Podcasts about new drugs

This podcast explores how the federal government is attempting to lower prescription drug prices by examining the newest most-favored nation-focused drug pricing models, including TrumpRx and the GLOBE and GUARD mandatory models. We discuss how each model is structured and its potential impacts on patients, the healthcare system, and the pharmacy workforce. The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.

Can AI move from predicting proteins to actually designing new drugs? Isomorphic Labs is trying to answer one of the biggest questions in science.In this episode of The Neuron, Corey Noles and Grant Harvey talk with Rebecca Paul, Head of Medicinal Drug Design at Isomorphic Labs, and Michael Schaarschmidt, Foundational AI Research Lead.They explain why drug discovery is so slow, expensive, and failure-prone—and why AI drug design is much more complicated than “generate a molecule and ship it.” The conversation covers AlphaFold, structure prediction, molecule generation, binding models, clinical failure rates, human trust in AI systems, and the long-term hope of designing drugs for targets once considered “undruggable.”In this episode:Why drug discovery can take more than a decadeWhat people misunderstand about “AI-designed drugs”How medicinal chemists actually use AI modelsWhy biology is harder than text, images, or codeWhat it would take to make drug discovery faster and cheaperThe dream of designing a drug candidate in one iterationWhy “undruggable” proteins may not stay undruggable foreverAdditional resources:Technical report blog Best resource for learning about the capabilities that we are buildingIsomorphic Labs websiteBest destination for learning more about Iso and joining our team in London, Lausanne or Cambridge, MASubscribe for more grounded conversations on how AI is changing science, work, and the world.For more practical, grounded conversations on AI systems that actually work, subscribe to The Neuron newsletter at https://theneuron.ai.

Learn about the latest in local public affairs in about the time it takes for a coffee break! Brian Callanan of Seattle Channel and David Kroman of the Seattle Times discuss what's next after calls from multiple elected officials to shut down KCRHA, the King County Regional Homelessness Authority. Brian and David also break down the Seattle City Council's work on expanding city-sanctioned homeless encampment capacity, a new report on the efficacy of Seattle's 2023 drug possession law, a study of Seattle's efforts to raise the minimum wage for app-based delivery drivers, and new data about the pedestrianization of Pike Place Market. If you like this podcast, please support it on Patreon!This episode of Seattle News, Views & Brews is presented by Phillips Law Firm. Injured? Their Seattle personal injury lawyers will fight for what you really deserve. 

Medicine is something that everyone's vitally interested in. I have anecdotal proof every time I get something. For instance, when I was just in the UK, I was supposed to speak at an event called Rise. It was on Friday, Saturday, Sunday, and Monday. I didn't speak on Saturday or Sunday; only a little bit on Monday. The last sound that came from my mouth was on Friday night, and the next morning, I couldn't say a word. My voice was locked up. For over two days due to the very kind-hearted nature of devotees, I had a little shelf in my hotel room with no less than twelve different kinds of medicine that were run up. Everybody said, "You take this; it'll knock it out in an hour." Of course, I'm never ever sure—if I take all of them—if it was a combination, or one of the other combinations or permutations, or if it was none at all and I just would have got better myself anyway. But the idea of medicine—auṣadhi or rasāyana—is very appealing. The root word of medicine, med, is Latin; it means "to take appropriate measures." Everyone feels that if I can just adjust a little bit, if I just have the right kind of "goop," then maybe I'll feel better about myself. Some people take analgesics to the extreme because they feel it's really hard to feel good in this world, so they take chemical substances to feel better all the time. But then that doesn't work out because there's a limit to how much you can take; and then you don't get the same effect, and after a while, you just become addicted to it. So, this is a conundrum. In the 1980s, there was a famous musician from San Francisco—so I could talk about him—his name was Huey Lewis. Huey wrote some famous songs. We met Huey once while we were waiting in line for an airplane. Unfortunately, he got a disease where he couldn't hear properly, so he can't sing anymore. But in his day, he wrote many hit songs, and one of them was entitled, "I Need a New Drug." In the song, the lyrics bemoan the fact that there are all these different kinds of cures and drugs—mostly drugs that have severe side effects. The kinds of advertisements we see for pharmaceuticals these days, even though there are billions of dollars put into the research, always have a disclaimer and a warning at the end. In fact, if it's a 60-second advertisement, 10 seconds talks about how good you're going to look after you take this, and the next 50 seconds is about how you might have bleeding ulcers from it and it could cause death. This is a problem. 'Duḥkhauṣadham tad api duḥkham atad-dhiyāham.' Prahlāda Mahārāja says the medicine you get here in the material world is often worse than the disease itself. But in taking the rasāyana-kathā—the topics about Kṛṣṇa—into the ear, it very gently enters the heart. satāṁ prasaṅgām mama vīrya-saṁvido bhavanti hṛt-karṇa-rasāyanāḥ kathāḥ Hṛt means the heart and karṇa means the ear. So you take the medicine here (the ear) and it ends up here (the heart). Taj-joṣaṇād āśv apavarga-vartmani—this means that very quickly, you're going to be on a different path in life. ------------------------------------------------------------ To connect with His Grace Vaiśeṣika Dāsa, please visit https://www.fanthespark.com/next-steps/ask-vaisesika-dasa/?utm_source=youtube&utm_medium=video&utm_campaign=launch2025 https://vaisesikadasayatra.blogspot.com/ ------------------------------------------------------------ Add to your wisdom literature collection: https://iskconsv.com/book-store/?utm_source=youtube&utm_medium=video&utm_campaign=launch2025 https://www.bbtacademic.com/books/?utm_source=youtube&utm_medium=video&utm_campaign=launch2025 https://thefourquestionsbook.com/?utm_source=youtube&utm_medium=video&utm_campaign=launch2025 ------------------------------------------------------------

On the DeRush-Hour Jason runs down some of the top headlines you may have missed. Then he goes "In Depth" Jamie Eskuri, MD, Gillette Children's pediatric neurologist, about a drug trial that may have major implications for kids with a particular form of muscular dystrophy.

Why Isn't TEAM More Popular? Why Do So Many Therapists Resist TEAM CBT? Featuring Matt May, MD Why has the therapeutic community been so resistant to TEAM? This topic has been a concern to me or many years. To be honest, it isn't new. From the very start of cognitive therapy, when I was first learning it, I began modifying it to make it more dynamic, powerful, and effective. But to be honest, I ran into a small (at the time) of Beck loyalists who branded me as an "outsider," something Beck also did when my book, Feeling Good, began to sell and gain popularity. This saddened and frustrated me, and still does, but it had some great spin-off. On my own, my ideas and approaches grew rapidly, and there was no scarcity of young therapists who wanted to work with me.  Below, you will ready Matt's take on why TEAM CBT has not caught on better, followed by my own thoughts. So read, and enjoy, and feel free to share your own thinking on this topic!  On the live podcast, you will hear our lively discussion with our beloved and brilliant host, Rhonda! Thanks for listening today!  Matt, Rhonda, and David Matt's take: Hi David, I'm excited to discuss this topic!  Also, I agree we would be hard-pressed to cover it in an hour, which I believe is the goal for the podcast. So, why isn't TEAM isn't more popular?  My short answer is that TEAM isn't more popular because many therapists don't want to learn it. Those reasons will vary from one person to another and relate to concepts in the model, itself, like 'process resistance' and 'outcome resistance'. While biological factors, like deficits in cognitive flexibility and neuroplasticity, the 'primacy effect' and age-related changes in the brain, combined with the complexity of the TEAM model, will make it near-impossible for some folks to learn it, these barriers are hard to address with our current technology For the purpose of this conversation, it probably makes more sense to consider the psychological barriers therapists have to adopting a model that is scientifically proven to be superior to other approaches.  As a proponent of TEAM and an instructor, I'd love to know what I'm doing wrong, in presenting the model and how to get more people excited about learning it.  While more research would help us see the problem more clearly, here are some factors that likely play a role: It seems humans have a hard time adopting new truths, regardless of the field being considered. I believe it was Schopenhauer who said all new truths go through three phases on the way to acceptance:  People will ridicule it, violently oppose it, then say they knew it all along as self-evident! One cause of this is something called the 'primacy effect'. People preferentially retain the first version of a story they hear.  If that information is corrected, later, they will continue to believe the first version they heard.  Biological Factors play a role in learning, including genetics, aging, illness and toxic exposure. 'Switching gears', mentally, is more challenging in people with Schizophrenia and their first-degree relatives, for example.  We know that neuroplasticity is greatest in our youth and declines over our lifespan.  Hence the importance of early education and attending to our overall health, habits, nutrition and medical care.       Socioeconomic and Cultural factors certainly play a role.  This is well documented in the book, 'The Emperor's New Drugs', showing how marketing prevailed over science in promoting "antidepressants".  Many therapists in training tell me, 'oh, they wouldn't let me use a measurement tool where I work'.   Lack of 'Critical Thinking'. What people believe often has nothing to do with what is evidence-based or logical.  Many people reject global warming despite the evidence and prefer to believe in conspiracy theories.  We tend to preferentially believe what someone says if we feel a kinship or loyalty to that person or view them as an 'expert'. People might believe RFK Jr. when he says immunizations are dangerous, for example, because he is in their political party and in a position of power, rather than review the science for themselves. Sunk-Cost Fallacy:  People who have gone through training may have a sense that they have invested too much time and money in their education to discard that model and start afresh. Even if we covered this in just a few minutes, we'd still be up against the hardest part of TEAM to learn, Agenda Setting.   Lots of 'Good Reasons' NOT to have open hands, explore topics paradoxically, and reasons this is challenging, technically. So, yeah, we'll have a lot to discuss and I'm looking forward to that! Sincerely, Matt Here is David's list Taking a page out of your book, Matt, our field is filled with so-called "schools" of therapy that function much like cults, most with a narcissistic "leader" at the helm. In a cult, members are required to be absolutely loyal, and to believe in claims the guru makes that have little or no evidence to back them up. For example, most "schools" of therapy claim to know "the" cause of emotional distress, when the causes of depression and other forms of emotional disturbance are still not known. What I have been suggesting is that we get rid of all the schools of therapy and usher in a new era of science-based, data-driven therapy, which would amount to a revolution in our field. This idea, which I feel passionate about, always meets with stiff and hostel opposition / push back. People just don't want to hear it. TEAM integrates high-level empathy and compassion with firm accountability. Give Stanford story with Sunny Choi, and the statement that "Stanford graduate students and faculty cannot be held accountable for doing psychotherapy homework. The need insight-oriented therapy!" This angrily issued statement conveyed, actually, two cult-like (to my thinking) components: First, we KNOW that patients should not be asked to do psychotherapy homework between sessions. Second, we KNOW that "insight-oriented therapy" is the treatment, without ever evaluating them. TEAM focuses on the here and now, and emphasize a "fractal" approach to treatment, where the same distortions and self-defeating beliefs will be embedded in the patient's negative thoughts and feelings every time she or he is upset. So, when you change the present, you have already changed the past. Whereas most therapies have traditionally (and still) focus on the past, thinking they will find the cause of the patient's distress in some pattern or traumatic event. TEAM focuses on rapid change in the here and now, where as many (most?) therapies focus on talk therapy that unfolds slowly, over a period of months, years, or even more. This DOES provide a powerful financial incentive to do "talk therapy," since this drastically provides financial security and reduces the incredible pressure of constantly have to find new patients. TEAM is very challenging to learn. I have taught over 50,000 therapists in the past 35 years or more, through my supervision of graduate students and psychiatric residents, my weekly training group at Stanford, and my workshops, including intensive, around the US and Canada. And one lesson that has emerged is just how difficult it is to learn TEAM. It requires a high level of intelligence and aptitude, and an unusual dedication and commitment. A great many of the most important tools, like Assessment of Resistance, and Externalization of Voices with the CAT, Self-Defense, and the Acceptance Paradox, are extremely difficult to learn and master.  And most give up, and drop out, in favor of some simpler and more formulaic therapy that is easy to learn. TEAM training requires constant role-playing with specific and immediate feedback on your performance, which includes bot a letter grade (A, B, C, etc.) as well as what you did that was effective, and where you fell short and might need to fine-tune your technique with frequent role reversals, always with feedback. This means lots of criticism along the way, which many (most?) therapists do not like. And although we repeatedly emphasize the philosophy of "joyous failure," and "learning through failure," most people do not buy it emotionally. We all want success and compliments! And NOT the "great death" of the self." The "great death" permeates every phase of the T E A M process. At the T = Testing, you will nearly always learn that your perceptions of your patients feel, and how they feel about you, are way off base. This is critically important, but painful for most, as it is a direct body blow to our "need" to be in the role of "expert." Unlike most other forms of therapy, we require therapists to measure patients' feelings, "in the here and now," at the start and end of every therapy session, using brief, highly reliable scales that assess feelings of depression, suicidal urges, anxiety, anger, and also happiness, as well as relationship satisfaction or discord. These scales function like an "emotional X-ray machine," allowing therapists for the first time to see exactly how effective or ineffective you were in every therapy session. Can you take it? On the positive side, this information will allow you to fine tune the therapy and learn from all of your patients every day. On the negative side, you may not want to have to "see" your failures before your eyes at every session with every patient. David: Tell the story of Tuesday group patient who proudly showed me her depression (and other scores) over the previous year with one of her patients. . . But there was absolutely no improvement in any scale. This was shocking and it made me very sad. My goal is to get dramatic changes within a single session. This "great death" continues during the E phase. TEAM therapists are required to ask "What's my grade on empathy" during the session, and also patients fill out the Empathy Scale and other scales on the "Patient's Evaluation of Therapy Session" right after the session. These scales are set up to make therapist failure common, almost universal at first. A warm and curious dialogue about where the therapist went wrong can revolutionize the therapy and deepen the relationship—quickly. But at what cost to the fragile ego of the insecure shrink? The "great death" continues with A = Paradoxical Agenda Setting. You give up your role as the "expert:" or "helper" or "rescuer," which many therapist refuse to do, and instead "become" the patient's subconscious resistance, arguing, with compassion and logic, that there are many GOOD reasons NOT to change. This freaks therapists out! The "great death" continues with the M = Methods phase of the session. I have developed roughly 140 methods to help people challenge distorted negative thoughts and self-defeating beliefs, and have always taught that no one method will work for everyone who's depressed and anxious. So you will have to try many methods, using the Recovery Circle, to find the one that works for each patient. But these methods are challenging to learn, and most therapists don't seem to have the intelligence, aptitude, or commitment to learning how to use them. Many of the methods and insights of TEAM or subtle nuances that many therapists do not "get" or perhaps do not want to "get." Example, the ACT training group, where someone held up the Feeling Good book and said, "We do not want THIS!" They falsely believed that "leaning into" your feelings is always the answer, and wrong believed that TEAM tried to make people happy all the time—called Toxic Positivity—whereas nothing could be further from the truth. In fact, I mentioned healthy negative feelings as early as, I think, Chapter 3 in Feeling Good, "Sadness is Not Depression," where I told the story of an elderly man who died on the Stanford inpatient medical service one evening when I was a medical student. Much of what I teach is shocking and at odds with what people are taught in graduate school. For example, the idea that most people with depression and anxiety—NOT everybody!—can be effectively treated in a single, extended therapy session. Curses! That sounds horrible! And even worse-sounding is the idea that change typically happens suddenly, at the very moment patients stop believing their distorted thoughts. Of course, since most therapists have not seen these phenomena, due perhaps to not having the skill, they insist instead that David is some type of fool, liar, or con artis. Okee Dokee! People—therapists and patients alike—do not "get" a great many of the key ideas in TEAM. For example, let's say the socially anxious patient totally believes the thought, "I shouldn't be so screwed up!" the necessary and sufficient conditions for emotional change. The necessary condition: The Positive Thought (PT) must be 100% true. Rationalizations and half-truths have never helped anybody. The sufficient condition: The PT must drastically reduce your belief in the negative thought. And that's when your negative thoughts will suddenly change. There is even more of what I teach is shocking and at odds with what people believe. For example, 2,000 years ago Epictetus stated they key premise of all the cognitive therapies: "People are disturbed, not by things, or events, but by the views they have of them". And recently, our research team has provided proof of this for the first time, in a study of nearly 7,000 users of our Feeling Great app, using sophisticated statistical modeling techniques. So, the three tenants of cognitive therapies, including TEAM, are: First, you FEEL the way you THINK. In other words, all of your positive and negative feelings result from your thoughts in the here-and-now. Second, depression and anxiety are the world's oldest cons. In other words, your negative thoughts, like "I'm not as good as I should be," or "I'm a hopeless case,"—will be loaded with many of the ten cognitive distortions and are extremely misleading—but you don't realize this when you're upset. You will believe these thoughts with all your heart and feel CERTAIN that they are 100% true. Third, you can CHANGE the way you FEEL. But lots of people will won't have it. They keep insisting on theories that simply aren't true—that emotions cause thoughts, for example—and on methods that may have little or no "punch" above and beyond the placebo effect. Story of Tuesday group student who was scolded in her graduate school counseling program for using the words "thought" or cognition during a therapy session. She was told ONLY to focus on feelings. Many people—therapists and patients alike—strongly believe that therapist empathy is THE key to healing. I have developed many powerful empathy tracking and training methods, but our clinical experience and research has shown, over and over, that therapist empathy is NOT the key to healing. They keys involve using TEAM systematically, and the rapid healing happens during the A and M for the most part. But those are the hard parts! Other problems include the idea that we can convert normal human emotional distress into a series of "mental disorders" that are listed in the DSM, the "bible" of the American Psychiatric Association. In TEAM, we consider each patient's patterns of suffering at the start of therapy, quickly and easily screened by the EASY Diagnostic System, but monitor therapy and patient progress with simple tools that measure feelings, like depression, anxiety, anger, and more. But this is an argument for another day. There's a lot more issues, too. Have I, David, contributed to the resistance to TEAM? Absolutely I have. I plead guilty as accused, and I'm proud of it. I'm totally aware that people—maybe even you— get turned off by criticism, and naturally recoil to protect your "in group," as Matt so clearly pointed out, and maintain loyalty to your "leader," whether it's Freud, Jung, Beck, Hayes, Rogers, or whoever. People are more emotional than rational, and people can be intentionally cruel and deceptive, too, all in the name of what they believe. We see that in our politics these days too. People believe things that are totally false, and wildly implausible, because the group or leader says it's true, it's the way things are. I'm a strong believer that science and truth will win out in the long run. Is this inevitable? I'm not totally confident, and have my doubts, but I am also filled with hope, and look to a future with more therapists like our beloved Matt May, MD and others who have dared to venture in a radically new direction, much like the early astronomers like Galileo and Copernicus who dared to challenge the superstitious teachings of the Catholic church. Those brave and brilliant early souls said, "things are NOT the way you think!" And they used data and mathematical modeling to prove their points. But there were a hundreds years of intimidation and suffering until people finally began to catch on to the then-ridiculous and outrageous ideas that the sun does NOT actually revolve around the earth, and that the earth is NOT the center of the universe. Those NOTS changed history. Can it happen again in the fields of psychiatry and psychotherapy? I hope so, and I've been giving my all, in my teaching, research, clinical work and writing, to make this happen. Sadly, I've fallen far short of my dream, but I'm thankful every day for what I've got, and the wonderful colleagues I'm privileged to know and love. Warmly, David, Matt and Rhonda

First up on the podcast, a new path to calculating the Hubble constant. This value for the universe's speed of expansion is typically determined in one of two ways, one favored by cosmologists, the other by astronomers. But the resulting values from these methods are consistently different. Staff Writer Daniel Clery joins host Sarah Crespi to discuss how reappearing bursts from deep space, lensed by gravity, could resolve the dispute over the speed of the expanding universe. Next on the show, freelance producer Elah Feder talks with Mauro Costa-Mattioli, principal investigator at Altos Labs' Institutes of Science, about tuning the “integrated stress response” (ISR) in mouse brains. The ISR pathway turns off much of protein synthesis in cells as a response to stressors such as viral infections or oxygen deprivation. The ISR is overactive in some models of cognitive dysfunction—suggesting the downregulated protein synthesis may hamper brain functions such as memory formation. In his paper, Costa-Mattioli and colleagues show turning on the ISR pathway causes memory problems in mice and turning off the ISR can restore function in mouse models of Alzheimer's disease and Down syndrome. Although this research was in mice, it suggests cognitive dysfunction associated with many different disorders may involve the ISR—making it a good therapeutic target. This week's episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, a new path to calculating the Hubble constant. This value for the universe's speed of expansion is typically determined in one of two ways, one favored by cosmologists, the other by astronomers. But the resulting values from these methods are consistently different. Staff Writer Daniel Clery joins host Sarah Crespi to discuss how reappearing bursts from deep space, lensed by gravity, could resolve the dispute over the speed of the expanding universe. Next on the show, freelance producer Elah Feder talks with Mauro Costa-Mattioli, principal investigator at Altos Labs' Institutes of Science, about tuning the “integrated stress response” (ISR) in mouse brains. The ISR pathway turns off much of protein synthesis in cells as a response to stressors such as viral infections or oxygen deprivation. The ISR is overactive in some models of cognitive dysfunction—suggesting the downregulated protein synthesis may hamper brain functions such as memory formation. In his paper, Costa-Mattioli and colleagues show turning on the ISR pathway causes memory problems in mice and turning off the ISR can restore function in mouse models of Alzheimer's disease and Down syndrome. Although this research was in mice, it suggests cognitive dysfunction associated with many different disorders may involve the ISR—making it a good therapeutic target. This week's episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Pornography is one of the most common—and destructive—threats facing marriages today. In this episode, we talk honestly about lust, confession, repentance, and how couples can fight for holiness, healing, and intimacy in their marriage.Discussion Questions:- What boundaries do we currently have in place to guard our marriage from sexual temptation? Are they enough?- What does it look like practically to “make no provision for the flesh” in our home?- How can we create a culture of confession and grace in our marriage?- Who are trusted people or community members we can invite into accountability if needed?Resources- Freedom Starts Today by John Elmore- Your Brain on Porn- Fight the New Drug- Covenant Eyes

Watch the full video version on YouTube: https://youtube.com/@readysetblowpodcast?sub_confirmation=1   Stand up comedian and musical theater enthusiast, Tommy Mitchell is back in studio. The fellas have a hilarious, uncensored and honest chat about Tommy's love of musicals and dance, the current state of US politics, what humans are going to do when AI takes all of our jobs, the new drugs on the streets, drinking with your buddies, new religions and cults, people claiming America is a Christian nation, the rise of prediction markets, insider trading & gambling, and UAPs conspiracies. The crew brings the show home with some wild and funny weekly news.   Every Thursday, the Ready Set Blow Podcast brings you real talk with comedians, actors, musicians, entertainers, entrepreneurs, and fascinating guests from all walks of life. No scripted BS. No playing it safe…Just raw, funny, and authentic conversations you won't hear on your average podcast.   If you enjoy comedy podcasts like Your Mom's House, Flagrant, The Joe Rogan Experience, or Theo Von, you'll love this show.   What We Talk About in This Episode: 00:00  Podcast Intro 01:00  Improv & Musical Theater 10:00  Cynicism & Apathy in Politics 18:00  AI & Mass Unemployment 21:00  New Drugs 29:00  Drinking Buddies 38:00  Religions vs. Cults 50:00  The Hypocrisy of Christian Nationalism 59:00  Gambling, Prediction Market & Insider Trading 1:02:00  UAPs & Other Conspiracies 1:10:00  The Weekly News   New Episodes Every Thursday:

Dr. William Li, physician, scientist, and president of the Angiogenesis Foundation, joins the show to explain how circulation, the gut microbiome, and inflammation shape our risk of heart disease, cancer, and brain disorders. In this conversation, he breaks down surprising discoveries about microplastics, GLP-1 weight-loss drugs, stem cells, and why the health of our blood vessels may be the hidden key to longevity. Dr. Li is also the author of the bestselling book Eat to Beat Disease, where he explores how food can activate the body's natural defense systems.In our conversation we discuss:(0:00) Introduction(1:32) Why Most People Die From Heart, Brain, or Cancer(1:54) The Real Common Denominator: Circulation(2:18) Why Blood Vessels Control Health(2:44) Young People Getting Diseases of Aging(3:24) Why Researchers Are Looking for the “Smoking Gun”(4:34) Chronic Inflammation Explained(6:04) Environmental Causes of Inflammation(8:19) Microplastics From Car Tires(9:15) Pollution, Water Contamination, and Toxins(11:09) Gut Microbiome: Your 39 Trillion Bacteria(12:15) How Gut Bacteria Control Brain, Mood, and Metabolism(13:24) The Firefighter Role of Good Bacteria(14:44) Dysbiosis and Chronic Disease(15:54) The Gut–Brain Connection(16:32) Is the Appendix Actually Important?(18:11) Why Longevity Studies Take Decades(21:24) Anti-Inflammation Insights From Drug Studies(23:40) GLP-1 Drugs and the Weight Loss Revolution(25:15) Why GLP-1 May Protect the Heart(27:18) Should Healthy People Take GLP-1 For Longevity?(29:40) Side Effects of GLP-1 Medications(32:12) The Unknown Long-Term Effects of New Drugs(34:05) Why Longevity Research Is So Hard(36:30) Stem Cells Explained (Stem Cells 101)(39:17) The 70 Million Stem Cells You're Born With(41:24) Why Stem Cells Decline With Age(43:21) The Truth About Stem Cell Clinics(46:14) Foods That Can Mobilize Your Stem Cells(48:42) Microplastics: Easy Ways to Reduce Exposure(53:08) Water Filters and Reverse Osmosis Debate(56:03) Air Quality and Why It Matters For Health(59:03) Meal Timing, Fasting, and Energy(1:02:24) Why Not Eating Can Improve Health(1:05:42) What To Eat For Breakfast(1:09:42) The Future of Personalized Nutrition(1:13:25) Measuring Your Microbiome(1:17:52) The Next Frontier of Health Research(1:20:54) Food Potency and Superfoods(1:24:23) Longevity vs Quality of Life(1:28:09) The Philosophy of Healthy Aging(1:30:48) Where to Follow Dr. William LiLearn more about Dr. William Li here:Website: https://drwilliamli.com/Youtube: https://www.youtube.com/@DrWilliamLiListen to the full episode here:https://youtu.be/Z20c9JqkbTw

WSJM Afternoon News for 03-02-26See omnystudio.com/listener for privacy information.

Support the show:https://www.paypal.me/Truelifepodcast?locale.x=en_USOne on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meetingPSYCHEDELIC COMPOUNDSThat No One Has Made But I Think I Would LoveEpisode Six: THALASSINE-7(7-OH-Mitragynine-DMT Conjugate / Sigma-2 Agonist / Cortistatin Analog)“The compound that puts you in the water. The water that is already in you.”✦Episode SummaryThis episode delivers a haunting, second-person narrative of THALASSINE-7, a purely theoretical psychedelic that doesn't flood you with new visions — it turns up the volume on what your body is already screaming, clears the static of self-protection, and holds you in crystal-clear confrontation with the self at depth.Framed through a father and his nine-year-old daughter's real-time fight against a rip current at Three Tables Beach on Oahu's North Shore, the “trip” becomes an unflinching mirror for overconfidence, the weight of trust, ignoring warning signs, and the difference between survival and wisdom.The Compound (Theoretical Pharmacology)•  Backbone: Modified 7-hydroxymitragynine redirected from opioid receptors to sigma-2 agonism (mitochondrial receptors that govern the cellular “continue or quit” decision — literally apoptosis/survival signaling).•  Psychedelic Link: 5-substituted DMT moiety connected via sulfonyl linker, creating allosteric cross-talk that amplifies whatever signal your nervous system is already broadcasting instead of overlaying new hallucinations.•  Rest Component: Cortistatin-14 analog — the same neuropeptide your brain releases in deep slow-wave sleep — brought into full waking consciousness to quiet hippocampal chatter and deliver profound, low-static rest while you remain completely alert.Net Effect: Complete wakefulness + total removal of narrative armor + inescapable bodily truth = an encounter with reality you cannot file away.Status: 100% theoretical / fever-dream medicinal chemistry. No one has synthesized this. The lessons it forces are very real.The Trip Report: Three Tables Beach, Pupukea, North Shore OahuSetting: Overcast grey morning at the beach named for three flat coral reef tables visible at low tide. Multiple posted signs warn of powerful rip currents, hazardous shorebreak, and past deaths. The father enters the water anyway with his trusting daughter on his back.Key Moments (clinical timestamps from the narrative):•  T+0:00 — Reading the signs… and walking in.•  T+0:22 — The current slams. Sigma-2 receptors light up with the body's primal “continue” verdict.•  T+0:25–0:41 — Arm-over-arm fight; daughter silent, gripping, sixty-two pounds feeling like the entire world.•  T+0:58 — Shore reached. Arms shaking in six inches of water. Pride and reckoning land simultaneously.•  T+1:20 — The compound forces both truths at once: I brought her back and I never should have taken her in.•  T+2:00 — Integration on the sand: You are not the exception. Do the work in calm water before the current changes again.Real Location NoteThree Tables Beach (also called Kalua o Māua) is a real spot between Waimea Bay and Sharks Cove. It offers world-class snorkeling in summer but is notorious for sudden, powerful rip currents and rogue waves, especially October–April. Signs explicitly warn “Deaths have occurred,” “Strong rip currents capable of pulling swimmers far out to sea,” and “Enter at your own risk.” Recent incidents include drownings and rescues. There is no permanent lifeguard tower. Always check conditions and heed every sign.Core Themes & Takeaways•  The universal “gap at the sign” — the split-second where information becomes discomfort and we quietly decide “that doesn't apply to me.”•  Holding both pride in what your body refused to quit and accountability for the unnecessary risk.•  The ocean as the cleanest laboratory: it applies the same physics to everyone regardless of how much you love the person beside you or how strong your story says you are.•  Capacities are not equal — this is physics, not morality. The ethical response is ruthless honesty about where you actually are and deliberate work to close the gap.•  Parenting in action: what you model when the signs are clear echoes louder than any lecture.•  “Go do the work. In calm water. Before the current changes again.”Key Quote“You are not the exception. You are a person who, when the situation became the thing it was always warning you it might become, found out what you are actually made of. And what you are made of was enough. This time.”Synthesist's NotesThe specific conjugate (sulfonyl-linked 7-OH-mitragynine-DMT-cortistatin analog) exists only in speculation, but every piece draws from documented science: sigma-2 receptors in mitochondria, cortistatin's role in deep sleep consolidation, and the well-known potency of 7-hydroxymitragynine. What is not speculative is the psychological target — the moment we read a warning and override it with self-flattery. THALASSINE-7 is the compound that refuses to let you file that discomfort under “confidence” and keeps the gap open until it becomes transformation.Next EpisodeCHRONOGEN — a peptide-psychedelic hybrid that does not alter time perception. It alters time preference. The body begins to want the present with such ferocity that past and future lose their gravitational pull. The calendar has been keeping records of every appointment your future self never received. It is not angry. It is just waiting.✦END OF EPISODE SIXTHALASSINE-7 • Status: Theoretical. The signs were always right.Thank you for listening (or reading). If this episode moved you, sit with the gap at your own signs today. The water is already in you. One on One Video call W/George https://tidycal.com/georgepmonty/60-minute-meetingSupport the show:https://www.paypal.me/Truelifepodcast?locale.x=en_US

Support the show:https://www.paypal.me/Truelifepodcast?locale.x=en_USOne on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meetingThe metal detector isn't checking whether the building is dangerous for you…it's checking if you are dangerous for those inside! Episode Five of Psychedelic Compounds That No One Has Made But I Think I Would Love. DIGNIN: a peptide-tryptamine hybrid that temporarily takes the cortisol offline and asks it, at the molecular level, whether the threat is real or just a habit. Spoiler: it's a habit. You built it. You've been maintaining it for years. You're very good at it. This is the compound that shows you the blueprints. One on One Video call W/George https://tidycal.com/georgepmonty/60-minute-meetingSupport the show:https://www.paypal.me/Truelifepodcast?locale.x=en_US

Listen without ads at www.patreon.com/dopeypodcastToday on Dopey!  We promote Dopeywood 2026 tickets (April 12 at Comedy Store LA with Marc Maron, Bobby Lee, Margaret Cho, Darrell Hammond, Sam Miller, Allie Makovsky, Zach Noe Towers.Tickets For Dopeywood 2026: https://www.showclix.com/event/dopeywood-2026Also if you want free Narcan/fentanyl test strips write us at dopeypodcast@gmail.com  We Read glowing Spotify feedback on the "Yellow Balloon" episode (jam band recovery groups like Much Obliged), including shoutouts to Benji, hippie Earl's gratitude lists/Secret Santa, and defends five-days-a-week Dopey. Shares Dana's email/story: Philly trank/xylazine struggles, listening while using (sad/lonely but less alone), hilarious failed gas station robberies with an oxy coworker (no masks/weapons, polite denials, eventual $300 haul for pills/McDonald's). Then dives into a marathon convo with Bob Forrest (Don't Die podcast, Celebrity Rehab, Thelonious Monster): Bob's anti-device/oligarch rant (Elon Musk/Jeff Bezos/curated feeds as modern Matrix, Bob Marley money quote, fight fake reality, turn off phones, go outside), social media dividing people (Gaza/Pizzagate/Epstein conspiracies as distractions from economic rape), drug market shifts (meth in fentanyl to preserve customers post-Narcan, cocaine resurgence over crazy-making meth, Kratom ubiquity as "non-addictive" supplement denial), modern addicts numbing vs. old-school enhancement, generational hopelessness (kids glued to iPads, no humor/alive feeling), AA tough love vs. today's softness, economic insecurity fearlessness in recovery, personal racism persistence, unity/civility over war, and life's joy in helping addicts. Ends with Mike Martt/Nick Thorpe's "Good So Bad" cover!SEO Search Terms: Suggested Title: Today on Dopey! Wednesday Dose: Bob Forrest Rants Oligarchs/Social Media Matrix, Fentanyl Meth Shifts, Unity Over Division + Nora's Sweet Sober Dad Moment (Valentine's 2026) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dinesh Patel, PhD, CEO of Protagonist Therapeutics, discusses the New Drug Application (NDA) submission to the US Food and Drug Administration (FDA) for rusfertide to treat adults with polycythemia vera (PV).PV is characterized by excess red blood cells in the bloodstream, increasing the risk for blood clots. Most cases of PV are acquired and occur more frequently in men than in women. The condition has been associated with genetic changes in the JAK2 and TET2 genes. Rusfertide is an investigational first-in-class subcutaneously administered hepcidin mimetic peptide designed to regulate iron homeostasis and red blood cell production to control hematocrit levels in patients with PV.The NDA submission is based on positive 32-week primary analysis and 52-week results from the phase 3, global, randomized, placebo-controlled VERIFY clinical trial (NCT05210790). In this study, patients receiving rusfertide plus standard of care therapy demonstrated a substantially higher response rate compared to placebo plus standard of care, including durable hematocrit control, a reduction in phlebotomy requirements and improvement in pre-specified patient reported outcome endpoints.Rusfertide has received Breakthrough Therapy Designation, Orphan Drug Designation, and Fast Track Designation from the FDA.

Support the show:https://www.paypal.me/Truelifepodcast?locale.x=en_USOne on One Video Call W/George https://tidycal.com/georgepmonty/60-minute-meeting═══════════════════════════════════════════════════════════════════PSYCHEDELIC COMPOUNDS THAT NO ONE HAS MADE BUT I THINK I WOULD LOVE═══════════════════════════════════════════════════════════════════EPISODE 02: Ψ-COLLAPSE(3,4-Methylenedioxy-N-Superposition-Amphetamine)"The compound that makes you all possible versions of yourself at once, then forces you to choose which one survives measurement."═══════════════════════════════════════════════════════════════════

The Hidden Lightness with Jimmy Hinton – For years, Americans have paid the highest drug prices on the planet—sometimes more than 1,000 percent higher than what patients pay in other developed nations for the exact same medications. TrumpRx.gov represents an aggressive attempt to bring transparency and accountability to a system long dominated by pharmaceutical giants...

Today, we're diving into an increasingly urgent and complex area of frontline medicine: novel psychoactive substances and synthetic drugs. Over the past decade, the drug landscape has shifted dramatically. Potent synthetics, unpredictable chemical variants, and rapidly evolving supply chains are creating new clinical challenges for ambulance crews, HEMS teams, and frontline responders. These substances don't play by traditional rules; presentations can be extreme, toxidromes atypical, and responses to treatment unpredictable. To help us understand this shifting landscape, I'm joined byDr Caroline Copeland, Senior Lecturer in Pharmacology and Toxicology at King's College London and Director of the National Programme on Substance Use Mortality. Caroline is one of the UK's leading experts in drug-related harms, combining pharmacology, epidemiology, and innovative data science to better understand emerging substances and their real-world impact. She advises national bodies, contributes to the ACMD's Novel Psychoactive Substances Committee, and leads national surveillance programmes shaping policy and practice. Today, she helps us unpack what clinicians need to know, what's changing, and how we can better protect patients in a rapidly evolving drug landscape. Caroline's work and publications can be found here: https://www.kcl.ac.uk/people/caroline-copelandThis episode is sponsored by PAX: The gold standard in emergency response bags.When you're working under pressure, your kit needs to be dependable, tough, and intuitive. That's exactly what you get with PAX. Every bag is handcrafted by expert tailors who understand the demands of pre-hospital care. From the high-tech, skin-friendly, and environmentally responsible materials to the cutting-edge welding process that reduces seams and makes cleaning easier, PAX puts performance first. They've partnered with 3M to perfect reflective surfaces for better visibility, and the bright grey interior makes finding gear fast and effortless, even in low light. With over 200 designs, PAX bags are made to suit your role, needs, and environment. And thanks to their modular system, many bags work seamlessly together, no matter the setup.PAX doesn't chase trends. Their designs stay consistent, so once you know one, you know them all. And if your bag ever takes a beating? Their in-house repair team will bring it back to life.PAX – built to perform, made to last.Learn more at ⁠https://www.pax-bags.com/en/⁠

AP's Lisa Dwyer reports on new negotiations on Medicare drug pricing.

In episode #97 of “The Weekly Bioanalysis” podcast, John and Dom focus on a review of 2025 drug approvals, revealing a surprisingly strong year for small molecules despite long-standing predictions of their decline. Of the 53 FDA approvals, 31 were small molecules, with additional complexity coming from ADCs and RNAi therapies, underscoring the continued importance of small-molecule development and analytics. The hosts also compare U.S. and European approvals, noting meaningful differences driven by regulatory timing and regional priorities rather than scientific divergence. They highlight encouraging momentum in ADCs, the role of acquisitions in successful approvals, and a broad mix of indications—from rare diseases and oncology to neurology and vaccines. Overall, the episode reinforces that innovation remains diverse, with small molecules, large molecules, and conjugated technologies all playing critical roles in modern drug development. If you want a comprehensive view of the noteworthy approvals from 2025, this is the episode you're looking for!“The Weekly Bioanalysis” is a podcast dedicated to discussing bioanalytical news, tools and services related to the pharmaceutical, biopharmaceutical and biomarker industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Senior Scientific Advisors as they chat over coffee and discuss what they've learned about the bioanalytical world the past couple of weeks. “The Weekly Bioanalysis” is brought to you by KCAS Bio.KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.

Contributing writer Jake Fogleman and I break down last week's oral arguments in Wolford v. Lopez, which saw a majority of the Supreme Court justices express skepticism toward the legality of Hawaii's "Vampire Rule" gun carry law. We also talk about the ATF's new proposal to redefine who counts as an "unlawful drug user" for the purposes of federal gun law.

About this episode: Medetomidine, a veterinary sedative similar to xylazine, is appearing more frequently in drug supplies in Maryland, Delaware, and Pennsylvania—and the withdrawal symptoms are debilitating. In this episode: Addiction medicine specialist Jordan Nahas-Vigon details the risks facing people who use drugs and why it's so difficult to quit. Guests: Dr. Jordan Nahas-Vigon is a primary care doctor with Johns Hopkins Medicine who specializes in addiction medicine. Host: Dr. Josh Sharfstein is distinguished professor of the practice in Health Policy and Management, a pediatrician, and former secretary of Maryland's Health Department. Show links and related content: A Powerful New Drug Is Creating a 'Withdrawal Crisis' in Philadelphia—New York Times Why the animal sedative behind a Baltimore mass overdose is so hard to quit—The Baltimore Banner Sedative 'dex' is replacing 'tranq' in illegal drug supply and causing excruciating withdrawal—STAT The Xylazine Crisis—Public Health On Call (May 2023) Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌PublicHealthPod on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.

Dr. Santina Wheat, Program Director, McGaw Northwestern Family Medicine Residency Northwestern Medicine, Delnor Hospital, joins Dean Richards for this week's health update. They talk about the development of a drug to combat Alzheimer’s and ALS and give an update on the super flu.

Send us a textIn this episode of Cannabis Legalization News, host Tom updates viewers on the latest developments in federal cannabis policy, focusing on federal law, administrative choices, and the potential rescheduling of cannabis. The episode features a conversation with a new member, Joshua Potter, and a deep dive into consumer preferences for THC and CBD ratios in cannabis beverages. Tom also discusses the evolving landscape of legal cannabis in the U.S. and the international market's potential impact on legalization. Special guest Aaron Zeman joins from Hawaii to discuss his experiences with activism, legal battles, and the unique challenges of growing cannabis in Hawaii. The show concludes with a segment about the upcoming Hawaii Cannabis Expo and a fun 'Name That Strain' game featuring Relief Botanical's Humboldt Dream.00:00 Introduction and Weekly Overview00:26 Federal Law and Policy Changes01:12 Cannabis Beverage Market Discussion02:50 Rescheduling and Legalization Challenges12:59 Guest Interview: Activism and Legal Battles15:10 Supreme Court and Legal Precedents26:21 International Cannabis Market37:17 Compliance and Regulation in the Cannabis Industry40:58 Supreme Court and Firearms Case41:17 Legal Perspectives on Firearms and Cannabis42:07 Dormant Commerce Clause and Marijuana Commerce44:09 Regulatory Load in the Cannabis Industry46:16 Hawaii Cannabis Expo and Book Signing47:15 Challenges in the Cannabis Industry59:24 Cannabis Industry vs. Cannabis Plant01:02:07 Cannabis Legalization and Market Dynamics01:09:54 Hawaiian Cannabis Strains and Cultivation01:13:50 Closing Remarks and Future ProspectsSupport the showGet our newsletter: https://bit.ly/3VEn9vu

A Holiday tradition like few other. Are we keeping, regifting, or returning new oncology drugs approved in 2025?

Shimer teaches you the 6 scientific roots of your porn use, and gives you practical steps for eradicating them from your life for good. Ted Shimer has mentored men since 1991. He is a Dallas Seminary-trained Pastoral Sex Addiction Professional-Supervisor who helps people overcome the bondage of pornography in the context of making disciples.  Ted is the Founder of The Freedom Fight, an online porn addiction recovery program, and the author of the book, The Freedom Fight, The New Drug and the Truths that Set Us Free, which is our topic for today.  Jim's newest book, Guardrails: Ten Boundaries for an Unbreakable Marriage will be releasing in April 2026. Sign up to be notified when it's available at https://meninthearena.org/guardrails. This episode is sponsored by Compassion International. Our goal is for the Men in the Arena tribe to sponsor 1,000 boys over the coming year! Help us reach that goal and make a difference in a child's life today. When you sponsor a child using our link, you'll receive a free copy of Jim's book, Dialed In: Reaching Your Full Capacity as a Man of God! We are also sponsored by MTNTOUGH Fitness Lab, a Christian-owned fitness app. This app, combined with diet, has helped Jim get in the best shape of his life! Get 6 weeks free with the code ARENA30 at MTNTOUGH.com. Every man needs a locker room. Apply to join an exclusive brotherhood of like-minded men in The Locker Room, our monthly live Zoom Q&A call! We meet in the Locker Room once a month for community, fellowship, laughter, and to help each other find biblical answers to life's difficult questions. Locker Room members also get access to monthly exclusive leadership trainings, historically only available to the staff team at Men in the Arena. Membership is by application only. Go here to apply: https://patreon.com/themeninthearena Get Jim Ramos' USA TODAY Bestselling book, Dialed In: Reaching Your Full Capacity as a Man of God (https://tinyurl.com/dialedinbook)

Hour 3 of the Chris Hand Show | Wednesday 12-17-25See omnystudio.com/listener for privacy information.

A growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research.

We are bringing you some actually good news and a new drug that is showing incredible promise in fighting HIV/AIDS. It's called lenacapavir. It's not available in Canada yet, but it's getting its first real-world test in three African countries. We talk to Dr Darrell Tan, a leading Canadian HIV prevention researcher about the promise of lenacapavir, and why Canadian doctors should be doing more to make sure HIV prevention drugs get to the people who need them most. And Dr Catherine Martin, a senior researcher with Wits Reproductive Health and HIV in Johannesburg.

Today, I want to warn you about a dangerous substance abuse trend which centers around an increasingly popular herbal drug which is available online and in stores, including gas stations and vape shops. Known as Kratom – K-r-a-t-o-m – the drug comes from the tree of the same name that is native to Southeast Asia. Users chew the tree's leaves, brew the leaves, or create a liquid extract. Users who ingest Kratom in low doses report that the effects are like those of a stimulant which increases alertness and energy. When used at higher doses, it works as a sedative to calm one's nerves and anxiety, and to reduce pain. The drug takes effect in minutes with the effects lasting a few hours. The physical side effects are many, and there also side effects on one's brain and nervous system, including hallucinations, and in some cases, death. Our kids are at risk, and we must warn them about the dangerous effects of this and all other drugs. Protect your kids by learning more about Kratom.

On today's episode, Vince sits down with Rob Dyer, former Marine and CIA paramilitary officer, to uncover a $10B gray-market plant product — a potent kratom derivative called 7-hydroxy (7-OH). This compound comes from the kratom leaf and is chemically enhanced to deliver a stronger, opioid-like effect. They break down the CCP's potential role, shadowy companies, and legal loopholes fueling this hidden industry few Americans know about. To purchase Borderland Merch, visit: https://thisisironclad.com/collections/borderland Borderland is an IRONCLAD Original 1stPhorm Go to⁠ ⁠https://www.1stphorm.com/borderland⁠⁠ and get free shipping on any orders over $75, free 30 days in the app for new customers, and 110% money back guarantee on all of our products. DeleteMe Go to https://www.joindeleteme.com/IRONCLAD and use coupon code IRONCLAD, or  scan the QR code TacPack  Visit http://www.TacPack.com  and use code IRONCLAD at checkout to get a free $70 tactical gift   AmmoSquared Visit https://ammosquared.com/ today for a special offer and keep yourself fully stocked. With over 100,000 members and thousands of 5-star ratings, Your readiness is their mission. Learn more about your ad choices. Visit megaphone.fm/adchoices

Joe Pags spotlights the explosive moment in Congress today as Nancy Mace publicly slams Rep. Corey Mills — and you'll understand exactly why he's now facing censure. Then, Rep. Brandon Gill steps up with a bold defense of America First, and Pags asks the obvious question: How is this even controversial in 2025? Finally — why is Ryan Wetting suddenly being labeled the “new drug lord”? Kash Patel and Pam Bondi break it all down, and Pags delivers the straight facts behind the headlines. A fast, fiery, can't-miss hour! Learn more about your ad choices. Visit megaphone.fm/adchoices

LISTEN and SUBSCRIBE on:Apple Podcasts: https://podcasts.apple.com/us/podcast/watchdog-on-wall-street-with-chris-markowski/id570687608 Spotify: https://open.spotify.com/show/2PtgPvJvqc2gkpGIkNMR5i WATCH and SUBSCRIBE on:https://www.youtube.com/@WatchdogOnWallstreet/featured  Cartel violence in Mexico just crossed another terrifying line — a mayor murdered, citizens storming government buildings, and a political climate where critics don't just get silenced… they get buried. With more than 30,000 cartel-related murders a year and American lives being devastated by fentanyl and synthetic opioids flowing across the border, patience is running thin.Now, reports say the Trump administration is quietly preparing potential U.S. special-operations plans inside Mexico — whether as real strategy or pressure tactics to force action from Mexico's government. But will Washington finally get serious about cartel power, or will corporate interests and political cowardice keep the status quo in place?Is this just a warning shot — or the first step toward a new front in the war on drugs?

Three Big Conversations: The new Frankenstein movie hits theaters. -  Deep-dive into the pornography-obsessed subculture known as "gooning,". - Why high-potency marijuana use is landing some users in the ER. -  Song of the Week - "The Fate of Ophelia" - Taylor Swift - Click here for the lyrics. -  Elsewhere in Culture: -  For the first time since 1990, there are no rap songs on the Billboard Top 40—marking the end of a 35-year streak. K-pop sensation BTS will end their three-year hiatus next year, embarking on a tour and releasing new music. A high school teacher went viral with a post on TikTok that showed the extreme way students reacted to his instruction to write a five-sentence paragraph.The as-yet-unidentified jewelry robbers who pulled off a heist at the Louvre were the topic of this week's social media fascination. YouTube is adding more content restrictions to better protect minors from encountering two types of content: online gambling and video games that depict graphic violence.  Check out our Ask Axis episode "How do I talk to my adult son about porn and screen addiction?" Check out Fight the New Drug for teens. Check out Pure Desire for adults. Become a monthly donor today, join the Table. For more Axis resources, go to axis.org.  

Tara unpacks an intense mix of political, economic, and public safety crises in this episode. She exposes alleged surveillance of the entire Republican ecosystem, explores Trump's global strategy to counter China's control over rare earth minerals, and breaks down the rising threat of synthetic opioids like xylazine and nidazines. Tara also examines financial markets, the U.S. economic landscape under tariffs, and controversial funding from organizations like the Gates Foundation tied to China's military. From domestic political battles to international negotiations, this episode covers the high-stakes conflicts shaping America today. Politics, power, and peril—what they're not telling you. Tara provides an exhaustive look at recent political and global developments, beginning with alleged massive surveillance targeting the Republican Party and its affiliates. She examines Trump's ongoing efforts to counter China's economic leverage on rare earth minerals and the deadly new synthetic opioids infiltrating the U.S. She also delves into financial news, including tariffs, inflation, and stock market trends, highlighting how economic manipulations affect everyday Americans. Tara further reveals connections between U.S. funding, the Gates Foundation, and China's military, emphasizing the critical stakes of global trade, public health, and political accountability. This episode blends investigative reporting with analysis of national security, public safety, and political strategy.

The new Frankenstein movie hits theaters, a deep-dive into the pornography-obsessed subculture known as "gooning," and why high-potency marijuana use is landing some users in the ER. Song of the Week - "The Fate of Ophelia" - Taylor Swift Click here for the lyrics. Elsewhere in Culture: For the first time since 1990, there are no rap songs on the Billboard Top 40—marking the end of a 35-year streak. K-pop sensation BTS will end their three-year hiatus next year, embarking on a tour and releasing new music. A high school teacher went viral with a post on TikTok that showed the extreme way students reacted to his instruction to write a five-sentence paragraph.The as-yet-unidentified jewelry robbers who pulled off a heist at the Louvre were the topic of this week's social media fascination. YouTube is adding more content restrictions to better protect minors from encountering two types of content: online gambling and video games that depict graphic violence. Check out our Ask Axis episode "How do I talk to my adult son about porn and screen addiction?" Check out Fight the New Drug for teens. Check out Pure Desire for adults. Become a monthly donor today, join the Table. For more Axis resources, go to axis.org.

America's hospitals will soon face an unprecedented rebate-based prescription drug model, come Jan. 1 – that's when there will be as many as 10 major drugs subject to Medicare price caps. This development is expected to create administrative and financial challenges for hospitals, which will have to pay the commercial price for such drugs while waiting for the rebates.For analysis and context, Maureen Testoni, president and CEO for 340B, will be the special guest during the next live edition of Monitor Monday. She will also review a recent Congressional Budget Office (CBO) report, featured in a recent Senate committee hearing, that includes some misrepresentations about why the 340B program has grown in recent years.As a special bonus, the longtime Internet broadcast produced by RACmonitor, will feature senior healthcare consultant Drew Updike, MD, who will recognize the tireless work being performed by the employees of the U.S. Department of Health and Human Services Office of Inspector General (HHS-OIG) who continue to work despite the federal shutdown, now in its fifth week.The weekly broadcast will also include these instantly recognizable features:Monday Rounds: Ronald Hirsch, MD, vice president of R1 RCM, will be making his Monday Rounds.The RAC Report: Healthcare attorney Knicole Emanuel, partner at the law firm of Nelson Mullins, will report the latest news about auditors.Risky Business: Healthcare attorney David Glaser, shareholder in the law offices of Fredrikson & Byron, will join the broadcast with his trademark segment.Legislative Update: Adam Brenman, senior legislative affairs analyst for Zelis, will report on the news happening at the intersection of healthcare and congressional action.

AI is everywhere these days, and though there's debate about how useful it is, one area where experts think it could be game-changing is scientific research. It promised to be particularly useful for speeding up drug discovery, an expensive and time-consuming process that can take decades. But so far, it hasn't panned out.The few AI-designed drugs that have made it to clinical trials haven't been approved, venture capital investment in these efforts has cratered in the last few years, and many startups have shut their doors. So why has it been so hard to make AI-designed drugs? What are the fundamental issues, and what does the future of this research look like?Joining Host Ira Flatow with some answers is Peter Coveney, who studies how chemistry discoveries can be sped up with algorithms and computers.Guest: Dr. Peter Coveney is a professor and director of the Centre for Computational Science at University College London.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Stocks dropping across the board, as President Trump threatens a tariff increase on China. The sectors getting hit the hardest, and where government layoffs are beginning as the shutdown continues. Plus Another drug pricing deal in the pharma space. The company striking a deal with the President, and the reaction from the health care sector.Fast Money Disclaimer Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Endometriosis is estimated to affect one in ten Kiwi women, it can cause debilitating pain and really affect women's ability to live life to the fullest. But today we saw an exciting headline - the first treatment for endometriosis in nine years is now registered in New Zealand. It's called Ryeqo. Professor Neil Johnson, a gynaecologist from the Auckland Gynaecology Group, former president of the World Endometriosis Society, and an investigator for the international trials of Ryeqo chats to Jesse.

AI science advances are FINALLY happening while OpenAI's Sam Altman & NVIDIA's Jensen Huang send billions back and forth. If $100 billion is a drop in the well, how much do they need? Plus, ChatGPT is causing divorces, new AI video models Kling 2.5 Turbo & Wan 2.5, Suno drops v5 & Gavin drops the fact that he's not *loving* Kevin's mustache. Oh & we're getting ready for the launch of AndThen, our new start up! Sign up now in the link below.   Get notified when AndThen launches: https://andthen.chat/ Come to our Discord to try our Secret Project: https://discord.gg/muD2TYgC8f Join our Patreon: https://www.patreon.com/AIForHumansShow AI For Humans Newsletter: https://aiforhumans.beehiiv.com/ Follow us for more on X @AIForHumansShow Join our TikTok @aiforhumansshow To book us for speaking, please visit our website: https://www.aiforhumans.show/   // Show Links // AI Psychedelics Are Here https://www.wired.com/story/a-startup-used-ai-to-make-a-psychedelic-without-the-trip/ Nvidia to Invest 100b In OpenAI (a lot of which will be spent on Nvidia chips) https://www.cnbc.com/2025/09/22/nvidia-openai-data-center.html “A Hundred Billion Is A Small Dent In It” Sam on CNBC https://x.com/sundeep/status/1970311723262656638 Sam Altman on “Abundant Intelligence” https://blog.samaltman.com/abundant-intelligence How will OpenAI pay for all this? Advertising. https://x.com/alexeheath/status/1970998934278676710 New models incoming that will be more that GPT-5 Pro  https://x.com/sama/status/19698 35407421374910 Meanwhile… ChatGPT is Causing Divorces https://futurism.com/chatgpt-marriages-divorces Suno v5 https://x.com/SunoMusic/status/1970583230807167300 Kevin's Terrible Mustache Https: //suno.com/s/j0b9Ukgd2CbtHVbu Kling 2.5 Is Pretty Good https://x.com/Kling_ai/status/1970439808901362155 Wan 2.5 With Audio https://blog.fal.ai/wan-2-5-preview-is-now-available-on-fal/ Wan Darth Vader https://x.com/fofrAI/status/1970877788384337977 Skild AI Robot Gets Legs Sawed Off & Learns To Walk Again https://x.com/SkildAI/status/1970940614234771579 Unitree's Anti-Gravity Mode https://x.com/UnitreeRobotics/status/1970039940022239491 If Stalin's Life Was A Video Game https://www.reddit.com/r/ChatGPT/comments/1npbwdr/if_they_made_a_video_game_about_the_life_of_stalin/ Carboarding: The Movie https://www.reddit.com/ r/ChatGPT/comments/1nmdipq/carboarding_the_movie/  

Date: Sept 16, 2025 Reference: Prada et al. Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology. Environ Health. August 2025 Guest Skeptic: Dr. Andrew Martin is an emergency physician practicing in Jacksonville, Florida.  Case: A 27-year-old at 24 weeks' gestation presents to the emergency department (ED) with fever (38.6 °C), myalgias, and […] The post SGEM#485: I Want a New Drug – One Not Associated with Neurodevelopmental Disorders first appeared on The Skeptics Guide to Emergency Medicine.

Move over Sinaloa Cartel, there's a new kingpin in town

Is pornography hijacking your child's brain? In this essential episode of Parenting Great Kids with Dr. Meg Meeker, Dr. Meg sits down with Parker Hymas, Director of Public Outreach at Fight The New Drug, to expose the growing threat pornography poses to kids and teens in today's digital-first world.

Under a new proposal, Washington state taxpayers would foot the bill for addicts to get hard drugs. Prepare for sweeping statewide reparations. Congresswoman introduces “housing not handcuffs” bill. Teachers' union trains members on how to obstruct ICE. Elon Musk threatens to derail midterms over Big Beautiful Bill.

Some hugely profitable drugs are targeted under new price controls. Big Pharma has been spending millions to fight them tooth and nail.Order Sharyl's new bestselling book: “Follow the $cience.” Subscribe to my two podcasts: “The Sharyl Attkisson Podcast” and “Full Measure After Hours.” Leave a review, subscribe and share with your friends! Support independent journalism by visiting the new Sharyl Attkisson store.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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