Podcasts about cytotoxin

Week-end de Paques, week-end metal ! Grace a ce nouvel épisode de L'Antre, vous serez au top pour récupérer les œufs, et en rythme ! Surtout qu'il est à noter que Skull Gwen est avec moi pour vous proposer sa rubrique, dans un tête à tête, plan à 3 avec vous, les gens ! Aprés bien sur qu'on vous balance infos, sorties et concerts avec un playlist juste parfaite : MOSH, ULTRA VOMIT, DIESECT, DIESECT, PSYKUP, GRAVE DIGGER, SHADOW OF INTENT, KHÔRA, TARJA, GRAVITY, UPON A BURNING BODY, TERAMAZE, THE YOUNG GODS, CYTOTOXIN, MAGNOLIA PARK, SUPREME VOID et EPICA !Du chocolat pour le bide et de la bonne musique pour tes oreilles !La playlist complète est là : https://drive.google.com/file/d/13r2gupaN2CiLtbXsJenxkYmLJKjT5FbV/view?usp=drive_linkAbonnez-vous à la chaine YouTube pour ne rien rater : https://www.youtube.com/@antremetal@Fatlab Studio @Skull strings @Asso We Rock @Actu-METAL Toulouse @Radio Transparence @Metal Invasion Radio/Podcast @poulettessisters #lesexplosdepit----------------------------------Easter weekend, metal weekend ! Thanks to this new episode of L'Antre, you'll be on top form when it comes to retrieving eggs, and in rhythm ! And it's worth noting that Skull Gwen is with me to bring you her chronicle, in a tête-à-tête, threesome with you, folks ! After that, of course, we'll be throwing news, releases and concerts at you with a playlist that's just perfect: MOSH, ULTRA VOMIT, DIESECT, DIESECT, PSYKUP, GRAVE DIGGER, SHADOW OF INTENT, KHÔRA, TARJA, GRAVITY, UPON A BURNING BODY, TERAMAZE, THE YOUNG GODS, CYTOTOXIN, MAGNOLIA PARK, SUPREME VOID and EPICA !Chocolate for your belly and good music for your ears !

Comme d'habitude, le programme est bien varié, puisqu'on va écouter des morceaux de sludge, de death, de thrash, de black,  mais aussi de blues rock et de horrorcore entre autres ! Notre groupe du mois est allemand : Cytotoxin. Bonne écoute !

Présentée par Jeff  Nouvelle salve de sorties avec cinq nouveautés pour une procession des plus versatile... PUTRID OFFAL explore la vie de Dominique-Jean Larrey, CYTOTOXIN revient sur les racines de la catastrophe nucléaire de Tchernobyl, IN THE WOODS... nous conte les légendes de l'Otra, KORSAKOV nous parle des pertes de mémoires et BLOOD ABSCISSION nous amène dans les abysses...  Concours Rituel Noir à 00:43:00

Well hello there! This week: Ascend the Helix, Barbarians of California, Blood Incantation, Better Lovers, Sol Invicto, Will Haven, Cytotoxin and Cult of Luna. PLUS an important apology…

Metal ist entgegen seiner Anmutung absolut nicht provinziell: Er ist nur die einzige Untergrund-Kultur, die genug Bodenhaftung besitzt um sich auch in jede Nische der Provinz vorzuwagen. Damit ist er eine oft unterschätzte "Brückenkultur", die sich mit einer eigenen Kritik-Kultur seit über 40 Jahren selbst frisch hält und dabei immer wieder den Spagat schafft zwischen Konservativismus und Progressivität. "Nadel verpflichtet" war zu diesem Thema mit einem Live-Panel beim Chemnitzer Demokratie-Festival "Kosmos" dabei, das am 8. Juni 2024 70.000 Menschen für ein offenes Miteinander im zentralen Schlossteich-Park der kommenden Kulturhauptstadt Europas versammelte. www.kosmos-chemnitz.de

See Video Here: Make Truth Known Again: https://GiveSendGo.com/BaalBustersDr. Ardis' Healing for the A.G.E.S. Stream tickets: https://na.eventscloud.com/ereg/newreg.php?eventid=759509 CODE: BB10DR ARDIS Membership: https://thedrardisshow.com/the-ardis-club-experience?aff=18DR MONZO CODE for 15% off: BaalBusters15. Click the Image at https://SemperFryLLC.comDr ARDIS Conference https://na.eventscloud.com/ereg/newreg.php?eventid=759509 Code: BB10Have you tired TRY BLUE? https://tryblue.refr.cc/baalbusters for 17% Off!Get Healthy with DR PETER GLIDDEN, ND https://riseupintohealth.com/?via=ndhealthGet an Advocate! https://graithcare.vitafyhealth.com/code/BBRESCUETHIS CHANNEL IS INDEPENDENT and has no sponsors but YOUPatreon: https://patreon.com/DisguisetheLimitsFUNDRAISER: https://GiveSendGo.com/BaalBusters Equipment List Itemized on GSGOR https://buymeacoffee.com/BaalBustersor JOIN Locals by Clicking the JOIN Button Beneath the video.RED PILL Expo Event and Livestream Tickets: https://redpilluniversity.org/expo-homepage/ref/179/ code: busterSHIRTS & MERCH https://my-store-c960b1.creator-spring.com/AWESOME Hot Sauce: https://SemperFryLLC.com Use Code at site for 11% Off qualified purchasesTwitter: https://twitter.com/DisguiseLimitsInstagram: https://www.instagram.com/baalbusters/Telegram: https://t.me/BaalBustersStudiosFREE Roku TV channel: https://channelstore.roku.com/details/a44cff88b32c2fcc7e090320c66c4d09/baal-busters-broadcast

Muito obrigado Bianca! Great video :-)DR ARDIS: https://theDrArdisShow.comCall-in: 619.354.8879 or On Telegram: https://t.me/BaalBustersStudiosHelp the Show Remain: https://GiveSendGo.com/BaalBustersor https://paypal.me/BaalBustersor https://tipeeestream.com/baal-busters/donation Thank You for the Much Needed Support!Get Healthy and Independent: https://riseupintohealth.com/?=ndhealthSubscribe to my Rumble Channel: https://rumble.com/c/c-1121444Subscribe on Brighteon: https://Brighteon.com/channels/BaalBustersFull Channel: https://BaalBuster.JoshWhoTV.comTelegram: https://t.me/BaalBustersStudiosTik Tok: https://www.tiktok.com/@baalbusters (shadow banned)Twitter: https://twitter.com/DisguiseLimitsFREE Roku TV channel: https://channelstore.roku.com/details/a44cff88b32c2fcc7e090320c66c4d09/baal-busters-broadcast New Years Resolution? Resolve to be Resolute in attaining your goals! Have lasting success the only way you can. By doing it naturally. Click the Link and Learn what the established medical profession does not know. "My people perish [suffer] for a lack of knowledge."https://riseupintohealth.com/?=ndhealthDr Glidden has 34 years of natural, root cause addressing expertise to share with you. Go there. Don't wait. Begin your new year by becoming a New You. I did it, and that's why, and only why I recommend it. It helped me profoundly.To help Ba'al Busters stay going and improve the equipment go here: https://GiveSendGo.com/BaalBusters It's always appreciated.For COPPERINE which my whole family uses, go here: https://BioChemScience.com and use BB2022 for Free ShippingLove Hot Sauce? Go Here! I make it: https://SemperFryLLC.comThe Host, Daniel Kristos, is a US Coast Guard veteran, author, a father, small business owner, researcher, avid reader, and independent historian.

We're celebrating the First Year Anniversary Program with the Best Ten Albums that We have played on ELEKTROSHOCK through these 365 days...Here you have the selected Bands by their position on our particular Ranking:10.- CYTOTOXIN - "NUKLEARTH"09.- KILLER BE KILLED - "RELUCTANT HERO"08.- BLEED FROM WITHIN - "FRACTURE"07.- LAMB OF GOD - "LAMB OF GOD"06.- AC/DC - "PWR UP""VERSUS" OF THE SEASON: CHILDREN OF BODOM - "TALK DIRTY TO ME"05.- ANGELUS APATRIDA - "ANGELUS APATRIDA"04.- CRYPTOSIS - "BIONIC SWARM"03.- HAKEN - "VIRUS"02.- VEXED - "CULLING CULTURE"01.- BENEDICTION - "SCRIPTURES"Closing Song: VOLBEAT - "THANKS"60 Minutes of Metal & More conducted by Marco A. Rondán.-

Does anyone smell radiation? That's probably because this episode we're joined by the nuclear brutal tech-death band 'Cytotoxin' and we cover everything from the influences behind their new album 'Nuklearth', crazy tour stories and some of the hardest challenges they've overcome as a band. WE DO NOT OWN ANY RIGHTS TO THE MUSIC USED. Listen to 'Nuklearth' and support Cytotoxin now: https://open.spotify.com/album/6Sa05ySGhMUYTO8HhI3lcS https://uniqueleaderrecords.bandcamp.com/album/nuklearth https://www.instagram.com/cytotoxin.official/?hl=en https://www.facebook.com/Cytotoxinmetal

End of the Year 2020, we bring to you Our Best Albums of this ending year!NAPALM DEATH - "THROES OF JOY IN THE JAWS OF DEFEATISM"TRIVIUM - "WHAT THE DEAD MEN SAY"BURY TOMORROW - "CANNIBAL"PERSUADER - "NECROMANCY"BENEDICTION - "SCRIPTURES"CYTOTOXIN - "NUKLEARTH"DEEDS OF FLESH - "NUCLEUS"AC/DC - "PWR UP"SONS OF APOLLO - "MMXX"

CYTOTOXIN ''NUKLEARTH'' Album Review(Track By Track) METALCAST LV #101 I am joined by Trez from Total Metal Rejection and Joe from the Nightmare Cabin youtube channel, Together we go through the latest full length album by tech death maniacs CYTOTOXIN titled ''NUKLEARTH''. This album came out on August 21st under the Unique Leader Records banner. (First attempt to do an album review podcast in English) Thanks for listening! NEVER FORGET

Animé par Eric & Jeff Le rendez-vous metal extrême de Radio Metal Pure Fuckin' Armageddon a proposé une interview avec Franck Peiffer de PUTRID OFFAL ce lundi 7 septembre 2020. Le groupe a sorti son nouvel album, intitulé Sicknesses Obsessions, le 11 septembre via Xenokorp. L'émission a proposé également une playlist musicale qui parcourre les dernières nouveautés de la scène black/death. Ce lundi soir était particulièrement axé death metal avec des titres des derniers albums de CYTOTOXIN, INGESTED, MERCYLESS, MORA PROKAZA et SEPULCHRAL CURSE.

SEPTEMBRIS 2020 Ikmēneša Metāla Šovs METĀLKĀSTS #95 Iespējams visnomācošākā epizode podkāsta vēsturē Šajā epizodē:

Opethian Transitions: Part Deux Unlike the last episode, this one doesn’t actually have anything to do with Opeth.  However, our transitions of styles from review-to-reviewContinue reading

'ONZWAAR, ONMETAAL', menig redacteur en fotograaf van Zware Metalen is wel eens geconfronteerd met deze leus tijdens het aanvragen van accreditatie voor optredens van bands die helemaal niet op Zware Metalen besproken zouden moeten worden. Green Day, Nickelback, Foo Fighters... gatekeepen is af en toe onvermijdbaar. Behalve dan in deze aflevering van Osmium - de zwaarste podcast in het Nederlands. Een bespreking van de death metal battle mondt uit in een discussie over de ruimte voor experimentatie in het metalgenre en niet-zware muziek die metalliefhebbers toch zouden kunnen waarderen. Uiteraard met muziek van Death. Onderwerpen: Death - Spirit Crusher (00:00) Introductie over verfsnuiven en het orakel van Delphi (00:17) Wederom een shout-out naar Kees, die eigenlijk Mike heet (01:14) De besproken onderwerpen van deze aflevering: death metal battle en niet-metal voor metalliefhebbers (02:25) Wees als Pim en laat een recensie van Osmium achter in iTunes (02:59) De verkiezing van de beste deathmetalbands volgens de lezers van Zware Metalen (04:28) Death metal uit de hoogtijdagen: vergane glorie en eentonigheid (08:28) Luistert de metalliefhebber tegenwoordig naar meer andere genres dan twintig jaar geleden? (13:10) Kunnen we de traditionele death metal doodverklaren? (14:54) Komt de hedendaagse innovatie binnen het metalgenre inderdaad van buitenaf? (18:40) De gitaar is verder verwijderd dan ooit, maar toch kruipt de metalen geest op andere manieren naar boven (26:01) Non-metal voor metalliefhebbers: Jaye Jayle - Prisyn. De elektronische kant van Nine Inch Nails gecombineerd met de onorthodoxe David Bowie en het doorleefde van Tom Waits en Nick Cave (28:01) Pim als Koning Wansmaak en Lowlands-ganger (38:08) Is elektronica de grootste blinde vlek van de metalluisteraar, en helpt Baroeg Open Air dat tegen te gaan? (40:10) Non-metal voor metalliefhebbers: Rival Consoles - Articulation. Ontroering, vernuft en onderdompeling binnen de minimalistische elektronica (49:12) Niels heeft het ineens over de soundtrack van Doom en Pim over Kanye West (58:29) Luistertip van Niels: Black Crown Initiate - Violent Portraits Of Doomed Escape, op het snijvlak van death en prog zonder de geur van rottende lijken (01:01:56) Luistertip van Pim: een deathmetaldrieluik van Katalepsy, Cytotoxin en Ingested op Unique Leader Records dat nostalgisch maakt naar het vervlogen Neurotic Deathfest (01:05:10) Shout-outs (01:09:22)

Heavy Pod Is Heavy Cast! This week we go back to our regular programming. New music/stuff/whatever from Ingested, Cytotoxin, Gojira, Defeated Sanity, In Flames, DVSR, John Petrucci, Let Us Prey, and Question. Also, Eden talks about some cross-talk with the Steel Legion Podcast. Then, cool people time with An American Pickle, Hellpoint, A Stranger in Olondria, the Death // Sentence podcast, and Blaseball. Enjoy!

En este nuevo episodio... JINJER, EPICA, ANTHRAX, KILL THE LIGHTS, STRYPER, ACE FREHLEY, CYTOTOXIN, RISING STEEL, NIGHTMARE y OMNIA TRANSIT. 3600 segundos de Descargas Metálicas Dirigidas y Presentadas por Marco A. Rondán.-

In this new episode...JINJER, EPICA, ANTHRAX, KILL THE LIGHTS, STRYPER, ACE FREHLEY, CYTOTOXIN, RISING STEEL, NIGHTMARE and OMNIA TRANSIT.3600 seconds of Metal Directed & Presented by Marco A. Rondán.-

Cytotoxin:https://www.facebook.com/pg/Cytotoxinmetalhttps://uniqueleaderrecords.bandcamp.com/album/nuklearthChiemseer:https://chiemseer-erleben.de/Microbrasserie Vox Populi:http://microbrasserievoxpopuli.com/Unique Leader IndieMerch Store:https://www.indiemerch.com/uniqueleaderThirsty Thursday Virtual Hang:https://us02web.zoom.us/j/81877361370?pwd=S1AxLzhCR21haDRFTXdsQnRrVzJRQT09Meeting ID: 818 7736 1370Password: VHSupport the Vox&Hops Podcast:https://voxandhops.bigcartel.com

Heavy Pod Is Heavy Cast! This week we talk about M. Shadows of Avenged Sevenfold making a statement about BLM, Clipping's new song on the matter, System of a Down being divided on the issue, and Fit for An Autopsy guitarist Pat doing his part. Also, some new and not so new music, in the form of Nevermore covers from Paladin, some techno-thrash in Lör and Vauxdvihl and Alarum, In Flames remastering and re-recording Clayman, and then new stuff from Protest the Hero, Cytotoxin and Unleash the Archers. Then, cool people stuff with Hannibal and The Last of Us Part II. Enjoy!

A conversation about being out on the amazing Hell Over Europe 2 tour (Aborted, Cryptopsy, Benighted & Cytotoxin), learning how to drink beer after rugby practice, the similarities between being on a rugby team & being in a death metal band, where he discovered his death metal voices, his job at home as a nurse at a hospital in the psychiatric ward and how to mourn past band members who had to leave Benighted for personal reasons. The beer which we drank during this interview was Azimut's American IPA. Which is a local craft beer brewery from Bordeaux, France. Matt's Beer of the week was Matera's S'toutünstout from Montreal Quebec! Benighted: https://benighted.bandcamp.com/ Azimut Brasserie: https://www.azimutbrasserie.com/ Matera Brasseurs: https://materabrasseurstonneliers.com/stoutnstout Julien Truchan's photo was taken by: Anthea Photography Concert https://www.facebook.com/AntheaPhotographyConcert/

A conversation about growing up in a small village in Germany, discovering guitar through progressive music, his transition to technical death metal once being asked to join Cytotoxin, the best metal bands on the rise, what it is like being a vegan on the road, band his dream tour lineup would include and what happens when the boys in Cytotoxin hear Extermination Dismemberment late at night on the tour bus. The beer that we drank during this episode was the classic Czech Pilsner: Pilsner Urquell. Cytotoxin: https://www.cytotoxin.de/ Pilsner Urquell: https://www.pilsnerurquell.com/

This week, Eden is gone! I swear this isn't some Fast and Furious 8 situation where Eden and I hate each other and don't appear on screen at the same time (see Vin Diesel and The Rock), but just real life getting in the way. But Tidal is still alive, so we must go on. This week we have Simon Handmaker, fellow Heavy Blog editor and meme master. We discuss some news/new music, like The Faceless facing troubles, Spotify needing to change their business model, and new music from: Myrkur, Contrarian, Wolves in the Throne Room, Celeste, Humanity's Last Breath, Cytotoxin, Rings of Saturn, Ne Obliviscaris, Tera Melos, Converge, Akercocke and August Burns Red. Then we do some cool people stuff talking about The Room and The Disaster Artist, some movies by A24 productions including The Lobster, then Pyre and PLAYERUNKNOWN'S BATTLEGROUNDS. Enjoy!

More than 50% of the world's population harbor Helicobacter pylori in their stomach mucosa. The chronic gastric infection is associated with several diseases including peptic ulcer disease and gastric carcinoma. One of the most thoroughly studied virulence factors produced by H. pylori is the Vacuolating Cytotoxin A (VacA). All isolated H. pylori strains possess the vacA gene, although significant sequence diversity was noticed in vacA genes across H. pylori isolates. VacA protein is produced and secreted as an 88 kD mature toxin. The protein binds to the host cells and is internalized. Inside the host cells, it causes “vacuole”-like membrane vesicles in the cytoplasm of gastric epithelial cells. Besides vacuolation, VacA exerts various other effects on target cells. VacA also forms membrane-embedded pores at the inner-mitochondrial membrane, resulting in mitochondrial dysfunction by cytochrome c release and apoptosis induction. VacA suppresses nuclear translocation of nuclear factor of activated T-cells (NFAT) resulting in down regulation of interleukin-2 (IL2) gene transcription to efficiently block proliferation of T-cells. The aim of this work was to understand the effects of VacA on intracellular calcium signalling in T-lymphocytes by considering the fact that VacA inhibits the Ca2+-calmodulin-dependent phosphatase calcineurin and induces cell cycle arrest. However, the exact mechanism how VacA exerts this response in T-cells is not known. Therefore, in this thesis various cell lines were used to study the effects of VacA on calcium influx. Calcium influx was found to be affected in the presence of VacA protein in the human Jurkat E6.1 T-cell line and primary human CD4+ T-cells activated by phorbol myristate acetate (PMA). Once inside T-cells, it could be shown that VacA suppresses the increase of the cytosolic free calcium concentration after stimulation by the calcium ionophore ionomycin and thapsigargin. Ionomycin forms pores in the cytoplasmic membrane, whereas thapsigargin blocks the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) and thereby causes depletion of the endoplasmic reticulum (ER) calcium store. In contrast, a VacA mutant, which was constructed by deletion of the hydrophobic region (amino acids 6-27), was unable to induce vacuolation activity and to block Ca2+ influx. A major result of this work was to demonstrate that one of the main components of store operated calcium entry (SOCE), the ER localized calcium sensor protein STIM1, is a target of VacA. Using co-localization studies and yeast two-hybrid (YTH) assays, it was found that VacA localizes to the lumen of the ER where it binds to the cEF-hand domain of STIM1. Furthermore, these data show that VacA strongly reduced the movements of the STIM1 towards the plasma membrane localized calcium channel ORAI1 after Ca2+ store depletion by thapsigargin. A YTH screen identified cEF-hand domain of STIM1 as the target of VacA to inhibit calcium influx. The results obtained in this work showing involvement of VacA in the modulation of intracellular calcium signalling will provide new insights that are required to understand how VacA inhibits T-cell proliferation and signalling.

Vincent and Elio discuss ancient symbiosis between Alphaproteobacteria and catenulid flatworms, and a toxin from Helicobacter pylori that engages the mitochondrial fission machinery to induce host cell death.

Infection with Helicobacter pylori, carrying a functional cag type IV secretion system (cag-T4SS) to inject the Cytotoxin associated antigen (CagA) into gastric cells, is associated with an increased risk for severe gastric diseases in humans. Here we studied the pathomechanism of H. pylori and the role of the cag-pathogenicity island (cag-PAI) for the induction of gastric ulcer and precancerous conditions over time (2-64 weeks) using the Mongolian gerbil model. Animals were challenged with H. pylori B128 (WT), or an isogenic B128DeltacagY mutant-strain that produces CagA, but is unable to translocate it into gastric cells. H. pylori colonization density was quantified in antrum and corpus mucosa separately. Paraffin sections were graded for inflammation and histological changes verified by immunohistochemistry. Physiological and inflammatory markers were quantitated by RIA and RT-PCR, respectively. An early cag-T4SS-dependent inflammation of the corpus mucosa (4-8 weeks) occurred only in WT-infected animals, resulting in a severe active and chronic gastritis with a significant increase of proinflammatory cytokines, mucous gland metaplasia, and atrophy of the parietal cells. At late time points only WT-infected animals developed hypochlorhydria and hypergastrinemia in parallel to gastric ulcers, gastritis cystica profunda, and focal dysplasia. The early cag-PAI-dependent immunological response triggers later physiological and histopathological alterations towards gastric malignancies.

Das humanpathogene Bakterium H. pylori persistiert im Gastroduodenaltrakt für Jahre oder sogar Jahrzehnte und löst durch die Kolonisation der Magenmukosa eine chronische Entzündungsreaktion aus. In den meisten Fällen bleibt diese symptomlos, es können jedoch auch schwerwiegende Erkrankungen wie ein Magen- oder Zwölffingerdarm-Geschwür oder Magenkrebs daraus hervorgehen. Obwohl die Infektion eine starke zelluläre und humorale Immunantwort hervorruft, kann H. pylori durch das Immunsystem nicht eliminiert werden. In dieser Arbeit wurde der Einfluss von H. pylori auf die Proliferation und Aktivierung von CD4+ T-Zellen untersucht. Dabei zeigte sich, dass H. pylori zwei Faktoren besitzt, um die Expansion der T-Zellen zu hemmen. Der eine, nicht näher charakterisierte Faktor scheint mit der Oberfläche der Bakterien assoziiert zu sein und inhibiert die Proliferation der T-Zellen bei direktem Kontakt der Bakterien mit den Zellen. Der zweite Faktor wurde als vakuolisierendes Zytotoxin VacA identifiziert, das, wie bisher bekannt war, in Epithelzellen die Bildung saurer Vakuolen auslöst. T-Zellen produzieren, wenn sie aktiviert werden, den Wachstumsfaktor IL- 2, beginnen sich zu vermehren und setzen eine Immunreaktion gegen das Pathogen in Gang. Das VacA-Toxin hemmt jedoch die Bildung von IL-2 und bewirkt eine Hemmung des Zellzyklus bei T-Zellen, indem es die Expression der Cycline D3 und E reprimiert. Diese sind essentiell für die Aktivierung des Retinoblastom-Proteins, das den Übergang des Zellzyklus von der G1- in die S-Phase vermittelt. Durch die Hemmung der IL-2-Produktion und die Erniedrigung der Oberflächenlokalisation von CD25, der -Kette des IL-2-Rezeptors, unterbricht VacA die Signaltransduktion, die normalerweise über den IL-2-Rezeptor zur Expression der Cycline führt. Die Hemmung der IL-2-Produktion durch VacA erfolgt auf transkriptioneller Ebene, indem die Aktivierung des Transkriptionsfaktors NFAT (Nuclear Factor of Activated T cells) verhindert wird. Die anderen für die Transkription des IL-2-Gens essentiellen Transkriptionsfaktoren AP-1 und NF-B werden durch VacA nicht beeinflusst. Die Stimulation der T-Zellen aktiviert zwei Haupt-Signalwege: einer führt über den MAPKinase / ERK-Kinase Weg zur Aktivierung von AP-1 und NF-B, der andere löst eine Erhöhung der Calcium-Konzentration im Zytoplasma aus, was die Ca2+-abhängige Phosphatase Calcineurin aktiviert. Calcineurin dephosphoryliert daraufhin den Transkriptionsfaktor NFAT und NFAT wird in den Zellkern transportiert, wo es zusammen mit AP-1 und NF-B die Transkription des IL-2-Gens initiiert. Es konnte gezeigt werden, dass VacA die Translokation von NFAT in den Kern durch Hemmung der Phosphatase-Aktivität von Calcineurin verhindert. Dies hat zur Folge, dass NFAT-abhängige Gene, wie das IL-2- Gen oder das für CD25 codierende Gen, nicht abgelesen werden können. Dass Calcineurin ein geeignetes Zielmolekül ist, um eine Immunantwort zu unterdrücken, zeigen auch die medizinisch bedeutsamen Substanzen FK506 (Tacrolimus) und Cyclosporin A. Beide V Zusammenfassung 91 Substanzen verursachen durch Hemmung von Calcineurin eine starke Immunsuppression. In DNA-Microarray-Analysen wurde untersucht, ob VacA einen ähnlich drastischen Effekt auf die Funktion der T-Zellen hat wie FK506. Dabei zeigte der Vergleich der Genexpression von VacA- und FK506-behandelten T-Zellen, dass VacA eine Untergruppe der Gene, die auch von FK506 reprimiert werden, herunterreguliert, wie z.B. die Gene für die Zytokine Macrophage Inflammatory Protein (MIP)-1, MIP-1, Single C Motif-1 (SCM-1) und SCM- 1. VacA scheint also die Genaktivität von T-Zellen ähnlich wie FK506 zu modulieren, was auf einen ähnlichen Mechanismus, nämlich die Calcineurin-Hemmung schließen lässt. Da das VacA-Toxin ein sekretiertes Protein ist, das auch in den tieferen Schichten des Magengewebes nachgewiesen werden kann, erreicht H. pylori nicht nur die vereinzelt im Magenepithel vorkommenden T-Zellen, sondern auch die T-Zellen, die bei der Infektion in die Lamina propria, eine tiefere Schicht der Magenmukosa, einwandern. Durch die Unterdrückung der T-Zell-Aktivierung und die Repression von Zytokin-Genen, die wichtig sind für die Modulation der Immunantwort, induziert H. pylori so vermutlich eine lokale Immunsuppression, die seine Eliminierung durch das Immunsystem verhindert und eine chronische Infektion des Magens ermöglicht. In einem zweiten Projekt wurde die Spaltung von CagA in ein 100 kD- und ein Tyrosinphosphoryliertes 40 kD- Fragment nach dessen Translokation in diverse Zelltypen untersucht. Dabei konnte gezeigt werden, dass die Prozessierung nicht nur in Makrophagen, sondern auch in dendritischen Zellen und in T-Zellen auftritt. Die Spaltung scheint von der Tyrosin-Phosphorylierung des CagA-Proteins und von Calcium abhängig zu sein. Dabei wurde die Ca2+-abhängige Protease Calpain in einem in vitro-Ansatz als ein CagAprozessierendes Enzym identifiziert. Auch in Makrophagen kann die Spaltung von CagA in P100 und P40P-Tyr durch den Calpain-Inhibitor Calpeptin verhindert werden. Die Tatsache, dass transloziertes CagA in allen getesteten eukaryontischen Zelltypen außer der Magenepithelzellinie AGS prozessiert wird, deutet darauf hin, dass diese Prozessierung eine biologische Bedeutung hat.

You wanted Metal? Heres your Metal! Hey welcome to a brand new month here at The Unsigned Countdown. We have got a great list of Unsigned and Independents that all bring the Metal. Founded as a Metal based Podcast back in the day, we have taken some time to explore the genres around the hard and heavy and have now returned to bleed your earballs once again. Each sonf hand picked by our staff here at Jarcodes and ranked by a growing team of experts from around the globe and from around the music community. Sit back relax and I dare you to not head bang the shit out of this. Thanks for listening. Feel free to like comment repost and share with your buds. Tweet your thoughts to us at Jarcodes on Twitter or even better follow the link under this track and help us grow our Facebook page. We are here for the bands and so you can show some support and love by letting us know which songs this month you liked. Follow the bands you enjoyed and lets get this shit going! #10 Hive Mind By Egregore From ??? Genre Metal  thrash metal  industrial metal Find Them On SoundCloud ReverbNation Song Link https://soundcloud.com/egregoreband/hive-mind Egregore Info Egregore is solo project of Houston progressive power metal band Descent Into Madness' main songwriter Alexander K. The purpose of this project is to expand into other musical territories, by adding some symphonic and industrial elements into the sound. "Hive Mind" features Jonathan Wilson www.reverbnation.com/musician/jonathanwilson on drums. Links SoundCloud https://soundcloud.com/egregoreband ReverbNation http://www.reverbnation.com/egregoreband #9 Trademark By Godzorder From Jundiahy Brazil Genre Thrash Metal Find Them On SoundCloud YoouTube Facebook Twitter Song Link http://youtu.be/hFi1SX6gCwQ Godzorder info Rafael Barba  Bass & vocals  Marco Mingote  Drums  Gustavo salles  Guitars   Andre Fernandes  Guitars band formed in 2013 by former members who figured in the underground scene of Jundiaí -SP / Brazil in the 1990s and 2000s . With influences of the greats of that time , his musical proposal features a more rhythmic heavy sound , with pinches of Hardcore and aggressive vocals sung in English. Links SoundCloud https://soundcloud.com/godzorder YouTube https://www.youtube.com/watch?v=hFi1SX6gCwQ Twitter https://twitter.com/Godzorderthrash Facebook https://www.facebook.com/godzorder #8 Inside The Other Side By Head Krusher From Taubaté São Paulo Brazil Genre Thrash Death Metal Find Them On SoundCloud Facebook YouTube Song Link https://www.youtube.com/watch?v=jr1hv62odOY Head Krusher Info Douglas Couto  Guitar Vocal  Darc Arantes  Guitar  Wellington Santana  Drums Lucas Almeida  Bass Links YouTube https://www.youtube.com/channel/UCFr-dUaQjCnrPQ-DPyy0fEw Facebook https://www.facebook.com/HeadKrusher SoundCloud https://soundcloud.com/head-krusher Metal Archive http://www.metal-archives.com/bands/Head_Krusher/63252# #7 Humanity Zombified By Nightmare Effect From Perth Australia Genre Heavy Metal Find Them On SoundCloud BandCamp Facebook Twitter YouTube MySpace Song Link https://soundcloud.com/nightmare_effect/humanity-zombified Nightmare Effect Info Matt Brennan-Jones  Vocals Sheldon Blackwell  Guitar Tom Rushen  Guitar John Louie  Bass Formed in early 2011, Nightmare Effect have sculptured a beast of a sound.  With a wide variety of influences ranging from beautiful melodies to eye bleeding rage; Nightmare Effect are like a schizophrenic, alcoholic, Angel...who likes to set things on fire. Links SoundCloud https://soundcloud.com/nightmare_effect BandCamp http://nightmareeffect.bandcamp.com/ Facebook https://www.facebook.com/NightmareEffect.au Twitter  https://twitter.com/nightmareffect YouTube https://www.youtube.com/user/NightmareEffectAU MySpace https://myspace.com/nightmare_effect #6 World Extinction By Extinctionist From Chemnitz  Dresden Germany Genre Death Metal  Find Them On SoundCloud ReverbNation Twitter Facebook Song Link https://soundcloud.com/extinctionist/extinctionist-01-world Extinctionist Info Vocals: Christian Bass: Jörg Guitar: Mitch Drums: Florian  someone who believes in the Philosophy that Earth would be far better off without People living on it, thus welcomes the Extermination of all Human Life on the Planet 2007 Founded as a one-man project by Guitarist Alexander Pohl (former PHILOSOPHER, CRYPTIC RITUAL), Extinctionist started with a clear musical approach: "No song slower than 220 bpm, no song longer than 2 minutes." Though that somewhat "Grindcore-Attitude" changed a little over time towards slightly longer (but not slower) songs, EXTINCTIONIST lost nothing on their Brutality and to-the-point precise killing approach. Soon completed by Sebastian "Grimo" Grihm on vocals, who contributes lyrics of post-apocalyptic damnation and human suffering, lurking in flocks in sewers under blown up chemical plants. Dennis Mitchell Petrausch on second Guitar and skilled drummer Christoph Weilbach joined in 2008 and EXTINCTIONIST became a deadly Live-Commando leaving nothing but devastated lands while playing venues throughout Germany. Their fanbase grows steady since then, their first release "All Flesh Must Be Eaten" was downloaded over 150.000 times and raised quite a buzz among Brutalheads and the Metal Press. In the year 2011 the full length album "World Extinction" was released and a few shows were played. In the year 2011 to 2012 there also was a changeover at the members Line-up. Grimo (now CYTOTOXIN), Christoph and Alex left the band in good. So new musician were needed.  Christian supports EXTINCTIONIST with his great vocals and Jörg will play the bass guitar, so the sound becomes much better and heavier. A drummer is still needed and we decide to use a drum-computer to fill in the missing part. In september 2013 EXTINCTIONIST became a part of the Label RISING NEMESIS RECORDS. In February 2014 the songs for the upcoming new album were recorded. In March 2014 Florian joined the band on drums and it's getting more and more brutal. During the whole year the band played a lot of Festivals and shows like Berlin Death Fest, Las Vegas Death Fest, Nice To Eat You Death Fest, etc. In November 2014 the 2nd full length album PORTALS OF EXTRATERRESTRIAL INVASIONS was released via Rising Nemesis Records. Links Soundcloud https://soundcloud.com/extinctionist Reverbnation http://www.reverbnation.com/extinctionist Twitter https://twitter.com/extinctionist Facebook https://www.facebook.com/extinctionist