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Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Drone Guy Ben joins us to discuss new waves, sharks and meta glassses.       For our listeners: Varsity Sports Bar! https://www.varsity.com.au   20% off Rusty TradeR work wear use code: TRADER20GRINREAPERS at www.rusty.com.au/traderworkwear 25% off New Rusty wetsuits  - use code: GRINREAPERS25 at www.rusty.com.au/wetsuits Rusty Locals Only: https://rusty.com.au/collections/locals-only   Support: https://www.patreon.com/ChrisWhitey https://www.patreon.com/BrianShields Other Links:  https://www.instagram.com/chris.whitey https://www.instagram.com/brianshields_ https://www.instagram.com/grin_reapers https://www.facebook.com/GrinReapersMedia/ Web:  www.tensionmovies.com https://itunes.apple.com/au/podcast/the-grin-reapers-podcast/id1380019049

THE CORAL – Let The Music Play OF MONTREAL – Already Dreaming GHINZU – Snow White THE BUG CLUB – How Can We Be Friends ? THE BUG CLUB – It’s Our Manager David EDDY CURRENT SUPPRESSION RING – Self Sabotage ANADOL & MARIE KLOCK – Magnitude 6.3 TY – Get Knocked Out PIL – This Is Not A Love Song HOLY WAVE – s33.u.in/HAL FINN WOLFHARD – I’ll Let You Finish PANIC SHACK – Grin & Gear It WESTSIDE COWBOYS – Kick Stones (The Boys)

Huma joins us to chat about Shark Island, seal attacks, UFO's, new waves and much more!

Hey there Grin….wait a minute! It’s not Stoner Movie September?! What is this? Bryan picked for this week a movie all about getting down two flights of stairs to get some pizza. On drugs. With your head exploding. Idk man, but this sure seems like a Stoner Movie to me. Sit down, buckle up, feed your pet butterfly, and hang out with the boys as they talk about “Pizza Movie.” If you enjoyed this and would like more, please head on over to our Patreon to hear more bonus episodes, available (usually) weekly!  Additional links to that or our Discord can be found right on our Website!

Every Legend has its MakingHosted on Ausha. See ausha.co/privacy-policy for more information.

A big few weeks of UFC, Comedy, Boog, Surf and Run.

Middle of the week and we meet a Pantera Tribute band called Black Tooth Grin with Julian Sklar. Songs include Cowboys From Hell, Drags the Water and Domination/Hollow

Send us Fan MailJoin me as I welcome Aigaras Stewart, a.k.a. Kook Grin to the Small Truck Campers podcast.  In this episode we dive deep into his origins, early life on the road and hilarious (in retrospect) disasters.  We talk about his early graphic designs, the struggle to move and eventually live in Colorado, and more recently his passion of building simple and functional flatbeds for trucks. This is the most hysterical episode I have recored, so grab your favorite campfire beverage and lets hit the road!If you arent already, follow Aigaras on Instagram HERE!Support the showSpecial Thanks to our Supporters of the community:Capri Campers- Everything you need- Check them HERE!I got my Kermit Camp Chair and I love it- Check them out!Shop all the STC Merch here, and support the channel!For the Small Truck Campers website, click here!To check out our Instagram, click here!For our YouTube Channel, click here!Join our Facebook Group here!

In this episode, we talk with ophthalmologist Dr. Jennifer Grin about a practical, high-yield approach to evaluating eye complaints, documenting findings, and knowing when to urgently refer. The conversation covers a breakdown of an “easy eye exam” any clinician can do from starting with visual acuity as the eye's vital sign to realistic expectations for the fundus exam. Dr. Grin reviews warning signs such as sudden vision loss, abnormal pupils, flashes/floaters with a curtain (retinal detachment), and concerning trauma. She also highlights common pitfalls like mislabeling serious diseases like conjunctivitis, missing open globe injuries, and prescribing topical steroids or anesthetics without a clear diagnosis. Feedback or episode ideas email the show at wnlpodcast@copic.comDisclaimer: Information provided in this podcast should not be relied upon for personal, medical, legal, or financial decisions and you should consult an appropriate professional for specific advice that pertains to your situation. Health care providers should exercise their professional judgment in connection with the provision of healthcare services. The information contained in this podcast is not intended to be, nor is it, a substitute for medical diagnosis, treatment, advice, or judgment relative to a patient's specific condition.

Keep pinging the Carnt. UFC, Comedy, Fitness, MMA we cover it all.   For our listeners: Varsity Sports Bar! https://www.varsity.com.au   20% off Rusty TradeR work wear use code: TRADER20GRINREAPERS at www.rusty.com.au/traderworkwear 25% off New Rusty wetsuits  - use code: GRINREAPERS25 at www.rusty.com.au/wetsuits Rusty Locals Only: https://rusty.com.au/collections/locals-only   Support: https://www.patreon.com/ChrisWhitey https://www.patreon.com/BrianShields Other Links:  https://www.instagram.com/chris.whitey https://www.instagram.com/brianshields_ https://www.instagram.com/grin_reapers https://www.facebook.com/GrinReapersMedia/ Web:  www.tensionmovies.com https://itunes.apple.com/au/podcast/the-grin-reapers-podcast/id1380019049

We're Duscher-less this week but we're joined by George and Demi from Grin and Dandy to help answer another incredible pop culture question. This time we're going back in time with only the information contained within our rotten brains to try and exploit those past-os for personal profit or financial gain. The only problem is we aren't clever nor do we retain information well. Zammit tries a harebrained scheme to invent the wheel but gets too caught up in coconuts and doesn't fundamentally understand how wheels work, Jackson wants to domesticate dogs early and wants to immediately break the rules and bring back a dog, George has a brilliant idea to make a cult and Demi wants to bring back an ear worm which made Zammit think of that horrible film he hates Yesterday so changes his answer to ensuring that he Yesterdays Yesterday.If you're in Melbourne for the Melbourne International Film Festival, be sure to check out Grin and Dandy! Check out their website https://grinanddandy.com or follow them on instagram.com/grinanddandy xx o.Links to everything at https://linktr.ee/plumbingthedeathstar including our terrible merch, social media garbage and where to become a subscriber to Bad Brain Boys+ Hosted on Acast. See acast.com/privacy for more information.

durée : 00:05:59 - Le Masque et la Plume - par : Jérôme Garcin - Le quatrième long-métrage du duo Nicolas et Bruno débarque sur les écrans avec une promesse alléchante : Laurent Lafitte dans deux rôles, face à lui-même. Qu'en ont pensé les critiques cinéma du Masque et la plume ? Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

She Introduced Me As 'Just A Friend' At The Reception Table And All I Could Do Was GrinBecome a supporter of this podcast: https://www.spreaker.com/podcast/true-cheating-wives-and-girlfriends-stories-2026-true-cheating-stories-podcast--5689182/support.

We're back! New year, new jobs, new cars, new stories new Reapers baby!!   For our listeners: Varsity Sports Bar! https://www.varsity.com.au   20% off Rusty TradeR work wear use code: TRADER20GRINREAPERS at www.rusty.com.au/traderworkwear 25% off New Rusty wetsuits  - use code: GRINREAPERS25 at www.rusty.com.au/wetsuits Rusty Locals Only: https://rusty.com.au/collections/locals-only Use code: REAPERS at https://au.manscaped.com/ for 20% discount Support: https://www.patreon.com/ChrisWhitey https://www.patreon.com/BrianShields Other Links:  https://www.instagram.com/chris.whitey https://www.instagram.com/brianshields_ https://www.instagram.com/grin_reapers https://www.facebook.com/GrinReapersMedia/ Web:  www.tensionmovies.com https://itunes.apple.com/au/podcast/the-grin-reapers-podcast/id1380019049

The Familiar GrinBecome a supporter of this podcast: https://www.spreaker.com/podcast/darkest-mysteries-online-the-strange-and-unusual-podcast-2026--5684156/support.Darkest Mysteries Online

Phil Nadel is a well-respected serial entrepreneur, venture capital investor, mentor,published author and frequent speaker at industry events and business schools. Hehas started and sold several companies and has invested more than $400M in morethan 200 startups including Grove Collaborative, Calm,Boundless, Havenly,and GRIN.

In this episode of Mastering eCommerce Marketing, host Eitan Koter sits down with Megan Vasquez, Director of Creator Strategy and Strategic Marketing at Grin.Megan shares what she has learned from working across beauty brands, agencies, and large e-commerce companies. Creator marketing is no longer a side project. It is expected to deliver results.They cover how to forecast revenue from influencers, how to align campaign goals with the right creators, and why reducing friction in the buying process makes a big difference.Megan also talks about TikTok Shop, affiliate strategy, and the importance of long term creator relationships.If you want a clearer view of how creator marketing drives sales today, this episode is worth listening to.Website: https://www.vimmi.netEmail us: info@vimmi.netPodcast website: https://vimmi.net/mastering-ecommerce-marketing/Talk to us on Social:Eitan Koter's LinkedIn | Vimmi LinkedIn | YouTubeGuest: Megan Vasquez, Director of Creator Strategy & Strategic Marketing at GRINMegan Vasquez's LinkedIn | GRINWatch the full Youtube video here:https://youtu.be/4J9Dit-kIC4Takeaways:The creator economy is evolving and growing rapidly.Data-driven marketing is essential for success in the creator space.AI can help streamline processes and enhance creativity.TikTok has revolutionized e-commerce and product discovery.Brands must focus on building authentic relationships with creators.Neglecting brand affinity can lead to poor performance in campaigns.Long-term contracts with creators foster trust and better results.Clicks and audience sentiment are crucial KPIs for campaigns.User-generated content often outperforms traditional marketing.Grin is focused on meeting market needs with innovative solutions.Chapters:00:00 Introduction to the Creator Economy02:29 The Evolution of the Creator Economy05:18 Data-Driven Marketing in the Creator Space08:14 Balancing Self-Service and Hand-Holding in SaaS11:08 The Role of AI in Marketing and Content Creation13:49 The Impact of TikTok on Social Shopping16:45 Common Mistakes in Creator Programs19:49 Building Long-Term Relationships with Creators22:47 Key Performance Indicators for Campaign Success25:26 Future Plans for Grin and the Creator Economy

VOV1 - Hôm nay (13/2), tại Đức khai mạc hội nghị An ninh Munich 2026 với sự tham dự của hơn 100 nguyên thủ quốc gia, bộ trưởng quốc phòng và ngoại giao.Trong bối cảnh những chia rẽ, rạn nứt sâu sắc trong mối quan hệ đồng minh xuyên Đại Tây Dương giữa Mỹ và châu Âu, hội nghị lần này được cho sẽ bàn thảo về vấn đề “tự chủ chiến lược” nhằm củng cố sức mạnh nội tại và định vị lại vị thế của châu Âu.Sự lệch pha rõ rệt giữa Mỹ và Liên minh châu Âu từ vấn đề quốc phòng, thuế quan, xung đột tại Ucraina, cho đến vấn đề Grin-len khiến châu Âu buộc phải thẳng thắn đối diện với những rủi ro của sự phụ thuộc. Tại hội nghị An ninh Munich 2026, bài toán “tự chủ chiến lược” sẽ được các nước châu Âu tính toán ra sao?Ảnh minh họa

We're LIVE again from Williamsburg, VA at the 2026 Last Word Comedy Festival! This year, we looked to fiber-rich comedy major Li for inspiration for an all-new fully improvised musical. Copious carrots, vicarious villains, tasty transformations, and more on this week's Charm Scene! What's up, Doc? Special thanks to the city of Williamsburg for sponsoring the event, and to everyone at The Last Word Comedy Festival. Learn more at lastwordfestival.com Recorded January 29, 2026 at PBK Hall at The College of William and Mary Cast: Lily Ludwig, Austin Packard, with introduction by Adam Stackhouse Music Director: Sam Scheidler Follow us @CharmScenePod on Instagram and YouTube, or shoot us a message at CharmScenePod@gmail.com!

You Can Follow Megan here:Website: https://grin.co/LinkedIn: https://www.linkedin.com/company/grin-inc- Personal LinkedIn: https://www.linkedin.com/in/megvas/Today on Influencer Confidential, I'm sitting down with Megan Vasquez from GRIN, a true OG in the creator economy who's worked brand-side, agency-side, talent-side, and now in tech. We talk about how brands actually discover creators, what's happening behind the scenes when brands are scrolling Instagram on desktop, and why things like consistency, your bio, and having your email visible matter more than most creators realize.We also dive into where the industry is headed, why long-term partnerships are becoming the norm, how affiliate and hybrid deals are evolving, and what brands are really prioritizing when it comes to ROI.Plus, we touch on brand safety, transparency, and whether AI is actually a threat or just a tool to make everyone's lives easier. If you've ever wanted a real look behind the curtain from the brand side, this episode is for you.You can connect with Megan on her LinkedIn here: https://www.linkedin.com/in/megvas/::::Sidewalker Daily is your go-to resource for Creators and Influencers who want to land paid brand deals, make money doing what they love, and build a successful business with the right tools and strategies.

Ryan Debenham, CEO of Grin, shares his unconventional journey from software engineer to leading a nearly billion-dollar creator management platform. In this candid conversation, Ryan reveals how he "accidentally" became a CEO by following challenges rather than titles, and why that mindset shift transformed how he builds products and companies.He discusses the critical disconnect between engineering and go-to-market teams, the revolutionary potential of AI agents in influencer marketing, and why democratizing influence could unlock a massive untapped market. Ryan also shares insights from his time at Qualtrics (acquired by SAP for $8B) and Route, offering practical wisdom on connecting product teams to revenue outcomes and building AI that feels "alive."Key Takeaways[4:30] - The Accidental CEO Path: Ryan explains how becoming a CEO was never his plan—he loved building products but never built companies around them. His career evolved by chasing challenges rather than titles or money.[10:30] - The Product-to-Company Graveyard: Ryan candidly shares how his early product ideas (including a ride-sharing concept 20 years ago and a photo categorization tool) died because he focused only on building, not on solving the hard business problems.[12:15] - The Mindset Shift: The biggest change from engineering to CEO? When revenue numbers became Ryan's responsibility, he finally understood what customers truly needed—not just what they said they wanted.[14:30] - Breaking Down Silos: Ryan discusses why the tension between product, engineering, marketing, and sales "will kill the business" and how he's connecting these departments at the hip.[19:30] - The Qualtrics Lesson: A powerful story about spending six months building the wrong text analytics product at Qualtrics, despite sitting next to customers repeatedly. The lesson: understanding business needs requires deeper connection than just listening to feature requests.[26:00] - AI as Electricity: Ryan's compelling analogy comparing LLMs to the development of electricity and CPUs—powerful building blocks that are worthless alone but transformational when paired with the right infrastructure.[28:30] - Mandatory AI Adoption: Ryan required all engineers at Grin to use AI coding tools. One engineer quit over the pressure but came back, realizing it was a mistake. His prediction: in a few years, you won't get hired as an engineer if you don't know AI tools.[32:00] - Building Software That's "Alive": Ryan describes Gia, Grin's AI agent that journals daily, runs standups with other agents, creates action items, and can discuss what she's learning and what features should be built next.[35:00] - The Influencer Marketing Problem: Why Grin's growth stalled—aspirational customers bought the software but failed at influencer marketing because the operational complexity was too high, leading to churn.[38:30] - The Two-Sided Platform Gap: Most influencer platforms built for merchants and forgot creators. Ryan explains why supporting creators is the most important part of the solution.[44:30] - Democratizing Influence: Ryan's vision that "everybody is an influencer"—the real opportunity is capturing and rewarding the micro-influence that happens in everyday conversations between millions of people.[49:00] - The Collision Course: Why affiliate marketing and influencer marketing are merging into something new—it's all about capturing word-of-mouth at different scales.Tweetable...

VOV1 - Tổng thống Mỹ  Đô-nan Trăm (Donald Trump) hôm qua bất ngờ rút lại lời đe dọa áp thuế đối với 8 quốc gia châu Âu, đánh dấu sự đảo chiều đáng chú ý trong cuộc đối đầu xoay quanh vấn đề Grin-len (Greenland).

Side B is where the spotlight turns to the Mr VicBears 2026 competition — and the humans brave enough to step into it. In this half of Episode 222, Hide and Seek meets the Class of '26: Teddy, Justin, Ray, Jake and Craig. It's a line-up full of history, heart, camp, nerves, confidence, and wildly different journeys into the bear community. Each competitor shares how they found the bears, what keeps them coming back, and why they've decided to run for the sash. We talk community advocacy, representation, confidence-building, favourite '90s films (yes, Clueless and Serial Mom both feature), and the very real mix of excitement and terror that comes with putting yourself out there. This isn't just about abs, beards, or who owns the most outfits with paw prints. It's about visibility, approachability, and what it means to represent a community built on belonging rather than perfection. From long-time committee members to returning competitors and first-time entrants, the Class of '26 reflects the diversity and generosity of the bear scene itself. Side B is funny, warm, occasionally awkward, and deeply sincere — a reminder that while only one person gets the sash, the real win is showing up, being seen, and strengthening the community along the way. The competitors each highlighted a charity for their runs: Teddy spoke about Switchboard Justin threw behind the Australian Queer Archives Ray highlighted Transgender Victoria Jake talked up QLife and Craig covered Out of the Closet, Out of Options Follow Tim instagram.com/beatzradio/ Follow Jon instagram.com/barbarylion/ Follow Craig instagram.com/white.dragon.339/ This episode was recorded on the lands of the Yalukut Weelam clan of the Boon Wurrung peoples. We pay our respects to their elders, past, present and emerging, and acknowledge that sovereignty was never ceded. Find other JOY podcasts at joy.org.au

During Midsumma each year, Victoria doesn't just come out — it comes out hairy. In Side A of Episode 222, we grin and bear it as Hide and Seek dives into BearFest 2026, the week-long celebration of bears, admirers, community, and controlled chaos that takes over Melbourne every summer. Jon, Craig and Joenas are joined by Neil of the VicBears committee to unpack what the bear scene actually is (and isn't), how it grew in Australia, and why it continues to matter far beyond the dance floor. We talk chosen family, intergenerational connection, accessibility, body diversity, and why bear spaces often feel like home for people who never quite fit elsewhere. Then we take a deep, slightly breathless tour through the week itself: BearWatch Beach Day at Williamstown, Midsumma Carnival, the Teddy Bear Banquet, Bearaoke (where dignity goes to die), Underbear nights, pool parties, dance floors, Pride March prep, and everything in between. Sunscreen, hydration, and sensible footwear are strongly encouraged. Along the way, we share stories, laughs, and a few “how did we survive that?” moments — because BearFest isn't just a series of events, it's a social ecosystem powered by volunteers, community care, and an impressive tolerance for late nights. Whether you're a seasoned bear, bear-adjacent, or just wondering why your friends suddenly own harnesses and towels, Side A is your affectionate guide to BearFest — and the people who make it roar. Love a bear comp? Listen to Who Bears Wins and hear Joenas when he first won his title! Follow Tim instagram.com/beatzradio/ Follow Jon instagram.com/barbarylion/ Follow Craig instagram.com/white.dragon.339/ This episode was recorded on the lands of the Yalukut Weelam clan of the Boon Wurrung peoples. We pay our respects to their elders, past, present and emerging, and acknowledge that sovereignty was never ceded. Find other JOY podcasts at joy.org.au

- Thủ tướng Chính phủ phê duyệt Chương trình hỗ trợ pháp lý liên ngành cho doanh nghiệp nhỏ và vừa, hộ kinh doanh giai đoạn 2026 - 2030.- Việt Nam giành 3 Giải thưởng Số ASEAN 2026.- Ngư dân Quảng Trị sắp xếp chuyến biển, hướng về ngày hội bầu cử toàn dân 15/3/2026.- Bộ phim "Mưa đỏ" giành 3 giải thưởng quan trọng tại Lễ trao giải Cánh diều 2025 của Hội Điện ảnh Việt Nam.-  Việc châu Âu gửi các binh sỹ tới Grin-len sẽ không ảnh hưởng đến quyết định của Tổng thống Mỹ Donald Trump liên quan đến vùng lãnh thổ này của Đan Mạch.- Hamas sẵn sàng chuyển giao quyền lực tại Gaza cho Ủy ban kỹ trị Palestine.- Cũng trong chương trình sáng nay, BTV Đài TNVN có bình luận với nhan đề "Chiến dịch Quang Trung: Phép thử về năng lực điều hành, về kỷ luật hành chính và tinh thần trách nhiệm".

- Phiên họp thứ 53 của Ủy ban Thường vụ Quốc hội sẽ xem xét và thông qua hai nghị quyết liên quan đến chế độ trang phục, phù hiệu và cơ cấu ngạch Kiểm sát viên.- Thành phố Hồ Chí Minh sẽ khởi công hàng loạt dự án hạ tầng, giao thông chiến lược vào ngày 15/1.- Năm 2025, Việt Nam xuất khẩu hơn 8 triệu tấn gạo, thu về trên 4 tỷ 100 triệu đô la Mỹ.- Từ ngày 30/6/2026, Bộ Xây dựng triển khai kiểm định khí thải mô tô, xe gắn máy trên toàn quốc nhằm kiểm soát ô nhiễm không khí.- Các nước châu Âu và Canada đồng loạt phản đối việc Mỹ “nhòm ngó” Grin-len, vùng lãnh thổ tự trị thuộc Vương quốc Đan Mạch.- Thảm đỏ Hollywood sôi động trước thềm lễ trao giải Quả cầu Vàng 2026, sự kiện mở màn mùa giải thưởng điện ảnh, hướng tới Oscar vào tháng 3 tới.

- Chủ trì Hội nghị triển khai phương hướng, nhiệm vụ năm 2026 của Ban Chấp hành Đảng bộ Chính phủ, Thủ tướng Phạm Minh Chính yêu cầu xây dựng và thực hiện hiệu quả 5 chiến lược.- Bộ dân tộc và Tôn giáo tổ chức lễ khởi công 3 dự án đầu tư cơ sở vật chất cho các Trường chuyên biệt tại Thái Nguyên, Thanh Hóa và TPHCM.-  Quốc tế đánh giá cao vai trò ngày càng nổi bật của Việt Nam trong chuỗi cung ứng toàn cầu.- Đài TNVN bắt đầu phát sóng loạt bài chính luận: “Trước thềm Đại hội đại biểu toàn quốc lần thứ XIV của Đảng – Lý luận, thực tiễn và kỳ vọng đột phá”, với bài mở đầu nhan đề: “ Xây dựng, chỉnh đốn Đảng trong bối cảnh mới”.- Mỹ tuyên bố dỡ bỏ thêm các lệnh trừng phạt đối với Venezuela ngay trong tuần tới, để tạo điều kiện cho việc bán dầu và chuyển nguồn thu về nước.- Nghị viện châu Âu xem xét khả năng đóng băng Thỏa thuận thương mại quan trọng với Mỹ, do căng thẳng địa chính trị, liên quan tới Grin-len, vùng lãnh thổ tự trị của Đan Mạch.

A tentacle erupts from Doc Miller's foot and crunches down on a mouse. It can only mean one thing - Grin is back.Hunting them in the vents is a Leer - a self-healing, energy-absorbing nightmare. Every attack only makes it stronger. It wraps itself in bandages like a living wound.Clarence astral projects through the chaos just in time for things to get worse. A rhino kaiju smashes into the scene, because reality has officially given up.Then the Leer's bandages begin to peel apart. Two red eyes open inside the wrappings... Watching.The night crew arrives. And that means only one thing:Maintenance.PLAY THE DUST WORLD RPG NOW:We've released the epic RPG Dust world and we want your help. Dust World PBTA is RPG Empire's sci-fi western game that's simple, fast, and Powered By The Apocalypse. Are you ready? Enter The Gun-Filled Lands Of An Obliterated Civilization. Play as gunslinging anime-inspired heroes on their mission to discover the truth behind the lost civilization and its technology.GET THE GUIDE NOW:https://www.therpgempire.com/shop/p/b2ck9ai8u8d7i6j5xs48oojt742uq2Dust world RPG Podcast is an actual play Role-playing podcast like the Adventure Zone Podcast or Critical Role. The setting is a sci-fi western a few hundred years after a great war burned the earth and a virus called white horse dissolved most organic matter into dust creating the wastelands.Dust World RPG is a Powered By The Apocalypse game. Dust World is a Tabletop Role-Playing game created by Paul Parnell Copywrite 2020. The setting was created by Paul Parnell and Michael Yatskar. The game was written by Paul-Thomas Parnell and Dumaresq de Pencier.OTHER PROJECTS FROM THE RPG EMPIRE:Strangers in the Pines: A Monster Of The Week actually play roleplaying podcast inspired by things like Gravity Falls, Stranger Things, and Fringe. It takes place in a small strange town called Pine Forge nestled in the Blackwood national park in Northeast Oregon, USA, and follows, the exploits of 3 unusual high school students as they try to unravel the mysteries of the Strangers in the Pines.

VOV1 - Cộng hòa Síp vừa chính thức tiếp quản vị trí Chủ tịch luân phiên Liên minh châu Âu (EU) kéo dài 6 tháng với hàng loạt thách thức địa chính trị chưa từng có.Nhiệm vụ đầu tiên là tìm kiếm giải pháp cho vấn đề Grin-len của Đan Mạch trước cảnh báo của Tổng thống Mỹ Đô-nan Trăm; bên cạnh các vấn đề nan giải như xung đột Ucraina, đoàn kết nội khối hay khả năng tự chủ chiến lược của khu vực. Với vị trí địa chiến lược ở trung tâm Địa Trung Hải, liệu Cộng hòa Síp sẽ phát huy lợi thế ra sao để thể hiện vai trò và năng lực điều phối khu vực trên cương vị Chủ tịch EU?

In this episode of the 4 Corners Podcast, the guys discuss the Chicago Bears' near miraculous win over the Green Bay Packers. This epic comeback has even Patrick O'Dowd believing that something very special could be brewing for his beloved Bears this season. It is not all rainbows and bliss for the Bears, though, as an ugly stadium dispute with the city of Chicago looms on the horizon. The guys also discuss the first round of the CFP and the ongoing problem with how lower-seeded teams are selected for the tournament.This week's hosts... Patrick O' Dowd (@WrestlngRealist), Rey Cash (@itsreycash) and David Ungar (@AttitudeAgg)For the latest, greatest and up to datest in breaking news, opinions, and podcasts ALWAYS #UseYourHead and visit TheCharishot.com & PROWRESTLINGTEES.COM/THECHAIRSHOTAbout Chairshot Radio NetworkLaunched in 2017, the Chairshot Radio Network presents you with the best in sports, entertainment, and sports entertainment. Wrestling and wrestling crossover podcasts + the most interesting content + the most engaging hosts = the most entertaining podcasts you'll find! MONDAY - Bandwagon Nerds (entertainment & popular culture)TUESDAY - 4 Corners Podcast (sports)WEDNESDAY - The Greg DeMarco Show (wrestling) THURSDAY - POD is WAR FRIDAY - DWI Podcast (Drunk Wrestling Intellect)SATURDAY - The Mindless Wrestling PodcastSUNDAY - The Front and Center Sports Podcast / The Oddity... Keeping the news ridiculous!CHAIRSHOT RADIO NETWORK PODCAST SPECIALSAttitude Of Aggression Podcast & The Big Five Project (chronologically exploring WWE's PPV/PLE history)TheChairshot.com PRESENTS...IMMEDIATE POST WWE PLE REACTIONS w/ DJ(Mindless), Tunney(DWI) & FriendsPatrick O'Dowd's 5X5 Support this podcast at — https://redcircle.com/chairshot-radio-network/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Any donation is greatly appreciated! 47e6GvjL4in5Zy5vVHMb9PQtGXQAcFvWSCQn2fuwDYZoZRk3oFjefr51WBNDGG9EjF1YDavg7pwGDFSAVWC5K42CBcLLv5U OR DONATE HERE: https://www.monerotalk.live/donate TODAY'S SHOW: In this episode of Monero Talk, David Burkett, creator of Litecoin's MimbleWimble Extension Block (MWEB) and developer of Grin++, discusses cryptocurrency privacy technologies with host Douglas Tuman. He shares his journey from early Bitcoin interest to becoming more coin-agnostic due to Bitcoin's scalability and privacy limitations. Burkett explains how MWEB provides basic privacy features, such as hidden transaction amounts and no address reuse, but clarifies that it doesn't offer the same unlinkability as Monero. He also discusses MWEB's extension block structure, adoption challenges, and the future of privacy coins, including potential atomic swaps between MWEB and Monero. TIMESTAMPS: (00:01:21) Show intro & welcoming guest David Burkett (00:02:11) David Burkett background: MimbleWimble, Grin++, Litecoin MWEB (00:06:10) MimbleWimble basics & cryptography accessibility (00:07:11) Motivation: scalable privacy & Bitcoin's transparency problem (00:09:41) Bitcoin pseudonymity, Silk Road era & privacy realities (00:11:30) From Bitcoin maximalism to coin-agnostic tech focus (00:13:08) Exciting privacy developments: full-chain membership proofs (00:16:56) Litecoin MWEB privacy model vs Monero (00:21:04) Network-level surveillance risks explained (00:23:06) Zcash vs Monero vs Litecoin privacy comparisons (00:25:23) Can Litecoin become more private in the future? (00:30:11) Litecoin MWEB usability & real-world marketplace potential (00:34:18) Extension blocks explained (core MWEB architecture) (00:37:48) Future possibilities: atomic swaps, second layers, assets (00:40:11) MWEB adoption stats & transaction volume reality (00:44:44) Importance of merchant & exchange MWEB support (00:47:17) Litecoin's value proposition vs Monero & Zcash (00:51:20) Quantum resistance concerns (or lack thereof) (00:53:08) Where to find David Burkett & closing remarks GUEST LINKS: https://x.com/davidburkett38 Purchase Cafe & tip the farmers w/ XMR! https://gratuitas.org/ SPONSORS: Cakewallet.com, the first open-source Monero wallet for iOS. You can even exchange between XMR, BTC, LTC & more in the app! Monero.com by Cake Wallet - ONLY Monero wallet (https://monero.com/) StealthEX, an instant exchange. Go to (https://stealthex.io) to instantly exchange between Monero and 450 plus assets, w/o having to create an account or register & with no limits. WEBSITE: https://www.monerotopia.com CONTACT: monerotalk@protonmail.com ODYSEE: https://odysee.com/@MoneroTalk:8 TWITTER: https://twitter.com/monerotalk FACEBOOK: https://www.facebook.com/MoneroTalk HOST: https://twitter.com/douglastuman INSTAGRAM: https://www.instagram.com/monerotalk TELEGRAM: https://t.me/monerotopia MATRIX: https://matrix.to/#/%23monerotopia%3Amonero.social MASTODON: @Monerotalk@mastodon.social MONERO.TOWN: https://monero.town/u/monerotalkAny donation is greatly appreciated!Any donation is greatly appreciated!

This week we deep-dive into Whitey's New York filming adventure with Jack Della and team, preview the next round of Tension premieres, share some close-call stories, review Buddah's comedic Canva masterpiece, and and we finish with cricket chaos. Strap in, we back.   TENSION 11 tickets here: https://www.tickettailor.com/events/tensionmovies Tension merch: https://www.tensionmovies.com/shop Surf At Lisbon tickets: https://www.bol.pt/Comprar/Bilhetes/167390-sal_surf_at_lisbon_film_fest_tension_11-cinema_sao_jorge/   For our listeners: Varsity Sports Bar! https://www.varsity.com.au   20% off Rusty TradeR work wear use code: TRADER20GRINREAPERS at www.rusty.com.au/traderworkwear 25% off New Rusty wetsuits  - use code: GRINREAPERS25 at www.rusty.com.au/wetsuits Rusty Locals Only: https://rusty.com.au/collections/locals-only Use code: REAPERS at https://au.manscaped.com/ for 20% discount Support: https://www.patreon.com/ChrisWhitey https://www.patreon.com/BrianShields Other Links:  https://www.instagram.com/chris.whitey https://www.instagram.com/brianshields_ https://www.instagram.com/grin_reapers https://www.facebook.com/GrinReapersMedia/ Web:  www.tensionmovies.com https://itunes.apple.com/au/podcast/the-grin-reapers-podcast/id1380019049

I'm old enough to remember shooting photos with film. In fact, one of the duties I had for my first editing gig at a bowhunting magazine was to scour slides for perfect cover and lead images. Every photo you took back then had to have some intention behind it, because you knew you had limited film, and every shutter click was going to cost you. Today, it's a different story. It's estimated that 2.1 trillion photos will be taken in 2025, and that...

Can your chatbot tell when you're spiraling, or does it just play along?In this episode of Your AI Injection, host Deep Dhillon sits down with Dr. Grin Lord, clinical psychologist and Founder/CEO of mpathic, to explore what happens when empathic AI meets real human vulnerability. Grin explains how a single 15-minute session of empathic listening in an ER setting led to massive drops in repeat drunk-driving incidents and billions in healthcare savings, and why that same science now underpins AI models that analyze clinician–patient conversations. The two dig into how mpathic trains and validates models that can flag suicide risk, psychosis, and protocol deviations in high-stakes clinical trials, all while keeping a human in the loop. They also unpack a looming dilemma: as foundation models become eerily “good listeners,” will people prefer bots to friends and therapists? What harms emerge when AI politely reflects back someone's delusions? Tune in to hear how psychologists are reshaping AI safety, and why your favorite assistant may soon be better at detecting crises than your closest human relationships.Learn more about Grin here: https://www.linkedin.com/in/grinlord/and mpathic here: https://www.mpathic.aiCheck out our related episodes:Can Humanoid Robots Save Us from Loneliness? The Promise and Peril of Empathetic AI with Niv Sundaram of Machani RoboticsIs AI the Missing Ingredient for Curbing Cravings? Emotional Eating Meets Machine Learning with Dr. Sera LavelleCan AI Spot Diseases Your Doctor Might Miss? The Machine That Never Gets Tired with RJ Kedziora of Estenda Solutions

In 1947, a young woman with Hollywood dreams became the center of one of the most infamous unsolved cases in American history. In Part One of this MACABRE Feature, we focus on who Elizabeth Short really was — beyond the headlines, beyond the sensationalism, before she became the legend. We dig into her life, her search for belonging, the world she fell into, and what set the stage for her final days in Los Angeles.This is the story of the woman at the center of the mystery — before the crime scene photos and before the world gave her a name she never asked for. Be sure to follow for next week's shocking conclusion. Spotify subscribers get ad free content, early access and exclusive bonus episodes .Paid supporters on Patreon, Join us for Macabre Movie Nights and Game Nights :⁠⁠⁠⁠ Macabre Patreon⁠⁠⁠⁠Send in your stories for a future listener episode!Email us at thatssomacabre@gmail.comJoin our private Facebook Group at :⁠⁠⁠⁠ MacabrePodcast⁠⁠⁠⁠Get Macabre Exclusive Merch ⁠⁠ www.gothiccthreads.com⁠Sources – The Black DahliaFBI Vault – The Black Dahlia Case Filehttps://vault.fbi.gov/The%20Black%20DahliaGeorge Hodel's District Attorney Files & FBI Surveillance Transcriptshttp://www.stevehodel.com/wp-content/uploads/2016/04/dist-atty-files-hodel-black-dahlia-1.pdfSteve Hodel – Black Dahlia Avenger (Official Site & Blog)https://www.stevehodel.com/Larry Harnisch – The Daily Mirror (Research Blog)https://ladailymirror.com/Los Angeles Times Archives – Black Dahlia Coverage (1947)https://www.latimes.com/archivesNewspapers.com – Black Dahlia Search (Filtered: 1947)https://www.newspapers.com/search/?query=%22black%20dahlia%22&dr_year=1947-1947History.com – “Black Dahlia Murder: The True Story”https://www.history.com/news/black-dahlia-murder-true-storyBiography.com – “Elizabeth Short – The Black Dahlia”https://www.biography.com/crime/elizabeth-shortCrime Museum – “The Black Dahlia Murder”https://www.crimemuseum.org/crime-library/famous-murders/the-black-dahlia-murder/The Sowden House – Official History (George Hodel Residence)https://www.thesowdenhouse.com/history

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We recap the East Coast Tension 11 tour and whats coming up!! TENSION 11 tickets here: https://www.tickettailor.com/events/tensionmovies Tension merch: https://www.tensionmovies.com/shop     For our listeners: Varsity Sports Bar! https://www.varsity.com.au   20% off Rusty TradeR work wear use code: TRADER20GRINREAPERS at www.rusty.com.au/traderworkwear 25% off New Rusty wetsuits  - use code: GRINREAPERS25 at www.rusty.com.au/wetsuits Rusty Locals Only: https://rusty.com.au/collections/locals-only Use code: REAPERS at https://au.manscaped.com/ for 20% discount Support: https://www.patreon.com/ChrisWhitey https://www.patreon.com/BrianShields Other Links:  https://www.instagram.com/chris.whitey https://www.instagram.com/brianshields_ https://www.instagram.com/grin_reapers https://www.facebook.com/GrinReapersMedia/ Web:  www.tensionmovies.com https://itunes.apple.com/au/podcast/the-grin-reapers-podcast/id1380019049

Uncle Si debuts his brand-new smile after finally taking Phil Robertson's advice to get new teeth. Phillip's jaw dropped when Si proudly pulled out the container holding his old teeth on the drive home from the procedure, and Martin relives a disastrous post-dentist hunt that left him regretting every move. John-David fuels everyone's nightmares with his disturbing discovery of teddy bears sewn with human teeth. The boys bow for a powerful moment when Si phones a young fan battling cancer and prays for him, lifting him up to the Almighty. Duck Call Room episode #495 is sponsored by: https://duckstamp.com/duck — Get your all-new digital duck stamp today. It's easier than ever! https://nutrafol.com/duck — Get $10 off your first month's subscription and free shipping! https://www.mypillow.com/duck — Get the MyPillow Bedsheets for just $29.88! Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Grace Yum sits down with Pamela Oren-Artzi, Co-Founder and COO of Grin, to explore how technology is transforming access to dental and orthodontic care. Pamela shares how Grin's digital monitoring platform bridges gaps in affordability, convenience, and provider access—helping dental teams better serve patients and expand their impact. From public health applications to private practice integration, she discusses what it means to “do well by doing good” in today's dental landscape. Episode highlights: Overcoming key barriers in dental access—cost, convenience, awareness, and provider availability How Grin's remote monitoring technology supports equitable, connected oral care Partnering with providers to improve access across public health and community programs Building a mission-driven business that balances growth with social responsibility Ready to thrive as a dentist and a mom? Join a supportive community of like-minded professionals at Mommy Dentists in Business. Whether you're looking to grow your practice, find balance, or connect with others who understand your journey, MDIB is here to help. Visit mommydibs.com to learn more and become a part of this empowering network today!

Arthur Brooks, an economist and former head of the American Enterprise Institute, believes that there is only one remedy for our political polarization: love. In this 2021 episode, we ask if Brooks is a fool for thinking this — and if perhaps you are his kind of fool? SOURCES:Arthur Brooks, professor of public and nonprofit leadership at Harvard University. RESOURCES:“Vital Statistics on Congress,” by Molly Reynolds and Naomi Maehr (Brookings Institute, 2024).Dopamine Nation: Finding Balance in the Age of Indulgence, by Anna Lembke (2021).“Reading Too Much Political News Is Bad for Your Well-Being,” by Arthur Brooks (The Atlantic, 2020).Love Your Enemies: How Decent People Can Save America from the Culture of Contempt, by Arthur Brooks (2019).“This 75-Year Harvard Study Found the 1 Secret to Leading a Fulfilling Life,” by Melanie Curtin (Inc., 2017).The Conservative Heart: How to Build a Fairer, Happier, and More Prosperous America, by Arthur Brooks (2015).“Grin and Bear It: The Influence of Manipulated Facial Expression on the Stress Response,” by Tara Kraft and Sarah Pressman (Psychological Science, 2012). EXTRAS:“Why Is U.S. Media So Negative?” by Freakonomics Radio (2021). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, I'm joined by the always insightful and globally-minded Dr. Vas Srinivasan, who recently built one of the most stunning orthodontic spaces in Southeast Queensland—right when the world said “don't.” From battling banks post-COVID to doubling down on patient experience, Vas shares the inspiring story of why he took the leap, what he learned, and how he's now positioned to dominate his local market—even against corporate competitors.We talk about fear, growth, AI-powered offices, why silent front desks are the future, and how to turn brushing stations into monitoring hubs. We also get into real estate side hustles, building partnerships outside of dentistry, and the importance of having income streams that work while you sleep. This is a must-listen for any orthodontist who's wondering if now is the time to play biggerQUOTES“If someone says they weren't scared building a practice like this—they're lying. I had to re-mortgage my house. But this dream had to come together.”— Dr. Vas Srinivasan“Side hustles are great. But please—don't do a restaurant. Don't do a nightclub. Find something that works even when you're asleep.”— Dr. Vas SrinivasanKey TakeawaysIntro (00:00)Vegemite vs. Tim Tams and Aussie hospitality (01:26)Vas's global journey: India → Minnesota → Sydney → Sunshine Coast (04:19)Why he rebuilt his practice at 48—and made it huge (08:27)Fear, funding struggles, and re-mortgaging his house (09:50)Building for the wow: concierge front desks & AI systems (14:06)Turning brushing stations into Grin monitoring hubs (15:45)A shift away from aligners—and why patients are saying no (17:09)Don't confuse patients: how to present treatment options better (19:27)Real estate side hustle with his ex-TC as a partner (21:35)The “low-cost braces clinic” model that fuels his main practice (23:15)Why now is the time to invest in yourself and your future (25:47)The Vanguard announcement + what's next (26:59)Additional ResourcesIf you've been waiting for the “perfect time” to level up your space, your systems, or your side hustle—this episode is your permission slip. Fear and growth go hand in hand, but so does freedom when you build it intentionally.

Send us a textLou Vickery—former New York Yankees pitcher, five-time career changer, and author of 26 books—is the living embodiment of Active Engagement and the Voice of Generational Wisdom. In this inspiring interview, Lou shares the incredible wisdom he gained over 67 years in the workplace , from the pitcher's mound to Merrill Lynch in New York.Lou reveals the secrets to his Longevity and Purpose, including the powerful story of how his commitment to fitness literally saved his life during a 22-day battle with COVID-19. His life is a blueprint for finding meaning and staying vital at any age. Learn why Lou believes there are "only two kinds of days in my life: good and better"  and how you can apply his timeless advice to live a healthier, more fulfilled life!

What happens if you get to the third date and it still feels awkward? Grin and bear it? Or keep waiting for chemistry? And how can you trust that your gut is telling you the right thing? This week, a listener shares: "I met a man who checks every box on paper. He's kind, reliable, matches my values… but I feel absolutely nothing. No spark. No butterflies. Is something wrong with me?" In this episode, Damona shares the truth about emotional resonance, why the three-date rule isn't a trap, and how to tell the difference between being too picky and being truly honest with yourself.  You'll hear how to identify the signals your body sends you, why humor matters more than you think, and why being “decent” should never be the bar. What You'll Hear In This Episode: What the three-date rule really means (and what it doesn't) Why “good on paper” doesn't always translate to connection How to tell if you're genuinely curious or just people-pleasing The surprising role of humor in long-term compatibility How to do an energy check after every date What your nervous system is trying to tell you The difference between settling and staying open Connect With Us: Get your copy of "F the Fairy Tale: Rewrite the Dating Myths and Live Your Own Love Story" Unlock the Secret to Successful Dating with our ⁠⁠Date Tracker⁠⁠ Call or text your question to: 424-246-6255 Follow @damonahoffman on ⁠⁠Instagram⁠⁠, ⁠⁠TikTok⁠⁠, and ⁠⁠Facebook⁠⁠, and submit questions via DM or voice memo anytime. Learn more about your ad choices. Visit megaphone.fm/adchoices

Ben Maller talks about Ben Johnson having a meltdown over the Bears' effort against the Lions, Patrick Mahomes spinning the Chiefs 0-2 start as an "opportunity," Vikings backup QB Carson Wentz drawing rave reviews, Lame Jokes of the Week, and more!See omnystudio.com/listener for privacy information.

On this episode the guys discuss Having children, Getting a vasectomy, Reggae Artists with the most children, Sexual encounters overseas, Rub & Tugs, Cruises, Plus tells a story about his dad, Chris wins big on a parlay, women you know having an Only Fans during the pandemic, Pick up lines and more SOTW: Project Pat x Take Da Charge

Blooming heck the Premier League is back! Today, Marcus and Luke kick off our weekend preview by encouraging Pete to apply for the job of Manchester United DJ to try to improve the atmosphere at Old Trafford. With Alpacafest on his CV surely they can't refuse.Speaking of which, the Ferryman is now driving a party boat as the vibes are flying high at Everton after Jack Grealish's 30th birthday this week. Plus, Luke gives us his thoughts ahead of the "second biggest game of the weekend": Southampton vs Portsmouth.Please fill out Stak's listener survey! It'll help us learn more about the content you love so we can bring you even more - you'll also be entered into a competition to win one of five PlayStation 5's! Click here: https://bit.ly/staksurvey2025Sign up to the Football Ramble Patreon for ad-free shows for just $5 per month: https://www.patreon.com/footballramble.Find us on Bluesky, X, Instagram, TikTok, WhatsApp and YouTube, and email us here: show@footballramble.com.***Please take the time to rate us on your podcast app. It means a great deal to the show and will make it easier for other potential listeners to find us. Thanks!*** Hosted on Acast. See acast.com/privacy for more information.

A man carries out what he believes is a flawlessly executed killing. But soon after, he begins to unravel—plagued by guilt, paranoia, or fate — learning too late that no crime goes unpunished. Death, it seems, has the final laugh. Hear the story from The Sealed Book! | #RetroRadio EP0436Join the DARKNESS SYNDICATE: https://weirddarkness.com/syndicateCHAPTERS & TIME STAMPS (All Times Approximate)…00:00:00.000 = Show Open00:01:50.000 = CBS Radio Mystery Theater, “The Love Song of Death” (April 21, 1976)00:47:05.229 = Mystery Playhouse from Molle, “Female of the Species” (June 07, 1946) ***WD01:12:24.779 = The Price of Fear, “Guy Fawkes Night” (November 17, 1973)01:40:24.759 = Adventures of Ellery Queen, “Nikki Porter, Suspect” (March 05, 1947) ***WD02:06:15.549 = Quiet Please, “Gem of the Purest Ray” (May 17, 1948)02:35:55.909 = Radio City Playhouse, “Wisdom of Eve” (January 24, 1949)03:05:58.479 = Isn't It Crime, “Speaking of Murder” (December 14, 1945)03:35:08.139 = Ripley's Believe It Or Not, “Never Bitten” (1930s) ***WD03:36:10.331 = The Saint, “Wanted: A Husband” (October 29, 1950)04:02:12.209 = Sam Spade, “Apple of Eve Caper” (June 19, 1949) ***WD04:30:37.629 = The Sealed Book, “Death Laughs Last” (September 02, 1945)05:00:12.229 = Show Close(ADU) = Air Date Unknown(LQ) = Low Quality***WD = Remastered, edited, or cleaned up by Weird Darkness to make the episode more listenable. Audio may not be pristine, but it will be better than the original file which may have been unusable or more difficult to hear without editing.Weird Darkness theme by Alibi Music LibraryABOUT WEIRD DARKNESS: Weird Darkness is a true crime and paranormal podcast narrated by professional award-winning voice actor, Darren Marlar. Seven days per week, Weird Darkness focuses on all thing strange and macabre such as haunted locations, unsolved mysteries, true ghost stories, supernatural manifestations, urban legends, unsolved or cold case murders, conspiracy theories, and more. On Thursdays, this scary stories podcast features horror fiction along with the occasional creepypasta. Weird Darkness has been named one of the “Best 20 Storytellers in Podcasting” by Podcast Business Journal. Listeners have described the show as a cross between “Coast to Coast” with Art Bell, “The Twilight Zone” with Rod Serling, “Unsolved Mysteries” with Robert Stack, and “In Search Of” with Leonard Nimoy.= = = = ="I have come into the world as a light, so that no one who believes in me should stay in darkness." — John 12:46= = = = =WeirdDarkness® is a registered trademark. Copyright ©2025, Weird Darkness.= = = = =CUSTOM WEBPAGE: https://weirddarkness.com/WDRR0436