Podcasts about 3arid 3acrossref

This week we are discussing the new secondary analysis of the KANON study from this year...Do conservatively managed ACL's that show healing actually get better outcomes long term?https://journals.sagepub.com/doi/full/10.1177/03635465251339061?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Are your cells running low on energy? Fatigue, brain fog, and premature aging often trace back to one root issue: poor mitochondrial function. These tiny power plants inside your cells are responsible for producing the energy your body needs to thrive—and when they're weak, everything suffers. In this episode, Dr. Axe shares the top 10 ways to improve mitochondrial health so you can boost energy, sharpen focus, and slow the aging process—naturally. In this episode, you'll learn: Why mitochondria are essential for energy, brain health, and longevity Signs of mitochondrial dysfunction and how to spot them early The best foods, supplements, and peptides to support mitochondrial repair Top lifestyle therapies that enhance ATP production How toxins, stress, and poor sleep damage your mitochondria—and how to fix it If you're tired of feeling tired, this episode will help you recharge at the cellular level. #cellularhealth #mitochondria #naturalhealth #draxe ------  Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Twitter Facebook TikTok Website ------  Staying healthy in today's world is an upstream battle. Subscribe to Wellness Weekly, your 5-minute dose of sound health advice to help you grow physically, mentally, and spiritually. Every Wednesday, you'll get:  Holistic health news & life-hacks from a biblical world view Powerful free resources including classes, Q&As, and guides from Dr. Axe The latest episodes of The Dr. Josh Axe Show Submit your questions via voice memo to be featured on the show → speakpipe.com/drjoshaxe  ------  Links:  https://pmc.ncbi.nlm.nih.gov/articles/PMC10779395/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7392668/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10541842/ https://pubmed.ncbi.nlm.nih.gov/18708297/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11273532/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9729331/ https://www.sciencedirect.com/science/article/pii/S0531556523000864?via%3Dihub https://pubmed.ncbi.nlm.nih.gov/36091835/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/ https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/ https://pubmed.ncbi.nlm.nih.gov/32776825/ https://pubmed.ncbi.nlm.nih.gov/32554501/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8504390/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8793015/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5407969/ https://journals.physiology.org/doi/full/10.1152/physiol.00038.2018?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org https://pmc.ncbi.nlm.nih.gov/articles/PMC5423095/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11377238/ https://pubmed.ncbi.nlm.nih.gov/34944468/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9518606/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10989710/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5483482/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10380951/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11139944/ https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/nyas.12998 https://pmc.ncbi.nlm.nih.gov/articles/PMC9601556/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10057714/  ------  Ads:  Even if your bloodwork looks "normal," your symptoms could point to Cell Danger Response (CDR). Discover how to break free from CDR and unlock your full potential at https://beyondbloodwork.com/. 

In this groundbreaking episode of the Dr. Josh Axe Show, we dive deep into the fascinating world of colloidal silver - a natural mineral supplement with extraordinary antimicrobial properties that could revolutionize how we fight infections. Key Takeaways:  Discover how silver ions can penetrate and destroy harmful bacteria at the cellular level Learn about silver's historical medical uses, from wound care to surgical applications Uncover the scientific mechanisms behind colloidal silver's powerful antimicrobial effects Explore cutting-edge research on silver's potential to combat antibiotic-resistant bacteria Tips on safe dosage and application for different health conditions Tune in to unlock nature's hidden antimicrobial secret! You'll walk away with a comprehensive understanding of how this ancient mineral can support your immune system, fight infections, and potentially offer a natural alternative to traditional antibiotics. Whether you're a health enthusiast, looking for holistic wellness strategies, or simply curious about natural healing, this episode is your ultimate guide to harnessing the power of colloidal silver. #naturalhealing #colloidalsilver #alternativemedicine Want more of The Dr. Josh Axe Show? Subscribe to the YouTube channel. Follow Dr. Josh Axe Instagram Twitter Facebook TikTok Website ------  Staying healthy in today's world is an upstream battle. Subscribe to Wellness Weekly, your 5-minute dose of sound health advice to help you grow physically, mentally, and spiritually. Every Wednesday, you'll get: Holistic health news & life-hacks from a biblical world view Powerful free resources including classes, Q&As, and guides from Dr. Axe The latest episodes of The Dr. Josh Axe Show Submit your questions via voice memo to be featured on the show → speakpipe.com/drjoshaxe  ------  Links:  https://karger.com/books/book/2547/chapter-abstract/5742863/Silver-in-Health-Care-Antimicrobial-Effects-and?redirectedFrom=fulltext https://pmc.ncbi.nlm.nih.gov/articles/PMC6315945/ https://pubmed.ncbi.nlm.nih.gov/31963769/ https://www.liebertpub.com/doi/10.1089/acm.2011.0681?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed https://www.nature.com/articles/s41598-023-36460-2 https://pmc.ncbi.nlm.nih.gov/articles/PMC10393856/ https://www.nccih.nih.gov/health/colloidal-silver-what-you-need-to-know https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/colloidal-silver/faq-20058061  ------  Ads:  Even if your bloodwork looks "normal," your symptoms could point to Cell Danger Response (CDR). Discover how to break free from CDR and unlock your full potential at https://beyondbloodwork.com. Visit https://www.soltechealth.com to learn more and save $100 off your purchase using the code AXE. Experience the difference for yourself with a 60-day risk free trial. Soltec Health—Rest, Recover, Rejuvenate. Visit silverbiotics.com to check out my favorite colloidal silver product on the market. Make sure to use code AXE at checkout for 30% off your first purchase!

View Part 1 here: https://youtube.com/live/VCJdne9xgqgDr. Sabine Hazan returns to the Zone to discuss various aspects of the microbiome and its impact on health. During her conversation with Dr. Osborne, they explore topics such as fecal transplants, inflammatory bowel disease, and the differences in microbiomes between individuals.They also discuss the effects of cesarean section versus vaginal birth on the newborn's microbiome and the potential implications of imbalances in the overall microbiome of the planet. The conversation highlights the need for more research and funding in the field of microbiome studies. They discuss the potential benefits of fecal transplants for various conditions, including inflammatory bowel disease and autism.Some of Dr. Hazan's work discussed in this interview is posted below:Vitamin C improves gut Bifidobacteria in humans https://www.futuremedicine.com/doi/full/10.2217/fmb-2022-0209?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgDetection of SARS-CoV-2 from patient fecal samples by whole genome sequencing https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846909/Microbiome-Based Hypothesis on Ivermectin's Mechanism in COVID-19: Ivermectin Feeds Bifidobacteria to Boost Immunity. https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-1963494Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity. https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-1816751Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826831/To connect with Dr. Osborne visit:On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/Pinterest: https://www.pinterest.com/docosborne/Instagram: https://www.instagram.com/drosborneTwitter: https://twitter.com/glutenology*These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Peter Osborne is one of the most sought after alternative and nutritional experts in the world. A Diplomate with the American Clinical Board of Nutrition, a graduate of Texas Chiropractic College, and a doctor of pastoral science, Dr. Osborne is one of the world's leading authorities on gluten, nutrition, and natural health. He is the founder GlutenFreeSociety.org, one of the world's largest informational sites on gluten sensitivity. In addition, he is the author of the best selling book, No Grain No Pain, published by Touchstone (Simon & Schuster). His work has been featured by PBS, Netflix, Amazon, Fox, and many other nationally recognized outlets. For more information, visit us at https://www.glutenfreesociety.org/ or call 281-903-7527

Intermittent fasting Podcast: https://open.spotify.com/episode/69vmHEA5IGiEyAtaAI4HG8?si=fcff8cf93c154d7b  Afvallen zit tussen je oren deel 1: https://open.spotify.com/episode/3GjOlosC5dZuFDBIwdZYPO?si=61d364122b3549c1 Bronnen:https://journals.physiology.org/doi/full/10.1152/ajpendo.00156.2017?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org https://www.hsph.harvard.edu/news/press-releases/diets-weight-loss-carbohydrate-protein-fat/ http://nwcr.ws/Research/default.htmStuur ons een DM op Instagram met jouw fitnessvragen voor de podcast: https://www.instagram.com/project_ijzersterk/Wil jij dat wij jou helpen om te transformeren in 12 weken? Meld je aan voor een vrijblijvende kennismaking: www.projectijzersterk.nl We bespreken in deze podcast: 0:00 Afvaltips van Joel Beukers?1:00 Grote valkuil met informatie van internet.4:30 De caloriebalans werkt niet?7:55 Hormonen ipv calorieën?25:15 Veel eetmomenten om aan te komen?27:00 Insuline belangrijker dan calorieën?28:30 Invloed van marketing op eetgedrag?39:50 Caloriebalans alléén is niet genoeg?43:30 Het voordeel van het hebben van een plan.  47:10 Gezondheid is het fundament van alles!51:15 De maatschappij maakt het je moeilijk om gezond te zijn!

Welcome back to Working Weights LLC, where we delve deep into the science and practicality of fitness and wellness. In this episode, Coach Lamby and co-host Dwayne tackle a fascinating topic: the disparity between brown fat and white fat, and how understanding this difference can impact your fitness journey.Brown fat, often dubbed as the "good fat," and white fat, its counterpart, have garnered attention for their distinct roles in metabolism and thermogenesis. But what exactly sets them apart? Coach Lamby and Dwayne break down the physiological differences between these two types of adipose tissue and their implications for weight management.Furthermore, they explore the evidence surrounding methods to activate brown fat, particularly the debate over the effectiveness of cold plunges. Does subjecting yourself to icy temperatures truly stimulate brown fat activation? And if so, how significant are the potential benefits for fat loss and achieving that coveted shredded physique?Drawing upon scientific research and practical experience, Coach Lamby and Dwayne delve into the nuances of brown fat activation strategies, weighing the pros and cons of cold exposure techniques. They offer insights into integrating these methods into your fitness routine and discuss their potential synergies with other weight loss approaches.So, if you're curious about the science behind fat metabolism, the efficacy of cold plunges, and how understanding brown fat could revolutionize your fitness journey, tune in to this episode of Working Weights LLC. Get ready to elevate your knowledge and optimize your path to achieving your fitness goals!https://youtu.be/7UonfOoIl18https://journals.physiology.org/doi/full/10.1152/physrev.00015.2003?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orghttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988785/https://pubmed.ncbi.nlm.nih.gov/28099124/https://www.nejm.org/doi/10.1056/NEJMoa0808718?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.govhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627770/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536824/https://sportrxiv.org/index.php/server/preprint/view/301/603

This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose. 00:00:00 Podcast begins 00:04:00 Mike's background 00:05:15 Diving into fructose 00:13:00 Thoughts on honey and other carb sources 00:27:30 Robert Lustig rebuttal: is fructose addictive? 00:37:40 Fructose & fiber 00:47:00 How fructose affects the mitochondria 00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia 00:56:17 Is insulin the bad guy? 01:12:20 How insulin relates to diabetes, obesity, and insulin resistance 01:23:30 Balancing protein, fat and carbohydrates 01:30:00 Is fructose making us fat? 01:46:00 Final thoughts Connect with Mike: Mikefave.com https://m.youtube.com/@MikeFaveSimplified References: Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/ A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/ The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/ Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/ Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/ Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/ Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/ Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/ Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/ Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/ Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

Nothing discussed in this podcast is EVER medical advice, consult your physician for medical needs. Recent article summarizing Dr. Bryan's reserach: https://www.colorado.edu/today/2024/01/03/study-cannabis-can-make-workouts-more-fun-its-no-performance-enhancer Dr. Bryans research papers: https://www.liebertpub.com/doi/10.1089/can.2022.0338?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed   Please note... additional research is available behind paywalls but can be found and downloaded on the Bioactive Patreon page   Patreon www.patreon.com/cannabichem MAD LOVE MY FRIENDS

What is VO2max? Is Garmin VO2Max accurate? How much is genetic vs trainable? What contributes to running performance? Dave and Matt discuss vo2 Max and it's importance in running. Show Notes: Article on Genes and Trainability of VO2max -  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688475/  Article on Breaking 2 Project Physiology -  https://journals.physiology.org/doi/full/10.1152/japplphysiol.00647.2020?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org  Article on What it Would take to Break a 2hr marathon -  https://journals.physiology.org/doi/full/10.1152/japplphysiol.00563.2010?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org  Article on Marathon Physiology -  https://www.frontiersin.org/articles/10.3389/fcvm.2022.856875/full#B1 

Are you ready for a lil chat about season depression? A li'l seasonal depresh?    Highlights in this episode:  • What is seasonal depression or Seasonal Affective Disorder (S.A.D.)? • About Dr. Norman Rosenthal, the scientist to give this a name • Contributing factors  • Why only certain people get seasonal depression and which factors make it worse • How to cope with mindset and feelings • How to cope with supplements • How to be supportive of friends who experience seasonal depression • The benefits of natural light and artificial "happy lights"   Part 2 is all about the role of vitamin D. There are some surprising factors and fixing seasonal depression is NOT as simple as "just take some vitamin D". That's why it's getting its own episode.    Resources in this episode:  https://www.normanrosenthal.com  https://www.psychiatria-danubina.com/UserDocsImages/pdf/dnb_vol28_no1/dnb_vol28_no1_25.pdf  https://www.psychiatry.org/patients-families/seasonal-affective-disorder  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673349/  https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.162.4.656?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&    Happy lights recommended by Dr. Rosenthal: https://verilux.com/   https://carex.com/     Red light therapy panels: https://joovv.com/ https://redtherapy.co http://www.clearlightventures.com/ https://bioslighting.com/ https://www.biolight.shop/ https://mitoredlight.com  https://omniluxled.com    FitFizz website:  https://fitfizzstudio.com 

This week we discuss a variety of scientific and preliminary research articles, with a critical perspective on what can be taken from the research and we identify and discuss how the research was conducted. joint smoking research article: https://www.liebertpub.com/doi/10.1089/can.2023.0123?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub+@UCulZrajYO2EnlbfufWU1DnQ john hopkins smoking vs vaping thc uptake in blood: https://www.hopkinsmedicine.org/news/newsroom/news-releases/2018/12/vaping-cannabis-produces-stronger-effects-than-smoking-cannabis-for-infrequent-users side lighting article: https://www.cannabisbusinesstimes.com/news/intercanopy-lighting-research-cannabis/?fbclid=PAAaZi_hBwWyfitOTlnMmiDug2sxAobJ7aYhUgxwB3HC8xS2pveOjl-YGu-0g mycorrhizal fungi article swiss farms: https://www.nature.com/articles/s41564-023-01520-w giberrilins and trichome formation article from very end of the show: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34957/ This week host @Jackgreenstalk (aka @Jack_Greenstalk on X/instagram backup account) [or contact via email: JackGreenstalk47@gmail.com] is joined by the always amazing panel with @spartangrown on instagram only or email spartangrown@gmail.com for contacting spartan outside social media, any alternate profiles on other social medias using spartan's name, and photos are not actually spartan grown be aware, @drmjcoco from cocoforcannabis.com as well as youtube where he tests and reviews grow lights and has grow tutorials and @drmjcoco on instagram and Matthew Gates aka @SynchAngel on instagram and twitter and @Zenthanol on youtube who offers IPM direct chat for $1 a month on patreon.com/zenthanol ... This week we missed @TheAmericanOne on youtube aka @theamericanone_with_achenes on instagram who's amy aces can be found at amyaces.com, and @Rust.Brandon of @Bokashi Earthworks who's products can be found at bokashiearthworks.com , @NoahtheeGrowa on instagram and @ATG Acres Aaron The Grower aka @atgacres his products can be found at atgacres.com and now has product commercially available in select locations in OK, view his instagram to find out details about drops! --- Support this podcast: https://podcasters.spotify.com/pod/show/cheaphomegrow/support

Bron 1: https://journals.physiology.org/doi/full/10.1152/ajpendo.00156.2017?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org  Bron 2: https://www.hsph.harvard.edu/news/press-releases/diets-weight-loss-carbohydrate-protein-fat/ Bron 3: http://nwcr.ws/Research/default.htmWil je dat we volgende keer jouw vraag behandelen, stuur ons dan een bericht op Instagram! @project_ijzersterkWil jij dat wij jou helpen om te transformeren in 12 weken? Meld je aan voor een vrijblijvende kennismaking: www.projectijzersterk.nl We bespreken in deze podcast: 0:00 Leugens over de caloriebalans?!1:08 Zijn alle calorieën hetzelfde?2:55 Hebben hormonen invloed op de caloriebalans?3:50 Is calorieën bijhouden té simpel?6:44 100 jaar oude studies?!9:15 Verbrand je minder als je minder eet?13:40 Studies die het tegendeel bewijzen!17:00 Het gevaar van dit soort video's.18:10 Waarom ik dit doe!

Jessica (jessicaoutofthecloset) joins us this week to talk about Dr Maria Montessori and her groundbreaking method for education... More from Jessica Get your tickets for Sci Guys Live in London here! Grab yourself some merch! You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading Jessica's Montessori Video https://www.youtube.com/watch?v=rX_TVG1DZuc Maria Montessori https://link.springer.com/article/10.1007/s00247-019-04560-9 https://www.newyorker.com/books/under-review/the-miseducation-of-maria-montessori Montessori Studies https://www.bbc.com/future/article/20230131-does-the-montessori-method-actually-work https://pubmed.ncbi.nlm.nih.gov/34899465/ https://www.forbes.com/sites/traversmark/2021/12/28/new-research-highlights-the-long-term-benefits-of-a-montessori-education/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10406168/ Gentle Parenting https://www.independent.co.uk/life-style/health-and-families/feet-tiktok-york-research-itv-b2227851.html https://www.forbes.com/health/family/what-is-gentle-parenting/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123053/ https://econtent.hogrefe.com/doi/full/10.1024/1422-4917/a000853?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org https://academic.oup.com/pnasnexus/article/2/6/pgad145/7192947

In this Re-Release of Episode 7 on 4/12/23 of the School of Doza podcast, Nurse Doza provides natural energy solutions to listeners. Nurse Doza gives advice on how to boost energy, where to find it, why fatigue might be occurring, and how to better maintain energy. Additionally, she emphasizes the importance of adrenal gland health to achieving genuine energy and provides instructions on how to support these glands.     00:00 Class is in session 04:09 Support adrenal glands for energy. 05:49 Support adrenal glands with B5. 12:30 Boost dopamine production naturally. 17:17 Support dopamine production daily. 24:19 Increase ATP production for energy. 32:00 Boost energy naturally with cold. 34:15 Support your metabolism naturally.   CHECK OUT MSW NUTRITION SUPPLEMENTS USE CODE NURSEDOZA FOR A NICE DISCOUNT https://www.mswnutrition.com/products/?ref=NURSEDOZA   CLASS NOTES:   First way to boost your energy is __support your adrenal glands_______________. Why? They are a hormone factory and their production decreases with age and stress.   The adrenal glands make stress hormones for us to function. “Salt, sugar, sex” (1) Cortisol, dopamine, norepinephrine, aldosterone (1st layer), sex hormones DHEA-most abundant hormone in the body (1) precursor: progesterone, estrogen, cortisol, and testosterone , pregnenolone,    “The adrenal glands play a vital role in the body's fight or flight response. They generate stress hormones that activate physiological adaptations that are necessary to counteract changes in the external environment. (1) Vitamin b5 “Vitamin B5 (VB5), also known as pantothenate or "anti-stress vitamin,"” (2) “Its deficiency leads to reduced cortisol production, increased arthritic pain, myalgia, fatigue, headache, depression, insomnia, and widespread "proinflammatory" effects on the immune-system.” Studies: Anatomy, Abdomen and Pelvis: Adrenal Glands (Suprarenal Glands) https://www.ncbi.nlm.nih.gov/books/NBK482264/ (1) The potential role of B5: A stitch in time and switch in cytokine https://pubmed.ncbi.nlm.nih.gov/31691401/ (2) Second way to boost your energy is __support your dopamine production_______________. Dopamine functions: (1) Memory. Pleasurable reward and motivation. Behavior and cognition. Attention. Sleep and arousal. Mood. Learning. Lactation. Dopamine also: (1) Causes blood vessels to relax (at low doses, it acts as a vasodilator) or constrict (at high doses, it acts as a vasoconstrictor). Increases sodium (salt) and urine removal from your body. Reduces insulin production in your pancreas. Slows gastrointestinal (GI) (gut) content movement and protects your GI lining. Reduces lymphocyte activity in your immune system.   “If you have the right balance of dopamine, you feel: (1) Happy.***** Motivated. Alert.*** Focused.***** If you have a low dopamine level, you might feel: (1) Tired. Unmotivated. Unhappy. You may also have: Memory loss. Mood swings. Sleep problems. Concentration problems. A low sex drive. “Dopamine is known as the “feel-good” hormone. It gives you a sense of pleasure. It also gives you the motivation to do something when you're feeling pleasure.(1)” ***Is this the hormone we should target in depression?*** “Depression is common - one-fourth of the U.S. population will have a depressive episode sometime in life. “(2) **DOES LOW DOPAMINE SOUND LIKE DEPRESSION? “Folate is a water-soluble B-vitamin necessary for the proper biosynthesis of the monoamine neurotransmitters serotonin, epinephrine, and dopamine.” (2)   “Without the participation of 5-MTHF in this process, SAMe and neurotransmitter levels decrease in the cerebrospinal fluid, contributing to the disease process of depression. SAMe supplementation was shown to improve depressive symptoms.” (2) **BLISS** Studies: Dopamine: https://my.clevelandclinic.org/health/articles/22581-dopamine (1) The methylation, neurotransmitter, and antioxidant connections between folate and depression https://pubmed.ncbi.nlm.nih.gov/18950248/ (2) Third way to boost your energy is __regulate your insulin_______________. “If you have type 2 diabetes, your body does not use insulin properly. This is called insulin resistance.” “Diabetes is a problem with your body that causes blood sugar (also called blood glucose) levels to rise higher than normal. This is also called hyperglycemia.” (1) “Things that can make blood sugar rise include: A meal or snack with more food or more carbohydrates than usual Inactivity Side effects of medications Infection or other illness Changes in hormone levels, such as during menstrual periods Stress   Studies: Blood sugar and insulin at work: https://diabetes.org/tools-support/diabetes-prevention/high-blood-sugar (1)   3rd way to boost your energy is to increase your ATP production: “Adenosine triphosphate, also known as ATP, is a molecule that carries energy within cells. It is the main energy currency of the cell,”   “Mitochondria are subcellular self-autonomous organelles primarily responsible for the generation of energy and ATP synthesis. “ (2)   “with age, mitochondria accumulate ROS-induced damage and become dysfunctional. With time, the function of cells declines causing aging and subsequent death.” (2)   Studies: https://biologydictionary.net/atp/ (1) Mitochondrial Aging and Age-Related Dysfunction of Mitochondriahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003832/(2) Fourth way to boost your energy is _infrared light therapy________________. “this induces activation of signaling pathways that affect cellular metabolism.”(1) “Subsequent experiments demonstrated that isolated mitochondria are sensitive to irradiation with monochromatic light in the red and near-infrared spectrum. For example, illumination of isolated rat liver mitochondria increased adenosine triphosphate (ATP) synthesis and oxygen consumption.” (1) Studies:Low-level light therapy of the eye and brain  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436183/ (1) 5th way to boost your energy is __cold exposure__________________. “In healthy individuals, cold exposure can increase energy expenditure and whole body glucose and fatty acid utilization. Repeated exposures can lower fasting glucose and insulin levels and improve dietary fatty acid handling, even in healthy individuals.” (1) “discovery that human BAT could be stimulated to produce heat and clear circulating substrates upon cold exposure” (1)   “the stimulation of cutaneous cold-sensitive thermoreceptors results in the activation of autonomic and somatic motor responses to limit heat loss to the environment and increase metabolic heat production “ (1)   Studies: Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes https://journals.physiology.org/doi/full/10.1152/japplphysiol.00934.2020?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org (1)  

In this podcast, Nurse Doza provides tips for recovering from a night of drinking. He suggests taking a multivitamin, especially one with electrolytes and trace minerals, to help replenish the vital nutrients alcohol has depleted. He also recommends avoiding caffeine to help the hangover go away and encourages listeners to invest in their health by joining his webinar   TIMESTAMPS: 00:00 Start 02:13 Replenish vital nutrients after drinking. 05:20 Replenish liver with key nutrients. 11:19 Take liver detox supplements. 19:40 Get restful sleep for recovery. 20:18 Prepare for healthy sleep. 25:45 Pre-tox before drinking.    SHOP MSW & LIVER LOVE HERE https://www.mswnutrition.com/discount/NURSEDOZA?ref=NURSEDOZA   REFERENCES: Studies: https://www.ncbi.nlm.nih.gov/books/NBK548710/(1) https://www.journal-of-hepatology.eu/article/S0168-8278(22)02932-4/fulltext(2)  https://www.sciencedaily.com/releases/2022/08/220805091251.htm(3)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861788/(4)  https://www.jle.com/fr/revues/mrh/e-docs/magnesium_homeostasis_and_alcohol_consumption_279741/article.phtml(5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400835/(6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490252/(7)  https://journals.physiology.org/doi/full/10.1152/jappl.1997.83.4.1152?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org(8)  https://www.pnas.org/doi/10.1073/pnas.112336399(9)   https://www.ncbi.nlm.nih.gov/books/NBK548710/(1) https://pubmed.ncbi.nlm.nih.gov/1452945/(2)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470839/(3)  https://pubmed.ncbi.nlm.nih.gov/11368579/(4)  https://pubmed.ncbi.nlm.nih.gov/30019966/(1)  https://pubmed.ncbi.nlm.nih.gov/32808029/(2)  https://www.nature.com/articles/s41598-021-92676-0 (3)  https://pubmed.ncbi.nlm.nih.gov/27603810/(4)  https://www.nature.com/articles/srep29743(5)  https://www.mountsinai.org/health-library/supplement/betaine(6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266414/(7)  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150440(8)  https://pubmed.ncbi.nlm.nih.gov/23232418/(9)  https://www.pnas.org/doi/10.1073/pnas.112336399(10)  https://www.sleepfoundation.org/nutrition/alcohol-and-sleep (1) https://pubmed.ncbi.nlm.nih.gov/10840864/ (2)  https://pubmed.ncbi.nlm.nih.gov/23051584/(3) https://www.sciencedirect.com/science/article/pii/S0013935118300355(4)   https://pubmed.ncbi.nlm.nih.gov/32419511/(5)  https://pubmed.ncbi.nlm.nih.gov/33106037/(6)

This episode of the School of Doza podcast provides natural energy solutions to listeners. Nurse Doza gives advice on how to boost energy, where to find it, why fatigue might be occurring, and how to better maintain energy. Additionally, she emphasizes the importance of adrenal gland health to achieving genuine energy and provides instructions on how to support these glands.     00:00 Class is in session 04:09 Support adrenal glands for energy. 05:49 Support adrenal glands with B5. 12:30 Boost dopamine production naturally. 17:17 Support dopamine production daily. 24:19 Increase ATP production for energy. 32:00 Boost energy naturally with cold. 34:15 Support your metabolism naturally.   CHECK OUT MSW NUTRITION SUPPLEMENTS USE CODE NURSEDOZA FOR A NICE DISCOUNT https://www.mswnutrition.com/products/?ref=NURSEDOZA   CLASS NOTES:   First way to boost your energy is __support your adrenal glands_______________. Why? They are a hormone factory and their production decreases with age and stress.   The adrenal glands make stress hormones for us to function. “Salt, sugar, sex” (1) Cortisol, dopamine, norepinephrine, aldosterone (1st layer), sex hormones DHEA-most abundant hormone in the body (1) precursor: progesterone, estrogen, cortisol, and testosterone , pregnenolone,    “The adrenal glands play a vital role in the body's fight or flight response. They generate stress hormones that activate physiological adaptations that are necessary to counteract changes in the external environment. (1) Vitamin b5 “Vitamin B5 (VB5), also known as pantothenate or "anti-stress vitamin,"” (2) “Its deficiency leads to reduced cortisol production, increased arthritic pain, myalgia, fatigue, headache, depression, insomnia, and widespread "proinflammatory" effects on the immune-system.” Studies: Anatomy, Abdomen and Pelvis: Adrenal Glands (Suprarenal Glands) https://www.ncbi.nlm.nih.gov/books/NBK482264/ (1) The potential role of B5: A stitch in time and switch in cytokine https://pubmed.ncbi.nlm.nih.gov/31691401/ (2) Second way to boost your energy is __support your dopamine production_______________. Dopamine functions: (1) Memory. Pleasurable reward and motivation. Behavior and cognition. Attention. Sleep and arousal. Mood. Learning. Lactation. Dopamine also: (1) Causes blood vessels to relax (at low doses, it acts as a vasodilator) or constrict (at high doses, it acts as a vasoconstrictor). Increases sodium (salt) and urine removal from your body. Reduces insulin production in your pancreas. Slows gastrointestinal (GI) (gut) content movement and protects your GI lining. Reduces lymphocyte activity in your immune system.   “If you have the right balance of dopamine, you feel: (1) Happy.***** Motivated. Alert.*** Focused.***** If you have a low dopamine level, you might feel: (1) Tired. Unmotivated. Unhappy. You may also have: Memory loss. Mood swings. Sleep problems. Concentration problems. A low sex drive. “Dopamine is known as the “feel-good” hormone. It gives you a sense of pleasure. It also gives you the motivation to do something when you're feeling pleasure.(1)” ***Is this the hormone we should target in depression?*** “Depression is common - one-fourth of the U.S. population will have a depressive episode sometime in life. “(2) **DOES LOW DOPAMINE SOUND LIKE DEPRESSION? “Folate is a water-soluble B-vitamin necessary for the proper biosynthesis of the monoamine neurotransmitters serotonin, epinephrine, and dopamine.” (2)   “Without the participation of 5-MTHF in this process, SAMe and neurotransmitter levels decrease in the cerebrospinal fluid, contributing to the disease process of depression. SAMe supplementation was shown to improve depressive symptoms.” (2) **BLISS** Studies: Dopamine: https://my.clevelandclinic.org/health/articles/22581-dopamine (1) The methylation, neurotransmitter, and antioxidant connections between folate and depression https://pubmed.ncbi.nlm.nih.gov/18950248/ (2) Third way to boost your energy is __regulate your insulin_______________. “If you have type 2 diabetes, your body does not use insulin properly. This is called insulin resistance.” “Diabetes is a problem with your body that causes blood sugar (also called blood glucose) levels to rise higher than normal. This is also called hyperglycemia.” (1) “Things that can make blood sugar rise include: A meal or snack with more food or more carbohydrates than usual Inactivity Side effects of medications Infection or other illness Changes in hormone levels, such as during menstrual periods Stress   Studies: Blood sugar and insulin at work: https://diabetes.org/tools-support/diabetes-prevention/high-blood-sugar (1)   3rd way to boost your energy is to increase your ATP production: “Adenosine triphosphate, also known as ATP, is a molecule that carries energy within cells. It is the main energy currency of the cell,”   “Mitochondria are subcellular self-autonomous organelles primarily responsible for the generation of energy and ATP synthesis. “ (2)   “with age, mitochondria accumulate ROS-induced damage and become dysfunctional. With time, the function of cells declines causing aging and subsequent death.” (2)   Studies: https://biologydictionary.net/atp/ (1) Mitochondrial Aging and Age-Related Dysfunction of Mitochondriahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003832/(2) Fourth way to boost your energy is _infrared light therapy________________. “this induces activation of signaling pathways that affect cellular metabolism.”(1) “Subsequent experiments demonstrated that isolated mitochondria are sensitive to irradiation with monochromatic light in the red and near-infrared spectrum. For example, illumination of isolated rat liver mitochondria increased adenosine triphosphate (ATP) synthesis and oxygen consumption.” (1) Studies:Low-level light therapy of the eye and brain  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436183/ (1) 5th way to boost your energy is __cold exposure__________________. “In healthy individuals, cold exposure can increase energy expenditure and whole body glucose and fatty acid utilization. Repeated exposures can lower fasting glucose and insulin levels and improve dietary fatty acid handling, even in healthy individuals.” (1) “discovery that human BAT could be stimulated to produce heat and clear circulating substrates upon cold exposure” (1)   “the stimulation of cutaneous cold-sensitive thermoreceptors results in the activation of autonomic and somatic motor responses to limit heat loss to the environment and increase metabolic heat production “ (1)   Studies: Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes https://journals.physiology.org/doi/full/10.1152/japplphysiol.00934.2020?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org (1)

[CE contact hours--see below.] Improving quality of life for patients with heart failure can include lifestyle modifications and require successful behavior change strategies. Learn best practices to apply into your clinical setting from nurse providers Colleen McIlvennan, PhD, DNP, ANP, FAHA, FHFSA, of the University of Colorado in Denver, and Binu Koirala, PhD, MGS, RN, of the Johns Hopkins University School of Nursing in Baltimore.CE LINK: https://pcna.net/?p=10717&post_type=online-course&preview_id=10717PCNA Behavior Change mini-certifice (CE course): https://pcna.net/professional-development/online-learning/ "Behavior Change mini-certificate"AHA HF Tools & Resources: heart.org/en/health-topics/heart-failure/heart-failure-tools-resourcesAdherence to Healthy Sleep Patterns: ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.050792?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&Addressing Social Determinants of Health in Patients with HF: ahajournals.org/doi/10.1161/CIR.0000000000000767See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

References for chapter 8Robert Schrier proposed a unifying hypothesis to explain the sodium retention seen in edematous states like cirrhosis and heart failure, coining the term effective arterial blood volume (EABV). An open access review in JASN 2007 can be found here: https://jasn.asnjournals.org/content/18/7/2028#ref-3 John P PetersASN Annual Award: https://www.asn-online.org/about/awards/award.aspx?awh_key=0ea83199-f86d-4506-9507-d7e4ce688cb4Short article discussing contributions of Dr. Peters by mentees Dr. Franklin Epstein and Dr. Donald Seldin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588700/ and https://pubmed.ncbi.nlm.nih.gov/12097739/Epstein FH et al. Studies of the antidiuresis of quiet standing: the importance of changes in plasma volume and glomerular filtration. JCI 1950. In this classic report, investigators studied their own sodium excretion supine, standing and with a variety of maneuvers (saline or albumin infusion) and showed that urinary sodium excretion is limited in the upright position compared to supine position. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC436228/pdf/jcinvest00414-0077.pdfAn interesting review of early concepts on hypertension feature notes on John J Hay and Paul Dudley White. The former was known to say, “The greatest danger to a man with high blood pressure lies in its discovery because then some fool is certain to try and reduce it!” and the latter has been quoted as saying that hypertension might be compensatory but apparently, these quotes are out of context. To find out what they really said, check out: Elias MF and Goodell AL. Setting the record straight for two heroes in hypertension John J Hay and Paul Dudley White. J Clin Hypertens 2019 https://onlinelibrary.wiley.com/doi/epdf/10.1111/jch.13650 VA Cooperative Trial was an important study to establish the hypertension should, in fact, be treated The VA Cooperative Study and the Beginning of Routine Hypertension Screening, 1964-1980 This study was stopped after only 18 months because of an excess of deaths in the untreated group who had a mean diastolic BP of 115 mmHg. For a long time, only the diastolic BP was felt to be important until the Systolic Hypertension in Elderly Patients (“SHEP study”) clarified that treatment of isolated systolic hypertension is also importantPrevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic HypertensionWe continued to try to grapple with the work of Jens Titze on sodium which turns many of our assumptions about sodium upside down. His team studied astronauts on a long term high sodium diet and found an unexpected weekly (circaseptan) rhythm seemingly related inversely to aldosterone and directly with cortisol. His work also probes our notion of body sodium content. For a great first hand read, check out Dr TItze's review in Kidney International 2014 which he aptly dubs, “Spooky Sodium Balence.” https://www.sciencedirect.com/science/article/pii/S0085253815562807Epstein M. The cardiovascular and renal effects of head-out of water Immersion in Man. Circulation Research 1976 Cardiovascular and renal effects of head-out water immersion in man: application of the model in the assessment of volume homeosSpace flight is an exaggeration of the water immersion experiments. Astronauts on either a low or normal sodium diet had a reset of natriuetic peptides. A Salty Tale: Study Examines Sodium Regulation in Space and Natriuretic Peptide Resetting in Astronauts | CirculationBaroreceptors feature mechanically activated ion channels called PIEZO1 and PIEZO2. Zeng W, Marshall KL, Min S, Daou I, Chapleau MW, Abboud FM. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. Science 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102061/We also relearned an unfortunate truth: lots of folks pee in pools. De Laat et al. Water Res. 2011. Concentration levels of urea in swimming pool water and reactivity of chlorine with urea At the American College of Cardiology meeting in April, investigators shared the news that the combination of an ARB with new class of drugs called angiotensin receptor neprilysin inhibitor (ARNI) was not superior to ACE inhibitors at reduction of heart failure following acute MI. Here's the press release for the PARADISE-MI trial. Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial InfarctionA series of elegant experiments by Alicia McDonald's team to characterize pressure natriuresis. In these studies, they induce hypertension by constriction of the superior mesenteric artery, the celiac artery and the infrarenal aorta (essentially increasing afterload without directly altering the blood flow to the kidney). With this maneuver, the blood pressure of the experimental animal rises, urinary sodium excretion increases and then they demonstrate a shift in the Na-H ATPase from the apical membrane to intracellular vesicles in the proximal tubule and a shift in NCC from the luminal membrane to the intracellular vesicles in the distal tubules. Yang L et. al Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal 2002 https://journals.physiology.org/doi/full/10.1152/ajprenal.00298.2001?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgLee DH Riquier ADM, Yang LE, Leong PK, Maunsbach and McDonough AA. Acute hypertension provokes acute trafficking of distal tubule NaCl (NCC) to subapical cytoplasmic vesicles. Am J Physiol Renal Physiol. 2009 Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles This review in KI reports is also worth a read McDonough AA. Maintaining Balance under pressure-hypertension and the proximal tubule. 2015 ISN Forefronts Symposium 2015: Maintaining Balance Under Pressure—Hypertension and the Proximal Tubule

The discussion over what aspect of our diet has been driving the escalation of metabolic disease over the last 100 years has been a confusing one full of contradictory information. It would be logical to look for a change in our diet associated with such a dramatic change in the health of a population There are both correlated evidence and dietary trials to support the theory that the increase in linoleic acid, provided by the introduction of PUFA processed oils into our diet, is the driver. In this episode of Hunger Hunt Feast, I want to share a collection of them to help clarify some of the confusion. -- Episode Specific Links:  Linoleic acid concentrations in fats and oils http://www.distributionkatrina.com/english/comparison-of-dietary-fats.html Increase in Adipose Tissue Linoleic Acid of US Adults in the Last Half-Century https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4642429/ Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla https://www.sciencedirect.com/science/article/pii/S0022227520346733 Diets could prevent many diseases https://www.researchgate.net/publication/10673140_Diets_could_prevent_many_diseases Corn Oil in Treatment of Ischemic Heart Disease https://ncbi.nlm.nih.gov/pmc/articles/PMC2166702/ Linoleic acid causes greater weight gain than saturated fat without hypothalamic inflammation in the male mouse https://pubmed.ncbi.nlm.nih.gov/27886622/#:~:text=the%20male%20mouse-,Linoleic%20acid%20causes%20greater%20weight%20gain%20than%20saturated%20fat%20without,doi%3A%2010.1016%2Fj Effects of fatty acids on mitochondria: implications for cell death https://pubmed.ncbi.nlm.nih.gov/12206909/ Can linoleic acid contribute to coronary artery disease? https://pubmed.ncbi.nlm.nih.gov/8192728/ Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans https://pubmed.ncbi.nlm.nih.gov/8148354/ Acrolein is a product of lipid peroxidation reaction https://www.jbc.org/article/S0021-9258(18)80708-6/fulltext#seccestitle90 The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis https://pubmed.ncbi.nlm.nih.gov/16270280/ Rapeseed oil and sunflower oil diets enhance platelet in vitro aggregation and thromboxane production in healthy men when compared with milk fat or habitual diets https://pubmed.ncbi.nlm.nih.gov/1641826/ Stearoyl-CoA Desaturase-1 Is Associated with Insulin Resistance in Morbidly Obese Subjects https://link.springer.com/article/10.2119/molmed.2010.00078 Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909262/ Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909262/ Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/ “The Hateful Eight: Enemy Fats That Destroy Your Health - Dr. Cate.” Dr. Cate, 22 May 2020,  https://drcate.com/the-hateful-eight-enemy-fats-that-destroy-your-health/ Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6180905/ Strong increase in hydroxy fatty acids derived from linoleic acid in human low-density lipoproteins of atherosclerotic patients https://pubmed.ncbi.nlm.nih.gov/9488997/ Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA https://journals.physiology.org/doi/full/10.1152/ajpheart.00480.2004?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a) https://pubmed.ncbi.nlm.nih.gov/9844997/ “Dr. Knobbe Presents, ‘Macular Degeneration - Preventable & Treatable - With an Ancestral Diet?' at Weston A. Price Foundation's Annual Conference - Wise Traditions - 2017 - Cure AMD Foundation.” Cure AMD Foundation, https://www.cureamd.org/dr-knobbe-presents-macular-degeneration-preventable-treatable-with-an-ancestral-diet-at-weston-a-price-foundations-annual-conference-wise-traditions-2017/ Unsaturated fatty acids and their oxidation products stimulate CD36 expression in human macrophages https://www.researchgate.net/publication/11260045_Unsaturated_fatty_acids_and_their_oxidation_products_stimulate_CD36_expression_in_human_macrophages Lowering dietary linoleic acid (LA) reduces bioactive oxidized linoleic acid metabolites in humans https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3467319/ Can linoleic acid contribute to coronary artery disease? https://www.researchgate.net/publication/15005994_Can_linoleic_acid_contribute_to_coronary_artery_disease A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans https://pubmed.ncbi.nlm.nih.gov/9844997/ Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2012.38 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis https://www.bmj.com/content/346/bmj.e8707 Connect with Zane: ReLyte Electrolytes by Redmond Real Salt: https://shop.redmond.life?afmc=Zane Follow me on Instagram: https://www.instagram.com/zanegriggsfitness Follow me on YouTube: https://www.youtube.com/c/ZaneGriggs QUICK EPISODE SUMMARY What causes modern disease The hateful eight oils The correlation between vegetable oils and obesity The oxidation effects of LDL The truth about the dairy data How much cholesterol is in your brain  Where you can find a copy of today's mentioned study What we know about Linoleic acid

Do bisexual men exist? Noted bisexual, "Are They Gay" joins us this week as we cover the studies that claimed to prove that bisexual men were, in fact, a myth. AreTheyGay's channel: https://www.youtube.com/c/AreTheyGay Grab our merch now: http://normalcitizen.store You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! TikTok https://www.tiktok.com/@sciguys Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod Facebook http://facebook.com/SciGuysPod Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth References & Further Reading Arousal Pattern Studies & Articles https://www.nytimes.com/2005/07/05/health/straight-gay-or-lying-bisexuality-revisited.html https://journals.sagepub.com/doi/10.1111/j.1467-9280.2005.01578.x?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749350/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000017/ https://link.springer.com/article/10.1007/s10508-011-9881-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749278/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175819/ https://link.springer.com/article/10.1007/s10508-011-9746-0 https://www.pnas.org/doi/10.1073/pnas.2003631117 https://bi.org/en/questions/all-women-are-bisexual-but-bi-men-dont-exist-right eadt.co.uk/news/university-of-essex-research-on-bisexual-men-2685984 https://www.bbc.co.uk/news/health-34744903 Bisexuality & Kinsey Scale https://www.stonewall.org.uk/about-us/news/short-history-word-bisexuality https://bi.org/en/101/Kinsey-Klein https://kinseyinstitute.org/research/publications/kinsey-scale.php

Phil and Matt discuss a new impactful mini review paper from Stephan Van der Zwaard and colleagues on what adaptations endurance athletes should be chasing in the muscle fiber proper.Papers discussed:https://www.frontiersin.org/articles/10.3389/fspor.2021.719434/full#B134https://journals.physiology.org/doi/prev/20210513-aop/abs/10.1152/japplphysiol.00056.2021https://journals.physiology.org/doi/full/10.1152/japplphysiol.00946.2017?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Oxidative Potential Podcast LinksInstagram Links:https://www.instagram.com/criticalo2/?hl=enhttps://www.instagram.com/resiliencehpc/?hl=enYoutube Links:https://www.youtube.com/channel/UCfkBVklDMTPMbaPw0ikG2tgWebsite Links:https://www.resiliencehpc.ca/

In this episode we continue our discussion with Dr. Dajo Sanders (part 2 of 2), an individual whose skill and expertise in the realm of cycling performance are well developed. Dajo is a prolific researcher in many aspects of endurance training and specializes in the very distinct research cohort that is well-trained high-performance cyclists. He is also a member of the performance group at Team DSM where he uses his experience and knowledge to help World Tour cyclists perform at their absolute best.In this episode we discuss with Dajo his research and practice in monitoring training load in cyclists and also what cycling performance research he is excited about.Guest panelist:Dajo Sanders, PhDTwitter: @DajoSandersResearchgate: https://www.researchgate.net/profile/Dajo-Sanders-2LinkedIn: https://www.linkedin.com/in/dajo-sanders-ph-d-59112794/The podcast co-hosts:Jason Boynton, Ph.D.boyntoncoaching.comDamian Rusesemiprocycling.comCyrus Monkcyclistscientist.comInstagram: @cyclingperformanceclubFacebook: @cyclingperformanceclubTwitter: @cyclingclubpodLinkedIn: The Cycling Performance Club PodcastReferences:Methods of Monitoring Training Load and Their Relationships to Changes in Fitness and Performance in Competitive Road Cyclistshttps://journals.humankinetics.com/view/journals/ijspp/12/5/article-p668.xmlMaintaining Power Output with Accumulating Levels of Work Done Is a Key Determinant for Success in Professional Cyclinghttps://journals.lww.com/acsm-msse/Abstract/2021/09000/Maintaining_Power_Output_with_Accumulating_Levels.12.aspxHeat acclimation improves exercise performancehttps://journals.physiology.org/doi/full/10.1152/japplphysiol.00495.2010?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgHeat training increases exercise capacity in hot but not in temperate conditions: a mechanistic counter-balanced cross-over studyhttps://journals.physiology.org/doi/full/10.1152/ajpheart.00138.2015?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a recently described autoinflammatory syndrome characterized by diffuse inflammatory manifestations, predisposition to hematological malignancy, and an association with a high rate of thrombosis. VEXAS is attributed to somatic mutations in the UBA1 gene in hematopoietic stem and progenitor cells with myeloid restriction in mature forms. Join our conversation with Emma Groarke from the National Cancer Institute, USA, to understand how it was discovered and more. Article: https://www.nejm.org/doi/10.1056/NEJMoa2026834?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

We are back from the grave for this halloween episode. On the 2 year anniversary of Viral Load we dive into the wonderful world of monkeypox. Tune in to find out why you should care about this boil inducing disease. And whatever you do this hallows eve don't pet prairie dogs!sources:https://www.statnews.com/2021/07/20/more-than-200-people-in-u-s-being-monitored-for-possible-monkeypox-exposure-cdc-says/https://www.wsbtv.com/news/local/atlanta/1st-us-case-monkeypox-comes-traveler-flying-through-atlanta/BWBQZ5OIV5ANRP7MMOLJJMHF5U/https://www.cdc.gov/poxvirus/monkeypox/index.htmlhttps://www.sciencedirect.com/topics/neuroscience/monkeypoxhttps://pubmed.ncbi.nlm.nih.gov/22041995/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187089https://pubmed.ncbi.nlm.nih.gov/33167496/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857192/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007791https://www.sciencedirect.com/science/article/pii/S0264410X2030579Xhttps://www.pnas.org/content/107/37/16262https://www.sciencedirect.com/topics/medicine-and-dentistry/smallpox-vaccinehttps://www.nejm.org/doi/10.1056/NEJMoa032299?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0www.ncbi.nlm.nih.govhttps://www.cdc.gov/mmwr/preview/mmwrhtml/mm5227a5.htmhttps://www.the-scientist.com/news-opinion/texas-monkeypox-case-underscores-need-for-better-surveillance-69045http://outbreaknewstoday.com/monkeypox-drc-reports-600-cases-in-past-six-weeks-97477/https://emedicine.medscape.com/article/1134714-overviewhttps://www.statnews.com/2021/07/20/more-than-200-people-in-u-s-being-monitored-for-possible-monkeypox-exposure-cdc-says/https://www.cdc.gov/poxvirus/monkeypox/outbreak.htmlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857192/

U of Oregon Article:  https://www.oregonlive.com/trackandfield/2021/10/women-athletes-allege-body-shaming-within-oregon-ducks-track-and-field-program.html   Body composition of elite athletes: https://journals.sagepub.com/doi/10.1177/036354658301100604?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&   Overtraining or Relative energy deficiency? https://pubmed.ncbi.nlm.nih.gov/34181189/   Athlete triad in female and male ultrarunners https://pubmed.ncbi.nlm.nih.gov/34232162/   Position stance and overview of RED-S:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146210/

Learn about why you eat more when you're tired; a legendary submerged Egyptian city; and a trick for keeping the peace. Lack Of Sleep Really Does Make You Eat More by Ashley Hamer Sleep Munchies: Why It's Harder To Resist Snacks When We're Tired. (2016, March 2). NPR.org. https://www.npr.org/sections/thesalt/2016/03/02/468933610/sleep-munchies-why-its-harder-to-resist-snacks-when-were-tired ‌ Circadian Surprise: How Our Body Clocks Help Shape Our Waistlines. (2015, March 10). NPR.org. https://www.npr.org/sections/thesalt/2015/03/10/389596946/circadian-surprise-how-our-body-clocks-help-shape-our-waistlines  Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite | Annals of Internal Medicine. (2021). Annals of Internal Medicine. https://www.acpjournals.org/doi/abs/10.7326/0003-4819-141-11-200412070-00008  Hanlon, E. C., Tasali, E., Leproult, R., Stuhr, K. L., Doncheck, E., de Wit, H., Hillard, C. J., & Van Cauter, E. (2016). Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. Sleep, 39(3), 653–664. https://doi.org/10.5665/sleep.5546 ‌ Insufficient Sleep Undermines Dietary Efforts to Reduce Adiposity | Annals of Internal Medicine. (2021). Annals of Internal Medicine. https://www.acpjournals.org/doi/10.7326/0003-4819-153-7-201010050-00006?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&  We just found an ancient Greek military ship in the legendary SUBMERGED Egyptian city Thônis-Heracleion by Steffie Drucker  Berman, R. (2021, July 28). Ancient Greek military ship found in legendary, submerged Egyptian city. Big Think; Big Think. https://bigthink.com/surprising-science/thonis-heracleion  ‌Sharpe, E. (2016, May 16). British Museum dips its toes into world of underwater archaeology. Theartnewspaper.com; The Art Newspaper. https://www.theartnewspaper.com/news/british-museum-dips-its-toes-into-world-of-underwater-archaeology  ‌Reuters. (2021, August 10). Egypt finds ancient military vessel, Greek graves in sunken city. Reuters; Reuters. https://www.reuters.com/world/africa/egypt-finds-ancient-military-vessel-greek-graves-sunken-city-2021-07-19/  ‌In Photos: The sunken city of Thônis-Heracleion in Alexandria reveals new archaeological treasures - Heritage. (2020). Ahram Online; Ahram Online. https://english.ahram.org.eg/NewsContentP/9/417416/Heritage/In-Photos-The-sunken-city-of-Th%C3%83%C2%B4nisHeracleion-in-A.aspx  Writing about relationship conflicts from a third-person perspective can keep the peace by Steffie Drucker Expressive writing reduces relationship conflict and aggression during pandemic. (2021, August 10). EurekAlert! https://www.eurekalert.org/news-releases/924973  Rodriguez, L. M., Stewart, S. H., & Neighbors, C. (2021). Effects of a brief web-based interpersonal conflict cognitive reappraisal expressive-writing intervention on changes in romantic conflict during COVID-19 quarantine. Couple and Family Psychology: Research and Practice. Advance online publication. https://doi.org/10.1037/cfp0000173  Follow Curiosity Daily on your favorite podcast app to learn something new every day withCody Gough andAshley Hamer. Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers. See omnystudio.com/listener for privacy information.

Dr. Jordan Feigenbaum and Dr. Herman Pontzer discuss the Constrained Energy Expenditure Model, Metabolism, and more! Burn: https://www.amazon.com/Burn-Research-Really-Calories-Healthy/dp/0525541527 Papers: https://pubmed.ncbi.nlm.nih.gov/34385400/ https://journals.physiology.org/doi/full/10.1152/physiol.00027.2018?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org 2-Day Barbell Medicine Seminar: https://www.barbellmedicine.com/seminars/ Pain and Rehab Seminar: https://www.barbellmedicine.com/shop/events/pain-rehab-2-day-virtual-seminar/ For more of our stuff: Podcasts: goo.gl/X4H4z8 Website: www.barbellmedicine.com Instagram: @austin_barbellmedicine @jordan_barbellmedicine @leah_barbellmedicine @vaness_barbellmedicine @untamedstrength @michael_barbellmedicine @derek_barbellmedicine @hassan_barbellmedicine @michael_amato_barbellmedicine @charlie_barbellmedicine @alex_barbellmedicine @tomcampitelli Email: info@barbellmedicine.com Supplements/Templates/Seminars: www.barbellmedicine.com/shop/ Forum: forum.barbellmedicine.com/

In this episode, Marc and Mo are joined by special guest Javad Parvizi (James Edwards Professor of Orthopaedic Surgery at the Sidney Kimmel School of Medicine at the Rothman Institute at Thomas Jefferson University in Philadelphia) in a thought-provoking discussion on the goals and impact of international efforts to achieve consensus and standardization in orthopaedic care, with a specific focus on guidelines related to periprosthetic joint infection and venous thromboembolism. OrthoJOE Mailbag: feedback, comments, and suggestions from our audience can be sent to orthojoe@jbjs.org Links: Second International Consensus Meeting (ICM) on Musculoskeletal Infection. https://icmphilly.com/ Parvizi J, Gehrke T, Chen AF. Proceedings of the International Consensus on Periprosthetic Joint Infection. Bone Joint J. 2013 Nov;95-B(11):1450-2. https://online.boneandjoint.org.uk/doi/full/10.1302/0301-620X.95B11.33135?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Cam Akers achilles tendon rupture breakdown Citations: https://journals.sagepub.com/doi/10.1177/1071100720969633?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& https://journals.sagepub.com/doi/full/10.1177/2325967119830139 --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/edwin-porras/message Support this podcast: https://anchor.fm/edwin-porras/support

Are hot flashes taking over your life? Eek! Dr. Liz reviews two studies about hypnosis for hot flashes and lets you know if it's effective and if so, how effective! Study 1:  Clinical hypnosis in the treatment of postmenopausal hot flashes: a randomized controlled trial by Gary Elkins, William Fisher, Aimee K Johnson, Janet S Carpenter, Timothy Z Keith 2013 Mar;20(3):291-8. doi: 10.1097/gme.0b013e31826ce3ed. https://journals.lww.com/menopausejournal/Abstract/2013/03000/Clinical_hypnosis_in_the_treatment_of.11.aspx Study 2:  Randomized Trial of a Hypnosis Intervention for Treatment of Hot Flashes Among Breast Cancer Survivors by Gary Elkins, Joel Marcus, Vered Stearns, Michelle Perfect, M. Hasan Rajab, Christopher Ruud, Lynne Palamar, Timothy Keith https://ascopubs.org/doi/full/10.1200/JCO.2008.16.6389?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org -------------- Do you have Chronic Insomnia? Find out more about Dr. Liz’s Better Sleep Program at https://bit.ly/sleepbetterfeelbetter -------------------- See more about Dr. Liz and get Free hypnosis files at http://bit.ly/drlizhypnosis Search episodes at the Podcast Page http://bit.ly/HM-podcast Help yourself with Hypnosis Downloads by Dr. Liz! http://bit.ly/HypnosisMP3Downloads Twitter @DrLizBonet#hypnotizemepodcast | YouTube  |  FB  |  LinkedIn --------- A problem shared is a problem halved.In person and Online hypnosis for healing and transformation. Schedule your free consultation at https://www.drlizhypnosis.com. Listened to in over 140 countries, Hypnotize Me is the podcast about hypnosis, transformation, and healing. Certified hypnotherapist and Licensed Mental Health Counselor, Dr. Elizabeth Bonet, discusses the research behind hypnosis, interviews professionals doing transformational work, and talks to individuals who have had hypnosis. Free hypnoses are also given from time to time. If you're interested in learning more about the magic of hypnosis, psychotherapy and mindfulness, this is the perfect place to feed your fascination! Thank you for tuning in! Please subscribe to auto-download new episodes to your listening device.

Anthea is a registered dietitian at the private practice Culina Health and a freelance health reporter based in New York City. She received her Bachelor of Arts in Sociology from Emory University and is one month away from completing her Master's in Clinical Nutrition at New York University. She completed her clinical training at NYU Langone Health. Anthea believes that how and what we eat drives the way we feel, think, and live. She learned this firsthand during her time as a writer for Health magazine, where she worked with countless dietitians and doctors to craft stories about the impact of our food choices on our physical and mental well-being. This experience inspired Anthea to devote her career to helping others harness the power of real foods to stay well. She does this through one on one nutrition counseling and continues to work as a contributor covering food and nutrition for popular media outlets including Health.com, Livestrong.com, and BuzzFeed Health, among others.In the conversation we cover out common questions related to the link between food and medicine. We talk about intermittent fasting, vitamins, and vitamin deficiencies, best food to improve our immune system, healthy sugars, optimal time for fueling the workouts, effects of alcohol, as well as anti- and pro-inflammatory foods. Tune in to learn more! LINKSPersonal website: www.alivewellnutrition.comInstagram: @alivewellnutrition Private practice website: www.culinahealth.com Resources referred to in the conversation:Intermittent fasting:https://www.annualreviews.org/doi/full/10.1146/annurev-nutr-071816-064634?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmedhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/https://culinahealth.com/2020/07/08/intermittent-fasting-guide/Vitamin C for Immunity:https://pubmed.ncbi.nlm.nih.gov/17636648/https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/Gut Health & Immunity:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515351/ This podcast is brought to you by Emory Lifestyle Medicine & Wellness. To learn more about our work, please visithttps://bit.ly/EmoryLM

048:  Whats up with the MACROs?  Does it even matter what we eat and how much of each macronutrient?In this episode, Dr. Thomas Hemingway will discuss the common Macronutrients which make up our everyday diet, i.e. the Proteins, Fats and Carbohydrates and will discuss the proportions of them and how to determine what's best for you.Take a listen!Learn more about Thomas Hemingway, MD and upcoming episodes, tips, tricks and more here: www.modernmedicinemovement.com on Instagram at @modermedicinemovement or @alohasurfdocAsk to join his FREE Private Facebook health Group with weekly LIVE educational sessions entitled:Modern Medicine Movement Health and Wellness Grouphttps://www.facebook.com/groups/2543880582493990/?ref=shareAlthough Dr. Thomas Hemingway is a physician, he is NOT your physician and is NOT to replace your primary care physician/health care provider. This podcast is NOT to be construed as medical advice by Dr. Thomas Hemingway or the guests comments as they are opinion only and NOT medical advice. Please consult your physician/health care provider should you have any medical questions or before trying any new practice. Check out reference he referred to in the podcast:1.  Howell, Scott.  "Calories in, calories out" and macronutrient intake: the hope, hype and science of calories. American Journal of Endocrinology and Metabolism.  29 Nov 2017https://journals.physiology.org/doi/full/10.1152/ajpendo.00156.2017?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

This is the third AMA podcast I’ve done and it was a fun one!  Time stamps with questions I answer in this one are below. If you have questions for future AMAs send them to radicalhealth@heartandsoil.co!    Time Stamps:  0:11:08 Ask Me Anything! 0:13:21 What are the best labs to get done? 0:21:49 How do we most effectively share the animal-based lifestyle with friends and family? 0:24:34 Is a plant-based diet more financially sustainable than an animal-based diet? 0:27:03 Zach Bush, Tetrahydrate, and eating dirt 0:32:49 The Scoop on Candida 0:39:15 Natural Honey Lowers Plasma Glucose, C-Reactive Protein, Homocysteine, and Blood Lipids in Healthy, Diabetic, and Hyperlipidemic Subjects: Comparison with Dextrose and Sucrose https://www.liebertpub.com/doi/10.1089/109662004322984789?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 0:39:15 Why honey is different than other carbs 0:42:35 Paleoanthropology and the origins of modern disease Https://www.youtube.com/watch?v=3fewDdSUSwg 0:42:35 Why were the ancient Egyptians so unhealthy? 0:46:30 Nutrition and health in agriculturalists and hunter-gatherers https://www.proteinpower.com/nutrition-and-health-in-agriculturalists-and-hunter-gatherers/ 0:48:55 Earliest evidence for caries and exploitation of starchy plant foods in Pleistocene hunter-gatherers from Morocco https://www.pnas.org/content/111/3/954 0:58:53 Are peptide supplements legit? 1:03:23 Diet of ancient Egyptians inferred from stable isotope systematics https://www.sciencedirect.com/science/article/abs/pii/S0305440314000843 1:03:42 Reconstructing Ancient Egyptian Diet through Bone Elemental Analysis Using LIBS (Qubbet el Hawa Cemetery) https://www.hindawi.com/journals/bmri/2015/281056/ 1:04:38 Evidence for dietary change but not landscape use in South African early hominins https://pubmed.ncbi.nlm.nih.gov/22878716/ 1:05:10 Stable isotopes reveal patterns of diet and mobility in the last Neandertals and first modern humans in Europe https://www.nature.com/articles/s41598-019-41033-3 1:05:50 The lowdown on sulforaphane 1:07:20 Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism https://pubmed.ncbi.nlm.nih.gov/26946249/ 1:08:22 Sulforaphane Induces Oxidative Stress and Death by p53-Independent Mechanism: Implication of Impaired Glutathione Recycling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965485/ 1:14:10 Antioxidants in food: mere myth or magic medicine? https://pubmed.ncbi.nlm.nih.gov/22059961/ 1:15:50 Is linoleic acid really proven to be unhealthy? 1:15:59 Minnesota coronary experiment Https://www.bmj.com/content/bmj/353/bmj.i1246.full.pdf 1:16:04 Sydney Diet Heart Study https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.27.1_supplement.127.4 1:16:25 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans https://pubmed.ncbi.nlm.nih.gov/9844997/   -- Heart & Soil: Heartandsoil.co for grass-fed desiccated organ supplements White Oak: Use “CarnivoreMD” at whiteoakpastures.com Belcampo: Use “CarnivoreMD” or “Carnivore10” at www.belcampo.com Let’s Get Checked: www.trylgc.com/carnivoremd Cinder: cindergrill.com/pages/carnivoremd

Link para artigo: https://www.nejm.org/doi/10.1056/NEJMoa2021372?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed Nidorf SM, Fiolet ATL, Mosterd A, Eikelboom JW, Schut A, Opstal TSJ, The SHK, Xu XF, Ireland MA, Lenderink T, Latchem D, Hoogslag P, Jerzewski A, Nierop P, Whelan A, Hendriks R, Swart H, Schaap J, Kuijper AFM, van Hessen MWJ, Saklani P, Tan I, Thompson AG, Morton A, Judkins C, Bax WA, Dirksen M, Alings M, Hankey GJ, Budgeon CA, Tijssen JGP, Cornel JH, Thompson PL; LoDoCo2 Trial Investigators. Colchicine in Patients with Chronic Coronary Disease. N Engl J Med. 2020 Nov 5;383(19):1838-1847. doi: 10.1056/NEJMoa2021372. Epub 2020 Aug 31. PMID: 32865380. Contato: bemdespercebido@gmail.com

Mary Ruddick is a seasoned medical nutritionist who specializes in metabolic, immune, and nervous system disorders. She is the Director of Nutrition for CaptainSoup.com, Enable Your Healing, The REIGNS Method, and the Back to Joy Program, and she currently travels the globe studying traditional diets and seeing patients online via her private practice.   Time Stamps:   0:11:16 Mary's Dream Penthouse 0:13:09 Mary on the hippo turf 0:16:13 The lion hunt (No lions were harmed in the making of this podcast) 0:20:46 How separated we've become. 0:26:39 Mary Ruddick's backstory 0:39:06 How Mary beat dysautonomia 0:47:54 What the Greeks actually eat (The blue zones are a myth) 0:54:38 Sociodemographic and Lifestyle Statistics of Oldest Old People (>80 Years) Living in Ikaria Island: The Ikaria Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051199/ 0:55:08 Determinants of All-Cause Mortality and Incidence of Cardiovascular Disease (2009 to 2013) in Older Adults: The Ikaria Study of the Blue Zones https://journals.sagepub.com/doi/10.1177/0003319715603185?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 0:55:41 Simplicity, purpose, and community: the recipe for a long life 1:00:07 Mary's African adventure and lots of carnivory 1:12:42 Mary eats a raw adrenal gland 1:17:09 The diet of the Shona 1:24:47 The power of traditional diets 1:28:29 Some insight into Mary's practice 1:33:12 [Vitamin K paper] 1:37:55 The role of animal foods in fertility 1:40:15 Mary's closing remarks 1:40:46 Where to find Mary Ruddick Heart & Soil: Heartandsoil.co for desiccated organ supplements  White Oak: Use “CarnivoreMD” at whiteoakpastures.com Belcampo: Use “CarnivoreMD” or “Carnivore10” at www.belcampo.com Helix: Helixsleep.com/carnivoremd for $200 off your mattress Blublox: Blublox.com, use “CarnivoreMD” for 15% off

Find part 1 of this podcast with James, here.    Dr. James DiNicolantonio, is a Doctor of Pharmacy and a cardiovascular research scientist. A well-respected and internationally known scientist and an expert on health and nutrition, he has contributed extensively to health policy and has testified in front of the Canadian Senate regarding the harms of added sugars. He serves as the associate editor of the British Medical Journal’s Open Heart, a journal published in partnership with the British Cardiovascular Society, and is on the editorial advisory boards of several other medical journals. Dr. DiNicolantonio is the author or coauthor of over 250 publications in the medical literature. He also is the author of three bestselling health books, The Salt Fix, Superfuel and The Longevity Solution, as well as his newest book, The Immunity fix which you can find here. You can follow him on Instagram and Twitter @drjamesdinic and on Facebook at Dr. James DiNicolantonio. You can visit his website at drjamesdinic.com. Time stamps:    0:08:11 Podcast begins  0:09:16 How to create metabolic health  0:16:54 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(98)90067-9  0:19:55 Omega six fatty acids and oxidative stress  0:21:07 Premature atherosclerosis associated with monogenic insulin resistance https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&  0:22:00 Elevated Serum C-Reactive Protein and Free Fatty Acids Among Nondiabetic Carriers of Missense Mutations in the Gene Encoding Lamin A/C (LMNA) With Partial Lipodystrophyhttps://www.ahajournals.org/doi/10.1161/01.atv.0000047460.27435.b8?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed  0:32:46 Answering the fructose question and dispelling keto dogma  0:40:17 What nutrients are required for robust immunity  0:40:17 Is colostrum more effective than vaccines?  0:41:56 Prevention of Influenza Episodes With Colostrum Compared With Vaccination in Healthy and High-Risk Cardiovascular Subjects: The Epidemiologic Study in San Valentinohttps://journals.sagepub.com/doi/10.1177/1076029606295957?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&  0:43:07 Prevention of flu episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry study https://www.minervamedica.it/en/journals/panminerva-medica/article.php?cod=R41Y2010N04A0269  0:48:05 Some other helpful interventions  0:52:59 All about environmental hormesis  0:57:48 James' thoughts on time-restricted eating  1:42:35 Where to find James DiNicolantonio http://drjamesdinic.com/   Heart & Soil: www.heartandsoil.co    White Oak Pastures: www.whiteoakpastures.com code CarnivoreMD for 10% off first order   Belcampo: www.belcampo.com code CarnivoreMD for 20% off   Let’s Get Checked:  www.trylgc.com/carnivoremd  BluBlox: www.blublox.com, CarnivoreMD for 15% off

In Pilates there are SO many myths, so much baggage. So many convoluted pseudo-scientific theories about cueing. Luckily, the facts turn out to be quite simple. Much simpler than you'd think! There IS a best way to cue, and you can dramatically improve your cueing by using 3 simple techniques. Yay science!! Links Attentional focus and motor learning, a summary of the last 15 years of research https://www.tandfonline.com/doi/full/10.1080/1750984X.2012.723728 (here) Pilates Through The Ages - examples of how cueing has changed over the last 60 years https://breathe.edu.au/pilates-through-the-ages/ (here) Great paper on additive benefits of external focus, autonomy support and early success https://journals.sagepub.com/doi/abs/10.1080/17470218.2016.1276204 (here) My Gym Dad on Insta https://www.instagram.com/my_gym_dad/ (@my_gym_dad) OPTIMAL motor learning http://optimalmotorlearning.com/index.php/did-you-know-that/ (website) Stroke rehab study https://journals.sagepub.com/doi/full/10.1177/1545968318760726?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org (here) Raph interviews Dr Gaby Wulf and Dr Rebecca Lewthwaite https://breathe.edu.au/teach-movement-skills-gabriele-wulf-rebecca-lewthwaite/ (here) -------------------------------- Ways to engage with us for FREE Join ourhttps://breathe-education.com/pilates_elephants-register/ ( free weekly Q&A)  Get our free ebook onhttps://breathe-education.com/posture/ ( Posture Myths in Pilates) Connect on Instagramhttps://www.instagram.com/breathe.education/ ( Breathe Education),https://www.instagram.com/the_raphaelbender/ ( Raphael Bender),https://www.instagram.com/cloebunterpilates/ ( Cloe Bunter) and Facebookhttps://www.facebook.com/BreatheEducation ( Breathe Education) -------------------------------- Masterclasses and online courses Do ahttps://breathe-education.com/masterclasses/ ( Masterclass) with us Read more about thehttps://breathe-education.com/diploma-of-clinical-pilates/ ( Diploma of Clinical Pilates) -------------------------------- Have Questions? https://breathe-education.com/coachingcall (Book a time to talk with our team) Links may not work on some platforms. You'll find all the info athttps://breathe-education.com/podcast/ ( https://breathe-education.com/podcast/) This podcast uses the following third-party services for analysis: AdBarker - https://adbarker.com/privacy

Tucker Goodrich is a technology executive in the financial industry who designs, runs, and debugs complex systems in high-risk environments. Areas of expertise include risk management, systems management, and cyber-security.    After experiencing some personal health crises and realizing that the ‘solutions’ offered by medical professionals weren’t working or addressing causation he started applying the same approach in research and evaluation of data to his own health issues to determine root causes.    His interests have focused on dietary and environmental drivers of chronic disease, including carbohydrate, wheat, and various classes of fats. Specifically, he's attempting to understand and popularize understanding of the mechanisms driving the diet-derived explosion in so-called chronic diseases (or diseases of civilization). He is active on twitter (@tuckergoodrich, has a blog called Yelling Stop, is an Expert Advisor for the nutrition start-up Nutrita, and has been a guest on numerous podcasts. Time Stamps: Podcast Youtube 0:09:38   0:03:21   Podcast Begins 0:11:12   0:04:55   What is Linoleic Acid? 0:16:44   0:10:27   How Linoleic acid caused disease 0:21:06   0:14:49   Understanding cardiolipin and the electron transport chain 0:23:28   0:17:11   Linoleic acid drives mitochondrial dysfunction, causes chronic illness 0:26:41   0:20:24   Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026740/ 0:32:56   0:26:39   Linoleic acid is uniquely damaging 0:35:30   0:29:13   Myths surrounding linoleic acid 0:38:19   0:32:02   The supremacy of animal fats 0:41:05   0:34:48   Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA   https://journals.physiology.org/doi/full/10.1152/ajpheart.00480.2004?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org 0:42:25   0:36:08   How seed oil consumption leads to necrosis and CVD 0:49:38   0:43:21   Mainstream understanding of PUFAs is built on faulty epidemiology 0:56:21   0:50:04   Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failurehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909262/ 0:58:49   0:52:32   All about OxLAMs 1:03:32   0:57:15   Oxidized omega-6s are essential for atherosclerosis  1:13:33   1:07:16   Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/ 1:14:30   1:08:13   Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients   https://www.sciencedirect.com/science/article/abs/pii/S0009308497000959?via%3Dihub 1:15:38   1:09:21   The root cause of oxidative stress is linoleic acid 1:18:17   1:12:00   Metabolites of arachidonic acid and linoleic acid in early stages of non-alcoholic fatty liver disease—A pilot study   https://www.sciencedirect.com/science/article/abs/pii/S1098882315300101 1:19:56   1:13:39   How Linoleic acid affects immunity 1:44:03   1:37:46   The linoleic acid-chronic illness hypothesis is air-tight 1:48:14   1:41:57   Calories In, Calories Out is the wrong paradigm 1:51:01   1:44:44   Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/ 1:51:53   1:45:36   Eating seed oils is about as smart as eating poison ivy 1:54:54   1:48:37   Tucker Goodrich radical paleo evangelism 1:58:19   1:52:02   Where to find Tucker Goodrich Sponsors:   Heart & Soil: www.heartandsoil.co    Sacred Hunting: www.sacredhunting.com/paul   Chilipad/ Ooler: https://www.chilitechnology.com//CarnivoreMD   White Oak Pastures: www.whiteoakpastures.com code CarivoreMD for 10% off first order Belcampo: www.belcampo.com code CarnivoreMD for 20% off

Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop.   Time Stamps:   0:08:42  Podcast Begins 0:09:52  Peter's Background 0:16:36  The Electron Transport Chain 0:45:30  Insulin resistance is a cellular antioxidant defense mechanism   https://www.pnas.org/content/106/42/17787 0:47:50 High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates   https://www.researchgate.net/publication/5929069_High_rates_of_superoxide_production_in_skeletal-muscle_mitochondria_respiring_on_both_complex_I-_and_complex_II-linked_substrates 0:49:50  We need insulin resistance 0:54:53  All about a1a 1:00:37  How PUFAs affect mitochondria 1:02:40  PUFAs and cellular lipid accumulation 1:05:34  Pathological insulin sensitivity   1:07:52  Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4  https://www.sciencedirect.com/science/article/abs/pii/S1388198107002296?via%3Dihub 1:12:34  The center of metabolic health: the adipocytes  1:14:08  PUFAs and tumor growth 1:15:52  Eating the perfect ratio of fatty acids 1:20:18  Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets  https://academic.oup.com/jcem/article/89/4/1641/2844241 1:20:18  How PUFAs break your metabolism 1:23:20  Premature Atherosclerosis Associated With Monogenic Insulin Resistance  https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 1:25:21  Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/ 1:30:16  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/ 1:30:53  Context matters in interpreting lipids 1:36:49  You might want to rethink your avocado and olive oil 1:40:17  Plant are not benevolent 1:47:55  How to find Peter Dobromylskyj 1:51:01  Peter's radical running habits 1:53:54  Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet   https://www.cambridge.org/core/product/identifier/S0007114502000673/type/journal_article 1:55:42  The roots of the chronic disease epidemic 1:58:23  Diet Fat Composition Alters Membrane Phospholipid Composition, Insulin Binding, and Glucose Metabolism in Adipocytes from Control and Diabetic Animals  jbc.org/content/265/19/11143.long 1:59:29 Insulin-sensitive obesity   https://journals.physiology.org/doi/full/10.1152/ajpendo.00586.2009?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Heart & Soil is my passion based company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand and developing a US based supply chain. Check us out at: www.heartandsoil.co, @heartandsoilsupplements on Instagram  Belcampo: www.belcampo.com Use the code “carnivoremd” for 20% off your order!  Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order White Oak Pastures: Use the code CARNIVOREMD at www.whiteoakpastures.com for 10% off your first order!

Today we have a very special guest interviewer, Dr Yasmin Whately. She will be joining us from time to time on Deep Breaths to have in-depth chats with consultant anaesthetists about how they approach various procedures in different settings. Today, she discusses all things clot retrieval for acute ischaemic stroke with her guest Dr Wendy Morris. If you have any questions, comments or suggestions for future episodes, be sure to write to us at deepbreathspod@gmail.com. Thanks for listening, and happy studying. References for this episode include: https://journals.lww.com/anesthesia-analgesia/Fulltext/2019/04000/Anesthetic_Management_of_Emergency_Endovascular.15.aspx https://journals.lww.com/anesthesia-analgesia/Fulltext/2019/04000/Anesthetic_Management_of_Emergency_Endovascular.16.aspx https://www.ahajournals.org/doi/10.1161/STROKEAHA.113.003412?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 

If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not,  you’ve got some homework to do, and I think you’ll be  amazed at what you find. Dave’s work can be found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.    He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.   Time Stamps:   0:08:46  Podcast Begins 0:14:21  The Bradford Hill Criteria 0:15:29  Context matters in lipids 0:19:44  Carnivore MD's Lipid Panel 0:30:15  Why LDL can't be the root cause of CVD 0:35:57  Testing the Lipid Hypothesis  0:41:20  Why you can't look at LDL in a vacuum 0:47:38 High-density lipoprotein as a protective factor against coronary heart disease The Framingham study - The Framingham Study  https://www.amjmed.com/article/0002-9343(77)90874-9/pdf 0:49:19  Metabolic health is what really matters 0:52:01  Premature Atherosclerosis Associated With Monogenic Insulin Resistance  https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 0:54:19  LDL quality is what actually matters 1:00:39  What's the root cause of oxidized LDL?   1:06:20  Why most LDL lab tests are bonk! 1:07:41  Dave's latest experiment results 1:16:12  Summary of Dave's Energy Model 1:21:21  The body holds onto and reuses cholesterol. 1:24:28  The vital importance of ample cholesterol 1:25:40  Fasting Increases Serum Total Cholesterol, LDL Cholesterol and Apolipoprotein B in Healthy, Nonobese Humans  https://academic.oup.com/jn/article/129/11/2005/4721856 1:26:19  Brown Bears (Ursus arctos) Seem Resistant to Atherosclerosis ­Despite Highly Elevated Plasma Lipids during Hibernation and Active State  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439871/ 1:28:40  Strong increase in hydroxy fatty acids derived from linoleic acid in human low-density lipoproteins of atherosclerotic patients  https://pubmed.ncbi.nlm.nih.gov/9488997/ 1:30:45  Why PUFAs lower LDL and why this is a bad thing 1:32:56  Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a)  https://www.ahajournals.org/doi/10.1161/01.ATV.0000118012.64932.f4?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 1:32:56  Variables beyond LDL-- Lp(a) 1:37:50  Quantification of apo[a] and apoB in human atherosclerotic lesions   https://www.jlr.org/content/32/2/317.long 1:42:51  Metabolic health   greatly influences lipids 1:45:18  Citizen Science Foundation  https://citizensciencefoundation.org/ 1:47:58  Dave, the Radical human test tube!     Heart & Soil is my passion based company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand and developing a US based supply chain. Check us out at: www.heartandsoil.co, @heartandsoilsupplements on Instagram  Belcampo: www.belcampo.com Use the code “carnivoremd” for 20% off your order!  Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io,    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order   White Oak Pastures: Use the code CARNIVOREMD at www.whiteoakpastures.com for 10% off your first order! Force of Nature Regenerative meats: Forceofnature.com

The sources used in the making of this episode include: http://webjcli.org/article/view/574/749   https://journals.sagepub.com/doi/full/10.1258/jrsm.2008.071002?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&   http://webjcli.org/article/view/574/749   https://www.pressreader.com/uk/daily-mail/20181022/281973198633739   https://www.mirror.co.uk/tv/tv-news/beverley-allitt-trevor-mcdonald-killer-13473249   https://www.thesun.co.uk/news/10302948/beverley-allitt-police-murder-children-grantham/   https://www.biography.com/crime-figure/beverley-allitt   https://allthatsinteresting.com/beverley-allitt   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270251/   https://www.lincolnshirelive.co.uk/news/local-news/she-living-life-riley-beverly-2134671   https://www.youtube.com/watch?v=BDxagLOmz2s   https://www.youtube.com/watch?v=BDxagLOmz2s&t=475s   https://www.breakingnews.ie/world/child-killer-to-marry-vampire-attack-boyfriend-13433.html

The sources used in the making of this episode include: http://webjcli.org/article/view/574/749   https://journals.sagepub.com/doi/full/10.1258/jrsm.2008.071002?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&   http://webjcli.org/article/view/574/749   https://www.pressreader.com/uk/daily-mail/20181022/281973198633739   https://www.mirror.co.uk/tv/tv-news/beverley-allitt-trevor-mcdonald-killer-13473249   https://www.thesun.co.uk/news/10302948/beverley-allitt-police-murder-children-grantham/   https://www.biography.com/crime-figure/beverley-allitt   https://allthatsinteresting.com/beverley-allitt   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270251/   https://www.lincolnshirelive.co.uk/news/local-news/she-living-life-riley-beverly-2134671   https://www.youtube.com/watch?v=BDxagLOmz2s   https://www.youtube.com/watch?v=BDxagLOmz2s&t=475s   https://www.breakingnews.ie/world/child-killer-to-marry-vampire-attack-boyfriend-13433.html

Writer Michael Bishop reads his essay Primum Non Nocere: First, Do No Harm to start the show.  The essay is part investigative journalism, part creative non-fiction and interrogates the taken-for-granted practice of organ donation and recovery.  The Thriving crew discuss the essay, especially for how it illuminates what amounts to a kafkaesque custom.  In taking the wool away from our eyes, the discussion builds to using politically-informed art to uncover other taken-for-granted facets of our lives, especially ones more vivid in the pandemic.  CONTENT WARNING: The essay contains vivid descriptions of medical procedures including organ recovery surgery.  The story runs from minutes 6 through 22:30. Huge thanks to In Heaven by Drake Stafford for our intro song, A Time for Action by Kennedy for our outro, the prolific and enigmatic Joe Shine for the thumbnail art, the Normal School for Mike’s essay, and Kai Engel for the great suspense music. For the written version of Mike’s Primum Non Nocere essay at the Normal School. Mike mentioned a study that showed that 20% of unresponsive patients showed some level of awareness. I was wrong: it's closer to 10%. Careful examination revealed that some displayed very subtle signs of consciousness, but also that ~5% of patients showed zero outward signs of awareness yet were able to answer yes/no questions using fMRI. Here's an Aeon article from the researchers: https://aeon.co/amp/essays/new-therapies-offer-hope-for-people-trapped-by-disorders-of-consciousness and here's a link to the study (also linked in Aeon article) https://www.nejm.org/doi/full/10.1056/NEJMoa0905370?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed. This study provides an excellent overview of the crisis within neuroscience regarding the fiction of brain death: https://link.springer.com/article/10.1007/s10943-018-0654-7. Tuned-in: 

Join the Editors of The Journal of Psychedelic Psychiatry as they discuss Treatment-Resistant Depression with Special Guest and Psychiatrist Dr. Scott Aaronson. Dr. Scott Aaronson obtained his M.D. from Harvard University in 1981. He is currently an Associate Professor at The University of Maryland School of Medicine, a Distinguished Life Fellow of the American Psychiatric Association, a Fellow of The American College of Psychiatrists. He serves on the board of the American Society of Clinical Psychopharmacology and the board of the Clinical TMS Society. He currently is the Director of Clinical Research for The Retreat at Sheppard Pratt. Referenced Articles on Treatment-Resistant Depression: https://www.ncbi.nlm.nih.gov/pubmed/30974339 https://journals.sagepub.com/doi/abs/10.1177/0004867418808585?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=anpa Follow us: Website: https://www.journalofpsychedelicpsychiatry.org/ Twitter: https://twitter.com/psychedelic_org Facebook: https://www.facebook.com/JournalofPsychedelicPsychiatry/ Instagram: https://www.instagram.com/journalpsychedelicpsychiatry/

Episode #5 Management of Type 2 Diabetes Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve. In this episode, Dr. Donohoe and Garrett discuss the management of Type 2 Diabetes and the mechanisms of how diet and exercise are such powerful tools when trying to achieve optimal blood glucose levels. We also get into sleep and stress management in regards to blood sugar. PLEASE SUBSCRIBE TO THE PODCAST For more Diabuddies content follow us on The Diabuddies Podcast Facebook page. Twitter: @TheDiabuddies Instagram: @thediabuddiespodcast You can email us at TheDiabuddiesPodcast@gmail.com   Resources/Links Discussed in the episode: Richter, E.A., & Hargreaves, M., (2013). Exercise, GLUT4, and Skeletal Muscle Glucose Uptake. Physiological Reviews; 93(3):993-1017. https://www.physiology.org/doi/full/10.1152/physrev.00038.2012?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed Niu, Y., et al., (2017). Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner. BBA Molecular Basis of Disease; 1863(9):2372-2381 https://www.sciencedirect.com/science/article/pii/S092544391730220X?via%3Dihub Yin, J., Xing, H., & Ye, J., (2008). Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism; 57(5): 712-717. https://www.ncbi.nlm.nih.gov/pubmed/18442638 Wang, H., Zhu, C., Ying, Y., Luo, L., Huang, D., & Luo, Z., (2018). Metformin and berberine, two versatile drugs in the treatment of common metabolic diseases. Oncotarget; 9(11): 10135-10146. https://www.ncbi.nlm.nih.gov/pubmed/29515798 De Souza, JFT., Dattilo, M., de Mello, MT., Tuflk, S.,&  Antunes, HKM (2017). High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males. Front Physiol; 8: 992. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725446/ Ahmed, A. Bakrudeen Ali, et al. “In Vitro Callus and in Vivo Leaf Extract of Gymnema Sylvestre Stimulate β-Cells Regeneration and Anti-Diabetic Activity in Wistar Rats.” Phytomedicine, vol. 17, no. 13, 2010, pp. 1033–1039., doi:10.1016/j.phymed.2010.03.019. Al‐Romaiyan, Altaf, et al. “A Novel            Gymnema Sylvestre Extract Protects Pancreatic Beta‐Cells from Cytokine‐Induced Apoptosis.” Phytotherapy Research, 2019, doi:10.1002/ptr.6512. Kuo, Daih-Huang, et al. “Body Weight Management Effect of Burdock (Arctium Lappa L.) Root Is Associated with the Activation of AMP-Activated Protein Kinase in Human HepG2 Cells.” Food Chemistry, vol. 134, no. 3, 2012, pp. 1320–1326., doi:10.1016/j.foodchem.2012.03.023. Lan, Jiarong, et al. “Meta-Analysis of the Effect and Safety of Berberine in the Treatment of Type 2 Diabetes Mellitus, Hyperlipemia and Hypertension.” Journal of Ethnopharmacology, vol. 161, 2015, pp. 69–81., doi:10.1016/j.jep.2014.09.049. Lee, Woo Je. “α-Lipoic Acid Increases Insulin Sensitivity by Activating AMPK in Skeletal Muscle.” Biochemical and Biophysical Research Communications, vol. 332, no. 3, 2005, pp. 885–891., doi:10.1016/j.bbrc.2005.05.035. Magistrelli, Ashley, and Jo Carol Chezem. “Effect of Ground Cinnamon on Postprandial Blood Glucose Concentration in Normal-Weight and Obese Adults.” Journal of the Academy of Nutrition and Dietetics, vol. 112, no. 11, 2012, pp. 1806–1809., doi:10.1016/j.jand.2012.07.037. Viollet, Benoit. “Targeting the AMPK Pathway for the Treatment of Type 2 Diabetes.” Frontiers in Bioscience, Volume, no. 14, 2009, p. 3380., doi:10.2741/3460. Wei, Wei, et al. “A Clinical Study on the Short-Term Effect of Berberine in Comparison to Metformin on the Metabolic Characteristics of Women with Polycystic Ovary Syndrome.” European Journal of Endocrinology, vol. 166, no. 1, 2012, pp. 99–105., doi:10.1530/eje-11-0616.

החל מהראשון לינואר 2020 יסומנו רוב המוצרים הארוזים בסימונים חדשים. בפרק היום אני בודקת אם הסימון הזה מזיק יותר מאשר מועיל, ועוברת על כל מה שאדם בתזונה דלת פחמימות/קטו או בצום לסירוגין חייב לדעת עליהם.   נדבר על: * האם באמת חייבים להגביל שומן רווי ונתרן? * למה הסימון של הסוכר טוב...ולא טוב ביחד * למה הסימון הירוק לא לגמרי מתאים לנו * ואולי יש דווקא צדדים טובים בסימון התזונתי החדש ועוד ועוד.   לינקים: להורדת תפריט תזונה דלת פחמימות/קטו ומזונות מומלצים: http://rutifink.vp4.me/lchf-menu להורדת פרק החינם מהקורס אכילה לסירוגין לבריאות והרזיה כאן: https://rutifink.vp4.me/if-minicourse  לקורס המלא אכילה לסירוגין כאן: https://rutifink.vp4.me/if פרק החינם מהקורס לרזות בשפת הגוף כאן: https://www.rutifink.com/listentothebody לקורס המלא לרזות בשפת הגוף כאן: http://rutifink.vp4.me/sfathaguf-course  להרצאה מלאה ופרקטית על אכילה רגשית: http://rutifink.vp4.me/ee-lecture לקבוצת דלי פחמימות ישראל בפייסבוק: https://www.facebook.com/groups/970684026371234/ הצטרפו לקבוצת צום לסירוגין בפייסבוק: https://www.facebook.com/groups/186854445388951   רפרנסים: https://www.ncbi.nlm.nih.gov/pubmed/26417151 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31376-X/fulltext https://www.nejm.org/doi/full/10.1056/NEJMoa1311889 https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.118.11728?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Homelessness remains a persistent, societal and human rights issue that affects over 250,000 Canadians. The challenges go beyond just finding a place to live – those who are homeless or vulnerably housed have higher incidences of chronic mental and physical health problems and often face stigma while navigating the healthcare system. On this episode, we heard from different voices at the intersection of homelessness and health. We started our conversation with Linda Bingham from Working for Change, who shared her lived experience with homelessness and addiction and how she has now found her voice to tell her story for the very first time. We also spoke to Daniela Mergarten, who told us about her struggles to find stable housing, her experiences with the healthcare system, and her advocacy work with the Lived Experience Caucus of the Toronto Alliance to End Homelessness. Dr. Alissa Tedesco, a physician in the Palliative Education and Care for the Homeless (PEACH) program and co-chair of Health Providers Against Poverty (HPAP) Ontario, told us about the work being done on the frontline to address the healthcare needs of people who are homeless as well as some of the shortcomings of our healthcare and social service systems. Finally, Dr. Vicky Stergiopoulos, a clinician-scientist and physician in chief at CAMH, told us about her work looking at the effectiveness of a Housing First approach to improve housing stability and health outcomes amongst people experiencing homelessness. Linda Bingham's interview Daniela Mergarten's interview Voices on the Street, Working for Change Dr. Naheed Dosani TedX Talk Daniela’s CBC article on losing her home on Dovercourt PEACH Website Journey Home Hospice Mental Health Commission of Canada Paper by Dr. Vicky Stergiopoulos: Key Ingredients of a Cross-Section Partnership Extension of At Home/Chez Soi Study by Dr. Vicky Stergiopoulos The Upstream Lab Health Providers Against Poverty (HPAP) HPAP Report Card A Housing First success story Partnership to create affordable housing (University Health Network, United Way of Greater Toronto, City of Toronto) Toronto Alliance to End Homelessness The Street Health Report"Too Little Too Late: How we fail vulnerable Canadians as they die and what to do about it"

How does a potential drug discovered in the lab ultimately end up in people? We tackle this question in the context of exciting gene-modifying therapies called antisense oligonucleotides (ASOs). In this episode, we speak with Dr. Tim Miller to break down the science behind ASOs and learn more about his work in finding a cure for a genetic form of amyotrophic lateral sclerosis (ALS). This episode was written and produced by Nancy Cai, Devika Nair, and Arja Ray. Music used in this episode: “Thannoid”, “Bundt”, “Lupi”, “Partly Sage”, “Beignet”, “Trailrunner”, “Game Hens”, “Lord Weasel”, “The Zeppelin”, “Dorica”, “Our Fingers Cold”, “Gaena” by Blue Dot Sessions For more information about spinal muscular atrophy (SMA), check out the spinal muscular dystrophy association website: https://www.mda.org/disease/spinal-muscular-atrophy. There is also this great animation that shows how the Spinraza (nusinersen) ASO works in the body: https://www.spinraza.com/en_us/home/taking/how-spinraza-works.html. To read the results from the first ASO for Huntington’s disease, check out the New England Journal of Medicine article here: https://www.nejm.org/doi/full/10.1056/NEJMoa1900907?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed.

Here's our links to some of the studies we refer to.Ethical failings of CPSO policy and the health care consent act: case review.https://bmcmedethics.biomedcentral.com/articles/10.1186/s12910-019-0357-yOutcomes and Cost of Patients With Terminal Cancer Admitted to Acute Care in the Final 2 Weeks of Life: A Retrospective Chart Reviewhttps://journals.sagepub.com/doi/abs/10.1177/1049909119843285?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=ajhbResource Optimization Network website: https://www.resourceoptimizationnetwork.com/Follow us on twitter: @KwadcastEpisode transcripts:Kwadwo: 00:01 Welcome to solving healthcare. I'm Kwadwo Kyeremanteng. I'm an ICU and palliative care physician here in Ottawa and the founder of resource optimization network. We are on a mission to transform healthcare in Canada. I'm going to talk with physicians, nurses, administrators, patients and their families because inefficiencies, overwork and overcrowding affects us all. I believe it's time for a better healthcare system that's more cost effective, dignified, and just for everyone involved.Kwadwo: 00:37 For our very first podcast, I'd like to introduce dr Gianni D'Egidio. He is first off, a very good friend of mine who does critical care and general internal medicine at the Ottawa hospital. In this episode we'll talk about the impact of providing inappropriate care to patients and also discuss how to manage conflict in these circumstances. Gianni D'Egidio. Thanks for joining us. My pleasure. Um, first of all, I'd like to thank you for coming, considering that I completely dominated you in an arm wrestle not that long ago in front of many people in Clearwater, Florida. So I'm very grateful for you to be appearing on the show today. Thank you. Well, I see this podcast is going to be full of lies today. All right, we're off with a bang. Okay. So as an intensivist, as a general internist, where do you see the problems in our healthcare system?Kwadwo: 01:36 I would have to say from my perspective, the biggest problem has to do with our lack or inability to correctly have an end of life care discussion or goals of care discussion. Now these terms are going to be interchangeable. Let's just say, uh, the term I'll use is, is proposing an adequate treatment plan to people. Okay. And the reason that is important, uh, is because what it results in is basically what you see right now in our entire healthcare system is a tremendous backlog. Everything is full. Uh, the hospitals are full, longterm care facilities are full. And I think one of the biggest problems we have is an inability to deal with these issues, namely having inappropriate, uh, discussion with substitute decision makers or patients about their overall prognosis and their overall care.Kwadwo: 02:25 So, okay. So that's the problem. And where do you see this bottlenecking? Is this within family practices? Are we doing this within a tertiary care centers? Like where do you see this mostly being a problem?Gianni: 02:38 Tickets from a continuum of starting with family practice? I think it can start there. It is rare that a family physician will have a well-informed, uh, advanced care planning session with their patients. And that then results in potentially, uh, an inappropriate admission to, and then when that admission to hospital comes, now let's take it into the acute phase where there is also probably an either ill informed or inappropriate conversation during the admission process, either through the emergency physician or the admitting physician. And then that progresses to further potential deescalate or excuse me, worsening of the patient in hospital and then results in a intensive care unit admission. Okay. Without giving a co like a exact patients scenario, walk us through exactly like what this could look like. So for instance, let's use one of our studies as an example. Okay. We looked at people presenting to the emergency department who subsequently died in the last, they were basically in the last two weeks of their life.Gianni: 03:45 Uh, these were people with advanced cancers, metastatic cancer who present to the emergency department and subsequently died within two weeks. 71% of those individuals who clearly had end stage disease, 71% of those individuals did not have any discussion regarding end of life or advanced care planning. So there's a typical example of our system of a failure of our system. And this is not to put blame on oncologists or a family physicians or intensivists. This is to say that the vast majority of people or the vast majority of physicians are either uncomfortable with having that discussion or are improperly educated about how to have that discussion. Interesting. So obviously we do the same line of work. We see this problem all the time. And what do you think, you kind of answered the question, but what do you think is the problem? Like if we know it's an issue with addressing goals of care, why isn't it happening?Gianni: 04:45 I would boil it down to two major issues. One is education amongst not only patients and substitute decision makers, but amongst physicians. And the second problem is fear. Um, or uncomfort or whatever you wanna label it as I would label it as fear and on the aspect or on the side of physicians especially that they are fearful of having these conversations, especially when the conversation is going to be fraught with emotion or conflict. So let's get back to 2.1 if I may about education when I, this is just anecdote, when I pull the medical students and residents that are in a lecture and I give many talks on end of life care, advanced care planning or proposing a treatment plan, I pull them on. I ask how many of you have had any education whatsoever in medical school about how to deal with conflict or how to have an appropriate end of life care discussion or advanced care planning discussion.Gianni: 05:43 The vast majority raise their hand and say, we have not had that type of education. If we had had that education, it's only been for an hour or one lecture and that is it. So here are these medical students now residency. And then I asked the residents the same question and again the vast majority lack that education or that formal teaching on it. They say they pick it up from their attendings. Well I've got news for everybody. If your attending is not very good at having that conversation and they are going to be your role model or your source of education for that a topic, I've got news for you, your end of life care discussion or advanced care planning discussions are also going to be quite poor. So education is tremendously lacking and then that results I think in point number two which is fear.Gianni: 06:31 We as physicians I think are, I as mentioned uneducated when it comes to having discussions that results in fear of having the discussions or avoidance of having these discussions. Let's look at the small percentage of conversations or families or substitute decision makers that are quote unquote difficult and we know they're going to be difficult. Physicians are fearful of having those conversations completely fearful and that we'll use the term almost cowardly. Um, when it comes to having those conversations, especially when they substitute decision maker or family member is threatening with a lawsuit or threatening to go to the media or whatever it may be that they're using. Um, physicians will avoid that conversation and if they're not avoiding the conversation, the conversation will basically allow the substitute decision maker to guide the treatment at that point. Like I couldn't agree more. And one of the things that people don't appreciate is the downstream consequences of these lack of conversations.Kwadwo: 07:32 So yes, the patient gets admitted to an inpatient or into the intensive care unit, they get all this treatment, which people don't realize how, how much of a strain it is for the family member, for the patient, for the care team, for, you know, having that moral distress of giving, like providing care to someone that's not going to benefit. So you've been involved in several cases where there's been conflict with the treating team and the family or substitute decision makers. I'm wondering if you could talk about that process a little bit and, and maybe even describe what the experience has been like for the patient. The family, the care team and yourself. So the, for those that are listening that don't know what the consent capacity board is, the consent and capacity board or the CCB is an independent quasi judicial tribunal. I'm appointed by the province to basically adjudicate what is in the best interests of a patient, especially when there is a conflict or dispute between what the treatment team feels is in the patient's best interest compared to what the substitute decision makers feel is in the best interests of their loved one.Gianni: 08:55 Um, Ivan and involved, uh, in six consent and capacity board cases and also been involved indirectly in multiple other cases. And I'll talk about, uh, our study a little bit later on. So regarding the CCB, um, the CCB as mentioned as closer judicial, it's basically a, uh, court like, um, a system or court like, um, process where me as the, uh, treating physician will file an application with a consent capacity board to basically, um, challenge whether or not the substitute decision maker is abiding by the principles of substitute decision making, which is section 21 of the health care consent act. And what that section 21 looks at is as mentioned, the principles of substitute decision making and a substitute decision maker. If I can make one clear point on this podcast today and what I do during my lectures as well, a substitute decision maker is only there to consent to the treatment plan that physicians propose and they have to do so based on number one previously expressed wishes of their loved one and if there's no previously expressed wishes, then they have to act on best interests.Gianni: 10:01 A which considers values and beliefs substitute decision makers are not there to demand therapy, they cannot demand therapy and they are only there to consent. Like I said to the treatment plan that we propose and this goes back to our education and our inability to appropriately propose a treatment plan. So in terms of their demand of therapy, we as physicians are not obliged to offer, propose or initiate any therapy that has not been started or that will not benefit the patient in our opinion. Okay. That's what we forget all the time on our side. Substitute decision makers like me, like I mentioned have to act on previously expressed wishes and if not best interest and the consent capacity board will basically adjudicate, um, solely based on law and solely based on the section 21 of the health care consent act. So I filed a six applications.Gianni: 10:59 I've been involved in five consent and capacity board hearings. Um, they are the consent capacity board. I guess the pearls of the consent and capacity board are that it is heard more end of life cases than any other court's combined in Canada. It is supposed to be rapid in the sense that once I file an application you're supposed to hear, there's supposed to be a pre hearing within one week of filing of that application and it's supposed to be much faster than the court system. Ideally you're having a pre hearing within a week and then ideally you're having the hearings within a month or two. Unfortunately that has been changing over time and I'll get into that maybe a little bit later on. So getting back to the pro, it's supposed to be fast. And more importantly when the hearing is done, you get your reasons for decision within 24 hours, which is unheard of compared to any other court Lake system.Gianni: 11:49 Um, the cons of the consent capacity are that the decision is solely based on law. It does not factor in the ethics, the opportunity costs, the medical standard of care or whatever else physicians would deem important. When it comes to proposing a treatment plan or it comes to the care of a patient, it's solely based on, like I said again this subsection 21 of the health care consent act. Um, my experience with the CCB has been mixed. I would say, um, lately the from filing of application to decision has been three to four months, which albeit is still faster than the court system. However, it is still, uh, quite arduous in terms of the amount of preparation that requires and the amount of time in spent in hearings. So the latest case that I've done, basically it was a seven day process, uh, not to mention the multiple pre hearings beforehand.Gianni: 12:47 So it can be quite labor intensive. And the reason I mention all this is because the vast majority of physicians will not proceed with a consent capacity board case. Um, I have done six, I know of in Ottawa at least, there's only been basically two other physicians who have filed a form G application, which deals with end of life care issues at the consent capacity board level. Um, so the vast majority of physicians will avoid it. And another factor is even if the reasons of decision, um, I hate to use a term but are favorable for the physician, let's say they find that the consent capacity or the, excuse me, that the substitute decision makers have not acted in the best interest of their loved ones that can be appealed. And then the appeal process will take another five to six months. And, uh, only adding to the workload and time for said physician involved.Gianni: 13:37 In that case, not only is there the workload or the never ending aspect of the consent capacity board cases, but it can also potentially result in litigation. So you can understand why the vast majority of physicians will not want to pursue this Avenue. Then getting into your point about the effect it has on families, a more substitute decision makers. While you can say goodbye to the therapeutic relationship that's essentially over, once you file that form G application or start mentioning courts and lawyers and whatever else. So the therapeutic relationship completely breaks down there is going to be most likely an associated costs for the substitute decision maker because they will have to retain legal counsel. If they can afford legal counsel then great. Yes they will. They will have to basically a fork out their own money for that process. If they can't afford it then they can get legal representation through legal aid.Gianni: 14:29 Um, so you have not only the financial burden for substitute decision makers, you have the therapeutic relationship breaking down and there is no doubt is a stressful for substitute decision makers as well. Right. Going through court is not a fun process for anyone involved. So you got into the technical aspect which fine, but like why are you doing it? Like are you seeing that is driving you to want to go through this process? Like give us a sense of what a patient is going through at the time where you, you, you decide I'm going to go through this process again, this comes at um, you have to remember that consent capacity board cases are open to the public and the reasons for decision are available to everyone. So what I am disclosing, I'm not disclosing any personal health information or anything like that and I have written about this.Gianni: 15:22 I have also used these experiences in the consent capacity board but that there is no doubt in my mind and no doubt, um, in the eyes of any of the healthcare team involved that the patient is absolutely suffering. And I will use extreme examples from cases, um, where basically there are profound ulcerations of the skin because of immobility and despite how good our nurses and our healthcare team is with moving patients, repositioning them, whatever else. Those are absolutely unavoidable. In these situations, you are dealing with an individual who is completely basically comatose who is now in one case was on months and months of vasopressin. I've got news for people. If you put someone on months of vasal pressers, you are basically, their skin has zero flow, it will have very, very poor blood flow. You combine that with pressure and the next step is profound ulceration to the point of sloughing of skin in multiple areas.Gianni: 16:25 And in one instance basically a complete degloving of a scalp from simple, um, bedside combing of the hair, um, that has happened, that has been documented. Um, and the same process will happen with any indwelling tube, uh, and breakdown. So for instance, rectal tubes, rectal tubes will result in the complete destruction of the rectum if it is unbelievable to see what will happen to these individuals. Um, so first and foremost it comes down to the suffering of a patient. And second, it comes down to just the injustice and uh, ethical dilemma that it presents to physicians. And that results in me basically bottom line, full disclosure being absolutely angry about the entire process. I could feel the anger in the room right now. But yeah, I gotta say I've seen you in and around a couple of cases and this is not easy getting back to like the reasons to do this. So I couldn't agree more that the cases that we see in the ICU have these prolonged uh, treatments where the patients aren't benefiting and it's been driven by the families, the amount of sufferings, insane. And one thing that goes under appreciated is the work our nurses are a allied health team members go through to to provide care. Like I'll never, when I was a fellow,Kwadwo: 17:50 we were rounding on one of these patients that weren't going anywhere and the nurse was crying in the corner, like trying to hide that she was getting emotional. I'm like what's the matter? Like what's going on? And she's like, every time I walk into that room I feel like I'm torturing that patient. I'm like 12 hours of torturing this poor guy. And it was actually a huge epiphany for me because like when we get involved, we're involved for like five to 15 minutes, right? To do our assessments or whatnot and they're at the bedside for 12 hours doing this. You know, it comes down to for me, you know, in terms of the justice point of view, like people don't realize also about the financial burden that is being put into this. Like into cases that people aren't benefiting in. You know, 1% of your gross domestic product goes into treating people in the ICU.Kwadwo: 18:51 A reasonable percentage of these, those people aren't benefiting. And we need to think about some of the opportunity costs. A colleague of ours, Michael Harwich, he was talking to us about his kid who has a, I think there's a breakfast program at his school where they, for underprivileged kids, they provide food for, uh, to ensure that they get nourished and they had to cut the program cause they were short money. And I'm like, this is insane. We are flogging some people that would never want cake, would never want treatment and we can't feed kids like, you know, get all that is.Gianni: 19:30 So let's, let's, that's a perfect segue into the next study that, uh, I or we are doing and will be presented at the Canadian critical care forum. Uh, in November there were 12 patients. Uh, let's, this is a case series of 12 patients that I've been directly involved in. And just off the top of my head, picked 12 patients that have been these, let's say drastic cases or extreme cases, but these 12 patients had a median age of 83 years old. They were meeting median age of all 83.5. So let's round up to 84. Let's just do that. Fair enough. They had an average length of stay in hospital of 263 days. Okay. That is absolutely I think incredible. And their average ICU length of state was 109 days. All 12 of these patients died. All 12 of these patients had extreme cognitive impairment, either the vast majority through dementia.Gianni: 20:25 And three, if I remember off the top of my head, three out of the 12 cases due to a severe interest cerebral, um, incident. Um, so as mentioned, all of these folks, unfortunately, well I should say all of these patients, I shouldn't use the term folks. All of these patients pass away the average cost of these 12 patients to our system, not including physician costs or any other, these are just indirect and direct costs. Nearly $8 million for these 12 patients. One patient spent 704 days in hospital. Now you cannot tell me that this is a wise use of our resources when we talk about opportunity costs. Now let's talk about the things this study didn't capture. Multiple nurses have quit and I know that directly, uh, multiple nurses have sought sick leave because of this. Um, we have had, um, there, there has been a tremendous um, decrease in the sort of wellbeing of our health care team.Gianni: 21:26 When these cases happen or even after the fact, you could feel it. Yes, yeah. Yes. And it has scarred certain individuals, scarred individuals to the point where they have quit. They have left their position. And these are not junior nurses. These are nurses in mid career who have decided I have seen enough. This is this case in particular has pushed me over the edge. I will not, I will no longer be an intensive care unit nurse. And you know what's insane? It's like their whole mantra of their whole job is to like, I want to make people better. I want to help heal people. I want to help them get their function back and they get shat on to get verbally abused. They get inundated with all this. They have the moral distress and they often feel powerless. Yes. You know what I mean? And it's like we need to do some shit about this.Gianni: 22:20 So this is, this brings us into another part of the bigger problem, which is as physicians in a healthcare team, besides the roots of the consent capacity board, the odds are stacked against the healthcare team right now. And if I may use the analogy of, of the pendulum, the pendulum has swung far too much towards the principle of autonomy. And I will refer people to the study that we recently published as well about the ethical failings of the end of life care or CPSO end of life care policy. And the health care consent act, which are completely favoring autonomy and they completely disregard other ethical principles such as distributive judge justice, non-maleficence and beneficent, excuse me. Um, and the reason that is our policies and law are completely stacked against um, those ethical principles and completely favor autonomy. For instance, the CPSO end of life care policy, which basically just to summarize, basically says you need consent not to perform CPR.Gianni: 23:22 This is the only treatment that I am aware of that has ever been or deemed by the college or any, uh, professional body to be uh, universally indicated in everyone. And as I point out, again, when I lecture my med students and residents, there is no treatment that is universally indicated in any one. I use the simple things like water and oxygen. Oxygen is not universally indicated and everyone, in fact, oxygen can be harmful when not indicated. Water is not universally indicated in everyone. For instance, in the hyponatremic patient, there is no way that CPR is universally indicated in every single individual. They are going to be clear cases where CPR will never benefit in an individual and should not be offered. I mean you and I both know how insane that that statement was. Like just to be clear for the listener, like you could have a patient with end stage cancer.Kwadwo: 24:13 You have a patient that is having end stage renal function. I, he needs dialysis and the treatment, the treating team says like this patient is not a, uh, is not a candidate for further chemo. They're not a candidate for further dialysis. They're not tolerating it. This ruling would still say that if they die you would need consent not to do CPR. Correct. Which is insane. Now, one of the things we as physicians, and this gets back to again, the uh, topic that I've been focusing in on is our proposal of treatment plans is very poor. And as I mentioned earlier, we do not need to offer any treatment or propose any treatment or begin any treatment that has not already been initiated or that's not going to be beneficial to an individual. However, that requires that the entire treatment team be on the same page.Gianni: 25:06 And you have to remember our healthcare system or the way we operate in intensive care unit, I don't want to call it fragmented, but we have a most responsible physician or attending physician every week. Right. And to get consensus for let's say 20 individuals, 20 physicians who are going to be looking after this patient, there's going to be a different level of comfort amongst those attending physicians about what they're gonna offer and not offer for fear of reprimand because of a lawsuit, a college complaint or whatever else it may be. Even though said physician completely agrees that this treatment should not be offered, but they are fearful of the consequences of saying I am not going to offer dialysis. I am not going to offer peg tube feeding. But they are fearful of the consequences of that. I mean is because of the process. Like just to be the devil, the process.Kwadwo: 25:52 Once you get a complaint, you get named in a lawsuit. That's years of your life. Yes. You know what I'm saying? And, um, so there is a lot of unfortunate the deterrent to be able to stand up and do what's right. But I think at the end of the day, all of us gotta look ourselves in the mirror, yo. And full disclosure, I have had a college of physicians and surgeons complaint, um, which took 15 months to basically resolve. I have had complaints to the chief of staff of the hospital to the CEO of the hospital, to my member of parliament as well. So these are, and I'm willing to deal with those. Uh, but again, I don't, I can't blame my colleagues for saying I don't want any of that. Especially if there is something else going on in their life that has providing them stress in their personal life or their academic career, whatever it may be. Right. They're going to completely avoid that. And part of me can't blame them.

(Cápsula 017) DESCRIPCIÓN: Los tatuajes son un fenómeno mundial cada vez mas frecuente. Se desconoce el efecto de los mismos en el lupus eritematoso sistemico. Cada vez es mas comun que las personas con lupus eritematoso sistemico busquen consejeria medica en cuanto a la relaizacion de tatuajes. Este es el primer estudio de seguridad de tetuajes en lupus eritematoso sistemico. ENLACE: https://journals.sagepub.com/doi/abs/10.1177/0961203319867395?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=lupa#articleShareContainer

Discussed in this episode are the following issues related to the health crisis sweeping the earth like a noxious plague:What does it mean to be healthy?The epic breakdown of human healthThe name given for this breakdown of healthDefinition of metabolic syndrome3 Maxims for optimum healthEpisode References:Definition health from a systems biology standpoint: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30092-XLeading causes of death in the US: https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htmObesity rates in the US: https://www.cdc.gov/obesity/data/adult.htmlPrevalence of diabetes in the US: http://www.diabetes.org/diabetes-basics/statistics/Heart diseases statistics in the US: https://www.cdc.gov/heartdisease/facts.htmCriteria for Metabolic Syndrome: https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.109.192644?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3DpubmedSelected metabolic syndrome rates worldwide: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-017-4041-1 Sleep cleans the brain: http://science.sciencemag.org/content/342/6156/373Effect of stress on human health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380124/pdf/dmj-36-207.pdf

Dr, Leila Mureebe, associate professor at Duke University, chats with us about academic vascular surgery, health economics, how to improve bedside dopplers, coping with the loss of a patient, music in the OR, her passion for sailing and much, much more!   (0:22) Leila Mureebe, MD, MPH full biography: https://surgery.duke.edu/faculty/leila-mureebe-md-mph   (6:14) SVS Transition to Practice YouTube Channel: https://www.youtube.com/playlist?list=PLNudqPjHpUmfY_liIzhzsmaVRlByv8SU4   (7:57) Publication by Dr. Mureebe addressing bundled payments and addressing value-based care in vascular surgery: https://www.ncbi.nlm.nih.gov/pubmed/27531088   (8:50) Registries NSQIP: https://www.facs.org/quality-programs/acs-nsqip VQI: https://www.vqi.org/ NCDR: https://cvquality.acc.org/NCDR-Home   (10:03) MD Epinet: http://mdepinet.org/   (11:33) TransCarotid Arterial Revascularization (TCAR): https://silkroadmed.com/the-tcar-procedure/   (14:40) 2016 AHA/ACC Guideline on the Management of Patients with Lower Extremity Peripheral Artery Disease: https://journals.sagepub.com/doi/full/10.1177/1358863X17701592?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed   (17:50) Doppler Analysis: http://symposium.scvs.org/abstracts/2018/P109.cgi   (22:18) SAAAVE Act: https://vascular.org/news-advocacy/saaave-act-background

Although DNA is often treated as the end-all in individual differences, it's not just about the blue print of the body. Ittai studies genetic regulation, or how DNA is expressed (or isn't). In this episode, we dive into his research techniques and talk about what it means to be human. Smithsonian DNA explainer: http://humanorigins.si.edu/evidence/genetics Genetic differences between humans & other primates: https://www.scientificamerican.com/article/tiny-genetic-differences-between-humans-and-other-primates-pervade-the-genome/ Evolution of gene regulation in humans: https://www.annualreviews.org/doi/full/10.1146/annurev-genom-090314-045935?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed Follow Ittai Eres: @IttaiE, ittai.eres@gmail.com Follow me: PhDrinking@gmail.com, @PhDrinking, @SadieWit, www.facebook.com/PhDrinking/ Thanks to www.bensound.com/ for the intro/outro Thanks to @TylerDamme for audio editing

Topics: achilles tendon, achilles tendinopathy, rehab achilles, bursae, marathons, vapourfly, shoes, shoe fit, gait, gait problems, gait correction, gait retraining, running, foot strike, heel strike, midfoot strike, rearfoot strike, heel strike, loading responses, gait rehab, muscle strength, isotonics Links to find the podcast: Look for us on iTunes, Google Play, Podbean, PlayerFM and more. Just Google "the gait guys podcast". Our Websites: www.thegaitguys.com doctorallen.co summitchiroandrehab.com shawnallen.net Our website is all you need to remember. Everything you want, need and wish for is right there on the site. Interested in our stuff ? Want to buy some of our lectures or our National Shoe Fit program? Click here (thegaitguys.com or thegaitguys.tumblr.com) and you will come to our websites. In the tabs, you will find tabs for STORE, SEMINARS, BOOK etc. We also lecture every 3rd Wednesday of the month on onlineCE.com. We have an extensive catalogued library of our courses there, you can take them any time for a nominal fee (~$20). Our podcast is on iTunes and just about every other podcast harbor site, just google "the gait guys podcast", you will find us.   Topics and links: The tendinopathic Achilles tendon does not remain iso-volumetric upon repeated loading: insights from 3D ultrasound. Nuri L, et al. J Exp Biol. 2017. https://www.ncbi.nlm.nih.gov/m/pubmed/28620014/ Good tip to decrease loading and help decrease injury risk in runners: See study by Chan et al.: http://journals.sagepub.com/doi/abs/10.1177/0363546517736277?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed& Vapourfly shoe https://www.nytimes.com/interactive/2018/07/18/upshot/nike-vaporfly-shoe-strava.html Men's marathon: https://twitter.com/chrisbramah/status/1019481750039343104/photo/1 fun facts: Foot strike patterns of the World Championships Marathon: Women's race: 73% rearfoot, 24% midfoot, 3% forefoot Men's race: 67% rearfoot, 30% midfoot, 3% forefoot pic.twitter.com/iWRzjImQBZ https://www.iaaf.org/about-iaaf/documents/research#biomechanical-research-projects Foot structure and stiffness is critical https://www.nature.com/articles/srep29870 Tendons can change Progressive calf strength training led to increased achilles stiffness @ 4 weeks & increased tendon cross sectional area @ 8 weeks https://link.springer.com/article/10.1007/s00421-018-3904-1 Bursae can thicken painlessly as a normal adaption to activity... just like skin calluses! https://www.ncbi.nlm.nih.gov/pubmed/24907190 Between 63-72% of participants were wearing incorrectly sized footwear. review of the literature here from @LTPodiatry team: https://jfootankleres.biomedcentral.com/articles/10.1186/s13047-018-0284-z How Neuroscientists Explain the Mind-Clearing Magic of Running -- from the Science of Us https://www.huffingtonpost.com/science-of-us/how-neuroscientists-expla_b_9787466.html

Brandon & Stephanie engage in a discussion on the Step 2 Clinical Skills Examination controversy with three special guests: Dr. Hillary Johnson a dermatologist from University of Iowa, Dr. Deland Weyrauch a resident physician at Yale University, and James Price a medical student from the Medical College of Wisconsin. They discuss the history of the exam, the layout of the exam, pros and cons of the test, vast amounts of evidence regarding the test and student/patient outcomes along , the organizations and people behind the test, steps beyond state medical association for change, their opinion based on the evidence on a national  standardized skills exam in medical education, and much more! United States Medical Licensing Examination Website: https://www.usmle.org/  Federation of State Medical Boards Website: http://www.fsmb.org/  National Board of Medical Examiners  Website: https://www.nbme.org/  AMA Council of Medical Education: https://www.ama-assn.org/about-council-medical-education  American Medical Association Website: https://www.ama-assn.org/  Accreditation Council for Continuing Medical Education Website: http://www.accme.org/    References: Archer J, Lynn N, Coombes L, et al. "The impact of large scale licensing examinations in highly developed countries: a systematic review". https://www.ncbi.nlm.nih.gov/pubmed/27543269    Burdick et. al. " Can We Increase the Value & Decrease the Cost of Clinical Skills Assessment" https://www.ncbi.nlm.nih.gov/pubmed/28834846    Winward et. al. "The Relationship between communication scores from the USMLE Step 2 Clinical Skills examination and communication ratings for first-year internal medicine residents". https://www.ncbi.nlm.nih.gov/pubmed/23524927    Cuddy et. al. "Evaluating Validity Evidence for USMLE Step 2 Clinical Skills Data Gathering and Data Interpretation Scores: Does Performance Predict History-Taking and Physical Examination Ratings for First-Year Internal Medicine Residents?". https://www.ncbi.nlm.nih.gov/pubmed/26397703    Lehman and Guercio "The Step 2 Clinical Skills Exam: A Poor Value Proposition". https://www.nejm.org/doi/10.1056/NEJMp1213760?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dwww.ncbi.nlm.nih.gov    Guest Contact Information:  Hillary's Email: hillary-johnson@uiowa.edu  Deland's Email: deland.weyrauch@yale.edu  James's Email: jsprice@mcw.edu   Hilary's Biography: Dr. Johnson received a Bachelor of Science degree in microbiology with Highest Honors at the University of Iowa and then completed her medical education and doctorate in immunology at Washington University School of Medicine in St. Louis. After her research on the molecular pathways immune cells use to fight cancer, Dr. Johnson decided to focus on patients with a high risk of developing skin cancer. Following an internship in internal medicine in Boston and training in dermatology at the New York University School of Medicine, she completed a two-year fellowship in Mohs micrographic surgery and procedural dermatology at the Columbia University School of Physicians and Surgeons/New York-Presbyterian Hospital. While in training, she initiated one of the first research projects assessing patient safety and quality of care in the field of dermatology. Dr. Johnson's collective research interests in cutaneous oncology, surgical reconstruction, and patient safety continue to grow. She is a published author of several peer-reviewed journal articles and book chapters, and is a frequent lecturer at universities and national meetings of multiple medical specialty associations.   Deland's Biography:  Deland Weyrauch is a pathology resident at Yale University and Yale New Haven Hospital in New Haven, CT. He received his Doctorate of Medicine from University of North Dakota in Grand Forks, ND. He is from Ray, ND. Deland was successful in passing a resolution through the North Dakota Medical Association to advocate for the elimination of the USMLE Step 2 CS from state licensure requirements for physicians.     Jame's Biography: James Price is a 4th year medical student at Medical College of Wisconsin-Milwaukee. He discovered an immediate interest in health care policy upon starting medical school and has been an active member of the American Medical Association-Medical Student Section, the Wisconsin Medical Society, and the Benjamin Rush Institute. His career goals include increasing access to health care and prioritizing preventative health. He plans to practice Psychiatry and advocate for increased child and adolescent mental health resources  

Many thanks to Chris LeMond, TheHarmonicPulse, SAMUCA CHIODINI, Jim Haugland, Denis, bj7xtas1, thebudsofmay, Zippy Leroux, user name, Yhoda, Joe Turgeon and Daniel Proctor for your insightful questions! :14 What's the deal with Fanned Frets? Also, how does an understand of physics relate to music? 2:23 Is Synesthesia real, or just some BS you made up? 5:11 What is the function of the Fm7 in the chorus to Sir Duke by Stevie Wonder? 8:08 How do you come up with melodies? 10:06 How do you keep so relaxed with your technique on bass? 12:02 What are your thoughts on NOT recording to a click in a modern DAW environment? 14:01 On modern jazz big band music 14:09 How do you approach memorizing large amounts of music? 15:01 Can Adam submit a song for US to review? 15:11 HOW MUCH DID THE 440 CONSPIRACY PAY YOU TO MAKE THE ANTI-432 VIDEO?!?! 15:48 Can I get away with not doubling if I'm a woodwind player looking to make a career in NYC? 17:21 How do I start a career in TEACHING music?   SYNESTHESIA RESEARCH (Cognitive Neuroscience) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037840/ (Journal of Cognitive Neuroscience) http://www.mitpressjournals.org/doi/abs/10.1162/jocn.2010.21486?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed& http://cogprints.org/6268/1/Cortex_sound-colour_Synaesthesia.pdf (Yale journal of biology and medicine) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670440/ (Biological Psychiatry) http://www.biologicalpsychiatryjournal.com/article/S0006-3223(99)00056-6/fulltext (Neuropsychologia) http://www.sciencedirect.com/science/article/pii/S0028393212003879?via%3Dihub (Consciousness and Cognition) http://www.sciencedirect.com/science/article/pii/S1053810013000834 (Neuron) http://www.cell.com/neuron/fulltext/S0896-6273(05)00835-4 Psychology of Music http://mobile.www.daysyn.com/Rogers1987.pdf American Journal of Psychology https://www.jstor.org/stable/1410812?seq=1#page_scan_tab_contents (Others) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134456 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126805/ https://www.ncbi.nlm.nih.gov/pubmed/23000109 SUPPORT ME ON PATREON 
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  We have a strong show for you today . . . we talk about Efferent Copy and motor learning, ankle instability from a neurologic perspective, shoe wear, head tilt and the neurologic and functional complications. -Other Gait Guys stuffB. iTunes link:https://itunes.apple.com/us/podcast/the-gait-guys-podcast/id559864138C. Gait Guys online /download store (National Shoe Fit Certification & more !) http://store.payloadz.com/results/results.aspx?m=80204D. other web based Gait Guys lectures:Monthly lectures at : www.onlinece.com type in Dr. Waerlop or Dr. Allen, ”Biomechanics”-Our Book: Pedographs and Gait Analysis and Clinical Case StudiesElectronic copies available here:-Amazon/Kindle:http://www.amazon.com/Pedographs-Gait-Analysis-Clinical-Studies-ebook/dp/B00AC18M3E-Barnes and Noble / Nook Reader:http://www.barnesandnoble.com/w/pedographs-and-gait-analysis-ivo-waerlop-and-shawn-allen/1112754833?ean=9781466953895https://itunes.apple.com/us/book/pedographs-and-gait-analysis/id554516085?mt=11-Hardcopy available from our publisher:http://bookstore.trafford.com/Products/SKU-000155825/Pedographs-and-Gait-Analysis.aspxShow notes:Human exoskeletons: The Eksohttp://www.thedailybeast.com/articles/2015/08/03/the-mechanical-exoskeleton-shaping-the-future-of-health-care.htmlAnkle muscle strength influence on muscle activation during dynamic and static ankle training modalitieshttp://www.tandfonline.com/doi/abs/10.1080/02640414.2015.1072640?rfr_id=ori%3Arid%3Acrossref.org&url_ver=Z39.88-2003&rfr_dat=cr_pub%3Dpubmed&#.VcYWR-1VhBcChronic ankle instability:http://tmblr.co/ZrRYjx1akudcmhttp://tmblr.co/ZrRYjx1ah6ThVhttp://thegaitguys.tumblr.com/post/68785250796/just-because-a-muscle-tests-weak-doesnt-mean-ithttp://thegaitguys.tumblr.com/post/117109093439/last-week-we-ran-an-archived-piece-named-justthe future of footwear and orthotics ? http://lermagazine.com/special-section/conference-coverage/the-future-of-footwear-and-orthoses-is-here-now-whatsquats- head posture-gait vision-gravityhttp://thegaitguys.tumblr.com/search/vision Music: brain rhythmhttp://www.kurzweilai.net/the-brains-got-rhythm