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2 episodes with braca
2 episodes with braca
2 episodes with braca
4 episodes with braca
Epizod 23 sezon 5 Rashford vs Coach li City preske deyo lan LDC Vini pral travay pou Mbappe Real vs Braca ou Liverpool lan LDC Neymar tounen lakay li
Dargo and Braca get unexpectedly close when Rygel and Scorpius's negotiations are interrupted by a plot from Pulp Fiction. Meanwhile Moya and the crew have a heartbreaking decision to make. This episode's guest:Ren Krueger (she/they)Creator: Rent the BarbarianYoutubehttps://www.youtube.com/c/RenTheBarbarian/featuredhttps://twitter.com/renthebarbarianhttps://www.instagram.com/renthebarbarian/https://www.tumblr.com/victorian-sexstachePodcast socialshttps://www.youtube.com/channel/UCz-9cHDhut44XA-hQ-RMw6Qhttps://www.patreon.com/muppetssexandtraumahttps://muppetsexandtrauma@gmail.comhttps://twitter.com/muppetssexandt1https://www.facebook.com/Muppets-Sex-and-Trauma-a-Farscape-Podcast-114029207450715Discord:https://discord.com/invite/CqnhYFVRzXOur vital info:Sara Ezzat (she /her)Creator: The Fat Culture Critichttps://www.youtube.com/c/TheCostumeCodexhttps://twitter.com/bluestockinsarahttps://www.instagram.com/sara_fat_culture_critic/Josh Gosdin (he/him)Nerd and lover of all things Star Trekhttps://www.instagram.com/joshgosdin/
CATHARINE JANSSEN is the owner of Braca-shirts, is a cancer coach, cancer awareness educator, public speaker, and author and whose clients are corporations who need guest speakers or workshops - cancer organizations - cancer patients and Catharine provides essential knowledge to individuals facing cancer, equipping them with a foundation for understanding physiology, their microbiome, healthy food choices, and the psychology of cancer.Here's where to find more:https://www.bracashirts.cawww.facebook.com/bracashirts ___________________________________________________________Welcome to The Unforget Yourself Show where we use the power of woo and the proof of science to help you identify your blind spots, and get over your own bullshit so that you can do the fucking thing you ACTUALLY want to do!We're Mark and Katie, the founders of Unforget Yourself and the creators of the Unforget Yourself System and on this podcast, we're here to share REAL conversations about what goes on inside the heart and minds of those brave and crazy enough to start their own business. From the accidental entrepreneur to the laser-focused CEO, we find out how they got to where they are today, not by hearing the go-to story of their success, but talking about how we all have our own BS to deal with and it's through facing ourselves that we find a way to do the fucking thing.Along the way, we hope to show you that YOU are the most important asset in your business (and your life - duh!). Being a business owner is tough! With vulnerability and humor, we get to the real story behind their success and show you that you're not alone._____________________Find all our links to all the things like the socials, how to work with us and how to apply to be on the podcast here: https://linktr.ee/unforgetyourself
“I'm going to heaven—who's coming with me?” Charolette Tallent tells the story of Al Braca, who died in the World Trade Center attacks September 11, 2001. Al lived his Christian life intentionally and with purpose and was able to lead many to the Lord during the events of that tragic day. #NAFWB #BetterTogether #September11 #WorldTradeCenter
Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions: Charlye: Hi Dr. Cabral, I am a 28 yr old female, I'm fit with a muscular body type. I recently had my first baby, she was delivered via c-section at 33 weeks due to fetal distress. 5 days postpartum I was re-admitted to the hospital for high blood pressure with low heart rate. I have always had great blood pressure and I tested negative for preeclampsia. After EKGs and an Ecmo, It was determined I had bradycardia and a Wenckebach block, due to high vagal tone. I've always had a low resting heart, rate 50-60s awake, 40s while sleeping. I also struggle with intense general anxiety and had a stressful pregnancy. I'm curious about the biophysical relationship between the vagal nerve, my bradyarrhythmia, my anxiety, and my pre-term birth and how to approach healing and balancing my body. Thanks! Kathryn: I am currently breastfeeding my toddler and I just haven't been able to quit vaping. I stopped while I was pregnant but picked up the habit again due to stress about 7 months postpartum. I have stopped for a few weeks here and there but my partner vapes and I always end up vaping again. The nicotine level is the lowest you can get. I'm mostly worried about the heavy metals getting into my breast milk. Is it best to stop breastfeeding if I can't quit vaping? How much harm am I doing to my child? I wish I had more support from my partner to quit but he assures me it's harmless. I feel like the worst mother ever. Stacey: Hi Dr.Cabral I just want to say thank you for taking so much time to answer questions and be here for us all ! I just found out my mother has breast cancer . My grandmother and aunt had it as well . We don't know the stage as of yet . What do you suggest we do for now to help her body get strong enough to fight this . I'm terrified and can't think of it without crying as I have health issues myself and trying so hard to just keep my head above water for my kids . My mom is my grandmas care taker and it's just a very scary situation. Also do you suggest BRACA testing for me and possibly removal of my tissue ? I need to have a breast explant so I'm thinking do it then . So much to consider in all of this . Thanks so much for your guidance. Melissa: Question about not sweating during workouts. I am hydrated, I do LMNT water 30 minutes prior and 32 ounces water during. All I drink is water and always has electrolytes in it I just don't sweat easy. I heard on the latest genius life podcast (episode 364 at the 56ish minute mark) that sometimes you can have a cell that holds on and will not release so I'm wondering if you've heard of that and if there's a way to detox so that I can't start sweating easily? I can't sweat if I get an asana or workoutside in the heat. Just not during workouts. And I want to detox. Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions! - - - Show Notes and Resources: StephenCabral.com/2962 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
Episode 23 is the birth story of Nia, who Tash gave birth to at home after having had a c-section. Tash tells her experience of a 'failed' induction for an unclear and inconsistent pre eclampsia diagnosis, that also led to the seperation of her and baby Leo, and ultimately severly impacted her post partum. Tash wasn't aware of homebirth, until choosing continuity of care, and learning from her private midwife of the possibility of homebirth. This is a powerful and beautiful story of Tash getting bacl her self belief as a woman, and as a mum. Links to people/business/resources for this episode:Breast Cancer & the Braca 1 Gene https://www.breastcancerspecialist.com.au/procedures-treatment/prophylactic-mastectomy-risk-reducing-mastectomy-immediate-reconstructionBMI and pregnancy https://www.sarawickham.com/plus-size-pregnancy/Double Uterus https://www.mayoclinic.org/diseases-conditions/double-uterus/symptoms-causes/syc-20352261Hypertension in pregnancy https://australianprescriber.tg.org.au/articles/management-of-hypertension-in-pregnancy.htmlWhy Induction Matters by Dr Rachel Reed https://www.rachelreed.website/wimHBAC research https://www.sarawickham.com/research-updates/hbac/The Positive Birth Company https://thepositivebirthcompany.co.uk/FREE Antental Classes https://coreandfloor.com.au/products/antenatal-classesVaginal Examinations on The Great Birth Rebellion Podcast https://www.melaniethemidwife.com/podcasts/the-great-birth-rebellion/episodes/2147802824Support the show
On this week's Serbian Corner, Miroslav is joined by one of Serbia's first NBA play-by-play commentators, and a journalist living in Washington DC that interviewed NBA players from former Yugoslavia many times Braca Đorđević, to talk about how much it meant to Nikola Jokić that Aaron Gordon's traveled to Sombor, Serbia, to hang out while there's zero basketball activities. Other topics include: - Calling NBA games in the middle of the Night in Serbia - European players that helped the NBA become a global league - Vlade Divac, a Jokić before Jokić - Nikola choosing rest over playing for the National Team - Can FIBA tournaments become more attractive to the best players? - Michael Malone as a volleyball fan - Serbian admiration of great basketball coaches - Why was Nikola Jokić such an enigma for the National Media for so long? - Nikola's growth over the years An ALLCITY Network Production PARTY WITH US: http://bit.ly/3D9aqH1 ALL THINGS DNVR: https://linktr.ee/dnvrsports SUBSCRIBE: / dnvr_sports BUY GOLDEN ERA: https://www.triumphbooks.com/golden-e... This episode is brought to you by BetterHelp. Give online therapy a try at https://betterhelp.com/DNVR and get on your way to being your best self. Visit https://www.breckenridgedistillery.co... for your chance to win Breckenridge Distillery prizes AND Broncos tickets!! Head to https://factormeals.com/dnvrnugs50 and use code dnvrnugs50 to get 50% off. Download the Gametime app, create an account, and use code DNVR for $20 off your first purchase. Check out https://pinsandaces.com and use code DNVR to receive 15% off your first order and get free shipping. Use Code: DNVR for 50% off 2 or more pairs of polarized sunglasses at https://ShadyRays.com Check out FOCO merch and collectibles here https://foco.vegb.net/DNVRNugs and use promo code “DNVR” for 10% off your order on all non Pre Order items. AG1 is going to give you a FREE 1 year supply of immune-supporting Vitamin D AND 5 FREE travel packs with your first purchase. Just visit https://drinkAG1.com/NUGGETS Go to https://saturdayneon.com and use code DNVR for 10% off your order today. When you shop through links in the description, we may earn affiliate commissions. Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. bet365: Go to https://www.bet365.com/olp/open-accou... or use code DNVR365 when you sign up! Must be 21+ and physically located in CO. Please gamble responsibly. If you or someone you know has a gambling problem and wants help call or TEXT 1-800-GAMBLER Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of ASCO Educational podcasts, we'll explore how we interpret and integrate recently reported clinical research into practice. Part One involved a 72-year old man with high-risk, localized prostate cancer progressing to hormone-sensitive metastatic disease. Today's scenario focuses on de novo metastatic prostate cancer. Our guests are Dr. Kriti Mittal (UMass Chan Medical School) and Dr. Jorge Garcia (Case Western Reserve University School of Medicine). Together they present the patient scenario (1:13), going beyond the one-size-fits-all approach (4:54), and thinking about the patient as a whole (13:39). Speaker Disclosures Dr. Kriti Mittal: Honoraria – IntrinsiQ; Targeted Oncology; Medpage; Aptitude Health; Cardinal Health Consulting or Advisory Role – Bayer; Aveo; Dendreon; Myovant; Fletcher; Curio Science; AVEO; Janssen; Dedham Group Research Funding - Pfizer Dr. Jorge Garcia: Honoraria - MJH Associates: Aptitude Health; Janssen Consulting or Advisor – Eisai; Targeted Oncology Research Funding – Merck; Pfizer; Orion Pharma GmbH; Janssen Oncology; Genentech/Roche; Lilly Other Relationship - FDA Resources ASCO Article: Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019 ASCO Course: How Do I Integrate Metastasis-directed Therapy in Patients with Oligometastatic Prostate Cancer? (Free to Full and Allied ASCO Members) If you liked this episode, please follow the show. To explore other educational content, including courses, visit education.asco.org. Contact us at education@asco.org. TRANSCRIPT Disclosures for this podcast are listed on the podcast page. Dr. Kriti Mittal: Hello and welcome to this episode of the ASCO Education Podcast. Today, we'll explore how we interpret and integrate recently reported clinical research into practice. In a previous episode, we explored the clinical scenario of localized prostate cancer progressing to metastatic hormone-sensitive disease. Today, our focus will be on de novo metastatic prostate cancer. My name is Kriti Mittal and I am the Medical Director of GU Oncology at the University of Massachusetts. I am delighted to co-host today's discussion with my colleague, Dr. Jorge Garcia. Dr. Garcia is a Professor of Medicine and Urology at Case Western Reserve University School of Medicine. He is also the George and Edith Richmond Distinguished Scientist Chair and the current Chair of the Solid Tumor Oncology Division at University Hospitals Seidman Cancer Center. Here are the details of the patient case we will be exploring: The patient also notes intermittent difficulty in emptying his bladder with poor stream for the last six months. A CT scan of the abdomen and pelvis demonstrates enlarged prostate gland with bladder distension, pathologically enlarged internal and external iliac lymph nodes, and multiple osteolytic lesions in the lumbar sacral, spine, and pelvic bones. A CT chest also reveals supraclavicular lymphadenopathy and sclerotic foci in three ribs. So this patient meets the criteria for high-volume disease and also has axial and appendicular lesions. The patient was admitted for further evaluation. A bone scan confirmed uptake in multiple areas identified on the CT, and a PSA was found to be greater than 1500. Biopsy of a pelvic lymph node confirmed the diagnosis of prostate cancer. This patient is somewhat different from the first case we presented in terms of timing of presentation; this patient presents with de novo metastatic high-volume disease, in contrast to the first patient who then became metastatic after undergoing treatment for high-risk localized disease. Would you consider these two cases different for the purposes of dosing docetaxel therapy when you offer upfront triplet therapy combinations? Dr. Jorge Garcia: That's a great question. I actually do not. The natural history of someone with localized disease receiving local definitive therapy progressing over time is different than someone walking in with de novo metastatic disease. But now, with the challenges that we have seen with prostate cancer screening, maybe even COVID, to be honest with you, in North America, with the late care and access to testing, we do see quite a bit of patients actually walking in the office with de novo metastatic disease. So, to me, what defines the need for this patient to get chemotherapy is the volume of his disease, the symptoms of his disease – to be honest with you – and the fact that, number one, he is clinically impaired. He has symptomatic disease, and he does have a fair amount of disease, even though he may not have visceral metastasis. Then his diseases give him significant pain. Oral agents are very good for pain control. I'm not disputing the fact that that is something that actually these agents can do. But I also believe I'm senior enough and old enough to remember that chemotherapy, when it works, can actually really alleviate pain quite drastically. So for me, I think that the way that I would probably counsel this patient is to say, "Listen, we can give you ADT plus an oral agent, but I really believe your symptomatic progression really talks about the importance of rapid control of your disease.” And based upon the charted data from the United States, and equally important, PEACE-1, which is the French version of ADT, followed by abiraterone, if you will, and certainly ARASENS is the standard of care for me for a patient like this will be triple therapy with ADT and docetaxel. What I think is important for us to remember is that, in ARASENS, it was triple therapy together. I am worried sometimes about the fatigue that patients can have during the first six cycles of docetaxel. So oftentimes, I tell them if they're super fit, I may just do triple therapy up front, but if they I think they're going to struggle, what I tell them is, "Hey, we're going to put you on ADT chemotherapy. Right after you're about to complete chemo, we'll actually add on the darolutamide." So I do it in a sequence, and I think that's part of the data; we just still don't know if it should be given three at front or ADT chemo, followed by immediately, followed by an ARI. So I love to hear if that's how you practice or you perhaps have a different thought process. Dr. Kriti Mittal: So I usually start the process of prior authorization for darolutamide the day I meet them for the first time. I think getting access to giving docetaxel at the infusion center is usually much faster than the few weeks it takes for the prior authorization team to get copay assistance for darolutamide. So, in general, most of my patients start that darolutamide either with cycle two or, depending on their frailty, I do tend to start a few cycles in like you suggested. I've had a few patients that I've used the layered-in approach, completing six cycles of chemotherapy first and then layering in with darolutamide. I think conceptually the role of intensifying treatment with an androgen receptor inhibitor is not just to get a response. We know ADT will get us a PSA response. I think the role of an androgen receptor inhibitor is to prevent the development of resistance. So, delaying the development of resistance will be pertinent to whether we started with cycle one, cycle six, or after. So, we really have to make decisions looking at the patient in front of us, looking at their ECOG performance status, their comorbidities, and frailty, and we cannot use a one-size-fits-all approach. Dr. Jorge Garcia: Yeah, I like that and I concur with that. Thank you for that discussion. I think that you may recall some of our discussions in different venues. When I counsel patients, I tell the patients that really the goal of their care is on the concept of the three Ps, P as in Peter. The first P is we want to prolong your life. That's the hallmark of this regimen, the hallmark of the data that we have. That's the goal, the primary goal of these three indications is survival improvement. So we want to prolong your life so you don't die anytime soon from prostate cancer. The second P, as in Peter, is to prevent, and the question is preventing what? We want to prevent your cancer from growing, from growing clinically, from growing radiographically, and from growing serologically, which is PSA and blood work. Now, you and I know and the audience probably realize that the natural history of prostate cancer is such that traditionally your PSA will rise first. There is a lead time bias between the rise and the scan changes and another gap in time between scans and symptoms. So it's often not the case when we see symptomatic disease preceding scans or PSAs, but sometimes in this case, it's at the same time. So that is the number one. And as you indicated, it's prevention of resistance as well, which obviously we can delay rPFS, which is a composite endpoint of radiographic progression, symptomatic progression, and death of any cause. But the third P is I called it the P and M, which is protecting and maintaining, and that is we want to protect your quality of life while we treat you. And we want to maintain your quality of life while we treat you. So to me, it's critically important that in addition of aiming for an efficacy endpoint, we don't lose sight of the importance of quality of life and the protection of that patient in front of us. Because, undoubtedly, where you get chemo or where you get an oral agent, anything that we offer our patients has the potential of causing harm. And I think it is a balance between that benefit and side effect profile that is so critically important for us to elucidate and review with the patient. And as you know, with the charted data, Dr. Alicia Morgans now at Dana-Farber, published a very elegant paper in JCO looking at the impact of docetaxel-based chemotherapy as part of the charted data in the North American trial and into quality of life. And we clearly define that your quality of life may go down a bit in the first few months of therapy, predictably because you're getting chemotherapy. But at the end of the six months, nine months, and certainly at the end of a year mark, the quality of life data for those who receive ADT and chemotherapy was far better than those who actually got ADT alone. Now, if you look at the quality of data for RSNs, a similar pattern will appear that although chemotherapy is tied to misconceptions of significant toxicity, in our hands, in good hands, and I think our community of oncology in North America are pretty familiar with the side effects and how to manage and minimize side effects on chemotherapy, I think it still requires a balance and a thoughtful discussion to make sure that we're not moving forward chasing a PSA reduction at the expense of the quality of life of the patient. So I think orchestrating that together with the patient as a team is critically important as well. Dr. Kriti Mittal: Thank you, Dr. Garcia. Moving on to the next concept we'd like to discuss in today's podcast the role of PARP inhibitors. Case Two was treated with androgen deprivation docetaxel and darolutamide. Consistent with current guidelines, the patient was also referred to germline testing and was found to be BRCA 2-positive. The patient's disease remained stable for 24 months, at which time he demonstrated disease progression, radiographically and clinically, and his disease was termed castration-resistant. There has been a lot published in the last few years regarding the role of PARP inhibitors in metastatic castration-resistant prostate cancer, or mCRPC. The PROfound trial led to the approval of olaparib in patients with deleterious mutations in HRR genes for those who had been treated previously with AR-directed therapy. The TRITON2 trial led to the approval of rucaparib in the same month for mCRPC patients with BRCA mutation for those patients who had previously been treated with AR inhibitors and taxine-based chemotherapy. More recently, we saw data from the TRITON3 trial exploring the role of rucaparib versus physicians' choice of docetaxel versus AR-inhibitor therapy in the mCRPC space for patients harboring BRCA 1, BRCA 2, or ATM mutation. Based on these data, it would be very tempting to offer a PARP inhibitor to the patient in case two. While regulatory authorities are still reviewing those data for approval, how would you consider treating this newly castrate-resistant patient in the frontline setting? Would you consider a PARP inhibitor in the frontline treatment of mCRPC in this patient with a BRCA 2 mutation? Dr. Jorge Garcia: So that's a loaded question, to be honest with you. We have compelling data, but controversial data, as you know as well. So I think that since we have a genomic profile on this patient and we know he had high volume disease, then the first thought to me is not a genetic or a genomic question or a sequence. It's actually a clinical question, to be honest with you. And that is: How are you progressing? Because I think that if you're progressing serologically, you and I may think of that patient differently. If you're progressing radiographically with alone plus minus PSA production but no symptoms, you may also tilt your scale into this life-prolonging agents in a different way. Whereas if you have true symptomatic disease, knowing what you know, prior therapy, CrPC with a BRCA 2 alteration, then you may actually go for something different. So if it's a rising PSA, if it is radiographic, but the patient is stable clinically, is not basically compromised by symptomatic disease, I do feel that a PARP inhibitor as a single agent would be a very reasonable choice. In this case, you can use, obviously, rucaparib. You can use olaparib. I don't have a vested interest in either/or. I think either/or is fine. The subtleties and side effects, as you know, the olaparib data was probably the data that you and I probably are more accustomed to, used to the most just by virtue of how the agents got registered in the United States. But either/or, I think a PARP inhibitor would be a reasonable approach. I think the question perhaps, and I pitch that back to you, is what are you looking for with a PARP inhibitor? Because, as you know, all DNA repair deficiencies are not biologically the same. They do not respond the same way to PARP inhibitors. And even BRCA 2, where we think it's monoallelic or biallelic, may have subtleties in how those patients respond to PARP therapy. But the answer is yes, obviously, you have a biomarker, the patient has it, you can use it. I think the question is, how are you going to follow the patient? And what is going to be the endpoint that you're going to pay attention to in this case to find that the patient has a benefit or not granted, that could be PSA driven, but I think that perhaps I'm pushing you to think beyond PSA. Dr. Kriti Mittal: I agree, Dr. Garcia. I think we need to think about the patient as a whole. PSA-based changes in treatment are not generally part of our practice. I think evaluating the patient for symptoms and also thinking about the sites of progression, sites of disease they've had in the past, preventing development of cord compression, because some of these patients progress very rapidly and present with cord compression at the time of progression. Those are the things we are trying to predict and prevent. I think in a patient with BRCA 2 mutation, in this situation, I would feel compelled to offer rucaparib, given that even in the intention-to-treat analysis, the hazard ratio was 0.6 in terms of median progression-free survival. I think what was quite impressive was the subset analysis comparing rucaparib versus docetaxel. And that was something surprising. And I think we'll have to wait for long-term outcomes. But certainly, for a BRACA 2-mutated patient, this could be a reasonable consideration provided the drug is available and approved. Dr. Jorge Garcia: As you know, the three most common DNA repair deficiencies that we see are BRCA1, BRCA2, and ATM. BRCA2 is probably the one that we see the most. But we also recognize that with the limited data we have for ATMs, that patients with an ATM abnormality do not tend to benefit the most. And then yet we have also another series of DNA repair deficiencies, deficiencies, PALB2, CHEK2, CDK12 and so forth. And yet we have some exquisite responses to some of those patients. So I can tell you that I have a patient of mine who had an ATM mutation, a germline ATM mutation, and I predicted that initially that the likelihood of benefit to a PARP inhibitor would be low. He was placed on a PARP inhibitor and surprise, surprise, he was on a PARP inhibitor for almost a couple of years. What I want to convey to the audience is that if you have the appropriate biomarker, you certainly should consider a PARP inhibitor in this scenario. I think the bigger question is also understanding that not every DNA repair would benefit the same way. So being very thoughtful and very structured as to how you're going to manage the patient, it cannot be PSA only, the patient has to be followed radiographically and clinically because I would argue that if this patient had just a serologic progression, I would put the patient on a PARP inhibitor and the PSA kinetics change north, but slowly, what is the urgency of you switching the patient to something else? And also the misconception that if you look at PROfound, that olaparib for that matter has to always be given after docetaxel. That's not the case. The makeup of PROfound is different than this patient, obviously, because this patient got triple therapy upfront, whereas most patients on the PROfound were CRPC who receive chemotherapy in the CRPC space. But yet undoubtedly, I think that your case illustrates the importance of next-generation sequencing and the importance of understanding the access to two oral PARP inhibitors that are super solid. I think that perhaps the bigger question is going to be should you do a PARP inhibitor alone or should we use a combination of a PARP inhibitor plus an oral agent, such as in this case, maybe abiraterone acetate plus olaparib. Or maybe even thinking of TALAPRO, maybe enza plus a PARP inhibitor. So I don't know where you sit on those thoughts, Doctor-. Dr. Kriti Mittal: I change toxicity considerations, temper my enthusiasm for offering PARP inhibitors in combination with AR inhibitors or abiraterone at this time. I think I would certainly consider monotherapy with rucaparib for a patient in this situation. I am not entirely convinced that putting a patient through dual treatment in the mCRPC setting in the frontline, I don't think we are there yet. Dr. Jorge Garcia: There are two very important trials that are looking at the combination of an adrenal biosynthesis inhibitor plus olaparib in this context, and one is PROpel and the other one is MAGNITUDE. And both trials have very different results in many ways because they look at patients with a biomarker, meaning DNA repair, and patients without the biomarker. And I think the bigger question is, should this patient who was an abiraterone– Let's say this patient hypothetically was on a PEACE-1-like style. So the patient got ADT or triple therapy but was an abiraterone or an adrenal biosynthesis inhibitor instead of chemotherapy. And the patient was progressing slowly on abiraterone, you knew that the patient had a DNA repair deficiency. How comfortable with the PROpel and MAGNITUDE data would you and I feel to add on or layer, if you allow me to express it like that, a PARP inhibitor into this regime? Dr. Kriti Mittal: My personal interpretation of the currently available data is that at this point, combination therapy is not something I would use in my clinical practice. I think there are two camps in the GU oncology community of how people interpret the PROpel, MAGNITUDE, TRITON, and TALAPRO data in full. I think each of these trials had very different patient populations. I think in a biomarker unselected population, I would certainly not advocate for combination therapy. But even in the biomarker-selected population, I think how the biomarkers were tested and how the populations were defined may not always match what we are doing in clinical practice. And so I would, at this time, advocate for monotherapy over combination therapy. Dr. Jorge Garcia: I'm sure the audience will have probably read or heard about PROpel and MAGNITUDE and the data in patients without a biomarker positivity disease. So I'd love to hear your thoughts as to if you had no biomarker. By that I mean if you had a patient with CRPC, with metastatic CRPC without a DNA repair deficiency, would you consider using an adrenal biosynthesis inhibitor and a PARP inhibitor together based upon the potential synergistic of additive benefits and some of the data to suggest that you can delay rPFS when you combine therapy, but in the absence of biomarker positivity. Dr. Kriti Mittal: In the absence of biomarker positivity, I think the preclinical data are stronger than the clinical results we are seeing in trials. So while I think we should continue researching further into this because there certainly is preclinical rationale, looking at the clinical outcomes from these several trials, I would not offer PARP inhibitor to an unselected patient. Dr. Jorge Garcia: Great. Dr. Kriti Mittal: Moving on to second-line treatment for castration-resistant prostate cancer. I think talking of access issues and talking about the current treatment paradigms in the United States, there is still not widespread availability of lutetium. The listeners would love to hear your thoughts, Dr. Garcia, on practical management tips, safety issues, and the multidisciplinary nature of the management of lutetium therapy. Dr. Kriti Mittal: So I think the challenges with lutetium are multiple. Number one is the correct identification of the patient, the ideal patient for lutetium. Secondly is who manages the patient and as you indicated, the importance of a team approach in that. Thirdly is how do we follow that patient during therapy? So it's beyond the technical aspects of who infuses the patient. Fourthly is what are the true goals of lutetium for that patient population and the side effects that those patients may embark on that some people may not be fully aware of and creates complexity. And lastly, perhaps, is how the movement, how we develop lutetium in CRPC and how we're going to move lutetium or have started to move lutetium and alike, meaning radiopharmaceuticals, radioligand-based therapies outside lutetium opinion and others as you know, earlier into the natural history of prostate cancer, maybe even in the locally advanced disease in combination with radiation or for patients with N1 positive disease. So it's a lot of movement in that space. I think that this is just the beginning of radiopharmaceutical entering diagnostics. But let me just address this succinctly, if I may. Number one, you do need a PET PSMA in order for you to select the patient because we're talking about a potential biomarker. But this is what I call an imaging biomarker. If you see it, you treat it. So the standard of care right now for lutetium is very simple: you need to have men with metastatic castration-resistant prostate cancer. Two, you need to have failed a prior oral agent, in this case, a novel hormonal agent, independent of which agent you have seen, independent of the timing when you have seen an oral agent at the front, the middle, the end. And lastly, you have to have progress through chemotherapy. Yet again, it depends on when you see chemo. So if you have someone who has high volume metastatic disease from the beginning, de novo disease, and you got ADT, daro, and docetaxel, and the patient progresses, that patient can go on. If that patient has a positive PSMA PET, that patient can go on to get lutetium. Similarly, if you have someone who got ADT alone in the adjuvant space for radiation therapy, progress, got an oral agent, progress, got a PARP or not, or got docetaxel, that patient could also be a candidate for lutetium. It's dependent on how you run the patient through therapy. Secondly is who gives lutetium? So I do believe, and I may be biased, I certainly believe in the importance of a team approach with radiation oncology and nuclear medicine. But the reality of it is, I believe these patients are so advanced in their stage of their disease, then the idea of quarterback, in my personal opinion, resides in medical oncology. And I think the bigger question is going to be if nuclear medicine at your given institution is going to be delivering lutetium, or is it going to be radiation oncology? And I think, as you know, in places in America, it's RadOnC, in other places is NucMed, in our institution right now it is NucMed. Having said that, I do predict that for those places where nuclear medicine is heavily involved in delivering lutetium or partnering with MedOnc to deliver lutetium, radiation oncology in the future will have a bigger role as well because we are moving lutetium earlier in settings where radiation oncology is commonly used, such as high-risk prostate cancer patients, or even in the salvage setting, or even in patients with metastatic disease, where we want to combine radiation and lutetium, which are part of clinical trials as we think through for the future. But either/or, I think the quarterback should be really MedOnc in this case. Thirdly is how do we do it? So clearly, at least in my practice, and I think it's probably standard across the United States, MedOnc will see the patient, determine viability and feasibility of therapy, determine who's the ideal candidate, discusses the pros and the cons, and then works along with RadOnc or NucMed to start the process. As you know, it is once every six weeks. So here in my practice, we will see the patient every time before treatment. Sometimes we see them the day off, sometimes we see them a few days before. Patients will get blood work. Specifically, we're interested in seeing everything CMPs, but certainly blood counts, red cell counts, platelets, and white cell counts, just to make sure that patients do not start with impaired bone marrow that can increase the risk for myelosuppression and therefore significant challenges with side effects, hematologic side effects, specifically. And we do that. Sometimes we see them, sometimes our nurse practitioners would do so. And then the patient will basically follow through and complete up to six cycles of treatments. Six times six, that's actually 36 weeks or so. That's a long time on therapy for those who can get six cycles. I think the question becomes how do you follow those patients? And if we pay attention to the VISION data, as you know, those patients were actually followed serially quite closely on trial every eight weeks for the first 24 weeks, and then they stretch the scans out. But the scans that we're using in the trial are conventional imaging. And I think the bigger question that you and I will have is if we get a PET PSMA to use to make that decision to get on lutetium PSMA, should I go back and use a CT or so to stage the patient? I think we're moving more toward PET follow-up, but we also don't know fully the impact of lutetium PSMA on PSMA metabolically during treatment. I think that we all recognize anecdotally and at least with some of the emerging data and we have the SUV may change, that PSA reductions also appear to be important as to define who is likely to benefit or not. But those are questions that remain to be seen, to be honest with you. We follow the patients serologically, clinically, and radiographically. And at least in my group, we tend to do PSMA PETs in between therapy to ascertain the impact of therapy in radiographic and also metabolic changes. And lastly is how we manage side effects. So I think that I'm pretty OCD about these patients because I have seen in my practice patients having outstanding responses to therapy but unfortunately become transfusion dependent, either transiently or permanently, just by virtue of side effects. And I think the importance of understanding the most common side effects of lutetium, in this case fatigue, myelosuppression, xerostomia, are really, really important. And that is the importance of having a multi-team effort approach so everybody is fully aware of the baseline characteristics of that patient or how the patient is enduring therapy and how the therapy is impacting the quality of life and impacting bone marrow production for those patients. I think I remind the audience that the vast majority of our patients do have bone metastases. In fact, in the VISION trial it was around what, over 85, 90% of patients are so with bone metastases. So their marrow has already been impacted not only by disease but equally importantly by the prior chemotherapy that they may have seen. And some of the patients that we have in the first bubble effect is they have seen probably docetaxel, some may even have seen dual therapy with cabazitaxel as a second-line chemotherapy. So I think the understanding as to how you manage the side effects is critically important for our patients as well. Dr. Kriti Mittal: Those are very relevant, practical life issues. Thank you Dr. Garcia for a terrific discussion on the application of recent advances in prostate cancer to clinical practice. [28:54] The ASCO Education podcast is where we explore topics ranging from implementing new cancer treatments and improving patient care to oncologists' well-being and professional development. If you have an idea for a topic or a guest you'd like to see on the ASCO Education Podcast, please email us at education@asco.org. To stay up to date with the latest episodes and explore other educational content, please visit education.asco.org. Dr. Jorge Garcia: Thank you, Kriti. It's great to see you and thanks again to ASCO for the amazing opportunity to be here with you guys today. I hope the audience can see the benefit of understanding how the many changes we have seen have impacted our patients in a positive way. So thank you again for the opportunity. Dr. Kriti Mittal: Thank you, Dr. Garcia, and thank you so much to the ASCO team for inviting me. This was a great experience. Thank you Dr. Garcia for sharing your perspective on incorporating recent research advances into the management of patients with de novo metastatic prostate cancer. The ASCO Education Podcast is where we explore topics ranging from implementing new cancer treatments and improving patient care to oncologists' well-being and professional development. If you have an idea for a topic or a guest you'd like to see on the ASCO Education Podcast, please email us at education@asco.org. To stay up to date with the latest episodes and explore other educational content, please visit education.asco.org. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experiences, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
Farscape 4·21: La Bomba: We're So Screwed, Part 3With their escape from Katratzi botched, the crew of Moya must enlist the help of their old enemy if they hope to survive the Scarrans' wrath.“We gotta get outa here, before they realise.Another lunatic with the wrong number of eyes.Throw a tantrum,Destroy the Crystherium,Leaving a bomb in an elevator seems unwise.” (thanks Ric From the Delta Quadrant!)“Guess what I did at work today, I wore a bomb in a field of flowers... It's not a double cross, It's a triple cross! It's plan E for Elevator, and it has nothing to do with wormholes, despite Harvey's claims. There are sore losers all round and the crew forget to vote” (thanks Marky See!)“The gang partake in gardening practices that are even less environmentally friendly than laying astroturf. Grayza is asked if she could come to the manager's office for a quick chat and Braca is reunited with his brother, his captain, his king, his BESTIE.” (thanks mysterytour!)First aired on Monday, 3 March 2003, written by Mark Saraceni, and directed by Rowan WoodsWe're on Twitter, Facebook, and SoFarscape.com. Our theme music is by Leigh Collier of Give Them L.Send us your synopses, support us on Patreon or suggest a fanfic story for us to read!
Farscape 4·16: Bringing Home the BeaconThe ladies of Moya head for a commerce settlement to purchase a device that will help disguise Moya. The arrivals of several high ranking Peacekeepers and Scarrans, however, give them a new mission and a new threat.“The girls shopping trip quickly goes to dren when they stumble upon a secret meeting. An assassination attempt turns to a hasty retreat, one of the crew is left not feeling quite themselves and why won't anyone tell us where the baby is!?” (thanks Marky See!)“The girls are on their own shopping for a sensor modulator to camouflage Moya. They stumble upon a secret meeting between Grayza, Braca and some high ranking Scarrens. Aeryn and Sikozu spy on the meeting while Chi gets an expensive massage. After, to avoid the peacekeepers, Chi and Noranti get their DNA changed. Aeryn decides to use this opportunity to remove Grayza as a threat permanently. When it's all said and done, Aeryn is a completely different person from when she left Moya.” (thanks Nickrude from Katratzi aka Canada!)“The girls go shopping, and run into a golden opportunity. Will they be able to stop Graza? Will they be able to kill the new Scarran woman? All in all, it goes about like any of their plans. Then, they break the first rule of a horror movie. Never split up.” (thanks Billy Roberts!)First aired on Monday, 27 January 2003, written by Carleton Eastlake, and directed by Rowan WoodsWe're on Twitter, Facebook, and SoFarscape.com. Our theme music is by Leigh Collier of Give Them L.Send us your synopses, support us on Patreon or suggest a fanfic story for us to read!
Today's episode features a story by one of our favorite students, Margery Berger. She has been taking classes with us since way before the pandemic. Margery has told stories on our podcast twice before. Episode 46: An Object Is not Just an Object aired in 2018 features a really compelling story about Margery's obsession with her scale. On Episode 95: What Did It Take to Finally Get Published? Margery told a story about the time her boyfriend said she has ugly hands. That episode is great because we talked to Margery about what holds her back. Margery submitted this story to the Huffington Post and editor Noah Michelson (@NoahMichelson on Twitter) picked it up. Her story is called, I Hated My Breasts and Was Afraid to Show Them to Dates. Here's What Happened When I Did.We also bring you an interview with Noah Michelson who is the head of HuffPost personal and the host of "D Is For Desire," HuffPost's love and sex podcast. Noah gave Margery this note: “What would someone who didn't have your experience learn from reading your story?” Because of Noah Michelson, we're thinking about stories in a new way. Maybe you will too. Margery Berger is the mother of two grown children. She lives in Miami with her two poorly behaved dogs and David. She has written for Home Miami Magazine, Lip Service, Next Tribe and for the Writing Class Radio podcast. Find her on IG: @wherestulipnowWriting Class Radio is hosted by Allison Langer and Andrea Askowitz. Audio production by Matt Cundill, Evan Surminski, Chloe Emond-Lane, and Aiden Glassey at the Sound Off Media Company. Theme music is by Marnino Toussaint.There's more writing class on our website including stories we study, editing resources, video classes, writing retreats, and live online classes. Join our writing community by following us on Patreon. If you want to write with us every week, you can join our First Draft weekly writers groups. You have the option to join Allison on Tuesdays 12-1 ET and/or Zorina Frey Wednesdays 7-8pm ET. You'll write to a prompt and share what you wrote. If you're a business owner, community activist, group that needs healing, entrepreneur and you want to help your team write better, check out all the classes we offer on our website, writingclassradio.com.Join the community that comes together for instruction, an excuse to write, and most importantly, the support from other writers. To learn more, go to www.Patreon.com/writingclassradio. Or sign up HERE for First Draft for a FREE Zoom link.Join the community that comes together for instruction, an excuse to write, and most importantly, the support from other writers. A new episode will drop every other WEDNESDAY. There's no better way to understand ourselves and each other, than by writing and sharing our stories. Everyone has a story. What's yours?See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Talking with Luke Braca on our life challenges that we have overcome and what intensions we have for Portugal Gettogether 2023 --- Send in a voice message: https://podcasters.spotify.com/pod/show/darinaemir/message
Raidījumā Diplomātiskās pusdienas dodamies uz mazu valsti, kas atrodas Centrālāfrikā. Tā ir Kongo Republika. Tā bieži tiek saukta arī par Kongo-Brazavilu vai vienkārši Kongo. Tas tiek darīts, lai atšķirtu to no kaimiņvalsts esošās Kongo Demokrātiskās Republikas. Brazavila, starp citu, ir valsts galvaspilsēta, un tā savu nosaukumu ieguva no franču pētnieka Pjēra Savorgnana de Braca vārda. De Brazza 19. gadsimtā veicināja franču koloniālās intereses reģionā un cīnījās pret verdzību un piespiedu darbu. Kongo Republika oficiāli bija Francijas kolonija no 1891. gada un bija pazīstama kā Francijas Kongo un vēlāk kā Francijas Ekvatoriālā Āfrika. Neatkarību no Francijas valsts ieguva tikai 1960. gadā, un pagājušā gadsimta 70. un 80. gados valsti lielākoties vadīja marksistiska valdība. Vispār Kongo Republika savu nosaukumu ieguvusi no Kongo upes, kas veido ievērojamu daļu no valsts austrumu robežas. Upes nosaukums cēlies no Kongo, Bantu karaļvalsts, kas ieņēma upes grīvu, kuras nosaukums cēlies no tās iedzīvotājiem Bakongo, kas nozīmē "mednieki". Interesants fakts: Kongo Republikas galvaspilsēta Brazavila atrodas Kongo upes krastā pretī Kongo Demokrātiskās Republikas galvaspilsētai Kinšasai. Abas pilsētas atrodas mazāk kā 1,6 km attālumā, padarot tās par tuvākajām galvaspilsētām pasaulē. Jāsaka, gan, ka Roma un Vatikāns atrodas tuvāk, taču, tā kā Vatikāns ir pilsētvalsts, tai tehniski nav galvaspilsētas. Turklāt tā nav ANO dalībvalsts. Kongo Republikā ir daļēji prezidentāla valdības sistēma, kurā prezidents pilda valsts vadītāja pienākumus, bet premjerministrs – valdības vadītājs. Prezidentu ievēl uz pieciem gadiem, un tam nav termiņu ierobežojumu. 2015. gadā valdība ierosināja konstitūcijas grozījumus, kas atcēla prezidenta amata termiņu ierobežojumus, ļaujot kandidēt uz nenoteiktu termiņu. Tieši tādēļ pašreizējais Kongo Republikas prezidents ir Deniss Sassou Nguesso ir bijis pie varas vairāk nekā 35 gadus. Pirmo reizi viņš bija prezidents no 1979. līdz 1992. gadam, bet pēc tam atkal no 1997. gada līdz mūsdienām. Viņa ilgo laiku amatā raksturo apsūdzības par korupciju, cilvēktiesību pārkāpumiem un politiskās brīvības trūkumu. Kongo Republikas valdība ir kritizēta par tās slikto stāvokli cilvēktiesību jomā, tostarp par vārda, pulcēšanās un biedrošanās brīvības ierobežojumiem. Arī politiskās opozīcijas un pilsoniskās sabiedrības grupas ir saskārušas ar valdības drošības spēku vajāšanu un iebiedēšanu. Starp citu, Prezidents Deniss Sassou Nguesso ir apsūdzēts valsts resursu izmantošanā personīga labuma gūšanai un politiskās opozīcijas apspiešanā. Korupcija ir būtiska problēma arī Kongo Republikā. Valdība ir apsūdzēta par ienesīgu līgumu slēgšanu ar uzņēmumiem, kuriem ir cieša saikne ar Sassou Nguesso un viņa tuvāko loku, kā arī par ieņēmumu gūšanu no dabas resursu eksporta. Piemēram, Kongo valdība ir ļaunprātīgi izmantojusi līdzekļus, kas paredzēti Covid-19 palīdzības pasākumiem, šos līdzekļus valdība ir novirzījusi, lai samaksātu par luksusa transportlīdzekļiem, savukārt daudzi veselības aprūpes darbinieki palika bez atalgojuma. Nestabilitāti valstī ir veicinājuši arī reģionālie konflikti, tostarp pilsoņu kara ietekme kaimiņos esošajā Kongo Demokrātiskajā Republikā. 2017. gadā valdība saskārās ar sacelšanos Pūlas reģionā, kas izraisīja ievērojamu vardarbību un pārvietošanos. Papildus šiem politiskajiem jautājumiem Kongo Republika saskaras arī ar vairākiem ekonomiskiem un sociāliem izaicinājumiem, jo valstī ir augsta nabadzība, un vairāk nekā puse iedzīvotāju dzīvo zem nabadzības sliekšņa. Veselības aprūpes un izglītības sistēmas ir nepietiekami finansētas un neatbilstošas, un piekļuve pamatpakalpojumiem, piemēram, tīram ūdenim un sanitārijai ir ierobežota. Tāpat kā daudzas citas pasaules valstis, arī Kongo Republika piedzīvo klimata pārmaiņu sekas, tostarp temperatūras paaugstināšanos, nokrišņu daudzuma izmaiņas un biežāk ekstremālus laikapstākļus. Šīs izmaiņas var būtiski ietekmēt valsts dabisko vidi, lauksaimniecību un ekonomiku. Kongo Republikā ir viena no mitrākajām valstīm pasaulē, relatīvais mitruma līmenis bieži pārsniedz 90%. Šis augstais mitrums var padarīt temperatūru daudz karstāku nekā tā ir patiesībā, un tas var arī veicināt pelējuma un citu veidu sēnīšu augšanu. Ko tas īsti nozīmē, ka mitruma līmenis bieži pārsniedz 90% un kā tas izpaužas un ar ko jārēķinās sabiedrība, skaidro Toms Bricis. Runājot par Kongo Republikas ekonomiku, jāsaka, ka tā ir ļoti atkarīga no naftas un dabas resursiem. Naftas eksports veido vairāk nekā 70% no valsts IKP un aptuveni 90% no tās eksporta ieņēmumiem. Kā viena no lielākajām naftas ražotājām Subsahāras Āfrikā valsts pēdējo desmitgažu laikā ir piedzīvojusi ievērojamu ekonomisko izaugsmi, lai gan šī izaugsme ir bijusi nedaudz nepastāvīga pasaules naftas cenu svārstību dēļ.
Thank you to our sponsor: OZZI Travel Safety OZZI is the best app for solo travel before and during a trip. I have found safer places to stay and saved me hours of time researching with just a few taps. I highly recommend an OZZI Travel Safety Membership for your next trip! Right now, you can get 20% off your OZZI Travel PRO membership when you use TSFTPOD20 on their website. Here's a link with instructions on how to redeem the discount: https://ozzi.app/redeem-a-promo-code-on-our-web-store/ Our guest for this interview is Sara Braca, she is the author of the memoir, When the Church Burns Down, Cancel the Wedding. In this memoir she takes readers along on her post-divorce adventures around the world, sharing a life lived fully – if untraditionally – and proving that joy can always be found in unexpected places. "What makes you, YOU?" After divorce, you may have a lot of questions about your future. You may be wondering if you'll ever get back on track. You're going through this immediate loss, but there's also the loss of what you envisioned in your future. Solo travel became her first step to finding happiness, strength, and peace in her new life.
Welcome to episode 98 of the Girl about the Globe podcast. In this episode, I'm joined by Sara Braca, author of When the Church Burns Down, Cancel the Wedding to discuss travelling after divorce. If you've just come out of a relationship and need some inspiration, this episode is for you. Find out more about Sara and her inspiring new book: sarabracaauthor.com Subscribe to Girl about the Globe and receive a FREE Solo Travel Card with discounts to more than 25+ solo female friendly brands. https://www.girlabouttheglobe.com
Deportres en Comunicante Mx | 17 de Octubre del 2022 En el Deportres de hoy: ¡¡¡Los Padres eliminaron a los Dodgers y están en la serie final de la liga nacional por primera vez desde 1998!!! enfrentarán a los Filies que dejaron en el camino a los campeones Bravos de Atlanta, mientras que los Astros de Houston esperan al ganador entre los Yankees de Nueva York y los Guardianes de Cleveland. En la NFL Buffalo le pego a Kansas City, y los Gigantes hicieron lo propio con los Cuervos de Baltimore,y los patos le tiraron a las escopetas con pittsburgh venciendo a Brady y a los Bucaneros, mientras que Chargers recibirán a los Broncos de Denver en el lunes por la noche. En la liga MX América volvió a abusar del Puebla, toluca eliminó a Santos, Rayados goleó a Cruz Azul, y Pachuca despacho a los Tigres de Miguel Herrera, en la liga de las estrellas Real Madrid derrotó contundentemente al Braca, y revisamos toda la actividad del fútbol internacional, en el futbol femenil con gol de Alex Morgan el Wave eliminó a Chicago y está en las semifinales de la liga profesional de futbol femenil de los Estados Unidos, además basquetbol, tu participación y ¡mucho mas! --- Support this podcast: https://anchor.fm/deportres/support
Empower U Membership http://jjflizanes.com/eu Awaken Your Dream Life http://jjflizanes.com/dreamlife Application for the Coaching Program http://jjflizanes.com/app Shawna Holm, also known as p0etik, is an Intuitive Card Reader and Energy healer, also certified in Reiki, Podcast host, Lightworker and Spiritual Coach. For more got to http://www.wholeeshift.com Stephanie Dillon attained her Bachelors Degree in Nursing from Ashland University and attained her Licensed School Nurse Certification through The Ohio State University. She have been in the healthcare care industry in many different capacities for over 32 years. She has a personal experience with Breast Cancer (strong family history & Braca 1 genetic gene) 2003, 2013 standard of care & 2019 decided to pursue alternative care. http://simplystephaniecoaching.com Megan Banks is a licensed family nurse practitioner and certified yoga teacher. She graduated from the University of Texas in Austin as a registered nurse in 2003. She practiced in-patient psychiatric care at Austin State Hospital in the forensics unit and admissions unit, and then as a charge nurse. She practiced there for 3.5 years before going back to school to become an advanced practice registered nurse. JJ Flizanes is an Empowerment Strategist and the host of several podcasts including People's Choice Awards nominee Spirit, Purpose & Energy. She is the Director of Invisible Fitness, a best-selling author of Fit 2 Love: How to Get Physically, Emotionally, and Spiritually Fit to Attract the Love of Your Life and The Invisible Fitness Formula: 5 Secrets to Release Weight and End Body Shame. Named Best Personal Trainer in Los Angeles for 2007 by Elite Traveler Magazine, JJ has been featured in many national magazines, including Shape, Fitness, and Women's Health as well as appeared on NBC, CBS, Fox, the CW and KTLA. Grab a free copy of the Invisible Fitness Formula at http://jjflizanes.com/book
Empower U Membership http://jjflizanes.com/eu Awaken Your Dream Life http://jjflizanes.com/dreamlife Application for the Coaching Program http://jjflizanes.com/app Shawna Holm, also known as p0etik, is an Intuitive Card Reader and Energy healer, also certified in Reiki, Podcast host, Lightworker and Spiritual Coach. For more got to http://www.wholeeshift.com Stephanie Dillon attained her Bachelors Degree in Nursing from Ashland University and attained her Licensed School Nurse Certification through The Ohio State University. She have been in the healthcare care industry in many different capacities for over 32 years. She has a personal experience with Breast Cancer (strong family history & Braca 1 genetic gene) 2003, 2013 standard of care & 2019 decided to pursue alternative care. http://simplystephaniecoaching.com Megan Banks is a licensed family nurse practitioner and certified yoga teacher. She graduated from the University of Texas in Austin as a registered nurse in 2003. She practiced in-patient psychiatric care at Austin State Hospital in the forensics unit and admissions unit, and then as a charge nurse. She practiced there for 3.5 years before going back to school to become an advanced practice registered nurse. JJ Flizanes is an Empowerment Strategist and the host of several podcasts including People's Choice Awards nominee Spirit, Purpose & Energy. She is the Director of Invisible Fitness, a best-selling author of Fit 2 Love: How to Get Physically, Emotionally, and Spiritually Fit to Attract the Love of Your Life and The Invisible Fitness Formula: 5 Secrets to Release Weight and End Body Shame. Named Best Personal Trainer in Los Angeles for 2007 by Elite Traveler Magazine, JJ has been featured in many national magazines, including Shape, Fitness, and Women's Health as well as appeared on NBC, CBS, Fox, the CW and KTLA. Grab a free copy of the Invisible Fitness Formula at http://jjflizanes.com/book
Empower U Membership http://jjflizanes.com/eu Awaken Your Dream Life http://jjflizanes.com/dreamlife Application for the Coaching Program http://jjflizanes.com/app Shawna Holm, also known as p0etik, is an Intuitive Card Reader and Energy healer, also certified in Reiki, Podcast host, Lightworker and Spiritual Coach. For more got to http://www.wholeeshift.com Stephanie Dillon attained her Bachelors Degree in Nursing from Ashland University and attained her Licensed School Nurse Certification through The Ohio State University. She have been in the healthcare care industry in many different capacities for over 32 years. She has a personal experience with Breast Cancer (strong family history & Braca 1 genetic gene) 2003, 2013 standard of care & 2019 decided to pursue alternative care. http://simplystephaniecoaching.com Megan Banks is a licensed family nurse practitioner and certified yoga teacher. She graduated from the University of Texas in Austin as a registered nurse in 2003. She practiced in-patient psychiatric care at Austin State Hospital in the forensics unit and admissions unit, and then as a charge nurse. She practiced there for 3.5 years before going back to school to become an advanced practice registered nurse. JJ Flizanes is an Empowerment Strategist and the host of several podcasts including People's Choice Awards nominee Spirit, Purpose & Energy. She is the Director of Invisible Fitness, a best-selling author of Fit 2 Love: How to Get Physically, Emotionally, and Spiritually Fit to Attract the Love of Your Life and The Invisible Fitness Formula: 5 Secrets to Release Weight and End Body Shame. Named Best Personal Trainer in Los Angeles for 2007 by Elite Traveler Magazine, JJ has been featured in many national magazines, including Shape, Fitness, and Women's Health as well as appeared on NBC, CBS, Fox, the CW and KTLA. Grab a free copy of the Invisible Fitness Formula at http://jjflizanes.com/book
Empower U Membership http://jjflizanes.com/eu Awaken Your Dream Life http://jjflizanes.com/dreamlife Application for the Coaching Program http://jjflizanes.com/app Shawna Holm, also known as p0etik, is an Intuitive Card Reader and Energy healer, also certified in Reiki, Podcast host, Lightworker and Spiritual Coach. For more got to http://www.wholeeshift.com Stephanie Dillon attained her Bachelors Degree in Nursing from Ashland University and attained her Licensed School Nurse Certification through The Ohio State University. She have been in the healthcare care industry in many different capacities for over 32 years. She has a personal experience with Breast Cancer (strong family history & Braca 1 genetic gene) 2003, 2013 standard of care & 2019 decided to pursue alternative care. http://simplystephaniecoaching.com Megan Banks is a licensed family nurse practitioner and certified yoga teacher. She graduated from the University of Texas in Austin as a registered nurse in 2003. She practiced in-patient psychiatric care at Austin State Hospital in the forensics unit and admissions unit, and then as a charge nurse. She practiced there for 3.5 years before going back to school to become an advanced practice registered nurse. JJ Flizanes is an Empowerment Strategist and the host of several podcasts including People's Choice Awards nominee Spirit, Purpose & Energy. She is the Director of Invisible Fitness, a best-selling author of Fit 2 Love: How to Get Physically, Emotionally, and Spiritually Fit to Attract the Love of Your Life and The Invisible Fitness Formula: 5 Secrets to Release Weight and End Body Shame. Named Best Personal Trainer in Los Angeles for 2007 by Elite Traveler Magazine, JJ has been featured in many national magazines, including Shape, Fitness, and Women's Health as well as appeared on NBC, CBS, Fox, the CW and KTLA. Grab a free copy of the Invisible Fitness Formula at http://jjflizanes.com/book
Empower U Membership http://jjflizanes.com/eu Awaken Your Dream Life http://jjflizanes.com/dreamlife Application for the Coaching Program http://jjflizanes.com/app Shawna Holm, also known as p0etik, is an Intuitive Card Reader and Energy healer, also certified in Reiki, Podcast host, Lightworker and Spiritual Coach. For more got to http://www.wholeeshift.com Stephanie Dillon attained her Bachelors Degree in Nursing from Ashland University and attained her Licensed School Nurse Certification through The Ohio State University. She have been in the healthcare care industry in many different capacities for over 32 years. She has a personal experience with Breast Cancer (strong family history & Braca 1 genetic gene) 2003, 2013 standard of care & 2019 decided to pursue alternative care. http://simplystephaniecoaching.com Megan Banks is a licensed family nurse practitioner and certified yoga teacher. She graduated from the University of Texas in Austin as a registered nurse in 2003. She practiced in-patient psychiatric care at Austin State Hospital in the forensics unit and admissions unit, and then as a charge nurse. She practiced there for 3.5 years before going back to school to become an advanced practice registered nurse. JJ Flizanes is an Empowerment Strategist and the host of several podcasts including People's Choice Awards nominee Spirit, Purpose & Energy. She is the Director of Invisible Fitness, a best-selling author of Fit 2 Love: How to Get Physically, Emotionally, and Spiritually Fit to Attract the Love of Your Life and The Invisible Fitness Formula: 5 Secrets to Release Weight and End Body Shame. Named Best Personal Trainer in Los Angeles for 2007 by Elite Traveler Magazine, JJ has been featured in many national magazines, including Shape, Fitness, and Women's Health as well as appeared on NBC, CBS, Fox, the CW and KTLA. Grab a free copy of the Invisible Fitness Formula at http://jjflizanes.com/book
Joven Braca is a musician who works with trap, hip hop, and other genres. Stephan Coll is a member of the collective Dynamic Frequency. Joven Braca es un músico que trabaja con trap, hip hop y otros géneros. Stephan Coll es un miembro del colectivo Dynamic Frequency. FOLLOW Joven Braca & Stephan Coll on SOCIAL MEDIA: https://www.instagram.com/jovenbraca/ https://www.instagram.com/steph_collpr/ https://www.instagram.com/dynamicfrequencymusic/ https://open.spotify.com/artist/61jGF49OVBk0PUQyMIYe79?si=ef0FYlr9TCWZG-NKxrRwCQ https://open.spotify.com/artist/0GF3DulEoX1Fg4pigg4Hrf?si=2qNE91RzS6mXzO9U3ioPyQ FOLLOW FEN on SOCIAL MEDIA: https://www.facebook.com/fencorrea/ https://www.instagram.com/fencorrea/ https://twitter.com/fencorrea FIND FEN'S Books on Amazon/Spotify/YouTube/Bandcamp: https://www.amazon.com/Fernando-E.-E.-Correa-Gonz%C3%A1lez/e/B07221Q1FY/ref=sr_ntt_srch_lnk_1?qid=1536059902&sr=8-1 https://open.spotify.com/artist/4dUtrVampVxlHJSXNVaTi9?si=i6kqQ3N_Sv-Rlesi48mHrw https://www.youtube.com/fencorrea https://fencorrea.bandcamp.com
Dr. Kara Fitzgerald is on a mission to transform the global healthcare model towards one that is focused on a functional medicine approach to disease prevention and optimal wellness. For the longest time we've praised people for having “good genes,” assuming that their factors of health and longevity are beyond our control. But recent studies are showing that our genes are not our destiny. Science is showing that now, more than ever before, we have control over our own longevity. In this episode, Dr. Kara shares the cutting-edge research that shows how food, exercise, and mental health can physically slow down (and even reverse) aging, and how those changes are more than skin-deep – they carry all the way through to our DNA. You will learn about... Optimizing genetic expression Genetic mutations, BRACA proteins and how we live our software Defining epigenetics DNA methylation efficiency Aging is a huge risk factor for diseases Biological age vs chronological age The diet that supports epigenetic health and the ones that disrupt our genes The importance of the whole food matrix Activities for genetic health Resources: https://www.drkarafitzgerald.com/ (drkarafitzgerald.com) https://youngeryouprogram.com (youngeryouprogram.com) Instagram: https://www.instagram.com/drkarafitzgerald/ (@drkarafitzgerald) Read: https://youngeryouprogram.com/book/ (Younger You: Reduce Your Bio Age and Live Longer, Better) Connect with Kelly: https://kellyleveque.com/ (kellyleveque.com) Instagram: https://www.instagram.com/bewellbykelly/ (@bewellbykelly) Facebook: https://www.facebook.com/bewellbykelly/ (www.facebook.com/bewellbykelly) Be Well By Kelly is a production of http://crate.media (Crate Media)
2:00 What is a plasmalogen 6:00 White matter tracks 7:26 neuron to neuron signaling 9:06 plasmalogen precursors 9:51 Alzheimer's and brain reserve capacities 10:22 bio chemical reserve capacity 13:30 having high plasma allergens is a 30 year life expectancy difference 18:00 autism 19:12 MS 20:38 concussions 21:33 omega-3‘s 21:50 omega 9's 24:40 Why inflammation is a perfect storm and actually feeds upon itself 25:38 rather than trying to suppress the inflammation we want to pull the log out of the fire 29:13 concussions and CTEs 34:15 new advance magnetic resonance imaging called diffuser tensor imaging. Used to measure white matter integrity Now we can actually measure the water inside the copper wire and the water in the white matter sheath around it and the water outside of that 36:29 your brain never recovers from a concussion it just adapts 38:00 omega nine, and acetylcysteine, carnotine 39:09 in animal studies of brain degeneration, if we pre-treat them with plasmalogen precursors, we can't actually cause brain damage 42:42 Amaloyd deposition in Alzheimer brains. Related to membrane structure and function 49:24 disease does not take your health away. Your health goes away and disease comes in 50:45 I actually painted a metaphorical analogy that he said he was going to steal! 52:44 function versus biomarkers or having “Tom Brady on the field” 53:50 functionality is the end all 55:00 plasmalogens and cancer 55:46 the Braca protein 58:20 exercise is bad for you. Recovering from exercise is great for you 1:00:30 the reason fasting is so insanely good for us 1: 11:03 What should we eat to help the plasma legend process 1:12:48 importance of membrane structure and 1:15:50 vision back to where it was when he was in his early 20s 1:17:59 the importance of the prodrome scan 1:23:06 his thoughts on intermittent fasting 1:25:02 Gerber sooth 1:26:00 lactobacillus rheuteri 1:31:24 peptides 1:31:35 Dr William Seeds 1:35:49 how a fighter can protect his or her brain before the battle 1:36:2038 APOE4 geno-type and amoloyd plaque 1:37:05 you can neutralize this genotype 1:45:14 Amaloid plaque is actually a biomarker of plasmalogen deficiency 1:45:28 if you have high plasmalogen levels you have low Amaloyd levels 1:45:34 Plasmalogens turn on the turn on Alpha secretase enzyme 1:46:18 HIGH PLASMALOGENS LEVELS NEUTRALIZE THE GENETIC RISK OF THE APOE4 GENOTYPE 1:51:02 neurofibrillary tangles 1:54:46 changing the bio markers without changing the cause Of the biomarker is done across our medical platform and has virtually no long-term clinical benefit 1:55:58 inflammation 2:04:33 his personal progression in medicine, why he dedicated his life to this and his philosophy 2:28:21 Prodrome Sciences
TD Bank never turned its focus away from growth during the pandemic and the company continues see to see organic and acquisition opportunities, both in and outside of its traditional U.S. retail footprint, according to CEO Greg Braca. In the episode, Braca discussed the company's outlook for growth, including through potential acquisitions, balancing physical distribution with digital channels and the potential threat from fintechs.
#OvarianCancer #BRCAGene #Chemotherapyhttps://www.stepbystepdyslexiasolutions.com/ you tube https://youtu.be/UxkMmA6B3J4BRCA Genetic Mutation Information – Ovarian Cancer ActionWhen do you call it a Miracle? Where has the money we spend on cancer research gone?I didn't see any stories on Ovarian Cancer and the BRCA gene that I was looking for, so I am giving you my story. I believe it will help millions. It will if you share it!Now I am among the cancer survivors, people I have been so proud of. People I refer to are those who suffered in their journey to victory. I am not suffering. I am strong in the Lord and so grateful I have faith in a God who is loving and cares for me. My sister and cousin, mom and grandma did too, but their stories were of pain and suffering.I had a miracle, discovering ovarian cancer with a routine ultrasound and having a successful surgery that got it all out! I call this a miracle, especially when my sister, cousin, mom, and grandma all died of ovarian cancer because they caught it too late.This is a video that shares my journey with the BRCA gene. BRACA is a mutant cancer gene that sits dormant until cancer comes alive. It is caught early with ultrasounds and MRIs. I want to share with people who know of others with ovarian cancer. I want to share my next step – Chemo to kill any microscopic killer cells lurking to take me out. I have a huge call on my life and so do you. Let's not give in to cancer. Get checked early. Here's how and here's what's next. Please like, share and comment on this video and keep it going to help millions in their battle with ovarian cancer.I have an amazing husband of 32 years, amazing kids, and a grandbaby on the way. I have much to live for. So you do! I am Thankful this year for them all. Mostly I am thankful for Jesus, the Author, and Finisher of my faith. Do you know Him?Education is Dr. Cintron's third career, springboarded from subbing in her children's preschool to being a substitute teacher in a mental health hospital. She never dreamed of earning 5 degrees with a call to expose that “Dyslexia is a Trait of Genius!” She's been an educator for over 23 years and a classroom teacher for 10. She earned a Doctorate Degree and two Masters Degrees.Healing Cancer, Healing Ovarian Cancer, Alternatives to Chemotherapy, BRCA GeneAUTHOR OF: A Message of Hope, Hope Music Enhances Reading for Dyslexic Children Dyslexia- A Trait of Genius, Unlock the Genius of Your Dyslexic Child's Mind Prisms of Brilliance, Closing the Achievement Gap and Stopping the School to Prison Pipeline CAREER HIGHLIGHTS Discovered the link between music and reading and how it eases dyslexia Wants to unlock the genius mind of the dyslexic child Created a music app, developed a reading program for dyslexic children Founded a non-profit learning center in 2018, speaker, teacher trainer, author. Podcaster celebrating First Year and 105 episodes Podcast guest on 12 other platformshttps://www.stepbystepdyslexiasolutions.com/
Author MK Meredith dreaded turning 39, the age her own mom was when she died of breast cancer. MK had watched her health, did BRACA tests to look at her level of risk, and held her breath through her 39th year. Two days before her 40th birthday, her doctor delivered the breast cancer diagnosis.A successful romance writer, MK used her writing chops to document her cancer and wellness journey in Not Your Usual Boob.You will learn:Trusting your gut regarding health is critical, even when medical providers are resistant.Self-advocacy and persistence can mean the difference between life and death.When the free information and books distributed by the medical community isn't helpful, write your own, and as MK says,"...Then step forward."For show notes, click HERE
Many had made fun of Al Braca for his faith, but in their final moments he brought light to the darkness that surrounded them. The story of a bond broker at Cantor Fitzgerald, the company which lost the most people on 9/11.
Welcome back to House of Nerd! This week we dive back into The Bad Batch episode 6 Battle Scars! This week Clone Force 99 visit Braca! We have payoff to the Wrecker/implant story and we have a legend return to the animated screen. Jump in and join the conversation! Join us on Facebook: https://www.facebook.com/groups/420213916040128. Join us on Discord: https://discord.gg/mpKa7aY Twitter: https://twitter.com/nerdshouseof?s=21
Neste episódio conversei com Leo Braca, Coordenador de Design de Produto na Hotmart, onde falamos sobre como montar um currículo e portfólio em UX, além de várias dicas para você se sair bem em uma entrevista de emprego como designer. Instagram @papodeux e @designemcamadas.
En Contacto Depotivo, platicamos con el Profesor Jesús Bracamontes de lo que nos espera en la semifinales de la Liga Mx, donde la llave entre celestes y tuzos, parece ser la más complicada.
En Contacto Deportivo, platicamos con Jesús Bracamontes sobre la molestia que provocó lo sucedido con los potosinos, quienes fueron goleados 5-1 por Pachuca, pagarán la multa y Leonel Rocco fue destituído.
Abby Match talks about her breast cancer, the treatment and managing life as a mother and wife with cancer. In addition to sharing Her Story, Abby is raising awareness of how to screen for the Braca mutation. See omnystudio.com/listener for privacy information.
EL BULLIT SONICO 011 w/ Jay Green & Danilo Braca (@danyb) ➡️ Discover our full archive and follow the daily broadcast in high quality streaming on www.rocketradiolive.com
Braca racconta la sua musica: "Sogno Sanremo, Salerno croce e delizia"
Today I'm joined by Jess Fine, Jess lost her Mum to cancer in 2017, we discuss the everlasting impact of cancer, her important work with Myogenes, Health anxiety, and the Braca gene which is a gene that increases the likelihood of developing breast Cancer for a carrier.As always thank you for choosing to listen to this podcast, and thank you for your engagement and willingness to Normalise those tricky conversationsIf you have any thoughts on the episode and want to get in touch with me.My Instagram is @joebellman My email is: livingwithloss.uk@gmail.comFollow on Spotify and subscribe on Apple Podcasts, leaving a cheeky review if you have time.
David Franklin joins Gigi on the show to talk about Farscape, Life and Elvis =) Support this podcast
Caitlyn Brodnick is the sweetest woman you will ever meet, from her adorable, pixie-like voice to her love for her son – she’s adorable and funny and brave and talented. In 2013, Caitlyn won an Emmy Award – yeah, a legit Emmy – for her Glamour docuseries Screw You Cancer, where she documents the experience of undergoing a voluntary double mastectomy after receiving a Braca 1 Diagnosis. Caitlyn is also the author of Dangerous Boobies, a book that proves that you can find humor in everything – even breast cancer. Caitlyn is the co-host of the ScamWow Podcast, where she and her bestie, Sue Smith, discuss so many scams that Caitlyn could probably change careers and become a scam artist herself. You can find Caitlyn on Instagram and Twitter @CaityBrodnick --- Support this podcast: https://anchor.fm/neuroticnourishment/support
Tape from March 1994 Italy Side A and B previously unreleased
Eclectic, glamorous sounds galore, DANYB aka Danilo Braca knows beautiful music! Have you heard Danilo at NYC Standard's Le Bain nightclub? He's a regular there where he spins his signature sound: eclectic genres from around the world connected by the quality of their productions and his unique mixing. Music has always been a major part of Danilo’s life: his father was an avid record collector and a hifi enthusiast, an obvious influence on Danilo’s career path choice. He started DJing at parties in Italy in 1986 at the age of 13, and later worked as a sound engineer in music studios in Rome. 2012 Brought Danilo to NYC, where he founded The Sound of New York City, a web radio dedicated to the music from his adopted home, and a music production studio filled with vintage gear from his father’s collection. Since moving to the US, Danilo built a strong reputation as club DJ, known for his relentless energy, technical expertise and deeply eclectic music selection. It ranges from African rarities to Italo disco, all through the prism of classic old school sounds of Chicago, Detroit, Philadelphia and of course, New York. Starting in 2016 Danilo released five vinyl EP collections of DJ edits, including the acclaimed Busted series. His latest release, the original single “Oh My Lord” featuring Troy Mobiuscollective on saxophone, “Oh My Lord” comes with six exclusive remixes by a dream team of artists including DJ Spinna, DJ Nature, The Revenge, Ashley Beedle, DJ Rocca and Radius Etc. Big thanks to Danilo for all these unique treasures you bring to listeners ear with each mix. Check out more about Danilo here: https://soundcloud.com/danyb And these links as well: Spotify https://open.spotify.com/artist/6RdHCzQAIdynnrzrbu3iB7 Discogs www.tsonyc.com https://www.discogs.com/artist/5637897-danyb https://www.discogs.com/artist/5637897-Danyb https://www.discogs.com/artist/6985234-Danilo-Braca?filter_anv=0&type=Credits https://www.facebook.com/tsonycdanyb/ https://www.instagram.com/danyb2203/ https://www.instagram.com/tsonyc/
In this episode, we pick up where we left off in episode 4. Amber and Ryan attend a reception for a photography exhibition and book launch for RECONSTRUCTED. The book features a series of photographs and interviews with women of all ages, races, and socioeconomic backgrounds, all of whom are breast cancer survivors who have undergone breast reconstruction surgery - and have the scars to prove it. In this episode, you'll meet Chelsey, a 34-year old breast cancer survivor who feels blessed to be alive. You'll also meet Sherrie, a woman in her 70's who discovered that she was a carrier of the BRACA gene and prophylactically removed her breasts - along with her 34-year old daughter. You can learn more about the project at Projectreconstructed.com Special thanks to the Erez Sabag, Allie, Chelsey, Laura and Sherrie for sharing your stories with us.
Breast cancer affects 1 in 8 women. Men are not immune to this either as about 1% of breast cancers occur in males. This episode offers insight into a proactive educational nutritional approach. http://MitchelMD.com As always, this show is educational in nature and the listener must see their regular healthcare practitioner for advice and care. Transcript (machine generated/unedited) [00:00] Welcome to the recharge podcast. This is October and breast cancer awareness month is upon us. I want to share a few statistics just to get things rolling and then I'm going to share a live interview with a patient. I recorded this a little bit ago and edited it out. It's an educational piece. Uh, the, the, uh, content, uh, don't be overwhelmed by the scientific part of it because we'll dive into the specifics of what it means for this particular patient. The takeaway point is that you really need to work hand in hand with your professional to address this issue. Sadly enough, one and eight women in the U s will develop some type of breast cancer over the course of their lifetime. The kicker here as this podcast is geared largely towards men, is that there are about 2,500 cases of invasive breast cancer diagnosed in men in 2018 alone. The risk remains about the same, about one percent or one in $1,000 for men having breast cancer. So I hope you find some value in this episode and as always a message if you have some concerns. And I hope you'll share it because undoubtedly this issue touches you or someone you know or love close friend or family member. [01:04] The title of this one hopefully grabbed your attention, Broccoli and breasts and obviously with breast cancer awareness month and wanted to shed some light on that issue. And, uh, this will be a little bit different episode. I actually have a live patient, um, someone to do the consult with, uh, regarding some breast cancer genetic risks. And so it's a, I'm trying to do my best to keep it a very limited or minimal in terms of the scientific terminology and jargon. I think you'll definitely get some value from it. But, uh, we just want to preface this that breast cancer not only affects women, but also men. There seems to be a rising percentage of men who are affected by breast cancer, somewhere between one and three percent depending on the, uh, the source of the data, but certainly is an issue that affects men as well. [01:50] And so the bottom line is that everybody, or a lot of people know about the breast cancer genes, Braca one and Braca two, that really comprises the minority of risk for breast cancer. Eighty percent comes from another set of genetic markers and these enzymes actually affect how a person processes estrogen estrogen, like many chemicals in the body can be converted into something beneficial or something detrimental. And if it's detrimental, we want to get rid of it. We want to pee it out or filter through the litter, liver or some other type of process to sort of clean it up and, um, minimize the risk of dangerous to the body. And so when a person has some abnormalities in terms of their machinery, their metabolic machinery, how their body processes things, that really can dramatically increase a risk of a condition. And for the purpose of today's podcast, talking about breast cancer. [02:42] And so, you know, depending on how many of these abnormalities show up for a given person or patient, the risks can really go, go up dramatically. And, uh, so in the example for today, this particular patient had five genes that had abnormalities and so her risk is substantially higher and there are specific things that can be done, terms of supplements, fish oil, dietary modifications, um, vitamin C, Glutathione, selenium, selenium, milk thistle, Indole, three carbinol. I've thrown a lot at you right now. I realize that we'll get into some more of that in the discussion in the recorded interview with one of my patients. So I hope you find some value in this. As always, you can reach out to me on twitter at Dr Mitchell and I love to answer your questions and if you're interested in obtaining a, some specific testing for yourself, I can kind of steer you in that direction as well. And so, um, sure to read the blog post that goes along with this, I give you some more information to some, some nuts and bolts that you really want to know in terms of breast cancer and trying to minimize risk. And so I hope you find this beneficial. And as always, I'd love to have a review on itunes from you. If you find some value in what I'm doing and sharing on the project you podcast and hope you have a fantastic week. So let's dive into the interview. [04:03] Thanks so much for uh, allowing me to record this. Um, we'll keep all your information confidential, but as you're well aware, it's breast cancer month and so just wanted to take a few minutes to go over your test. And the test is actually a test that measures how well your body metabolizes or processes estrogen, which is a huge impact in the risk of breast cancer. I think most women know about Braca one and two, which are sort of the genetic inherited breast cancers that everybody worries about from other family members, but that's really the minority of what, what comprises the risk of breast cancer. And so this test that you did, as you remember, was just a simple as swapping the cheek and it measured six different markers. Basically how well your body processes estrogen. I won't get into the specific genetic terms, but basically you can see from your test here, those are the six, six to eight that were measured in this particular test and so, um, the blue is normal, which means your body processes estrogen through that pathway normally and the pink are abnormal, which means that your body's enzymes may not be able to process certain components of estrogen into a, what we call favorable metabolite. [05:15] What that means is basically we can take part of estrogen and make it into something that is easy for your body to get rid of, whether you pee it out or detoxify it through the liver versus something that accumulates in the body and can potentially increase your risk for breast cancer. So that's sort of the test in a nutshell. I don't know if you have any, any specific questions about what you see on the report in front of you? [05:37] I guess, yeah, I do. I'm worried. I see that I have many variants detected and I just like to know if that means that I have breast cancer or, or I'm going to get breast cancer. [05:47] Sure. I mean, it's a, it's a, uh, a multifactoral questions. So let me get. The first thing is, are there other cancers in your family or do you have breast cancer in your family or other? [05:57] A breast and other. [05:59] Okay. And so, I mean, certainly there is a hereditary component of breast cancer. If you have a first degree relative that has breast cancer, that certainly increases the risk. And then there are certain syndromes where there are multiple cancers, for example, like a thyroid cancer combined with several other cancers in one person. So those are fortunately very rare. But to get to the, uh, answer your question is, um, just because you have these markers, that doesn't mean that you have breast cancer or that for sure you're going to get breast cancer. We know that, that, uh, people who have more abnormalities in their, their machinery, if you will, their metabolic machinery that their risk of breast cancer can go up significantly. And so the more abnormalities you have, a certainly a could increase your risk. But the real issue is just to kind of get the head of the, uh, the whole process is that the ability of, of things that you do to yourself and what you put into your body and really has a substantial impact on your risk. [06:57] And what I mean by that is just simple lifestyle things like what you eat, the kind of food you eat, whether you smoke or drink alcohol. I know it sounds like a simple approach to, uh, you know, potentially a fatal and devastating disease such as breast cancer, but it really kind of gets to the heart of the matter of what we call Epi genetics or another word that we throw around is nutrogenomix. And not to get all scientific, but really food is powerful in terms of using food as medicine. And so by changing what you put into your body, you really have the, the ability to impact these abnormalities in. So for example, you know, we, we sort of harp on our kids to eat green vegetables, but by consuming, for example, cruciferous vegetables, Broccoli as an example, you really have the power to sort of turn on and off some of these genetic abnormalities and so just by altering your diet based on specific abnormalities you see there, you really can can take a risk that might be as high as 13 fold and really scale that back down to something more along the lines of just a few percentage of increase risk so it doesn't wipe out the risk, but it certainly can help your body turn on and off some of these, these abnormalities or these abnormal pathways which can really improve your risk, decrease your risk, which is what it's called [08:15] about. As far as as diet goes. Is it, are there other lifestyle changes such as sleep or stress reduction or. [08:24] Yeah, absolutely. I mean straight sleep is critical. Sleep is sort of the starting block. Everybody wants to jump ahead to, you know, can I take a thyroid pill and tired or can I take a pill or a supplement or something to really fix everything, but if you're not sleeping properly, if your body's inflamed, your body can repair itself. And the, uh, effects of sleep deprivation are widespread and detrimental. It's not just fatigue, but also affects the way your body processes sugar and carbohydrates the way you're, you're a growth hormone is able to not repair the damage that occurs to your body throughout the day. And so sleep is sort of the cornerstone or the foundation of health that people often overlook. And then he kind of asked about specific, specific things. I mean, obviously not everybody loves Broccoli and there are some supplements, so there's one called dm or dim pro and it's got a long chemical name for it, but that's basically the active ingredient of Broccoli that you can take in a pill form, um, that sort of a, a proprietary name. [09:20] The other common name that you may have seen before, is it [inaudible] or Indole? Three carbinol. Most people just call it [inaudible]. That's just a simple supplement that you can take on a daily basis to really kind of shut off some of these abnormal pathways and to help your body process estrogen more effectively so that you can. You can turn an estrogen into something that's beneficial not to bore you with the chemistry of it, but when the estrogen passes through the body, it's shunted into different pathways, whether it's a a different chemical structure, there's a four, there's a 16 and I won't get into the specifics of the chemistry, but that really has a huge impact on whether or not this could be a potentially cancer causing substance or is it something that's beneficial and actually decreases your risk for cancer and also it also has an impact on your mental health in bone health as well. So I'm just a few simple changes in your diet can really have a dramatic impact on your longevity. Essentially. That's what this is all about, is avoiding cancer and in increasing your longevity. So I don't know if that makes sense or not. [10:25] Yeah, so basically this report is telling me that I have a higher risk factor for developing breast cancer, but there are things that I can do that can decrease my risk in my daily life as well. Well, [10:39] yeah, absolutely. I think that's sort of the key thing to know is is not that this test gives you a specific roadmap to avoid cancer, but it does point out some things that are problematic in your body. It's. It allows an individualized approach to your diet and your supplements to decrease your cancer risk and so by knowing that you can take steps to implement some of the changes, whether it's, you know, limiting your alcohol to no more than one drink a day. I'm really thinking hard about whether you're going to use a hormone supplementation or considering some people considering in vitro fertilization. The risk for that really dramatically increases in terms of breast cancer, particularly if you have some of these abnormalities where you get huge doses of a female hormones. The body doesn't process and properly and it's converted into the dangerous forms of estrogen which can dramatically increased risk of breast cancer. And other problems, so just knowing the information ahead of time really allows women to make some, some informed decisions about whether they're going to take birth control or if they're gonna use hormones with former hormones and uh, you know, certainly if there's family history of breast cancer, um, abnormal genetics certainly really want to consider and have an intelligent discussion with your fertility specialists, whether in vitro fertilization with the hormones is really the safest option for you. [11:58] I suppose that's something to consider too, when going through menopause and, and some, uh, hormone replacement during that time as well. [12:06] Absolutely. And do you know, depending on the training of the physician in classically trained physicians rely on Oral Estrogens, which has a functional physician, we know that that particularly is a, not the route to go. The topical estrogen is really the safest route in terms of trying to, a decreased risk of complications. Um, we know that oral estrogen can cause blood clots and increased heart disease and obviously very detrimental health effects. We haven't really found that with the topical estrogen. And the other side of the coin is it's always about balance. Estrogen and progesterone are the two primary female hormones and see a lot of women who don't sleep well at night, particularly when they get to the perimenopausal menopausal stage and oftentimes some supplementation with, with oral estrogen, sorry, oral progesterone, oral progesterone, which is safe, can really improve the quality of sleep. So a combination of some topical estrogen cream in oral estrogen is certainly an option to discuss with, uh, what's your personal physician regarding, you know, what's your desired effect is in terms of lifestyle. [13:11] And it also, again, the risk based on what we know about your genetics. So definitely important things to consider. And then the last point I wanted to bring up as we know that you have some abnormalities on your test here, and so what do you do next? And the next step would be to get the urine test, is to look at some of the metabolites of estrogen and see if you have abnormal amounts in these estrogens. It really needs to take the steps now to improve that if you ignore it in and just let the cumulative effects build up, at least in my opinion, the risk of breast cancer and other disasters outcomes certainly as a, as well stated in the literature. So I think just giving patients the information they need to really make some decisions about how they live, what they put in their body, and whether they're going to take supplements to really improve the metabolism and try to decrease some of the risks is, is just, you know, information is powerful. And uh, that was the purpose of this test for you. It's really kind of shed some light given your family history of breast cancer, a use of birth control pills in the past and uh, and some other factors. So, um, do you have any other questions about the report? [14:17] No, I think that pretty much goes over most of it. The questions that I didn't have. Thank you. [14:21] Yeah, and just the, I mean because the recommendation for you based on your report would be to either use dim or I C on a regular basis. Really take a hard look at very your vegetable cruciferous vegetable intake and the alcohol, a limitation you don't smoke, so that's a positive thing and there's some other supplements that, that, uh, we can talk about, uh, in the future that you might want to increase or may want to add to your diet and your regimen to really kind of improve sleep and other things that are, are critical. All right, you thank you so much for spending some time with me today. If you found value in this episode and the show, please share a review in itunes as it really helps the show get discovered. Please share your biggest takeaway, and as always, I want to help you answer the burning questions in your mind. So reach out to me. I mentioned Linda Dot com or on social media wherever you hang out. Make today incredible and I'll see you on the next episode of the recharge podcasts.
We continue our invisible illness and mental health-themed shows with the second installment, and founder, Dominique, brought in special guest, social media influencer and co-founder of The Breasties, Paige More, better known as Paige Previvor. A breast cancer “pre-vivor” or “pre-cancer survivor”, Paige learned she had the BRACA 1 mutated gene and at 24 had a preventative double mastectomy. With Instagram to document her journey, Paige now has over 25,000 followers in less than four years. This activist knows exactly what it can be like to live with an illness that is visible to the entire world, and then invisible while at other parts of the recovery journey. With Dominique, Paige gets to the nitty-gritty on how to become a social media activist, what are the best gifts and ways to offer support to your friends with health struggles, and even plays some Life Tinder on how she feels about illness-promoting t-shirts, illness-themed parties, and those get well soon cards. It’s lots of life hacks, lots of laughs and lots of advocacy tips with two powerhouse young women in the philanthropy world. See acast.com/privacy for privacy and opt-out information.
1. Romeo & Juliet (Acts III, IV & V) Alec R. Constandinos 2. Regrets Darran P 3. Star Dance (SIREN edit) Dealer 4. Como Tu Te Llama? (What Is Your Name) (Dub) Sly Fox 5. Mi Gente (Louie Vega EOL Remix) Hector Lavoe 6. When You Touch - danyb ReVision Splash 7. Save That Magic Feeling - vocal version DJ PIPPI/WILLIE GRAFF 8. Thank You (Maw Mix) Bebe Winans 9. From Now On (Disco Mix) Linda Clifford 10. 151 (Original Mix) Armando 11. Fly On The Windscreen (Extended) Depeche Mode 12. His Perfect Loop Mannmademusic & S3A 13. We Are Steady Rockin' - G&D edit Al “Man” Muntzie And The Embraceables 14. Leaving This Planet - danyb ReVision Charles Earland
A Tribute To Boyd H Jarvis
Grayza barges in on an already crowded two-parter, yet another cast member leaves, and that unforgettably charming rogue Braca has summarily stolen and broken our hearts in this, the 37th episode of ScapeChatz. Reddit user 'LeoChris' sent us a link to the deleted scene from this episode that assuages one of our major problems with Braca's actions: https://youtu.be/KrZP6XexqkE?t=98 Our Moyabag music is "Planet" by Anamanaguchi: anamanaguchi.com Feedback? Questions/Comments? Follow ScapeChatz on Twitter: twitter.com/scapechatz Ask us questions on Tumblr: scapechatz.tumblr.com Follow Allen on Twitter: twitter.com/allenibrahim Follow Magellan on Twitter: twitter.com/justapfluke Email us: scapechatz@gmail.com Or leave a comment on this episode's post at reddit.com/r/farscape.
Everybody gets a new sex pal and muscle friend, we love Rygel times two, and our boy Braca gets his time to shine. By shine of course we mean writhe and fall unconscious. Our Moyabag music is "Planet" by Anamanaguchi: anamanaguchi.com Feedback? Questions/Comments? Follow ScapeChatz on Twitter: twitter.com/scapechatz Ask us questions on Tumblr: scapechatz.tumblr.com Follow Allen on Twitter: twitter.com/allenibrahim Follow Magellan on Twitter: twitter.com/justapfluke Email us: scapechatz@gmail.com Or leave a comment on this episode's post at reddit.com/r/farscape.
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