Podcasts about results analysis

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Best podcasts about results analysis

Latest podcast episodes about results analysis

Scholars & Sense
VA & NJ Governor Election Results Analysis | EP 11

Scholars & Sense

Play Episode Listen Later Nov 5, 2021 41:24


Bill, Conrad & Victor discuss the results of the VA & NJ Governor races. What does this mean for the Republicans? Will the Democrats learn that their policies aren't working? What does this mean for Trump?

The Clement Manyathela Show
Results Analysis

The Clement Manyathela Show

Play Episode Listen Later Nov 2, 2021 7:43


Clement Manyathela is joined by the Director of Third Republic, Paul Berkowitz to analyse the election results. See omnystudio.com/listener for privacy information.

Yadnya Investment Academy
Tech Mahindra Q2 FY22 Results Analysis

Yadnya Investment Academy

Play Episode Listen Later Oct 27, 2021 8:44


Tech Mahindra shares soared to a record high today to Rs.1,629 post Sept-21 quarter earnings. Q2 FY22 was a strong quarter for the company on all parameters - growth, margins, deal TCV. Here is a detailed 6 point analysis of Tech Mahindra Q2 FY22 Results.

Body Mind Empowerment with Siim Land
#271 My Bloodwork Results Analysis on Inside Tracker - Fear Michelle Darian, MS

Body Mind Empowerment with Siim Land

Play Episode Listen Later Oct 22, 2021 45:33


Welcome to the Siim Land podcast I'm your host Siim Land and our guest today is Michelle Darian. Michelle is a nutrition scientist and a registered dietitian in Inside Tracker. In this episode, Michelle and I are going to take a look at my recent bloodwork on the Inside Tracker platform. Inside Tracker is an at-home biomarker service that you can use to test up to 43 different biomarkers like lipids, liver enzymes, inflammation, sex hormones, and much more. The process is simple – you order the test kit to your home, use the little finger prick device to give your blood, send it back, and you get results to your online dashboard or app. You can get a 25% discount code off all their tests if you head over to siimland.com/insidetracker that's in one word and use the code SIIMLAND at checkout. That's siimland.com/insidetracker and the code is SIIMLAND. Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon This episode is sponsored by BiOptimizers. They're giving the listeners of this podcast an exclusive offer on one of their best-selling products. It's called Magnesium Breakthrough and is the most full-spectrum magnesium supplement out there. Most supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. Magnesium is the master mineral that governs virtually all physiological processes in the body.  With volume discounts combined with our custom 10% coupon code, SIIM10, you can save up to 40% off select packages of Magnesium Breakthrough! That's an AMAZING value. And I promise that deal is ONLY available on this specific website,  Click Here to Support the Show on Patreon!   Show Notes Join Inside Tracker for 25% Off with Code SIIMLAND Lucas Aoun's Natural Testosterone Optimization Course 10% OFF The Immunity Fix on Amazon Get Magnesium Breakthrough for a 10% Discount! Use Code SIIM for 10% Off Self Decode Use Code SIIM for a 10% Discount on the KAATSU Bands My New Book Stronger by Stress My NEW BOOK Metabolic Autophagy Metabolic Autophagy Audiobook Metabolic Autophagy Master Class Total Sleep Optimization Video Course Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program Stay Empowered Siim          

Yadnya Investment Academy
Coromandel International Q1 FY22 Results Analysis

Yadnya Investment Academy

Play Episode Listen Later Jul 30, 2021 5:30


Yadnya Investment Academy
Dr. Reddy's Q1FY22 Results Analysis | Why stock hit lower circuit?

Yadnya Investment Academy

Play Episode Listen Later Jul 30, 2021 6:41


Dr. Reddy's, India's biggest pharma company hit the lower circuit on 27th July, what happened? 

The Gary Null Show
The Gary Null Show - 06.21.21

The Gary Null Show

Play Episode Listen Later Jun 21, 2021 53:31


VIDEOS   1. Sen. Johnson and Dr. Pierre Kory on the impact of censorship in fight against COVID-19   2. New Rule: Getting It in the Nuts | Real Time with Bill Maher (HBO)   3.  Black father destroys critical race theory at school board meeting   4.  Wuhan 15,00 bat samples and their virus databases all wiped from the internet   5. Fauci, Gain-of-Function Research, and Wuhan Lab Funding. Joe Rogan with Krystal Ball & Saagar Enjeti   Krystal Ball and Sagaar Enjeti are political commentators and hosts of the YouTube show and podcast "Breaking Points".   CoQ10 supplementation associated with lower pro-inflammatory factors in randomized trial Shahid Sadoughi University of Medical Sciences (Iran), June 8 2021    A double-blind trial reported in the International Journal of Vitamin and Nutrition Research found a reduction in markers ofinflammation in mildly hypertensive patients given coenzyme Q10 (CoQ10) for twelve weeks. Participants who received CoQ10 also experienced an increase in adiponectin: a protein secreted by adipose tissue that has an anti-inflammatory effect and which has been found to be reduced in high blood pressure and cardiovascular disease.   "Considering that coenzyme Q10 has attracted noticeable attention in recent years for the treatment of cardiovascular diseases and hypertension in regard to its effect on inflammatory factors such as cytokines, it is therefore hypothesized that supplementation with coenzyme Q10 reduces the proinflammatory factors," write Nasim Bagheri Nesami of Iran's Shahid Sadoughi University of Medical Sciences and colleagues. "This study was conducted in order to determine the effects of coenzyme Q10 on proinflammatory factors as well as on adiponectin in patients with mild hypertension." Sixty men and women were randomized to receive 100 milligrams CoQ10 or a placebo for a twelve week period. Plasma adiponectin, high-sensitivity C-reactive protein (hs-CRP, a marker of inflammation) and the cytokines interleukin 2, interleukin 6 and tumor necrosis factor-alpha were measured before and after treatment. At the end of the study, participants who received CoQ10 had significant declines in interleukin-6 and hs-CRP compared with levels measured upon enrollment. They also experienced an increase in adiponectin, while levels in the placebo group slightly declined. The authors suggest that CoQ10 could be prescribed as a supplement along with antihypertensive medication for patients with mildly elevated blood pressure, and recommend that further research be conducted to validate the current findings.     Exposure to nature during COVID-19 lockdown was beneficial for mental health A study by the ICTA-UAB and the University of Porto analyses the effects of exposure to green spaces during the first months of the COVID19 pandemic in Spain and Portugal Universitat Autònoma of Barcelona (Spain), June 18, 2021 A study carried out by the Institute of Environmental Science and Technology of the Universitat Autònoma de Barcelona (ICTA-UAB) and the Instituto de Saúde Pública of the University of Porto (ISPUP), concludes that exposure to natural spaces during the first COVID-19 lockdown in 2020 was beneficial for the mental health of Spanish and Portuguese citizens. The research shows that, in Portugal, during the first confinement, people who maintained or increased contact with natural public spaces, such as parks and coastal areas, or who could contemplate these spaces from their homes, presented lower levels of stress, psychological distress and psychosomatic symptoms. In Spain, those who maintained or increased contact with private natural spaces, such as indoor plants or community green areas, presented lower levels of stress and psychosomatic symptoms. This could be due to the fact that Spain adopted more restrictive measures for foreign circulation during the period analysed. The research Exposure to nature and mental health outcomes during COVID-19 lockdown. A comparison between Portugal and Spain, published in the journal Environment International, was conducted between March and May 2020. Dr Ana Isabel Ribeiro, researcher at the ISPUP and first author of the work together with Margarita Triguero-Mas from the ICTA-UAB says that "we decided to study whether natural, public and private spaces had a beneficial effect on the mental health of Portuguese and Spanish citizens, helping them to better cope with the negative effects of lockdown". For her part, Margarita Triguero-Mas adds that "people around us and ourselves talked about how we missed the park we crossed when we went to the office or the walk on the beach with our dogs, so we wanted to check to what extent contact with natural spaces was an important factor during confinement". Several previous articles have also shown the positive impact of exposure to natural spaces on mental health, that is, in reducing stress, anxiety and improving psychological well-being as a whole. "Taking into account what is described in the literature, we wanted to evaluate whether people who enjoyed greater exposure to natural spaces during the first COVID-19 lockdown had better mental health indicators than those who had no contact with natural areas", explains Dr Ribeiro. At the same time, they wanted to investigate whether exposure to private natural spaces, such as gardens, orchards or plants, was more beneficial among Spanish citizens than among Portuguese, given that Spain applied stricter measures to restrict mobility than Portugal. To carry out the research, the authors applied an online questionnaire, between March 27 and May 6, 2020, aimed at all citizens aged 18 years old or older, residing in Spain or Portugal. The survey covered aspects related to the frequency and type of exposure people had to natural spaces (public and private), before and during the first confinement; mental health questions to assess levels of stress, mental disorders and somatization symptoms, and sociodemographic issues. Of the more than 3,000 citizens (n = 3,157) who answered the questionnaire, 1,638 were Portuguese and 1,519 Spanish. In both countries, during the confinement, there was a significant reduction in the use of public natural spaces, such as beaches, parks and gardens, and an increase in contact with private natural spaces, such as community gardens, urban gardens and plants, especially in Spain. People living in single-family houses (detached house) and flats located in cities were the ones who least maintained or increased their exposure to public natural spaces in both countries. In Spain, where the measures during the period analysed were much more restrictive and it was forbidden to leave the house and public outdoor spaces were closed, the benefits of exposure to public natural spaces were not as relevant as in Portugal, but it was clear the importance of private natural elements. Among the Spanish citizens who participated in the study, 66% decreased the frequency of exposure to public natural spaces (compared to 54% in Portugal). In Spain, people who had the opportunity to continue dedicating or increasing the time dedicated to caring for their plants had lower stress levels, while those who were able to continue enjoying or increasing the time of use of community green spaces had lower rates of somatization.  In Spain, it is remarkable that the people who least maintained or increased the care of indoor plants were people over 65 years of age, those who lived with several people at home or those who were in a second residence during confinement. In contrast, the people who maintained or increased the care of indoor plants the most were those with children, but without dependent adults. In Portugal, those who were confined the longest and those who commuted to work were those who least maintained or increased their contact with the natural public spaces. In turn, those who practiced physical exercise indicated greater exposure to these places. Portuguese citizens who managed to maintain or increase their exposure to natural public spaces showed lower levels of stress compared to those who did not. Likewise, those who contemplated natural spaces from their homes obtained improvements in all the mental health outcomes analysed: stress, mental disorders and somatization. "This study clearly demonstrates the benefit of natural spaces for the mental health of the population in a context of public health crisis," says Ana Isabel Ribeiro. "Public authorities and decision-makers could implement measures that facilitate access to natural public spaces, in a safe and controlled manner, in the context of a pandemic. This is particularly important for the most socially and economically vulnerable population groups, and for those who have little access to these spaces in their private context", she emphasizes. In addition, Dr Triguero-Mas adds that "our study is especially important for cities like Barcelona, where new buildings rarely have balconies or community spaces with vegetation. It is important to revalue how building remodelling or new homes can be healthier spaces that promote and prevent deterioration in the health of the people who inhabit them". Flame retardants and pesticides overtake heavy metals as biggest contributors to IQ loss New York University, June 2, 2021   Adverse outcomes from childhood exposures to lead and mercury are on the decline in the United States, likely due to decades of restrictions on the use of heavy metals, a new study finds. Despite decreasing levels, exposure to these and other toxic chemicals, especially flame retardants and pesticides, still resulted in more than a million cases of intellectual disability in the United States between 2001 and 2016. Furthermore, as the target of significantly fewer restrictions, experts say, flame retardants and pesticides now represent the bulk of that cognitive loss. NYU Grossman School of Medicine researchers found that IQ loss from the toxic chemicals analyzed in their study dropped from 27 million IQ points in 2001 and 2002 to 9 million IQ points in 2015 and 2016. While this overall decline is promising, the researchers say, their findings also identify a concerning shift in which chemicals represent the greatest risk. Among toxin-exposed children, the researchers found that the proportion of cognitive loss that results from exposure to chemicals used in flame retardants, called polybrominated diphenyl ethers (PDBEs), and organophosphate pesticides increased from 67 percent to 81 percent during the same study period. "Our findings suggest that our efforts to reduce exposure to heavy metals are paying off, but that toxic exposures in general continue to represent a formidable risk to Americans' physical, mental, and economic health," says lead study investigator Abigail Gaylord, MPH, a doctoral candidate in the Department of Population Health at NYU Langone. "Unfortunately, the minimal policies in place to eliminate pesticides and flame retardants are clearly not enough." The substances analyzed are found in household products from furniture upholstery to tuna fish, and can build up in the body to damage organs, researchers say. Heavy metals, lead and mercury in particular, are known to disrupt brain and kidney function. In addition, they, along with flame retardants and pesticides, can interfere with the thyroid, which secretes brain-developing hormones. Experts say exposure at a young age to any of these toxins can cause learning disabilities, autism, and behavioral issues. In their investigation, the researchers found that everyday contact with these substances during the 16-year study period resulted in roughly 1,190,230 children affected with some form of intellectual disability. Overall childhood exposures cost the nation $7.5 trillion in lost economic productivity and other societal costs. "Although people argue against costly regulations, unrestricted use of these chemicals is far more expensive in the long run, with American children bearing the largest burden," says senior study author Leonardo Trasande, MD, MPP, the Jim G. Hendrick, MD Professor at NYU Langone Health. Publishing online Jan. 14 in the journal Molecular and Cellular Endocrinology, the new study is the only long-term neurological and economic investigation of its kind, the authors say. The investigators analyzed PBDE, organophosphate, lead, and methylmercury exposures in blood samples from women of childbearing age and 5-year-olds. Data on women and children was obtained from the National Health and Nutrition Examination Survey. The researchers used results from several previous environmental health studies to estimate the annual number of IQ points lost per unit of exposure to each of the four main chemicals in the study. Then, they estimated the lost productivity and medical costs over the course of the children's lives linked to long-term intellectual disability using a second algorithm, which valued each lost IQ point at $22,268 and each case of intellectual disability at $1,272,470. While exposure to these chemicals persists despite tightened regulations, experts say Americans can help limit some of the effects by avoiding the use of household products or foods that contain them. "Frequently opening windows to let persistent chemicals found in furniture, electronics, and carpeting escape, and eating certified organic produce can reduce exposure to these toxins," says Trasande, who also serves as chief of environmental pediatrics in the Department of Pediatrics at NYU Langone. Trasande notes that the impact of these chemicals may be worse than their study can capture since there are far more hazards that affect brain development than the four highlighted in the investigation, and other potential consequences beyond IQ loss. "All the more reason we need closer federal monitoring of these substances," she says. The study authors say they plan to explore the cost of exposure to endocrine-disrupting chemicals in other countries. Red meat consumption may promote DNA damage-assoc. mutation in colorectal cancer patients Study provides mechanistic link between red meat consumption and colorectal cancer development Harvard Medical School, June 17, 2021 Bottom Line: Genetic mutations indicative of DNA damage were associated with high red meat consumption and increased cancer-related mortality in patients with colorectal cancer. Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research Author: Marios Giannakis, MD, PhD, an assistant professor of medicine at Harvard Medical School and a physician at Dana-Farber Cancer Institute Background: "We have known for some time that consumption of processed meat and red meat is a risk factor for colorectal cancer," said Giannakis. The International Agency for Research on Cancer declared that processed meat was carcinogenic and that red meat was probably carcinogenic to humans in 2015.  Experiments in preclinical models have suggested that red meat consumption may promote the formation of carcinogenic compounds in the colon, but a direct molecular link to colorectal cancer development in patients has not been shown, Giannakis explained. "What is missing is a demonstration that colorectal cancers from patients have a specific pattern of mutations that can be attributed to red meat," he said. "Identifying these molecular changes in colon cells that can cause cancer would not only support the role of red meat in colorectal cancer development but would also provide novel avenues for cancer prevention and treatment." How the Study was Conducted: To identify genetic changes associated with red meat intake, Giannakis and colleagues sequenced DNA from matched normal and colorectal tumor tissues from 900 patients with colorectal cancer who had participated in one of three nationwide prospective cohort studies, namely the Nurses' Health Studies and the Health Professionals Follow-Up Study. All patients had previously provided information on their diets, lifestyles, and other factors over the course of several years prior to their colorectal cancer diagnoses.  Results: Analysis of DNA sequencing data revealed the presence of several mutational signatures in normal and cancerous colon tissue, including a signature indicative of alkylation, a form of DNA damage. The alkylating signature was significantly associated with pre-diagnosis intake of processed or unprocessed red meat, but not with pre-diagnosis intake of poultry or fish or with other lifestyle factors. Red meat consumption was not associated with any of the other mutational signatures identified in this study. In line with prior studies linking red meat consumption with cancer incidence in the distal colon, Giannakis and colleagues found that normal and cancerous tissue from the distal colon had significantly higher alkylating damage than tissue from the proximal colon.  Using a predictive model, the researchers identified the KRAS and PIK3CA genes as potential targets of alkylation-induced mutation. Consistent with this prediction, they found that colorectal tumors harboring KRAS G12D, KRAS G13D, or PIK3CA E545K driver mutations, which are commonly observed in colorectal cancer, had greater enrichment of the alkylating signature compared to tumors without these mutations. The alkylating signature was also associated with patient survival: Patients whose tumors had the highest levels of alkylating damage had a 47 percent greater risk of colorectal cancer-specific death compared to patients with lower levels of damage. Author's Comments: "Our study identified for the first time an alkylating mutational signature in colon cells and linked it to red meat consumption and cancer driver mutations," said Giannakis. "These findings suggest that red meat consumption may cause alkylating damage that leads to cancer-causing mutations in KRAS and PIK3CA, thereby promoting colorectal cancer development. Our data further support red meat intake as a risk factor for colorectal cancer and also provide opportunities to prevent, detect, and treat this disease."  Giannakis explained that if physicians could identify individuals who are genetically predisposed to accumulating alkylating damage, these individuals could be counseled to limit red meat intake as a form of precision prevention. In addition, the alkylating mutational signature could be used as a biomarker to identify patients at greater risk of developing colorectal cancer or to detect cancer at an early stage. Because of its association with patient survival, the alkylating signature may also have potential as a prognostic biomarker. However, future studies are needed to explore these possibilities, Giannakis noted. Study Limitations: A limitation of the study is the potential selection bias of study participants, as tissue specimens could not be retrieved from all incident colorectal cancer cases in the cohort studies. Current studies from Giannakis and his colleagues are exploring the potential role of red meat intake and alkylating damage in diverse groups of patients. Funding & Disclosures: The study was supported by the National Institutes of Health, the Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (co-administered by the AACR), the Project P Fund, the Cancer Research UK Grand Challenge Award, the Nodal Award from the Dana-Farber Harvard Cancer Center, the Friends of the Dana-Farber Cancer Institute, the Bennett Family Fund, and the Entertainment Industry Foundation through the National Colorectal Cancer Research Alliance and Stand Up To Cancer.  Giannakis has received research funding from Bristol-Myers Squibb, Merck, Servier, and Janssen unrelated to this study. Association of higher average daily polyphenol intake with Mediterranean diet adherence and decreased waist to hip circumference University of the Aegean (Greece), June 14, 2021 According to news reporting originating from the University of the Aegean research stated, “Research data indicate the possible effect of both polyphenols consumption and Mediterranean diet adherence on metabolic diseases' prevalence. The present retrospective study investigated the possible association of polyphenols mean daily intake with Mediterranean diet adherence and anthropometric indices in a sample of the Greek population.” Our news reporters obtained a quote from the research from University of the Aegean: “A total of 250 healthy volunteers, aged between 18 and 65 years, were randomly recruited from central and northern Greece. Total daily polyphenols intake was estimated using a semi-quantitative food frequency questionnaire (FFQ) based on the NHANES study, while Med Diet Score was used for the degree of Mediterranean diet adoption. Daily polyphenols intake was identified by the Phenol Explorer database, and anthropometric measurements (BMI, waist-to-hip circumference, and body composition) were performed. The mean daily polyphenols intake was determined to be 1905 mg, while most of the participants had moderate or high mean consumption last year (67.5% of the sample were consuming more than 1000 mg/d). Moderate adherence to the Mediterranean diet (higher Med Diet Score) was associated with increased mean daily polyphenols intake (* * p* * = 0.016). Increased polyphenols intake and higher Med Diet Score were associated with decreased waist-to-hip circumference (* * p* * = 0.027, 0.004, respectively).” According to the news editors, the research concluded: “Specific functional foods rich in polyphenols, such as sour cherry, tomatoes, black tea, and cocoa were associated with improved body composition indices. Larger epidemiological studies need to be performed for safer conclusions about whole population polyphenols intake and its association with metabolic disease biomarkers.” Whole, natural fiber works best to protect gut mucosal layer, researcher says University of Michigan, June 12, 2021 Dietary fiber plays an important role in protecting the gut's mucosal layer, according to research presented at the recent Probiota Americas event. It has long been known that the gut stays healthier and performs better with adequate fiber. But why? This is one of the questions that informed the research conducted by Dr Eric Martens, assistant professor of microbiology and immunology at the University of Michigan. Martens presented his research at the  IPA World Congress + Probiota Americas event, which was hosted by William Reed in Chicago last week. The event brought together 280 regulators, probiotics and prebiotics researchers and product developers.  Protecting the mucosal layer Martens said that his research showed that without adequate fiber in the gut, some organisms that might be nourished by that food source will look to alternative sources, one of which is the gut's mucosal layer. That layer is a critical component of the gut wall, and when it is eroded or absent harmful bacteria have an opportunity to latch onto the cells of the wall itself. “The core of our research is we are interested in the physiology of the many bacteria that live in the gut and defining at the functional and mechanistic level how they work with goal of understanding how the community works,” Martens said. The study he presented used 14 different bacteria with defined characteristics in a mouse model. The study had three groups, a group fed a fiber free diet, one with a whole grain diet rich in natural fibers, and a third that had fiber added back in in the form of purified, prebiotic fibers.  His research found that the whole grain, natural fibers fostered a microbial community in which the muscosa-eroding organisms were suppressed the best. He postulated that this could be because the large, whole food particles typical of the natural fiber diet were best able to reach the distal regions of the gut and affect the microbial community makeup there, whereas the purified fibers may have been mostly digested by that point. What Is the Liver Powerhouse Silymarin? GreenMedInfo  June 17th 2021   Here's what science has found most beneficial about silymarin, extracted from milk thistle and known to be a friend of your liver mainly through its antioxidant and anti-inflammatory properties When it comes to treating liver and gallbladder disorders, there is one name that stands out: silymarin. As a group of flavonolignans extracted from milk thistle, silymarin has been traditionally used for various protective benefits, from reinvigorating liver function to promoting breast milk production. The milk thistle plant, scientifically known as Silybum marianum, is a prickly plant with purple flowers and milky white veins present on the leaves, thus its name. Silymarin is the group of plant compounds that act as its active ingredient.[i] Silymarin is the main bioactive component of this medicinal plant. It is a mix of various flavonolignans, includings silybinin A and B, isosilybinin A and B, silychristin and silydianin.[ii] Milk thistle extract has a high silymarin content of approximately 65% to 80%. Silymarin is famed for its antioxidant, antiviral and anti-inflammatory components,[iii] as well as its traditional use or treating the liver and restoring its health. In addition, milk thistle itself is generally considered safe to take. Side effects are rare, and in an oral form standardized to contain 70% to 80% silymarin, it appears to be safe for up to 41 months of use.[iv] Silymarin's Liver-Protective Effects Fights liver inflammation and liver damage. Mounting evidence shows improvements in liver function among people with liver diseases who have taken a milk thistle supplement.[v] This suggests protection against flavanone silibinin liver inflammation and liver damage through use of the natural -- silymarin's primary active component -- which was combined with phosphatidylcholine in a specific study to enhance its solubility and bioavailability. Protects from toxins such as amatoxin, produced by Amanita mushroom, which can cause death if ingested. Two cases in the U.S. were treated with N-acetylcysteine, high-dose penicillin, cimetidine and silibinin.[vi] Uncontrolled trials and case reports cited successful treatment with intravenous silibinin, a flavonolignan isolated from milk thistle extracts, in nearly 1,500 cases.[vii] Overall mortality in those treated with the formula was less than 10%, compared to more than 20%when using penicillin, or a mix of silibinin and penicillin. Reduces liver fibrosis. In a randomized trial of 99 patients, the team administered silymarin in 700-milligram (mg) doses, or a placebo, given three times daily for 48 weeks.[viii] Non-alcoholic fatty liver disease (NAFLD) activity score was reduced by 32.7% in the silymarin group compared to 26% in the placebo group. Among the secondary outcomes were reductions in inflammation and fibrosis score in the silymarin group, leading the researchers to conclude that silymarin may decrease liver fibrosis, to be confirmed in larger trials. Fibrosis is the formation of abnormally large amounts of scar tissue in the liver. Helps prevent liver cancer. Studies have concluded that the long-term use of silymarin significantly increases survival time among patients with alcohol-induced liver cirrhosis, a risk factor for liver cancer. Silymarin can also significantly reduce tumor cell proliferation, angiogenesis or new blood vessel formation, as well as insulin resistance.[ix] The chemopreventive effects "have been established in several studies using in vitro and in vivo methods," according to the researchers, and combine well with anti-inflammatory and inhibitory effects on the metastasis or spread of cancer. Contributes to liver regeneration. An animal study suggested that silymarin played a crucial role in accelerating liver regeneration after liver resection, a kind of surgery designed to remove cancerous tumors from the liver.[x] Liver regeneration is thought to evolve to protect animals from loss of liver due to toxins or tissue injury. Silymarin for Breastfeeding, Neurological Support Not to be ignored is silymarin's formidable list of other health benefits, such as boosting milk production in lactating mothers. A randomized trial found that mothers taking 420 mg of silymarin for 63 days produced more breast milk than subjects who took a placebo.[xi] Silymarin combined with phosphatidylserine and galega also increased milk production in moms of preterm infants, without any significant side effects.[xii] Milk thistle is also a traditional remedy for neurological disorders such as Alzheimer'sand Parkinson's diseases. Its antioxidant and anti-inflammatory action mean it may be neuroprotective and help prevent the brain decline experienced with aging.

Tipping Point New Mexico
307 CD 1 Election Results Analysis, NM All Turquoise MLG Announces for Reelection, Student Athletes and Masks

Tipping Point New Mexico

Play Episode Listen Later Jun 8, 2021 48:59


On this week's podcasts discussion, Wally and Paul talk about Mark Moores getting clobbered 63% to 33% in the Congressional District 1 race; What went wrong? What does it mean? What does it mean for redistricting?  Paul gives "props" to Mayor Tim Keller for vetoing Albuquerque's gas tax; On COVID 19, all New Mexico counties are now in turquoise An Albuquerque Journal sports reporter had an important article over the weekend on Gov. Lujan Grisham's ongoing policy of demanding athletes wear masks in New Mexico. In continuing the sports theme, golfer Jon Rahm was forced to withdraw from the Memorial golf tournament over the weekend due to a positive COVID test and despite having no symptoms. Rahm was leading by a robust 6 strokes.  Paul provides a brief update on the ongoing CYFD story; Thankfully Fauci didn't delete emails like MLG has been. With half of all US states (all of them GOP-led) rejecting “$300 supplemental” unemployment benefits, the Federal Reserve indicates the policy is likely to get people back to work. The La Luz trail race is forced to cease. This makes radical environmentalists happy. Craziness ensues at two local campaign events. Mayoral candidate Manny Gonzales' event was disrupted by a drone outfitted with a sex toy followed by a physical attack. Gov. MLG (at her campaign launch) suffered taunts and protests. She then called her opponents lizard people & Q'Anon.

Elevator World
Elevator Industry Fourth Covid-19 Survey Results Analysis

Elevator World

Play Episode Listen Later Jun 3, 2021 5:43


Welcome to the Elevator World News Podcast. Today's podcast news podcast is sponsored by elevatorbooks.com: www.elevatorbooks.com ELEVATOR INDUSTRY FOURTH COVID-19 SURVEY RESULTS ANALYSIS Elevator World, Inc., the German elevator association VFA Interlift e.V. and fair organizer AFAG, in association with Credit Suisse, recently shared results of their fourth survey of elevator industry representatives on current industry status and future business outlook during the COVID-19 pandemic. The survey received nearly 400 responses, compared with 600 in the third iteration (ELENET 875), 572 in the second (ELENET 861) and 550 in the first. Credit Suisse Managing Director and Head of European Capital Goods Equity Research André Kukhnin assisted with preparation of a chart analysis, including breakdowns by country, of the results, including responses on the risk of rising raw materials costs to businesses in 2021. Image credit: by Miroslava Chrienova for Pixabay To read the full transcript of today's podcast, visit: elevatorworld.com/news Subscribe to the Podcast: iTunes │ Google Play | SoundCloud │ Stitcher │ TuneIn

Yadnya Investment Academy
Kotak Mahindra Bank Q4 FY21 Results Analysis

Yadnya Investment Academy

Play Episode Listen Later May 11, 2021 7:13


Kotak Mahindra Bank reported a 33% rise in Net profit to Rs.1,682 Cr for the Mar-21 quarter from Rs.1,267 Cr in Mar-20 last year. Though Net profit declined 9.3% QoQ on account of higher provisioning. Provisions and contingencies increased significantly QoQ by 181% to Rs.1,179 Cr in Mar-21 from Rs.419 Cr in Dec-20.

Yadnya Investment Academy
HCL Tech Q4 FY21 Results Analysis

Yadnya Investment Academy

Play Episode Listen Later Apr 29, 2021 4:12


HCL Tech Q4 FY21 Results Analysis

Yadnya Investment Academy
ICICI Bank Stock | Q4 FY21 Results Analysis

Yadnya Investment Academy

Play Episode Listen Later Apr 29, 2021 11:29


ICICI Bank Stock Q4 FY21 Results Analysis

More Plates More Dates
"Pro Footballers Don't Take PED's!" - André Onana Test Results Analysis

More Plates More Dates

Play Episode Listen Later Feb 7, 2021 18:12


Shellshocked
Election Results Analysis Update: The Vanguard

Shellshocked

Play Episode Listen Later Nov 24, 2020 23:47


George analyzes the most recent developments regarding the elections, both in terms of irregularities in the presidential race and the latest news on down ballot results and predictions. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/dj-trump/support

PB&J: Politics with Brian & Jake
Election Results Analysis

PB&J: Politics with Brian & Jake

Play Episode Listen Later Nov 9, 2020 69:13


Joe Biden will be the 46th President after winning by a slim margin in a few key battleground states. What do the results mean? Does Joe Biden have a mandate for big change or was this just a rejection of Trump?

WBGO Journal
New Jersey Election Results: Analysis from Eagleton Institute of Politics

WBGO Journal

Play Episode Listen Later Nov 7, 2020 21:01


Not all the local congressional races were called on Election Night but all three ballot questions were approved by voters in New Jersey. Voters approved the legalization of recreational marijuana in New Jersey To get a better perspective legalizing recreative marijuana as well as the local election results, WBGO’s Janice Kirkel spoke this week with John Weingart, Associate Director of the Eagleton Institute of Politics at Rutgers University.

Political Misfits
Protecting Voting Rights; New Hippocratic Oath Addresses Racism; Georgia Election Results Analysis

Political Misfits

Play Episode Listen Later Nov 7, 2020 112:54


Barbara Arnwine, president and founder of the Transformative Justice Coalition; and Rev. Dr. Sharon Anderson, CEO of KCG Consulting and former associate professor at the Howard University School of Law and Georgetown Law, join us to discuss the US presidential election, the courts and whether constant lawsuits over vote counting are the future for the country. Since the counting started, there have been a bunch of lawsuits, mostly by the Trump campaign, regarding access for observers. There have also been lawsuits in several states regarding which votes could be counted and what the results have been. Should we look at these legal fights launched by the Trump campaign and think that US election and voting laws are pretty weak and unsettled? Or, on the contrary, should we conclude that the laws and courts are functioning as they should, and these lawsuits are just harassment?Dr. Yolandra Hancock, board-certified pediatrician and obesity medicine specialist, joins us to discuss medical education during a pandemic and a new Hippocratic Oath that addresses racism. The new oath comes from the University of Pittsburgh School of Medicine's Class of 2024. In September, students in the class "started a new tradition by writing their own class oath to acknowledge their ever-evolving responsibilities as physicians," a release from the university noted. It acknowledges “the fundamental failings of our health care and political systems in serving vulnerable communities.” It is intended as a “first step in our enduring commitment to repairing the injustices against those historically ignored and abused in medicine: Black patients, Indigenous patients, Patients of Color and all marginalized populations who have received substandard care as a result of their identity and limited resources.” But what will the students taking this oath be up against as they try to uphold it while going through medical school and into their own practices?Anoa Changa, writer, activist, lawyer and journalist, joins us to discuss the elections in Georgia. The presidential race seems to be coming to a close, but the state will have not one but two US Senate seats heading to runoff elections on January 5, 2021. One race will be Republican Sen. David Perdue vs. Democrat Jon Ossoff, and the other race will be GOP Sen. Kelly Loeffler - who has never won an election - vs. Democratic Pastor Raphael Warnock. Just about every Democrat has come forward with advice on how best to win each seat. On one side, House Speaker Nancy Pelosi (D-CA) and her allies have warned Georgia Democrats to not run too far to the left, or they will blow their chances in both contests. House Majority Whip Jim Clyburn (D-SC) said during a Thursday caucus call that if “we are going to run on Medicare for All, defund the police, socialized medicine, we're not going to win," Politico reported. "But Rep. Pramila Jayapal of Washington, co-chair of the Congressional Progressive Caucus, thought differently, jumping in on a Democratic Party strategy call to defend liberal ideas, saying that’s what keeps the Democratic base motivated to turn out and vote," the outlet noted. How do Democrats win these two Senate seats in Georgia? What is the path?

The Michael Medved Show
Ep. 442 - Election results analysis

The Michael Medved Show

Play Episode Listen Later Nov 6, 2020 39:45


This is an abbreviated version of The Michael Medved Show. To get the full program, plus premium content, become a subscriber at MichaelMedved.com

Greater LA
Local results analysis 2 days after the election

Greater LA

Play Episode Listen Later Nov 6, 2020 24:11


LA County said this morning that it has counted more than 3.3 million ballots, with about 618,000 to go. KCRW gets a rundown of the results so far — including for district attorney, LA City Council and Board of Supervisors. What do the votes say about demographics, turnout, and trends. 

Houston Matters
Results, Analysis, And Your Thoughts On The Election (Nov. 4, 2020)

Houston Matters

Play Episode Listen Later Nov 4, 2020 49:19


  On Wednesday's show: We bring you the latest results from all the national, state, and local races. Plus local political scientists provide analysis of the results. And we welcome your thoughts on how it turned out.

marketfeed - The Stock Market Podcast
Reliance Q2 Results Analysis Stocks to Watch for Monday Nov 2 - The Stock Market Podcast E20

marketfeed - The Stock Market Podcast

Play Episode Listen Later Oct 30, 2020 31:13


Welcome to The Stock Market Podcast by Sharique Samsudheen. We meet here every day at 8.30 pm to discuss, analyze, and learn everything about the stock market. We start the day by analyzing the Nifty & Bank Nifty levels and go on to talk about top news for the day. We also discuss stocks to watch for tomorrow. Join Us on Telegram - Search @fundfolio on Telegram Do check out www.marketfeed.news for updates every day Sensibull Options Trading Platform Discount Link - https://rzp.io/l/fundfolio10 Open Demat & Trading Account with Zerodha - https://zerodha.com/open-account?c=ZMPKGJ Open Free Demat Trading Account With Upstox - https://upstox.com/open-account/?f=8U0X Do check out our video version - https://www.youtube.com/watch?v=Xs3WlBNC9xM Send in your valuable feedback to marketfeed@fundfolio.in

Elevator World
Elevator Industry Second Covid-19 Survey Results Analysis

Elevator World

Play Episode Listen Later Oct 21, 2020 6:18


Welcome to the Elevator World News Podcast. Today’s podcast news podcast is sponsored by elevatorbooks.com: www.elevatorbooks.com ELEVATOR INDUSTRY SECOND COVID-19 SURVEY RESULTS ANALYSIS Elevator World, Inc., the German elevator association VFA Interlift e.V. and fair organizer AFAG, in association with Credit Suisse, recently shared results of its second survey of elevator industry representatives on current industry status and anticipated effects of the COVID-19 pandemic on business. The survey received 572 responses, more than the first iteration that received 550 responses. Credit Suisse Managing Director and Head of European Capital Good Equity Research Andre Kukhnin assisted with preparation of a chart analysis, including breakdowns by country, of the results (excluding China, as, in July [ELENET 849], only a few of the responses were from that country, and an even comparison of previous and current results was needed). The most recent survey included a new question about the competitive environment that pointed to toughening competition globally across manufacturers, service providers and components suppliers. Additional observations include: • Respondents in Germany and North America were most positive, while those in Asia (excluding China), South America and the Middle East were most cautious. • Industry associations and consultants remain most cautious, while all divisions of the industry (component suppliers, manufacturers and service providers) have become positive. • Overall, the industry has become slightly less cautious, with 29% still expecting unfavorable development over the next six months (the same as in July), but with 24% now expecting favorable development (versus 19% previously). • Germany and North America both had improved outlooks compared to in July. Europe (excluding Germany) remained broadly unchanged in terms of negativity, while South America improved. • Outlook in Asia (excluding China) worsened slightly. • Consistent with July, uncertainty about economic policy remains a perceived limiting factor for business performance. • The level of concern about demand, financial constraints and materials/equipment shortages lessened slightly. • Employment outlook shifted from slightly negative in July to slightly positive. • Globally, business activity is expected to be 5% below pre-pandemic levels, with Germany most positive and nearly fully recovered and South America and Asia (excluding China) most negative, with business nearly 10% below pre-pandemic levels. Image credit: by Miroslava Chrienova for Pixabay To read the full transcript of today's podcast, visit: elevatorworld.com/news Subscribe to the Podcast: iTunes │ Google Play | SoundCloud │ Stitcher │ TuneIn

Sports Wagering Zone
Recap Mondays Betting Results - Analysis of the SEC - NBA Games Analysis

Sports Wagering Zone

Play Episode Listen Later Sep 15, 2020 33:01


Elevator World
Elevator Industry COVID-19 Survey Results Analysis

Elevator World

Play Episode Listen Later Jul 28, 2020 7:08


Welcome to the Elevator World News Podcast. Today’s podcast news podcast is sponsored by elevatorbooks.com: www.elevatorbooks.com ELEVATOR INDUSTRY COVID-19 SURVEY RESULTS ANALYSIS Elevator World, Inc.; the German elevator association VFA Interlift e.V. and fair organizer AFAG, in association with Credit Suisse, recently shared results of a survey of elevator industry representatives on the current industry status and anticipated effects of the COVID-19 pandemic on business. Credit Suisse Managing Director and Head of European Capital Goods Equity Research Andre Kukhnin assisted with preparation of a chart analysis, including breakdowns by country, of the results (excluding China, as only three of the nearly 600 responses were from that country). Calculating results using a method akin to the widely followed, evenly balanced Purchasing Manager Index, observations include: • Overall assessment of the current economic situation leans toward “challenging,” with 34% answering “bad,” 26%, “good” and the remaining 40% “neutral.” • Industry associations are most negative in their outlook versus pre-pandemic times • Manufacturers and service providers are least negative in their outlook versus pre-pandemic times • Overall, the industry outlook is slightly cautious, with 29% expecting unfavorable development over the next six months, half expecting stability and 19% expecting favorable development. Respondents from Europe and North America were less negative. • In terms of business outlook, industry associations are most cautious in their pandemic-era outlook, followed by manufacturers/components suppliers and consultants/service providers. • The most-cited business-limiting factor is COVID-19-related restrictions, followed by economic uncertainty and lagging demand. • Those in Europe and North America plan to maintain current levels of employment over the next three months, but those in the Asia-Pacific region do not. • New equipment providers in Europe anticipate business to be up to 10% below pre-COVID-19 levels, while modernization providers, expect the firms to be only 3% below previous levels. Image credit: by Gerd Altmann for Pixabay To read the full transcript of today's podcast, visit: elevatorworld.com/news Subscribe to the Podcast: iTunes │ Google Play | SoundCloud │ Stitcher │ TuneIn

TalkBrunch
385 Everyone Has News

TalkBrunch

Play Episode Listen Later May 26, 2020 200:03


- Honest Opinion on the Hana Kimura Tragedy - AEW Double or Nothing 2020 Review & Results - Analysis of Owen Heart: Dark Side of the Ring - Alexa Bliss Takes Offense to Podcaster Comments - Analyzing the Culture of Wrestling Contrarians - Understanding the Psychology of Cyber Bullying - Details on the Tragic Death of Shad Gaspard - Thoughts on Undertaker Last Ride Chapter 3 - Weekly Wrestling Rundown & Ratings - Injury Updates & More

Tarleton Radio
Cogley & Morrow: On Politics - Democratic Caucus results analysis, Congress Act, and More!

Tarleton Radio

Play Episode Listen Later Feb 17, 2020 52:23


This week on Cogley & Morrow On Politics, the duo discuss there full analysis of the most recent democratic primaries and caucuses. After this, they delve into a recent act passed by congress to condemn and restrict the presidents actions in the middle east. All this and more!You can join the conversation at facebook.com/cogleymorrow.

Cogley & Morrow: On Politics
2-14-2020: Democratic Caucus results analysis, Congress Act, and More!

Cogley & Morrow: On Politics

Play Episode Listen Later Feb 16, 2020 52:23


This week on Cogley & Morrow On Politics, the duo discuss there full analysis of the most recent democratic primaries and caucuses. After this, they delve into a recent act passed by congress to condemn and restrict the presidents actions in the middle east. All this and more!You can join the conversation at facebook.com/cogleymorrow.

Touch 'Em Up!
Episode 72 (Part 1): UFC 247 Results/Analysis! Was Reyes Robbed?/ UFC Fight Announcements! Zabit vs Ortega at 249?

Touch 'Em Up!

Play Episode Listen Later Feb 10, 2020 27:54


- On this part of Episode 72, we discuss the results of UFC 247: Jones vs Reyes, and Get into some very solid fight announcements for the UFC, including a BANGER for UFC 249 that is in the works!! So without any further a do, let's get this started and STEP INTO THE RING!!!! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/marc-m/support

Touch 'Em Up!
Episode 50: UFC Fight Night Moscow Results/Analysis, Booking the best fights at 145lbs!

Touch 'Em Up!

Play Episode Listen Later Nov 11, 2019 23:56


As it says in the title, going over the results of UFC FN 163:Moscow and booking the best fights possible at 145lbs from here on out! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/marc-m/support

Touch 'Em Up!
Episode 48 (Part 1): UFC 244 Masvidal vs Diaz Results/Analysis (Till comes up big in MW Debut, Luque/Thompson put on a clinic)

Touch 'Em Up!

Play Episode Listen Later Nov 4, 2019 29:41


- On this episode of the Touch 'Em Up podcast we break down the results from the UFC 244 card from Madison Square Garden in NYC. So without any further a do, let's get ready and STEP INTO THE RING!! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/marc-m/support

Touch 'Em Up!
Episode 25: UFC on ESPN 5 Results/Analysis. UFC Fight Night 156 Predictions and More!

Touch 'Em Up!

Play Episode Listen Later Aug 5, 2019 23:01


As it states in the title of the episode! We go over a lot, including Colby Covington's impressive win over Robbie Lawler this past weekend! I'm Double M, so get ready to Touch 'Em Up! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/marc-m/support

Radio Sweden
EU election results, analysis for Swedish parties, voter turnout up

Radio Sweden

Play Episode Listen Later May 27, 2019 2:13


Radio Sweden Daily brings you a roundup of the main news in Sweden on May 27th 2019. Producer/presenter: Frank Radosevich

Fantasy Best Friends Forever
Wild Card Weekend Results, Analysis and Breakdown!

Fantasy Best Friends Forever

Play Episode Listen Later Jan 7, 2019 57:19


As everyone expected, the underdogs reigned supreme throughout Wild Card Weekend! Gregg Sussman and Frank Stampfl breaks down everything that happened including the Eagles reigning supreme, Frank's Chargers surviving and annoying the Cowboys are still in it! #FNTSY #NFL #WildCard #Eagles #Cowboys #Chargers #Colts #Ravens #Bears #Seahawks #Texans #NickFoles #JoeFlacco #LamarJackson #CodyParkey #AmariCooper Learn more about your ad-choices at https://news.iheart.com/podcast-advertisers

Savage AF with Shang & Black Pedro
Ep 29: Midterm Election Results Analysis & Musical Guest Namek

Savage AF with Shang & Black Pedro

Play Episode Listen Later Nov 19, 2018 46:17


In this episode Shang and Black Pedro talk about the California Wildfires, the Midterm Election results, and interview musical guest and current freestyle champ on Power 106 Namek (@namek626) Follow Shang @ComedianShang, Black Pedro @BlackPedro and @ComedyPopUp for info on upcoming episodes.Like the facebook pages: https://www.facebook.com/SavageAFshow/https://www.facebook.com/ComedyPopUpLA/

Savage AF with Shang & Black Pedro
Ep 29: Midterm Election Results Analysis & Musical Guest Namek

Savage AF with Shang & Black Pedro

Play Episode Listen Later Nov 19, 2018 46:17


In this episode Shang and Black Pedro talk about the California Wildfires, the Midterm Election results, and interview musical guest and current freestyle champ on Power 106 Namek (@namek626) Follow Shang @ComedianShang, Black Pedro @BlackPedro and @ComedyPopUp for info on upcoming episodes.Like the facebook pages: https://www.facebook.com/SavageAFshow/https://www.facebook.com/ComedyPopUpLA/

MONEY FM 89.3 - The Breakfast Huddle with Elliott Danker, Manisha Tank and Finance Presenter Ryan Huang

On 13 Feb 2018 Singapore Airlines (SIA) posted a 62% jump in third-quarter net profit on the back of stronger operating profit. What lies ahead for SIA? MONEY FM 89.3 breaks down the numbers with Corrine Png, CEO of Crucial Perspectives.

The Rise Up, See Red podcast
2014 NFL Draft results: Analysis of the Arizona Cardinals and their selections

The Rise Up, See Red podcast

Play Episode Listen Later May 15, 2014 90:46


After a long, long wait, the NFL Draft is over and now it is time to start grading, analyzing and projecting. Jess and Seth talk about what the Arizona Cardinals did in this year's draft. They break down each pick and what they bring to the table. Were they good picks? Who could have been the picks instead? Who are the favorite and least favorite picks? What roles will they fill now and moving forward?They also talk about the league in general and the quarterbacks that were selected. Who came away with a good draft? Who didn't do so well? What quarterbacks landed in a good spot? Tune in for more draft talk. 

Medizin - Open Access LMU - Teil 17/22
Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

Medizin - Open Access LMU - Teil 17/22

Play Episode Listen Later Jan 1, 2010


Background: MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates peritoneal metastasis of ovarian tumors. Both sMUC16 and csMUC16 also protect cancer cells from cytotoxic responses of natural killer (NK) cells. In a previous study we demonstrated that sMUC16 binds to specific subset of NK cells. Here, we identify the csMUC16/sMUC16 binding partner expressed on immune cells. Results: Analysis of immune cells from the peripheral blood and peritoneal fluid of ovarian cancer patients indicates that in addition to NK cells, sMUC16 also binds to B cells and monocytes isolated from the peripheral blood and peritoneal fluid. I-type lectin, Siglec-9, is identified as the sMUC16 receptor on these immune cells. Siglec-9 is expressed on approximately 30-40% of CD16(pos)/CD56(dim) NK cells, 20-30% of B cells and > 95% of monocytes. sMUC16 binds to the majority of the Siglec-9(pos) NK cells, B cells and monocytes. sMUC16 is released from the immune cells following neuraminidase treatment. Siglec-9 transfected Jurkat cells and monocytes isolated from healthy donors bind to ovarian tumor cells via Siglec-9-csMUC16 interaction. Conclusions: Recent studies indicate that csMUC16 can act as an anti-adhesive agent that blocks tumor-immune cell interactions. Our results demonstrate that similar to other mucins, csMUC16 can also facilitate cell adhesion by interacting with a suitable binding partner such as mesothelin or Siglec-9. Siglec-9 is an inhibitory receptor that attenuates T cell and NK cell function. sMUC16/csMUC16-Siglec-9 binding likely mediates inhibition of anti-tumor immune responses.

Medizin - Open Access LMU - Teil 16/22
Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans

Medizin - Open Access LMU - Teil 16/22

Play Episode Listen Later Jan 1, 2009


Background: The Y-box binding protein 1 (YB-1) is considered to be one of the key regulators of transcription and translation. However, so far only limited knowledge exists regarding its cellular distribution in the adult brain. Results: Analysis of YB-1 immunolabelling as well as double-labelling with the neuronal marker NeuN in rat brain tissue revealed a predominant neuronal expression in the dentate gyrus, the cornu ammonis pyramidal cell layer, layer III of the piriform cortex as well as throughout all layers of the parahippocampal cortex. In the hilus of the hippocampus single neurons expressed YB-1. The neuronal expression pattern was comparable in the hippocampus and parahippocampal cortex of adult macaques and humans. Double-labelling of YB-1 with the endothelial cell marker Glut-1, the multidrug transporter P-glycoprotein, and the astrocytic marker GFAP did not indicate a co-localization. Following status epilepticus in rats, no induction of YB-1 occurred in brain capillary endothelial cells and neurons. Conclusion: In conclusion, our study demonstrates that YB-1 is predominantly expressed in neurons in the adult brain of rats, macaques and humans. Lack of a co-localization with Glut-1 and P-glycoprotein argues against a direct role of YB-1 in the regulation of blood-brain barrier P-glycoprotein.

Medizin - Open Access LMU - Teil 15/22
Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases

Medizin - Open Access LMU - Teil 15/22

Play Episode Listen Later Jan 1, 2008


Background: Paraneoplastic neurological syndromes (PNS) are indirect remote effects of cancer on the nervous system, often associated with the presence of specific serum antibodies. The most recently described PNS defining reactivity is anti-Ma/anti-Ta. Here we present 22 newly diagnosed patients with anti-Ma or anti-Ta reactivity, refine the associated clinical picture and review all published patients to date.Patients and methods: Patients were identified by testing for PNMA1 and PNMA2 antibodies by western blotting and indirect immunofluorescence. Clinical data were obtained either by referral of the patient or from the referring physicians.Results: Analysis of 22 new patients (14 anti-Ma, eight anti-Ta) confirmed that anti-Ta are usually found in young men with limbic encephalitis and testicular germ cell tumours who stabilise neurologically with long term survival after tumour treatment. Patients with anti-Ma were of either sex, middle-aged, presented with a range of tumours and neurological symptoms and had a limited response to treatment. Furthermore, we expanded the range of associated clinical features: (1) the peripheral nervous system may be involved; (2) an overlap with anti-Hu is possible; and (3) testicular tumour manifestation can be extragonadal or detectable only at orchiectomy.Conclusion: Refining and expanding the range of anti-Ma/anti-Ta associated neurological presentations and tumours clearly demonstrated that the distinction between anti-Ma and anti-Ta associated PNS is of high clinical relevance.