Podcasts about hyperlipid

Peter Dobromylskyj is a veterinary anaesthetist, surgeon, and nutrition blogger who created the legendary Hyperlipid blog.  Welcome to the Ally Houston Transforms podcast. I'm a former physicist who fixed my brain using nutrition. I now coach people to empower them to do the same. If you or anyone you know could benefit from a mental health tune-up, head over to metpsy.com where myself and psychiatrist Dr. Rachel Brown coach people to better mental health. Peter and I talk about: Fat metabolism vs. glucose metabolism The legendary protons thread Fats that may cause obesity Mitochondria Metabolic flexibility The electron transport chain Metabolic mental health Evolutionary complexity Miki Ben Dor The carnivore advantage vs deep ketosis Starch adaptation in evolution www.metpsy.com

In this episode we explore some new theories of obesity and the croissant diet with Brad Marshall. His background is in molecular biology, food history, a stint at the culinary institute and butchering which gives him a unique perspective and the ability to decipher complex scientific concepts about how our bodies process fats and store energy. Brad posits the reason we get fat is mitochondrial dysfunction from too much polyunsaturated fat in the diet. He has been testing this theory on himself and others in the biohacking community. Did you enjoy today's show? Let me know by leaving me a review for the show on Apple Podcasts, or wherever you are listening from today! Sharing the show with friends or leaving a review helps to much by allowing people to find the show. Watch the interview on You Tube CONNECT WITH CHERYL Website: https://healnourishgrow.com Drinking Ketones: https://hng.shopketo.com Get Notified About the Fat Loss Book: https://heal-nourish-grow-llc.ck.page/ad0a682866 Show Notes: https://healnourishgrow.com/podcastepisodes Instagram: https://www.instagram.com/healnourishgrow Facebook: https://www.facebook.com/healnourishgrow YouTube: https://www.youtube.com/healnourishgrow Pinterest: https://www.pinterest.com/HealNourishGrow TikTok: https://www.tiktok.com/@healnourishgrow Dry Farm Wines: https://www.dryfarmwines.com/healnourishgrow Amazon Store: https://www.amazon.com/shop/healnourishgrow Links to All of My Favorite Products With Discounts: https://healnourishgrow.com/shop CONNECT WITH BRAD Instagram: https://instagram.com/fireinabottle Web: https://fireinabottle.net Low PUFA Pork: https://firebrandmeats.com Twitter: https://twitter.com/fireinabottle Cheryl McColgan: Thanks everyone for joining us today. I have Brad Marshall, who, as you heard in his bio, is a very much a Renaissance man. So welcome, Brad. How are you doing? Brad Marshall: Thank you. Thanks for having me. Cheryl McColgan: Yeah. So you have been making the rounds lately because you have this diet. You sort of created the somewhat controversial, but I love the name of it, 'cause I've always been a big fan of French food, and that is The Croissant Diet. So maybe you could tell us a little bit about your background, how you came to start experimenting with this stuff and how you got interested in The Croissant Diet part. The Croissant Diet and French Paradox Brad Marshall: Sure. And so my... Well, my background dietarily is I've been keto a lot of my life, but I also went to the French Culinary Institute back in the late '90s, I guess, in New York City. And so, as I've been a keto adult, and knowing that that works and seeing that it helps people, I've had to struggle knowing that at the same time, the traditional French diet where they're combining starch with butter, seems to be keeping people thin as well. And I'm a food historian, and I love looking at the dietary history of people in New York State who were mostly dairy farmers back in the day. And looking at people in New York City, even into the '50s and '60s, when you look at those old photos, you can see that everybody is... Almost everyone is universally slim. And not even that they're not fat, but they're really skinny. And you can look at menus of the day and food trends and USDA data, and everyone was combining starch and butter and meat and potatoes, and they stay lean. And then something changed and people started to get fat. And so my thought is that, what changed? Disclaimer: Links may contain affiliate links, which means we may get paid a commission at no additional cost to you if you purchase through this page. Read our full disclosure here. Brad Marshall: And so I started reading the blog Hyperlipid. I gained weight, I was working, I wasn't... I was working a lot, running a farm and a butcher shop, and I wasn't paying very close attention to my diet 'cause I was overwhelmed and I was eating restaurant food and whatever,

Peter Dobromylskyj is a veterinarian who was trained at the Royal Veterinary College within London University. He is very well-respected in the nutrition world for his blog, Hyperlipid, where he dives deep into the science behind what we should be eating.   GET THE MEAT! http://NosetoTail.org GET THE FREE SAPIEN FOOD GUIDE! http://Sapien.org 15% Redmond salt, toothpaste, Re-Lyte, etc   SHOW NOTES [1:20] His background as a veterinarian. [2:30] The massive difference between science and medicine. [5:40] John Yudkin's work. [10:30] Saturated fat vs. Polyunsaturated fat. [18:00] Are medical professionals giving the absolutely wrong advice? [28:00] Problems with the carbohydrate-insulin model of obesity. [31:30] Can you eat plenty of fruit and honey if you're not consuming linoleic acid? [36:00] Peter's blog Hyperlipid and his overarching ideas. [41:30] You can't just be hungry forever. [49:00] Why Peter loves rodent studies. [55:00] How much linoleic acid should we be consuming? [1:00:00] Can insulin sensitivity make you fat? [1:05:00] Insulin resistance is your body's way of protecting you. [1:11:00] Nobody has all the answers. [1:16:30] Free fatty acids & ketogenic diets. [1:26:40] Macros become less important when linoleic acid is eliminated. [1:29:00] The carnivore trap. [1:35:30] Feeding the world with animal products.     GET THE MEAT! http://NosetoTail.org GET THE FREE SAPIEN FOOD GUIDE! http://Sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg  

Peter Dobromylskyj is a UK-based veterinary anaesthetist and nutrition blogger whose blog Hyperlipid is amongst the longest-running and most highly respected in the low-carb and ancestral health communities. Peter has been writing about the biochemistry of nutrition since 2006, and has authored over 800 posts aimed at reviewing, analysing, and interpreting nutrition literature. Given his outside-the-box thinking and unconventional approach to metabolism and health, Peter's work has amassed a large and devoted following. Today, NBT Scientific Director Megan Hall interviews Peter to talk about insulin resistance, including the factors that cause it and why the condition is actually physiologically adaptive. Peter compares dietary saturated fats to polyunsaturated fatty acids (PUFAs), and explains why the scientific literature can be misleading when determining which truly promotes health. He gives specific science-based recommendations for how much PUFA to include in your diet, and also offers advice on what to feed your pets. For additional resources on insulin resistance and the influence of dietary fat sources, be sure to see the outline Megan wrote to prepare for this podcast. Here's the outline of this interview with Peter Dobromylskyj: [00:01:52] Insulin resistance is physiologically adaptive. [00:02:23] Reactive Oxygen Species (ROS) as signaling molecules. [00:04:52] Dr. David Speijer, Researcher at the University of Amsterdam. [00:05:31] Dr. Nick Lane, Professor of Evolutionary Biochemistry. [00:11:29] Protons thread on the Hyperlipid blog. [00:22:58] When insulin sensitivity becomes insulin resistance. [00:30:37] How long it takes to become insulin resistant. [00:34:55] Acipimox reduces free fatty acid circulation and temporarily reverses insulin resistance; 1. Santomauro, A. T., et al. "Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects." Diabetes 48.9 (1999): 1836-1841; 2. Aday, Aaron W., et al. "Impact of Acipimox Therapy on Free Fatty Acid Efflux and Endothelial Function in the Metabolic Syndrome: A Randomized Trial." Obesity 27.11 (2019): 1812-1819. [00:36:19] Effects of caffeine on insulin resistance. [00:37:34] Phil Maffetone. [00:38:25] In mice, stearic acid reduces visceral adipose tissue; Study: Shen, Ming-Che, et al. "Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice." PLoS one 9.9 (2014): e104083. [00:38:34] Overfeeding studies in humans: 1. Rosqvist, Fredrik, et al. "Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans." Diabetes 63.7 (2014): 2356-2368; 2. Iggman, David, et al. "Association of adipose tissue fatty acids with cardiovascular and all-cause mortality in elderly men." JAMA cardiology 1.7 (2016): 745-753. [00:44:10] Raphael Sirtoli's Podcast: Carnivore Cast. [00:45:02] Butter fat → higher postprandial levels of FFAs and triglycerides; Study: López, Sergio, et al. "Distinctive postprandial modulation of β cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids." The American journal of clinical nutrition 88.3 (2008): 638-644. [00:46:50] Tucker Goodrich. [00:47:38] How much polyunsaturated fat is needed to cause metabolic dysfunction? [00:48:27] Leptin-deficient mouse study: Reeves, Valerie Lynn. "A diet enriched in stearic acid protects against the progression of type 2 diabetes in leptin receptor deficient mice (DB/DB)." (2012). [00:49:57] Aim for 2-4% of calories from linoleic acid (over 8% is obesogenic). [00:51:26] Efforts to lose weight with unsaturated vs. saturated fat stores. [00:53:29] Animal based keto with 15% polyunsaturates; Study: Hall, Kevin D., et al. "Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake." Nature Medicine 27.2 (2021): 344-353. [00:58:46] Electron transport chain (see this figure) and mitochondria. [00:58:57] Summary so far. [01:01:33] What dogs/pets should be eating. [01:09:05] Labradors may have problems with leptin signaling; Book: Raw Meaty Bones Promote Health, by Tom Lonsdale.

In this special podcast, David Gornoski sits down with Peter Dobromylskyj, veterinary anesthetist and nutrition blogger at Hyper Lipid. David and Peter talk about the difference between running metabolism on glucose and running metabolism on fat; the purpose of insulin resistance; the role of reactive oxygen species; the difference between monounsaturated fat and polyunsaturated fat; the harmful effects of vegetable and seed oils; the benefits of carnivore diet; and more. Is it beneficial to consume a mixed diet while avoiding PUFAs (polyunsaturated fatty acids)? In what ways are stearic acids beneficial? How do our cells handle long-term seed oil consumption? Is sugar or seed oils the primary driver of the modern metabolic syndrome epidemic? Is visceral fat bad for us? Visit Peter Dobromylskyj's blog Hyperlipid. Check out David Gornoski's radio shows, podcasts, and films at A Neighbor's Choice here.

Lisa Bailey is a nutritionist, health coach & personal trainer here in Scotland. She also is a carnivore who eats no food from plants, no fruits or vegetables at all. We discuss: Lisa's ill health from childhood 27 years of vegetarianism Sense of smell and taste coming back after 20 years after switching to carnivore Bottle feeding vs breast feeding, Nick Mailer's talk - https://www.youtube.com/watch?v=EVGjIlZSsk4 Peter from Hyperlipid on formula - https://high-fat-nutrition.blogspot.com/2008/01/casein-vs-gluten.html Gut permeability - Dairy & Gluten Peer pressure and diet “normality” Carnivore for everyone? Healthy micro biome Doctors and their understanding of “invisible” illnesses Cold vs hot food Home smoked fat, suet, and bone marrow Eating offal Lisa can be found at: Facebook - facebook.com/lisabaileyhealth Twitter - twitter.com/lbaileyhealth Website - lisabaileyhealth.com Ally can be found at: Twitter - https://twitter.com/paleocanteen Twitter - https://twitter.com/paleoally Instagram - https://www.instagram.com/paleocanteen YouTube - https://www.youtube.com/c/AllyHouston

This stuff is technical but critically important to understanding the possible underlying mechanisms by which excess PUFA may be hurting you. If this is confusing you may want to start with the first episode Peter and I did, all of which are at heartandsoil.co.    Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop. Time Stamps:   0:14:04    Podcast Begins 0:14:46    Last Episode Recap 0:17:20    Why PUFAs drive obesity 0:22:43    Inappropriate insulin sensitivity 0:31:14    Why we have mitochondria 0:41:26    Being right on Q: shaping eukaryotic evolution    https://pubmed.ncbi.nlm.nih.gov/27834740/ 0:44:14    Mitochondrial satiety signaling 0:50:38    The glycerol phosphate shuttle 1:08:54    Reverse electron transport generating ROS 1:13:58    The Krebs cycle explained 1:22:59    Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692813/ 1:23:58    Are carbs the root-cause of metabolic dysfunction? 1:30:31    Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase    https://www.researchgate.net/publication/262529290_Metformin_suppresses_gluconeogenesis_by_inhibiting_mitochondrial_glycerophosphate_dehydrogenase 1:38:47    Metformin (01) Insulinhttps://high-fat-nutrition.blogspot.com/2017/07/metformin-01-insulin.html 1:44:29    Optimizing satiety with saturated fat and glucose 1:49:50    Where to Find Peter    https://high-fat-nutrition.blogspot.com/ 1:50:34    The fates of Pyruvate 1:52:02    Diets could prevent many diseases    https://link.springer.com/article/10.1007/s11745-003-1066-0 1:52:52    Metabolism and longevity: Is there a role for membrane fatty acids?     https://academic.oup.com/icb/article/50/5/808/639943 Heart & Soil: www.heartandsoil.co    Cinder: cindergrill.com/pages/carnivoremd,   Chilipad/ Ooler: https://www.chilitechnology.com//CarnivoreMD   White Oak Pastures: www.whiteoakpastures.com code CarnivoreMD for 10% off first order   Belcampo: www.belcampo.com code CarnivoreMD for 20% off BluBlox: www.blublox.com, code CarnivoreMD for 15 % off

If you missed yesterday's controversial thoughts podcast/video, you might also want to check that one out. I had a few ideas I wanted to discuss on COVID after I finished recording and knew I had to do another. The concept of "long COVID" is increasingly discussed today, but I'm not convinced this is anything new. First, it was "healthy" people (sadly) suffering from COVID who were obese or likely had metabolic dysfunction, and I think it's the same issue now. The majority of those with underlying metabolic dysfunction DON'T know they have it, which is why discussions of this are so important.   If you're new here and don't know what I mean by metabolic dysfunction, this might be thought of as insulin resistance, though that terminology is imprecise. Listen to the podcast next Tuesday (Fundamental Health) for part 2 with Peter from Hyperlipid to hear more discussion of this, or listen to the many podcasts I've done discussing it previously.   Take away: Long COVID is an underlying, undiagnosed metabolic illness IMO. Be metabolically healthy.#thremembering  

Brad Marshall is a former cancer researcher who now raises and sells the meat from pigs raised in a very special way that he sells on FirebrandMeats.com We talk about: Brad's genetics and cancer research background His interest in food and move into farming How pig breed and feed dictates fat content Corn in USA vs barley in northern Europe and northern USA Brad's struggles with weight and use of Atkins / keto The Hyperlipid blog Linoleic acid danger and abundance of it in the restaurant industry Valerie Reeves' thesis on stearic acid leading to The Croissant Diet The protons thread on Hyperlipid explained in more simple terms Why saturated fat is so good for satiety vs. linoleic acid being so bad Why carbohydrates per se are not the main problem The Croissant Diet as the other French paradox The hypothalamus Why calories in calories out is so simplistic The recent history of making pigs more lean Traditional people would go to great lengths to remove PUFA from foods Lack of diversity on farms Valerie Reeves' thesis - https://uknowledge.uky.edu/physiology_etds/3/ Brad can be found at: Blog - https://fireinabottle.net/blog/ Twitter - https://twitter.com/fire_bottle Instagram - https://www.instagram.com/fireinabottle Website - https://firebrandmeats.com Ally can be found at: Twitter - https://twitter.com/paleocanteen Twitter - https://twitter.com/paleoally Instagram - https://www.instagram.com/paleocanteen YouTube - https://www.youtube.com/c/AllyHouston

Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop.   Time Stamps:   0:08:42  Podcast Begins 0:09:52  Peter's Background 0:16:36  The Electron Transport Chain 0:45:30  Insulin resistance is a cellular antioxidant defense mechanism   https://www.pnas.org/content/106/42/17787 0:47:50 High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates   https://www.researchgate.net/publication/5929069_High_rates_of_superoxide_production_in_skeletal-muscle_mitochondria_respiring_on_both_complex_I-_and_complex_II-linked_substrates 0:49:50  We need insulin resistance 0:54:53  All about a1a 1:00:37  How PUFAs affect mitochondria 1:02:40  PUFAs and cellular lipid accumulation 1:05:34  Pathological insulin sensitivity   1:07:52  Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4  https://www.sciencedirect.com/science/article/abs/pii/S1388198107002296?via%3Dihub 1:12:34  The center of metabolic health: the adipocytes  1:14:08  PUFAs and tumor growth 1:15:52  Eating the perfect ratio of fatty acids 1:20:18  Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets  https://academic.oup.com/jcem/article/89/4/1641/2844241 1:20:18  How PUFAs break your metabolism 1:23:20  Premature Atherosclerosis Associated With Monogenic Insulin Resistance  https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 1:25:21  Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/ 1:30:16  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/ 1:30:53  Context matters in interpreting lipids 1:36:49  You might want to rethink your avocado and olive oil 1:40:17  Plant are not benevolent 1:47:55  How to find Peter Dobromylskyj 1:51:01  Peter's radical running habits 1:53:54  Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet   https://www.cambridge.org/core/product/identifier/S0007114502000673/type/journal_article 1:55:42  The roots of the chronic disease epidemic 1:58:23  Diet Fat Composition Alters Membrane Phospholipid Composition, Insulin Binding, and Glucose Metabolism in Adipocytes from Control and Diabetic Animals  jbc.org/content/265/19/11143.long 1:59:29 Insulin-sensitive obesity   https://journals.physiology.org/doi/full/10.1152/ajpendo.00586.2009?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Heart & Soil is my passion based company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand and developing a US based supply chain. Check us out at: www.heartandsoil.co, @heartandsoilsupplements on Instagram  Belcampo: www.belcampo.com Use the code “carnivoremd” for 20% off your order!  Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order White Oak Pastures: Use the code CARNIVOREMD at www.whiteoakpastures.com for 10% off your first order!

Brad Marshall is the author of the Blog Fire In A Bottle and the creator of The Croissant Diet. Mildly obsessed with food and its history, his work focuses on trying to place current ideas about diet, including keto and carnivore diets into the framework of traditional Dietary patterns. For instance, the French diet before 1970 combined flour, sugar, butter and wine and the population was lean. Brad wrote The ROS Theory of Obesity which posits that ROS generation in the mitochondria of fat cells could provide the mechanism that explains why a traditional Chinese peasant diet - low fat with 85% of calories from starch; a French diet combining butter, wine and flour and a modern keto diet could all be expected to produce leanness but combining flour with polyunsaturated fats is a recipe for obesity. The core idea comes from the Protons thread of Peter Dobromylskyj’s blog Hyperlipid. Brad tested this hypothesis with his dietary experiment The Croissant Diet. Brad is also the founder of Firebrand Meats, which is dedicated to producing pork and poultry products that are low in Linoleic acid, the n6 polyunsaturated fat (PUFA) whose intake has seen a dramatic worldwide increase in the last century. Animals cannot make PUFA and so we can create pork and chicken that is nearly free of them. You are what your animals eat. Brad has a genetics degree from Cornell, a certificate from The French Culinary Institute, has studied cancer at Memorial Sloan-Kettering Cancer center and worked as a programmer for the Berkeley Drosophila Genome Project. He spent the last 15 years raising rotationally grazed pastured pork on his farm in upstate New York while running a butcher shop, local food restaurant and USDA inspected meat processing facility. You can find Brad at https://fireinabottle.net/, FB: https://www.facebook.com/fireinabottleO2/, and Twitter: https://twitter.com/fire_bottle. This episode is hosted by Dr. Shawn Baker MD. Find him at https://shawn-baker.com

Brad Marshall is the author of the Blog Fire In A Bottle and the creator of The Croissant Diet. Mildly obsessed with food and its history, his work focuses on trying to place current ideas about diet, including keto and carnivore diets into the framework of traditional Dietary patterns. For instance, the French diet before 1970 combined flour, sugar, butter and wine and the population was lean. Brad wrote The ROS Theory of Obesity which posits that ROS generation in the mitochondria of fat cells could provide the mechanism that explains why a traditional Chinese peasant diet - low fat with 85% of calories from starch; a French diet combining butter, wine and flour and a modern keto diet could all be expected to produce leanness but combining flour with polyunsaturated fats is a recipe for obesity. The core idea comes from the Protons thread of Peter Dobromylskyj’s blog Hyperlipid. Brad tested this hypothesis with his dietary experiment The Croissant Diet. Brad is also the founder of Firebrand Meats, which is dedicated to producing pork and poultry products that are low in Linoleic acid, the n6 polyunsaturated fat (PUFA) whose intake has seen a dramatic worldwide increase in the last century. Animals cannot make PUFA and so we can create pork and chicken that is nearly free of them. You are what your animals eat. Brad has a genetics degree from Cornell, a certificate from The French Culinary Institute, has studied cancer at Memorial Sloan-Kettering Cancer center and worked as a programmer for the Berkeley Drosophila Genome Project. He spent the last 15 years raising rotationally grazed pastured pork on his farm in upstate New York while running a butcher shop, local food restaurant and USDA inspected meat processing facility. You can find Brad at https://fireinabottle.net/, FB: https://www.facebook.com/fireinabottleO2/, and Twitter: https://twitter.com/fire_bottle. This episode is hosted by MeatRx coach Brooke. Find her at https://meatrx.com/product/brooke-erdman/

Etwa 20-30 Millionen Menschen in Deutschland leiden an Bluthochdruck. Als Folge kann es zu atherosklerotischen Folgeerkrankungen wie Herzinsuffizienz, periphere Verschlusskrankheit, Herzinfarkt oder Schlaganfall. Primäre Hypertonie wird auch als „Wohlstandskrankheit“ betitelt und ist meistens eine Folge aus Übergewicht, Diabetes mellitus Typ 2, Hyperlipidämie, Umweltfaktoren und wenig Bewegung. Zusammen mit Rauchen ist das metabolische Syndrom der wichtigste Faktor bei der Entstehung von Bluthochdruck. In dieser Episode spreche ich über: - Systolischer vs. Diastolischer Blutdruck - Diagnose von Bluthochdruck - Ursachen von Bluthochdruck - Symptome von Bluthochdruck - Folgen von Bluthochdruck - Ernährung bei Bluthochdruck - DASH-Diät - Ornish-Diät Verwendete Quellen: Basiswissen: Elmadfa & Leitzmann: Ernährung des Menschen (5. Auflage) Biesalski et al.: Ernährungsmedizin (5. Auflage) DASH-Diät: https://www.ncbi.nlm.nih.gov/pubmed/23466047/ https://www.ncbi.nlm.nih.gov/pubmed/26622263 https://www.ncbi.nlm.nih.gov/pubmed/21058045 https://www.ncbi.nlm.nih.gov/pubmed/23473733 https://www.ncbi.nlm.nih.gov/pubmed/9099655 https://www.ncbi.nlm.nih.gov/pubmed/25149893 https://www.ncbi.nlm.nih.gov/pubmed/10410299 Ornish-Diät: https://www.ncbi.nlm.nih.gov/pubmed/15632335 https://www.ncbi.nlm.nih.gov/pubmed/17341711 https://www.ncbi.nlm.nih.gov/pubmed/28604251 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693202/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577766/ https://www.ncbi.nlm.nih.gov/pubmed/12052487 https://www.ncbi.nlm.nih.gov/pubmed/22332096 Ich freue mich, dich nächstes Mal wieder begrüßen zu dürfen. Lass gerne eine Rezension da, wenn dir mein Podcast gefällt. Kontakt: hallo@sattesache.de https://sattesache.de https://instagram.com/sattesache

Peter Dobromylskyj is a veterinary anaesthetist and nutrition blogger, whose blog Hyperlipid is renowned in the low carb world. We talk about: The "Optimal Diet" The carnivore diet The legendary "Proton" series of posts from Hyperlipid Species appropriate diets for humans and other animals And more! Peter can be found at: Blog - http://high-fat-nutrition.blogspot.com/ Ally can be found at: Twitter - https://twitter.com/paleocanteen Twitter - https://twitter.com/paleoally YouTube - https://www.youtube.com/c/AllyHouston

Ivor Cummins is a Biochemical Engineer who in 2012 was disturbed by a set of his own abnormal blood test results. Consultation with multiple doctors yielded little insight into the cause of his elevated cholesterol, ferritin and GGT so he turned to his analytical roots to study the problem. In the process, he evaluated hundreds of scientific papers, ultimately concluding that that flawed hypotheses and a breach of the scientific method have resulted in the current “diabesity” epidemic. Ivor is here today with Dr. Tommy Wood talking on topics related to his well-referenced new book, Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Great Health. They also discuss the trouble with polyunsaturated oils, advice on fat loss for the insulin sensitive, and the best test for cardiovascular disease risk (hint: it’s not LDL). If you enjoy this podcast, Ivor is a regular presenter at low-carb/keto events and maintains an active blog and social media presence. Here’s the outline of this interview with Ivor Cummins: [00:00:17] Keto Summit, Dave Feldman. [00:00:48] Boundless Health Podcast with Dr. Bret Scher. [00:01:57] Podcast: The True Root Causes of Cardiovascular Disease, with Dr. Jeffry Gerber. [00:02:15] Book: Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Great Health, by Ivor Cummins and Jeffry Gerber, MD. [00:02:29] Videos: here and here. [00:03:20] Insulin, IGF-1, acellular carbs. [00:03:56] Sunlight exposure, 25-OH-D video. [00:04:37] Minerals, Study: DiNicolantonio, James J., James H. O’Keefe, and William Wilson. "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis." Open Heart 5.1 (2018): e000668. [00:05:28] Gabor Erdosi, Lower Insulin Facebook Group. [00:05:43] Video: Roads to Ruin? from Physicians for Ancestral Health 2017 conference. [00:06:01] Guðmundur Jóhannsson, gut health; Podcast: Foodloose Iceland. [00:07:40] Study: Schwalfenberg, Gerry K., and Stephen J. Genuis. "The importance of magnesium in clinical healthcare." Scientifica 2017 (2017). [00:08:10] Industrial seed oils. [00:09:05] Unilever sells its margarine business. [00:10:17] Studies: Alvheim, Anita Røyneberg, et al. "Dietary Linoleic Acid Elevates the Endocannabinoids 2‐AG and Anandamide and Promotes Weight Gain in Mice Fed a Low Fat Diet." Lipids 49.1 (2014): 59-69. And: Alvheim, Anita R., et al. "Dietary Linoleic Acid Elevates Endogenous 2‐AG and Anandamide and Induces Obesity." Obesity 20.10 (2012): 1984-1994. [00:10:48] Studies: Nanji, Amin A., and Samuel W. French. "Dietary factors and alcoholic cirrhosis." Alcoholism: Clinical and Experimental Research 10.3 (1986): 271-273. And: Kirpich, Irina A., et al. "Alcoholic liver disease: update on the role of dietary fat." Biomolecules 6.1 (2016): 1. [00:12:09] Book: Deep Nutrition: Why Your Genes Need Traditional Food, by Cate Shanahan, M.D. [00:12:45] Studies: 1. Ramsden, Christopher E., et al. "The Sydney Diet Heart Study: a randomised controlled trial of linoleic acid for secondary prevention of coronary heart disease and death." The FASEB Journal 27.1 Supplement (2013): 127-4. 2. Frantz, Ivan D., et al. "Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey." Arteriosclerosis, Thrombosis, and Vascular Biology 9.1 (1989): 129-135. 3. Strandberg, Timo E., et al. "Mortality in participants and non-participants of a multifactorial prevention study of cardiovascular diseases: a 28 year follow up of the Helsinki Businessmen Study." Heart 74.4 (1995): 449-454. 4. Rose, G. A., W. B. Thomson, and R. T. Williams. "Corn oil in treatment of ischaemic heart disease." British medical journal 1.5449 (1965): 1531. [00:13:47] Study: Hooper, Lee, et al. "Reduction in saturated fat intake for cardiovascular disease." The Cochrane Library (2015). [00:15:28] Study: Ip, Clement, Christopher A. Carter, and Margot M. Ip. "Requirement of essential fatty acid for mammary tumorigenesis in the rat." Cancer Research 45.5 (1985): 1997-2001. [00:16:28] Study: Pearce, Morton Lee, and Seymour Dayton. "Incidence of cancer in men on a diet high in polyunsaturated fat." The Lancet 297.7697 (1971): 464-467. [00:16:56] Breast milk composition is now almost 50% PUFA. [00:17:50] David Bobbett. [00:19:59] Book structure. [00:20:51] Fat-loss for the insulin sensitive. [00:21:10] Videos: Jeff Gerber interviews Simon Saunders and Marty Kendall. [00:23:03] Ghrelin. [00:24:21] Protein and lean body mass. [00:26:05] Glucagon, mTOR. [00:26:22] Ron Rosedale. [00:26:34] Valter Longo. [00:27:02] IGF-1 U-shaped curve. [00:28:06] Study: Levine, Morgan E., et al. "Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population." Cell metabolism 19.3 (2014): 407-417. [00:28:49] Book: Protein Power: The High-Protein/Low Carbohydrate Way to Lose Weight, Feel Fit, and Boost Your Health - in Just Weeks! By Michael Eades and Mary Dan Eades. [00:30:39] Study: Levine, Morgan E., et al. "Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population." Cell metabolism 19.3 (2014): 407-417. [00:31:06] NHANES. [00:31:18] Study: Cohen, Evan, et al. "Statistical review of US macronutrient consumption data, 1965–2011: Americans have been following dietary guidelines, coincident with the rise in obesity." Nutrition 31.5 (2015): 727-732. [00:32:20] Kitavans. [00:34:05] Hyperlipid and Denise Minger. [00:36:37] Icelandic diets for longevity [00:39:07] Cardiovascular disease. [00:39:35] Basic lipid panel. [00:39:45] Study: Castelli, William P. "Lipids, risk factors and ischaemic heart disease." Atherosclerosis 124 (1996): S1-S9. [00:40:24] Ratios. [00:41:54] Study: Johnson, Kevin M., David A. Dowe, and James A. Brink. "Traditional clinical risk assessment tools do not accurately predict coronary atherosclerotic plaque burden: a CT angiography study." American Journal of Roentgenology 192.1 (2009): 235-243. Commentary: Ware, William R. "The mainstream hypothesis that LDL cholesterol drives atherosclerosis may have been falsified by non-invasive imaging of coronary artery plaque burden and progression." Medical hypotheses 73.4 (2009): 596-600. [00:42:30] Familial Hypercholesterolemia and CVD. [00:43:27] cholesterolcode.com, remnant cholesterol, Plasma Atherogenic Index. [00:44:36] Podcast: Health Outcome-Based Optimal Reference Ranges for Cholesterol [00:46:06] Coronary calcium scan. [00:46:25] Study: Nasir, Khurram, et al. "Interplay of Coronary Artery Calcification and Traditional Risk Factors for the Prediction of All-Cause Mortality in Asymptomatic Individuals Clinical Perspective." Circulation: Cardiovascular Imaging 5.4 (2012): 467-473. [00:47:54] Longitudinal score. [00:49:41] Plaque density. [00:50:11] Interview with Matt Budoff. [00:52:37] Video: Dr. Eades at Low Carb Breckenridge, Agatston score. [00:54:38] The Fat Emperor. [00:54:53] Low-carb Breckenridge 2018. [00:55:10] Ketofest, Keto Con, Low-carb USA, Refind Health. [00:55:45] Widowmaker movie.

Vergleichende Untersuchung von arteriellen versus venösen grafts als Bypassgefäße am Herzen anhand angiographischer Daten in mittel-langfristigen postoperativen Verlauf. Von insgesamt 2099 untersuchten Bypasses waren 819 der A. thor. int, 1280 der V. saphena magna.Die Venenbypasses zeigten eine Verschlußrate von 14%, die Arterien von 7,4% (p=0,0001).Die signifikanten Ergebnisse zur Bedeutung des Zielgefäßes unterstützten die routinemäßig angewandte Technik, beide arteriellen grafts mit einem großlumigen linkskoronaren Gefäß zu verbinden. Die Risikofaktorenanalyse hob Hyperlipidämie als unabhängigen Risikofaktor für Bypassverschluß hervor, Nikotinabusus konnte nicht in die Untersuchungen aufgenommen werden.Die Arbeit zeigt anhand der überlegenen Offenheitsraten der A.-thoracia int. -Bypasses, dass Patienten auch mittel-langfristig von der Verwendung beider arteriellen Gefäße profitiern

Im Rahmen dieser Dissertation wurde der potentielle Einfluss des endothelialen hyperpolarisierenden Faktors (EDHF) auf Thrombozyten untersucht und geprüft, ob die EDHF Wirkungen durch eine (oder mehrere) Epoxyeicosatriensäuren (Produkte der endothelialen CYP450 Monooxygenase) ausgelöst sein könnten. EDHF wurde bisher hauptsächlich, neben NO und Prostazyklin, als dritter funktionell bedeutender vom Endothel gebildeter vasodilatierender Faktor charakterisiert. Für NO und Prostazyklin ist vielfach eine Freisetzung in das Gefäßlumen und damit neben der lokalen dilatierenden Wirkung auch eine Beeinflussung zirkulierender Blutbestandteile, wie Thrombozyten beschrieben. Beide können die thrombozytäre Aktivierung und Aggregation effektiv hemmen und dadurch gefäßprotektive Wirkungen ausüben. Ob EDHF ebenfalls Blutbestandteile wie Thrombozyten beein-flussen kann, war die Hauptfragestellung dieser Arbeit. Wir konnten erstmals im Bioassay zeigen, dass kultivierte menschliche Endothelzellen (HUVEC) nach entsprechender Stimulation einen EDHF freisetzen, der Thrombozyten hyperpolarisiert. Weiterhin konnten wir nachweisen, dass dieser Faktor die thrombozytäre Adhäsion an Endothelzellen sowie die thrombozytäre Aktivierung (P-Selektin Expression) hemmte. Diese Effekte waren - analog zu den hyper-polarisierenden Effekten - vermittelt durch Aktivierung von Calcium aktivierbaren Kalium-Kanälen (KCa-Kanäle) mit großer (BKCa) und mittlerer (IKCa) Leitfähigkeit, nicht jedoch von denen mit geringerer (SKCa) Leitfähigkeit. Die beobachteten Hemmeffekte waren durch die EDHF Wirkungen auf das thrombozytäre Membranpotential erklärbar, ein zusätzlicher ergänzender membranpotentialunabhängiger Effekt konnte jedoch nicht ausgeschlossen werden. Der in unserem Bioassay nachweisbare EDHF zeigte ähnliche Eigenschaften wie exogen verabreichte Epoxyeicosatriensäuren (EETs) - Produkte, die durch die Cytochrom P450 2C8/9 Oxidase im Endothel aus Arachidonsäure gebildet werden. Erhärtet wurden diese Befunde durch eine CYP2C9 stabil überexprimierende Zellinie mit endothelialen Eigenschaften, welche verschiedene EETs in physiologischen Konzen-trationen freisetzte und deren Überstand ähnliche hyperpolarisierende und antiadhäsive Effekte auf Thrombozyten wie der EDHF hatte. EDHF stellte somit unter unseren experimentellen Bedingungen eine Epoxyeicosa-triensäure (oder eine Mischung verschiedener EETs) dar. Bei vielen Herz-Kreislauf Erkrankungen spielen thrombozytäre Aktivierung und Adhäsion eine wichtige Rolle. Insbesondere beim akuten Herzinfarkt, der Haupttodesursache in westlichen Industrieländern, kommt es in patho-physiologisch, z.B. durch Atherosklerose, vorgeschädigten Gefäßen, aufgrund einer arteriellen Thrombusbildung zum kompletten Gefäß-verschluss mit Myokardischämie. Daher könnte EDHF bzw. EET - infolge seiner thrombozytenhyperpolarisierenden und antiadhäsiven Effekte - von großer Bedeutung sein, vor allem, wenn er durch Risikofaktoren wie freie Sauerstoffradikale und Hyperlipidämie weniger stark beeinflusst würde als NO. Die Daten dieser Dissertation könnten somit zukünftiger Ansatzpunkt für weitere Untersuchungen sowie Basis für die Entwicklung potentiell gefäßprotektiver Medikamente zur effektiveren Therapie kardiovaskulärer Erkrankungen darstellen.

Einleitung: Im Klinikum Innenstadt der Ludwig-Maximilians-Universität München werden herztransplantierte Patienten im Rahmen der nachsorglichen Betreuung in regelmäßigen Abständen sonographisch untersucht. Ziel dieser Arbeit ist es, bei einem dort regelmäßig betreuten Patientengut Infektionen, Neoplasien und andere unerwünschte Wirkungen der Immunsuppression wie vor allem die anhand der routinemäßigen Abdominalsonographien erhobenen pathologischen Befunde und morphologischen Organveränderungen deskriptiv zu dokumentieren. Dadurch soll ein Eindruck von der klinischen Relevanz der routinemäßigen Abdominalsonographie als Screening-Methode in der Nachsorge bei herztransplantierten Patienten zur frühzeitigen Erfassung pathologischer Befunde infolge immunsuppressiver Medikation geschaffen werden. Methode: Das Patientengut der vorliegenden Studie bestand ausschließlich aus herztransplantierten Patienten, die zur Vermeidung einer Transplantatabstoßung eine immunsuppressive Medikation erhielten und zwar als Kombination aus den immunsuppressiven Substanzen Cyclosporin A oder Tacrolimus, Azathioprin, Mycophenolat mofetil und Prednisolon. Insgesamt handelte es sich um 122 Patienten, die im Zeitraum von 1983 bis 1999 ein Spenderherz erhalten haben und von denen 85 Cyclosporin und 37 Tacrolimus als Basisimmunsuppressivum bekamen. Dazu wurden die pathologischen Befunde des Gesamtkollektivs ein Jahr, drei Jahre und fünf Jahre nach Herztransplantation des jeweiligen Patienten graphisch dargestellt. Zusätzlich zu den pathologisch-morphologischen sonographischen Befunden sollten auch die Häufigkeitsverteilungen der Neoplasien, opportunistischen Infektionen, das Neuauftreten von Diabetes mellitus, arterieller Hypertonie, Hyperlipidämie, Hyperurikämie, koronarer Herzkrankheit, peripherer arterieller Verschlusskrankheit sowie das Auftreten einer transitorischen ischämischen Attacke nach Herztransplantation dokumentiert werden. Abgesehen von den Häufigkeitsverteilungen im Gesamtkollektiv sollten auch die Häufigkeitsverteilungen in der Cyclosporin-Gruppe und der Tacrolimus-Gruppe angegeben werden. Von einem Vergleich dieser beiden Gruppen mit Signifikanzberechnungen sollte jedoch aufgrund mannigfaltiger Einflussgrößen abgesehen werden. Ergebnisse: Fünf Jahre nach Transplantation ergaben sich im Gesamtkollektiv unter anderem folgende Befunde: • 38,5 % Cholelithiasis • 9,0 % Cholezystitis • 21,3 % Hepatomegalie • 51,6 % Echogenitätserhöhung der Leber (Fettleber) • 36,1 % Größenabnahmen der Nieren • 86,9 % Echogenitätserhöhung der Nieren • 76,2 % Verminderung der Parenchymbreite der Nieren • 77,0 % Niereninsuffizienz im Stadium der kompensierten Retention • 9,8 % Niereninsuffizienz im präterminalen bzw. terminalen Stadium • 17,2 % sekundärer Hyperparathyreoidismus • 27,0 % Osteoporose • 19,7 % Pankreaslipomatose • 23,8 % Splenomegalie • 38,5 % Aortensklerose • 27,0 % maligne Entartungen • 52,5 % opportunistische Infektionen • 70,5 % Neuauftreten von arterieller Hypertonie • 65,6 % Neuauftreten von Hyperlipidämie • 16,4 % Neuauftreten der koronaren Herzkrankheit (KHK) • 18,0 % Neuauftreten der peripheren arteriellen Verschlusskrankheit (pAVK) • 5,7 % Erstmanifestation einer transitorischen ischämischen Attacke (TIA) Schlussfolgerung: In Anbetracht der Häufigkeit der anhand serieller Sonographien frühzeitig erfassbaren pathologisch-morphologischen Veränderungen der Abdominalorgane ist zu schließen, dass die in regelmäßigen zeitlichen Intervallen durchgeführte Sonographie, eine kostengünstige und nicht-invasive Untersuchung, fester Bestandteil der nachsorglichen Betreuung (herz-) transplantierter Patienten sein sollte. Die möglichst frühzeitige Detektion pathologisch-morphologischer Veränderungen der Abdominalorgane ermöglicht dem behandelnden Arzt, rasch entsprechende Maßnahmen zu ergreifen, um eine weitere Verschlechterung der krankhaften Befunde zu verhindern bzw. wenigstens zu verzögern. So kann beispielsweise nach sonographischer Erfassung einer pathologisch verringerten Parenchymbreite der Nieren, die mit der Nephrotoxizität des verabreichten Calcineurin-Inhibitors Cyclosporin oder Tacrolimus im Zusammenhang stehen kann, das nicht nephrotoxische Mycophenolat mofetil (eventuell im Austausch gegen Azathioprin) in die immunsuppressive Kombinationstherapie integriert werden, was eine schrittweise Reduzierung der Erhaltungsdosis des nephrotoxischen Calcineurin-Inhibitors ermöglicht.