew from the 1970s through the creation of GTP, the split from FIA Group C's fuel-formula approach, and the IMSA-driven development that helped shape cars like the Porsche 962. Mark recounts 1980s GTP's manufacturer battles and behind-the-scenes antics, then explains the 1990s shift to World Sports Car, Ferrari's 333 SP, and how rule changes at Le Mans affected competitiveness. He details IMSA's organizational split that led to ALMS and Grand-Am, the rise of Daytona Prototypes, and today's cost-control challenges. The conversation culminates in a deep discussion of Balance of Performance, LMDh vs hypercar sustainability, lift-and-coast strategy, and the need for a common future platform beyond 2030, while emphasizing Le Mans as a global mega-event. ===== (Oo---x---oO) ===== 00:00 Meet Mark Raffauf 02:20 Early IMSA and ACO Ties 04:25 Birth of GTP Rules; Group C vs GTP Debate 09:02 Porsche 956 to 962 Shift 11:26 Golden Era Grid Battles 17:45 Nineties Reset and WSC 20:39 Ferrari 333 SP Moment 23:44 Rule Drift and Audi's Rise 26:19 ALMS & Grand Am Split 30:23 Cost Control Lessons 32:43 How BOP Really Works 33:28 LMDh versus Hypercar Basics 37:56 Why One Rulebook Matters 43:32 "Lift and Coast" Energy Management Explained 46:33 Getting more Hypercars to IMSA 50:35 Endurance Racing As Events 54:58 Future Platform, 2030 and beyond 59:27 Final Thanks And Wrap Up ==================== The Motoring Podcast Network : Years of racing, wrenching and Motorsports experience brings together a top notch collection of knowledge, stories and information. #everyonehasastory #gtmbreakfix - motoringpodcast.net More Information: Visit Our Website Become a VIP at: Patreon Online Magazine: Gran Touring Follow us on Social: Instagram To learn more about or to become a member of the ACO USA, look no further than www.lemans.org, Click on English in the upper right corner and then click on the ACO members tab for Club Offers. Once you become a Member you can follow all the action on the Facebook group ACOUSAMembersClub; and become part of the Legend with future Evening With A Legend meet ups.

Two Onc Docs, hosted by Samantha A. Armstrong, MD, and Karine Tawagi, MD, is a podcast dedicated to providing current and future oncologists and hematologists with the knowledge they need to ace their boards and deliver quality patient care. Dr Armstrong is a hematologist/oncologist and assistant professor of clinical medicine at Indiana University Health in Indianapolis. Dr Tawagi is a hematologist/oncologist and assistant professor of clinical medicine at the University of Illinois in Chicago.In this episode, OncLive On Air® partnered with Two Onc Docs to provide a comprehensive review of data from the phase 3 RASolute 302 trial (NCT06625320), a landmark study presented at the 2026 ASCO Annual Meeting that has established daraxonrasib (RMC-6236) as the new standard of care (SOC) for the second-line treatment of patients with metastatic pancreatic adenocarcinoma.The discussion began by highlighting the historical context of second-line treatment, where standard chemotherapy options like FOLFOX (leucovorin calcium, fluorouracil, and oxaliplatin) or gemcitabine-based regimens typically yielded a median overall survival (OS) of only approximately 6 to 7 months. Although RAS mutations drive approximately 90% of pancreatic cancers, they were historically considered undruggable. Daraxonrasib addresses this challenge with its mechanism of action of an oral, RAS(ON), multi-selective, tri-complex inhibitor that targets the active GTP-bound state of both mutant and wild-type RAS, covering variants at codons G12, G13, and Q61.The RASolute 302 trial was an international, open-label study that randomly assigned patients with progression after 1 prior line of therapy to receive either daaxonrasib or investigator's choice of chemotherapy. In the RAS G12–mutated subpopulation of patients, daraxonrasib generated a higher median OS compared with chemotherapy. Similar benefits were observed with daraxonrasib in the overall population, where the median progression-free survival nearly doubled.Drs Armstrong and Tawagi emphasized that the toxicities associated with daraxonrasib are highly clinically relevant and distinct from the myelosuppression seen with chemotherapy. Key adverse effects (AEs) include dermatologic events, diarrhea, and stomatitis. Management of these AEs is critical; the hosts recommended the use of prophylactic oral antibiotics and topical corticosteroids to manage rash, alongside standard oral care for mucositis. Despite being associated with these AEs, daraxonrasib was better tolerated than chemotherapy, with a low treatment discontinuation rate due to AEs.Daraxonrasib is currently accessible in the US through an Expanded Access Program and is undergoing accelerated review for full FDA approval. The experts noted that the agent is being further investigated in the frontline setting through the phase 3 RASolute 303 trial (NCT07491445) and in the adjuvant setting via the phase 3 RASolute-304 trial (NCT07252232), potentially expanding the agent's effect across the continuum of pancreatic cancer care.

GTP hosts Steve Lowery and Yvonne Godfrey delve into the riveting case of Donald Clark vs. the State of Iowa with guest Mel Orchard from the Spence Law Firm. They explore the wrongful conviction of Donald Clark, a school counselor accused of sexual assault in 2009, and the subsequent legal malpractice case against his public defender for inadequate representation. The discussion highlights the significant emotional and physical toll on Clark during his six and a half years in prison, the courtroom strategies employed, and the eventual $12 million verdict for emotional distress.   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   Case Details: The case revolves around a legal malpractice action against a state public defender, who represented a client convicted of sexual abuse. The client, Donald Lyle Clark, was convicted and sentenced to prison. The conviction was affirmed on appeal. However, in postconviction proceedings, the court determined that Clark's defense counsel had provided ineffective assistance and ordered a new trial. The state declined to prosecute, and Clark filed a civil action for legal malpractice against the state as the lawyer's employer. The district court granted partial summary judgment, holding that the finding of ineffective assistance in the postconviction proceedings established counsel's negligence as a matter of law. The jury found the lawyer negligent and awarded Clark $12 million in emotional distress damages. The Supreme Court of Iowa reversed the judgment for emotional distress damages. The court clarified that to recover emotional distress damages for legal malpractice, the plaintiff must prove more than negligence. The court held that the plaintiff must prove by a preponderance of clear, convincing, and satisfactory evidence that the criminal defense attorney acted with willful and wanton disregard for the client's rights or safety. The court concluded that the district court erred by instructing the jury that negligence was sufficient. The case was remanded for further proceedings consistent with this opinion. (Source)   Guest Bio: Mel Orchard Mel Orchard is a trial lawyer, trying cases in the courtrooms across America, for the past 27 years. Mel has litigated and/or tried hundreds of cases in his career and has recovered hundreds of millions of dollars in settlement and verdicts for his clients. During his trial career, Mel has been a part of record-breaking civil jury verdicts in various jurisdictions (Wyoming, Arizona, and Iowa). He has also devoted significant time to pro bono work through Lawyers and Advocates for Wyoming, and many local and national charities. In addition to preparing for trial or being in trial, Mel was a senior faculty member and board member at the Trial Lawyer's College in Wyoming and was recently selected to join the Board. Mel also lectures and presents to various legal organizations throughout the country including Bar Associations, Leadership Organizations and has taught Judicial Ethics to various groups of judges. He was Chairman for the Wyoming Commission for Judicial Conduct and Ethics where he served as a member for six years after appointment. Read Full Bio   LISTEN TO PREVIOUS EPISODES & MEET THE TEAM: Great Trials Podcast Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production   Show Sponsors: Harris Lowry Manton LLP - hlmlawfirm.com   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

Join this channel to get access to perks - custom emojis, member lives, and access to the auction listings: https://www.youtube.com/channel/UCJoP2q6P8mWkBUMn45pgyAA/join   Jessica Hare - Hare Hollow Farm - Altus, OK Harehollowfarm.com Morph Market -  https://www.morphmarket.com/stores/hare_hollow_farm/ Facebook -  https://www.facebook.com/Hare-Hollow-Farm-113861266980541 Instagram -  https://www.instagram.com/hare_hollow_farm/ Youtube -  https://www.youtube.com/@unmeinohi

This week, your hosts Steve Lowry and Yvonne Godfrey interview Michael Levine of Rappaport, Glass, Levine & Zullo LLP (https://www.rglzlaw.com/)   Remember to rate and review GTP in iTunes: Click Here To Rate and Review   Episode Details: Michael Levine -- a partner at Rappaport, Glass, Levine & Zullo LLP known as "Motorcycle Mike" -- explains how he secured justice for 33-year-old air traffic controller Kevin Barrett, who endured a painful through-the-knee amputation after a pick-up truck collided with his motorcycle and crushed his right leg. The driver of the truck abruptly cut off Kevin, who was going 10 miles per hour over the speed limit, while making a left turn. Kevin uses a prosthetic limb as a result of this catastrophic injury. A Suffolk County, New York jury returned a $5,750,000 verdict, assigning 63% of the negligence to the defendant.   Click Here to Read/Download the Complete Trial Documents   Guest Bio: Michael Levine   Michael Levine is, without a doubt, the prime example of a “Go-Getter”. In over 35 years Michael has never stopped chasing after perfection, and his reputation and record are a shining reflection of this. If you're looking for a personal injury attorney who is a rare combination of experience, hard-charging, tactical, spirited, and unfailingly caring, you've found him.   At RGLZ we sometimes wonder how Michael finds the time and energy to do everything he does. He lectures often on his areas of expertise before the bar associations of Suffolk and New York State, serves on the Grievance and Judicial Screening committees for those bar associations, is on the board of directors of the Suffolk County Bar Association, writes articles for legal journals, has served as the President of the more than 4000 member strong New York State Trial Lawyers' Association, is Mayor of his home town of Old Field, NY,  and still finds time to be an active part of the Long Island motorcycle community as Motorcycle Mike Esq.   This is all on top of a thriving practice here at RGLZ, where Michael handles litigation in numerous types of personal injury cases including motorcycle accidents, auto accidents, truck accidents, premises liability accidents, construction accidents, and railroad and subway accidents. He is also a friend of labor unions, taking cases for the Transit Workers Union and other large unions in New York.   Despite this nearly insane workload, Michael Levine is also regarded as a true friend to his clients. He prides himself on providing round-the-clock access for his clients, regularly taking their calls personally at all hours of the day. This is backed up by the fact that, in his entire career, Michael Levine has never had a grievance filed against him, and many of his clients remain friends to this day. There simply aren't many attorneys out there who can make a claim like that. Despite Michael's dedication to improving both himself and his profession as a whole, his clients always come first, and his priorities are always simple.   “In my time as a personal injury attorney, I've seen almost all there is to see. A large part of my life is coming into other people's lives in what is likely their worst moments; and it's tough. It hurts to see people in these situations. But at the same time, it's what drives me. I know that I can make a difference for these people. And if, at the end of my time with them, I can see them smile, and feel just that little bit better… That's what I do all of this for.”   Read Full Bio LISTEN TO PREVIOUS EPISODES & MEET THE TEAM: Great Trials Podcast Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production   Free Resources: Stages Of A Jury Trial - Part 1  Stages Of A Jury Trial - Part 2

In this episode of The Logbook, our History of Motorsports Series, Mark Raffauf traces IMSA's nearly 60-year evolution from John Bishop and Bill France's founding phone call to today's hybrid era. Raffauf recounts IMSA's early experiments with Formula Fords/Vees, the shift to closed-wheel GT racing, the creation of Camel GT, RS/“little car” series on street tires, and All American GT, plus innovations like road-racing stock cars, Group 5, and GTP prototypes developed with the ACO to keep cars available to private teams. He highlights major manufacturers and iconic cars (Porsche 935/962, BMW CSL, Greenwood Corvette, Mazda rotary, Audi 90 GTO, Jaguar, Nissan, Toyota, Ferrari 333 SP), the growth of street races and Firestone Firehawk, rising speeds and safety limits, ownership turmoil, the IMSA split into ALMS and Grand-Am, and the eventual merger leading to today's booming IMSA with strong OEM support and advanced hybrid prototypes. ===== (Oo---x---oO) ===== 00:00 Meet Mark Raffauf 02:14 IMSA Origins Bishop & Bill France 03:55 First Races Open Wheel 04:53 Closed Wheel Camel GT, Small Cars w/ Street Tires 06:32 All American GT Era 10:42 American Challenge Stock Cars 11:39 Group 5 Turbo Monsters 13:48 GTP Arrives Daytona 1978 15:20 935 Evolution And Innovation 18:11 Privateers Payout Philosophy and the Road America Breakthrough 22:29 Lola T600 Ground Effects 26:14 Audi 90 GTO Quattro 28:28 Jaguars Take Over 29:11 Street Races: Miami and the Downtown street racing boom! 29:42 Wild tech experiments 30:13 GTP rules vs Group C 33:06 Firehawk showroom racers 34:47 Night racing survival 36:54 When speed got dangerous 38:46 Ownership turmoil and exports 40:57 GTP peak and aero wars 44:49 World Sports Car era 46:46 Ferrari 333SP dominance 48:11 Split into Grand Am and ALMS 50:57 Merger to modern IMSA 51:49 Hybrids and today's grid 53:53 Closing remarks and sponsors ==================== The Motoring Podcast Network : Years of racing, wrenching and Motorsports experience brings together a top notch collection of knowledge, stories and information. #everyonehasastory #gtmbreakfix - motoringpodcast.net More Information: Visit Our Website Become a VIP at: Patreon Online Magazine: Gran Touring Follow us on Social: Instagram This episode is part of our HISTORY OF MOTORSPORTS SERIES and is sponsored in part by: The International Motor Racing Research Center (IMRRC), The Society of Automotive Historians (SAH), The Watkins Glen Area Chamber of Commerce, and the Argetsinger Family - and was recorded in front of a live studio audience.

This week your hosts Steve Lowry and Yvonne Godfrey interview Frank Mangiaracina of Kline & Specter PC (https://www.klinespecter.com/).    Remember to rate and review GTP in iTunes: Click Here To Rate and Review   Episode Details: Philadelphia-based personal injury attorney Frank Mangiaracina with Kline & Specter PC discusses how he secured justice for David Coryell, a motorcycle driver involved in an automobile wreck with a delivery driver employed by a Domino's franchise. On July 27, 2016, defendant Steven Morris was driving a delivery vehicle to deliver Domino's food when he made a sudden left turn into oncoming traffic, crashing his vehicle into David and his motorcycle. David suffered severe physical and emotional injuries from this incident. After numerous operations, he was left with the decision to either amputate his left leg or experience permanent and progressive pain. Despite the defense's attempts to claim that Domino's did not have control over a franchisee's operations and therefore could not be held accountable for the actions of a franchisee's employee, Mangiaracina established that Domino's and the franchisee have a “master-servant relationship,” arguing that Domino's did, in fact, have control over the franchisee and therefore should be held responsible. The jury agreed, and on August 13, 2021, a Philadelphia County jury returned a $2,009,553 verdict in favor of plaintiff David Coryell.     Click Here to Read/Download Trial Documents   Guest Bio: Frank Mangiaracina Frank Mangiaracina focuses his practice on catastrophic personal injury. He is a staunch advocate and proven trial lawyer who helped compile more than $60 million in recoveries in the five years before coming to Kline & Specter.  Most recently, in a COVID-era trial during the summer of 2021, Mangiaracina won a $2.1 million verdict against Domino's Pizza for a client who suffered severe and permanent injuries to his leg when his motorcycle was struck by a delivery driver. As co-lead counsel at trial, Mangiaracina gave a closing argument that helped convince the jury that Domino's was responsible for the actions of a franchisee.  He was also co-counsel in litigation that achieved a $44 million pre-trial settlement in a product liability case for an oil rig worker who was left a quadriplegic after he was struck by a falling light fixture.  In medical malpractice cases, among others, Mangiaracina helped win settlements of $5.5 million, $5 million and $3.5 million for, respectively, failures to timely diagnose stroke, diagnose and treat sepsis and to treat an aortic aneurysm.  These recoveries were made with Mangiaracina's prior firm, Sheridan & Murray LLC in Fort Washington, Pa. He also worked as an attorney at Berger & Montague in Philadelphia and as a law clerk with the Philadelphia firm of Saltz, Mongeluzzi & Bendesky.  Because of his litigation success, Mangiaracina has been named a Pennsylvania Rising Star by Super Lawyers for four consecutive years (2019-2022). The independent lawyers survey group recognizes the top 2.5 percent of attorneys in the state who are 40 or younger.  Mangiaracina earned his law degree at the Temple University Beasley School of Law, where he graduated magna cum laude, in the top five percent of his class and was a member of the Order of the Coif honor society. He was, simultaneously, staff editor for the Temple Law Review and a member of Temple's renowned National Trial Team, which placed in the semifinals of the National Institute of Trial Advocacy's “Tournament of Champions,” an invitation-only competition.  At Temple, Mangiaracina won several awards and scholarships, including the Integrated Trial Advocacy Graduation Award, the Benjamin and Natalie Levin Memorial Scholarship, the Class of 1978 Scholarship and the Faculty Law Scholarship. Read Full Bio   LISTEN TO PREVIOUS EPISODES & MEET THE TEAM: Great Trials Podcast Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

It's The Week In Sports Cars show featuring DailySportsCar.com's Stephen Kilbey and Marshall Pruett on Acura's upcoming exit from GTP, the Long Beach IMSA race, and the WEC opener at Imola. Every episode is graciously supported by the Justice Brothers and TorontoMotorsports.com.  NEW show stickers and memorabilia: ThePruettStore.com If you'd like to join the PrueDay podcast listener group, send an email to pruedayrocks@gmail.com and you'll be invited to participate in the Discord chat that takes place every day and meet up with your new family at events. Play on Podbean.com: https://marshallpruett.podbean.com/ Subscribe: https://marshallpruettpodcast.com/subscribe Join our Facebook Group: https://www.facebook.com/MarshallPruettPodcast [WSC]

ZEGAMA AIZKORRI 2026: CÓMO PREPARARLA: LA VISIÓN DE RODRIGO LADERA y SANDRA YAGÜE. Nuestra sección ZEGAMA AIZKORRI se prepara ya para traeros en vivo un año más las carreras de montaña del Goierri, desde la encantadora villa de montaña guipuzcoana.La próxima edición será el 17 Mayo 2026: Nuestros patrones Rodri Ladera y Sandra Yague estarán allí. Ella compitiendo tras su oro en GTP 2025, el como entrenador. Repasamos su plan  de preparación en dos artículos complementarios, más un especial en radio trail con Mayayo. Rodrigo: Desde un punto de vista de entrenamiento, introducir Zegama dentro de una preparación de 100 millas implica ajustar el proceso sin perder lo que ya está construido. La estrategia pasa por abrir un bloque específico de cuatro semanas donde el volumen baja ligeramente, sobre todo en las semanas más cercanas a la carrera, mientras la intensidad aumenta de forma progresiva. Todo ello manteniendo el estímulo aeróbico que sostiene la base. El objetivo es afinar a Sandra Yagüe, ganadora del Gran Trail de Peñalara 100k en 2025 y atleta de ultradistancia, para responder a un esfuerzo más corto, más intenso y con mayor componente técnico.  Llegar a una prueba como Zegama dentro de una preparación de 100 millas tiene que ver con ajustar el estímulo en cada fase, entender cómo responde el cuerpo y mantener coherencia en todo el proceso. Ahí es donde la planificación se vuelve realmente específica. Donde los detalles empiezan a tener peso. Este tipo de preparación requiere una lectura continua de la atleta, apoyada en datos, en experiencia de campo y en la capacidad de ajustar el entrenamiento según lo que va ocurriendo. Sandra:  En Zegama-Aizkorri voy a correrd esde un estado en el que pueda sostenerme dentro de mí durante toda la carrera: regular la salida, sostener la intensidad y llegar a la segunda mitad con capacidad de seguir respondiendo. Con ganas. Con las piernas y también con todo lo demás. Zegama será exigente. La VDA será larga. Ambas forman parte de un mismo proceso donde el objetivo trasciende el resultado técnico. Mi preparación busca demostrar que existe una alternativa a la épica del agotamiento: una forma de habitar la montaña donde la respiración y la autorregulación organizan el movimiento, y no al revés.  Esta perspectiva,que nace de mi trabajo en Regulación NeuroCupacional™ yen Respiracion Neuroepigenetica®, es la que vertebra tanto misentrenamientos como los programas que comparto con quienes buscan recuperar esamisma coherencia. Al final, la montaña nos devuelve exactamente el estado en elque estamos, sin negociar con quién creemos ser. El verdadero éxito en la líneade salida es, simplemente, haber aprendido a escucharla.  Sergio: Gracias a Sandra y a Rordigo, por compartir vuestra preparación rumbo a Zegama...y por los buenos ratos compartidos subiendo a Bola del Mundo con un ambiente invernal desde Cercedilla como aperitivo de esta entrevista.  Sergio Mayayo #carrerasdemontaña #radiotrail

ZEGAMA AIZKORRI 2026: CÓMO PREPARARLA: LA VISIÓN DE RODRIGO LADERA y SANDRA YAGÜE. Nuestra sección ZEGAMA AIZKORRI se prepara ya para traeros en vivo un año más las carreras de montaña del Goierri, desde la encantadora villa de montaña guipuzcoana. La próxima edición será el 17 Mayo 2026: Nuestros patrones Rodri Ladera y Sandra Yague estarán allí. Ella compitiendo tras su oro en GTP 2025, el como entrenador. Repasamos su plan  de preparación en dos artículos complementarios, más un especial en radio trail con Mayayo.https://go.ivoox.com/rf/172166172Rodrigo: Desde un punto de vista de entrenamiento, introducir Zegama dentro de una preparación de 100 millas implica ajustar el proceso sin perder lo que ya está construido. La estrategia pasa por abrir un bloque específico de cuatro semanas donde el volumen baja ligeramente, sobre todo en las semanas más cercanas a la carrera, mientras la intensidad aumenta de forma progresiva. Todo ello manteniendo el estímulo aeróbico que sostiene la base. El objetivo es afinar a Sandra Yagüe, ganadora del Gran Trail de Peñalara 100k en 2025 y atleta de ultradistancia, para responder a un esfuerzo más corto, más intenso y con mayor componente técnico.  Llegar a una prueba como Zegama dentro de una preparación de 100 millas tiene que ver con ajustar el estímulo en cada fase, entender cómo responde el cuerpo y mantener coherencia en todo el proceso. Ahí es donde la planificación se vuelve realmente específica. Donde los detalles empiezan a tener peso. Este tipo de preparación requiere una lectura continua de la atleta, apoyada en datos, en experiencia de campo y en la capacidad de ajustar el entrenamiento según lo que va ocurriendo.Sandra: En Zegama-Aizkorri voy a correr desde un estado en el que pueda sostenerme dentro de mí durante toda la carrera: regular la salida, sostener la intensidad y llegar a la segunda mitad con capacidad de seguir respondiendo. Con ganas. Con las piernas y también con todo lo demás. Zegama será exigente. La VDA será larga. Ambas forman parte del mismo proceso. Zegama será exigente. La VDA será larga. Ambas forman parte de un mismo proceso donde el objetivo trasciende el resultado técnico. Mi preparación busca demostrar que existe una alternativa a la épica del agotamiento: una forma de habitar la montaña donde la respiración y la autorregulación organizan el movimiento, y no al revés. Esta perspectiva, que nace de mi trabajo en Regulación NeuroCupacional™ y en Respiracion Neuroepigenetica®, es la que vertebra tanto mis entrenamientos como los programas que comparto con quienes buscan recuperar esa misma coherencia. Al final, la montaña nos devuelve exactamente el estado en el que estamos, sin negociar con quién creemos ser. El verdadero éxito en la línea de salida es, simplemente, haber aprendido a escucharla. Sergio: Gracias a Sandra y a Rordigo, por compartir vuestra preparación rumbo a Zegama...y por los buenos ratos compartidos subiendo a Bola del Mundo con un ambiente invernal desde Cercedilla como aperitivo de esta entrevista. Sergio Mayayo.#carrerasdemontaña #radiotrailConviértete en un supporter de este podcast: https://www.spreaker.com/podcast/radio-trail-carreras-de-montana-mayayo--4373839/support.

This week, your hosts Steve Lowry and Yvonne Godfrey interview Randall Sorrels and Alexandra Farias-Sorrels of Sorrels Law (https://sorrelllawfirm.com/)   Remember to rate and review GTP on iTunes: Click Here To Rate and Review   Case Details: Husband-and-wife trial team Randall Sorrels and Alexandra Farias-Sorrels of Sorrels Law share how they secured justice for an airline wing walker who was struck by a fueling truck and catastrophically injured. On September 7, 2019, Ulysses Cruz donned his yellow vest and held bright orange wands to guide a United Airlines plane when Allied Aviation Fueling Company truck driver Reginald Willis struck Ulysses with the vehicle. Ulysses was paralyzed on impact, underwent spine stabilization surgery and suffered an accident-related stroke that affected the right side of his body and the left side of his brain. In the courtroom, award-winning trial lawyers Randall and Alexandra Sorrels sparred against the defense attorney, who attempted to place blame on United Airlines and to label Ulysses as a wing walker with a lack of "situational awareness." The Sorrels Law duo countered with proof that Reginald Willis violated Allied Aviation Fueling Company's policies by continuing to drive while blinded by the sun. On October 25, 2021, a Harris County, Texas jury found Allied Aviation Fueling Company 70% responsible and driver Reginald Willis 30% responsible for the accident and awarded Ulysses Cruz and his family a $352.77 million verdict, which is believed to be the largest actual damages verdict in U.S. history for an injured worker.    Click Here to Read/Download the Complete Trial Documents Guest Bios: Randy Sorrel Randy Sorrels holds the unique distinction of being the only Texas board-certified plaintiffs' lawyer ever to have been elected to serve as President of the State Bar of Texas and selected as one of the Top 100 lawyers in the state by Texas Super Lawyers magazine. His passionate representation of clients and lawyers has garnered statewide recognition and numerous prestigious awards. Randy and his partner/wife obtained what is believed to be the largest actual damages verdict in United States' history for an injured worker — $352.7 million – in a fully contested jury trial. In short, whether it is in the courtroom or in the boardroom, Randy has an unparalleled track record of success for his clients and the organizations he leads. As a leader, Randy was voted by Texas lawyers to become the 2019-2020 State Bar President by the widest margin of victory in State Bar history. During his presidential service, he traveled Texas solidifying his reputation for helping not only those who hire him, but also helping fellow lawyers. His network of friends and relationships throughout the state is vast, and he is often hired by lawyers who are in need of representation. As a zealot advocate for his clients, Randy holds four board certifications including in Personal Injury Trial Law, Civil Trial Law and Civil Trial Advocacy from the Texas Board of Legal Specialization and the National Board of Trial Advocacy. And in a peer selection process, for the last 14 years he has been named one of the Top 100 lawyers in the state. He is sought after by the nationwide and local media for legal analysis, commentary and perspective. Randy's success in the courtroom is also well-known throughout Texas and the nation. He has taken dozens of cases to trial, securing multi-million-dollar verdicts in personal injury cases, medical malpractice cases, plant explosion cases and business lawsuits. During the time of Covid, Randy and the Sorrels Law team secured two of the largest personal injury jury verdicts in the country in high-profile cases that received media attention worldwide. In one of the cases, the jury returned an actual damages verdict of $352.7 million for an injured worker who suffered catastrophic injuries, while in the other the jury awarded two minor league baseball players $3.24 million. For 2022, Randy has been named the Best Lawyers® Personal Injury – Plaintiffs “Lawyer of the Year” in Houston, and has been named the Best Lawyers' Medical Malpractice Law – Plaintiffs “Lawyer of the Year” in Houston on three separate occasions. He has received some of the highest legal honors in the state, including being awarded the State Bar of Texas President's Award (recognizing the one Texas Lawyer who provided the most outstanding contributions through distinguished service to the lawyers of Texas), the Judge Sam Williams Award (recognizing the Texas lawyer who provides the greatest contribution to both local bars and the State Bar of Texas), and the Houston Bar Association President's Award (recognizing significant contributions to an HBA program). Early in his career, Randy was honored with the Woodrow B. Seals Outstanding Young Lawyer of Houston Award (recognizing the one young Houston lawyer who exemplified significant professional traits both inside and outside the practice of law). He started his career as a lawyer at the internationally acclaimed Fulbright & Jaworski (now Norton Rose Fulbright). Read Full Bio   Alex Farias-Sorrels Alex Farias-Sorrels is a passionate litigator, who left “Big-Law” to pursue her desire to help people who have been wrongly injured. She treats her clients like family and handles every aspect of her cases as if she were handling them for her own mother, father, sister, or brother. A Latina, native Houstonian, and bilingual lawyer, Alex is proud to bring a woman's touch to personal injury law. Alex attended both undergrad (2007) and law school (2010) at the University of Miami in Coral Gables, graduating with honors.  While graduating in the top 10% of her law school class, Alex also interned for the appellate division of the U.S. Attorney's office in Houston and for Legal Services of Greater Miami. After law school, as part of a fellowship program, Alex served as a full-time law clerk for U.S. Bankruptcy Judge Jeff Bohm for a year.  At the same time, and on a part-time basis, she received her first exposure to plaintiffs' work at a respected personal injury law firm in Houston where she handled personal injury cases and business disputes.  In her second year of practice, she worked as a briefing attorney for the Supreme Court of Texas, clerking for Justice David Medina. There, she assisted the Court in assessing complex state law issues and also helped draft the Court's opinions. After her term at the Court, Alex joined the international law firm Morgan, Lewis & Bockius, a Philadelphia-based firm with over 2,200 lawyers worldwide.  Alex practiced in the firm's Houston litigation section and focused mostly on complex commercial cases and insurance recovery cases.  She also handled products liability and personal injury cases, including aircraft crashes.  She served as first-chair counsel in more than ten trials, and was often called on to assist on thorny appellate issues.  Alex's largest victory came in an arbitration award, as she was instrumental in securing an almost $300 million arbitration award on behalf of a major Fortune 500 company on a fraudulent transfer claim.   Alex and her husband Randy Sorrels have a young son, Houston Alexander, who is bilingual, and keeps them busy when they are not working.  They also have two rescue dogs – Gio and Luna.  Alex is active in the bar, currently serving as a board member on both the Texas Bar Foundation and the Houston Young Lawyers Foundation. Read Full Bio   Show Sponsors: Legal Technology Services - LegalTechService.com Harris Lowry Manton LLP - hlmlawfirm.com   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2  

This week Steve and Yvonne interview Natalie Woodward of Warshauer Woodward Atkins (https://warlawgroup.com/) and Dax López of DelCampo Grayson Lopez Attorneys at Law (https://dglattorneys.com/).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Guest Bios: Natalie Woodward Anyone who meets Natalie Woodward feels like they have known her their entire life. It is this ability to put people at ease that makes her such an effective trial lawyer. Natalie secured a $77.7 million psychiatric malpractice verdict in September 2022 for the Carusillo family who's son was forced out of a mental health facility without his medication in 2017. Watch the News Nation interview about the case. In 2010, she tried her first jury trial as lead counsel in a wrongful arrest case and secured a $1 million verdict which is the largest verdict of its kind in Georgia history. In 2021, she was interviewed about this trial. https://www.podbean.com/ew/pb-e8jnd-101dc94 Her cases have made international and national news including her fight to protect the rights of children on social media. https://youtu.be/cfGYpv8iKIE In 2014, she argued before the Georgia Court of Appeals to obtain increased protection for children targeted on social media. https://caselaw.findlaw.com/ga-court-of-appeals/1680364.html Natalie has also led the fight to secure justice for victims of childhood sexual abuse. Natalie is a proud native of Powder Springs, Georgia and is a venerable “Double Dawg.” She received undergraduate degrees in Journalism and Political Science from UGA and then graduated from UGA Law in 2002. While in law school, she was a member of the 2001 Champion Intrastate Moot Court Team, President of her Second Year Class and Chair of the Moot Court Board. Natalie serves on the Executive Committee for the Georgia Trial Lawyers Association and the Bench and Bar Committee of the State Bar of Georgia. She has been recognized by her peers as one of the best lawyers in the State for the past six years and was selected as one of the Best Young Lawyers in Georgia by Atlanta Magazine. Read Full Bio Here Dax López For nearly 11 years, Dax served as a judge on the State Court of DeKalb County where he presided over complex criminal and civil matters.  As only the second Hispanic judge on a court of record in the history of Georgia, Dax was known to be an efficient, fair, and just jurist who earned the respect of lawyers and litigants alike. A native of Ponce Puerto Rico, Dax attended Vanderbilt University and Vanderbilt Law School where he was an editor on the Vanderbilt Journal of Transnational Law and the president of the Vanderbilt Bar Association.  After law school, Dax served as the law clerk for federal judge Hector M. Laffitte in the Federal District Court for the District of Puerto Rico. Prior to his appointment to the bench, Dax was a trial lawyer at three prestigious law firms in Atlanta specializing in complex civil matters, business litigation, product liability, and employment law. Throughout his legal career, Dax has received numerous recognitions.  Dax has been named as one of the Top Fifty Industry Leaders by the Atlanta Business Chronicle, as among Georgia's Legal Elite by Georgia Trend magazine, and as a Rising Star in 2009 and 2010 by the SuperLawyer Magazine.  In 2010, Mundo Hispanico named Dax to be the Funcionario Destacado del Aňo.  In 2011, Dax was named by Georgia Trend Magazine to be among the best and brightest 40 Under 40 and by The Fulton Daily Report to be among those in the legal profession who were “On the Rise.”  He is also the recipient of the Justice Benham Community Service Award. Dax served on the Board of the Georgia Association of Latino Elected Officials for 15 years, and as President of the Georgia Hispanic Bar Association from 2006-2008.  He is also a past president of the Cooper Inn of Court.  Currently, he is a Trustee on the Board of Leadership Georgia, a member of the Board of Councilors for the American Jewish Committee, and a member of the Anti-Defamation League's regional board.   He is also a member of the State Bar of Georgia's Board of Governors and a member of the Standing Committee of Interpreters. In 2015, President Barack Obama nominated Dax to a vacant seat on the Federal District Court for the Northern District of Georgia.  Unfortunately, Dax did not receive a hearing in the U.S. Senate and his nomination expired at the end of President Obama's term. Read Full Bio   Show Sponsors: Legal Technology Services - LegalTechService.com Harris Lowry Manton LLP - hlmlawfirm.com   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

A shop burned down. There's beef inside Porsche's factory team. And a transporter got arrested for joyriding someone's brand new 911. This week on P-car Talk, Mike and Aaron open with some real news from the South Florida car community — Arnage Motorsports, owned by their close friends Cory and George, lost their entire shop in a fire. GoFundMe link is in the description. These are good people and the community needs to show up for them. Then they break down Porsche's Sebring sweep — first, second in GTP, Manthey wins its class. Great weekend on paper. But there's post-race drama between the number 6 and number 7 cars that makes the press conference worth watching. Team orders, a lead change that wasn't authorized, and two teammates who are very publicly not on the same page. And then the one you'll be talking about: a Florida transporter decided a new customer's 911 was his personal weekend car. He got caught. He got arrested. But it opens up the entire conversation about how broken the car shipping industry really is — and whether driving the car home yourself is always the right call. GoFundMe for Arnage Motorsports: https://gofund.me/d87d9f93a Follow us: @pcartalk | pcartalk.com | Patreon.com/pcartalk Kimchi Crew: Steve, Leslie, Chris, Ken, Aaron, Sean, and Nik

In this powerful episode, Elijah Murrell sits down with Mohamad Faridi to share his incredible journey from growing up in Iran to encountering Jesus Christ.Raised in a culture centered on martyrdom, sacrifice, and striving to please God, Mohamad did everything he was taught—yet still found himself empty and without assurance. Despite his devotion, his prayers felt unanswered, and his efforts were never enough.Everything changed when he heard the message of Jesus.In this conversation, Mohamad opens up about what it was really like growing up in Islam, the weight of trying to earn God's approval, and the moment he realized that Jesus had already done what he was striving for. He also shares his perspective on a major question in today's culture: Does the Quran truly make America better?This is a raw and eye-opening testimony about faith, truth, and the freedom found in Christ.Get Mohamad's book, "Forsaking My Father's Religion"https://iranchristians.org/books/WAYS TO CONNECT WITH ELIJAH

A 0-0 draw at home to Leicester saw a depleted Watford side's hope of the play-offs fall away. 7 point gap with 7 games to play being deemed too high of a mountain to climb for Still's young hornets.Ned and James break down the game, the struggling squad, the growing injury list and a standout performance from Egil Selvik.They then go on to discuss where the season has truly gone wrong, deciding very quickly it was not simply down to a 0-0 draw at home to Leicester which ultimately sealed our championship status in 2026/27. Too many draws? unable to break down poor opposition?All this before a game of GTP which could decide the season.We hope you enjoyed!Let us know your thoughts!! Follow us on Twitter! @yellowsqurdpodFollow us on Instagram! @yellowsquaredpodFollow us on TikTok! @yellowsquaredpod

In this episode of Greater Than Podcast, Elijah Murrell sits down with Annette Capps to talk about how her father, Charles Capps, discovered the power of words and how it completely changed his life.From a place of debt, sickness, and negative thinking, everything shifted when he realized the impact of what he was saying. Annette shares the story of how that revelation came and how the Word of God began to reshape his life from the inside out.They unpack what it really means to call things that are not as though they were, how faith works in both the heart and the mouth, and why aligning your words with God's Word is so important for every believer.This conversation will challenge you to examine what you're saying and encourage you to live by faith in a practical, everyday way.Get Charles and Annette's devotional, Shaping Tomorrow:https://cappsministries.com/products/shaping-tomorrow?srsltid=AfmBOorOeGJIIWZpH8kZEWXoIkUm5k_SlvM2WjymeRHNaH8As-gzhf3VWAYS TO CONNECT WITH ELIJAH

This week Steve and Yvonne interview Anthony Elman & Frederick Joseph of Elman Joseph Law Group, LLC (https://www.elmanlaw.com/).    Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Guest Bios: Anthony Ellman Anthony (Tony) Elman is the Lead Trial Attorney of the Elman Joseph Law Group, LLC. He has been named a "Super Lawyer" by Thomson Reuters each year from 2016-2022. This "Super Lawyer" designation is granted to no more than 5% of lawyers based upon 12 indicators of both professional achievement as well as peer recognition. Anthony Elman was born in Chicago, Illinois on October 22, 1966. He graduated with a bachelor's degree in 1988 from the University of Michigan in Ann Arbor, went on to earn his J.D. degree in 1991 from Tulane Law School in New Orleans, Louisiana, and earned his Master of Law degree (L.L.M.) in health care law in 1994 from the DePaul Law School/Health Law Institute in Chicago, Illinois. He was admitted to the State of Illinois Bar and the General and Trial Bar of the United States District Court of North Eastern Illinois in 1992. Read the Full Bio Here   Frederick Joseph Frederick is a partner and trial lawyer for the Elman Joseph Law Group, LLC.  He was named to the 2021 & 2022 "Rising Stars" group of lawyers by Thomson Reuters as part of their "Super Lawyers" awards.  This "Rising Stars" designation is for those under 40 years old or who have been practicing law for 10 years or less and is granted to the Top 2.5% of lawyers.  The designation is based upon 12 indicators encompassing both professional achievement and peer review. The Elman Joseph Law Group concentrates on Illinois personal injury lawsuits involving car, truck, SUV, motorcycle, bicycle, and pedestrian accident injuries. The firm also handles cases involving premises liability injury cases (including "slip & fall" accidents), workplace accidents, injuries and accidents that occur in nursing homes, and other situations where injury or death has resulted due to the negligence or intentional actions of another person. Frederick prides himself on his success rate at arbitration and at trial. Like other lawyers at the Elman Joseph Law Group, LLC, he is unwilling to just "settle" cases by accepting inappropriate offers from the insurance companies. Among his accomplishments are the results he achieved in two Cook County car accident cases. Mr. Joseph has obtained the highest jury verdict awards in two separate Cook County municipal division courtrooms in 2018. Both verdicts are more than double the amount of the next highest verdict in their respective courtrooms. In one car accident court trial, the verdict was 12 times the final offer from the defense attorney; in the other lawsuit, the verdict was over 5 times the final offer from the defense attorney. Another example of Mr. Joseph's trial capabilities took place recently in Cook County. The plaintiff (a public school teacher) was struck after the defendant ran a red light and collided with her vehicle. The insurance company wanted to settle the case for less than the plaintiff's medical bills, and award her nothing for her pain and suffering. Mr. Joseph, unwilling to settle for that amount, took the case to trial. After closing arguments, the jury returned a verdict for his client for over four times what the insurance company was offering to settle the case. He graduated from the Purchase College Conservatory of Music, and he continued his graduate studies at Boston University. His J.D. degree is from the Loyola University Chicago School of Law. During law school, he was a member of the Dean's List, participated on the ABA Mock Trial Team, and spent two years clerking in the litigation/product liability group for a prestigious national corporate defense firm. Read Full Bio   Show Sponsors: Legal Technology Services - LegalTechService.com Harris Lowry Manton LLP - hlmlawfirm.com   Production Team: Dee Daniels Media Podcast Production   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

This week, Steve and Yvonne interview David Yarborough and William Applegate of Yarborough Applegate Law Firm, LLC (https://www.yarboroughapplegate.com/).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Case Details: Yarborough Applegate secured a landmark jury verdict against Amazon for $44.6 million, including $30 million in punitive damages, after a man was catastrophically injured in a motorcycle collision with an Amazon van on Orangeburg Road in Summerville, South Carolina. This distracted driving case marks the first time Amazon has tested with a jury the issue of whether the online retail and global logistics giant will be held responsible for injuries caused by one of its 285,000 Amazon Delivery Associates (drivers) it calls independent contractors.  Yarborough Applegate attorneys David Yarborough, Alexandra Heaton, and William Applegate, working alongside Nick Clekis of the Clekis Law Firm in Charleston, represented a motorcyclist who sustained a traumatic brain injury and numerous orthopedic injuries in September 2021 when an Amazon Delivery Associate failed to yield to the right of way and turned left directly into his path. We filed suit against the driver, the local delivery company MJV Logistics, and Amazon, Amazon Services, and Amazon Logistics Inc. Source.   Guest Bios: David Yarborough David has a history of achieving record-breaking jury verdicts and settlements for his clients. In December 2023, David and partners obtained a $44.6 million jury verdict against Amazon.com, Inc. in the first case to hold Amazon vicariously liable under an agency theory for the vicarious and negligent acts of its delivery drivers, whom Amazon claims are independent contractors. This was the largest personal injury verdict ever awarded in conservative Dorchester County and is believed to be one of the largest jury verdicts in South Carolina history in an injury case not involving death. Read more about this case here. In October 2021, David achieved the largest dram shop verdict ever in Charleston County, South Carolina, for the sale of alcohol to minors by a Sunoco gas station. David and the firm also achieved one of the top 100 jury verdicts in the United States from their $35.9 million verdict against PEPCO in conservative Montgomery County, Maryland. David has collected jury verdicts and settlements totaling hundreds of millions of dollars for his catastrophically injured clients in cases involving bad faith against insurance companies; industrial plant injuries resulting in worker deaths; product liability from automobile rollovers and industrial machine injuries; toxic chemical spills by railroad companies; pool drownings; trucking and auto accidents; nursing home and daycare negligence; dram shop and alcohol liability negligence by bars and restaurants; and negligence by retail stores, energy companies, apartment complexes, hotels, and construction contractors for job-site, balcony collapse and premises injuries. He is a member of the Charleston Chapter of the American Board of Trial Advocates (ABOTA), the South Carolina Association of Justice, the American Association for Justice, the Charleston County Bar's Mental Wellness Committee, Lawyers Helping Lawyers, and the Board of Regents of TriCounty Family Ministries. For the past twenty-five years, David has been heavily involved in mentoring and counseling people suffering from alcoholism and addiction who are seeking recovery. He places a large emphasis on giving back to the local community through free legal work and generous financial and service contributions to local charities each year. He and his wife, Jessica, are Charleston natives and have four children. Prior to founding Yarborough Applegate, David was a partner at another Charleston-based law firm, where he was part of a national trial team defending products liability cases in trials across the United States. His experience handling national litigation and having represented both plaintiffs and defendants in state and federal courts around the country provides him with a varied perspective in discovery strategy, negotiations, and trial. Read Full Bio   William Applegate With nearly twenty years of experience in the courtroom, William is a seasoned trial lawyer with a track record of success. He has successfully litigated complex cases involving toxic torts, electrocutions, police negligence, medical negligence, and premises liability, representing clients suffering from the most severe catastrophic injuries. Beyond having had numerous trial victories, he has also achieved two record-breaking verdicts, been recognized by his peers as one of the top litigators in the state, won numerous awards as a leader in the law, and has been consistently given Martindale-Hubbell's highest ranking as an AV lawyer. Beyond his experience and hard work, he is a passionate advocate for his clients, who are defined by determination and perseverance. William understands that his clients, many of whom find themselves in desperate situations following serious trauma, such as the death of a loved one or experiencing life-altering injuries, are relying on him, and he takes this responsibility personally. In 2014, William and his team represented 28-year-old paralyzed construction worker Hugo Hernandez against PEPCO (Potomac Energy and Power Company). After a two-week trial against PEPCO in Montgomery County, Maryland, the jury awarded Mr. Hernandez $35.9 million in damages in compensation for the overwhelming cost of Mr. Hernandez's future medical care as a young, C4 paraplegic as well as for his pain and suffering and loss of income. This was the largest verdict in Montgomery County history and was one of the largest verdicts in American history for an undocumented worker. In 2019, William represented an undocumented worker who was killed when electrocuted by a power line that was hidden by vegetation, which Dominion Energy had failed to maintain, and a jury returned a $21 million dollar verdict, the largest verdict in the history of Colleton County, SC. In 2021, William represented a Claflin College student who suffered a traumatic brain injury as a result of a car crash caused by a road construction defect. After a two-week trial, the jury returned a $13.1 million dollar verdict against the road contractor Archer Western and the Department of Transportation, also awarding punitive damages against Archer Western. In all three of these cases, William refused offers of millions of dollars to ensure his clients were fully compensated by a jury. William was born in Charleston, SC, and with the exception of studying abroad to become fluent in Spanish, he has remained in SC his entire life. He is a graduate of the College of Charleston and the University of South Carolina School of Law. As a law student, he received the Public Interest Law Society Grant to work in Washington, D.C., served as vice-president of the Pro Bono Board, and was a student member of the John Belton O'Neal Inn of Court. Following law school, he served as law clerk to the Honorable James R. Barber, III, of the Fifth Judicial Circuit of the State of South Carolina before starting in private practice with Motley Rice, one of the largest plaintiff's firms in the country. William has a deep commitment to South Carolina and is very involved in his community in Charleston. He serves on the board of the Historic Charleston Foundation and actively supports numerous charitable organizations, including One80 Place, in their fight against homelessness, Communities in Schools, the Coastal Conservation League, and the Southern Environmental Law Center. William is a regular speaker at various legal conferences, is a member of the American Bar Association and Charleston County Bar Association, and is an active member of the South Carolina Association for Justice. When not working, William and his wife, Lydia, enjoy raising their two children in South Carolina. Read Full Bio   Links: Yarborough Applegate IG: @yarboroughapplegate   Show Sponsors: Legal Technology Services - LegalTechService.com Harris Lowry Manton LLP - hlmlawfirm.com   Production Team: Dee Daniels Media Podcast Production   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

In this Jack Westin MCAT Podcast episode, Mike and Molly break down MCAT signaling cascades with a clear, test-focused walkthrough of G protein–coupled receptors (GPCRs). You'll learn the core GPCR structure, how GDP → GTP activation works , why signaling pathways create amplification, and how cells shut signals off with built-in termination steps.We cover the high-yield cAMP pathway in detail, including Gs vs Gi, adenylyl cyclase → cAMP → protein kinase A (PKA), plus the key ideas behind the Gq pathway (PLC and calcium signaling). We also connect GPCR signaling to common MCAT contexts like hormones, fast cellular responses, and a classic passage-style example (cholera toxin) to show how the AAMC tests cause-and-effect in pathways.In this episode, you'll learn:

Para este programa, nuestro Seyito se han infiltrado en una red de Inteligencias Artificilales. Nos trae documentos en exclusiva y una incómoda entrevista con el señor GTP, bueno llamémoslo Chat X para no revelar su identidad. Riáse usted de Will Smith en Yo, Robot y de los reporteros de guerra. Que venga Skynet con todo, que aquí los esperamos con salud y teatro!

During Race Industry Week, IMSA President John Doonan delivers a powerful, in-depth breakdown of why the International Motor Sports Association is entering “another golden era” as the countdown begins toward the 2026 season and the Rolex 24 At Daytona.Fresh off an electrifying 2025, Doonan explains how IMSA's unprecedented momentum across manufacturers, teams, fans, and partners is reshaping the global sports car racing landscape—from the explosive growth of the GTP prototype class to record OEM engagement across all categories.

No hemos ni terminado enero y vivimos un momento de máxima actividad en el calendario del motor. Más allá de la Fórmula 1, el Podcast Técnica Fórmula 1, dedica el segundo episodio de la semana a analizar competiciones clave como el Rally Dakar, el arranque del Mundial de Rallyes en Montecarlo y la inminente cita de las 24 Horas de Daytona, confirmando que la temporada 2026 ya está plenamente en marcha. Mucho motor. Con el Dakar recién concluido, este segundo programa repasa los resultados en todas sus categorías: motos, coches, Challenger, Classic y camiones. Los colaboradores realizan una valoración global de una edición especialmente exigente, marcada por la dureza del recorrido y la fiabilidad como factor decisivo. Toca hablar de los momentos más relevantes de la prueba y se analiza con detalle el desempeño de los pilotos españoles, poniendo en contexto sus resultados dentro de una competición cada vez más profesionalizada y competitiva. El foco se traslada después al Mundial de Rallyes, que inicia su temporada, como es tradición, en el precioso Montecarlo. Antes de entrar en la previa del rally, Iván Fernández repasa la composición de los equipos y las novedades en las alineaciones de pilotos. Ford, Hyundai y Toyota protagonizan el análisis de las nuevas monturas, tanto desde el punto de vista del chasis como de las decoraciones, mientras se identifican los principales cambios técnicos, también en las categorías inferiores. El Rally de Montecarlo vuelve a presentarse como un desafío único dentro del calendario, con un recorrido exigente, tramos nocturnos y diurnos, y condiciones cambiantes que ponen a prueba la capacidad de adaptación de pilotos y equipos. Así que toca hacer una buena previa, detallando los kilómetros totales, la estructura de las jornadas y los retos específicos del rally, incluyendo las novedades en cuanto a compuestos de neumáticos y el material disponible para afrontar una prueba donde la puesta a punto del coche resulta crítica… y donde el año pasado los neumáticos, como en tantas pruebas, fueron protagonistas. Mirando a Estados Unidos. El cierre del episodio mira hacia Estados Unidos, con la previa de las 24 Horas de Daytona 2026. Se destacan los puntos fuertes de esta edición y la participación española, con nombres propios como Álex Palou, que competirá junto a Scott Dixon en Acura. El repaso a la lista de inscritos refleja la magnitud del evento, con una nutrida parrilla en las categorías GTP, LMP2, GTD Pro y GTD, y la presencia de los principales fabricantes y pilotos del panorama internacional. Empezamos con un plato fuerte, está claro. Con este recorrido por el Dakar, el WRC y la resistencia americana, el episodio confirma que el automovilismo afronta un inicio de año intenso y diverso. Y el Podcast Técnica Fórmula 1 arranca su décima temporada ofreciendo una visión global del motor, conectando disciplinas y campeonatos con la misma intensidad y pasión del primer episodio. Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

We bring back our Head of Rocket League, the Grumpy Trash Player himself, nasko0406. GTP comes on with us to chat the Kingdom Hearts Series, The Legend of Zelda Series, and The Final Fantasy Series.You can find all of Grumpy Trash Player's links at channel3.gg/nasko0406 Our hosts' links can be found at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ channel3.gg/rey ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠and⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ channel3.gg/dan⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The show is Executive Produced by Channel 3 Founder Joel Willis who can be found at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ channel3.gg/joel⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Our theme song is provided by Castor Garden. Find all of their tracks on Bandcamp by simply going to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠c3.gg/castorgardenmusic⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or find all of their links at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠channnel3.gg/castorgarden⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠About Channel3.gg: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠channel3.gg⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ is social networking built from the ground up for gamers. Sure you can do all the stuff like on the old social medias like post pictures, videos, comments and the like. Channel 3 is so much more than that though. It takes the social media experience and game-ifies it. Made a great post that someone likes (1-ups) or respawns? You earn XP experience points that level you up. New levels mean chances to win tickets for physical prizes, earn digital flair for your profile, and more. Additionally there are weekly events hosted by Channel 3 that let the community unwind and kick back with a little friendly competition. Sure, you want to win but it's more about hanging out and the vibes. These events are hosted on C3's Twitch Channel and also earn XP for participants. XP can also be earned for completing quests-questions related to games and being a gamer, challenges where you go forth and complete a task in a game, rating & reviewing games and systems, creating specifically themed lists of games and more. You can find Channel 3 in both the Android and Apple App Stores or at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠c3.gg/app⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

It's The Week In Sports Cars show featuring Marshall Pruett and DailySportsCar.com's Graham Goodwin. Topics: WTH is going on at Porsche with its GTP drivers, Harry King to AO, Iron Dames out of WEC, IMSA officiating, and more! Every episode is graciously supported by the Justice Brothers, the Sports Car Championship Canada, and TorontoMotorsports.com.  NEW show stickers and memorabilia: ThePruettStore.com If you'd like to join the PrueDay podcast listener group, send an email to pruedayrocks@gmail.com and you'll be invited to participate in the Discord chat that takes place every day and meet up with your new family at events. Play on Podbean.com: https://marshallpruett.podbean.com/ Subscribe: https://marshallpruettpodcast.com/subscribe Join our Facebook Group: https://www.facebook.com/MarshallPruettPodcast [WSC]

This week Steve and Yvonne interview Brian Beckcom of VB Attorneys (https://www.vbattorneys.com/).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Case Details: The crew of the Maersk Alabama was attacked and taken hostage by Somali pirates. The events were depicted in a Hollywood blockbuster called “Captain Phillips” starring Tom Hanks. Brian and his firm countered a massive Hollywood publicity campaign that portrayed Captain Phillips as a hero and the crew as lazy layabouts, when in fact the exact opposite was true. The case resulted in a confidential settlement for each crew member. It also changed the way the shipping industry provides security to the men and women who travel in dangerous, pirate-infested waters   Guest Bio: Brian Beckcom Brian Beckcom is one of the leading lawyers of his generation. Brian's peers have voted him a Texas Super Lawyer 14 years in a row, and every single year he has been eligible. Brian is also a Board Certified Expert in Personal Injury Trial Law by the Texas Board of Legal Specialization, a recognition shared by less than 2% of lawyers. Brian has obtained hundreds of millions of dollars for his clients, and he and his law firm have obtained record-setting settlements and verdicts in a wide variety of significant legal cases. Brian is also a Computer Scientist & Philosopher. He created and hosts the popular podcast "Lesson from Leaders with Brian Beckcom." Brian is a military "brat," a purple belt in Brazilian jiu-jitsu, a single-digit golfer, a former college basketball player at Texas A&M, a four-year member of the Texas A&M Corps of Cadets, and an accomplished freshwater and saltwater fly fisherman. Brian is an honors graduate of the University of Texas School of Law. He is the author of 6 books and hundreds of articles on a wide variety of topics. Brian has successfully prosecuted many high profile cases. The national and international media has covered Brian's work on these complex cases. Read Full Bio   LISTEN TO PREVIOUS EPISODES & MEET THE TEAM: Great Trials Podcast Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

Ali Haji, CEO of American Tungsten Corp. (CSE: TUNG) (OTCQB: TUNGF) (FSE: RK90), joins me to for a financial and operations update on all the exploration, development, and rehabilitation initiatives underway; focused on bringing onshore tungsten mining and production capabilities to the United States through its derisked past-producing IMA Mine in Idaho.  We also review the recent news of an LOI signed with the US Export Import Bank to fund a processing plant onsite and the development pathway back into production by late 2026.    We start off discussing the strategic importance of this tungsten – molybdenum – silver project, and the advantages of being on patented mining claims in Idaho and the infrastructure advantages of a past-producing brownfield site at the IMA Mine.  Their team has been quite busy with ongoing development, rehabilitation, and derisking work at both the D Level and Zero Level at the Project. The next phase of diamond drilling exploration program is set to commence the end of November and will run into Q1 2026.   D Level Progress   Excavation of the access crosscut to the diamond drill stations on D Level continues and is now ~54% complete (~100ft.) with ~86ft. of excavation remaining - it is expected that the 1st diamond drill station will be reached by the end of next week; The drill rig and power packs are on site and will be mobilized underground once the drill station is expanded and bolted; In parallel, development of the access drift will continue towards the 2nd and 3rd diamond drill stations; and All work at the D Level continues to be "double shifted" by the Contractor to expedite the timeline of the Phase 1 drill program.   Zero Level Progress   Rehabilitation of the Zero Level continues, and it is estimated that the remaining visible debris area will be cleared by the end of next week; This will allow access to previously rehabilitated areas on the zero level, including new drifts around unstable areas developed by 1970s operations; At this time, American Tungsten will be able to assess what, if any, additional rehabilitation at the Zero Level may be needed to support drilling from the zero level; and Additional work staff have been secured by the Contractor to ensure that the work progress at the Zero Level is being performed in parallel with work progress at the D Level.   The upcoming Phase 2 drill program to expand the known tungsten, molybdenum, and silver mineral resources will be utilized for an updated Resource Estimate, and the upcoming Preliminary Economic Assessment (PEA) in early 2026. The Company will also be conducting a trial mining and bulk sample exercise, more metallurgical tests, and is now working towards the construction decision on a processing plant on-site; which is a substantial change and upgrade to the previously envisioned direct ship ore (DSO) business model.   Next, we discussed the news from November 6th which announced that American Tungsten has received a letter of interest from the US Export-Import Bank (EXIM) for a loan worth up to US$25.5 million, to potentially fund the mining development and milling facilities associated with the Company's IMA Tungsten Mine in Patterson, Idaho.   Ali points out that in concert with their recent capital raise for $18 million, closed on October 31st, that the company is fully funded for all upcoming rehabilitation workstreams, drill programs, economic studies, and pathway to get IMA back into production by late 2026.   We also reiterated the importance of the Letter of Intent (“LOI”), signed back on September 20th, with a prominent U.S-based offtake partner, Global Tungsten & Powders (“GTP”). Ali highlights that their agreement with GTP marks a pivotal milestone in their emergence as a leading domestic supplier of high-grade tungsten, now vetted by one of the largest tungsten processors in the world. This LOI not only affirms the robust market demand for more domestic supplies of tungsten, but also reflects the deep confidence their partners have in their technical capabilities and long-term vision to move from development into near-term production.   Ali outlined the number of additions to their management team, board of directors, and technical advisors over the last few months, and reiterated that they are continuing to work closely with government agencies to build partnerships seeking to secure key strategic partnerships and non-dilutive financing with the U.S. Department of Defense,  Department of Energy, and Defense Advanced Research Projects Agency.   This brought up the critical and strategic nature of tungsten as a defense metal, where the majority of tungsten supply is controlled by China, and why the US government is keen to develop supply chains outside of China which has placed export controls on this metal, and many other critical minerals.  Tungsten is a necessary component in a wide array of defense applications, including but not limited to the production of ammunition, armored equipment, artillery, and space exploration.  The recent media narrative around rare earth elements has inadvertently become co-mingled with completely separate critical minerals like tungsten or antimony and this has disproportionately weighed on the valuation in some critical minerals stocks, that are actually unrelated and have their own unique markets and fundamentals.  The export bans out of China with regards to some of these other critical minerals sectors are not part of the 1 year truce between the US and China, and have actually intensified.       If you have any questions for Ali regarding American Tungsten, then please email those into me at Shad@kereport.com.   In full disclosure, Shad is a shareholder of American Tungsten at the time of this recording, and may choose to buy or sell shares at any time..     For more market commentary & interview summaries, subscribe to our Substacks:   The KE Report: https://kereport.substack.com/ Shad's resource market commentary: https://excelsiorprosperity.substack.com/   Investment disclaimer: This content is for informational and educational purposes only and does not constitute investment advice, an offer, or a solicitation to buy or sell any security. Investing in equities and commodities involves risk, including the possible loss of principal. Do your own research and consult a licensed financial advisor before making any investment decisions. Guests and hosts may own shares in companies mentioned.

Tracee Dunblazier, GC-C, is a Los Angeles-based spiritual empath, shaman, and a nine-time national award-winning author and publisher. As a multi-sensitive, Tracee's blend of intuitive information combined with different modalities, has provided the opportunity for many to achieve deep healing and create the success and peace they seek in their lives. In 2020, Tracee was elected President of COVR: Coalition of Visionary Resources (the trade organization for the Mind, Body, Spirit industry). and in 2015, she founded GoTracee Publishing, which has since grown to be a nationally-awarded hybrid publisher that specializes in spiritual-healing Narrative- Nonfiction, and divination oracle decks—tools for meditation and self-discovery. Their best-selling Conquer Your Karmic Relationships: Heal Spiritual Trauma to Open Your Heart and Restore Your Soul (Aug 2020 GoTracee Pub.) from the Demon Slayer's Handbook Series, and Rainbow Warrior Activation Deck—offer light in dark places. They are game changers for those who suffer. GTP publications expand the reader's understanding of spiritual transformation and offer the knowledge one needs to live their best life. Tracee's compassionate, humorous, down-to-earth style empowers clients, readers, and listeners to address difficult topics with courage and clarity. Because of this, Tracee is consistently called upon by the media for expert commentary on spirituality and relationship dynamics.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-x-zone-radio-tv-show--1078348/support.Please note that all XZBN radio and/or television shows are Copyright © REL-MAR McConnell Meda Company, Niagara, Ontario, Canada – www.rel-mar.com. For more Episodes of this show and all shows produced, broadcasted and syndicated from REL-MAR McConell Media Company and The 'X' Zone Broadcast Network and the 'X' Zone TV Channell, visit www.xzbn.net. For programming, distribution, and syndication inquiries, email programming@xzbn.net.We are proud to announce the we have launched TWATNews.com, launched in August 2025.TWATNews.com is an independent online news platform dedicated to uncovering the truth about Donald Trump and his ongoing influence in politics, business, and society. Unlike mainstream outlets that often sanitize, soften, or ignore stories that challenge Trump and his allies, TWATNews digs deeper to deliver hard-hitting articles, investigative features, and sharp commentary that mainstream media won't touch.These are stories and articles that you will not read anywhere else.Our mission is simple: to expose corruption, lies, and authoritarian tendencies while giving voice to the perspectives and evidence that are often marginalized or buried by corporate-controlled media

Nueva edición de Weekly Quest Extra, el podcast donde los GTP te cuentan qué estsuvieron jugando el fin de semana. En esta ocasión vamos a tirarte toda la data sobre Ninja Gaiden 4, el regreso de una saga icónica. Además jugamos Vampire The Masquerade Bloodlines 2, uno de los choques de trenes del año. Estuvimos testeando un poco Power Wash Simulator 2 y también probando el reciente Tormented Souls 2. Sumate a un nuevo podcast junto a toda la comunidad!

Ali Haji, CEO of American Tungsten Corp. (CSE:TUNG) (OTCQB:DEMRF) (FSE:RK9), joins me to for a financial and operations update on all the exploration, development, and rehabilitation initiatives underway; focused on bringing onshore tungsten mining and production capabilities to the United States through its derisked past-producing IMA Mine in Idaho.   Today on October 22,  American Tungsten announced that, further to its press releases dated October 14, 2025, October 15, 2025, and October 20, 2025, it completed the first tranche of its non-brokered private placement for gross proceeds of C$16,770,510 from the sale of 6,500,198 common shares of the Company at a price of C$2.58 per Share (the "LIFE Offering") under the Listed Issuer Financing Exemption.   We start off discussing this financing, the rationale for both the timing of it, and the subsequent repricing of it lower to gain better traction and confidence with incoming institutional investors. Most importantly, we get into what these funds will enable in terms of future value creation through the ongoing rehabilitation and development work at the IMA Mine.   Next, we discussed the Letter of Intent (“LOI”) signed back on September 20th with a prominent U.S-based offtake partner, Global Tungsten & Powders (“GTP”). Ali highlights that their agreement with GTP marks a pivotal milestone in their emergence as a leading domestic supplier of high-grade tungsten, now vetted by one of the largest tungsten processors in the world. This LOI not only affirms the robust market demand for more domestic supplies of tungsten, but also reflects the deep confidence their partners have in their technical capabilities and long-term vision to move from development into near-term production.   Then Ali expanded the ongoing IMA Mine Rehabilitation Progress:   A total of 115 feet of the Zero Level access tunnel has now been successfully rehabilitated, measured from the portal entrance; with anticipated work on the zero level tunnel approximately 80% complete. Rehabilitation efforts are now within the heart of the main collapsed zone, currently estimated to span approximately 50 feet. At a September site visit the management team reviewed the Zero Level rehab work, the D Level underground workings, the historic tailings area across the road from the canyon, and the broader site area. The MSHA inspector expressed confidence in the site's progress and praised the quality of work completed. A Radon measurement taken within the tunnel yielded a zero reading, affirming a safe working environment.     Zooming back to the project level, we shifted over to the tungsten, molybdenum, and silver resources in place and the infrastructure advantages of the IMA Mine as an advanced, past producing brownfields site, located on patented mining claims in Idaho. There has been a substantial amount of capital spent over many years to advance and build the project by various mining companies, including the Bradley Mining Company, Inspiration Development Co. (subsidiary of Anglo American PLC), and American Metal Climax. There is solid infrastructure including roads, tier-1 low-cost power supply, water rights, and a mining-oriented labor force nearby, which can help fast-track this project back into production, with a low capex anticipated to be ~$20 Million.   Ali reiterated that they are continuing to work closely with government agencies to build partnerships seeking to secure funding.  He believes there is the opportunity to secure key strategic partnerships and non-dilutive financing with the U.S. Department of Defense,  Department of Energy, and Defense Advanced Research Projects Agency, and mentioned that those discussions are underway and applications were previously filed.   This brought up the critical and strategic nature of tungsten as a defense metal, where the majority of tungsten supply is controlled by China, and why the US government is keen to develop supply chains outside of China which has placed export controls on this metal, and many other critical minerals.  Tungsten is a necessary component in a wide array of defense applications, including but not limited to the production of ammunition, armored equipment, artillery, and space exploration.     There is planned drill program to expand the known tungsten, molybdenum, and silver mineral resources, and this will be utilized for an updated Resource Estimate, and the upcoming Preliminary Economic Assessment (PEA). The company will also be conducting a trial mining and bulk sample exercise, more metallurgical tests, and the company is now working towards the construction decision on a processing plant on-site, which is a change and upgrade to the previously envisioned direct ship ore (DSO) business model.   If you have any questions for Ali regarding American Tungsten, then please email those into me at Shad@kereport.com.   In full disclosure, Shad is a shareholder of American Tungsten at the time of this recording, and may choose to buy or sell shares at any time.   Click here to follow the latest news from American Tungsten

iRacing tire grief...still?; GTP to GT3 to GT4 Tires; G-Force Sim Racing; Indy NXT League Poetics.

Welcome to our motorsports podcast where we discuss F1, IndyCar, IMSA, NASCAR, our own racing adventures, and some other adventures!Denny Hamlin wins in Vegas. NASCAR heads to Martinsville next week.Supercars had its Great Race over the weekend and it was indeed a great race. The Bathurst 1000 provided some excellent entertainment with many battles that occurred over the mountain. There was a kangaroo sighting...and near miss....as well as a driver-fan interaction that made the rounds on the socials.IMSA had its season finale at Road Atlanta for the Petit Le Mans. An epic 10 hour showdown that had some thrilling strategies play out towards the end of the race that resulted in the Whelan Cadillac taking top honors in GTP. The Aston Martin Valkyrie had an impressive outing finishing 2nd and some of the fastest laps of the race in the final hours. Great progress for that car and team! Penske Porsche finished 3rd in GTP and that was enough to secure them the GTP championship. In GTD Pro it was Paul Miller BMW that won its class for Petit Le Mans but in 2nd and 3rd it was Corvette Racing where they were able to claim the championship for its class.Coming up this weekend: NASCAR is at Talladega, MotoGP is at Phillip Island, F1 is at COTA, ELMS is at Portimao and IGTC is at Indy.

This week, Steve and Yvonne interviewed Lee Hunt of Hunt Law Firm (https://huntlaw.com/).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Case Details: James Razo, age 55, suffered a spinal cord injury while working on Only the Brave, a movie about a group of elite hotshot firefighters filmed in 2016. Mr. Razo was transporting camera equipment, which tipped over, crushing him. He suffered a spinal cord injury, internal injuries, and brain damage.    Guest Bio: Lee Hunt You want to know more about your lawyer than whether he is capable of handling your case. By the end of the case, you and your lawyer better trust each other, know each and honestly care about each other. My belief is that to help a person in a legal crisis, I must know you as a person – not just another case.That means you should know more about me than where I went to school. I am a husband. My wife Kristi is a native New Mexican who grew up on a cattle ranch in Roy, New Mexico. Her family settled the ranch back in the early 1940s and have raised cattle and kids there ever since. I am a father. I have three wonderfully full of life children. I am also a Christian. My faith and my belief in redemption is what drives me to do this work. I don't think that you have to be a trial attorney to make the world better and to live in the likeness of Jesus, but it is what makes sense to me. If I can help people in crisis and be a calm witness in the midst of the storm, then maybe God can use that to His Glory. I am also an athlete. I love to get away from everything with a hard run in early morning hours or a solitary bike ride. I have raced the Hawaii Ironman twice and ran 100 miles at the Leadville Trail 100. I think balance in life is difficult to find, but even harder to get back aligned when out of whack. Trust me when I say, that I work as hard as anyone I know, but I will always find time for my family and for myself. In the end that time away makes me a better lawyer. As a lawyer, I have always wanted to try difficult cases to juries. To be respected by the other side, they must know that we are willing to fight all the way to the end and get results in Court. Our track record at trial speaks to who we are and how far we are willing to go to make things right. Read Full Bio   LISTEN TO PREVIOUS EPISODES & MEET THE TEAM: Great Trials Podcast Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

This week Steve and Yvonne interview Jude Basile of The Basile Law Firm (https://www.basilelaw.com/).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Guest Bio: Jude Basille Jude first began practicing law in 1982. Over the years, he has earned numerous awards as a result of his fierce dedication to protecting families and people. Jude has been named Trial Lawyer of the Year four times, and Outstanding Trial Lawyer nine times by various trial lawyer organizations. He is the only lawyer between Los Angeles and San Francisco to be part of the prestigious Inner Circle of Advocates, a national invitation-only organization that includes only the 100 top plaintiff trial lawyers in the United States. In addition, he has earned the highest rating among his peers in the legal community while enjoying the friendship and gratitude of his clients.  Nothing gives him more satisfaction, however, than finding out and overcoming injustice in the form of abuse of power and corporate greed - a mission he began in childhood. Those who know Jude best will tell you he demonstrates a depth of intensity that even those who oppose him in the courtroom cannot deny. He is simply the very best at what he does, and believes in quality over quantity when it comes to caseload, spending time with his clients in order to better understand each unique situation. Jude is an invited speaker and presenter at numerous State Bar Associations and invited to teach at various Trial Lawyer programs.  EDUCATION University of Notre Dame Edinboro University of Pennsylvania B.A. Social Science Indiana University of Pennsylvania M.S. Business Thomas Jefferson School of Law J.D. with honors BAR ADMISSIONS  US Supreme Court California 1982 Georgia 1982 (inactive) US Federal Court Read Full Bio   LISTEN TO PREVIOUS EPISODES & MEET THE TEAM: Great Trials Podcast Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

Welcome to episode 317 of The Cloud Pod, where the forecast is always cloudy! Justin, Matt, and an out-of-breath (from outrunning bears) Ryan are back in the studio to bring you another episode of everyone's favorite cloud and AI news wrap-up. This week we've got GTP-5, Oracle's newly minted AI conference, hallucinations (not the good kind), and even a Cloud Journey follow-up. Let's get into it!  Titles we almost went with this week: Oracle Intelligence: Mission Las Vegas AI World: Oracle’s Excellent Adventure AI Gets a Reality Check: Amazon’s New Math Teacher for Hallucinating Models Jules Verne’s 20,000 Lines Under the C GPT-5: The Empire Strikes Back at Computing Costs 5⃣Five Alive: OpenAI’s Latest Language Model Drops GPT-5 is Alive! (And Ready for Your API Calls) From Kanban to Kan’t-Ban: Alienate Your User Base in One Update No More Console Hopping: ECS Logs Stay Put Following the Paper Trail: ECS Logs Go Live The Pull Request Whisperer Five’s Company: DigitalOcean Joins the GPT Party WireGuard Your Kubernetes: The Mesh-iah Has Arrived EKS-tending Your Reach: When Your Nodes Need a VPN Alternative Buttercup Blooms: DARPA’s Prize-Winning AI Security Tool Goes Public From DARPA to Docker: How Buttercup Brings AI Bug-Hunting to Your Laptop Agent 007: License to Query Compliance Manager: Because Nobody Dreams of Filling Out Federal Paperwork Do Compliance Managers dream of Public Sector sheep? Blob’s Your Uncle: Finding Lost Data in the Cloud Wassette: Teaching Your AI Assistant to Go Shopping for Tools Monitor, Monitor on the Wall, Who’s the Most Secure of All? Better Late Than IPv-Never VPC Logs: Now with 100% Less Manual Labor CloudWatch Catches All the Flows in Your Organization The Organization-Wide Net: No VPC Left Behind SQS Goes Super Size: Would You Like to Quadruple That? One MiB to Rule Them All: SQS’s Payload Growth Spurt Microsoft Finally Merges with Its $7.5 Billion Side Piece From Hub to Spoke: GitHub Loses Its Independence Cloud Run Forest Run: Google’s AI Workshop Marathon From Zero to AI Hero: Google’s Production Pipeline Workshop The Fast and the Serverless: Cloud Run Drift A big thanks to this week's sponsor: We're sponsorless! Want to get your brand, company, or service in front of a very enthusiastic group of cloud news seekers? You've come to the right place! Send us an email or hit us up on our Slack channel for more info. General News  01:17 GitHub will be folded into Microsoft proper as CEO steps down – Ars Technica GitHub will lose its operational independence and be integrated into Microsoft’s CoreAI organization in 2025, ending its separate CEO structure that has existed since Microsoft’s $7.5 billion acquisition in 2018. The reorganization eliminates the CEO position, with GitHub’s leadership team reporting to multiple executives within CoreAI rather than a single leader, potentially impacting decision-making speed and product direction.

This week Steve and Yvonne interview Tom Bosworth of Bosworth Law (https://tombosworthlaw.com/).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Case Details: Attorney Tom Bosworth achieved a historic milestone by becoming the youngest lawyer in Pennsylvania to secure an eight-figure jury verdict as the lead counsel in a medical malpractice case for a living client. The case involved a medical malpractice victim who was awarded a $19.7 million verdict by a Philadelphia jury, due to a failure to diagnose. After years of seeing the same primary care physician, a woman's complaints about back pain and other symptoms were repeatedly dismissed. She sought the help of a neurologist, who discovered a mass on her spine. Unfortunately, the mass had already caused several complications, including incontinence, pain, and difficulty walking. As a result, she was left partially paralyzed and unable to continue working.   Guest Bio: Thomas Bosworth At age 33, Tom Bosworth became the youngest lawyer in the history of Pennsylvania to obtain a jury verdict in excess of $10 million for a living client as lead counsel (the total verdict being over $19 million). Three months prior to that, after two weeks as lead counsel at trial, Bosworth secured a $7 million settlement on behalf of a mother whose mentally disabled adult son wrongfully died in a group home. Bosworth also obtained multiple non-monetary terms in this settlement that were only agreed to by the defendant after two weeks of trial. In the past 5 years, Bosworth has been counsel on various additional jury trials and settlements totaling over $80 million. These cases included ones for medical malpractice, product liability, and wrongful death.   Recently, Bosworth was designated by the independent attorney group Super Lawyers as a Rising Star in Pennsylvania, a designation reserved for the top 2.5 percent of attorneys in the state who are 40 or younger or practicing 10 years or less. Bosworth attended Temple University Beasley School of Law from where he graduated in 2016 with magna cum laude and Order of the Coif distinction. During law school, Bosworth participated as a member of Temple's nationally ranked Trial Team and as a Research Editor of the Temple Law Review. Following law school, Bosworth was a law clerk to the Honorable Lawrence Stengel in the U.S. District Court for the Eastern District of Pennsylvania. Read Full Bio   LISTEN TO PREVIOUS EPISODES & MEET THE TEAM: Great Trials Podcast Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

In the aging brain, neurons begin to lose a hidden currency. Not just ATP, but GTP - that powers their ability to clear away toxic proteins. Without it, the cleanup crews stall, and amyloid builds up. A team at UC Irvine may have uncovered a way to recharge that system using two familiar compounds. In aged and Alzheimer's model neurons, this pairing restored GTP, reactivated trafficking pathways, and swept away protein aggregates. In this episode, we follow the trail from dwindling cellular energy to revived cleanup machinery, and explore how these findings fit with human evidence.00:00 Introduction: The Overlooked Clue in Aging Brains00:47 The Energy Crisis in Aging Neurons01:21 Natural Compounds to the Rescue01:55 The UC Irvine Study: A Closer Look03:05 Mechanisms Behind Nicotinamide and EGCG04:37 Human Data: What Do We Know?06:59 Comparing Strategies: Drugs vs. Natural Compounds08:11 Challenges and Future Directions09:27 Conclusion: A Promising but Unproven StrategyPMID: 40661491

This week Steve and Yvonne interview Jordan Strokovsky of Strokovsky LLC (https://actionafterinjury.com/).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Case Details: Jordan won his client a $30 million recovery against Temple University Hospital in one of the largest medical malpractice cases in Pennsylvania's history. Despite the hospital's denial of wrongdoing, Jordan refused their offer of $3 million and prepared tirelessly for court to ensure a just outcome for his client. The hospital admitted fault and the jury awarded $25.9M to Jordan's Mr. Parks ($6M for future medical costs and $20M for pain and suffering) after a comprehensive investigation and a hard-fought trial. The hospital hired three law firms in an attempt to overturn the verdict and offered a settlement less than the awarded amount. Jordan's client refused to settle, and Jordan won every argument against the big firms. The court refused the hospital's request to reduce the verdict, and $3.7 million in delay damages were added. The total recovery now exceeds $30 million, including over $600,000 in interest. No appeal was filed.   Guest Bio: Jordan Strokovsky Jordan Strokovsky is a trial lawyer serving the catastrophically injured in a diverse range of cases, including medical malpractice, birth injury, truck accidents, fires, explosions, plane crashes, premises liability, product liability, workplace injuries, toxic torts, civil rights, car accidents, and sexual assault.  His hard work ethic, integrity, and compassion earn him the trust of his clients and the respect of his opponents. These attributes have also helped him obtain significant verdicts and settlements. For good reason, many lawyers refer or seek to co-counsel their serious injury and wrongful death cases with Jordan. Jordan handles countless catastrophic injury and wrongful death cases and routinely handles cases pro bono to help his community. His volunteer work includes taking a civil rights case to verdict with the Volunteer Attorney Panel of the Eastern District of Pennsylvania, representing victims of sexual abuse with the Support Center for Child Advocates, and successfully handling various cases from Philadelphia VIP. He has been recognized by the court for his service and was a featured volunteer by Philadelphia VIP. As an animal lover and dog owner, Jordan has also championed animal rights causes, helping establish that pets should not be viewed as property under the law. He also serves on the Pennsylvania Association for Justice Board of Directors and has previously served on boards for non-profits that help animals, homeless people, and refugees. Jordan is the former co-chair of the State Civil Litigation Section of the Philadelphia Bar Association and was proud to help implement town halls at the start of the pandemic, which allowed the court and legal community to communicate during those uncertain times. He now co-chairs both the Civil Rules and Wellness Committees at the bar association. Jordan has served as an adjunct law school professor and occasionally speaks at seminars to other personal injury lawyers.  He is also regularly asked by news outlets to provide legal commentary. Jordan graduated from Widener University Delaware Law School as Valedictorian of his class, where several of his professors would comment that his academic performance and mind for the law were among the most impressive they had ever seen. While in school, he interned with three Philadelphia judges: the Honorable M. Faith Angell (E.D. Pa), the Honorable Arnold L. New (Common Pleas), and the Honorable Paul P. Panepinto (Common Pleas) and used these internships as opportunities to get in the courtroom and watch many trials. He was also a member of the Law Review. After his commencement speech at graduation, the Governor of Delaware declared that he would never want to follow Jordan in speaking again. While practicing law full-time, Jordan obtained a Master of Law in Trial Advocacy at the nationally renowned Temple University Beasley School of Law LL.M. Program in the Spring of 2018, where he received special recognition from the faculty for his trial performances and was a jury favorite—earning the highest scores from the jury at his showcase trial. Read Full Bio   Show Sponsors: Legal Technology Services - LegalTechService.com Harris Lowry Manton LLP - hlmlawfirm.com   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

A week of track choices and track comfort; AO Racing to GTP; new cars.

In this episode of the Great Trials Podcast, hosts Steve Lowry and Yvonne Godfrey interview Tom D'Amore from the D'Amore Law Group about the significant case of Nelson vs. TMT Development Company and Cornerstone Security Group Remember to rate and review GTP on Apple Podcasts, Spotify or your favorite platform. --- Case Details: An Oregon state court jury awarded $21.25 million, including $1.25 million in punitive damages, to the family of a man killed by a private security guard during an altercation in a Lowe's parking lot. The Multnomah County jury found property manager TMT Development Corp, property owner Hayden Meadows and three representatives of Cornerstone Security Group liable for the 2021 death of Freddy Nelson Jr. Former Cornerstone security guard Logan Gimbel, currently serving a life sentence after a second degree murder conviction over the incident, shot Nelson through the windshield of his pickup truck after ordering Nelson to leave the Lowe's lot, where he claimed he had an arrangement with a store employee to pick up and remove excess wooden palates. (SOURCE) --- Guest Bio: Tom D'Amore Tom D'Amore is a trial lawyer dedicated to preserving the civil justice system. Tom has earned a reputation among insurance companies, corporations, and opposing counsel as a skilled, experienced, aggressive, and ethical personal injury attorney. Tom is an experienced and board-certified civil trial attorney with the National Board of Trial Advocacy. Tom was selected by Super Lawyers and his peers as one of the Top 50 lawyers in Oregon. Tom and D'Amore Law Group are AV Preeminent rated for the highest ethical standards and professional ability by Martindale-Hubbell. In 2016, Tom was awarded the Arthur H. Bryant Public Justice Award by the Oregon Trial Lawyers Association (OTLA). An attorney for more than 30 years — and a former CPA with a Big 8 accounting firm —Tom is licensed to practice law in Oregon, Washington, and California. He founded D'Amore Law Group in 1994 with the mission of securing justice for injured people, victims of wrongful death, and their families. Tom is actively engaged in the plaintiff's trial bar. Tom is a national Board of Governor, past Executive Committee member, and past Budget and Audit Chair of the American Association for Justice (AAJ) in Washington, D.C. Tom is Past President of the Oregon Trial Lawyers Association and an Eagle member of the Washington State Association for Justice (WSAJ). (READ FULL BIO) --- LINKS FROM THE EPISODE:

Ready to move beyond glycolysis? In Episode 26 of the Jack Westin MCAT Podcast, Mike and Molly guide you through the Pyruvate Dehydrogenase Complex (PDC) and the Citric Acid (TCA) Cycle—two of the highest‑yield pathways the MCAT loves to test.What we cover- Where it all happens – cytoplasm vs. mitochondrial matrix- PDC outputs & regulation – 2 Acetyl‑CoA, 2 NADH, 2 CO₂ and the key activators/inhibitors that flip the complex on or off- Real‑world connections – how arsenic poisoning and Wernicke‑Korsakoff syndrome derail PDC function- TCA Cycle essentials – step‑by‑step walk‑through, enzyme mnemonics (“Can I Keep Selling Shells…”) and the must‑know Big 3 regulators- High‑yield nuggets – why Succinate Dehydrogenase pulls double duty as ETC Complex II, Ca²⁺ activation during muscle contraction, plus glucogenic vs. ketogenic amino acid entry pointsBy the end, you'll know the exact products (NADH, FADH₂, GTP, CO₂), how to spot test‑maker tricks, and which regulatory enzymes to memorize for test day.

In this episode of the Great Trials Podcast, Steve Lowry converses with Brian McKeen from McKeen and Associates about a significant medical malpractice case, Drake versus Henry Ford Health System. Remember to rate and review GTP on Apple Podcasts, Spotify or your favorite platform. --- Case Details: "DETROIT – March 29, 2024– McKeen & Associates attorneys Brian McKeen and John LaParl, along with a Michigan Health and Human Service attorney, won a jury verdict in Wayne County Circuit Court yesterday for $120 million on behalf of a boy who suffered a birth injury at Henry Ford Health System. The jury found Henry Ford Health System and the attending obstetrician and nurses were negligent in failing to perform a timely Caesarian section resulting in severe birth injuries. The baby's mother arrived at Henry Ford Hospital in June 2010. She was at term, but not near delivery. Sometime after admission, the fetal monitor indicated “non-reassuring fetal heart tones” and a Caesarean section was called for. Because the procedure was delayed more than two hours, the infant suffered from severe asphyxiation resulting in cerebral palsy and permanent brain damage. The boy will require lifelong care. The Michigan Department of Health and Human Services joined the case against the defendants due to the exorbitant cost they have incurred for the medical care for the child, who is now 13 years old." (SOURCE) --- Guest Bio: Brian McKeen Brian McKeen began practicing law in 1982. During his career, he has become a powerful advocate for his clients and one of the foremost medical malpractice attorneys in Michigan. He has tried cases throughout the United States. He currently sits on the executive boards of the Michigan Association for Justice (MAJ) and the American Association for Justice (AAJ). Mr. McKeen formerly served as chair of the AAJ Professional Negligence Section, Medical Negligence Exchange Group and Birth Trauma Litigation Group (BTLG). Since 2001, McKeen & Associates has generated the year's top verdict in Michigan four times, including securing the state's largest medical malpractice verdict on record in 2001, when a jury rendered a verdict award of $55 million in the case of Hall v Henry Ford Health System. McKeen & Associates also topped all Michigan verdict awards in 2002, with an award of $22.5 million in the case of Blazo v McLaren Regional Medical Center, et al; in 2006 with an award of $16 million in the case of Lowe v Henry Ford Health System; and in 2007, with an award of $35 million in the case of Oppenheim v Aeneas C. Guiney. Mr. McKeen was recently inducted to The Inner Circle of Advocates and named Top Attorneys in Michigan as published by The New York Times in September 2012. (READ FULL BIO) --- LINKS FROM THE EPISODE: McKeen and Associates ONLINE McKeen and Associates LINKEDIN McKeen and Associates FACEBOOK --- LISTEN TO PREVIOUS EPISODES & MEET THE TEAM: Great Trials Podcast Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production

This week, Steve and Yvonne interviewed Matt Cook of Cook Law Group LLC (www.cook-lawgroup.com) and Shane Lazenby of Lazenby Law Group (lazlawgroup.com).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Case Details: On April 23, 2016, a fatal crash resulted in the loss of Taliah Freeman, a 32-year-old resident of Gainesville, GA, who lost her life in a devastating collision along Interstate 85 in Gwinnett County. Sandra Gallo, Freeman's mother, brought the case on behalf of her six-year-old son. The defendants in the case were C&T Durham Trucking Company of Greensboro, North Carolina, and ACE American Insurance Company. The case ended nearly eight years later, with a settlement totaling $10 million between the parties, with approximately 95% of the settlement amount going to Freeman's family. Source    Guest Bios: Matt Cook Matt grew up in Northeast Georgia, the son of a single mom. While he and his mother had very little worldly means, they had grit, determination and a commitment to decency and fairness. Matt's upbringing gave him a healthy respect for hard work and for standing up for the underdog. Matt spent three years working in cotton mills and other manual labor jobs before graduating college and attending law school. After graduating law school, Matt joined a nationally renowned trial lawyer firm where he spent six years as an associate and five years as a partner handling a broad range of complex, catastrophic injury and death cases across the United States ranging from trucking collisions to product liability claims and everything in between. Matt is a frequent speaker at trial lawyer seminars, has published numerous articles, and has served as an expert witness in several cases. Matt is an aviation enthusiast and has his private pilot's license. Matt's unique style, genuine empathy, ability to relate to juries, and fearlessness have led to hundreds of millions of dollars of recoveries for clients. Matt has secured more than $225 million for clients in just the past 10 years. Read Full Bio   Shane Lazenby Shane Lazenby is the founder and managing member of Lazenby Law Group. After more than a decade of defending those accused of negligence in personal injury cases, Shane decided to reverse course and help the victims of serious injuries. With unparalleled compassion and limitless commitment, Shane quickly learned how much more rewarding and uplifting service as a victim's advocate can be. Shane now focuses his practice on helping the victims of catastrophic personal injury and the families whose loved ones have passed as a result of the negligence of another. Read Full Bio   Show Sponsors: Legal Technology Services - LegalTechService.com Harris Lowry Manton LLP - hlmlawfirm.com   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2   Podcast Production Team: Dee Daniels Media

This week Steve and Yvonne interview Daniel Callahan, founding partner of Callahan & Blaine (https://www.callahan-law.com/)  and owner of Callahan Consulting (https://callahanconsulting.com/).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Guest Bio: Daniel Callahan Throughout his career, Daniel J. Callahan has always been known as one of the top trial attorneys in California.  His notable jury verdicts included a $934,000,000 jury verdict obtained after a three-month jury trial in a complex business dispute entitled Beckman Coulter vs. Flextronics. This unanimous verdict was the largest in California in 2003 and remains the largest in Orange County history. Mr. Callahan also went on to obtain a $50,000,000 settlement in a road design case against the City of Dana Point. Exclusive of large class actions, this continues to be the largest personal injury settlement in United States history. Mr. Callahan also obtained, after a two-month jury trial, a $38 Million settlement on behalf of a class of newspaper delivery drivers against The Orange County Register. This is still the highest employment settlement in Orange County's history. Mr. Callahan grew up in Chicago, Illinois where he went on to receive his BA, magna cum laude, from Western Illinois University in 1976, and graduated with honors from the UC Davis School of Law in 1979, while serving as Editor of the Law Review. He began his career in Hawaii before relocating to Southern California and starting his own firm by opening the doors on St. Patrick's Day, 1984. Mr. Callahan also provides corporate consulting to law firms and lawyers regarding litigation and strategy through Callahan Consulting Group, LLC. Read Full Bio Here   Show Sponsors: Legal Technology Services - LegalTechService.com Digital Law Marketing - DigitalLawMarketing.com Harris Lowry Manton LLP - hlmlawfirm.com   Free Resources: Stages Of A Jury Trial - Part 1 Stages Of A Jury Trial - Part 2

GTP CLASSIC EPISODE: This week Steve and Yvonne interview T. Gabe Houston of The Trial Lab (https://thetriallab.com/).   Remember to rate and review GTP in iTunes: Click Here to Rate and Review   View/Download Trial Documents   Case Details: In June 2013, Thomas Joseph (“Joey”) Soulliere was riding his recently-purchased motorcycle down a public road. Suddenly, a driver in an SUV pulled out of a parking lot directly in front of him. While the situation was dire, Joey certainly had sufficient time to brake so as to avoid the SUV. Unfortunately, Joey's bike, a 2009 Suzuki GSXR 600, contained a defect within its Front Brake Master Cylinder (a defect which had been known for years by its designer and manufacturer, Suzuki Motor Corporation) which resulted in sudden and complete front brake failure. Having no front brake, Joey violently crashed into the SUV. His injuries included fracture of his right femur, right patella, and left foot. The patella injury was severe, requiring multiple surgeries (including for burst ligaments and infection). Joey also developed orthopedic injuries in his right shoulder and lower back, and continued to have chronic pain in his legs for years. (Source) Guest Bio: Gabe Houston Gabe Houston is the founding member of The Trial Lab Corporation (Formerly Houston Law of California, PC), a law firm devoted to enthusiastically representing aviation-related disputes as well as compassionately helping injured people. In personal injury matters, our job is to help injured people realize their brighter futures. The Trial Lab helps innocent injured victims who have been hurt due to the carelessness of others. Our clients have suffered a catastrophic personal injury, typically by defective products, dangerous properties, or other negligent people, or have been injured on an airline or by a doctor or hospital. The Trial Lab also represents clients in cases involving Qui Tam/Whistleblower matters. T. Gabe Houston has complex trial, arbitration, mediation, and negotiation experience. The Trial Lab and its trial attorneys have successfully tried and arbitrated multiple complex cases to verdicts in the areas of aviation litigation, product liability actions, personal injury, medical malpractice, and as well as defending wrongly charged or accused criminal defendants. The Trial Lab has also represented pilots against regulatory agencies such as the FAA and NTSB as well as representing clients in securities and commodities regulatory and administrative litigation. Gabe Houston and Caroline Blanco originally founded the law firm Houston and Blanco in 2008. Gabe and Caroline married, and Caroline left the practice of law to be the bedrock of a growing household. Gabe continued the practice as Houston Law of California. In 2012 Gabe suspended the solo practice when he was recruited to join a prominent medical malpractice firm where he used his trial knowledge and litigation experience to represent innocent victims of medical malpractice in suits against negligent physicians and health care providers. In 2018, Gabe returned to solo practice to stay focused on helping injured victims of catastrophic personal injury, defective products, dangerous premises, and airline injuries. Gabe is a long-time member of the Consumer Attorneys of California (CAOC) and the Orange County Trial Lawyers Association (OCTLA). Gabe was a long-time member of the Board of Directors of OCTLA and was on the Executive Committee, where he served as Parliamentarian through First Vice President before pivoting to bi-coastal trial practice. Read Full Bio Check out previous episodes and meet the GTP Team: Great Trials Podcast --- Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production

In this episode of the Great Trials Podcast, hosts Steve Lowry and Yvonne Godfrey discuss the case of Ramirez v. Avalon Mobile Home Park with guests Tony DelCampo, Randy Grayson, and Dax Lopez from DGL Attorneys At Law. Remember to rate and review GTP on Apple Podcasts, Spotify or your favorite platform. --- Case Details: "After a one-week trial, a jury returned a verdict of $31 million for the wrongful death of Israel Ramirez. Mr. Ramirez was living with his sister and brother-in-law at Avalon Mobile Home Park. Avalon had experienced multiple crimes in the years before Israel's death. While home from work for lunch, Israel and his sister saw a thief stealing his car from his home. Israel reacted quickly and confronted the thief, who shot and killed him. Avalon failed to have reasonable security in place to protect its residents from foreseeable crimes. At trial, Avalon tried to blame Israel for his own death, claiming he should not have reacted to the theft of his vehicle. The defense claimed Israel acted unreasonably for defending his property. Our firm introduced evidence that the husband of Avalon's property manager had left his own home to confront trespassers with a loaded gun on a previous occasion, contrasting the defense's blaming Israel while celebrating a different resident who survived a similar encounter. After hearing from Israel's family members, including his children, the jury determined the value of his lost life, pain and suffering and awarded $31 million against Avalon Mobile Home Park." (Source)  --- Guest Bio: Tony DelCampo J. Antonio DelCampo, an esteemed attorney and former State Court Judge in DeKalb County, brings a wealth of experience and a track record of success to his practice. Known for his adept handling of complex cases, Tony has presided over high-profile matters, including civil claims stemming from the Brian Nichols courthouse shooting case, intricate medical malpractice suits, and product liability trials with significant verdicts, including one of the largest in the state's history. Read Full Bio Guest Bio: Randall D. Grayson Randall Grayson is an experienced litigator and trial lawyer. He is a founding member of the firm and has been with DGL since 2013. He began his practice in Georgia at Alston & Bird, one of the largest law firms in the country. Over the years, he has represented individuals, businesses, executives, and workers in a wide variety of cases and has tried several different lawsuits to successful jury verdicts. Read Full Bio Guest Bio: Dax López For nearly 11 years, Dax served as a judge on the State Court of DeKalb County where he presided over hundreds of jury trials in complex criminal and civil matters. As only the second Hispanic judge on a court of record in the history of Georgia, Dax was known to be an efficient, fair, and just jurist who earned the respect of lawyers and litigants alike. Now as a trial lawyer, Dax uses his perspective as a former judge to fight for his clients, many of whom have been injured because of the negligence of others. Dax has been able to utilize the skills he learned while serving as a judge to obtain significant verdicts in the courtroom. Read Full Bio --- LINKS FROM THE EPISODE: DGL Attorneys on Facebook DGL Attorneys on Instagram DGL Attorneys Website --- Check out previous episodes and meet the GTP Team: Great Trials Podcast --- Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production

In this episode of the Great Trials Podcast, hosts Steve Lowry and Yvonne Godfrey are joined by renowned Miami lawyer Sagi Shaked. They delve into a significant wrongful death case Shaked successfully tried in 2017, resulting in a $12,240,000 verdict. Remember to rate and review GTP on Apple Podcasts, Spotify or your favorite platform. --- Case Details: "After a 4-day trial, we obtained a $12,240,000.00 verdict on behalf of a family that lost their mother as a result of a tragic head-on automobile collision. The trial team consisted of Sagi Shaked, Joel Roth, Manny Lorenzana and Iury Carvalho. Unfortunately, Roitiki Tyler only got to see her star athlete son play one college game. Tyler was accompanied by her 11-year-old, who flew from Florida to Iowa to watch Devontre Tyler play middle linebacker in a Saturday game in November 2014. The following night, Tyler was driving home when a Ford F-150 truck hit them head-on at 65 mph. The mother of two died. Her young son survived his mother without physical injuries, but whose subsequent emotional traumatization led a jury to award them with $12.24 million." (Source) (More Coverage on Case Details) --- Guest Bio: Sagi Shaked As an experienced Miami personal injury lawyer, Sagi Shaked actively litigates cases involving catastrophic injuries and wrongful death on behalf of victims and their families. These cases include car accidents, product liability, medical negligence and malpractice, nursing home abuse and neglect, trucking accidents, industrial manufacturers, insurance disputes, premises liability, drowning accidents, airline accidents, burn-related accidents, and others. Sagi Shaked has been practicing law since 2000 and went on to found the successful Shaked Law Personal Injury Lawyers in 2007, where he became one of the Top 100 Trial Lawyers in the United States as named by the American Trial Lawyers Association. This highly coveted honor was bestowed upon Mr. Shaked for his exemplary legal expertise, compassion for his clients, and consistently recovering multi-millions of dollars in damages for those he represents.  Read Full Bio --- LINKS FROM THE EPISODE: Shaked Law Firm on Facebook Sagi Shaked on LinkedIn Shaked Law Firm on Instagram Shaked Law Firm on YOUTUBE --- Check out previous episodes and meet the GTP Team: Great Trials Podcast --- Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production

Have you ever experienced GTP or Game Transfer Phenomenon? A condition where the physical world and video games bleed together. What new research discovered about the stylistic differences between news articles written by human journalists and those generated by AI. And Apple airlifts U.S. around 1.5 million iPhones to avoid tariffs on Chinese imports. And DoorDash starts robot deliveries in Los Angeles and Chicago. Starring Sarah Lane, Robb Dunewood, Roger Chang, Joe. To read the show notes in a separate page click here! Support the show on Patreon by becoming a supporter!

In this episode of The Great Trials Podcast, hosts Steve Lowry and Yvonne Godfrey discuss the case of Robert and Virginia Rymers vs. CPS Energy with trial lawyers Mike Lyons and Chris Simmons of Lyons & Simmons. Remember to rate and review GTP on Apple Podcasts, Spotify or your favorite platform. --- Case Details: The case involves a devastating natural gas explosion in a San Antonio home that resulted in severe burn injuries to Robert and Virginia Rymers. The gas lines had not been properly maintained or inspected by CPS Energy. The defense argued it was not a natural gas explosion, positing alternative theories. However, the jury sided with the plaintiffs, resulting in a $109.5 million verdict. (Source) --- Guest Bios: Michael Lyons Michael Lyons is one of the founding partners of Lyons & Simmons and concentrates his practice on representing plaintiffs in catastrophic personal injury and wrongful death cases as well as “bet the company” complex business disputes. Lyons has a national reputation for achieving outstanding results for his clients by displaying a mastery of the facts and law while utilizing creativity, tenacity, and cutting-edge technology. Over the past 25+ years of practice, Lyons has tried cases to juries, judges, and arbitrators throughout the state of Texas and all over the country. In the process, Lyons has obtained verdicts, awards, and settlements totaling over a billion dollars on behalf of his clients—many involving high profile, high exposure matters. Lyons has extensive trial experience in cases involving catastrophic personal injuries, wrongful death, and product liability. Lyons' cases are as diverse and extensive as his approach to his cases. He has handled cases involving: brain and spinal cord injuries, electrocutions, aviation disasters involving helicopters and airplanes, trucking accidents, construction site accidents, industrial accidents, motor vehicle products liability, pharmaceutical, and medical device products liability, large business disputes involving breach of contract, fraud, and breach of fiduciary duties, medical malpractice, high profile contract disputes involving college football coaches and celebrities, and fire and explosion cases. Read Full Bio --- Guest Bios: Christopher Simmons Chris Simmons is one of the founding partners of Lyons & Simmons. He focuses his practice on representing plaintiffs in catastrophic personal injury and wrongful death cases. He has developed a reputation as a highly-skilled warrior who combines a tireless work ethic with a creative and innovative approach to achieve results for the people that matter most—his clients. Simmons treats his clients' problems as his own. Simmons wants his clients to know that he will stand up for them against their opponents. Anytime. Anywhere. Simmons is a firm believer that results speak louder than words and with that mindset he pursues justice for his clients. His pursuit of justice has resulted in him trying cases to verdict throughout the state of Texas and obtaining multimillion-dollar results for his clients in states across the country. Simmons, along with firm Co-Founder Michael Lyons, has assembled a team of lawyers that has been consistently recognized as leaders in their field. Simmons and his team have recovered hundreds of millions of dollars in judgments, awards, and settlements on behalf of their clients. Read Full Bio --- LINKS FROM THE EPISODE: Lyons & Simmons on Facebook Lyons & Simmons on LinkedIn Lyons & Simmons on Instagram --- Check out previous episodes and meet the GTP Team: Great Trials Podcast --- Show Sponsors: Legal Technology Services  Harris Lowry Manton LLP - hlmlawfirm.com Production Team: Dee Daniels Media Podcast Production

It's The Week In Sports Cars show featuring Marshall Pruett and DailySportsCar.com's Graham Goodwin. TOPICS: Ford chooses its GTP chassis supplier, Aston Martin reveals liveries and drivers, a silly bird-themed plan for Sebring, and more! Every episode is graciously supported by the Justice Brothers, the Sports Car Championship Canada, and TorontoMotorsports.com.  NEW show stickers and memorabilia: ThePruettStore.com If you'd like to join the PrueDay podcast listener group, send an email to pruedayrocks@gmail.com and you'll be invited to participate in the Discord chat that takes place every day and meet up with your new family at events. Play on Podbean.com: https://marshallpruett.podbean.com/ Subscribe: https://marshallpruettpodcast.com/subscribe Join our Facebook Group: https://www.facebook.com/MarshallPruettPodcast [WSC]