Podcasts about wierenga

Listen to the founder of The Lulu Tree, Emily Wierenga being interviewed by seasoned journalist Lorna Dueck in this profound and inspiring episode of Scripture Untangled. Emily shares her harrowing, yet hope-giving story and talks about God's grace in her life, from her early exposure to living in Africa as a small child to moving back to Canada later and struggling with a life-threatening eating disorder that could have ended her life. Emily was impacted in a deeper way when she visited Africa as an adult and saw such a great need. Emily is an evangelist, sharing the Gospel where God leads. She is the author of God Who Became Bread and the founder of The Lulu Tree - a non-profit that serves vulnerable families in Africa and around the world. ---Learn more about the Canadian Bible Society: biblesociety.caHelp people hear God speak: biblesociety.ca/donateConnect with us on Instagram: @canadianbiblesocietyWhether you're well-versed in Scripture or just starting out on your journey, The Bible Course offers a superb overview of the world's best-selling book.  This eight-session course will help you grow in your understanding of the Bible. Watch the first session of The Bible Course and learn more at biblecourse.ca. ---Emily T. Wierenga is an award-winning writer and commissioned artist. Her memoirs include the newly-released God Who Became Bread, available on Amazon. Some of her other books include Atlas Girl, Making it Home, and Chasing Silhouettes: How to Help a Loved One Battling an Eating Disorder. Emily founded The Lulu Tree, a non-profit serving vulnerable families around the world. She lives with her husband and three children on a farm in northern Alberta, Canada. Learn more about Emily Wierenga: emilytwierenga.com

"May the light take over the dark. Some days it's hard. Some days the addictions seem to be winning. But we just keep on singing "Amazing Grace" and holding each other's hands and praying for the light to take over the dark.  And it always does."Leave a comment for Emily: https://incourage.me/?p=238740--In our book, 100 Days of Strength in Any Struggle, you'll discover where strength really comes from—Jesus, who holds everything together. Learn to find Him right in the middle of it, ready to strengthen you and give you rest. Order your copy today at incourage.me/podcast! The (in)courage podcast is brought to you by DaySpring. For over 50 years, DaySpring has created quality cards, books, and gifts that help you live your faith. Find out more at DaySpring.com.Connect with (in)courage: Facebook & Instagram for daily encouragement, videos, and more! Website for the (in)courage library, to meet our contributors, and to access the archives. Email us at incourage@dayspring.com. Leave a podcast review on Apple!

Jeshua Lauka is an attorney based in Grand Rapids, Michigan. Devoted to advancing effective biblical leadership, Jeshua shares profound insights into what it means to be a servant leader in all spheres of life. Beyond his professional journey, he opens up about his powerful personal testimony rooted in resilience and faith. Join us as we explore how God's work has shaped Jeshua's life and leadership principles, and how you can apply these lessons into your own contexts. Don't forget to subscribe to our new YouTube channel for more of such inspiring content. Resources mentioned on the show Jeshua's LinkedIn page Every Good Endeavor book Craig Groeschel Podcast John Maxwell booksFaith Driven EntrepreneurSupport the showBe sure to rate and follow our podcast!

Youtube https://youtu.be/iEaiVRgGwhY Facebook group https://www.facebook.com/vanja.wierenga I help mothers to become their child's best Natural Doctor, so their little ones radiate with health CEO at Natural Health Specialist and works at Owner and CEO at Centrum voor Klassieke Homeopathie

https://youtu.be/iEaiVRgGwhY Youtube Version Facebook group https://www.facebook.com/vanja.wierenga I help mothers to become their child's best Natural Doctor, so their little ones radiate with health CEO at Natural Health Specialist and works at Owner and CEO at Centrum voor Klassieke Homeopathie

Bekijk nu ook de nieuwe Borrelpraat Extra aflevering op Borrelpraat.com met daarin:Thijs wordt lijp in het verkeerComplete ruzie in de saunaNiels kreeg zomaar een scheet van een vreemde in het gezicht(Of luister de audio via Petje af)Probeer hier de handige app Riverty: https://riverty.app/nl-nl/open Zie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.

During our "True & Blue" interview, Huge spoke with Sgt. Tim Wierenga from the Kentwood Police Department. Tim filled us in on how recruitment has been throughout Michigan, told us about an awesome Drone Program they'll be implementing soon, and more.See omnystudio.com/listener for privacy information.

With the start of school upon us, we interview Certified College Financial Consultant Jeff Wierenga. Jeff discusses the ins and outs of how to save and invest for a child's education plus much more. You don't want to miss this informative conversation!

“We live in a gender-biased world, and that can kill”, says neuroscientist Lara Wierenga. There are even more exciting things we can learn from her podcast episode of “Kultur wandle Dich!”/”What the heck is going on?”. For example,  - what biases on gender differences are still out there, that are harmful, partly even deadly - how the brain differs between male and female (spoiler: yes, the male brain is 10% bigger, but...) - how hormone levels differ and what their effect is - what effect our chromosomes have (and whatnot!) - in what way social media is an exaggerator of stereotypes - the answer to a question I always had in winter: why women perceive the same outside temperature as colder than men

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.11.548438v1?rss=1 Authors: Peerboom, C. N. E., Wijne, T. B., Wierenga, C. J. Abstract: During the first two postnatal weeks intraneuronal chloride concentrations in rodents gradually decrease, causing a shift from depolarizing to hyperpolarizing {gamma}-aminobutyric acid (GABA) responses. GABAergic depolarization in the immature brain is crucial for the formation and maturation of excitatory synapses, but when GABAergic signaling becomes inhibitory it no longer promotes synapse formation. Here we examined the role of chloride transporters in developing postnatal hippocampal neurons using furosemide, an inhibitor of the chloride importer NKCC1 and chloride exporter KCC2 with reported anticonvulsant effects. We treated organotypic hippocampal cultures made from 6 to 7-day old mice with 200 M furosemide from DIV1 to DIV8. Using perforated patch clamp recordings we observed that the GABA reversal potential was depolarized after acute furosemide application, but after a week of furosemide treatment the GABA reversal potential but was more hyperpolarized compared to control. Expression levels of the chloride cotransporters were unaffected after one week furosemide treatment. This suggests that furosemide inhibited KCC2 acutely, while prolonged treatment resulted in (additional) inhibition of NKCC1, but we cannot exclude changes in HCO3-. We assessed the effects of accelerating the GABA shift by furosemide treatment on inhibitory synapses onto CA1 pyramidal cells. Directly after cessation of furosemide treatment at DIV9, inhibitory synapses were not affected. However at DIV21, two weeks after ending the treatment, we found that the frequency of inhibitory currents was increased, and VGAT puncta density in stratum Radiatum was increased. In addition, cell capacitance of CA1 pyramidal neurons was reduced in furosemide-treated slices at DIV21 in an activity-dependent manner. Our results suggest that furosemide indirectly promotes inhibitory transmission, but the underlying mechanism remains unresolved. The furosemide-induced increase in inhibitory transmission might constitute an additional mechanism via which furosemide reduces seizure susceptibility in the epileptic brain. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.24.536726v1?rss=1 Authors: Andrushko, J. W., Rinat, S., Kirby, E. D., Dahlby, J., Ekstrand, C., Boyd, L. A. Abstract: Past work has shown that there are both structural and functional differences in the brains of females versus males (Ritchie et al., 2018). Specifically, males have larger cortical and sub-cortical volume and surface area (both total and subregional), while females have greater cortical thickness in most brain regions. Given these differences it is possible that males may show larger volumes of brain activation and greater variability in patterns of brain activity. Yet to date little work has systematically considered whether patterns of brain activity indexed with functional MRI differ between females and males. The current study sought to remediate this issue by employing brain somatotopic motor mapping from a previously published (Ma et al., 2022) and openly available dataset to test differences in patterns of functional brain activity associated with 12 voluntary movement patterns in females versus males. We discovered that females exhibited smaller volumes of brain activation across all 12 movement tasks, and lower patterns of variability between female participants in 10 of the 12 movements. We also observed that in these data females had greater cortical thickness which is in alignment with previous structural sex difference analyses (Ritchie et al., 2018; Wierenga et al., 2022). Overall, these findings provide a basis for considering sex differences in future fMRI research and provide a foundation of understanding for which various neurological pathologies may present different between females and males. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

During our True & Blue segment, Huge was joined by Sgt. Tim Wierenga from the Kentwood Police Department. He joined Huge to talk about why he loves his job, filled us in on how you can get a job in law enforcement, and much more. See omnystudio.com/listener for privacy information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.13.528312v1?rss=1 Authors: Bijlsma, A., Vanderschuren, L. J. M. J., Wierenga, C. J. Abstract: Experience-dependent organization of neuronal connectivity is critical for brain development. We recently demonstrated the importance of social play behavior for the developmental fine-tuning of inhibitory synapses in the medial prefrontal cortex (mPFC) in rats. When these effects of play experience exactly occur and if this happens uniformly throughout the prefrontal cortex is currently unclear. Here we report important temporal and regional heterogeneity in the impact of social play on the development of excitatory and inhibitory neurotransmission in the mPFC and the orbitofrontal cortex (OFC). We recorded in layer 5 pyramidal neurons from juvenile (postnatal day (P)21), adolescent (P42) and adult (P85) rats after social play deprivation (SPD; between P21-P42). The development of these PFC subregions followed different trajectories. On P21, inhibitory and excitatory synaptic input was multiple times higher in the OFC than in the mPFC. SPD did not affect excitatory currents, but reduced inhibitory transmission in both mPFC and OFC. Intriguingly, the reduction occurred in the mPFC during SPD, while the reduction in the OFC only became manifested after SPD. These data reveal a complex interaction between social play experience and the specific developmental trajectories of prefrontal subregions. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.13.528278v1?rss=1 Authors: Peerboom, C., de Kater, S., Jonker, N., Rieter, M., Wijne, T., Wierenga, C. J. Abstract: During the first two postnatal weeks intraneuronal chloride concentrations in rodents gradually decrease, causing a shift from depolarizing to hyperpolarizing {gamma}-aminobutyric acid (GABA) responses. The postnatal GABA shift is delayed in rodent models for neurodevelopmental disorders and in human patients, but the impact of a delayed GABA shift on the developing brain remain obscure. Here we examine the direct and indirect consequences of a delayed postnatal GABA shift on network development in organotypic hippocampal cultures made from 6 to 7-day old mice by treating the cultures for one week with VU0463271, a specific inhibitor of the chloride exporter KCC2. We verified that VU treatment delayed the GABA shift and kept GABA signaling depolarizing until day in vitro (DIV) 9. We found that the structural and functional development of excitatory and inhibitory synapses at DIV9 was not affected after VU treatment. In line with previous studies, we observed that GABA signaling was already inhibitory in control and VU-treated postnatal slices. Surprisingly, fourteen days after the VU treatment had ended (DIV21), we observed an increased frequency of spontaneous inhibitory post-synaptic currents in CA1 pyramidal cells, while excitatory currents were not changed. Synapse numbers and release probability were unaffected. We found that dendrite-targeting interneurons in the stratum Radiatum had an elevated resting membrane potential, while pyramidal cells were less excitable compared to control slices. Our results show that depolarizing GABA signaling does not promote synapse formation after P7, and suggest that postnatal intracellular chloride levels indirectly affect membrane properties in a cell-specific manner. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Bertrie Wierenga bij Andy in de auto! Actrice, zangeres en model uit Friesland. Bekend geworden als Shanti van Goede tijden, slechte tijden. Veelzijdig talent, prachtige vrouw, veel humor en een fantastisch karakter. Mooi om deze Topper in de auto te hebben!

Master Sergeant Jan W. “Dutch” Wierenga is a little known but highly respected Special Forces and CIA legend. He has served the USA for sixty years in total, in some of the most dangerous and difficult circumstances imaginable. Born in Indonesia in 1936, he and his family spent a total of four years imprisoned in Japanese and Indonesian internment camps under unspeakably harsh conditions. They were rescued under fire by British Gurkha troops in 1946. He was running jungle combat patrols by age 16, and emigrated to Holland by cargo ship in 1955. He arrived in the USA in 1960, became a US citizen and enlisted in the US Army in 1963, serving three tours in Vietnam. A Green Beret, he was a Recon Team leader in the then-secret, now legendary MACV/SOG, running some of the most harrowing and highly-classified missions of the Vietnam War. He later served as a Special Forces Team Sergeant, Recon Instructor, HALO parachuting instructor and First Sergeant of the Special Forces Training School. He was the Senior NCO at the founding of the Survival Evasion Resistance and Escape (SERE) program under COL James “Nick” Rowe. Dutch earned numerous combat decorations including the Silver Star, four Bronze Stars and the Purple Heart. He retired from the Army in 1986.Dutch then joined the CIA as a Paramilitary Operations Officer. He conducted numerous clandestine missions for CIA, including serving as a Battalion Adviser to the Nicaraguan “Contras” and acting as Chief of Station in a war-torn African country. He became a beloved Training Instructor at the CIA's “Farm”, serving in that capacity until he finally retired in Spring 2022. Now, his incredible life story can at last be told. This book is the biography of this remarkable American patriot. It contains numerous period photos, and first-hand descriptions of Vietnam combat, CIA operations and other historic events. It was written by a friend and CIA colleague.Today's sponsors:

Mari Fong interviews Lindsey Stirling, singer-songwriter, violinist, and dancer, and Dr. Christina Wierenga, Professor of Psychiatry and Clinical Neuropsychologist at UC San Diego's Eating Disorders Center for Treatment and Research. Lindsey Stirling shares her story of anorexia nervosa and the depression and anxiety that came along with it. Lindsey's anorexia started in college and she takes us on her journey to recovery and maintenance of her condition. Currently on her 2021 Christmas Program tour, Lindsey recently dropped "Lose You Now" featuring Mako.  Next, mental health and eating disorders expert Dr. Wierenga shares new research on anorexia nervosa and the treatment steps that often takes a team of specialists to treat this serious condition.   “Be brave, ask for help, and be persistent in finding the mental help that you need.” For free and affordable solutions for mental health and addiction recovery, visit: http://checkyourheadpodcast.com/* Donate to our mission at checkyourheadpodcast.com or on our patreon.com page. Every dollar is appreciated, every listener is appreciated.THANK YOU for following us on social media @checkyourheadpodcastWatch and subscribe to our YouTube Channel:  checkyourheadpodcast.youtubeSupport the show (https://www.patreon.com/checkyourheadpodcast)

Inhibition is a fundamental function of the brain, our brain can't always be on. In this episode we talk with our guest, Dr Corette Wierenga, to better understand how our neurons can be activated in a way that starts to promote the growth of inhibitory connections. This is how our brains balance themselves, it is a method for the brain to work in real-time to alter the strength of different signals and ensure that no one signal gets too strong in the brain.

Today, the guys talk with Grand Rapids area actress Audrey Wierenga and they dive into the Tim Burton classic, The Nightmare Before Christmas. Do you think this movie is a Halloween movie or a Christmas movie? Let us know! You can find Audrey on her podcast, "And the Award Goes To..." wherever you listen to podcasts, as well as her blog, which can be found at audsblogs.com AS ALWAYS: Theme song and W.A.N.G theme created by Jair Driesenga. Follow him @brotherjair on Instagram, Facebook, Bandcamp, and Youtube. The logo for the pod was created by Grand Rapids area comedian Carl Sobel. Follow Brandon's comedy: TikTok/Twitter/Instagram: @brandonalberda Facebook: Brandon Alberda Comic Follow us on social media: Facebook: The Notes McGotes Podcast Instagram/Twitter: @NotesMcGotesPod Email: TheNotesMcGotesPodcast@gmail.com Our podcast is sponsored by: anchor.fm Leave us a voice message: https://anchor.fm/thenotesmcgotespodcast/message --- Send in a voice message: https://anchor.fm/thenotesmcgotespodcast/message

Red onion effective at killing cancer cells, study says University of Guelph (Ontario)  If you're looking for a flavorful way to help fight and prevent cancer, add red onion to your shopping list.  It will be worth the effort … as you will soon see why. In the first study of its kind, University of Guelph researchers looked at how the Ontario-grown red onion and several others affected the growth and proliferation of cancer cells. Their findings indicate that all onions are not created equal. The Canadian researchers looked at five different kinds of onion in total from the province of Ontario. They assessed the onions in terms of their effects against cancer cells and their ability to prevent cancer. Of the five species tested, the Ruby Ring red onion was the most effective. Few people are aware that onions are somewhat of a superfood. Hopefully, studies like these will help to change that. Onions in general have very high concentrations of the flavonoid quercetin. However, the Ruby Ring Ontario red onion has particularly high levels of these compounds as compared with other species. In the study, colon cancer cells were placed in direct contact with quercetin that was extracted from the five onion varieties studied. It was found that all of the onion types created an unfavorable environment for cancer cells and initiated cancer cell death, or apoptosis. Communication between the cancer cells seems to be disrupted by the compounds in the onions, and this can help to fight and prevent cancer. The study also showed that the Ruby Ring red onion was high in anthocyanin, a compound that helps to enrich the scavenging properties of quercetin. This in turn supports quercetin in fighting cancer cells and helping to prevent cancer. Anthocyanin is the molecule that gives vegetables like red onions their rich, deep color. This is in keeping with the general increased healthbenefits that can be gained from other dark or brightly colored vegetables and fruits. The recent onion study results were published in the journal Food Research International. While all of the onions studied showed the ability to inhibit cancer cells, red onions were particularly effective. Their beneficial compounds blocked the production of both colon cancer cells and breast cancer cells within the controlled conditions of the study. The next step is to complete human trials to further explore the cancer fighting effects of onions. Researchers are also working on an extraction technique to isolate the quercetin in onions so that it can be administered as a cancer therapy. In the meantime, finding ways to include more of this cancer-fighting superfood into your diet can allow you to experience many health benefits. Enjoy red onions in salads, on sandwiches and cooked into soups, stews and stir-fry dishes.     Age and aging have critical effects on the gut microbiome   Cedars-Sinai Medical Center, October 4, 2021 Researchers at Cedars-Sinai have found that aging produces significant changes in the microbiome of the human small intestine distinct from those caused by medications or illness burden. The findings have been published in the journal Cell Reports. "By teasing out the microbial changes that occur in the small bowel with age, medication use and diseases, we hope to identify unique components of the microbial community to target for therapeutics and interventions that could promote healthy aging," said Ruchi Mathur, MD, the study's principal investigator. Research exploring the gut microbiome, and its impact on health, has relied predominantly on fecal samples, which do not represent the entire gut, according to Mathur. In their study, investigators from Cedars-Sinai's Medically Associated Science and Technology (MAST) Program analyzed samples from the small intestine–which is over 20 feet in length and has the surface area of a tennis court–for examination of the microbiome and its relationship with aging. "This study is the first of its kind to examine the microbial composition of the small intestine of subjects 18 years of age to 80. We now know that certain microbial populations are influenced more by medications, while others are more affected by certain diseases. We have identified specific microbes that appear to be only influenced by the chronological age of the person," said Mathur, an endocrinologist and director of the Diabetes Outpatient Treatment & Education Center. The 21st century has been referred to as the "era of the gut microbiome" as scientists turn considerable attention to the role trillions of gut bacteria, fungi and viruses may play in human health and disease. The microbiome is the name given to the genes that live in these cells. Studies have suggested that disturbances in the constellations of the microbial universe may lead to critical illnesses, including gastroenterological diseases, diabetes, obesity, and some neurological disorders. While researchers know that microbial diversity in stool decreases with age, Cedars-Sinai investigators identified bacteria in the small bowel they refer to as "disruptors" that increase and could be troublesome. "Coliforms are normal residents of the intestine. We found that when these rod-shaped microbes become too abundant in the small bowel–as they do as we get older–they exert a negative influence on the rest of the microbial population. They are like weeds in a garden," said study co-author Gabriela Leite, Ph.D. Investigators also found that as people age, the bacteria in the small intestine change from microbes that prefer oxygen to those that can survive with less oxygen, something they hope to understand as the research continues. "Our goal is to identify and fingerprint the small intestinal microbial patterns of human health and disease. Given the important role the small bowel plays in absorption of nutrients, changes in the microbiome in this location of the gut may have a greater impact on human health, and warrants further study," said Mark Pimentel, MD, director of the MAST program and a co-author of the study. This research is part of Cedars-Sinai's ongoing REIMAGINE study: Revealing the Entire Intestinal Microbiota and its Associations with the Genetic, Immunologic, and Neuroendocrine Ecosystem.   Study finds no association between caffeine intake and invasive breast cancer risk University of Buffalo, September 28, 2021 Researchers from the University at Buffalo conducted a study of nearly 80,000 postmenopausal women in the U.S. to determine whether caffeine consumption from coffee and tea has any association with invasive breast cancer. The average age when U.S. women reach menopause, 51, also happens to coincide with the age group—50- to 64-year-olds—that has the highest reported caffeine consumption. In addition to that, the average age of breast cancer diagnosis in the U.S. is 62. This overlap of age at menopause, age at diagnosis of breast cancer and age with high caffeine consumption gave greater weight to the importance of clarifying whether caffeine intake impacts breast cancer risk in postmenopausal women. It does not, according to the UB researchers' findings, published in August in the International Journal of Cancer. "From our literature review, many studies have found significant associations between coffee and/or tea consumption and reduced breast cancer incidence whereas a few studies have reported elevated risk. Our study, however, found no association," said study first author Christina KH Zheng, who worked on the study while completing her master's in epidemiology at UB. She is now a surgical resident in the MedStar Baltimore general surgery program. "About 85% of Americans drink at least one caffeinated beverage a day. It is important for the public to know whether consumption of caffeinated beverages has beneficial or harmful effects on breast cancer, the most common type of cancer and second-leading cause of cancer death for U.S. women," said Lina Mu, MD, Ph.D., the study's senior author, who is an associate professor of epidemiology and environmental health at UB. "The overlap of age at diagnosis of breast cancer and age with high consumption of caffeine, and the inconsistent findings from previous studies motivated us to study whether this lifestyle factor could affect breast cancer risk in postmenopausal women," said Kexin Zhu, a study co-first author and epidemiology Ph.D. student in UB's School of Public Health and Health Professions. Researchers looked at a sample of 79,871 participants in the Women's Health Initiative Observational Study. Participants have for decades now completed yearly health questionnaires that help researchers learn more about diet and exercise habits, as well as disease, and any possible linkages. After a median follow-up of 16 years, there were 4,719 cases of invasive breast cancer identified. At first glance, women who reported drinking two to three cups of caffeinated coffee per day had a 12% higher risk of invasive breast cancer compared to non-drinkers. But that association was not statistically significant after adjusting for lifestyle factors, such as smoking and alcohol consumption. "Seeing null results after adjusting for lifestyle, demographic and reproductive factors informs us of the complexity that is the relationship between caffeine intake and invasive breast cancer risk," Zheng said. "Some lifestyle factors, like drinking alcohol and physical activity, might be associated with both coffee intake and breast cancer risk," Zhu explained. "Therefore, they might confound the initial positive associations. After we took the lifestyle factors into account, the results suggested that regular coffee drinking might not have an impact on invasive breast cancer risk." The risk of invasive breast cancer was even higher—22%—for women who reported drinking two to three cups of decaffeinated coffee each day. It was slightly lower when adjusted for lifestyle variables (smoking history, alcohol consumption, physical activity, etc.), and the association was not statistically significant when further accounting for reproductive variables such as family history of breast cancer and number of children The researchers were unable to determine if the elevated risk is due to the decaffeinated nature of the coffee, the amount consumed, or another factor unique to this population that was not accounted for in the study. The researchers did not observe a significant association between overall tea consumption and invasive breast cancer. Additional research needs to be done in order to understand whether different types of teas have different effects on breast cancer risk, Zhu said.   Liver function improves with the consumption of Broccoli sprout extract Tokai University Tokyo Hospital (Japan), October 5, 2021 A Japanese study of broccoli sprouts and liver function has found the sulforaphane-rich food to be highly beneficial. An extract from broccoli sprouts given to male participants was shown to improve hepatic abnormalities and overall liver function significantly. For the study, the researchers conducted a double blind, randomized placebo-controlled trial of males with fatty liver disease. The subjects received either extract of broccoli sprouts in capsule form, or a placebo. The capsules contained glucoraphanin, a precursor for the sulforaphane in broccoli sprouts. A number of key liver function markers were measured before and after the trial. It was determined that dietary supplementation with extract of broccoli improved liver functioning by decreasing alkali phosphatase activity and oxidative stress markers. Broccoli sprout extract was also found to prevent NDMA-induced chronic liver failure in rats. The researchers believe the antioxidants in broccoli sprouts are effective in suppressing the mechanisms of liver failure at a cellular level. The reduction of oxidative stress is crucial in protecting the liver and improving its health, and broccoli is loaded with health-supporting antioxidants. Non-alcoholic fatty liver disease (NAFLD) is also reaching epidemic proportions, with nearly 30 percent of Americans (90 million people) having some level of the disease. Like hep C, NAFLD can result in liver failure and cancer of the liver in the most severe cases. Exposure to environmental toxins exacerbates liver conditions as well, with the glyphosate found in weed killers, like Roundup, particularly harmful. The good news is that liver conditions are preventable by embracing a healthy lifestyle. Eating plenty of organic fruits and vegetables, exercising regularly and avoiding alcohol and cigarettes can do wonders for liver health. As evidenced by the recent research out of Japan, sulforaphane-rich broccoli sprouts can be a key component in supporting healthy liver function. Milk thistle, vitamin E, black seed oil and dandelion root have also shown effectiveness in supporting and detoxifying the liver.       How cannabis-like substances keep the brain in balance   Utrecht University (Netherlands), October 4, 2021 Whenever we learn, remember or forget something, a surprisingly active role is played by cannabis-like substances in the brain. Researchers at Utrecht University found that the substances actively balance connections in the brain that allow cells to either activate or inhibit each other. The discovery reveals how brain cells influence each other, and how psychiatric disorders can arise when this process goes wrong. Although wisdom comes with age, our brain does not store every single experience or lesson learned. In addition to learning and remembering, our brains are also equipped to forget irrelevant things or drop unused skills. In order to find a balance in this, brain cellsconstantly communicate with each other through connections that activate or inhibit the cells. Researchers from Utrecht University discovered that brain cells can form new, inhibitory connections via so-called endocannabinoids. They reported their discovery in Journal of Neuroscience. Counterbalance Endocannabinoids derive their name from the cannabis plant, which contains similar substances. The researchers discovered the role of endocannabinoids when they induced brain cells of mice to strengthen activating connections. In response, the brain cells also started making new inhibitory connections. The researchers found that endocannabinoids kickstarted the new connections. Surprisingly active role The researchers were surprised to find that these substances play such an active role. "Nobody expected this from endocannabinoids," says research leader Dr. Corette Wierenga, neurobiologist at Utrecht University. It was already known that endocannabinoids can influence the functioning of our brains. But until now researchers assumed that the substances were merely involved in adjusting existing connections. "Now it appears that the system of endocannabinoids can actively push the production of new inhibitory connections, with which brain cells actively regulate the balance." Psychiatric disorders caused by imbalance The discovery could help scientists to better understand how psychiatric disordersand other abnormalities in the brain develop. In many of these disorders, the balance between inhibitory and activating connections is disturbed. During an epileptic seizure, for example, this balance is seriously disturbed. Although in many other disorders the disturbance is more subtle, for example in schizophrenia, the impact can still be equally profound. Cannabis-related unbalance The balance between activating and inhibiting connections in our brain is constantly being adjusted in response to our experiences. Whenever we experience something, the connections change, and the brain must restore the balance. Cannabis use can disrupt that balance. "Occasional cannabis use will not seriously disturb the balance," says Wierenga. "But if the balance is disturbed for a longer period, it can cause problems. For example, children of mothers who smoked marijuana during pregnancy can experience problems with neurological development." Early stages of life The balance is especially important in early stages of life, Wierenga says. "During our development, brain connections are constantly changing. Especially during that period, it is important that inhibitory and activating connections remain coordinated. If the coordination is malfunctioning or disturbed, you can imagine that the system becomes disrupted. And unfortunately, disruptions that occur so early cannot be easily repaired later in life." According to Wierenga, such disruptions can lead not only to loss of memory, but also initiate more serious consequences. For example, the brain might grow out to less adaptive to stressful situations. "When this happens, things get out of hand more easily in the brain, because inhibition and activation are out of balance. That could lead to learning and behavioral problems." Predicting and preventing disorders Creating a deeper understanding of the role endocannabinoids play in the brain, could lead to psychiatric disorders being more predictable or even prevented in the future. The publication in Journal of Neuroscience now sets out a new direction in which more knowledge can be built up. Wierenga: "Ultimately, as a researcher, we want to understand how brain cells coordinate the balance and what happens when that balance is disturbed.   Glycerin is safe, effective in psoriasis model Medical College of Georgia at Augusta University, October 4, 2021 Patients with psoriasis have reported that glycerin, an inexpensive, harmless, slightly sweet liquid high on the list of ingredients in many skin lotions, is effective at combatting their psoriasis and now scientists have objective evidence to support their reports. They found that whether applied topically or ingested in drinking water, glycerin, or glycerol, helps calm the classic scaly, red, raised and itchy patches in their psoriasismodel, Dr. Wendy Bollag, cell physiologist and skin researcher at the Medical College of Georgia and Charlie Norwood VA Medical Center and her colleagues report in the International Journal of Molecular Sciences. The studies also provide more evidence of the different ways glycerin enables the healthy maturation of skin cells through four stages that result in a smooth, protective skin layer. Psoriasis is an immune-mediated problem that typically surfaces in young adults in which skin cells instead multiply rapidly, piling up into inflamed patches. "We have experimental data now to show what these patients with psoriasis are reporting," says Bollag, who nearly 20 years ago first reported in The Journal of Investigative Dermatology that glycerin, a natural alcohol and water attractor known to help the skin look better, also safely helped it function better by helping skin cells mature properly. Bollag's early report led to many anecdotal reports from individuals and their reports ultimately led to the newly published study. Topically, glycerin is known to have a soothing, emollient effect. But another key part of its magic, which Dr. Bollag has helped delineate, is its conversion to the lipid, or fat, phosphatidylglycerol, which ultimately regulates the function of keratinocytes, our major skin cell type, and suppresses inflammation in the skin. Glycerin gets into the skin through avenues like aquaporin-3, a channel expressed in skin cells, and the MCG scientists have shown that once inside, aquaporin 3 funnels glycerin to phospholipase-D-2, an enzyme that converts fats in the external cell membrane into cell signals, ultimately converting glycerin to phosphatidylglycerol. In 2018, Bollag and team reported that topical application of phosphatidylglycerol reduced inflammation and the characteristic raised skin patches in a mouse model of psoriasis. This time they decided to look at the impact of its widely available precursor glycerin. For the new studies, they used imiquimod, which is known to produce psoriasis-like plaques on humans using it for problems like genital warts and some skin cancers, to produce an animal model. The mice either drank the sweet natural alcohol or the scientists applied it topically. Either way, glycerin helped reduce development of the characteristic skin lesions, the scientists report, a finding which helps underline that glycerin works in more than one way to improve the skin condition. Externally, glycerin showed its action as an emollient because even in mice missing phospholipase-D-2, it was beneficial. Additionally, topically it appears to compete with hydrogen peroxide for space inside the aquaporin 3 channel. Hydrogen peroxide is commonly known as a mild antiseptic but we produce it as well and at low levels it's a cell signaling molecule. But at high levels, hydrogen peroxide produces destructive oxidative stress, which can actually cause psoriasis. The scientists found that topical glycerin reduced the levels of hydrogen peroxide entering skin cells. When they added glycerin and hydrogen peroxide at the same time directly to skin cells, they found that glycerin protected against the oxidative stress from hydrogen peroxide. "Glycerol is basically outcompeting the hydrogen peroxide in getting in there and preventing it from being able to enter and increase oxidative stress," Bollag says. Oil and water don't mix, so yet another way glycerin may be helpful is by supporting the skin's major role as a water permeability barrier so that, as an extreme, when we sit in a bathtub the bath water doesn't pass through our skin so we blow up like a balloon, she says. On the other hand, when glycerin was ingested by the mice missing the phospholipase- D-2, which converts fats or lipids in a cell's membrane to signals, it simply did not work, Bollag says, which confirmed their earlier findings that internally anyway, glycerin pairs with the enzyme to produce the signal essential to skin cell maturation. Some of their other most recent work is detailing more about how phosphatidylglycerol decreases inflammation.  Bollag would like next steps to also include clinical trials with dermatologists and patients and is working to find a formulation scientist who can make what she thinks will be the optimal combination: glycerin and phosphatidylglycerol in the same topical cream. The addition of phosphatidylglyerol itself, rather than just the glycerin that makes it, is essentially a backup since there is some evidence that in psoriasis the essential conversion of glycerin to phosphatidylglycerol is not optimal. Bollag's lab and others have shown reduced levels of aquaporin 3 in psoriasis, which likely means less phosphatidylgycerol, so making more glycerin available may help, albeit not as efficiently, raise the availability of this lipid essential to normal skin cell proliferation. Moving quickly into clinical trials should be comparatively easy since, as with glycerin, there already is experience with the use of phosphatidylglycerol in humans. For example, it's a component of some high-end cosmetics, Bollag says.  She suspects that this sort of two-punch combination, could help keep early signs of psoriasis at bay and, with more advanced disease, use existing psoriasis treatments to get the skin condition under control then start applying glycerin to help keep it that way. Bollag and her colleagues reported in 2018 in the Journal of Investigative Dermatology that in a mouse model of psoriasis, phosphtidylglycerol reduced inflammation and the characteristic raised skin lesions of psoriasis.  While its exact cause is unclear, psoriasis is an immune-mediated condition and patients have higher levels of inflammation, as well as too many skin cells being produced then maturing abnormally. The heightened inflammation also puts them at increased risk for problems like heart disease. Biologics used to treat psoriasis work different ways to stem this overactive immune response but in addition to their high cost, can put the patient at risk for problems like serious infections and cancer. The only side effect she has seen in about 20 years of working with glycerin and the clinical and cosmetic use already out there, is it can leave the skin feeling slightly sticky. Our bodies can make glycerol from the carbohydrates, proteins and fats that we eat or already have in our body.    

Today, we are joined by Corey's friend Audrey! She talks about the grief experienced when ending a best friendship. We dive deep into toxic people vs toxic situations, self-worth when grieving the end of a friendship and so much more. Follow Audrey: Instagram: https://www.instagram.com/auwie596/ Audrey's Blog: https://www.audsblogs.com Twitter: https://twitter.com/AuWie596 Audrey and Corey's Movie Podcast: https://open.spotify.com/show/442C3vsoiIWpTin1SOX0Qa   Follow Emotional Duct Tape at: Facebook: https://www.facebook.com/EmotionalDTPod/ Instagram: https://www.instagram.com/emotionalducttapepodcast/ Tikok: https://www.tiktok.com/@emotionalducttapepodcast Email us with questions or comments at emotionalducttape@gmail.com  

Join Justin and Andy this week as they're joined by Don for a trip down sugary memory lane. What do cookies, tarts, banana cake, and an Alaskan treat do to jog the old memory? **We're having a Live Meet-Up on August 14th from 4-7 PM EST at Buried Acorn in Syracuse, NY with Anthony of EatLocal NY. We can't wait to meet you!** Call our voicemail and leave us a message at: 315-313-5456 You can follow us on Instagram, Facebook, Reddit , and Patreon . Also, check out our YouTube page! Stop by our Sponsors at EatLocalNYState and check out all their content. Music: Funhouse by Crowander

Join Justin and Andy this week as they're joined by Don for a trip down sugary memory lane. What do cookies, tarts, banana cake, and an Alaskan treat do to jog the old memory? **We're having a Live Meet-Up on August 14th from 4-7 PM EST at Buried Acorn in Syracuse, NY with Anthony of EatLocal NY. We can't wait to meet you!** Call our voicemail and leave us a message at: 315-313-5456 You can follow us on Instagram, Facebook, Reddit , and Patreon . Also, check out our YouTube page! Stop by our Sponsors at EatLocalNYState and check out all their content. Music: Funhouse by Crowander License: https://creativecommons.org/licenses/by-nc/4.0/

Pete Wierenga was our guest on the podcast today - he talks about how running has supported him through many ups and downs in life (including a family tragedy early in his marriage). This is a photo of Pete and Sam's twins as children (Paige and Reece) - their son Reece passed away when he was 5 years old. The Dalai Lama suggests we cultivate peace in our minds and have a clarity of purpose - Pete tries to find this through running. A running tip from Pete - Get started and find a way that will make you accountable..  https://fitmindfitbody.co/podcast/

Adriaan Wierenga is noodrechtspecialist en houdt zich bezig met de juridische aspecten van openbare-ordehandhaving, rampenbestrijding en crisisbeheersing. Het zal niet verbazen dat hij een druk jaar achter de rug heeft, waarin de Coronacrisis zijn agenda bepaalde. In deze eerste aflevering van het tweede seizoen van Ons goed recht staan we nog eens uitgebreid stil bij de in de pandemie genomen maatregelen en hoe die zich verhouden tot grondrechten. Wat was ook alweer het probleem met de noodverordeningen en hoe heeft wetgeving dit kunnen oplossen? Welke afwegingen moeten in noodsituaties worden gemaakt en kunnen we grondrechten daarbij altijd beschermen? En kijkend naar de toekomt: hoe moet ons noodrecht worden aangepast om bij een eventuele volgende pandemie wel een sluitende basis te vormen?

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My guest is Louis Wierenga, a former US Marine who went to study in Canada befoire moving East. He is currently a junior Research Fellow at the Johan Skytte Institute of Political Studies of the University of Tartu, where he works on a PhD on the far right in contemporary Estonia and Latvia. You can follow him on Twitter at @louis_wierenga.Louis and I talk about far right politics in Estonia, in particular the Conservative People's Party of Estonia (EKRE), currently a member of the national coalition government, and its "alt-right" youth branch, Blue Awakening. We also discuss the link to the "alt-right" in the US.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.25.354423v1?rss=1 Authors: Myllykoski, M., Sutinen, A., Koski, M. K., Kallio, J. P., Raasakka, A., Myllyharju, J., Wierenga, R. K., Koivunen, P. Abstract: Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline residues. In addition to collagen P4Hs and hypoxia-inducible factor P4Hs, a poorly characterized endoplasmic reticulum (ER)-localized transmembrane prolyl 4-hydroxylase (P4H-TM) is found in animals. P4H-TM variants are associated with the familiar neurological HIDEA syndrome. Here, the 3D structure of the soluble human P4H-TM was solved using X-ray crystallography. The structure revealed an EF-domain with two Ca2+-binding motifs inserted to the catalytic domain. A substrate-binding cavity was formed between the EF-domain and the catalytic domain. The active site contained bound Fe2+ and N-oxalylglycine. Comparison to homologous structures complexed with peptide substrates showed that the substrate interacting residues and the lid structure that folds over the substrate are conserved in P4H-TM. Differences to homologs were found in the extensive loop structures that surround the substrate-binding cavity and generate a negative surface charge. Ca2+-binding affinity of P4H-TM was determined to be within the range of physiological Ca2+concentration in the ER. The proximity of the EF-domain to the active site suggests that Ca2+-binding is relevant to the catalytic activity. P4H-TM was found both as a monomer and a dimer in solution, but the monomer-dimer equilibrium was not regulated by Ca2+. The solved 3D structure suggests that the HIDEA variants cause loss of P4H-TM function. In conclusion, P4H-TM shares key structural elements with the known P4Hs while possessing a unique property among the 2-oxoglutarate-dependent dioxygenases having an EF-domain and a catalytic activity potentially regulated by Ca2+. Copy rights belong to original authors. Visit the link for more info

This week I talk with my friend Bre about ministry, calling, motherhood and her new book, The Jesus My Kids Taught Me. There are so many amazing nuggets of wisdom in this episode you don't want to miss! This episode is for everyone no matter what your current season is, I know you will be encouraged. Bre Wierenga is author of The Jesus My Kids Taught Me. Wife to husband Pat, mom of 5-year-old Sawyer and 2-year-old Poppy. Born and raised in Southern California until the family moved across the country to Cincinnati, Ohio just over a year ago. She's a speaker & preacher, a writer, and reader, a singer and wannabe dancer. She loves to laugh and make people laugh. Candy, gardening, and family are her favorite things. You'll find her at Queen City Church serving on Sundays and at home with the kids living that mom life every other day. A people enthusiast, a lover of Disneyland, baseball & jigsaw puzzles make up some of the little things in life that bring her joy. Connect with Bre: @brewierenga & @thejesusmykidstaughtme Buy her book on Amazon: https://www.amazon.com/dp/0578705435/ref=cm_sw_em_r_mt_dp_1yUkFbFWS5R83 --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

In this week's episode, Savannah Wierenga, MS, RDN, LDN, talks about all things diets! She covers diet culture, debunks common weight loss myths, and explains the science behind why diets are both dangerous and ineffective. Savannah also discusses Health at Every Size, Intuitive Eating, and BMI's place in this world. This episode has a wealth of information, and you won't want to miss it!! Resources mentioned in this episode: Intuitive Eating by Evelyn Tribole and Elyse Resch: https://read.macmillan.com/lp/intuitive-eating-4th-edition/ 10 Principles of Intuitive Eating: https://www.intuitiveeating.org/10-principles-of-intuitive-eating/ Diets Cause Weight Gain video: https://www.youtube.com/watch?v=udvXZY5awGM&t=72s Twin Study: Pietiläinen, K.H. et al. (2012). Does dieting make you fat? A twin study. International Journal of Obesity.36:456-464. Poodle Science: https://youtu.be/H89QQfXtc-k French Paradox: https://vimeo.com/198370073 Follow Savannah Wierenga: Instagram: the_savvy_dietitian work: https://ilivewellnutrition.com ___ About the podcast: The Life with Color podcast is dedicated to examining the intersection between eating disorders and different societies around the world. It serves as a means of education, connection, and a source of hope for those affected by eating disorders. The Life With Color Podcast will not only feature discussions with professionals on topics related to eating disorders, mental health, and nutrition— but it will also highlight stories of recovery from individuals from around the world. You can find the Life with Color podcast on Youtube, Spotify, and on any major podcasting platform. If you enjoy listening, please rate, review, subscribe, or share it with your friends! :) Follow the Life with Color podcast on: Katharinehn—— https://www.katharinehn.com/life-with-color-podcast YouTube—— https://www.youtube.com/channel/UClOjb9wBhnpQhWnD6MmVyog?view_as=subscriber Facebook—— https://www.facebook.com/LifewithColorpodcast Instagram—— https://www.instagram.com/lifewithcolorpodcast/ --- Support this podcast: https://podcasters.spotify.com/pod/show/lifewithcolorpodcast/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.01.070540v1?rss=1 Authors: Omrani, A., Bijlsma, A., Spoelder, M., Verharen, J. P. H., Bauer, L., Cornelis, C., van Dorland, R., Vanderschuren, L. J. M. J., Wierenga, C. J. Abstract: Experience-dependent organization of neuronal connectivity is a critical component of brain development, but how experience shapes prefrontal cortex (PFC) development is unknown. Here, we assessed how social play behaviour, which is highly abundant during post-weaning development, shapes PFC function and connectivity. We subjected juvenile rats to social play deprivation (SPD), followed by resocialization until adulthood. In a PFC-dependent probabilistic reversal learning task, SPD rats earned a similar number of rewards, but achieved more reversals than control rats. Computational trial-by-trial analysis showed that SPD rats displayed a simplified cognitive strategy. In addition, inhibitory synaptic currents were significantly reduced in layer 5 PFC cells of SPD rats, with specific changes in parvalbumin- and cannabinoid receptor 1-positive perisomatic inhibitory synapses. Thus, SPD has a long-lasting impact on PFC inhibition via synapse-specific alterations, associated with simplified cognitive strategies. We conclude that proper PFC development depends on pertinent social experience during a restricted time period. Copy rights belong to original authors. Visit the link for more info

We chat with documentary filmmaker Dirk Wierenga about his new film Route 2 Elsewhere. A documentary about the joys and challenges of living in rural America through the lens of a 1500 mile stretch of US-2 from the Upper Peninsula of Michigan to the plains near Shelby, Montana. It is an area of booms and busts from fur trapping to mineral extraction to lumbering to agriculture--which built and fed our nation.

Jeremy Wierenga is a second-year masters student in the International Political Economy and Development Program (IPED) at Fordham. He has worked with teachers and agricultural workers for three years in the Peace Corps in Panama and has been a farmworker advocate for four years in South Carolina. He believes that if we can become better connected to our food and where it comes from, we can build more equitable systems that ensure a sustainable path into the future. Rachel Ceruti is a yoga-loving second year IPED student specializing in sustainable banking and finance; in past lives, she has been a nanny, Peace Corps volunteer in Uganda, and special education teacher. Rachel is trying to figure out how to live a more sustainable lifestyle and is always happy to learn and share ideas. A few months ago she bought a metal straw and now thinks she is the queen of sustainable living. (Ask her about the time she declined an after party invite from a prominent DJ because the venue didn't recycle!) In this episode, we talk about Jeremy’s and Rachel’s unique interests in sustainablilty. We also delve into the many challenges faced by those trying to implement more sustainable daily practices such as composting or swapping clothes. Hope you enjoy!

I was fortunate enough to be joined by Kyle Wierenga who is the current CIO of Burton Snowboards. I am lucky to have known Kyle for several years now and his understanding of the Data Science/Advanced Analytics landscape within the Retail and Consumer Insight space is second to none.

Emily Wierenga is the founder of The Lulu Tree, a non-profit dedicated to supporting mothers and children in countries across Africa. In this episode, Emily shares the beginnings of The Lulu Tree and her eyewitness account of a miracle that occurred during an outreach event to expecting mothers.   The Lulu Tree 40 Day Sugar Fast with Wendy Speake

Veel hersenziektes zijn lange tijd beoordeeld als psychiatrisch, maar steeds meer wordt duidelijk dat er ook vaak gewoon een biologische verklaring voor is. Om daar meer over te kunnen zeggen, moeten onderzoekers eerst alles weten over de werking van al onze hersencellen. Zo zoomde onderzoeker Corette Wierenga in op de synapsen op hersencellen die verantwoordelijk zijn voor het doorsturen van signaaltjes. Ze ontdekte dat als ze de activerende synapsen op een hersencel sterker maakte, er zich automatisch remmende synapsen vormden. Ook ontdekte Wierenga en haar collega's dat er tijdens het vormen van zo'n remmende synaps, ook een stofje vrijkomt dat eerder al gelinkt werd aan autisme. Allemaal belangrijke informatie, voor als we uiteindelijk betere behandelingen willen vinden voor ziektes in de hersenen.

This week on The Sci-Files, Daniel and Chelsie interview Kathryn Wierenga. Kathryn is a doctoral student in the Biochemistry and Molecular Biology Department at Michigan State University. Her research focuses on an autoimmune disease known as lupus erythematosus.Autoimmune diseases affect over 25 million Americans. Her lab is studying how the development of lupus is affected by two environmental factors: silica, and the dietary omega-3 fatty acid (DHA). Kathryn's laboratory uses a lupus-prone mutated mouse model. She observes how intranasal exposure to silica triggers early loss of self-tolerance and onset of autoimmunity.If you're interested in talking about your MSU research on the radio or nominating a student, please email Chelsie and Danny at scifiles@impact89fm.org. Check The Sci-Files out on Twitter @SciFiles89FM and Facebook!

This episode is an interlude between the chapters of the City Within a City series. We will return to Chapter 3 in the next episode of the Antioch Podcast. Chapter 3 tells the story of how redlining affected people in Grand Rapids, Michigan. So before we tell this story, we will hear the stories of … Continue reading Episode 48: Jackson Beelen & Natalie Wierenga – “The City Within a City Interlude.”

In Adieu God? gaat Tijs van den Brink in gesprek met kerkverlaters. Zij zijn christelijk opgevoed en gingen vroeger naar de kerk. Wat is daarvan over? “Ik zou graag een ijzeren atheïst zijn, maar het zit er niet in.” Dat zegt Tommy Wieringa in deze aflevering van Adieu God? In zijn puberteit maakte de schrijver treinen kapot en leefde als een wolvenkind dat van God noch gebod wilde weten. Hij werd gered van de ondergang door een vrouw die zich opwierp als zijn pleegmoeder. Tommy Wieringa is naar eigen zeggen de meest gelovige ongelovige van Nederland. Want God mag wat hem betreft dan dood zijn, het christendom is dat niet. In het Nederlands Hervormde gezin waarin hij opgroeide, werd er weinig aan het geloof gedaan. Wieringa leerde pas bidden toen hij op een katholieke jongensschool terechtkwam. Thuis las zijn esoterisch aangelegde moeder, die er vandoor ging toen hij een jaar of elf was, hem voor uit de kinderbijbel. Die oerverhalen uit zijn kindertijd zijn terug te vinden in zijn romans. Wieringa leeft vanuit de gedachte dat de wereld bezield is en dat alle vormen van leven een samenhangend geheel vormen. Als kind zocht hij troost bij een boom, als volwassene kan hij zich opwinden over mensen die hun kamerplanten bij het grof vuil zetten. “Een trein kun je slopen, maar een ficus niet. Ik heb het idee dat dat leven verbonden is met het mijne.”

090317 Guest Preacher Josh Wierenga by revnorman

Erin Odom blogs at TheHumbledHomemaker.com. She’s wife to Will and Mommy to a lovely trio of redheaded girls and one sweet baby boy (yay! another boy mom!). Erin says she’s a recovering overwhelmed homemaker, and she writes about motherhood, homemaking, healthy living, and family finances. Her debut book, More than Just Making It: Hope for the Heart of the Financially Frustrated, is coming out on September 5th. I just have so much praise for her book! I’m so excited for Erin and delighted to have her as my guest today. Welcome to the show, Erin! Listen Now 2:10 - How a Low Point Turned into a Brilliant Book When Erin’s family was living the difficult story she recounts in her book, she would think to herself, “God is teaching me so much. What good will come from this? If I ever make it through this time, I want to do all I can to shatter the shame and stigma of the poor.”  But she never envisioned she would write a full book, and with a major publisher! Erin was raised in upper-class middle America, went to private school, and received a college education. Yet her book opens with Erin walking into the Department of Social Services to apply for food stamps. Like many of us would be, Erin was embarrassed and shocked to have found herself in that position. In fact, she says her pride was so strong that initially, she thought she would write an expose on government aid and how broken the system was! Erin’s story is one of being humbled over and over again. Her book formally began when an agent, actually through Facebook, reached out to her. Her agent told her three things were needed to publish a book: Be Able to Write Have A Platform Have a Story That Meets A Heartfelt Need Erin had several long phone conversations with her agent about her life, what she’d learned, and ideas she had, but things kept coming back to this low point in her life. While going through this time she would think, “We are just barely making it,” but at some point the tables began to turn and she started saying, “Okay, we can be more than just making it.” 6:45 - The Long Road to Publishing   Book writing can be more rigorous and drawn out than you might think! Erin signed with her agent in January 2014. She took two years to write book proposals due to other professional projects. Her book was finally written in 2016, and is now getting published in late 2017. Thanks to the time between the actual living through these events and the writing of her book, Erin had already processed much of the emotions bound up in her story. She had shared bits and pieces of the story to real life friends and blog readers, and already faced much of that shame and privilege in the eye. 8:15 - Expecting Critics Erin is also wisely looking ahead and anticipating critics. Especially due to the controversial nature of a few, main topics in her book - like government assistance - she knows there will be people who disagree. Erin says she’s at peace with that now, but also won’t be surprised if she sheds strong emotions when that first negative review comes! But even still, she says she couldn’t NOT have written her story. 11:30 - If You’re Thinking About Writing A Controversial Book (or Business) Especially for other Christians, Erin’s chief advice is to pray about the decision. Her book couldn’t have been written without lots of prayer! Also, she suggests doing a ton of research on your topic. Erin had her own story, but also she needed to research the facts to help her gain objectivity. 13:10 - Wisely Choosing What Influences Your Work Whatever book or business you want to produce, you’ll be influenced by what you read and listen to during the process. A couple of books in particular were foundational to Erin’s writing process during the proposal phase. She was very drawn to books which read like fiction, even if they weren’t! Bonnie Gray’s Finding Spiritual Whitespace was one such book on Erin’s list. Gray did offer practical tips on how to find whitespace, which was helpful to Erin in a time of entrepreneurial burnout, but her book was framed in memoir. Erin really loved that feeling! Emily T. Wierenga’s Atlas Girl, was another title that gripped Erin’s attention. Wierenga’s book didn’t have a practical element, but she does chronicle her time moving around the world, alongside the story of her mother having a terminal illness. Erin took this inspiration and thought, “if I want to write a book geared toward financial practicality, I don’t want it to be dry and boring.” She wanted her book to take her readers into the story. Erin wants people to feel that space with her, and evoke their empathy. “The way we evoke empathy for other people's stories is by sharing our stories.” 17:00 - The Hard Work of Book Writing Writing this book wasn’t easy, even having always loved writing and majoring in Journalism! Erin says she thought it would be much easier to write her book than it was. Around 2015 she was in entrepreneurial burnout mode, and simply longed to write. As her blog became a business, she got farther away from those writing roots and wanted to get back. Since this was her heart, she thought book writing would be easier....but it was MUCH harder! The memoir was emotionally difficult to write. There were many layers of her financial situation, and painful realities to walk through - some of those stories made it into the book and some didn’t. But writing the practical part? Well, Erin confesses that it was kind of boring to write! (We’re all business moms, aren’t we? We can admit there are boring parts to business, right!?) Primarily, Erin wondered if readers would even be helped by her tips! She didn’t want to write a book that only gave people the warm fuzzies, she wanted to write a book that gave steps to life change. (Phew! Erin placed a tall order on herself with this book… but I think she totally delivered!) 18:50 - What If This Is Super Obvious? It’s tempting to think that everyone already knows the things we do. When Erin was writing the book, she incorporated many tips her parents instilled in her. Both Erin’s parents grew up in large families with not a lot of extras; and though her own father had a great job, frugal living was the norm. She realized in the moment that God prepared her for her lean years since she was a girl. And Erin realized while writing the book that not everyone grew up in a family that was super frugal like hers was. (What’s common sense to us is often knowledge that others need to learn about!) 22:10 - Hope for the Frustrated If Erin could tell a mom feeling financially frustrated just one thing it would be, “There is always hope.” Of course, she can’t predict levels of financial success, but she can say, “Wherever you are doesn’t mean you’ll be there the rest of your life.” In any trial, it’s easy to think the trial will go on in the same way forever. Erin says, “Especially if you are listening to Brilliant Business Moms and you’re an entrepreneur, trying to make a business for your family, you’ve already taken a big step!” One major issue the Odoms discovered is that they had an income problem. A key component of her book is to identify that if you’re financially frustrated, you may have either an income problem or a spending problem. Once you know the root cause, you can find a solution. “If you have a small biz or are planning on starting one, you are steps beyond what many are,” Erin says. 25:05 - Making a Blog a Business The Humbled Homemaker (Erin’s successful blog) launched in 2011 and it was on a bit of a whim. She was freelancing for newspapers, and one of her editors told her, “Erin, there are moms making an income from home with their blogs.” The idea was certainly intriguing to her! At first, Erin had absolutely no money to invest into a business. There are lots of ways to start a blog or business by investing money up front, and you usually do get quicker returns. But Erin didn’t even have $10.00 for a website domain. Her first domain literally was thehumbledhomemaker.blogspot.com. Back then, as is true now, you couldn’t monetize a wordpress.com site but you could monetize blogspot.com domains. Erin’s blog was completely DIY’ed. Though one crucial step was Erin getting into a mastermind group from the beginning. The group provided her tons of resources, one of which included a friend who was eager to design her site! It was about 2 years before Erin was making more money online than her husband made as a teacher, and it was 3 before she was making a very good income from her blog. Erin and her husband Will thought a LOT about whether or not  he should quit his job. In 2014, he went down to teaching 4 days a week, and in December 2016, he totally quit his job as a teacher One reason her husband didn’t make the leap to quit his job was because they weren’t sure if their marriage would survive working together!! It’s a joke, but with a bit of truth to it! The first 6 weeks of working together in early 2017 went really well...and then their 4th baby was born! As with most newborns, a family adjustment was required. But 8 months in, Erin says it’s gotten better as time has gone on. Blogging as a business isn’t easy, and comes with lots of work. (Pssst. Another venture Erin had a big hand in was starting the Ultimate Homemaking Bundle with Stephanie Langford!) With all of these activities spinning at once, when Erin’s agent signed her, she was in a stage of burnout. But thankfully her agent did not pressure her to write a book proposal right away. (And it is highly unusual for an agent to not put pressure on writing a book proposal!) 29:50 - Book Marketing Some authors will receive a launch budget from their publisher, but not most! You have to do a LOT of marketing yourself, even with a traditional publisher. Erin did receive a marketing budget but is still pouring a lot of her own time and money into the book. One benefit of a traditional publisher Erin enjoyed is that she didn’t have to hire an editor or designer for her book. The quality of those services was very high caliber. Receiving a marketing budget depends largely on the publisher and the size of the author’s platform. But even with a marketing budget, Erin says that a publisher would not cover 100% of those expenses. The publisher may have a plan in mind, but the author will lead the way. In fact, some of Erin’s marketing ideas were covered by the publisher, while others were not. 32:44 - Why Traditionally Published? It’s possible to make more money by self-publishing if you know how to market well, so why traditionally publish? Erin says working with people has made it really worthwhile! She loves the accountability, and it fits her personality well to work with a publisher. That’s not to say she would never self-publish another book, but she’s really enjoyed this experience! 33:20 - Book Payments Let’s talk about the book money, honey! It is traditional to get paid part of the book’s advance before even writing the book! Erin’s publisher pays the advance in thirds. She got one third when she signed the book deal, the second 3rd upon getting the completed manuscript, and the final third when the book is published. Other publishers offer 50% upfront, and 50% when book gets published. Erin’s blog has taken somewhat of a backseat to the book, and so having that advance money is a really nice cushion as the blog is her family’s primary source of income! 35:40 Mark your Calendars for Erin’s Next Book! Erin already has her 2nd book on contract! It is a gift book that will come out in 2018. (And, yes, Erin wrote 2 books and had a baby in a twelve-month period, which she tells us isn’t necessarily recommended!) The upcoming book is a gift book, and it’s called ‘You Can Stay Home with Your Kids: 100 Tips, Tricks, and Ways to Make it Work on a Budget’. Actually a team at her publishing house came up with the concept and title, and asked her if she would write it! Erin was amazed that books go up on Amazon while they’re being written! (Like the book Erin is still writing which will come out in 2018.) Why the early-bird treatment? In the book world, preorders are everything. I just loved sitting down with Erin and chatting about her story, her incredible book, and her business wisdom. I hope you’ll go grab your copy of More than Just Making It, because I know you’ll find it incredibly encouraging and chock full of practical advice! 37:40 - Adorable Mom Moment You’ll have to tune in to the podcast to hear all about the sweet moments that are happening between Erin’s girls and their new little brother. So much cuteness! Stay in Touch With Erin! Erin’s New Book: More Than Just Making It Erin’s Blog: The Humbled Homemaker Facebook: The Humbled Homemaker Instagram: @thehumbledhomemaker

20-11-2016

Pianist Red Wierenga is a member of the Respect Sextet and the Respect Trio. He also plays accordion in the Claudia Quintet. In this interview, he talks about three new recordings: Respect 'n' You: Live At Greenwich House Music School by the Respect Sextet; Respect The Trio, We Says by the Respect Trio; and Figure, a duo project between Wierenga and guitarist Ryan Ferreira. He also talks about his forays into electronic music and instrument building; his work with the Claudia Quintet; and the influence on his music of Dutch pianist Misha Mengelberg. Learn more at respectsextet.bandcamp.com.

Pianist Red Wierenga is a member of the Respect Sextet and the Respect Trio. He also plays accordion in the Claudia Quintet. In this interview, he talks about three new recordings: Respect 'n' You: Live At Greenwich House Music School by the Respect Sextet; Respect The Trio, We Says by the Respect Trio; and Figure, a duo project between Wierenga and guitarist Ryan Ferreira. He also talks about his forays into electronic music and instrument building; his work with the Claudia Quintet; and the influence on his music of Dutch pianist Misha Mengelberg. Learn more at respectsextet.bandcamp.com.

Pianist Red Wierenga is a member of the Respect Sextet and the Respect Trio. He also plays accordion in the Claudia Quintet. In this interview, he talks about three new recordings: Respect ‘n’ You: Live At Greenwich House Music School by the Respect Sextet; Respect The Trio, We Says by the Respect Trio; and Figure, … Continue reading "The Jazz Session #453: Red Wierenga"

"Don't give up on the girl inside." I can't stop thinking about this simple phrase Emily said in our conversation about her story and her book Atlas Girl. As moms, the voice of the girl inside can get drowned out by all the expectation, comparison and busyness of life. Sometimes we can forget who we are, what we dream and the story that made us who we are. In this simple conversation, Emily shares her story of how cancer, an eating disorder and ultimately God have shaped her heart and her motherhood. Grab a cup of tea and join us on the couch for a conversation that will inspire and challenge you. In This Episode You'll Hear... About her journey around the globe as she searches and learns about the love of God What it has been like to experience an eating disorder as a young adolescent and a young mom What it looks like to pursue your dreams as a mom Solve The Dinner Dilemma A huge thanks to this month's Podcast sponsor Plan to Eat.Be sure to check them out and grab their FREE 30 day trial. Here are a few highlights from my meal plan this week. (Please remember I am not a gourmet chef. I am a "get out of there" chef. I like simple, fast and relatively healthy recipes. The Pioneer Woman...I am not. :) Spinach Feta Mushroom Pizza - this is SO good.Baked Spaghetti - simple, fast and the kids love it.French Toast - Mmmmm....Oatmeal with Cinnamon Apples and Toasted Pecans - is there anything better on a chilly morning? Click here to visit Plan To Eat and sign up for their free trial.Click the play button in the post or grab your favorite podcast app and join us for a chat! Tweet to Inspire: "Our job is not to fix the world but to love the world." Quick Links Atlas Girl at Amazon, Barnes and Nobles and Lifeway Psalm 139:14 Zephaniah 3:17 Love the song in the outro? It's called God Day. It's by Jen Stanbro and you can get it on iTunes by clicking here and check out Jen's site by clicking here. Connect with Emily Blog:Emily Wierenga Social media: Twitter Facebook Pinterest Instagram How to Listen to This Podcast Subscribe to the podcast in iTunes or Stitcher and get the latest episodes as soon as they are available. If you're new to podcasts, click here learn more about them!

“Don’t give up on the girl inside.” I can’t stop thinking about this simple phrase Emily said in our conversation about her story and her book Atlas Girl. As moms, the voice of the girl inside can get drowned out by all the expectation, comparison and busyness of life. Sometimes... Read more

Our contributor Mark Newton loved Emily T. Wierenga’s striking memoir, Atlas Girl and said as much in his review. So when presented with the opportunity to chat with the author herself, we jumped at it. The result is an engaging conversation that examines the book’s central theme of finding home. In addition, Emily discusses the role of art in her upbringing, the challenge of self-promotion, and the non-profit she recently founded, The Lulu Tree. See acast.com/privacy for privacy and opt-out information.

Heartache. Searching. Loneliness. An overwhelming need to be exquisitely loved.   Can you relate? Our guest this week, Emily Wierenga, shares her journey in searching for “home”. She was raised in a Christian home but never felt truly loved. She longed to know she fit in with her own family, turned to an eating disorder and eventually felt healed just to turn back to the eating disorder years later.   Her story will touch your heart, inspire you and fill your heart with hope. Her heart for her family, her adopted family of Uganda and the way she lives out the love and home she has found is special and I am so excited to introduce her to you.   To find out more about Emily's work and her non profit visit thelulutree.com Would you like to win a copy of The Atlas Girl? Leave a comment below about what home feels like to you.

Emily T. Wierenga is an award-winning journalist, artist, and the author of five books, including two books on eating disorders, a subject with which she has first-hand experience. With Atlas Girl: Finding Home in the Last Place I Thought to Look released July 1, 2014, she shares with us her first memoir. See acast.com/privacy for privacy and opt-out information.

Emily Wierenga shares about her journey through anorexia, about caring for her mom with brain cancer, her memoir Atlas Girl, and how to maintain hope, find healing, and some steps we can take to see God despite our pain.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.21.052498v1?rss=1 Authors: Lindhout, F. W., Kooistra, R., Portegies, S., Herstel, L. J., Stucchi, R., Snoek, B. L., Altelaar, M., MacGillavry, H. D., Wierenga, C. J., Hoogenraad, C. C. Abstract: Early neuronal development is a well-coordinated process in which neuronal stem cells differentiate into polarized neurons. This process has been well studied in classical non-human model systems, but to what extent this is recapitulated in human neurons remains unclear. To study neuronal polarization in human neurons, we cultured human iPSC-derived neurons, characterized early developmental stages, measured electrophysiological responses, and systematically profiled transcriptomic and proteomic dynamics during these steps. We found extensive remodeling of the neuron transcriptome and proteome, with altered mRNA expression of ~1,100 genes and different expression profiles of ~1,500 proteins during neuronal differentiation and polarization. We also identified a distinct stage in axon development marked by an increase in microtubule remodeling and apparent relocation of the axon initial segment from the distal to proximal axon. Our comprehensive characterization and quantitative map of transcriptome and proteome dynamics provides a solid framework for studying polarization in human neurons. Copy rights belong to original authors. Visit the link for more info