Podcasts about int j mol sci

referencesCell Metab. 2018 Sep 4;28(3):504-515.e7.Int J Mol Sci . 2022 Jul 12;23(14):7697Proc Natl Acad Sci U S A. 2023 Jan30;120(6):e2219630120.Townsend, P.1971 Love Reign o'er Me The Who Quadrapheniahttps://music.youtube.com/watch?v=9PnXts0Ni8I&si=0G6MjcyFJi4MV7wn

ReferencesActa Pharm Sin B. 2022 Dec;12(12):4390-4406Cell Death Discov . 2023 Dec 12;9:451.JBC 1997. Volume 272, Issue 36p22432-22437SeptemberCell Metab. 2012 Jun 6;15(6):813–826.Int J Mol Sci. 2022 May 26;23(11):5978Hayward, J. 1967. "The Afternoon " from: Days of future Passed lp.https://open.spotify.com/track/4uCFK6Lm1gA3MaIbSRhIfS?si=48ccbe6f079e469fMcQuinn, R. 1970. "Pale Blue" Byrds lp :Byrdmaniax.https://open.spotify.com/track/46D9uj48T6E8xlSKLv4cEU?si=495da777c73c4929Mozart, WA. 1788. Divertimento in E flat Major. K 563https://open.spotify.com/album/5yxpvtJJTlKUMtUtl9nBcm?si=zc_K0IlzRqOzVVatZs_Pkw

Eileen Egan, DNP, FNP-C, BC-ADM, CDCES, FADCES joins The Huddle to share her expertise about the interplay between weight and glycemic management in people with Type 2 diabetes, the importance of meeting glycemic and weight goals early after a Type 2 diabetes diagnosis, as well as best practices for helping people stay motivated and engaged. This episode was made possible with support from Lilly, A Medicine Company. Learn more about this topic in this accompanying patient/client handout (support for the development of this handout was provided by Lilly, A Medicine Company): adces_tipsheet_early_control2.pdf References:American Diabetes Association. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of care in diabetes- 2024. Diabetes Care, 47(1): S145-S157.Center for Disease Control and Prevention. Adult overweight and obesity. https://www.cdc.gov/obesity/basics/adult-defining.htmlDCCT/EDIC study research group. Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes: The DCCT/EDIC Study 30-Year Follow-up. Diabetes Care. 2016;39(5):686-693. Gregg E, Jakicic J, Blackburn G, et al. Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post hoc analysis of the Look AHEAD randomized clinical trial. Lancet Diabetes Endocrinol. 2016; 4(11): 913-921.Gutiérrez-Cuevas J, Santos A, Armendariz-Borunda J. Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases. Int J Mol Sci. 2021. 27;22(21):11629.Howard BV, Ruotolo G, Robbins DC. Obesity and dyslipidemia. Endocrinol Metab Clin North Am. 2003;32(4):855-867. Jin X, et al. Pathophysiology of obesity and its associated diseases. Acta Pharm Sin B. 2023;13(6):2403-2424.  Laiteerapong N, Ham SA, Gao Y, et al. The legacy effect in type 2 diabetes: impact of early glycemic control on future complications (The Diabetes & Aging Study). Diabetes Care. 2019;42(3):416-426.Lean MEJ, Leslie WS, Barnes AC, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.Lancet Diabetes Endocrinol. 2019;7(5):344-355.Lingvay I, Sumithran P, Cohen RV, le Roux CW. Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation. Lancet. 2022 Jan 22;399(10322):394-405. doi: 10.1016/S0140-6736(21)01919-X. Epub 2021 Sep 30. Erratum in: Lancet. 2022 Jan 22;399(10322):358. PMID: 34600604Rachel G. Miller, Trevor J. Orchard; Understanding Metabolic Memory: A Tale of Two Studies. Diabetes 1 March 2020; 69 (3): 291–299. https://doi.org/10.2337/db19-0514Ross, R., Neeland, I.J., Yamashita, S. et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol16, 177–189 (2020). https://doi.org/10.1038/s41574-019-0310-7Thom G, McIntosh A, Messow CM, et al. Weight loss-induced increase in fasting ghrelin concentration is a predictor of weight regain: Evidence from the Diabetes Remission Clinical Trial (DiRECT). Diabetes Obes Metab. 2021;(23):711-719.Tsai AG, Bessesen DH. Obesity. Ann Intern Med. 2019;170(5):ITC33-ITC48.Wing RR, Bolin P, Brancati FL, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145-154.World Health Organization. Obesity. https://www.who.int/health-topics/obesity#tab=tab_1 Listen to more episodes of The Huddle at adces.org/perspectives/the-huddle-podcast.Learn more about ADCES and the many benefits of membership at adces.org/join.

In this episode, Trista Chan provides a comprehensive overview of Polycystic Ovary Syndrome (PCOS), discussing its prevalence, causes, symptoms, and the importance of understanding this complex condition. She emphasizes the role of insulin resistance and chronic inflammation in PCOS and explores various treatment options, including medications and lifestyle changes. The episode highlights the significance of nutrition and lifestyle factors in managing PCOS symptoms and improving overall health. Trista also shares insights on the upcoming PCOS recovery program, aimed at empowering individuals to take charge of their health. In this episode, you'll learn: How insulin resistance and inflammation are key features of PCOS Treatment options for PCOS to address metabolic, reproductive, and psychological health Lifestyle changes, meal timing, and tips for adopting a nutrient-dense diet to help alleviate PCOS symptoms Episode Links: PCOS Recovery - Join for February 2025 Reference: Aboeldalyl S, James C, Seyam E, Ibrahim EM, Shawki HE, Amer S. The Role of Chronic Inflammation in Polycystic Ovarian Syndrome-A Systematic Review and Meta-Analysis. Int J Mol Sci. 2021 Mar 8;22(5):2734. doi: 10.3390/ijms22052734. PMID: 33800490; PMCID: PMC7962967. Helena Teede et al. International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2023. Monash University. Juhász, A.E., Stubnya, M.P., Teutsch, B. et al. Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome: a systematic review and network meta-analysis. Reprod Health 21, 28 (2024). Lee I, Cooney LG, Saini S, Sammel MD, Allison KC, Dokras A. Increased odds of disordered eating in polycystic ovary syndrome: a systematic review and meta-analysis. Eat Weight Disord. 2019 Oct;24(5):787-797. doi: 10.1007/s40519-018-0533-y. Epub 2018 Jun 26. PMID: 29947018; PMCID: PMC7918293. Pirotta S, Barillaro M, Brennan L, Grassi A, Jeanes YM, Joham AE, Kulkarni J, Couch LM, Lim SS, Moran LJ. Disordered Eating Behaviours and Eating Disorders in Women in Australia with and without Polycystic Ovary Syndrome: A Cross-Sectional Study. J Clin Med. 2019 Oct 14;8(10):1682. doi: 10.3390/jcm8101682. PMID: 31615157; PMCID: PMC6832459.

References Cell Reports 2015. Volume 13, Issue1p132-144October 06. Discov Immunol. 2024 Nov 19;3(1):kyae016. Cell Metab. 2012 Jun 6;15(6):813–826. Int J Mol Sci. 2023 May 16;24(10):8811 Poulton and Fosdick 1956. "Love Me Tender" Elvis Presley. https://www.youtube.com/watch?v=36GZtwyXqgc Schubert, F. 1828. Symphony #9. in C Major D. "The Great" https://www.youtube.com/watch?v=TPpvJnwf5BU

References Guerra, DJ. 2025. Biochemistry Lectures. Int J Mol Sci. 2023 May 16;24(10):8811. Front Endocrinol (Lausanne). 2020 Dec.3; 11:587189 Berry, Chuck. 1958. "Johnny B Goode". Dead. Winterland 71' https://youtu.be/dWvdY-j0_Kw?si=HhKedcHgHhMOY3Di Brahms, J. 1878. Violin Concerto. D Major. Op 77 https://youtu.be/9L6a-JJCCzw?si=mh8Q_4dKuPWvEfwB

Cuando pensamos en aceites saludables, el aceite de oliva suele llevarse toda la atención. Pero, ¿y el aceite de aguacate? ¿Es tan bueno como dicen?

Early diagnosis and treatment of dental pathologies allows for more conservative treatments while saving patients time and money. When developing the Six Lessons Approach to Biomimetic Dentistry, Dr. David Alleman created a risk assessment for determining if teeth were at risk of caries or cracks based on pathologies and treatment history.Drawing on research from how teeth experience pain, the pulp's immune response and how dental histology affects restoration, the risk assessment has been proven to be an effective tool over the last 20 years, especially where x-rays do not identify a cause of symptoms. Now that we understand how gaps and cracks cause pain and sensitivity, identifying them early is the next step for more conservative treatment.Article referenced in this episode:Brannstrom M. The hydrodynamic theory of dentinal pain: sensation in preparations, caries, and the dentinal crack syndrome. Journal of Endodontics. 1986;12(10):453-457Galler K., Et al. Inflammatory response mechanisms of the dentine–pulp complex and the periapical tissues. Int J Mol Sci. 2021 Feb; 22(3):1480Milicich G, Rainey J T. Clinical presentations of stress distribution in teeth and the significance in operative dentistry. Pract Periodont Aesthet Dent. 2000;12(7):695-700.Larson TD, Douglas WH, Geistfeld RE. Effect of prepared cavities on the strength of teeth. Oper Dent. 1981(6)2-5. Send us a Text Message.Upcoming programs:September 16: Biomimetic MastershipOctober 11-12: In-Person WorkshopLearn more at allemancenter.com/trainingLearn more about Dr. Alleman's work at training programs at allemancenter.com.Instagram @david.alleman.dds@davey_alleman_dmd@allemancenter.comYouTube@allemancenter

Early diagnosis and treatment of dental pathologies allows for more conservative treatments while saving patients time and money. When developing the Six Lessons Approach to Biomimetic Dentistry, Dr. David Alleman created a risk assessment for determining if teeth were at risk of caries or cracks based on pathologies and treatment history.Drawing on research from how teeth experience pain, the pulp's immune response and how dental histology affects restoration, the risk assessment has been proven to be an effective tool over the last 20 years, especially where x-rays do not identify a cause of symptoms. Now that we understand how gaps and cracks cause pain and sensitivity, identifying them early is the next step for more conservative treatment.Article referenced in this episode:Brannstrom M. The hydrodynamic theory of dentinal pain: sensation in preparations, caries, and the dentinal crack syndrome. Journal of Endodontics. 1986;12(10):453-457Galler K., Et al. Inflammatory response mechanisms of the dentine–pulp complex and the periapical tissues. Int J Mol Sci. 2021 Feb; 22(3):1480Milicich G, Rainey J T. Clinical presentations of stress distribution in teeth and the significance in operative dentistry. Pract Periodont Aesthet Dent. 2000;12(7):695-700.Larson TD, Douglas WH, Geistfeld RE. Effect of prepared cavities on the strength of teeth. Oper Dent. 1981(6)2-5. Send us a Text Message.Registration for the September Biomimetic Mastership is now open at allemancenter.com/mastership.Learn more about Dr. Alleman's work at training programs at allemancenter.com.Instagram @david.alleman.dds@davey_alleman_dmd@allemancenter.comYouTube@allemancenter

References Nature Reviews Endocrinology 2020.volume 16:224–233 Blood Cancer J. 2024 Dec; 14(1): 24 Blood (2009) 114 (22): 1349. BioMedicine Hub 2021. 6:138-144. Int J Mol Sci. 2019 Mar; 20(5):1223. Lamm, R. 1969. "Does anybody really know what time it is? "[CTA lp] https://youtu.be/9FzCWLOHUes?si=kh_0eQNVliY_YieT Miller, S. 1970. "Industrial military complex blues. [Steve Miller Band V. lp] https://youtu.be/VNQsNq4zBIM?si=xeB3npYCqIw287_q Byrd. J. 1969. "American Metaphysical Circus" https://youtu.be/sb8Q4EHozjU?si=93zpSd_6clptKZGe Schubert, F. 1825 Symphony 9 in C major D. 944 https://youtu.be/bA6pzRx6gBE?si=h5qwXCKS2ZIkAIkv --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Nature 2024.volume 629, pages 417–425 Front. Immunol., 26 April 2019 Sec. NK and Innate Lymphoid Cell Biology. Nature Communications 2020.volume 11. Article 2437 Scientific Reports 2018. volume 8.Article 8700 Int J Mol Sci. 2020 Sep; 21(18): 6497 Hunter-Garcia& Lesh,P. 1969. "Cumberland Blues" On [Workingman's Dead lp.] https://youtu.be/xosZDm01ffc?si=fydGeAchCEAK_5vZ Haydn, FJ. 1784. Symphony No 101 D major "Die Uhr“ https://youtu.be/jK9EPZ3qdgU?si=d25AWgnswI3OKU_5 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Circulation. 2023.Oct 17;148(16):1231-1249. Int J Mol Sci . 2019. Oct 11;20(20):5028. Front Immunol. 2019; 10: 1706 Mastin, T. 1967 "How do you Feel" [Jefferson Airplane]. Surrealistic Pillow.lp. https://youtu.be/iWUa-rKT-oY?si=1M9496MbDUBGuj0A Hunter, Garcia, Kreutzman. 1975. "Franklin's Tower" [ Grateful Dead. Blues for Alah].lp. https://youtu.be/55TOIJxKc74?si=2wiiTKbWjw5LQvxF Haydn, FJ. 1790. String Quartet in D Major, Op. 64 No. 5 https://youtu.be/vNN_Kbuf7_U?si=KSfUc226hIIAmcy- --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

La toxicité sérotoninergique est une condition de santé principalement induite par cause médicamenteuse qui est loin d'être méconnue. Toutefois, son incidence dans la pratique n'est pas clairement rapportée. Quand faut-il véritablement s'en méfier et comment assurer un traitement optimal? Trait pharmacien en discute avec Mathieu Desgroseilliers, pharmacien au CISSS de la Montérégie-Est, membre de nos deux Regroupements de pharmaciens experts en urgence et en soins intensifs et détenteur de la certification américaine en soins critiques du BPS. Références : - Chiew AL, Buckley NA. The serotonin toxidrome: Shortfalls of current diagnostic criteria for related syndromes. Clin Toxicol (Phila) 2022;60(2):143-58. - Francescangeli J, Karamchandani K, Powell M et coll. The serotonin syndrome: From molecular mechanisms to clinical practice. Int J Mol Sci 2019;20(9):2288. - Poian LR, Chiavegatto S. Serotonin syndrome: The role of pharmacology in understanding its occurrence. Cureus 2023;15(5):e38897.

In an effort to protect us from getting killed by something we've ingested, our brain's vomit control center processes a lot of information from several different places … and sometimes is a little overly cautious.   LEARN MORE To learn more about this topic, start your googling with these keywords:  Emesis: The act of vomiting Vomiting: The oral eviction of gastrointestinal contents due to contractions in the gut and stomach. Nausea: A diffuse sensation of uneasiness and discomfort often felt as the need to vomit. Vomiting Center: An area in the brain's medulla oblongata that initiates and controls emesis. Chemoreceptor Trigger Zone: An area in the area postrema of the medulla oblongata that is sensitive to certain toxic chemicals in the blood.  Nucleus Tractus Solitarius: A region in the medulla oblongata that receives input from the cardiovascular, respiratory and GI systems.  Vagus Nerve: A cranial nerve that regulates internal organ functions, including vomiting.  Vestibular System: A Sensory system that provides our brain with information about motion, head position, and spatial positioning for balance. SUPPORT MINUTEEARTH If you like what we do, you can help us!: Become our patron:   Share this video with your friends and family Leave us a comment (we read them!)   CREDITS David Goldenberg | Script Writer, Narrator and Director Arcadi Garcia i Rius | Illustration, Video Editing and Animation  Nathaniel Schroeder | Music MinuteEarth is produced by Neptune Studios LLC      OUR STAFF Lizah van der Aart • Sarah Berman • Arcadi Garcia i Rius David Goldenberg • Melissa Hayes • Alex Reich  Henry Reich • Peter Reich • Ever Salazar Alexander Vidal • Leonardo Souza • Kate Yoshida   OUR LINKS Youtube | TikTok |   Twitter |   Instagram |   Facebook |   Website |   Apple Podcasts |    REFERENCES Singh P, Yoon SS, Kuo B. Nausea: a review of pathophysiology and therapeutics. Therap Adv Gastroenterol. 2016;9(1):98-112. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699282/ Hasler, W. (2013). Pathology of emesis: its autonomic basis. Handbook of Clinical Neurology, Vol. 117 (3rd series) Autonomic Nervous System. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/24095137/ Zhong W, Shahbaz O, Teskey G, Beever A, Kachour N, Venketaraman V, Darmani NA. Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems. Int J Mol Sci. 2021 May 28;22(11):5797. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/34071460/ Kowalski A, Rapps N, Enck P. Functional cortical imaging of nausea and vomiting: a possible approach. Auton Neurosci. 2006 Oct 30;129(1-2):28-35. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/16945593/ Hornby, PJ. Central neurocircuitry associated with emesis. Am J Med. 2001 Dec 3;111 Suppl 8A:106S-112S. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/11749934/ Kuo, Braden. (2022). Personal Communication. Director of the Center for Neurointestinal Health at Mass General. https://www.massgeneral.org/doctors/17189/brad-kuo

References Nutrients. 2021 Feb; 13(2): 413. Advances in Clinical ChemistryVolume 64, 2014, Pages 117-177. Front Physiol. 2020; 11: 796. Int J Mol Sci. 2023 Sep; 24(18): 13942. J Diabetes Investig. 2023. Oct;14(10):1148-1156. Nutrients. 2022 Jun 12;14(12):2438 RNA Biol. 2023; 20(1): 737–749. Clinica Chimica ActaVolume 508, Pages 61-68 Kirwan, Danny. 1971. "Sands of Time" Fleetwood Mac Lp Future Games https://youtu.be/1Jkp34jMeEw?si=fRzdAiA525bHRX5k --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

References Front Immunol. 2023; 14: 1151166. Int J Mol Sci. 2019 Jan; 20(2): 443. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Hormone optimization is essential for maintaining a healthy weight, and one of the most important hormones for fat loss is leptin. Leptin helps our bodies maintain a healthy weight by communicating with the brain when fat mass is accumulating, so that the brain can respond by reducing hunger and increasing energy expenditure. Unfortunately, leptin-resistance can develop, causing our brain to stop responding to leptin appropriately, causing the body to gain more and more fat. In this episode, we will discuss the role of leptin and other hormones in the accumulation and loss of fat, and how to optimize these hormones naturally, without the use of harmful weight loss drugs. Citations Dornbush S, Aeddula NR. Physiology, Leptin. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537038/ https://www.novomedlink.com/diabetes/products/treatments/ozempic/about/mechanism-of-action.html Collins L, Costello RA. Glucagon-Like Peptide-1 Receptor Agonists. [Updated 2023 Jan 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551568/ Müller TD, Finan B, Bloom SR, et al. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019;30:72-130. doi:10.1016/j.molmet.2019.09.010 Hira T, Trakooncharoenvit A, Taguchi H, Hara H. Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity. Int J Mol Sci. 2021;22(12):6623. Published 2021 Jun 21. doi:10.3390/ijms22126623 6. Anand David AV, Arulmoli R, Parasuraman S. Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacogn Rev. 2016;10(20):84-89. doi:10.4103/0973-7847.194044 --- Support this podcast: https://podcasters.spotify.com/pod/show/elanie-welch/support

Skin conditions can be tricky and frustrating for both patient and practitioner. This is where the skills of Rebecca Hughes shine. Her detective-like  approach in her quest to help her patients plus years of clinical practice have given her significant expertise in managing skin conditions. Today we embark on Part 1 of Atopic Dermatitis, commonly called Eczema, how we can tease the presentation apart from other disorders. We'll discuss where the foundations of natural medicine (ie. the gastrointestinal immune response) is placed in the therapeutic approach, considering the significant stress which patients are in, and delve into some of the best approaches and pitfalls of common therapies.We can't tell you much now, but this is the herald of something exciting for practitioners in the near future. Also, watch out for Part 2 of Eczema, plus further episodes on how we can help patients with other skin disorders. REFERENCES:Etiology of Atopic Dermatitis:Atopic Dermatitis. Health Topics. Nat Inst Athr Musculoskel Skin Dis. Stanway A. Atopic Dermatitis. Dermney NZ. 2004 Feb. Updated: Jarret P. 2021 Feb, 2023 May. (Accessed 2023 Sept 24). Galli E, Cincola B, Carello R, et al. Atopic Dermatitis. Acta Biomed. 2020;91(Suppl 11):e2020011.  Guttate Psoriasis:Saleh D, Tanner LS. Guttate Psoriasis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. [Updated 2023 Jul 31] (Accessed 2023 Sept 24): Dermatitis Herpetiformis: Al-Tameemi A, Elyoussfi S, Coulson I. Dermatitis Herpetiformis. Dermnet NZ. 2023 Mar. (Accessed 3023 Sept 24). Nutritional Approach to inflammatory skin disorders: Diotallevi F, Campanati A, Emanuela Martina E, et al. The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review. Nutrients. 2022 Feb; 14(3): 591.Kanda N, Hoashi T, Saeki H. Nutrition and Atopic Dermatitis. J Nippon Med Sch. 2021 Jun 30;88(3):171-177.Balić A, Vlašić D, Žužul K, et al. Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases. Int J Mol Sci. 2020 Jan 23;21(3):741.Charoenngam N, Holick MF. Immunologic Effects of Vitamin D in Human Health and Disease. Nutrients. 2020 Jul;12(7):2097. Histamine Intolerance:Histamine Intolerance (impaired histamine degradation)Low-Histamine Diet in Atopic DermatitisHistamine Intolerance- A Pseudoallergic reaction

Bezglutenowa, bezlaktozowa, bezmleczna, bezmięsna to tylko przykłady diet eliminacyjnych, które zyskują coraz większą popularność wśród Polaków. Medycznym wskazaniem do eliminacji określonych produktów spożywczych są przed wszystkim alergie i nietolerancje pokarmowe, a także choroby przewodu pokarmowego jak zespół jelita nadwrażliwego, SIBO czy celiakia. Jednak coraz więcej osób wyklucza różne pokarmy ze swoje diety aby wyeliminować objawy takie wzdęcia, biegunki lub wręcz zatrzymać postąp choroby. Jednak czy w każdym przypadku jest to słuszne? Gość: mgr Joanna Rojkowicz – dietetyk kliniczny, specjalistka od diet eliminacyjnych. Na co dzień współpracuje z osobami cierpiącymi na zespół jelita drażliwego, SIBO, choroby zapalne jelit i inne zaburzenia związane z przewodem pokarmowym. Oprócz tego Asia jest autorką szkoleń i e-booków z zakresu chorób układu pokarmowego i mikrobioty jelitowej. Asię znajdziecie na instagramie pod nickiem @love_fodmap oraz stronie internetowej: www.joannarojkowicz.pl W odcinku znajdziesz odpowiedzi m. in. na następujące pytania: Co to są diety eliminacyjne i kiedy je stosujemy? Czym różni się alergia od nietolerancji pokarmowej? Czym jest nietolerancja laktozy i histaminy? Czym jest mikrobiota jelitowa i jak wpływa na nasze zdrowie? Czym jest dieta low FODMAP? Czy diety eliminacyjne są niebezpieczne? Co możemy zrobić, żeby zmniejszyć ryzyko skutków ubocznych diet eliminacyjnych? Jakie są najczęściej popełniane błędy na dietach eliminacyjnych? Czy musimy eliminować gluten i nabiał w chorobach autoimmunologicznych? Czym jest efekt placebo i nocebo? Czym jest mimikra molekularna? Czy osoby z chorobami tarczycy powinny unikać goitrogenów? Lista publikacji o których wspominamy w podcaście: Vernia P. i wsp. Diagnosis of lactose intolerance and the "nocebo" effect: the role of negative expectations. Dig Liver Dis. 2010 Sep;42(9):616-9. Petroski W. i Minich D.M. Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds. Nutrients. 2020 Oct; 12(10): 2929. Moosavian S.P. i wsp. Effects of dairy products consumption on inflammatory biomarkers among adults: A systematic review and meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2020 Jun 9;30(6):872-888. Cavero-Redondo I. i wsp. Milk and Dairy Product Consumption and Risk of Mortality: An Overview of Systematic Reviews and Meta-Analyses. Adv Nutr. 2019 May 1;10(suppl_2):S97-S104. Soedamah-Muthu S.S. i de Goede J. Dairy Consumption and Cardiometabolic Diseases: Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies. Curr Nutr Rep. 2018 Dec;7(4):171-182. Gao D. i wsp. Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response meta-analysis. PLoS One. 2013 Sep 27;8(9):e73965. Companys J. i wsp. Fermented dairy foods rich in probiotics and cardiometabolic risk factors: a narrative review from prospective cohort studies. Crit Rev Food Sci Nutr. 2021;61(12):1966-1975. Van Buiten Ch. i Elias R.J. Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols. Int J Mol Sci. 2021 Jan 8;22(2):595. Calabriso N. i wsp. Non-Celiac Gluten Sensitivity and Protective Role of Dietary Polyphenols. Nutrients. 2022 Jul; 14(13): 2679. Pi X. i wsp. A review on polyphenols and their potential application to reduce food allergenicity. Crit Rev Food Sci Nutr. 2022 May 23;1-18. Camilleri M. Leaky gut: mechanisms, measurement and clinical implications in humans. Gut. 2019 Aug;68(8):1516-1526. Lerner A. i Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmun Rev. 2015 Jun;14(6):479-89. Ihnatowicz P. i wsp. The importance of gluten exclusion in the management of Hashimoto's thyroiditis. Ann Agric Environ Med. 2021 Dec 29;28(4):558-568.

Nerw błędny jest kluczowym elementem autonomicznego układu nerwowego, który unerwia większość narządów, zwłaszcza tych w obrębie przewodu pokarmowego. Nerw błędny jest głównym składnikiem osi neuroendokrynnoimmunologicznej, która zapewnia regulację wrodzonej odpowiedzi odpornościowej przed zakażeniami i stanem zapalnym, pomagając organizmowi przywrócić równowagę. Z tego powodu stymulacja nerwu błędnego jest aktualnie intensywnie badany pod kątem przeciwzapalnego potencjału terapeutycznego w niektórych chorobach. Gość: dr Maciej Duczyński – fizjoterapeuta i student osteopatii. Od lat pasjonuje się układem nerwowym i możliwościami poprawy jego funkcjonowania poprzez terapię manualną. Maciek popularyzuje metodę elektrostymulacji nerwu błędnego w leczeniu pacjentów ze schorzeniami autoimmunologicznymi, zaburzeniami funkcji przewodu pokarmowego i depresją. Misją Maćka jest przede wszystkim edukacja i pokazywanie ludziom, że osiągnięcie zdrowia nie musi być bardzo skomplikowane. Na co dzień pracuje z pacjentami w gabinecie Triada Zdrowia na warszawskich Włochach oraz prowadzi szkolenia dla fizjoterapeutów w firmie Neuroprojekt. Oprócz tego Maćka znajdziecie na instagramie pod nickiem @duczynski.m W odcinku znajdziesz odpowiedzi m. in. na następujące pytania: Na czym polega praca fizjoterapeuty i osteopaty? Czym jest terapia manualna? Dlaczego chorujemy? Jak emocje i stres wpływają nasze ciało? Czym jest zmienność rytmu zatokowego (HRV)? Czym jest nerw błędny i czy ma związek z chorobami? Czym jest teoria poliwagalna? Jak możemy stymulować nerw błędny? Czy elektrostymulacja nerwu błędnego jest metoda leczenia chorób autoimmunologicznych i metabolicznych? Lista publikacji o których wspominamy w podcaście: Bonaz B. i wsp. Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation. J Physiol. 2016 Oct 15;594(20):5781-5790. Kelly M.J. i wsp. Manipulation of the inflammatory reflex as a therapeutic strategy. Cell Rep Med. 2022 Jul 19;3(7):100696. Kuzior K. i Gorczyca W. Odruch zapalny jako przykład współzależności pomiędzy układem odpornościowym i nerwowym. Chemistry, environment, biotechnology 2010, XIV, 139–151. Bellocchi Ch. i wsp. The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases. Int J Mol Sci . 2022 Feb 23;23(5):2449. Adlan A.M. i wsp. Autonomic function and rheumatoid arthritis—A systematic review. Semin. Arthritis Rheum. 2014, 44, 283–304. Ghia J.-E. i wsp. Vagus nerve integrity and experimental colitis. Am. J. Physiol. Liver Physiol. 2007, 293,G560–G567. Koopman F.A. i wsp. Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 2016, 113, 8284–8289 Sorski L. i Gidron Y. The Vagal Nerve, Inflammation, and Diabetes-A Holy Triangle. Cells. 2023 Jun 15;12(12):1632. Fang J. i wsp. Transcutaneous Vagus Nerve Stimulation Modulates Default Mode Network in Major Depressive Disorder. Biol Psychiatry . 2016 Feb 15;79(4):266-73. de Moraes T.l. i wsp. Brief periods of transcutaneous auricular vagus nerve stimulation improve autonomic balance and alter circulating monocytes and endothelial cells in patients with metabolic syndrome: a pilot study. Bioelectron Med. 2023 Mar 31;9(1):7. Hilz M.J. Transcutaneous vagus nerve stimulation - A brief introduction and overview. Auton Neurosci. 2022 Dec;243:103038. Inbaraj G. i wsp. Immediate Effects of OM Chanting on Heart Rate Variability Measures Compared Between Experienced and Inexperienced Yoga Practitioners. Int J Yoga. 2022 Jan-Apr;15(1):52-58. Black D.S. i Slavich G.M. Mindfulness meditation and the immune system: a systematic review of randomized controlled trials.Ann N Y Acad Sci. 2016 Jun;1373(1):13-24.

Cukrzyca to przewlekła choroba metaboliczna charakteryzująca się podwyższonym stężeniem glukozy we krwi, która z czasem prowadzi do poważnych konsekwencji jak uszkodzenie serca, naczyń krwionośnych, oczu, nerek i nerwów. Najczęstszą postacią jest cukrzyca typu 2, która ma przed wszystkim podłoże związane z nieprawidłowym stylem życia i jest typową chorobą cywilizacyjną. Częstość występowania cukrzycy z roku na rok rośnie na całym świecie. W 2018 roku w Polsce na cukrzycę było chorych prawie 3 mln dorosłych. Tymczasem dane te mogą być nieoszacowane, gdyż część osób nie wie, że ma cukrzycę lub ma tzw. stan przedcukrzycowy. Gość: Moim dzisiejszym gościem jest dr hab. n. med. Anna Jeznach-Steinhagen, naukowiec, dydaktyk, ale przede wszystkim praktykujący lekarz diabetolog. Pani doktor specjalizuje się w zaburzeniach metabolicznych ze szczególnym uwzględnieniem cukrzycy ciążowej oraz otyłości. Od ponad 20 lat jest zatrudniona w Zakładzie Dietetyki Klinicznej Warszawskiego Uniwersytetu Medycznego jako wykładowca. Oprócz tego od wielu lat bierze czynny udział w pracach badawczych we współpracy z jednostkami naukowymi w całym kraju. Pani doktor pracuję w dwóch wiodących ośrodkach o trzecim, najwyższym stopniu referencyjności dla kobiet w ciąży z cukrzycą - Instytucie Matki i Dziecka oraz Szpitalu klinicznym im. ks. Anny Mazowieckiej przy ul. Karowa w Warszawie. Prowadzi również prywatną praktykę na warszawskim Ursynowie: https://www.poradniacukrzycowa.pl/ Ponadto popularyzuje wiedzę medyczną na swoim kanale na instagramie pod nickiem @dr.jeznach_diabetolog W odcinku znajdziesz odpowiedzi m. in. na następujące pytania: Dlaczego coraz więcej osób choruje na cukrzycę? Jakie są objawy cukrzycy? Jakie są rodzaje cukrzycy? Czy cukrzyca jest dziedziczna? Jakie badania warto wykonać aby rozpoznać stan przedcukrzycowy i/lub cukrzycę? Czym jest hemoglobina glikowana i kiedy ją wykonujemy? Czy warto badać insulinę na czczo? Jakie są normy dla insuliny? Czy insulinooporność to choroba i można ją zdiagnozować? Czym jest błędne koło insulinooporności? Czym jest wskaźnik HOMA i QUCKI? Czy insulinooporność jest przyczyną otyłości i trudności ze zmniejszeniem masy ciała? Czy kortyzol powoduje insulinooporność? Co możemy zrobić aby zmniejszyć ryzyko cukrzycy? Jak często występuje cukrzyca ciążowa? Czy cukrzyca wpływa na płodność? Jaki jest związek insuliny z chorobą Alzheimera? Jak aktualnie leczymy cukrzycę? Lista publikacji o których wspominamy w podcaście: https://www.who.int/news-room/fact-sheets/detail/diabetes https://pacjent.gov.pl/artykul/cukrzyca-w-liczbach Polskie Towarzystwo Diabetologiczne: Zalecenia kliniczne dotyczące postępowania u osób z cukrzycą 2023. Stanowisko Polskiego Towarzystwa Diabetologicznego. Curr. Top Diabetes, 2023; 3: 1–140 Galicia-Garcia U. i wsp.Pathophysiology of Type 2 Diabetes Mellitus. Int J Mol Sci. 2020 Aug 30;21(17):6275. Janoutová J. i wsp. Is Alzheimer's disease a type 3 diabetes? A review. Cent Eur J Public Health. 2022 Sep;30(3):139-143.

Im ersten Teil dieser Podcast-Episode geht es um die spannende Aminosäure Glutamin. Hier findest du qualitativ hochwertiges Glutamin: https://www.ironmaxx.de/de/catalog/product/view/id/1507/s/glutamin-pro-pulver-500g/ 10% mit dem Code Larissa10 bei IronMaxx Nutrition * Werbung Auszug der Studien und Meta-Analysen: Carvalho-Peixoto J, Alves RC, Cameron LC. Glutamine and carbohydrate supplements reduce ammonemia increase during endurance field exercise. Appl Physiol Nutr Metab. 2007 Dec;32(6):1186-90. doi: 10.1139/H07-091. PMID: 18059593. de Souza AZ, Zambom AZ, Abboud KY, Reis SK, Tannihão F, Guadagnini D, Saad MJ, Prada PO. Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study. Nutrition. 2015 Jun;31(6):884-9. doi: 10.1016/j.nut.2015.01.004. Epub 2015 Jan 29. PMID: 25933498. Perna S, Alalwan TA, Alaali Z, Alnashaba T, Gasparri C, Infantino V, Hammad L, Riva A, Petrangolini G, Allegrini P, Rondanelli M. The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review. Int J Mol Sci. 2019 Oct 22;20(20):5232. doi: 10.3390/ijms20205232. PMID: 31652531; PMCID: PMC6834172 Kim, H., Glutamine as an immunonutrient, 2011. Perna et. Al., The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review, 2019. Wang et. Al., Glutamine and intestinal barrier function, 2015. Legault Z, Bagnall N, Kimmerly DS. The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise. Int J Sport Nutr Exerc Metab. 2015 Oct;25(5):417-26. doi: 10.1123/ijsnem.2014-0209. Epub 2015 Mar 26. PMID: 25811544. Viel Spaß mit der Folge, Deine Larry

Grzyby to fascynujące organizmy, które nie należą ani do królestwa roślin ani do królestwa zwierząt. Przez długi czas uważano je za pokarm pozbawiony wartości odżywczych i ciężkostrawny. Jednak w ostatnim czasie grzyby stały się popularne, a nawet modne. Można powiedzieć, że na nowo odkrywamy ich właściwości prozdrowotne. Coraz więcej badań pokazuje, że grzyby są skarbnicą związków odżywczych oraz wielu interesujących substancji, które potencjalnie mogą wpływać na prewencję chorób cywilizacyjnych, a nawet zostać wykorzystane jako leki. Gość: Prof. dr hab. Bożena Muszyńska jest profesorem nauk medycznych i nauk o zdrowiu na Wydziale Farmaceutycznym Collegium Medicum Uniwersytetu Jagiellońskiego, farmaceutką kliniczną, mykologiem i botanikiem. Od 34 lat skupia się na badaniu i promocji wartości terapeutycznej i dietetycznej grzybów. W odcinku znajdziesz odpowiedzi m. in. na następujące pytania: Jak różnorodne biologiczne są grzyby? Czy grzyby mogą być mięsożerne? Jaki jest największy grzyb (organizm) na świecie? Ile prawdy jest w serialach fabularnych o grzybach? Skąd wziął się pogląd, że grzyby nie mają żadnych wartości odżywczych? Jakie wyjątkowe substancje o potencjale prozdrowotne znajdziemy w grzybach? Czy grzyby są źródłem leków i w jakich chorobach mają potencjał leczniczy? Czy pieczarki są zdrowe? Czym jest ergotioneina i dlaczego jest taka ważna? Czy kordycepina jest lekiem przeciwnowotworowym? Czy istnieją wytyczne ile powinniśmy jeść grzybów? Czy grzyby zawierają prekursory „hormonu szczęścia”? W jakiej formie najlepiej jeść grzyby? Czy muchomory są jadalne? Jakie są „nietypowe” grzyby jadalne? Lista publikacji o których wspominamy w podcaście: Ba D.J. i wsp. Mushroom intake and depression: A population-based study using data from the US National Health and Nutrition Examination Survey (NHANES), 2005-2016. J Affect Disord. 2021 Nov 1;294:686-692. Fijałkowska A. i wsp. Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder. Foods. 2022 May 20;11(10):1489 Beelman R.B i wsp. Is ergothioneine a ‘longevity vitamin' limited in the American diet? J Nutr Sci. 2020 Nov 11;9:e52. Apparoo Y. i wsp. Ergothioneine and its prospects as an anti-ageing compound. Exp Gerontol. 2022 Dec;170:111982. Lam-Sidun D. i wsp. Mushroom-Derived Medicine? Preclinical Studies Suggest Potential Benefits of Ergothioneine for Cardiometabolic Health. Int J Mol Sci. 2021 Mar 23;22(6):3246. Ey J. i wsp. Dietary sources and antioxidant effects of ergothioneine. J Agric Food Chem. 2007 Aug 8;55(16):6466-74. Jędrejko K.J. i wsp. Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity. Foods. 2021 Oct 30;10(11):2634. Jędrejko K. i wsp. Effect of Cordyceps spp. and Cordycepin on Functions of Bones and Teeth and Related Processes: A Review. Molecules. 2022 Nov 24;27(23):8170.  Zięba P. i wsp. Culinary and Medicinal Mushrooms: Insight into Growing Technologies. Acta Mycologica 2020, 55, 2, 5526. Krakowska A. i wsp. Selected edible medicinal mushrooms from Pleurotus genus as an answer for human civilization diseases. Food Chem. 2020 Oct 15;327:127084. Włodarczyk A. i wsp.Pleurotus spp. Mycelia Enriched in Magnesium and Zinc Salts as a Potential Functional Food. Molecules. 2020 Dec 31;26(1):162. Kała K. i wsp. Fruiting bodies of selected edible mushrooms as a potential source of lovastatin. European Food Research and Technology 2020, 246,713–722. Kanał o grzybach o którym polecałyśmy w trakcie podcastu: https://www.youtube.com/@ytpaweligrzyby

Dr. Ralph W. Moss and son Ben discuss the healing and preventive properties of the readily available, inexpensive and delicious, humble little parsley plant.   Join us for another fascinating journey as we dive 'Beyond the Garnish' into the remarkable world of parsley and its component, Apigenin. This humble herb, often relegated to the sidelines of our plates, holds an impressive secret - the potential to significantly impact the fight against cancer. Program Notes: For more information on cancer-fighting foods and supplements, please visit our website: https://www.themossreport.com 5 Defenders Mushroom Blend https://shop.realmushrooms.com/products/organic-mushroom-blend-capsules?ref=391 “A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD Olive Oil From the Raw https://www.olivefromtheraw.com/?aff=2 “A study of over 1,000,000 people shows that daily consumption of 2 Tbsp of high quality, extra virgin olive oil that contain polyphenols, results in a 30-40% decrease in cancer incidents.” – Ralph W. Moss, PhD For Dr. Moss' recommended products list, please visit https://www.themossreport.com/recommended-products/ The full scope of research on apigenin and cancer: https://pubmed.ncbi.nlm.nih.gov/?term=apigenin+cancer The Indian review article: Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models https://pubmed.ncbi.nlm.nih.gov/35752426/ The German clinical trial: Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703843/ Recommended parsley intake: Approximately 0.79 tablespoons or 2.37 teaspoons of chopped fresh parsley would provide 10 mg of apigenin. TAKE about one tablespoon OR THE EQUIVALENT AMT. OF DRIED PARSLEY (SEE BELOW) TWICE PER DAY. For 0.69 grams of dried parsley flakes: 0.69 grams / 0.8 grams per teaspoon ≈ 0.86 teaspoons So, approximately one teaspoon 0.86 teaspoons of dried parsley flakes would provide 10 mg of apigenin. OR TAKE THIS TWICE PER DAY. NOTE: PATIENTS IN THE GERMAN STUDY ALSO RECEIVED EGCG (GREEN TEA) AT THE SAME TIME. Based on the average amount of EGCG in one gram of Japanese Sencha green tea leaves (47.3 milligrams), and assuming that you're using one teaspoon (about 2.5 grams) of tea leaves to brew 6 ounces of tea, you can expect to get around 118.25 milligrams of EGCG in your cup of tea. A short bibliography on apigenin and cancer: Shukla S, Gupta S. Apigenin: a promising molecule for cancer prevention. Pharm Res. 2010;27(6):962-978. Salehi B, Venditti A, Sharifi-Rad M, et al. The therapeutic potential of apigenin. Int J Mol Sci. 2019;20(6):1305. Chen AY, Chen YC. A review of the dietary flavonoid, apigenin, on cancer prevention and treatment. Curr Med Chem. 2013;20(19):2570-2581. Fang J, Xia C, Cao Z, Zheng JZ, Reed E, Jiang BH. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J. 2005;19(3):342-353. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674. Kim BR, Seo HS, Ku JM, et al. Apigenin inhibits cancer stem cell-like phenotypes in human glioblastoma cells via suppression of c-Met signaling. Phytother Res. 2016;30(5): 800-807. Lu L, Sun T, Chen X, et al. Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through the AKT/GSK-3β/Snail signaling pathway. Oncol Rep. 2016;35(1):369-374. Lu Z, Xu S, ER P, et al. Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3-derived sphere-forming cells. Mol Med Rep. 2015;11(4): 2850-2856. Wang J, Wu J, Zhang X, et al. Apigenin suppresses the growth of colorectal cancer cells by targeting Twist-mediated epithelial-mesenchymal transition. Mol Med Rep. 2018;17(5): 7305-7310. Yao J, Zhao L, Zhao Q, et al. Apigenin inhibits ovarian cancer stem cell-like properties through the modulation of the Twist1/TGF-β1/Smad3 pathway. Oncol Rep. 2016;36(1): 512-520. For Dr. Moss' Red, Green, and Green Tea Smoothie recipes, visit The Moss Report. These smoothie recipes are just some examples of how you can incorporate natural compounds with potential health benefits into your diet.

This week we're joined by personal trainer and functional strength coach Theresa Racicot, who has been helping train circus artists since 2002 (that's before the first pole studio even opened, depending on how you measure it!). We cover a lot in this episode, including discussing hypermobility, functional strength & diet culture. You can find Theresa and Reimagym at https://reimagym.com/, on TikTok, Instagram and YouTube. Also some citations for some of the things I mention: - Co-incidence of neurodivergence & hypermobility: Csecs & Et al (2022) Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain, Front. Psychiatry, 02 February 2022 Sec. Psychological Therapy and Psychosomatics Volume 12 https://www.frontiersin.org/articles/10.3389/fpsyt.2021.786916/full?field=&journalName=Frontiers_in_Psychiatry&id=786916 - On the incidence of weight re-gain: Hall KD, Kahan S. Maintenance of Lost Weight and Long-Term Management of Obesity. Med Clin North Am. 2018 Jan;102(1):183-197. doi: 10.1016/j.mcna.2017.08.012. PMID: 29156185; PMCID: PMC5764193. - On body size not being indicative of health: Bombak A. Obesity, health at every size, and public health policy. Am J Public Health. 2014;104:e60–e67. - On epigenetic factors & body size (I'd recommend starting with Section 3) Mahmoud AM. An Overview of Epigenetics in Obesity: The Role of Lifestyle and Therapeutic Interventions. Int J Mol Sci. 2022 Jan 25;23(3):1341. doi: 10.3390/ijms23031341. PMID: 35163268; PMCID: PMC8836029. The Evidence-Based Pole Podcast aims to help pole dancers feel better on and off the pole by talking with experts and diving into relevant scientific research to find evidence-based insights we can apply to our pole journeys. It's a production of Slink Through Strength, the inclusive, evidence-based online pole studio, which can be found online at http://slinkthroughstrength.com/. #poledance #physicaltherapy #evidencebasedpractice --- Support this podcast: https://podcasters.spotify.com/pod/show/rosy-boa/support

Thyroid Talk with Dr. Angela Mazza, DORecorded Thursday, May 18, 2023SHOW NOTES EPISODE 18Thyroid DisruptorsHost: Dr. Angela Mazza, DOCo-host: Dawn Sheffield I'm Dr. Angela Mazza, D.O., a thyroid, endocrine, and metabolism specialist with a private practice in Central Florida.  My goal for this podcast is to define and demystify the thyroid gland, and thyroid-related medical conditions.  By providing information in an easy-to-understand format, we hope to help patients better understand the ways in which their bodies work, and to help them thrive.  My goal is to help us live more fulfilling lives by taking control of our health, to feel our best. I wanted to do this podcast to provide life-saving education and encourage patients to see a doctor in time to prevent or minimize damage.  That's deeply fulfilling.  I enjoy helping folks understand how all aspects of their lives are tied to both thyroid and overall health.  In fact, this is why I went into endocrinology.  It's a medical art that combines science with the study of our lives—and all that they encompass.   To recap just some of what we covered in this episode, not necessarily in this order:·        What EDCs are and how they may affect our thyroid function·        Specific EDCs, and where they can found.  If we don't know how we may be exposed, how can we avoid them?·        We also learned that we cannot completely avoid EDCs, but there are ways that we can better help our bodies handle them·        And best of all, we learned that we CAN impact our thyroid health!For information on supplements mentioned in various episodes of this podcast, please visit the Wellness Store at metaboliccenterforwellness.com   Citations, references, and additional information you may find helpful:Environmental Working Group, www.ewg.org/Buha A, Matovic V, Antonijevic B, Bulat Z, Curcic M, Renieri EA, Tsatsakis AM, Schweitzer A, Wallace D. Overview of cadmium thyroid disrupting effects and mechanisms. Int J Mol Sci 2018;19(5):1501.Gore, AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller. EDC-2: The Endocrine Society's Second Scientific Statement on endocrine-disrupting chemicals. Endocr Rev 2015;36(6):E1-E150.Kim MJ, Park YJ. Bisphenols and thyroid hormone. Endocrinol Metabo (Seoul) 2019;34(4):340-348Peckham S, Lowery D, Spencer S. Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice date and fluoride levels in drinking water. J Epidemiol Community Health 2015; 69(7):619-24Requena M, Lopez-Villen A, Hernandez AF, Parron T, Navarro A, Alarcon R. Environemental exposure to pesticides and risk of thyroid disease. Toxicol Lett 2019;15(315):55-63.Mazza A.  Thyroid Talk: An Integrative Endocrinologist's Guide to Optimal Thyroid Health.  Please watch for pre-order availability for Dr. Mazza's book, Thyroid Talk: An Integrative Endocrinologist's Guide to Optimal Thyroid Health.  As an added bonus, there will be an online master course, related to the book, to help guide you to optimal thyroid health.      We welcome your comments, show ideas, and questions for future episodes.  Please send them to thyroidtalk.mazza@gmail.com  (That's an email address—not a message bCheck out our YouTube channel - Dr. Angela Mazza, our website at Metabolic Center for Wellness, our FaceBook and our Instagram page.

Rochelle Waite has a different take on supporting women through the perimenopausal period. Instead of reaching first for "women's herbs", Rochelle instead goes back to grass roots Naturopathic principles. With Masters in Immunology, Reproductive Medicine and Women's Health Medicine she is perfectly placed to make practical recommendations to maintain her patients' enjoyment of life as they transition through perimenopause.Her reasoning? If cells aren't properly nourished then organs can't function efficiently, and if they don't work then herbs which ostensibly work on those organs could be thwarted.Working with basic nutrition and digestive enhancement, Rochelle brings about rejuvenation from the ground up to avoid unnecessary supplementation and hence improved compliance from her common sense approach.URL: https://rochellewaitenaturopath.com/ FB: https://www.facebook.com/rochellewaitenaturopath/References: Kanat M, Sipahioglu M, Arinc H, et al. Is lipid lowering treatment aiming for very low LDL levels safe in terms of the synthesis of steroid hormones? Med Hypotheses. 2007;69(1):104-12. Epub 2007 Jan 17. DOI: 10.1016/j.mehy.2006.10.058Schade DS, Shey L, Eaton RP. Cholesterol Review: A Metabolically Important Molecule. Endocr Pract. 2020 Dec;26(12):1514-1523. DOI: 10.4158/EP-2020-0347Hu J, Zhang Z, Shen WJ, et al. Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutr Metab (Lond). 2010;7:47. DOI: 10.1186/1743-7075-7-47Reid R, Abramson BL, Blake J, et al. Menopause and Osteoporosis Working Group. Managing Menopause. SOGC Clinical Practice Guideline. J Obstet Gynaecol Can. 2014 Sep;36(9):830-833. DOI: 10.1016/S1701-2163(15)30487-4Silva TR, Oppermann K, Reis FM, et al. Nutrition in Menopausal Women: A Narrative Review. Nutrients. 2021 Jul;13(7): 2149. DOI: 10.3390/nu13072149Medical & Health Articles. Foods for Menopause. Jean Hailes For Women's Health. 2023. (Accessed 2023 Mar 13). https://www.jeanhailes.org.au/news/foods-for-menopausePeters BA, Santoro N, Kaplan RC, et al. Spotlight on the Gut Microbiome in Menopause: Current Insights. Int J Womens Health. 2022;14:1059–1072. DOI: 10.2147/IJWH.S340491Lowe NM, Lowe NM, Fraser WD, Jackson MJ. Is there a potential therapeutic value of copper and zinc for osteoporosis? Proc Nutr Soc. 2002 May;61(2):181-5. DOI: 10.1079/PNS2002154Ciappolino V, Mazzocchi A, Enrico P, et al. N-3 Polyunsatured Fatty Acids in Menopausal Transition: A Systematic Review of Depressive and Cognitive Disorders with Accompanying Vasomotor Symptoms. Int J Mol Sci. 2018 Jun 23;19(7):1849. DOI: 10.3390/ijms19071849Ko SH, Kim HS. Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women. Nutrients. 2020 Jan 13;12(1):202. DOI: 10.3390/nu12010202Wong RH, Thaung Zaw JJ, Xian CJ, Howe PR. Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2020 Nov;35(11):2121-2131. DOI: 10.1002/jbmr.4115

En éste episodio Arturo nos traduce un interesante artículo llamado ''Éfectos hormonales sobre el folículo piloso''. *Referencias: Artículo: Hormonal Effects on Hair Follicles. Int J Mol Sci. 2020 Jul 28;21(15):5342. doi: 10.3390/ijms21155342. PMID: 32731328; PMCID: PMC7432488. Grymowicz M, Rudnicka E, Podfigurna A, Napierala P, Smolarczyk R, Smolarczyk K, Meczekalski B.

Thyroid Talk with Dr. Angela Mazza, DO  Recorded Friday, December 16, 2022SHOW NOTES EPISODE 14Epstein-Barr Virus & the Thyroid Host: Dr. Angela Mazza, DOCo-host: Dawn Sheffield I'm Dr. Angela Mazza, D.O., a thyroid, endocrine, and metabolism specialist with a private practice in Central Florida.  My goal for this podcast is to define and demystify the thyroid gland, and thyroid-related medical conditions.  By providing information in an easy-to-understand format, we hope to help patients better understand the ways in which their bodies work, and to help them thrive.  My goal is to help us live more fulfilling lives by taking control of our health, to feel our best. I wanted to do this podcast to provide life-saving education and encourage patients to see a doctor in time to prevent or minimize damage.  That's deeply fulfilling.  I enjoy helping folks understand how all aspects of their lives are tied to both thyroid and overall health.   In fact, this is why I went into endocrinology.  It's a medical art that combines science with the study of our lives—and all that they encompass.   To recap just some of what we covered in today's episode, not necessarily in this order:·       Epstein-Barr virus (EBV) is a common virus, and it's associated with Hashimoto thyroiditis;·       How Hashimoto thyroiditis can develop;·       EBV's four stages, and how it can spread;·       Vaccine development for EBV;·       EBV can reactivate in certain individuals, and worsen symptoms associated with autoimmune thyroid disease;·       Other conditions EBV can contribute to;·       Stress and lifestyle management, as well as nutraceutical therapies can help manage EBV reactivation;·       Tests to help chart a plan of action if EBV involvement is suspected;·       When might EBV testing be considered?;·       And best of all, we learned that we CAN impact our thyroid health!  For information on supplements mentioned in various episodes of this podcast, please visit the Wellness Store at metaboliccenterforwellness.com  Soon to be available for pre-order: “Thyroid Talk: An Integrative Endocrinologist's Guide to Optimal Thyroid Health” by Dr. Angela Mazza.  Citations, references, additional information re: materials mentioned in this episode:·       Campbell AW. Autoimmunity and the gut. Autoimmune Dis. 2014; Epub 2014 May 13.·       Dittfeld A, Gwizdek K, Michalski M, Wojnicz R.  A possible link between the Epstein-Barr virus infection and autoimmune thyroid disorders.  Cent Eur J Immunol 2016;41(3):297-301.·       Janegova A, Janega P, Rychly B, Kuracinova K, Babal P. The role of Epstein-Barr virus infection in the development of autoimmune thyroid disease. Endokrynol Pol 2015;66(2):132-6. ·       Pyzik A, Grywalska E, Matyjaszek-Matuszek B, Ludian J, Kiszczak-Bochyńska E, Smoleń A, Roliński J, Pyzik D. Does the Epstein-Barr virus play a role in the pathogenesis of Graves' disease? Int J Mol Sci 2019 Jun 27;20(13):3145·       https://www.niaid.nih.gov/news-events/nih-launches-clinical-trial-epstein-barr-virus-vaccine·       Mazza A.  Thyroid Talk: An Integrative Endocrinologist's Guide to OptimaCheck out our YouTube channel - Dr. Angela Mazza, our website at Metabolic Center for Wellness, our FaceBook and our Instagram page.

En este episodio, introducimos la controversia con la neurogénesis en el humano adulto, ya que hay diferentes estudios que no obtienen los mismos resultados que los estudios que afirman que existe la neurogénesis en el hipocampo adulto. Aportamos contexto histórico y detalles neurobiológicos que permiten abordar esta controversia con mayor rigor que el habitual en la divulgación en neurociencia y neurorrehabilitación. Entrevistamos a Jon Arellano, investigador en la Universidad de Yale, para aportar una visión crítica y actualizada de la controversia de la neurogénesis. Referencias del episodio: 1. Snyder (2018). Questioning human neurogenesis (https://www.nature.com/articles/d41586-018-02629-3). 2. The Snyder Lab. WTF! No neurogenesis in humans?? http://snyderlab.com/2018/03/07/wtf-no-neurogenesis-in-humans/ 3. Sorrells SF et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15;555(7696):377-381. doi: 10.1038/nature25975. Epub 2018 Mar 7. PMID: 29513649; PMCID: PMC6179355 (https://pubmed.ncbi.nlm.nih.gov/29513649/). 4. Dennis CV et al. Human adult neurogenesis across the ages: An immunohistochemical study. Neuropathol Appl Neurobiol. 2016 Dec;42(7):621-638. doi: 10.1111/nan.12337. Epub 2016 Aug 28. PMID: 27424496; PMCID: PMC5125837 (https://pubmed.ncbi.nlm.nih.gov/27424496/). 5. Moreno-Jiménez EP, Terreros-Roncal J, Flor-García M, Rábano A, Llorens-Martín M. Evidences for Adult Hippocampal Neurogenesis in Humans. J Neurosci. 2021 Mar 24;41(12):2541-2553. doi: 10.1523/JNEUROSCI.0675-20.2020. PMID: 33762406; PMCID: PMC8018741 (https://pubmed.ncbi.nlm.nih.gov/33762406/). 6. Moreno-Jiménez EP, Flor-García M, Terreros-Roncal J, Rábano A, Cafini F, Pallas-Bazarra N, Ávila J, Llorens-Martín M. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease. Nat Med. 2019 Apr;25(4):554-560. doi: 10.1038/s41591-019-0375-9. Epub 2019 Mar 25. PMID: 30911133 (https://pubmed.ncbi.nlm.nih.gov/30911133/). 7. Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH. Neurogenesis in the adult human hippocampus. Nat Med. 1998 Nov;4(11):1313-7. doi: 10.1038/3305. PMID: 9809557 (https://pubmed.ncbi.nlm.nih.gov/9809557/). 8. Cipriani S, Ferrer I, Aronica E, Kovacs GG, Verney C, Nardelli J, Khung S, Delezoide AL, Milenkovic I, Rasika S, Manivet P, Benifla JL, Deriot N, Gressens P, Adle-Biassette H. Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults. Cereb Cortex. 2018 Jul 1;28(7):2458-2478. doi: 10.1093/cercor/bhy096. PMID: 29722804 (https://pubmed.ncbi.nlm.nih.gov/29722804/9. 9. Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. 2018 Jul 5;23(1):25-30. doi: 10.1016/j.stem.2018.04.004. Epub 2018 Apr 19. PMID: 29681514; PMCID: PMC6035081 (https://pubmed.ncbi.nlm.nih.gov/29681514/). 10. Jon I Arellano, Brian Harding, Jean-Leon Thomas, Adult Human Hippocampus: No New Neurons in Sight, Cerebral Cortex, Volume 28, Issue 7, July 2018, Pages 2479–2481, https://doi.org/10.1093/cercor/bhy106. 11. Leal-Galicia P, Chávez-Hernández ME, Mata F, Mata-Luévanos J, Rodríguez-Serrano LM, Tapia-de-Jesús A, Buenrostro-Jáuregui MH. Adult Neurogenesis: A Story Ranging from Controversial New Neurogenic Areas and Human Adult Neurogenesis to Molecular Regulation. Int J Mol Sci. 2021 Oct 25;22(21):11489. doi: 10.3390/ijms222111489. PMID: 34768919; PMCID: PMC8584254 (https://pubmed.ncbi.nlm.nih.gov/34768919/). 12. Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, Rosoklija GB, Stankov A, Arango V, Dwork AJ, Hen R, Mann JJ. Human Hippocampal Neurogenesis Persists throughout Aging. Cell Stem Cell. 2018 Apr 5;22(4):589-599.e5. doi: 10.1016/j.stem.2018.03.015. PMID: 29625071; PMCID: PMC5957089 (https://pubmed.ncbi.nlm.nih.gov/29625071/). 13. Nogueira AB, Hoshino HSR, Ortega NC, Dos Santos BGS, Teixeira MJ. Adult human neurogenesis: early studies clarify recent controversies and go further. Metab Brain Dis. 2022 Jan;37(1):153-172. doi: 10.1007/s11011-021-00864-8. Epub 2021 Nov 5. PMID: 34739659 (https://pubmed.ncbi.nlm.nih.gov/34739659/). 14. Bernier PJ, Vinet J, Cossette M, Parent A. Characterization of the subventricular zone of the adult human brain: evidence for the involvement of Bcl-2. Neurosci Res. 2000 May;37(1):67-78. doi: 10.1016/s0168-0102(00)00102-4. PMID: 10802345 (https://pubmed.ncbi.nlm.nih.gov/10802345/). 15. Franjic D, Skarica M, Ma S, Arellano JI, Tebbenkamp ATN, Choi J, Xu C, Li Q, Morozov YM, Andrijevic D, Vrselja Z, Spajic A, Santpere G, Li M, Zhang S, Liu Y, Spurrier J, Zhang L, Gudelj I, Rapan L, Takahashi H, Huttner A, Fan R, Strittmatter SM, Sousa AMM, Rakic P, Sestan N. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron. 2022 Feb 2;110(3):452-469.e14. doi: 10.1016/j.neuron.2021.10.036. Epub 2021 Nov 18. PMID: 34798047; PMCID: PMC8813897 (https://pubmed.ncbi.nlm.nih.gov/34798047/. 16. Alvarez-Buylla A, Cebrian-Silla A, Sorrells SF, Nascimento MA, Paredes MF, Garcia-Verdugo JM, Yang Z, Huang EJ. Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis". Science. 2022 Apr 15;376(6590):eabn8861. doi: 10.1126/science.abn8861. Epub 2022 Apr 15. PMID: 35420933 (https://pubmed.ncbi.nlm.nih.gov/35420933/). 17. 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References Dr. Guerra's notes The Journal of Nutrition, Volume 137, Issue 3, March 2007, Pages 548–553 Front Immunol. 2019; 10: 1309. Int J Mol Sci. 2019 Oct 11;20(20):5028 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

References Front Immunol. 2019; 10: 1309. Int J Mol Sci. 2019 Oct 11;20(20):5028. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this episode, I explain anosmia and what you can do to aid in recovery. This episode is sponsored by McNeese Construction. Check out our store at www.se7en.surf where you will find cool items for you, your family, and your pets. To keep this podcast going please feel free to donate at www.paypal.me/yopistudio If you would like to read more on this topic or any other previous topics, you can do so by checking out our blog at https://yopistudio.blogspot.com/ Feel free to see what we are up to by following us at:  https://twitter.com/Dauricee https://www.facebook.com/yopistudio/ https://www.facebook.com/LouisianaEntertainmentAssociation/ To listen to the podcast, watch creative videos and skits go to https://www.youtube.com/channel/UCvn6tns6wKUwz9xZw11_vAQ/videos Interested in projects Daurice has worked on in the movie industry you can check it out at www.IMDb.com under Daurice Cummings. For comments or questions, you can reach us at yopi@post.com To read more about today's topic check out the references below. References: [i] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [ii] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [iii] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [iv] StatPearls, Anosmia September 25, 2021 https://www.ncbi.nlm.nih.gov/books/NBK482152/ [v] StatPearls, Anosmia September 25, 2021 https://www.ncbi.nlm.nih.gov/books/NBK482152/ [vi] StatPearls, Anosmia September 25, 2021 https://www.ncbi.nlm.nih.gov/books/NBK482152/ [vii] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [viii] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [ix] Chem Senses. 2017 Sep; 42(7): 513-523. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5863566/ [x] Chem Senses. 2016 May; 41(4): 293-299. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5006107/ [xi] Int J Mol Sci. 2021 Aug 18;22(16):8912. doi: 10.3390/ijms22168912. https://pubmed.ncbi.nlm.nih.gov/34445619/ [xii] Rhinology 55: 17-26, 2017 https://www.rhinologyjournal.com/Rhinology_issues/manuscript_1517.pdf [xiii] Int J Mol Sci. 2021 Aug; 22(16): 8912. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8396277/ [xiv] Int J Mol Sci. 2021 Aug; 22(16): 8912. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8396277/ [xv] Laryngoscope. 2002 Nov;112(11):2076-80. PMID: 12439184 www.greenmedinfo.com/article/lipoic-acid-may-have-therapeutic-value-treating-smell-dysfunction-following-vi [xvi] Am J Rhinol. 2008 May-Jun;22(3):292-6. PMID: 18588762 www.greenmedinfo.com/article/ginkgo-biloba-may-contribute-restoring-olfactory-loss [xvii] Arch Otolaryngol Head Neck Surg. 2009;135(10):1000-1004. doi:10.1001/archoto.2009.141 https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/410599 [xviii] Avicenna J Phytomed. 2022 Jan-Feb; 12(1): 1-7. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8801216/ [xix] Laryngoscope Investigative Otolaryngology December 25, 2020 https://onlinelibrary.wiley.com/doi/full/10.1002/lio2.513 [xx] Otolaryngol Head Neck Surg. 2015 May;152(5):954-8. doi: 10.1177/0194599815571272. Epub 2015 Feb 24. https://pubmed.ncbi.nlm.nih.gov/25715353/ [xxi] Cureus 13(9): e17829. doi:10.7759/cureus.17829 https://www.cureus.com/articles/68407-turmeric-as-a-possible-treatment-for-covid-19-induced-anosmia-and-ageusia  

References Cell Metabolism. 2016. 23, 1127–1139 Cells 2020, 9(1), 228 Front. Immunol., 31 May 2019 Int J Mol Sci. 2020 Nov; 21(22): 8609 Circ Res. 2018 Sep 14; 123(7): 868–885. Int J Mol Sci. 2019 Mar; 20(5): 1223 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

The ingredients in this supplement have been life changing for thousands of people. If you are looking for a way to help relieve your pain, improve your mobility, and decrease the amount of pain pills you are taking you have to check this out. Also, if you would like help improving your strength, balance, or range of motion you can setup a Breakthrough Exam HERE. Research Articles: 1. Int J Mol Sci. 2019 Sep 20; 20(17): 4101 2. Indian J Pharm Sci. 2011 May-Jun; 73(3): 255-261

Why is hemochromatosis so common? What is iron actually doing to the joint? Does phlebotomy help? What’s going on with iron and Popeye? These are the questions we tackle in the second episode of hemochromatosis: Iron and Bone! Brought to you by GSK. Intro :19 Today’s episode :29 Why is hemochromatosis so common? 1:06 The history of Popeye the Sailor Man 3:37 Treatment with phlebotomy 8:35 Why doesn’t join pain improve? 12:03 What is Kashin-Beck disease? 14:18 Mouse studies from the 1970s 19:45 What about histology? 25:36 Episode wrap-up 28:34 Disclosures: Brown reports no relevant financial disclosures. We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum References: Adams PC, et al. Hepatology. 1997;25:162-166. Adams PC, et al. N Engl J Med. 2005;352:1769-1778. Brighton CT, et al. Arthritis Rheum. 1970;13:849-857. Heiland GR, et al. Ann Rheum Dis. 2010;69:1214-1219. Hiyeda, K. Jap Med Sci. 1939;4:91-106. Powell LW, et al. Lancet. 2016;388:706-716. Rametta R, et al. Int J Mol Sci. 2020;21:3505. Sella EJ, Goodman AH. J Bone Joint Surg Am. 1973;55:1077-1081. Sutton M. Internet Journal of Criminology. 2010;1-34.

In this episode, we explore the ins and outs of exercise and brain-derived neurotrophic factor (BDNF), which is integral to memory, nerve growth, memory, learning, and memory; did we say that already? Our special guest this week is exercise physiology PhD candidate Greg Spicer whose dissertation focuses on exercise modalities and acute cardiovascular and neurological responses, including BDNF. All content provided in ExPhysCast is to be considered as educational and speculation. Nothing discussed in ExPhysCast should be considered medical advice. If you have any medical questions, please speak to your primary care provider. Papers discussed: Arazi H, Babaei P, Moghimi M, Asadi A. Acute effects of strength and endurance exercise on serum BDNF and IGF-1 levels in older men. BMC Geriatrics, 2021;21(50):1-8. Garcia-Suarez PC, Renetria I, Moncada-Jimenez J, Fry AC, Jimenez-Maldonado A. Acute systemic response of BDNF, lactate and cortisol to strenuous exercise modalities in healthy untrained women. Dose-Response: An International Journal, 2020;18(44). Other recommended reading: De Assis GG, de Almondes KM. Exercise-dependent BDNF as a modulatory factor for the executive processing of individuals in course of cognitive decline. A systematic review. Frontiers in Psychopathology, 2017;8:584. Rozanska O, Uruska A, Zozulinska-Ziolkiewicz. Brain-derived neurotrophic factor and diabetes. Int J Mol Sci,. 2020;21(3):841. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/luke-pelton/support

In this episode, we dig into hemochromatosis to better understand what it is, how it affects the joints, available screening methods, as well as clues to presentation and physical exam findings. Brought to you by GSK. Intro :10 Today’s episode :26 What is hemochromatosis? 1:42 What does the iron do? 3:03 How much iron is in the body? 5:30 When do you suspect it? 7:46 What do we want to know about the joints? 9:33 About Ralph Schumacher Jr., MD, and his work 12:15 How have Schumacher’s observations held up? 14:42 What about radiographs … can they help? 16:09 What about hand OA and the gene mutation? 16:44 So, what about people with undiagnosed hemochromatosis? What do their hands look like? 18:09 What about chondrocalcinosis? 19:13 Tune in next time for part two 21:59 Episode wrap-up 22:25 Disclosures: Brown reports no relevant financial disclosures. We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum References: Bulaj ZJ, et al. N Engl J Med. 2000;343:1529-1535. Carroll GJ, et al. Arthritis Care Res. 2012;64:9-14. Hamilton EB, et al. Q J Med 1981;199:321–329. Jordan JM. Curr Opin Rheumatol. 2004;16:62-66. Rametta R, et al. Int J Mol Sci. 2020;21:3505. Ross JM, et al. J Rheumatol. 2003;30:121-5. Schumacher HR. Arthritis Rheum. 1964;7:41–50. Timms AE, et al. Ann Rheum Dis. 2002;61:745–747. Ulvik RJ. Tidsskr Nor Laegeforen. 2016;136:2017-2021.

Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease. Wu PH, Kim HS, Jang IT. Int J Mol Sci. 2020 Mar 20;21(6):2135. doi: 10.3390/ijms21062135. PMID: 32244936 --- Send in a voice message: https://anchor.fm/moveman/message

References 1. Ota Y, Connolly M, Srinivasan A, Kim J, Capizzano AA, Moritani T. Mechanisms and Origins of Spinal Pain: from Molecules to Anatomy, with Diagnostic Clues and Imaging Findings. Radiographics. 2020;40(4):1163-81.2. Lotz JC, Haughton V, Boden SD, An HS, Kang JD, Masuda K, et al. New treatments and imaging strategies in degenerative disease of the intervertebral disks. Radiology. 2012;264(1):6-19.3. Theodorou DJ, Theodorou SJ, Kakitsubata S, Nabeshima K, Kakitsubata Y. Abnormal Conditions of the Diskovertebral Segment: MRI With Anatomic-Pathologic Correlation. AJR Am J Roentgenol. 2020;214(4):853-61.4. HS K. Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature. Int J Mol Sci. 2020;21:1483.5. Hughes RJ, Saifuddin A. Numbering of lumbosacral transitional vertebrae on MRI: role of the iliolumbar ligaments. AJR Am J Roentgenol. 2006;187(1):W59-65.6. K C. A Concise Introduction to the Imaging of the Lumbar Spine2016.7. Fardon DF, Williams AL, Dohring EJ, Murtagh FR, Gabriel Rothman SL, Sze GK. Lumbar disc nomenclature: version 2.0: Recommendations of the combined task forces of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology. Spine J. 2014;14(11):2525-45.8. Kushchayev SV, Glushko T, Jarraya M, Schuleri KH, Preul MC, Brooks ML, et al. ABCs of the degenerative spine. Insights Imaging. 2018;9(2):253-74.9. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 2001;26(17):1873-8.10. M B. MRI Degenerative Disease of the Lumbar Spine. J Am Osteopath Coll Radiol. 2018.11. Yu LP, Qian WW, Yin GY, Ren YX, Hu ZY. MRI assessment of lumbar intervertebral disc degeneration with lumbar degenerative disease using the Pfirrmann grading systems. PLoS One. 2012;7(12):e48074.12. KS T. Imaging of Spinal Stenosis. Applied Radiology. 2017.13. Carlson BB, Albert TJ. Lumbar disc herniation: what has the Spine Patient Outcomes Research Trial taught us? Int Orthop. 2019;43(4):853-9.14. Pfirrmann CW, Dora C, Schmid MR, Zanetti M, Hodler J, Boos N. MR image-based grading of lumbar nerve root compromise due to disk herniation: reliability study with surgical correlation. Radiology. 2004;230(2):583-8.15. Gallucci M, Puglielli E, Splendiani A, Pistoia F, Spacca G. Degenerative disorders of the spine. Eur Radiol. 2005;15(3):591-8.16. Mamisch N, Brumann M, Hodler J, Held U, Brunner F, Steurer J, et al. Radiologic criteria for the diagnosis of spinal stenosis: results of a Delphi survey. Radiology. 2012;264(1):174-9.17. N H. The "ABCDE" Approach to the Systematic Assessment of Lumbar Spine MR Examination. CDR. 2020.18. Zileli M, Crostelli M, Grimaldi M, Mazza O, Anania C, Fornari M, et al. Natural Course and Diagnosis of Lumbar Spinal Stenosis: WFNS Spine Committee Recommendations. World Neurosurg X. 2020;7:100073.19. Cho IY, Park SY, Park JH, Suh SW, Lee SH. MRI findings of lumbar spine instability in degenerative spondylolisthesis. J Orthop Surg (Hong Kong). 2017;25(2):2309499017718907.20. Semaan H, Curnutte B, Cooper M, Obri J, Elsamaloty M, Obri T, et al. Overreporting of the disc herniation in lumbar spine MRI scans performed for patients with spondylolisthesis. Acta Radiol. 2020:284185120925483.21. GC G. Lumbar Spine Imaging: MRI. 2017.

References 1. Ota Y, Connolly M, Srinivasan A, Kim J, Capizzano AA, Moritani T. Mechanisms and Origins of Spinal Pain: from Molecules to Anatomy, with Diagnostic Clues and Imaging Findings. Radiographics. 2020;40(4):1163-81.2. Lotz JC, Haughton V, Boden SD, An HS, Kang JD, Masuda K, et al. New treatments and imaging strategies in degenerative disease of the intervertebral disks. Radiology. 2012;264(1):6-19.3. Theodorou DJ, Theodorou SJ, Kakitsubata S, Nabeshima K, Kakitsubata Y. Abnormal Conditions of the Diskovertebral Segment: MRI With Anatomic-Pathologic Correlation. AJR Am J Roentgenol. 2020;214(4):853-61.4. HS K. Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature. Int J Mol Sci. 2020;21:1483.5. Hughes RJ, Saifuddin A. Numbering of lumbosacral transitional vertebrae on MRI: role of the iliolumbar ligaments. AJR Am J Roentgenol. 2006;187(1):W59-65.6. K C. A Concise Introduction to the Imaging of the Lumbar Spine2016.7. Fardon DF, Williams AL, Dohring EJ, Murtagh FR, Gabriel Rothman SL, Sze GK. Lumbar disc nomenclature: version 2.0: Recommendations of the combined task forces of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology. Spine J. 2014;14(11):2525-45.8. Kushchayev SV, Glushko T, Jarraya M, Schuleri KH, Preul MC, Brooks ML, et al. ABCs of the degenerative spine. Insights Imaging. 2018;9(2):253-74.9. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 2001;26(17):1873-8.10. M B. MRI Degenerative Disease of the Lumbar Spine. J Am Osteopath Coll Radiol. 2018.11. Yu LP, Qian WW, Yin GY, Ren YX, Hu ZY. MRI assessment of lumbar intervertebral disc degeneration with lumbar degenerative disease using the Pfirrmann grading systems. PLoS One. 2012;7(12):e48074.12. KS T. Imaging of Spinal Stenosis. Applied Radiology. 2017.13. Carlson BB, Albert TJ. Lumbar disc herniation: what has the Spine Patient Outcomes Research Trial taught us? Int Orthop. 2019;43(4):853-9.14. Pfirrmann CW, Dora C, Schmid MR, Zanetti M, Hodler J, Boos N. MR image-based grading of lumbar nerve root compromise due to disk herniation: reliability study with surgical correlation. Radiology. 2004;230(2):583-8.15. Gallucci M, Puglielli E, Splendiani A, Pistoia F, Spacca G. Degenerative disorders of the spine. Eur Radiol. 2005;15(3):591-8.16. Mamisch N, Brumann M, Hodler J, Held U, Brunner F, Steurer J, et al. Radiologic criteria for the diagnosis of spinal stenosis: results of a Delphi survey. Radiology. 2012;264(1):174-9.17. N H. The "ABCDE" Approach to the Systematic Assessment of Lumbar Spine MR Examination. CDR. 2020.18. Zileli M, Crostelli M, Grimaldi M, Mazza O, Anania C, Fornari M, et al. Natural Course and Diagnosis of Lumbar Spinal Stenosis: WFNS Spine Committee Recommendations. World Neurosurg X. 2020;7:100073.19. Cho IY, Park SY, Park JH, Suh SW, Lee SH. MRI findings of lumbar spine instability in degenerative spondylolisthesis. J Orthop Surg (Hong Kong). 2017;25(2):2309499017718907.20. Semaan H, Curnutte B, Cooper M, Obri J, Elsamaloty M, Obri T, et al. Overreporting of the disc herniation in lumbar spine MRI scans performed for patients with spondylolisthesis. Acta Radiol. 2020:284185120925483.21. GC G. Lumbar Spine Imaging: MRI. 2017.

References 1. Ota Y, Connolly M, Srinivasan A, Kim J, Capizzano AA, Moritani T. Mechanisms and Origins of Spinal Pain: from Molecules to Anatomy, with Diagnostic Clues and Imaging Findings. Radiographics. 2020;40(4):1163-81.2. Lotz JC, Haughton V, Boden SD, An HS, Kang JD, Masuda K, et al. New treatments and imaging strategies in degenerative disease of the intervertebral disks. Radiology. 2012;264(1):6-19.3. Theodorou DJ, Theodorou SJ, Kakitsubata S, Nabeshima K, Kakitsubata Y. Abnormal Conditions of the Diskovertebral Segment: MRI With Anatomic-Pathologic Correlation. AJR Am J Roentgenol. 2020;214(4):853-61.4. HS K. Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature. Int J Mol Sci. 2020;21:1483.5. Hughes RJ, Saifuddin A. Numbering of lumbosacral transitional vertebrae on MRI: role of the iliolumbar ligaments. AJR Am J Roentgenol. 2006;187(1):W59-65.6. K C. A Concise Introduction to the Imaging of the Lumbar Spine2016.7. Fardon DF, Williams AL, Dohring EJ, Murtagh FR, Gabriel Rothman SL, Sze GK. Lumbar disc nomenclature: version 2.0: Recommendations of the combined task forces of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology. Spine J. 2014;14(11):2525-45.8. Kushchayev SV, Glushko T, Jarraya M, Schuleri KH, Preul MC, Brooks ML, et al. ABCs of the degenerative spine. Insights Imaging. 2018;9(2):253-74.9. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 2001;26(17):1873-8.10. M B. MRI Degenerative Disease of the Lumbar Spine. J Am Osteopath Coll Radiol. 2018.11. Yu LP, Qian WW, Yin GY, Ren YX, Hu ZY. MRI assessment of lumbar intervertebral disc degeneration with lumbar degenerative disease using the Pfirrmann grading systems. PLoS One. 2012;7(12):e48074.12. KS T. Imaging of Spinal Stenosis. Applied Radiology. 2017.13. Carlson BB, Albert TJ. Lumbar disc herniation: what has the Spine Patient Outcomes Research Trial taught us? Int Orthop. 2019;43(4):853-9.14. Pfirrmann CW, Dora C, Schmid MR, Zanetti M, Hodler J, Boos N. MR image-based grading of lumbar nerve root compromise due to disk herniation: reliability study with surgical correlation. Radiology. 2004;230(2):583-8.15. Gallucci M, Puglielli E, Splendiani A, Pistoia F, Spacca G. Degenerative disorders of the spine. Eur Radiol. 2005;15(3):591-8.16. Mamisch N, Brumann M, Hodler J, Held U, Brunner F, Steurer J, et al. Radiologic criteria for the diagnosis of spinal stenosis: results of a Delphi survey. Radiology. 2012;264(1):174-9.17. N H. The "ABCDE" Approach to the Systematic Assessment of Lumbar Spine MR Examination. CDR. 2020.18. Zileli M, Crostelli M, Grimaldi M, Mazza O, Anania C, Fornari M, et al. Natural Course and Diagnosis of Lumbar Spinal Stenosis: WFNS Spine Committee Recommendations. World Neurosurg X. 2020;7:100073.19. Cho IY, Park SY, Park JH, Suh SW, Lee SH. MRI findings of lumbar spine instability in degenerative spondylolisthesis. J Orthop Surg (Hong Kong). 2017;25(2):2309499017718907.20. Semaan H, Curnutte B, Cooper M, Obri J, Elsamaloty M, Obri T, et al. Overreporting of the disc herniation in lumbar spine MRI scans performed for patients with spondylolisthesis. Acta Radiol. 2020:284185120925483.21. GC G. Lumbar Spine Imaging: MRI. 2017.

References 1. Ota Y, Connolly M, Srinivasan A, Kim J, Capizzano AA, Moritani T. Mechanisms and Origins of Spinal Pain: from Molecules to Anatomy, with Diagnostic Clues and Imaging Findings. Radiographics. 2020;40(4):1163-81.2. Lotz JC, Haughton V, Boden SD, An HS, Kang JD, Masuda K, et al. New treatments and imaging strategies in degenerative disease of the intervertebral disks. Radiology. 2012;264(1):6-19.3. Theodorou DJ, Theodorou SJ, Kakitsubata S, Nabeshima K, Kakitsubata Y. Abnormal Conditions of the Diskovertebral Segment: MRI With Anatomic-Pathologic Correlation. AJR Am J Roentgenol. 2020;214(4):853-61.4. HS K. Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature. Int J Mol Sci. 2020;21:1483.5. Hughes RJ, Saifuddin A. Numbering of lumbosacral transitional vertebrae on MRI: role of the iliolumbar ligaments. AJR Am J Roentgenol. 2006;187(1):W59-65.6. K C. A Concise Introduction to the Imaging of the Lumbar Spine2016.7. Fardon DF, Williams AL, Dohring EJ, Murtagh FR, Gabriel Rothman SL, Sze GK. Lumbar disc nomenclature: version 2.0: Recommendations of the combined task forces of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology. Spine J. 2014;14(11):2525-45.8. Kushchayev SV, Glushko T, Jarraya M, Schuleri KH, Preul MC, Brooks ML, et al. ABCs of the degenerative spine. Insights Imaging. 2018;9(2):253-74.9. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 2001;26(17):1873-8.10. M B. MRI Degenerative Disease of the Lumbar Spine. J Am Osteopath Coll Radiol. 2018.11. Yu LP, Qian WW, Yin GY, Ren YX, Hu ZY. MRI assessment of lumbar intervertebral disc degeneration with lumbar degenerative disease using the Pfirrmann grading systems. PLoS One. 2012;7(12):e48074.12. KS T. Imaging of Spinal Stenosis. Applied Radiology. 2017.13. Carlson BB, Albert TJ. Lumbar disc herniation: what has the Spine Patient Outcomes Research Trial taught us? Int Orthop. 2019;43(4):853-9.14. Pfirrmann CW, Dora C, Schmid MR, Zanetti M, Hodler J, Boos N. MR image-based grading of lumbar nerve root compromise due to disk herniation: reliability study with surgical correlation. Radiology. 2004;230(2):583-8.15. Gallucci M, Puglielli E, Splendiani A, Pistoia F, Spacca G. Degenerative disorders of the spine. Eur Radiol. 2005;15(3):591-8.16. Mamisch N, Brumann M, Hodler J, Held U, Brunner F, Steurer J, et al. Radiologic criteria for the diagnosis of spinal stenosis: results of a Delphi survey. Radiology. 2012;264(1):174-9.17. N H. The "ABCDE" Approach to the Systematic Assessment of Lumbar Spine MR Examination. CDR. 2020.18. Zileli M, Crostelli M, Grimaldi M, Mazza O, Anania C, Fornari M, et al. Natural Course and Diagnosis of Lumbar Spinal Stenosis: WFNS Spine Committee Recommendations. World Neurosurg X. 2020;7:100073.19. Cho IY, Park SY, Park JH, Suh SW, Lee SH. MRI findings of lumbar spine instability in degenerative spondylolisthesis. J Orthop Surg (Hong Kong). 2017;25(2):2309499017718907.20. Semaan H, Curnutte B, Cooper M, Obri J, Elsamaloty M, Obri T, et al. Overreporting of the disc herniation in lumbar spine MRI scans performed for patients with spondylolisthesis. Acta Radiol. 2020:284185120925483.21. GC G. Lumbar Spine Imaging: MRI. 2017.