POPULARITY
In der heutigen Folge des Experten-Podcasts spricht Andreas Gratzl, leidenschaftlicher Chiropraktiker und Osteopath für Erwachsene, Kinder und Säuglinge, darüber, wie die innere Einstellung betroffener Personen zum Erfolg der Heilung beitragen kann. Du erfährst auch, welches bedeutende Lebensereignis die Entwicklung des Therapeuten selbst beeinflusst hat.Außerdem verrät Andreas Gratzl seine besten Strategien, um in einem harmonischen Miteinander zwischen Therapeut und Patient das bestmögliche Behandlungsergebnis zu erzielen.Wenn auch Du wissen willst, wie Du aktiv bei deiner Heilung mitwirken kannst, dann solltest Du diese Folge des Experten-Podcasts nicht verpassen.Hat Dir der Experte des Tages gefallen, hast Du etwas für Dich mitnehmen können?Weitere Informationen bekommst Du unter https://heilpraktiker-gratzl.de/ . See acast.com/privacy for privacy and opt-out information.
How good are we at predicting outcome in severe TBI? Do all patients do bad, or are there some that recover? On this episode Karl dives into the data to give us an update on what the data supports. Literature Referenced: What early predictions do we make? Barlow, P., Teasdale, G. (1986). Prediction of Outcome and the Management of Severe Head Injuries: The Attitudes of Neurosurgeons Neurosurgery 19(6), 989-991. https://dx.doi.org/10.1227/00006123-198612000-00014 How good are we at predicting outcomes in ICU patients? Kaufmann, M., Buchmann, B., Scheidegger, D., Gratzl, O., Radü, E. (1992). Severe head injury: should expected outcome influence resuscitation and first-day decisions? Resuscitation 23(3), 199-206. https://dx.doi.org/10.1016/0300-9572(92)90003-u Brain Trauma Foundation guidelines on prognosis in severe TBI https://www.braintrauma.org/guidelines/prognosis IMPACT calculator to model TBI outcome http://www.tbi-impact.org/ Updated practice guidelines on the management of patients with disorders of consciousness Giacino, J., Katz, D., Schiff, N., Whyte, J., Ashman, E., Ashwal, S., Barbano, R., Hammond, F., Laureys, S., Ling, G., Nakase-Richardson, R., Seel, R., Yablon, S., Getchius, T., Gronseth, G., Armstrong, M. (2018). Practice guideline update recommendations summary: Disorders of consciousness: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability, Independent Living, and Rehabilitation Research Neurology 91(10), 10.1212/WNL.0000000000005926. https://dx.doi.org/10.1212/wnl.0000000000005926
Sat, 1 Jan 1994 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7371/1/Gratzl_Manfred_7371.pdf Gratzl, Manfred; Sinowatz, F.; Amselgruber, W.; Totzauer, I.
Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7512/1/7512.pdf Gratzl, Manfred; Lahr, G. ddc:610, Medi
Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7369/1/7369.pdf Gratzl, Otmar; Gratzl, Manfred; Vereczkey, Csaba; Zhang, Tiang-Ming; Mendelowitsch, Aminadav
Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7358/1/7358.pdf Gratzl, Manfred; Warchol, W.; Föhr, K. J.
Fri, 1 Jan 1993 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7357/1/7357.pdf Gratzl, Manfred; Beyer, C.; Stecher, B.; Ahnert-Hilger, G. ddc:610, Medizin
Wed, 1 Jan 1992 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7360/1/Gratzl_Manfred_7360.pdf Gratzl, Manfred; Gratzl, O.; Vereczkey, C.; Langley, K.; Lahr, G.
We have previously described a 30 kDa basic fibroblast growth factor (bFGF)-like protein in rodent testicular homogenates and have shown that pachytene spermatocytes are the sites of predominant immunoreactivity for this bFGF-like protein (Mayerhofer, A., Russell, L.D., Grothe, C., Rudolf, M. and Gratzl, M. (1991) Endocrinology 129, 921–924). We have now addressed the question whether this 30 kDa bFGF-like protein is a large bFGF form and whether it is produced by pachytene spermatocytes. We detected bFGF mRNA in homogenates of isolated mouse spermatocytes (which consisted mainly of pachytene spermatocytes) using S1 nuclease protection assays. As shown by Western blot analyses, the bFGF mRNA in mouse spermatocytes is translated into bFGF of an approximate molecular weight of 30 kDa. Neither bFGF mRNA, nor bFGF itself, was observed in isolated mouse Leydig cells. These results indicate that the immunoreactive bFGF-like protein observed previously in germ cells of the murine testis is identical to bFGF. Thus, germ cells of the testis produce bFGF, which may exert regulatory function in the process of spermatogenesis.
Tue, 1 Jan 1991 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7589/1/7589.pdf Gratzl, Manfred ddc:610, Medizin 0
Tue, 1 Jan 1991 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7511/1/7511.pdf Gratzl, Manfred; Langley, K. ddc:610, Medizin
Tue, 1 Jan 1991 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7208/1/7208.pdf Langley, K.; Gratzl, Manfred ddc:610, Medizin
Mon, 1 Jan 1990 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7509/1/7509.pdf Gratzl, Manfred; Ehrhart, M. ddc
Mon, 1 Jan 1990 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7508/1/7508.pdf Gratzl, Manfred; Langley, O. K.; Aletsee-Ufrecht, M. C. ddc:610, Medizin
Sun, 1 Jan 1989 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7237/1/7237.pdf Gratzl, Manfred; Föhr, Karl Josef; Mach, Wolfgang; Ahnert-Hilger, Gudrun ddc:610, Medizin
Fri, 1 Jan 1988 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7504/1/7504.pdf Gratzl, Manfred ddc:610, Medizin
Fri, 1 Jan 1988 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7501/1/7501.pdf Gratzl, Manfred ddc:610, Medizin
Fri, 1 Jan 1988 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7505/1/7505.pdf Gratzl, Manfred; Ahnert-Hilger, G.; Langley, O. K.; Aletsee-Ufrecht, M. C. ddc:610, Medizin
Fri, 1 Jan 1988 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7377/1/Gratzl_Manfred_7377.pdf Gratzl, Manfred; Ahnert-Hilger, G. ddc:610, Medizi
Thu, 1 Jan 1987 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7496/1/7496.pdf Gratzl, Manfred ddc:610, Medizin
Thu, 1 Jan 1987 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7500/1/7500.pdf Gratzl, Manfred ddc:61
Recently we found that Ca2+ within chromaffin vesicles is largely bound [Bulenda, D., & Gratzl, M. (1985) Biochemistry 24, 7760-77651. In order to explore the nature of these bonds, we analyzed the binding of Ca2+ to the vesicle matrix proteins as well as to ATP, the main nucleotide present in these vesicles. The dissociation constant at pH 7 is 50 pM (number of binding sites, n = 180 nmol/mg of protein) for Ca2+-protein bonds and 15 pM (n = 0.8 pmol/pmoi) for Ca2+-ATP bonds. When the pH is decreased to more physiological values (pH 6), the number of binding sites remains the same. However, the affinity of Ca2+ for the proteins decreases much less than its affinity for ATP (dissociation constant of 90 vs. 70 pM). At pH 6 monovalent cations (30-50 mM) as well as Mg2+ (0.1-0.5 mM), which are also present within chromaffin vesicles, do not affect the number of binding sites for Ca2+ but cause a decrease in the affinity of Ca2+ for both proteins and ATP. For Ca2+ binding to ATP in the presence of 0.5 mM Mg2+ we found a dissociation constant of 340 pM and after addition of 35 mM K+ a dissociation constant of 170 pM. Ca2+ binding to the chromaffin vesicle matrix proteins in the presence of 0.5 mM Mg2+ is characterized by a Kd of 240 pM and after addition of 15 mM Na' by a Kd of 340 pM. The similar affinity of Ca2+ for protein and ATP, especially at pH 6, in media of increased ionic strength and after addition of Mg2+, points to the possibility that the intravesicular medium determines whether Ca2+ is preferentially bound to ATP or the chromaffin vesicle matrix proteins. Purified chromogranin A, after sodium dodecyl sulfate- polyacrylamide gel electrophoresis, stains with a carbocyanine dye ("Stains-all") and, following blotting onto nitrocellulose, binds to 45Ca2+. A spectrophotometric analysis of dye binding to chromaffin vesicle matrix proteins revealed a strong absorption band at 615 nm for the dye-protein complex. Since the observed spectral changes were unaffected by the presence of Ca2+ (100 pM free), the sites interacting with the dye and Ca2+ must be regarded as different.
Wed, 1 Jan 1986 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7138/1/Gratzl_Manfred_7138.pdf Gratzl, Manfred; Reiffen, F. U. ddc:610, Medizin
Sat, 1 Jan 1983 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7202/1/7202.pdf Thorn, N. A.; Russell, J. T.; Gratzl, Manfred
Thu, 1 Jan 1981 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7199/1/7199.pdf Krieger-Brauer, H.; Gratzl, Manfred
Tue, 1 Jan 1980 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7498/1/7498.pdf Dahl, G.; Ekerdt, R.; Gratzl, Manfred ddc:610, Medizin
Tue, 1 Jan 1980 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7495/1/7495.pdf Gratzl, Manfred ddc:610, Medizin
Tue, 1 Jan 1980 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7492/1/7492.pdf Dahl, Gerhard; Schudt, Christian; Ekerdt, Roland; Gratzl, Manfred ddc:610, Medizin
Tue, 1 Jan 1980 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7131/1/7131.pdf Thorn, N. A.; Treiman, M.; Dartt, D.; Torp-Pedersen, C.; Gratzl, Manfred ddc:610,
Mon, 1 Jan 1979 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7373/1/7373.pdf Gratzl, Manfred; Ekerdt, Roland; Dahl, Gerhard ddc:610, Medizin
Sat, 1 Jan 1977 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7584/1/7584.pdf Gratzl, Manfred; Dahl, G.; Russell, J. T.; Thorn, N. A. ddc:610, Medizin
Sat, 1 Jan 1977 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7192/1/7192.pdf Thorn, N. A.; Russell, J. T.; Dahl, G.; Gratzl, Manfred ddc:610, Medizin
Thu, 1 Jan 1976 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7133/1/7133.pdf Gratzl, Manfred; Dahl, G. dd
Thu, 1 Jan 1976 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7196/1/Gratzl_Manfred_7196.pdf Gratzl, Manfred; Ruf, H. H. ddc:610, Medizin
Thu, 1 Jan 1976 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7135/1/7135.pdf Gratzl, Manfred; Dahl, G.; Schudt, C. d
Thu, 1 Jan 1976 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7134/1/7134.pdf Schwab, D.; Gratzl, Manfred
Wed, 1 Jan 1975 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7154/1/7154.pdf Scheurlen, P.; Seebach, H. B. von; Pess, H.; Gratzl, Manfred; Girmann, G.
Wed, 1 Jan 1975 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7132/1/7132.pdf Schwab, D.; Nastainczyk, W.; Gratzl, Manfred ddc:610, Medizin
Wed, 1 Jan 1975 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7130/1/7130.pdf Gratzl, Manfred ddc:610, Medizin
Tue, 1 Jan 1974 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7193/1/Gratzl_Manfred_7193.pdf Ullrich, V.; Gratzl, Manfred; Deutschmann, G. ddc:610, Medizin
Mon, 1 Jan 1973 12:00:00 +0100 https://epub.ub.uni-muenchen.de/7129/1/7129.pdf Remmer, Herbert; Gratzl, Manfred; Betz, Heinrich ddc:610, Medizin