Sudden temporary weakening of the heart muscle
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Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses heart health and disease prevention with Professor Alan Rozanski from Mount Sinai Hospital. They emphasize the importance of understanding blood pressure, weight, and cholesterol to avoid heart disease, which is a significant issue in Australia. Rozanski shares insights from his extensive career in cardiac imaging and prevention, highlighting the six domains of health: physical health, emotional well-being, quality of thinking, social relationships, sense of purpose, and stress management. They explore the impact of mental stress on heart health and differentiate it from Takotsubo syndrome, or broken heart syndrome.
In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Steve Reiter explore various aspects of heart health and longevity. They discuss the effects of sweeteners on heart function, delve into Takotsubo syndrome, and highlight the importance of fitness metrics. The conversation also covers the role of GLP-1s in treating heart disease, the benefits of dietary salt substitutes, and innovative approaches to brain and heart health at Gladden Longevity in Dallas, TX. FOR THE AUDIENCE · Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ ! Takeaways · The heart responds directly to artificial sweeteners and sugar. · Eating can be stressful, impacting heart health. · Takotsubo syndrome, or broken heart syndrome, is on the rise. · Fitness metrics like push-ups can indicate heart health. · GLP-1 medications can aid in weight loss and heart health. · Potassium-rich foods can improve heart function and lower blood pressure. · Heart disease can be prevented with lifestyle changes. · Innovative treatments are emerging for brain and heart health. · Stress management is crucial for heart health. · Body composition is more important than weight alone. · Dementia might be optional. Chapters 00:00 Introduction to Longevity and Heart Health 01:54 The Impact of Sweeteners on Heart Function 07:55 Understanding Takotsubo Syndrome 18:04 Physical Fitness and Heart Health 23:00 The Role of GLP-1 in Heart Disease 26:51 Dietary Salt Substitutes and Heart Health 31:38 Innovations in Brain and Heart Health Articles, News and Supplements mentioned Heart Health SWEET TASTE RECEPTORS IN THE HEART: A NEW PATHWAY FOR CARDIAC REGULATION: https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://medicalxpress.com/news/2025-02-sweet-receptors-heart-pathway-cardiac.html&ved=2ahUKEwjz8aD7q9-LAxVwRzABHfm_I9gQFnoECBMQAQ&usg=AOvVaw1TchSQH8L0OOc0rbJ-24qx BROKEN HEART SYNDROME ON THE RISE IN WOMEN: https://psychcentral.com/news/broken-heart-syndrome-is-on-the-rise-in-women BROKEN HEART SYNDROME AFFECTING MEN THE WORST: https://www.tctmd.com/news/following-takotsubo-men-have-worse-outcomes-are-more-likely-die-women LATEST INSIGHTS AND QUESTIONS ABOUT TAKOTSUBO SYNDROME: https://www.acc.org/latest-in-cardiology/articles/2024/12/01/42/cover-story-takotsubo-syndrome-expanding-insights-unanswered-questions IF YOU CAN DO THIS MANY PUSH-UPS, YOUR HEART IS HEALTHIER THAN YOU THINK: https://www.eatthis.com/push-up-test-heart-health-check/ GLP-1 RAs MEDICATIONS BEING USED TO TREAT HEART DISEASE: https://www.theguardian.com/australia-news/2025/feb/18/weight-loss-drug-wegovy-approved-to-treat-heart-disease-in-overweight-and-obese-australian-patients-tga DIETARY SALT SUBSTITUTES TO PREVENT HEART ATTACK, STROKE AND DEATH: https://knowridge.com/2025/02/dietary-salt-substitutes-could-prevent-heart-attack-stroke-and-death/ Supplements GLADDEN LONGEVITY BLOOD-VESSEL FORMULA: https://gladdenlongevityshop.com/products/blood-vessel-formula?_pos=1&_psq=blood&_ss=e&_v=1.0 GLADDEN LONGEVITY ANTI-INFLAMMATORY SHROOM FORMULA: https://gladdenlongevityshop.com/products/anti-inflammatory-adaptogenic-mushrooms?_pos=2&_psq=SHROOM&_ss=e&_v=1.0 GLADDEN LONGEVITY MOLECULAR HYDROGEN: https://gladdenlongevityshop.com/collections/h2-products Send your Qs for future episodes! Email: podcast@gladdenlongevity.com Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
❤️ Bonjour,Bienvenue dans cet épisode consacré au syndrome de Tako-Tsubo, aussi appelé le syndrome du cœur brisé.
Takotsubo syndrome, or “broken heart syndrome,” is a temporary heart condition triggered by extreme emotional or physical stress. It has been romanticized in fiction, with characters like Padmé Amidala and King Lear seemingly dying of heartbreak. First documented in the 1960s, takotsubo syndrome primarily affects postmenopausal women and is characterized by the ballooning of the left ventricle. Guest: Bethany Brookshire - Science Writer and Host on the Podcast “Science for the People” Learn more about your ad choices. Visit megaphone.fm/adchoices
Can a broken heart be mended? Perhaps if we are talking about takotsubo cardiomyopathy - also called broken heart syndrome - which is stress-induced damage to the heart muscle. Ninety percent of the people with this heart syndrome are post-menopausal women whose symptoms occur after severe emotional or physical stress. Learn about it in this episode: https://bit.ly/4g9Ma8x In this Episode:03:04 - Obituaries My My Mother Wrote for Me When I was In My 20's07:21 - Feeding a Broken Heart: Chicken Tetrazzini 09:15 - Takotsubo Cardiomyopathy (TTS) -You Really Can Die from a Broken Heart24:22 - Epitaph by Merrit Maloy25:41 - OutroRelated Content:S4E18: How to Exorcise Depression and Anxiety with ExerciseS3E37: What Can a Mindfulness Practice Offer You?The Tao of IroningS1E23: Support GroupsS2E16: Big Girls Do CryS3E22: Why Do We Fear Death?S1E07: No Mud, No Lotus – What is the New Normal?Support the showGet show notes and resources at our website: every1dies.org. Facebook | Instagram | YouTube | mail@every1dies.org
Le mystère du syndrome du coeur briséConnu aussi sous le nom de syndrome de Takotsubo, le coeur brisé survient lors d'un choc émotionnel. Perte d'un être cher, une rupture amoureuse, ou même une surprise inattendue. L'onde de choc part de l'esprit et finit par ébranler le cœur. Cela modifie temporairement la capacité de ce dernier à pomper le sang.Le terme "cœur brisé" est souvent utilisé de manière métaphorique, mais pour de nombreuses personnes, cette souffrance est bien plus qu'une simple expression poétique.La douleur de la rupture amoureuse, par exemple, touche l'intimité la plus profonde de l'individu. Elle engendre des changements émotionnels mais aussi des répercussions biologiques. On appelle ca la douleurpsychique. Le cerveau humain n'arrive pas toujours à distinguer une douleur émotionnelle d'une douleur physique.Les événements déclencheurs du syndrome de Takotsubo ne sont pas toujours visibles à l'œil nu. Un stress chronique ou des émotions réprimées depuis longtemps peuvent jouer le rôle de bombes à retardement. Ce syndrome n'est pas seulement une maladie cardiaque, mais une réponse psychosomatique à une surcharge émotionnelle. Le cœur devient le réceptacle de nos chagrins, nos peurs et nos blessures.Renouer un dialogue entre l'esprit et le corpsLe syndrome du coeur brisé offre une opportunité unique : redonner la parole à notre psyché pour qu'elle s'exprime autrement que par le biais de la souffrance physique. Ainsi, il est intéressant d'explorer sa douleur émotionnelle via notamment la thérapie. Le but c'est de comprendre ce qui a déclenché la crise. L'acte même de reconnaître cette émotion allège la charge et la douleur.Ensuite, renforcer sa résilience émotionnelle. Apprendre à mieux gérer le stress et les chocs émotionnels est essentiel pour prévenir d'autresépisodes. Lynda suggère de se reconnecter avec son corps. Toutes les approches comme la pleine conscience, la relaxation ou encore le yoga calme l'axe coeur-cerveau.Autre piste: réparer les blessures du passé puisque dans certains cas le syndrome de Takotsubo est en lien avec un traumatisme ancien qui se réactive dans le présent. Les thérapies comme l'EMDR et l'hypnose aident à désamorcer ces déclencheurs inconscients.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.
Unser Herz kann nicht nur physisch, sondern auch emotional stark unter Stress geraten. Und das kann zu einer Sonderform der akuten Herzschwäche führen, deren Symptome denen eines Herzinfarktes ähneln. Vor allem Frauen nach der Menopause sind davon besonders häufig betroffen. Wie kommt es zu diesem Herzereignis? Und was hat das alles mit einer Tintenfischfalle zu tun? Das erläutert in dieser Folge der Kardiologe Prof. Michael Becker.
Why Australian women tend to have poorer cardiac disease outcomes than their male counterparts The intricacies of INOCA, ANOCA and MINOCA and how they are diagnosed Spontaneous coronary artery dissection and its outcomes Takotsubo cardiomyopathy: Diagnosis, treatment and potential recurrence Host: Dr Terri Foran | Total Time: 29 mins Expert: Dr Fiona Foo, Clinical and Interventional Cardiologist Register for our fortnightly FREE WEBCASTSEvery second Tuesday | 7:00pm-9:00pm AEDT Click here to register for the next oneSee omnystudio.com/listener for privacy information.
CardioNerds (Dr. Yoav Karpenshif – Chair of the CardioNerds Critical Care Cardiology Council) join Dr. Munim Khan, Dr. Shravani Gangidi, and Dr. Rachel Goodman from Tufts Medical Center's general cardiology fellowship program for hot pot in China Town in Boston. They discuss a case involving a patient who presented with stress cardiomyopathy leading to cardiogenic shock. Expert commentary is provided by Dr. Michael Faulx from the Cleveland Clinic. Notes were drafted by Dr. Rachel Goodman. A young woman presents with de novo heart-failure cardiogenic shock requiring temporary mechanical circulatory support who is found to have basal variant takotsubo cardiomyopathy. We review the definition and natural history of takotsubo cardiomyopathy, discuss initial evaluation and echocardiographic findings, and review theories regarding pathophysiology of the clinical syndrome. We also highlight complications of takotsubo cardiomyopathy, with a focus on left ventricular outflow obstruction, cardiogenic shock, and arrythmias. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls Takotsubo cardiomyopathy is defined as a reversible systolic dysfunction with wall motion abnormalities that do not follow a coronary vascular distribution. Takotsubo cardiomyopathy is a diagnosis of exclusion; patients often undergo coronary angiography to rule out epicardial coronary artery disease given an overlap in presentation and symptoms with acute myocardial infarction. There are multiple echocardiographic variants of takotsubo. Apical ballooning is the classic finding, but mid-ventricular, basal, and biventricular variants exist as well. Patients with takotsubo cardiomyopathy generally recover, but there are important complications to be aware of. These include arrhythmia, left ventricular outflow tract (LVOT) obstruction related to a hyperdynamic base in the context of apical ballooning, and cardiogenic shock. Patients with Impella devices are at risk of clot formation and stroke. Assessing the motor current can be a clue to what is happening at the level of the motor or screw. Notes What is Takotsubo Syndrome (TTS)? TTS is a syndrome characterized by acute heart failure without epicardial CAD with regional wall motion abnormalities seen on echocardiography that do not correspond to a coronary artery territory (see below).1 TTS classically develops following an acute stressor—this can be an emotional or physical stressor.1 An important feature of TTS is that the systolic dysfunction is reversible. The time frame of reversibility is variable, though generally hours to weeks.2 Epidemiologically, TTS has a predilection for post-menopausal women, however anyone can develop this syndrome.1 TTS is a diagnosis of exclusion. Coronary artery disease (acute coronary syndrome, spontaneous coronary artery dissection, coronary embolus, etc) should be excluded when considering TTS. Myocarditis is on the differential diagnosis. What are the echocardiographic findings of takotsubo cardiomyopathy? The classic echocardiographic findings of TTS is “apical ballooning,” which is a way of descripting basal hyperkinesis with mid- and apical hypokinesis, akinesis, or dyskinesis.3 There are multiple variants of TTS. The four most common are listed below:3(1) Apical ballooning (classic TTS)(2) Mid-ventricular variant(3) Basal variant (4) Focal variant Less common variants include the biventricular variant and the isolated right ventricular variant.3 Do patients with TTS generally have EKG changes or biomarker elevation? Patients often have elevated troponin, though the severity wall motion abnormalities seen on TTE i...
Neste episódio, os hosts do DozeCast (Mateus Prata e Victor Bemfica) exploram a complexa "Síndrome do Coração Partido", ou Takotsubo, que se apresenta como uma disfunção cardíaca temporária desencadeada por altos níveis de estresse. Abordando desde sua descoberta no Japão até as teorias mais atuais sobre a fisiopatogênese, passando pelo diagnóstico e enfim as peculiaridades do tratamento. Acompanhe e entenda por que esta condição, mais comum em mulheres após a menopausa, desafia o diagnóstico médico e exige um olhar atento para evitar complicações. _____________________________ Atualizacões e revisões didáticas e leves, semanalmente . DozeNews PRIME: A maneira mais leve é rápida de se manter atualizado(a) através do link dozeporoito.com/prime Ainda não se inscreveu no nosso preparatório para a prova de Título de Especialista em Cardiologia? Ainda da tempo de ser aprovado! Acesse https://www.medway.com.br/cursos/dozetec/
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper about the evaluation of recurrent Takotsubo syndrome.
Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on repolarization injury and occurrence of Torsades de Pointes during acute Takotsubo syndrome.
santé-vous bien : Takotsubo et cannabis ; Top cuisine : agar-agar ; Oeil pour oeil : pleurer comme une madeleine
santé-vous bien : Takotsubo et cannabis ; Top cuisine : agar-agar ; Oeil pour oeil : pleurer comme une madeleine
Takotsubo é um tipo de miocardiopatia? by Cardiopapers
In the September 24, 2024 issue of JACC, Dr. Valentin Fuster explores a pivotal study on Takotsubo Syndrome, revealing significant shifts in patient demographics, trigger types, and outcomes over nearly two decades. The research highlights an increase in physical triggers and short-term mortality, reflecting a more complex and severe understanding of the condition than previously recognized.
In the September 24, 2024 issue of JACC, Dr. Manuel Almendro Odelia and Dr. Ivan Nunet Hill present groundbreaking research on Takotsubo syndrome, revealing that delayed recovery of left ventricular function significantly worsens both short and long-term survival. The study, based on data from the extensive RITACCO registry, identifies key predictors of slow recovery and underscores the need for closer follow-up in affected patients, challenging traditional treatment approaches and highlighting the evolving understanding of this complex condition.
In this episode, Dr. Valentin Fuster highlights key studies from the September 24, 2024 issue of JACC, featuring groundbreaking research on the impact of cold temperatures on myocardial infarctions, the nuanced recovery process in Takotsubo syndrome, and evolving trends in the condition. Also discussed are novel insights into predicting long-term outcomes for recurrent pericarditis and the influence of obstructive sleep apnea on cardiovascular health.
Dr. Manlio Fabio Márquez, médico espevcialista en Cardiología
¿Cuántos de ustedes no han sentido que se les rompe el corazón cuando han tenido una decepción amorosa? Pues ¡es real! Hoy les explicamos qué es el síndrome de corazón roto o Síndrome de TakoTsubo. Hosted on Acast. See acast.com/privacy for more information.
¿Cuántos de ustedes no han sentido que se les rompe el corazón cuando han tenido una decepción amorosa? Pues ¡es real! Hoy les explicamos qué es el síndrome de corazón roto o Síndrome de TakoTsubo. Hosted on Acast. See acast.com/privacy for more information.
In this episode, Yvonne sits down with Dr. Jonathan Fisher cardiologist and author of Just One Heart join Yvonne. They discuss how emotions affect the heart. Jonathan shares the latest research which demonstrates that intense emotions can physically change the shape of the heart and lead to heart attack like symptoms. They also discuss the importance of developing and maintaining empathy and connection to others. Johnathan explains that the heart has 4 dimensions – the emotional, physical, social, and spiritual hearts. All 4 play an important role in keeping your heart healthy. KEY TAKEAWAYS The heart is not just about the physical systems like blood flow, stress and other emotions also impacts how it works. Research shows that intense emotions can produce the symptoms of a heart attack. It is called Takotsubo cardiomyopathy or broken heart syndrome. Fortunately, just as stress and loss can break our hearts, positive emotions can help our hearts to function better. Jonathan explains how to tap into this. The fast pace we live at is leading us to lose our connection with others, which is bad for our physical health. Covid can impact the nervous system which plays a role in how the heart functions. The loss and emotional stress people felt are also still impacting some people´s heart health. When you remember something bad that happened it reactivates the physical sensations associated with that pain. Life is short. You can be healthy one day and seriously ill the next. That is why you should do what gives you purpose and meaning. When you manifest or visualise, you are training the neural pathways that affect the way our bodies move and function. It is good for our health. BEST MOMENTS ‘At least 60% of what I see as a heart doctor relates to either unaddressed or poorly addressed underlying stress because of what is going on in the world. ´ ‘We have to learn to listen to our bodies, to sit quietly and tune in.' ‘It is wise to recognise that and to limit the intake into our nervous system of this information.' EPISODE AND GUEST RESOURCES Just One Heart by Jonathan Fisher - https://www.amazon.co.uk/Just-One-Heart-Cardiologists-Happiness-ebook/dp/B0D1526W7D Barbara Fredrickson positive and negative emotions research - https://pubmed.ncbi.nlm.nih.gov/20363063/ https://brenebrown.com/ VALUABLE RESOURCES Website: pausepenny.com Instagram: @yvonnetchrakian_manifest @pause.penny LinkedIn: https://www.linkedin.com/in/yvonne-tchrakian-64257619/ HOST BIO Yvonne started her career as a corporate lawyer for one of Ireland's top law firms. After the loss of a baby during pregnancy, Yvonne founded Pause. Penny - which was created to inspire people to manifest their dream lives. She is also a mom of four. Yvonne is a serial manifester, manifesting everything from her dream jobs (yes, multiple), her soulmate, dream house and even her twins! Podcast Description This podcast is all about manifesting your dream life. Interviews with incredible entrepreneurs who are using manifestation to create successful businesses and solo episodes on how to start manifesting everything you desire. Yvonne teaches you 7 simple steps to manifesting your dream life, shares her own personal manifestation stories and gives practical advice on how to make manifestation a lifestyle. Tune in and I guarantee you will be manifesting your dreams!
Contributor: Ricky Dhaliwal, MD Educational Pearls: Takotsubo cardiomyopathy, also known as "broken heart syndrome,” is a temporary heart condition that can mimic the symptoms of a heart attack, including troponin elevations and mimic STEMI on ECG. The exact cause is not fully understood, but it is often triggered by severe emotional or physical stress. The stress can lead to a surge of catecholamines which affects the heart (multivessel spasm/paralysed myocardium). The name "Takotsubo" comes from the Japanese term for a type of octopus trap, as the left ventricle takes on a distinctive shape resembling this trap during systole. The LV is dilated and part of the wall becomes akenetic. These changes can be seen on ultrasound. The population most at risk for Takotsubo are post-menopausal women. Coronary angiography is one of the only ways to differentiate Takotsubo from other acute coronary syndromes. Most people with Takotsubo cardiomyopathy recover fully. References Amin, H. Z., Amin, L. Z., & Pradipta, A. (2020). Takotsubo Cardiomyopathy: A Brief Review. Journal of medicine and life, 13(1), 3–7. https://doi.org/10.25122/jml-2018-0067 Bossone, E., Savarese, G., Ferrara, F., Citro, R., Mosca, S., Musella, F., Limongelli, G., Manfredini, R., Cittadini, A., & Perrone Filardi, P. (2013). Takotsubo cardiomyopathy: overview. Heart failure clinics, 9(2), 249–x. https://doi.org/10.1016/j.hfc.2012.12.015 Dawson D. K. (2018). Acute stress-induced (takotsubo) cardiomyopathy. Heart (British Cardiac Society), 104(2), 96–102. https://doi.org/10.1136/heartjnl-2017-311579 Kida, K., Akashi, Y. J., Fazio, G., & Novo, S. (2010). Takotsubo cardiomyopathy. Current pharmaceutical design, 16(26), 2910–2917. https://doi.org/10.2174/138161210793176509 Summarized by Jeffrey Olson MS2 | Edited by Jorge Chalit, OMSII
Takotsubo cardiomyopathy, also known as “broken heart syndrome,” is hard to diagnose because its symptoms mimic more common conditions like acute coronary syndrome. This stress-induced cardiomyopathy presents a mysterious challenge to nurses, as you'll hear in today's patient story.Host Sarah Lorenzini shares the case of a patient who went from experiencing shortness of breath and nausea to a serious cardiac emergency. She breaks down the patient's initial presentation, their quick decline featuring hypoxia and flash pulmonary edema, and ultimate diagnosis of takotsubo cardiomyopathy.In this episode, Sarah dives into the pathophysiology of takotsubo cardiomyopathy, covering how emotional or physical stress leads to the condition. She goes over its symptoms and treatment, as well as the role of nurses in managing the condition.Tune in now to find out how you should be handling similar cardiac emergencies!Topics discussed in this episode:Takotsubo cardiomyopathy: a patient case studyThe pathophysiology of takotsubo cardiomyopathyDiagnosing takotsubo cardiomyopathyHow to effectively treat takotsubo cardiomyopathyFinal takeaways for nursesListen to Episode 82: Sympathetic Crashing Acute Pulmonary Edema: That Time My Patient Went From Stable A-Fib RVR to Intubated in 30 Minutes! https://podcasts.apple.com/ca/podcast/82-sympathetic-crashing-acute-pulmonary-edema-that/id1535997752?i=1000637926574Mentioned in this episode:AND If you are planning to sit for your CCRN and would like to take the Critical Care Academy CCRN prep course you can visit https://www.ccrnacademy.com and use coupon code RAPID10 to get 10% off the cost of the course!Rapid Response and Rescue Intro CourseCONNECT
DISCLAMER >>>>>> The Ditch Lab Coat podcast serves solely for general informational purposes and does not serve as a substitute for professional medical services such as medicine or nursing. It does not establish a doctor/patient relationship, and the use of information from the podcast or linked materials is at the user's own risk. The content does not aim to replace professional medical advice, diagnosis, or treatment, and users should promptly seek guidance from healthcare professionals for any medical conditions. >>>>>> The expressed opinions belong solely to the hosts and guests, and they do not necessarily reflect the views or opinions of the Hospitals, Clinics, Universities, or any other organization associated with the host or guests. Disclosures: Ditch The Lab Coat podcast is produced by (Podkind.co) and is independent of Dr. Bonta's teaching and research roles at McMaster University, Temerty Faculty of Medicine and Queens University. Welcome back to "Ditch the Labcoat," where today we debunked heart health myths with the remarkable Dr. Michael Ward. Did you know stress can literally break your heart? Dr. Ward broke down the realities of Takatsubo cardiomyopathy, stressed the importance of timely intervention in heart attacks, and shared his insights on the Mediterranean diet for cardiac wellness. Plus, we got a glimpse into the high-stakes world of interventional cardiology—straight from the operation room. Stay heart-smart and catch the full episode for a deep dive into the art and science of keeping your ticker ticking! Remember, a healthy heart is a healthy start. Don't miss it!00:00:03 Understanding Takotsubo Cardiomyopathy and Broken Heart Syndrome with Dr. Michael WardDr. Mark Bonta discusses Takotsubo cardiomyopathy, also known as broken heart syndrome, with Dr. Michael Ward. They explore how the condition is often triggered by emotional stress, such as the loss of a loved one, leading to acute heart failure.00:01:03 Discussion on the Heart as a Muscle and Cardiac ConditionsDr. Michael Ward discusses the heart as a muscle that pumps and the various cardiac conditions patients may face, such as heart attacks, heart failure, and heart rhythm problems. The conversation emphasizes the importance of understanding the basic function of the heart for better management of cardiac health.00:02:26 Discussion with Dr. Michael Ward on Interventional Cardiology and Hypertrophic CardiomyopathyDr. Michael Ward is an expert in interventional cardiology who helps people prevent and recover from heart-related issues. He also focuses on hypertrophic cardiomyopathy, a genetic condition affecting the heart. With a background in both medicine and research, he is a valuable asset at Western University in London, Ontario.00:03:50 Interview with Dr Michael Ward, Interventional CardiologistDr. Michael Ward, an interventional cardiologist with both an MD and a PhD, discusses his background in cell-based gene therapy and his interest in cardiovascular medicine. He shares insights on heart health, the importance of vacations for mental health, and his balanced lifestyle.00:07:18 Insight into the Fascinating Aspects of the Heart from an Interventional Cardiology PerspectiveDr Mark Bonta, an interventional cardiologist, shares his perspective on the intricate nature of the heart, highlighting how it responds to various stimuli and stressors. He emphasizes the role of the cardiovascular system in determining life and death outcomes and the potential for improving quality of life through cardiology interventions.00:11:14 Discussion on Interventional CardiologyDr. Mark Bonta discusses their work in interventional cardiology, including responding to emergencies like heart attacks and performing procedures in the catheterization laboratory. They describe the challenges faced by patients with heart conditions and the range of cases they handle.00:13:26 Understanding Cardiovascular System with Dr. Michael WardDr. Michael Ward talks about atherosclerosis as the accumulation of plaque in the arteries, which can lead to heart issues like angina and heart attacks. The discussion also touches on the difference between chronic accumulation of plaque and acute blockages causing heart attacks.00:18:01 Understanding Acute Heart Attacks and Plaque Ruptures in ArteriesAcute heart attacks can occur when plaque ruptures inside an artery, leading to a clot that blocks the artery and causes the heart attack. Platelets play a crucial role in responding to the rupture and forming clots to heal the affected area.00:19:44 Importance of Timely Intervention in Heart AttacksDuring a conversation between Dr. Mark Bonta and Dr. Michael Ward Interventional Cardiology, they discussed the critical importance of timely intervention in heart attacks. Dr. Bonta mentioned that when a heart attack occurs, time is of the essence as the muscle of the heart is deprived of blood flow. Historically, patients were given aspirin and blood thinners but no interventional procedures were done immediately.00:21:20 Advanced Cardiac Care Protocols in CanadaIn Canada, there are advanced protocols in place for managing ST-elevation myocardial infarction (STEMI) cases, including direct ambulance transportation to hospitals with cath labs. Time is crucial in treating cardiac emergencies to minimize heart muscle damage.00:23:51 Patient Experience in the Cath Lab: What to ExpectThe patient experience in the cath lab involves inserting a needle with a wire into their arteries, either through the wrists or groin. Patients may not feel much during the procedure, but there might be some sensations of discomfort or awareness of the procedure taking place.00:26:56 Understanding the Process of Opening Blocked Heart VesselsIn the conversation between Dr Mark Bonta and Dr Michael Ward Interventional Cardiology, they discuss the process of opening blocked heart vessels during angioplasty procedures. They talk about using topical lidocaine for anesthesia and how temporary discomfort may be felt when the blockage is being opened up. Dr Ward explains that a stent is not a rigid pipe but a meshwork that is placed in the living system of the coronary artery.00:29:41 Understanding Interventional Cardiology and StentingInterventional cardiology involves using contrast dye and x-ray cameras to map arteries and identify blockages. Stents are used to provide support and prevent arteries from narrowing, improving blood flow to the heart muscle. The decision to place a stent is based on the degree of blockage and the impact on blood flow.00:34:10 Discussion on Heart Health Interventions and Medical ManagementThe conversation between Dr. Mark Bonta and Dr. Michael Ward Interventional Cardiology delves into the topic of heart health interventions and the importance of medical management in cardiac care. They discuss the limitations of interventions like stents in treating moderate blockages and emphasize the significance of lifestyle changes and medications in preventing heart attacks and strokes.00:38:32 Preventing Cardiovascular Disease Through Exercise and MedicationsDr. Mark ...
Viene Manlio Fabio Márquez a hablarnos sobre el Síndrome de TakoTsubo y cómo es que, literalmente, se te puede romper el corazón ¿Cuántos de ustedes no han sentido que se les rompe el corazón cuando han tenido una decepción amorosa? Pues ¡es real! Hoy les explicamos qué es el síndrome de corazón roto o Síndrome de TakoTsubo. Hosted on Acast. See acast.com/privacy for more information.
Commentary by Dr. Candice Silversides
Impact: Mortality After Takotsubo – Comparison With MI and General Population
*Blame it on the Rain: Bob Enyart was an advocate for research into earthquake prediction and preparation. He knew the Earth is young, and its crust is unstable, and therefore governments should be in the business of figuring out how to more accurately predict earthquakes by, among other things, examining how the weather works with other factors to trigger seismic events! *Owner of a Broken Heart: Find out how an octopus trap, and Valentine's Day combine for a medical diagnosis you never want to hear! *Life & Marriage: Hear about a study confirming that married men live longer! *The Grand Tour: Dr. James Tour is a synthetic organic chemist, with a Bachelor in chemistry from Syracuse, a Ph.D. in synthetic organic and organometallic chemistry from Purdue, and postdoctoral training in synthetic organic chemistry at the University of Wisconsin and Stanford, almost 800 research publications, over 130 patents (& another 100 pending). Dr. Tour also has a strong presence on YouTube, and an offer for anyone who is not a believer to hear how he became believer in the physical resurrection of Jesus Christ. *Cancer & Molecular Jackhammers: Hear Dr. Tour describe his work in cancer research using nano-machines and light! And pair this show with our interview with Dr. Thomas Seyfried on Cancer as a metabolic disease. *Graphene, Recycling & Catching the Falling Sky: You'll hear about Dr. Tour's exciting work researching less expensive ways to produce graphene, (a substance we've discussed here on RSR), his research into methods for recycling electronic waste, and more efficient ways for hysterical materialists to capture all the carbon dioxide they want! *Professing the Gospel: If you are unconvinced of the physical resurrection of Jesus Christ, Dr. Tour wants to hear from you!
*Blame it on the Rain: Bob Enyart was an advocate for research into earthquake prediction and preparation. He knew the Earth is young, and its crust is unstable, and therefore governments should be in the business of figuring out how to more accurately predict earthquakes by, among other things, examining how the weather works with other factors to trigger seismic events! *Owner of a Broken Heart: Find out how an octopus trap, and Valentine's Day combine for a medical diagnosis you never want to hear! *Life & Marriage: Hear about a study confirming that married men live longer! *The Grand Tour: Dr. James Tour is a synthetic organic chemist, with a Bachelor in chemistry from Syracuse, a Ph.D. in synthetic organic and organometallic chemistry from Purdue, and postdoctoral training in synthetic organic chemistry at the University of Wisconsin and Stanford, almost 800 research publications, over 130 patents (& another 100 pending). Dr. Tour also has a strong presence on YouTube, and an offer for anyone who is not a believer to hear how he became believer in the physical resurrection of Jesus Christ. *Cancer & Molecular Jackhammers: Hear Dr. Tour describe his work in cancer research using nano-machines and light! And pair this show with our interview with Dr. Thomas Seyfried on Cancer as a metabolic disease. *Graphene, Recycling & Catching the Falling Sky: You'll hear about Dr. Tour's exciting work researching less expensive ways to produce graphene, (a substance we've discussed here on RSR), his research into methods for recycling electronic waste, and more efficient ways for hysterical materialists to capture all the carbon dioxide they want! *Professing the Gospel: If you are unconvinced of the physical resurrection of Jesus Christ, Dr. Tour wants to hear from you!
Grab your hot chips and get ready to film it for TikTok. Might want to give this a listen first tho...we're counting down the days to the resident inservice exam, so let's cover a strange, rare pathology that gets everyone excited. Want to experience the greatest in board studying? Check out our interactive question bank podcast- the FIRST of its kind here. Cite this podcast as: Briggs, Blake; Husain, Iltifat. 212. Takotsubo: hot chip challenge. February 12th, 2024. Accessed [date].
MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: August 23, 2018 When the heart stops working, the brain stops working. But if the brain stops working, does the heart shut down? In this episode, Dr. David Manly (Duke Cardiology) discusses the pathogenesis and management of the reversible syndromes of neurogenic stress cardiomyopathy. In full disclosure, this is a re-mastered re-run of a prior episode posted June 29, 2016, with some updates at the end. Produced by James E Siegler. Music by Lee Rosevere. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. REFERENCES Banki NM, Kopelnik A, Dae MW, et al. Acute neurocardiogenic injury after subarachnoid hemorrhage. Circulation 2005;112(21):3314-9. PMID 16286583Bybee KA, Prasad A. Stress-related cardiomyopathy syndromes. Circulation 2008;118(4):397-409. PMID 18645066Eitel I, von Knobelsdorff-Brenkenhoff F, Bernhardt P, et al. Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy. JAMA 2011;306(3):277-86. PMID 21771988Finsterer J, Wahbi K. CNS-disease affecting the heart: brain-heart disorders. J Neurol Sci 2014;345(1-2):8-14. PMID 25034054Grabowski A, Kilian J, Strank C, Cieslinski G, Meyding-Lamadé U. Takotsubo cardiomyopathy--a rare cause of cardioembolic stroke. Cerebrovasc Dis 2007;24(1):146-8. PMID 17565206Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE. Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med 2008;5(1):22-9. PMID 18094670Paur H, Wright PT, Sikkel MB, et al. High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy. Circulation 2012;126(6):697-706. PMID 22732314Stiermaier T, Moeller C, Oehler K, et al. Long-term excess mortality in takotsubo cardiomyopathy: predictors, causes and clinical consequences. Eur J Heart Fail 2016;18(6):650-6. PMID 26990821Yoshimura S, Toyoda K, Ohara T, et al. Takotsubo cardiomyopathy in acute ischemic stroke. Ann Neurol 2008;64(5):547-54. PMID 18688801 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.
In this "Giant Mess", Neal Lynch talks about his first time at Topgolf, a boozy brunch date in Philly, a fantasy football draft weekend in the Poconos, Broken Heart Syndrome, the Mets retiring Doc Gooden and Darryl Strawberry's numbers, the debate over extending Pete Alonso or trading him in the offseason, the Giants trade for Isaiah Simmons, and Big Blue roster cuts. ABOUT "GIANT MESS": "Giant Mess" is a sloppy sports and entertainment talk show about New York Giants football, Mets baseball, movies, TV shows, funny stories and life lessons. It's hosted by a giant mess, The Real Cinch Neal Lynch. ABOUT NEAL LYNCH: I'm an Irish-Italian-American who graduated from a Catholic high school (but isn't Catholic), and a college known for producing doctors and lacrosse players, then became neither. Instead, I'm a former college quarterback & pitcher with a film and media studies degree who currently overthinks everything. Subscribe to Giant Mess on YouTube: https://bit.ly/GiantMessYT Follow me on: My Official Blog - http://bit.ly/neallynchBLOG Giant Mess Facebook Page - http://bit.ly/GiantMessFB Twitter - http://bit.ly/NealLynchTW Instagram - http://bit.ly/NealLynchIG Subscribe to Giant Mess on Apple Podcasts - http://bit.ly/GiantMessApple Subscribe to Giant Mess on Spotify - http://bit.ly/GiantMessSpotify --- Send in a voice message: https://podcasters.spotify.com/pod/show/neal-lynch/message
With Otto Smiseth & Lars-Egil Hammersboen, University of Oslo, Oslo - Norway Link to paper Link to editorial
Today, I am blessed to have Dr. Philip Ovadia. He is a board-certified Cardiac Surgeon and the founder of Ovadia Heart Health. From his personal experience, he made a goal to maintain his patients' metabolic health and keep them off the surgery table. Despite being a surgeon, Dr Philip is overweight. Whatever effort he makes following the recommendation of the flawed medical system, he remains overweight. But with the help of his wife, Dr. Philip began to take action, search for the truth, and eventually reach his goal of being metabolically healthy. Now, Dr. Philip made it his mission to help people fix their metabolic weight. With his knowledge and experience, he will do anything to awaken people from our current flawed medical system. Dr. Philip is also the author of the book Stay off My Operating Table: A Heart Surgeon's Metabolic Health Guide to Lose Weight, Prevent Disease, and Feel Your Best Every Day. In this episode, Dr. Philip Ovadia discusses how heart disease started and the factor that causes heart disease. He also talks about how stress can trigger heart disease. Furthermore, Dr. Philip shared his knowledge about why it is important to have lab tests, the truth about fish oil, and the diet we should have to achieve a metabolically healthy body. Tune in as we chat about heart disease, cholesterol, stress, lab test, fish oil, proper diet, and many more! Get Dr Philip Ovadia's book Stay Off My Operating Table Here: https://www.amazon.com/Stay-off-Operating-Table-Metabolic-ebook/dp/B09GL4S6G4/benazadi-20 Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E S P ON S O R S Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [01:05] Heart Disease: The History of How The Leading Killer Disease Worldwide Began - In the early 1900s, heart disease is an exceedingly rare condition. - Eventually, it became more prominent, and in the 1950s, it reached a crisis point. - 70 years later, the solution to fight heart disease still has yet to progress. - Cholesterol was not the problem. [15:14] What Is the One Factor That Causes Heart Disease? Know Your Risk - Heart disease is not multifactorial. It just has one factor that contributes to heart disease. - In atherosclerotic heart disease, damage to the blood vessel wall is a primary contributing component. - These damages to the blood vessel are caused by common factors such as insulin resistance, smoking, and high blood pressure. - Vegetable and seed oils are also a contributor to heart disease. [24:49] What's the Connection Between Being Stressed and Heart Disease? What Should You Do? - Stress plays an important role in heart disease, and it's one of the pillars of health - The difficult part about stress is we don't have a great way of measuring it. - There's a cardiac condition called Takotsubo cardiomyopathy, a stress-induced heart attack. - Managing stress is a very important aspect of mitigating your risk for heart disease. [28:19] Lab Test: The Importance of Getting a Lab Assessment Into Our Bodies - The amount of cholesterol isn't the right thing to look at. We need to look at the quality of the cholesterol in our bodies. - Until you get damage to the blood vessel and the cholesterol particles, you cannot produce heart disease and plaques in the heart's blood vessels. - Push to get an NMR panel. It is not expensive and is usually covered by insurance. - You need to know a doctor who knows what they're looking at. - One test that is essential for people to get is called a coronary artery calcium scan. That scan will show us whether or not you're accumulating damage to the blood vessels in your heart. - High sensitivity C reactive protein test is another important scan patients should have. [49:57] Have You Heard About Fish Oil? Should We Take It or Not? - The reason that fish oil gets recommended is because it's thought to be anti-inflammatory. - Dr. Philip advocates for people to figure out what's causing the inflammation and eliminate the inflammation. And then we don't need anti-inflammatories like fish oil anymore. - if you aren't oxidizing things in the first place and if you aren't first inducing inflammation. Anti-inflammatory drugs and antioxidants are not necessary. - Get on a low-inflammatory lifestyle and diet; you don't need the anti-inflammatory benefits. [54:22] You are What You Eat: What Diet Should You Have to Be Metabolically Healthy? - Eat whole real food. Since the introduction of processed food, our health has worsened. - Balance your diet between eating whole real animal proteins and whole real vegetables, plants, and fruits. - Different diet strategies each have their benefits and drawbacks. - If you feel metabolically healthy in your chosen diet, continue it. If not, changes are needed to be made. AND MUCH MORE! Resources from this episode: ● Dr. Philip Ovadia's Website: https://ovadiahearthealth.com/ ● I Fix Hearts Website: https://ifixhearts.com/ ● Follow Dr. Philip Ovadia ● Instagram: https://www.instagram.com/ovadia_heart_health/?hl=en ● Twitter: https://twitter.com/ifixhearts?s=20 ● YouTube: https://www.youtube.com/@IFixHearts/videos ● LinkedIn: https://www.linkedin.com/in/philip-ovadia-heart-health/ ● Get Dr Philip Ovadia's book Stay Off My Operating Table Here: https://www.amazon.com/Stay-off-Operating-Table-Metabolic-ebook/dp/B09GL4S6G4/benazadi-20 ● Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a ● Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/ / / E P I S O D E S P ON S O R S Wild Pastures: $20 OFF per Box for Life + Free Shipping for Life + $15 OFF your 1st Box! https://wildpastures.com/promos/save-20-for-life-lf?oid=6&affid=132&source_id=podcast&sub1=ad BonCharge: Blue light Blocking Glasses, Red Light Therapy, Sauna Blankets & More. Visit https://boncharge.com/pages/ketokamp and use the coupon code KETOKAMP for 15% off your order. Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸ tiktok | @thebenazadi https://www.tiktok.com/@thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
Hoy en Martha Debayle por W, hablamos de cuando se te rompe el corazón se le llama: Síndrome de TakoTsubo, cómo definir tu propósito en la vida, y ¿qué herramientas les estamos dando a nuestros hijos para cuando lleguen a ser adultos?
Viene Manlio Fabio Márquez a hablarnos sobre el Síndrome de TakoTsubo y cómo es que, literalmente, se te puede romper el corazón. ¿Cuántos de ustedes no han sentido que se les rompe el corazón cuando han tenido una decepción amorosa? Pues ¡es real! Hoy les explicamos qué es el síndrome de corazón roto o Síndrome de TakoTsubo.
ESC TV Today brings you concise analysis from the world's leading experts, so you can stay on top of what's happening in your field quickly. This episode covers: Cardiology This Week: A concise summary of recent studies Takotsubo Syndrome Arrhythmogenic Right Ventricular Cardiomyopathy Mythbusters – Red rice - an alternative to statins? Host: Rick Grobbee Guests: Kristina Haugaa and Thomas Luescher Want to watch that episode? Go to: https://esc365.escardio.org/event/1077 Disclaimer This programme is supported by Siemens Healthineers in the form of an educational grant. The scientific content and opinions expressed in the programme have not been influenced in any way by its sponsor. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC. Declarations of interests Stephan Achenbach, Rick Grobbee, Kristina Haugaa, Nicolle Kraenkel and Thomas Luescher have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, Alnylam, Amgen, AstraZeneca, Bayer, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, Lilly, Novartis, Pfizer, Sanofi, Servier, Tecnimede. Davide Capodanno has declared to have potential conflicts of interest to report: Sanofi, Daiichi Sankyo, Terumo, Medtronic, Chiesi. Emma Svennberg has declared to have potential conflicts of interest to report: institutional research grants from Bayer, Bristol-Myers, Squibb-Pfizer, Boehringer- Ingelheim, Johnson & Johnson, Merck Sharp & Dohme.
Commentary by Dr. Valentin Fuster
Many parents of estranged adult children know the pain of a broken heart. But for some, Broken Heart Syndrome becomes a medical crisis. Also known as Takotsubo Syndrome or stress cardiomyopathy, Broken Heart Syndrome mimics the experience of a heart attack. But rather than being caused by blocked arteries, it's caused by a stress-induced temporary abnormality that usually resolves itself. Still, Broken Heart Syndrome can lead to life-threatening complications. If you have chest pain or shortness of breath, or suspect you may be having heart problems, seek medical help immediately. This episode doesn't constitute or contain medical advice. Instead, Tina offers specific research-supported tips to help you try to reduce the risk of developing Broken Heart Syndrome and other stress-related health problems, over time. You can't end your adult child's estrangement at will. But you can make personal decisions every day that protect, rather than jeopardize, your health -- even during an unwanted and emotionally stressful estrangement. For concrete ideas on how to repair your parent-adult child relationship, read Tina's book, Reconnecting With Your Estranged Adult Child. Reconnection Club members can discuss this and every episode in the General Discussion forum inside the Reconnection Club. Not a member yet? Learn more and join. RESOURCES: Takotsubo syndrome Experiential avoidance Constructive Wallowing Why We Sleep by Matthew Walker
We look at stress (Takotsubo) cardiomyopathy in the setting of critical illness, with Dr. Vincent Sorrell. Dr. Sorrell is a cardiologist at the University of Kentucky, where he helped develop the Advanced Cardiovascular Imaging Program, and is current Acting Chief of both the Division of Cardiovascular Medicine and the Gill Heart and Vascular Institute. Find … Continue reading "Episode 59: Takotsubo cardiomyopathy with Vincent Sorrell"
It's more than just sad songs on the radio. Takotsubo cardiomyopathy, better known as Broken Heart Syndrome, is a very real condition that some people suffer from. Dr. Purdy discusses what can trigger this syndrome, and what you can do to protect your heart. Hosted on Acast. See acast.com/privacy for more information.
This week, please join author Trisha Singh as she discusses her article "Manganese-Enhanced Magnetic Resonance Imaging in Takotsubo Syndrome." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass for the journal and its editors. We're your co-hosts. I'm Dr. Carolyn Nam, Associate Editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor, director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Carolyn, very interesting feature discussion this week. Many times we hear in magnetic resonance imaging the use of gadolinium contrast. And remember, gadolinium is an extracellular agent. And when we apply it in the heart, we look for infarcts, or areas of the heart that are perhaps dead, or scarred over. This week's feature discusses manganese as a contrast agent and it is an intracellular contrast agent. And very interestingly, it identifies calcium handling, so it's a marker of viability. And these authors are going to apply manganese as well as gadolinium in trying to understand mechanisms behind Takotsubo cardiomyopathy. But before we get to that, how about we grab a cup of coffee and jump into some of the other articles in the issue? Dr. Carolyn Lam: Oh, I'd love to tell you about the other articles. But just have to first say, I loved your description of the feature paper. It's right up your alley and I can't wait to learn more. But my first paper today I want to talk about pulse field ablation. Now, what is that? Pulse field ablation, or PFA, is a unique and novel technique to treat atrial fibrillation. It has a unique safety profile largely related to its preferentially for myocardial tissue ablation. And thus, sparing the esophagus and thus, deemed to have a unique safety profile. Now, a pentaspline catheter was the first such PFA system studied for AF ablation. And in the initial trials the catheter was used for pulmonary vein isolation and left atrial posterior wall ablation. However, following its regulatory approval in Europe, in clinical practice, physicians have ablated both these locations and expanded lesions that could be in closer proximity to the coronary arteries. Now, this is an unstudied important issue since preclinical and maybe some clinical data have raised the potential for coronary arterial spasm. Hence, the investigators led by Dr. Vivek Reddy from Icahn School of Medicine at Mount Sinai and colleagues studied the vasal spastic potential of PFA lesion sets, both remote from and adjacent to coronary arteries. Dr. Greg Hundley: Wow, Carolyn, this is a really interesting question. So what did they find? Dr. Carolyn Lam: In this retrospective analysis of a series of 25 patients undergoing PFA for atrial fibrillation in whom coronary angiography was performed pre, during and post ablation, they found that during pulmonary vein isolation and left atrial posterior wall ablation, coronary spasm did not occur. However, cavotricuspid isthmus ablation provoked severe subtotal vasospasm in five out of five consecutive patients. And this was relieved by in coronary nitroglycerin. ST elevation was not observed. No patient had severe spasm if first pretreated with parenteral nitroglycerin, either intracoronary or intravenous. And so in summary, coronary vasospasm was not provoked during PFA at locations remote from the coronary arteries. But when the energy is delivered adjacent to a coronary artery, like in cavotricuspid isthmus ablation, PFA did provoke subclinical vasospasm. And the phenomenon was attenuated by nitroglycerine administered either post hoc to treat spasm or as prophylaxis. And this is discussed in accompanying editorial, I like it, “Coronary Vasospasm in PFA Primum Non Nocere” by Drs. Estes and Sundeep and Saba. Dr. Greg Hundley: Very nice Carolyn. Very important research in this area using that particular methodology. Well Carolyn, my next study comes to us again from preclinical science. And Carolyn, this study evaluated mechanisms responsible for pulmonary hypertension. So as background, pulmonary hypertension is associated with increased expression of VEGFA and it's receptor VEGFR-2. But whether and how activation of VEGFA signal participates in the pathogenesis of pulmonary hypertension, that's unclear. And so these authors led by Dr. Yangxin Chen from Sun Yat-Sen Memorial Hospital and Sun Yat-Sen University evaluated VEGFA, VEGFR-2 signal activation and VEGFR-2 Y949 dependent vascular leak in lung samples from patients with pulmonary hypertension as well as in mice exposed to hypoxia. Dr. Carolyn Lam: Another one of those excellent translational pieces, isn't it Greg? So what did they find? Dr. Greg Hundley: Right Carolyn. So these authors found that pulmonary hypertension led to excessive pulmonary vascular leak in both patients and hypoxic mice. And this was owing to over activated VEGFA and VEGFR-2 Y949 signaling axis. Abolishing VEGFR-2 Y949 signaling via a specific point mutation was sufficient to prevent pulmonary vascular permeability and inhibit macrophage infiltration and Rac1 activation in smooth muscle cells under hypoxia exposure. This, in turn, led to alleviation of pulmonary hypertension manifestations including muscularization of distal pulmonary arterials, elevation of right ventricular systolic pressure and right ventricular hypertrophy. And so Carolyn, in summary, these results suggest that VEGFA, VEGFR-2 Y949 dependent vascular permeability is an important determinant in the pathogenesis of pulmonary hypertension and might serve as an attractive therapeutic target pathway for this disease. Dr. Carolyn Lam: Aw, thanks Greg for explaining that so well. The next paper talks about transcatheter aortic valve replacement of TAVR, recognizing that it is a well established treatment now for high and intermediate risk patients with severe symptomatic aortic stenosis. However, the question asked here is what makes some, but not all patients improve their left ventricular ejection fraction following TAVR associated after load reduction? Now, hypothesizing that circulating microRNAs may play a role here, the authors led by corresponding authors, Dr. Hosen and Jansen from University of Bonn and their colleagues profiled the differential expression of microRNAs in circulating extracellular vesicles in patients after TAVR. And in particular, the novel role of circulating microRNA 1225p in cardiomyocytes. Dr. Greg Hundley: Oh wow. So Carolyn, important study. So what did they find? Dr. Carolyn Lam: Well, first aortic stenosis increases circulating microRNA 1225p, which correlated with a lack of improvement of the EF in patients after TAVR. Extracellular vesicles harbored microRNA 1225p and facilitated its startling into the cardiomyocytes. Vesicular shuttling of this particular microRNA was regulated by a direct interaction with a multifunctional RNA binding protein called heterogeneous nuclear ribonucleoprotein U in a sequence specific manner. Extracellular vesicles containing the specific microRNA post transcriptionally repressed BCL2 an anti-apoptotic gene, which is central to cell viability and apoptosis. So in summary, Greg, an increase in extracellular vesicle microRNA 1225p in patients with aortic stenosis represents a novel mechanism for the deterioration of cardiac function in patients following TAVR. And pharmacological manipulation of this axis may improve ejection fraction and cardiac function in patients with aortic stenosis by improving the viability of cardiomyocytes, which opens the door to a potential therapeutic approach in patients with limited EF improvement following TAVR. Dr. Greg Hundley: Oh Carolyn, beautiful, beautiful description of that wonderful preclinical science. Well, let's reach into the mail bag and see what else is in the issue. And first, there's a research letter by Professor van Raalte entitled “Kidney Hemodynamic Effects of Angiotensin Receptor Blockades Sodium Glucose Co-transporter 2 Inhibition Alone and in Their Combination: A Crossover Randomized Trial in People with Type 2 Diabetes.” And Carolyn, there's also an In Depth piece from Dr. Marx entitled “GLP1 Receptor Agonist for the Reduction of Atherosclerotic Cardiovascular Risk in Patients with Type 2 Diabetes.” Dr. Carolyn Lam: Very, very nice papers, those two. There's also an exchange of letters between Drs. Hou and Sedej regarding the article, “Fine Tuning Cardiac Insulin Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.” As well as a Perspective by Dr. Eagle, “Comments on the 2022 Aortic Guidelines: Seeking More Precision in Aortic Care.” Now, let's go onto the feature discussion of all things MRI, shall we? Dr. Greg Hundley: You bet. More on manganese. Welcome listeners to this very interesting feature discussion on December 13th. And we have with us Dr. Trisha Singh from the University of Edinburgh in Edinburgh, Scotland. Welcome, Trisha. This is a fascinating study incorporating manganese cardiovascular magnetic resonance to study some of the mechanistic underpinnings of hypokinesis left ventricular hypokinesis in patients with Takotsubo syndrome. So maybe just describe for us some of the background information that went into the preparation of your study, and what was the hypothesis that you wanted to address? Dr. Trisha Singh: Yes, of course. So we know with patients with Takotsubo syndrome, it predominantly affects middle aged women, patients present with a degree of left ventricular dysfunction, which is transient. And, unfortunately, it can be quite difficult to diagnose because it can phenotypically present very similar to an acute coronary syndrome. We know from previous studies that these patients do have ongoing symptoms despite normalization of their LV function. And actually their outcomes are not as benign as previously thought. In terms of manganese enhanced MRI imaging, we at Edinburgh University have imaged patients with other cardiac conditions such as hypertrophic cardiomyopathy, and dilated cardiomyopathy. And have established that it can be used as a surrogate marker of myocardial calcium uptake and handling. So we were very interested to see whether or not patients with acute Takotsubo syndrome have got a myocardial calcium dysfunction and more importantly whether or not this translates into long-term dysfunction and perhaps could explain their symptoms and worse prognosis in long-term. Dr. Greg Hundley: Trisha, manganese MRI. Now, we hear about gadolinium MRI, how is manganese different? You mentioned it's a nice marker for calcium handling. Is this widely used clinically? What kind of contrast does it provide? Dr. Trisha Singh: So manganese was actually one of the first contrast agents to be used with magnetic resonance imaging. It kind of came about in the 1970s and 1980s. And previous animal models have looked at how it is essentially an intracellular contrast agent. And what I mean by that is manganese is a calcium analog and therefore, in cells where they are viable and there's intact cell function, they will be taken up through a voltage gated calcium channels. So, for example, in the heart. So the theory is that manganese, when you've got normal viability, manganese is taken up into the myocardium via voltage gate calcium channels. And several studies have shown that if you then have disease myocardium, these tissues do not take up the manganese as normal tissue would. And the main difference between manganese and gadolinium is they are both paramagnetic, which is why they're helpful and useful in MRI. But gadolinium, as a compound, is too big and it cannot cross an intact cell membrane and therefore, gadolinium is more extracellular. And as, we know, accumulates in tissues where there is increased edema, or water content. So gadolinium, for all intents and purposes, is incredibly useful contrast agent, certainly what we use predominantly at the moment in clinical practice, but it is extracellular. So the theory behind manganese is that it is an intracellular contrast agent as opposed to gadolinium. And where gadolinium accumulates in disease tissue, manganese accumulates in viable tissue. So they behave almost kind of in contrast to each other. And currently, manganese is not used in clinical practice. I think the only clinical compound contrast agent utilizing manganese was mangafodipir, otherwise known as Teslascan, which I believe came off the market in 2012 and that was predominantly used for imaging liver metastasis. Dr. Greg Hundley: Well Trisha, thank you for clarifying for us the difference between manganese, the intracellular contrast agent, and gadolinium, the extracellular contrast agent, that's so widely used clinically. Well, with that description, can you describe for us now, your study population and your study design? Dr. Trisha Singh: Perfect. So the study population was we aimed to recruit 20 patients with acute Takotsubo syndrome. The diagnosis of Takotsubo syndrome was based on a clinical diagnosis, so all our patients underwent a baseline echocardiography and invasive coronary angiography. Now, for us, the coronary angiography was quite important because we wanted to ensure we ruled out anyone with an acute myocardial infarction, which can often be tricky in this cohort of patients. So after recruiting 20 patients during the acute phase of Takotsubo, they all underwent a baseline gadolinium enhanced MRI scan followed by a manganese enhanced MRI scan. And these were done at least 48 hours a part. And then about three months roughly after the acute index, they were all invited to participate in a second manganese enhanced MRI scan. Dr. Greg Hundley: Very good. So two exams separated longitudinally over time. What were your study results? Dr. Trisha Singh: Our results demonstrated that during the acute phase as one would expect, patients had a degree of left ventricular dysfunction. The majority of our patients had afibrillar Takotsubo, so had afibrillar ballooning with preservation of the basal segments. With this, we also noted that in the areas that were affected by Takotsubo, so kind of the mid ventricular wall and the apex that all patients had significantly elevated native T1 and associated T2 as well. And as we expected there was reduced uptake of manganese and therefore kind of reduced calcium uptake in the myocardium in the area affected by Takotsubo syndrome. Interesting, what we also noticed was that all these patients had significantly elevated LV mass, which has been described in previous Takotsubo papers, certainly by Professor Dawson. And when you measured the left ventricular wall thickness, the LV wall thickness is elevated in the affected and actually not even in the non-affected areas, which I suspect explains why in the acute phase people almost doubles up which kind I guess fit with kind of acute myocardial edema and intense water content. And then, three months later when these patients returned for their follow-up scan, a lot of the acute changes had resolved. So native T2 values had improved and gone back to baseline. Native T1 and post contrast T1 values had remained elevated compared to the control population. And what we found was that manganese uptake, though it had improved, it still remained abnormal and reduced compared to the control population, which is a finding that we weren't expecting to find. Dr. Greg Hundley: Very interesting. So acutely we've got extracellular water there, elevation of myocardial T2, and also impaired manganese uptake. So intracellular abnormalities with calcium handling. Then later, so three months later, we have restoration of myocardial T2 so the extra water content is absent, but we have impaired manganese uptake indicating an abnormality with calcium handling. So how do we put this all together mechanistically? What does this tell us about the pathophysiology of Takotsubo syndrome? Dr. Trisha Singh: For one thing, I think we can say that there is, as described before, there is obviously intense myocardial edema present in patients with acute Takotsubo. And I think the significant elevation in T2 and LV mass kind of all fits together. Actually interestingly, as native T2 improves in their follow-up scans, the LV mass actually all return back to normal baseline. So I think the acute edema does resolve. And as you said, interestingly, despite all of these patients, their LV function completely recover. And despite that their myocardial calcium uptake, or handling remain normal. And I think that's not been demonstrated before. And I think it just points to that there is obviously, still something going on in the myocardium and it's not behaving completely normally despite completely normal kind of gross LV function. And potentially, this might point in the direction of why these patients have ongoing symptoms. So, certainly, from our observational cohort group, about 70% of patients had ongoing symptoms and this was predominantly breathlessness and palpitations. And potentially, might be related to why patients have worse outcomes compared to the general population. Dr. Greg Hundley: Very nice. And Trisha, can you describe, was there a therapeutic intervention between the acute and then the three month later measurements? Were these patients administered any type of medical therapy and were there differences in what those therapies may have been between different patients in your study? Dr. Trisha Singh: So predominantly, most of the patient population that were started on some combination of heart treatment due to the baseline LV dysfunction. And this kind of was a combination of most of them were on Ramipril, a few of them were also on spironolactone or eplerenone. And then, every single one was on furosemide. And interestingly, I mean I appreciate, I think the population group was quite small, so it's very difficult to compare those that were on kind of full heart failure treatment versus those who were just on beta blocker and ramipril therapy. But even in that cohort there was a split of about, I think predominantly, I think 17, 16 patients were on kind just beta blockers and ramipril as opposed to beta blocker, ramipril, spironolactone. And there was no difference kind of in the recovery in manganese uptake in that cohort. But, again, the numbers are quite small, so I think it's difficult to extrapolate any kind of true meaning in that. Of course, we know there's a lack of randomized control trial data looking at how to best treat patients with acute Takotsubo syndrome and certainly, what treatment may prevent these patients from having a recurrence of Takotsubo. And I know some of the TACA registry data has looked at actually despite the fact patients of being on beta blocker, or ramipril therapy, they still go having recurrence of Takotsubo and certainly of our cohort, one of our patients went on having a recurrent episode of Takotsubo within a year of her index event and she was on aspirin, beta blocker, spironolactone as well. Dr. Greg Hundley: Very nice. And then lastly, when you made these measurements looking at the manganese uptake or lack thereof, were these in the regions of myocardium where you mentioned many had apical LV wall motion abnormalities, were they in those regions or did you also measure regions remote to where the wall motion abnormality occurred? Dr. Trisha Singh: Of course. So we took measurements in the affected regions of the heart that kind of demonstrated spironolactone syndrome. And we also took measurements in kind of, so to speak, the remote segments of the heart. Now, for the remote segments of the heart, we could only measure native T1 and post contrast T1 at 30 minutes and to measure manganese uptake well, unfortunately, what we have to do is take a measurement over time, so we'd do every two and a half minutes for 30 minutes after the manganese contrast. So we weren't able to calculate manganese uptake in the remote regions. But what we could do was measure the native T1 in the remote region, and then the post contrast T1 and see how it differed with the region of interest in the affected portion of the heart, so to speak. Dr. Greg Hundley: Very good. Well, Trisha, with this really exciting research and very nice methodology, what do you see as the next study to be performed in patients with Takotsubo? Dr. Trisha Singh: So I think, in terms of manganese enhanced imaging, I think it'd be really interesting to re-scan these patients at one year or at two years. And the question there is whether or not their manganese uptake ever recovers really. I know we previously talked about this and thought about whether or not these patients who go onto developing Takotsubo syndrome might actually have a kind of an underlying cardiomyopathy that puts them at risk of developing Takotsubo with stress. So it'd be interesting to see whether or not actually their calcium uptake ever recovers in the long-term, or whether actually they have more of a chronic heart failure type like picture. And I think another area of interest would be to see potentially using manganese imaging as a noninvasive measure of kind of myocardial calcium activity and to see whether or there's any changes with therapy over the course of months to years or so. Dr. Greg Hundley: Very nice. Well listeners, we want to thank Dr. Trisha Singh from University of Edinburgh in Edinburgh, Scotland for bringing us this really interesting article in patients with Takotsubo syndrome demonstrating that there is a marked perturbation of myocardial manganese uptake, which is most evident in the acute phase of Takotsubo presentation, but also persists for at least three months despite apparent restoration of normal left ventricular ejection fraction and resolution of myocardial edema. All of this suggesting that abnormal myocardial calcium handling may be implicated in the pathophysiology of Takotsubo syndrome. Well, on behalf of Carolyn and myself, we want to wish you a great week. And we will catch you next week on the run. This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ajjournals.org.
Après 32 ans de mariage, Claudine a appris que son mari fréquentait une autre femme. Pourtant, celui-ci ne voulait pas divorcer. La violence de la découvert a provoqué chez elle un syndrome du cœur brisé (Takotsubo) et une dépression. Elle tente de faire le maximum pour garder le moral mais Claudine a l'impression de stagner. Chaque soir, en direct, Caroline Dublanche accueille les auditeurs pour 2h30 d'échanges et de confidences. Pour participer, contactez l'émission au 09 69 39 10 11 (prix d'un appel local) ou sur parlonsnous@rtl.fr
In today's podcast we talk about stress related to grief. One of the greatest stresses that we experience as humans and that is the loss of a loved one. Loss, stress and grief can also be related to the end of a relationship for example because of a divorce or a breakup or even the end of a friendship. It could be related to the loss of a job, needing to move homes or the loss of a pet. The stages of grief are not necessarily linear; we can even go through all of them in a day. We may feel denial, being in shock, anger, guilt and fear. We may also experience depression and sadness. It's also important to allow ourselves to experience grief the way that it happens for each of us individually. I want to share with you more about the research related to how loss and grief create stress on our bodies. In a study from 2012 they found there is definitely a change in our cortisol and adrenaline levels when we experience loss.1 One of the areas that I have been researching for over 20 years is measuring cortisol and adrenaline levels in myself and my patients and understanding how we are all unique in terms of how our cortisol and adrenaline shifts when we're under stress. I find it very interesting that the studies on loss and death of a loved one showed that it's more common for cortisol and adrenaline to be elevated in the first two weeks to six months after the loss. A year after the loss, if people continue to have symptoms of grief, they are more likely to have low cortisol levels. It's really important to know how your body is responding because then we can do something about it and recover. We can start regulating our adrenaline and cortisol levels so this doesn't become a long term or permanent issue. We can work to reset the HPA Axis (hypothalamic pituitary adrenal axis) to tell our bodies to produce more or less cortisol and adrenaline and regulate our stress response. Studies also show that when a person experiences loss, it can increase the likelihood of experiencing anxiety and depression. Also, our immune system can be affected, and we can experience higher levels of inflammation in the body.2 Many other health problems can develop when under high stress, such as insomnia, heart attacks, strokes, cancer, increased susceptibility to viruses, such as HPV, and other infections. There is even a condition known as broken heart syndrome, or Takotsubo, when the heart muscle is weakened from grief and severe stress.3 When we're in a grieving process that has disrupted our neuroendocrine (nervous system and hormones) is when we need to have our cortisol and adrenaline levels measured. This is not done in the standard medical office so that's why I offer these tests through my office, so you can do them yourself at home. You can find these on the links below. Then you and I can meet, and I can help you understand your results and how to address them and use the right protocol of nutrients and herbs for you. https://doctordoni.com/product/assess-your-stress-type/ And this is not a one-size-fits-all treatment. Not everyone needs the same nutrients and herbs. It is crucial that we understand how our bodies respond to stress as an individual, and what doses and supplements are needed for our bodies to start healing. In my latest book “Master Your Stress, Reset Your Health” (https://doctordoni.com/master-your-stress/) I identified the correct sequence for helping you to get your cortisol, adrenaline and neurotransmitters back to optimal again, and it's based on what I refer to as your unique Stress Type. Once we know your Stress Type, we can help you to efficiently implement the nutrients and herbs that will help bring your levels back to optimal. - You can find which is your unique Stress Type by taking my Stress Quiz here: https://doctordoni.com/quiz I have also set up the stress type supplement bundles where you can get just the right supplements for your specific stress type. You can find these bundles in my store here: https://doctordoni.com/product-category/dr-doni-products/dr-doni-packages/ This is how passionate I am about helping you to recover from stress, including stress from loss of a loved one, so you can prevent the health issues associated with grief and so that you can be thriving in your life. If I can be of more assistance, please don't hesitate to reach out to me to set up a one-on-one appointment if you prefer: https://doctordoni.com/work-with-me/ You can also check out my most recent free masterclass: Transform Your Life: Get to the Root of Anxiety and Depression: https://doctordoni.com/transformanxiety/#blank-1 We're here to help you! - References: Buckley T, Sunari D, Marshall A, Bartrop R, McKinley S, Tofler G. Physiological correlates of bereavement and the impact of bereavement interventions. Dialogues Clin Neurosci. 2012 Jun;14(2):129-39. doi: 10.31887/DCNS.2012.14.2/tbuckley. PMID: 22754285; PMCID: PMC3384441. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384441/ Hopf, D, Eckstein, M, Aguilar-Raab, C, Warth, M, Ditzen, B. Neuroendocrine mechanisms of grief and bereavement: A systematic review and implications for future interventions. J Neuroendocrinol. 2020; 32:e12887. https://doi.org/10.1111/jne.12887 What is takotsubo cardiomyopathy? https://www.bhf.org.uk/informationsupport/conditions/cardiomyopathy/takotsubo-cardiomyopathy#:~:text=What%20is%20takotsubo%20cardiomyopathy%3F,extreme%20emotional%20or%20physical%20stress - Connect with Dr. Doni: Facebook HTTPS://FACEBOOK.COM/DRDONIWILSON Instagram HTTPS://INSTAGRAM.COM/DRDONIWILSON YouTube HTTPS://YOUTUBE.COM/USER/DONIWILSONND Weekly Wellness Wisdom Newsletter: HTTPS://DOCTORDONI.COM/WWW - Books and Resources: Order My New Book: https://www.amazon.com/Master-Your-Stress-Reset-Health/dp/1953295576 Stress Warrior Book (FREE) HTTPS://DOCTORDONI.COM/STRESSWARRIOR Stress Warrior Stress Resiliency Facebook Group (FREE) HTTPS://FACEBOOK.COM/GROUPS/STRESSWARRIOR 7-day Stress Reset (FREE) HTTPS://DOCTORDONI.COM/STRESS-RESET HPV & Cervical Dysplasia Guide (FREE) HTTPS://DOCTORDONI.COM/HPV-AND-CERVICAL-DYSPLASIA-GUIDE/ - Personalized Solutions: If you'd like to meet with Dr. Doni one-on-one for your health, request a Health Breakthrough Session: HTTPS://DOCTORDONI.COM/BREAKTHROUGH To get an idea of more comprehensive options, read about Dr. Doni's Signature Consultation Programs: HTTPS://DOCTORDONI.COM/SERVICES Disclosure: Some of the links in this post are product links and affiliate links and if you go through them to make a purchase I will earn a commission at no cost to you. Keep in mind that I link these companies and their products because of their quality and not because of the commission I receive from your purchases. The decision is yours, and whether or not you decide to buy something is completely up to you.
Our eyes are up here Geoffs! This week Spencer is answering the age old question, can you truly die of a broken heart? The answer might surprise you! Madison shakes things up with some of the most insane torture devices that ever existed. We've got a whole lotta obituaries this week and of course we've got some dumb.ass.criminalllllls! New episodes come out every Thursday for free, with 1-week early access for Wondery+ subscribers.Follow along online: @obitchuarypod on Twitter & Instagram. Write to us: obitpod@gmail.comSpencer Henry & Madison ReyesPO Box 18149 Long Beach, CA 90807Get a cameo from us: https://www.cameo.com/obitchuarypodcastSources:https://allthatsinteresting.com/rack-torturehttps://en.wikipedia.org/wiki/Riding_a_railhttps://www.ancient-origins.net/artifacts-other-artifacts/wooden-horse-0017081http://www.revolutionarywarjournal.com/riding-the-wooden-horse-other-medieval-tortures-adopted-by-washingtons-army-during-the-american-revolution/https://en.wikipedia.org/wiki/Poena_culleihttps://www.historydefined.net/pear-of-anguish/#:~:text=The%20Pear%20of%20Anguish%20was%20a%20medieval%20torture,centuries%20and%20caused%20immense%20suffering%20to%20its%20victimshttps://allthatsinteresting.com/scolds-bridlehttps://www.legacy.com/us/obituaries/augustachronicle/name/angela-obituary?id=16585082https://www.newspapers.com/clip/17156928/isaac-gravatt-finds-a-dead-man-who/https://www.legacy.com/ca/obituaries/timescolonist/name/george-adam-obituary?pid=201997771http://www.thesmokinggun.com/buster/disorderly-conduct/charles-easter-mug-shot-921670https://www.sporcle.com/games/g/stateshttps://en.wikipedia.org/wiki/Takotsubo_cardiomyopathyhttps://www.heart.org/en/search#q=takotsubo%20cardiomyopathy&sort=relevancyhttps://www.unitypoint.org/livewell/article.aspx?id=a7f06d29-de06-4343-bfef-ebb12fc667bdhttps://thoughtcatalog.com/daniel-hayes/2015/11/documented-cases-of-people-actually-dying-of-a-broken-heart/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Ever heard of "broken heart syndrome"?... it's a real thing. It's also called Takotsubo Cardiomyopathy or stress induced cardiomyopathy. In this episode we discuss a case of a patient who developed this unexpectedly, came very close to death, but made a full recovery. We break down the cause, presentation, and pathophysiology of Takotsubo Cardiomyopathy as well as treatment and prognosis.
I scheduled this podcast to come out on June 23rd and for all of you riding the TD right now, I hope this one inspires you. It amazes me to think that while I'm loosely shooting for a 3 week finish of the Tour Divide, in 2015, Josh Kato wrapped it up in just a hair over two weeks!! Don't let that discourage you, if you currently on route listening to this.Originally published on November 29th, 2020, this podcast dives into Josh's racing history, what the Riding the Divide means to him and also gets into what happened in 2019 that may have set his racing future on the back burner.————-I've been wanting to have a chat with this dude for a while now and we finally were able to connect. Those of you who are even mildly interested in the Tour Divide, a self supported race that takes riders 4,400 km down the continental divide and has them climbing the equivalent of Mt. Everest 7 times (nearly 61,000m), will know who this man is. In 2015, Josh Kato had the fastest time and finished this track in 14:11:37. Like other riders, he has returned again and again to challenge himself on this amazing route. While racing in 2019, a series of events occurred that would profoundly shake things up for Josh, forcing him to scratch. Takotsubo cardiomyopathy or stress-induced cardiomyopathy can strike even healthy individuals. In general terms, it is caused by extreme cardiovascular stress. Those who followed the race that year will remember how Sofiane Sehili and Josh were burning the track up. While a number of riders hunkered down at Brush Mountain Lodge due to very extreme weather, Josh was one the riders who persevered and pressed on. To say that he left everything out there would be an understatement. Josh grew up in the mountains in Washington and spends most of his time exploring with his wife Val and his superstar dog, Winston. As a nurse, he has been working the front lines of the Covid-19 pandemic and for that we owe him, and all the other medical professionals, our gratitude. It was such an honour to connect with Josh to get to know his story. He's a great story teller and there are some great tales from the trail in this conversation. If there is one thing I took away from this chat, as I get ready for my own crack at the Divide, It's to have fun! This goes for any of you too. Ride bikes, have fun and your journey will be a success no matter what the outcome. Oh, fun fact! I also learned that you can break your fibula and still ride 800 miles. What a bad ass!!Save 25% off a consultation at Cycling 101 when you use the code MB40 at checkout.Save 25% at Dynamic Cyclist when you use the promo code MB40 at checkout.Visit Rollingdale CycleThanks to Ottalaus Inc. for their support.Thanks to Spandex Panda for their support.Thanks to Lakeside Bikes in Invermere for supporting me!
Contributor: Peter Bakes, MD Educational Pearls: 3% of cases of acute coronary syndrome are due to Takotsubo Takotsubo cardiomyopathy or “broken heart syndrome” can occur with severe physiologic or emotional stressors, as these events can result in a profound outpouring of sympathetic neurotransmitters (epinephrine/norepinephrine) Receptors for these catecholamines are very dense around the apex of the heart, so the apical aspect of the heart can balloon outward as a result of this surge Most often cases resolve in several weeks although in rare cases it can lead to congestive heart failure or a thrombus formation References Ahmad SA, Brito D, Khalid N, et al. Takotsubo Cardiomyopathy. [Updated 2022 Jan 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430798/ Bossone E, Savarese G, Ferrara F, et al. Takotsubo cardiomyopathy: overview. Heart Fail Clin. 2013;9(2):249-x. doi:10.1016/j.hfc.2012.12.015 Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at https://emergencymedicalminute.org/cme-courses/ and create an account. Donate to EMM today!
This week on our nationally syndicated radio show, we learn how heartbreak can have physiological consequences on the heart and other organ systems. Broken Heart Syndrome, also called Takotsubo, is a form of stress cardiomyopathy. The effects of stress hormones due to an emotional blow or a serious illness can weaken the heart muscle. A […]
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