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Coming up in this episode * Vibe Coding Coming to a Plasma Near You * We Need Another Standard * The Newest of the New 0:00 Cold Open 2:01 Weird Vibes in Qt-Land 21:51 Rust Is Inevitable 41:04 Fedora, Ubuntu and a Journey 1:08:25 Next Time 1:10:24 Stinger The Video Version (https://youtu.be/4Y_u6TPPMvI) https://youtu.be/4Y_u6TPPMvI What a Qt little AI? Qt Blog post (https://www.qt.io/blog/qt-ai-assistant-v0.9-released-deploy-llms-locally-and-enjoy-the-upgraded-user-experience) Phoronoix article (https://www.phoronix.com/news/Qt-Increased-AI-Coding-Caps)
Mike Sharma, MD, MSc, FRCPC - Can We Set a New Standard of Care for Secondary Stroke Prevention? Evaluating Current Gaps and Future Goals
Mike Sharma, MD, MSc, FRCPC - Can We Set a New Standard of Care for Secondary Stroke Prevention? Evaluating Current Gaps and Future Goals
In this episode of the FOF Gym Chat, we're breaking down why everyone—yes, everyone—needs to be lifting heavy. Whether you're in your 30s or your 70s, strength training is key to improving function, protecting your bones, supporting your metabolism, and helping you feel strong and confident in your everyday life. Today, we bust the myths, lay out the benefits, and give you a simple path to start training with purpose. It's never too late to build a stronger body.
ADA-Compliant Design: The New StandardThink accessible design can't be stylish? Think again.In this episode, Anna Lucia of Cataleia Spaces shares how ADA-compliant interiors can be functional and stunning.EP 45 | Home Design Podcast: Join Host Adam Kayce and ADA interior design expert Anna Lucia as we explore the world of inclusive, functional, and stylish spaces.From ADA-compliant kitchens and overlooked design elements to new tech innovations and aesthetic misconceptions, Anna shares expert insights into what it really takes to create accessible homes that don't compromise on style.Whether you're a designer, homeowner, or just passionate about smart design, this episode will open your eyes to the future of interiors—and how accessibility is leading the way.
This week on the Untethered Podcast, Hallie chats with Samy DeBellis, a Feed The Peds®-trained therapist on the path to becoming a Certified Pediatric Feeding Therapist™ (CPFT™).Samy shares her journey into feeding therapy and her passion for making mealtimes safer, more enjoyable, and empowering for families. They dive into the importance of certification, strategies for engaging children, and the role of parent involvement in therapy.If this episode has resonated with you in some way, take a screenshot of you listening, post it to your Instagram Stories, and tag Hallie @halliebulkin and Samy @speechlanguageplaceFor more episodes visit www.untetheredpodcast.com Hosted on Acast. See acast.com/privacy for more information.
Today's Devotional "I Need A New Standard for My Life"Hebrews 3,4lmjministries.org4/9/25Join us for coffee, conversation and community.
This segment discusses a controversial Rutgers University poll suggesting that nearly half of Democrat respondents view the assassination of Donald Trump or Elon Musk as at least somewhat justified. The host criticizes the normalization of political violence on the left, questions whether it's the result of brainwashing or deeper psychological traits, and warns of an escalating cultural and political divide in the U.S.
Chad's back with fitness guru Rob Conaster, and this time they're breaking down the real science behind getting your body right, without overcomplicating things. Why should you be doing lunges, planks, and pushups? Rob explains how each simple move works specific muscles and builds overall strength. They dive into warmups, what they should look like, whether they count as part of the workout, and how they set the tone for your entire session, and get into daily habits you can build to stay strong, how often you should be moving your body, and why consistency beats intensity every time. Plus, they cover calories, healthy snacks, supplements, and how to make your diet and lifestyle support your goals without turning your life upside down. Listen in for some easy listening, straight-up advice from one of the best in the game. Stay healthy! Stay Fit! This episode is brought to you by Sierra Strength and Speed, Jack Daniel's Tennessee Sour Mash Whiskey, Bad Boy Mowers, The Provider Culinary, Napa Valley Olive Oil, Oakley Sunglasses, BO 3.0 Hydration, Corning Ford, BedSlide, Mickey Thompson Tires, Liberty Heritage Apparel, GATR Coolers and Drinkware, Z-Line Appliances, and Jack Link's Protein Snacks.
Who are Fortis? I chat with Oliver Massey Birch the owner of the company and we look back at how it started and where it is today. Requirements for shooting clothing have become more demanding and people want for more for the money these days. Oliver tells us what sort of service you will expect if you step on to a stand at a show.Is Fortis the new front runner in outdoor and shooting clothing?Thats up to you to decided but have a listen and then visit them at one of the many shows around the UK this year. https://fortisclothing.co.uk/_____________________________________________________________________________________ Thinking about doing the PDS1 or PDS2 use the link below.https://www.shootingandhuntingacademy.co.uk/link/6f1QuV Using this link above you will get a Free PDS1 Shooting assessment with myself in scotland Support the showInstagram https://www.instagram.com/the_outdoor_gibbon/
Who's up in the On Deck Circle?Penn State Baseball Head Coach Mike Gambino steps into the On Deck Circle for this week's brand new episode! This week, Christian Helsel & Sal Biasi go in-depth with Head Coach Mike Gambino to explore his vision for transforming the Nittany Lions into college baseball's next big thing. From his obsession with player development to creating a culture of resilience and grit, Coach Gambino shares the big picture of his strategy and what to expect from this season and beyond.Key topics covered in this episode:- How Penn State Baseball is setting a new standard under Coach Gambino's leadership.- The program's commitment to player development and its importance for long-term success.- Exclusive insights into building a winning culture and fostering connections with alumni and fans.- The role of resilience, attention to detail, and team identity in achieving success on and off the field.- The excitement surrounding transfer players like Paxton Kling and their impact on the program.FOLLOW STATE MEDIA HERE:► TWITTER | https://twitter.com/StateMediaPSU► TIKTOK | https://www.tiktok.com/@statemediapsu► INSTAGRAM | https://www.instagram.com/statemediapsu/► YOUTUBE | https://www.youtube.com/@StateMediaPSU?sub_confirmation=1CHAPTERS:00:00 - Intro00:50 - Last Year Overview05:00 - Setting a New Standard in Sports07:52 - Bryce Mangene Insights10:55 - Importance of Language in Coaching13:16 - Impact of Paxton Kling 21:09 - Bringing PA Kids Back to State Programs23:51 - Recruiting Strategies and Trends26:25 - Importance of Fan Support in Sports30:01 - Changing Team Culture Quickly42:01 - Player Development Techniques44:14 - Using Data Analytics for Player Development49:20 - Dollar Dog Night Event54:13 - How Can We Help Coach Initiatives#collegebaseball #mlb #cbb #pennstate #weare #swing #happyvalley
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Welcome back to Beyond Limits! In this solo episode, Liv dives into fully claiming the new standard of your world.Key Takeaways:✨The power of claiming a new standard—where overflow is your default.✨Moving from pressure to pure inevitability—so you stop “trying” and start receiving.✨The energy that collapses time & creates effortless expansion.✨Why you don't need to wait, ask for permission or need to see the proof—your next level is here. Links:Join Rich and Regulated CEO: https://www.keepupwithliv.com/richandregulatedceoJoin the FREE secret Podcast - Regulated: https://keepupwithliv.myflodesk.com/gc1rmymonz Instagram: http://instagram.com/keepupwithliv Website: https://www.keepupwithliv.com/ Pinterest: https://www.pinterest.com/keepupwithliv
Business analysis is evolving—are you keeping up? IIBA hasjust released the next iteration of The Business Analysis Standard, offering a more accessible, practical guide to business analysis that goes beyond just practitioners. This 60-page free business analysis resource simplifies key concepts, making it easier to communicate the value of business analysis, align with leadership, and drive better business outcomes. In this episode, guest, Tyler Kenny, IIBA Product Manager forthe latest version, joins Susan to share his insights on the evolution of the Standard, key improvements, and how it helps organizations drive better outcomes. Whetheryou're a business analyst, product owner, consultant, or leader, this iteration of the Standard (and this episode) has something for you!
The XWA have released two more SL cards for Resistance. Tanner and JJ review the new cards, their interactions and rate how good each of the new pilots are. Links --------- Youtube: https://www.youtube.com/channel/UCRX-7c7R0_FlTZZ2Vtdi_9Q Willow Links: https://wlo.link/@planningphasesyndicate Facebook: https://www.facebook.com/Planning-Phase-Syndicate-102792741982012 Twitch: https://www.twitch.tv/planningphasesyndicate Patreon: https://www.patreon.com/PlanningPhaseSyndicate Discord: https://discord.gg/eqxnTxDFAr Podcast: https://planningphasesyndicate.podbean.com Paypal: https://paypal.me/ppsyndicate
Cultural Icons is here. A new editorial series by Emily McElwreath, spotlighting the spaces, brands, and experiences shaping today's creative landscape.As a curator, art advisor, and cultural journalist, Emily has spent years immersed in the art world, uncovering the people and places that truly move culture forward. Now, she's bringing that insight to Cultural Icons—a definitive selection of the most inspiring destinations, institutions, and brands that understand the intersection of art, design, and experience.In this episode, Emily introduces the vision behind Cultural Icons, how it expands upon The Art Career Podcast, and what's to come. Stay tuned for the first feature this spring.Follow along - Cultural Icons@theartcareer@emily_mcelwreathart
Send us a message!As the hospitality industry evolves, guest screening and verification have become essential components of a safe and seamless guest experience. In this episode, we sit down with Ela Mezhiborsky, President and Co-Founder of AutoHost, to explore how cutting-edge technology is reshaping the way hotels and short-term rental operators manage risk, prevent fraud, and enhance security.Ela shares her insights on the growing role of AI and cybersecurity in guest verification, the challenges of "bad AI" in fraud prevention, and the regulatory changes driving the need for stronger screening solutions. From mandatory ID checks to advanced biometric verification, this conversation unveils the future of trust and safety in hospitality.Key Topics Discussed:1️⃣ The Evolution of AutoHost & Guest Screening2️⃣ The Role of AI in Fraud Detection & "Bad AI" Risks3️⃣ Regulatory Changes & Compliance Trends4️⃣ Hotels vs. Short-Term Rentals: Who's Leading in Security?5️⃣ The Future of Guest Verification & Embedded Security Solutions6️⃣ Addressing Human Trafficking & Ethical Responsibility7️⃣ Where AutoHost is Headed Next8️⃣ Final Thoughts & How to Connect with ElaConnect with Ela:LinkedIn: https://www.linkedin.com/in/elamezhiborsky/ Autohost Website: https://www.autohost.ai/ Ready to take your operations to the next level? Visit https://tnsinc.com/podcasts-alex-and-annie/ to learn more.Get $50 credit and $0 onboarding fee when you sign up for Beyond, the leading dynamic pricing tool for vacation rentals: http://beyondpricing.info/alexandannie#guestscreening #vacationrentals #fraudprevention
Alysia Montaño, an Olympic bronze medalist and founder of For All Mothers, joins Sarah to discuss the inspiration behind her nonprofit, how pregnancy has historically impacted endorsements and brand deals, and what it was like to break a non-disclosure agreement with Nike to shed light on how the company treated pregnant athletes. Plus, Alysia gives flowers to the organizations that have made the biggest strides in ensuring athletes in women’s sports have protections and support around pregnancy and childbirth. Read/watch Alysia’s op-ed in the New York Times here Read more about Alysia’s nonprofit here Leave us a voicemail at 872-204-5070 or send us a note at goodgame@wondermedianetwork.com Follow Sarah on social! Bluesky: @sarahspain.com Instagram: @Spain2323 Follow producer Misha Jones! Bluesky: @mishthejrnalist.bsky.social Instagram: @mishthejrnalist Follow producer Alex Azzi! Bluesky: @byalexazzi.bsky.social See omnystudio.com/listener for privacy information.
(Intro) Feel Good Friday (5TYNTK) Title IX, Tariffs Postponed, Scarborough School Evacuated, Social Security Registration, Daylight Saving Time (Dirty) Post Malone's new girlfriend. Ice Cube sheltering from cyclone. Kobe and Jordan jerseys up for auction. Angie Stone's fraudulent GoFundMe. Reacher Season 3 hits Maine. (Topic) What's something small someone did that forever changed your dating standards? (Outro) Content Creators
Michael chats with Jennifer Sargent, CEO of Pacify. In this episode, Michael and Jennifer discuss Pacify's evolution toward becoming a leading provider of wrap-around support in maternal care, how the organization is transforming maternal health outcomes and overcoming access barriers through accessible tech-enabled doula-led care, and much more.
This podcast was edited on a plane ride to Japan, and the intro was recorded in a bathroom while my kids slept off the jet lag. It's still good. I recently went down with Ben Greenzweig, the Executive Director of the non-profit Living Water Brain Treatment Center in Myrtle Beach, South Carolina. We are—right now—providing TMS treatment and, soon to be more, in a local community in Ben's beloved home of Horry County. There are 400,000 residents and less than 30 psychiatric inpatient beds in the county. There are not enough services to meet the needs he saw in his community—so he started Living Water to help. I'll remind readers that not only did he write an article about it, but he is also running a non-profit. Thus, consider donating.The audio from today's podcast was recorded mainly on my phone, which I had in my pocket as I gave the talk. Please share it with friends. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit thefrontierpsychiatrists.substack.com/subscribe
Small Cap Breaking News You Can't Miss! Here's a quick rundown of the latest updates from standout small-cap companies making big moves todayGreat Atlantic Resources Expands Tungsten Portfolio in New Brunswick (TSXV: GR)Great Atlantic Resources (TSXV: GR) just made a bold move by acquiring 100% interest in the Nashwaak Lake Tungsten Property, strategically located near Northcliff Resources' Sisson Project in western New Brunswick. This acquisition boosts Great Atlantic's critical metals portfolio, with historical rock samples showing impressive tungsten values—reaching as high as 20,300 ppm in 2022. Positioned in one of the world's most secure mining jurisdictions, this expansion could unlock significant long-term value as global demand for tungsten continues to rise.ESGold Reassesses Montauban Project Economics Amid Surging Gold and Silver Prices (CSE: ESAU)As gold and silver hit new highs—$2,930/oz for gold and $32.50/oz for silver—ESGold Corp. (CSE: ESAU) is updating its Preliminary Economic Assessment (PEA) for the Montauban Project in Quebec. The revised PEA aims to reflect the project's stronger cash flow potential, providing a clearer financial outlook for investors. With near-term production on the horizon and a focus on sustainable mining, ESGold is positioning itself as a major player in the clean resource recovery space.HPQ Silicon Sets a New Standard in Lithium-Ion Battery Performance (TSXV: HPQ)HPQ Silicon Inc. (TSXV: HPQ) just delivered a technological knockout with its GEN3 silicon-anode batteries outperforming heavyweights like Samsung and Panasonic. Independent testing showed these batteries retain 82% capacity after 900 cycles, compared to Panasonic's 70% after just 300 cycles—along with a 31% cumulative energy gain. Even better, HPQ's silicon-anode materials integrate seamlessly into existing battery production lines, offering a cost-efficient solution to meet the surging global demand for high-performance energy storage.Koryx Copper Named Top 50 TSX Venture Exchange Company (TSXV: KRY)Koryx Copper Inc. (TSXV: KRY) is making waves, earning a coveted spot among the Top 50 companies on the TSX Venture Exchange for 2025. After a transformative year that saw its share price jump 400% and market cap grow by 737%, Koryx secured a place in the top 10 mining companies on the list. This recognition reflects not just market momentum but the company's strategic execution and long-term value creation.Stay Ahead of the Game!Follow us for more breaking small-cap news and updates. https://open.spotify.com/episode/7GoQSdREliKa4HR9Or2Ok1?si=gycUle7TSXCvrTQ9-UT31g
In this episode of Game Changers for Government Contractors, host Michael LeJeune speaks with cybersecurity expert Jessica Dapelo about the rise of Zero Trust and AI in risk assessment. Jessica explains how Zero Trust flips traditional cybersecurity on its head, ensuring that every device and user must prove legitimacy before gaining access. They discuss the dangers of unchecked AI, the vulnerabilities hidden in everyday technology, and the importance of cybersecurity training. From real-world hacking stories to proactive security strategies, this episode is packed with insights on how businesses and individuals can protect themselves in an increasingly digital world. Tune in to learn why trust is the weakest link in cybersecurity—and how to safeguard your data from evolving threats. ----- Frustrated with your government contracting journey? Join our group coaching community here: federal-access.com/gamechangers Grab my #1 bestselling book, "I'm New to Government Contract. Where Should I Start?" Here: amzn.to/4c5Vb0d
Ep 17 Founder Series Pt 2: A 20-Year Journey to Make Motion Preservation the New Standard in Spine, Scott Hodges, DO In Part 2 of our Founder Series, co-hosts Courtney Schutze and Brady Riesgraf sit down with fellowship-trained, orthopedic spine surgeon Dr. Scott Hodges. Well known by several titles, including Medical Director at 3Spine, co-inventor of MOTUS, and leading advocate for motion preservation in spine surgery, Dr. Hodges shares his behind-the-scenes journey to bringing motion preservation to the forefront of spine care. His enthralling story includes the more than 20-year process of bringing a novel spine implant to market- from initial sketch drawings and early prototypes to clinical trials in South Africa and the U.S. Dr. Hodges' journey began at Southern Adventist University in his current hometown of Chattanooga, Tennessee, followed by medical school at Kansas City University, residency at Ohio University, and his fellowship in spine surgery at Loyola University Chicago School of Medicine. He went on to build a thriving surgical practice in Chattanooga, Tennessee, and it was here that the idea to improve upon the current standard of care for spine patients was formed and flourished. Dissatisfied with the available technologies and long-term patient outcomes in spine, Dr. Hodges dedicated his career to creating a solution. With an aim for creating a better treatment for spine surgery patients, Dr. Hodges partnered with Dr. Craig Humphreys to co-develop MOTUS, the first total joint replacement for the lumbar spine. Their goal was to create an implant that restored function in the lumbar spine and the entire kinetic chain, without sacrificing the body's natural motion. With this new endeavor, Dr. Hodges shifted his focus entirely to bringing these solutions to patients, navigating the complex world of medical device development, and leading surgeon education for this novel approach to spine care. In this episode, you'll learn: The road to innovation: What it takes to develop, refine, and clinically validate a motion-preserving device. What's next for spine surgery: How motion preservation, total joint replacement, facet replacements, and endoscopic techniques are shaping the future of spine care for patients struggling with chronic leg and/or back pain. The origins of MOTUS: How a simple concept became the first lumbar total joint replacement. Patient demand as a driver of care: How patient demand is driving new technologies to the forefront of surgical care. The importance of the kinetic chain: Why motion in all areas of the body is important and how the different joints in the body - knees, hips, ankles, and spine - work together to allow the body to properly function. Why training & education matter: How surgeon training and patient education play a pivotal role in the adoption and access of new technologies for spine care. This episode, recorded between the 3Spine headquarters in Chattanooga, TN and the world-renowned MERI Lab in Memphis, takes you inside the decades-long journey of bringing a new spine device to market, from the first clinical cases in South Africa to FDA trials in the U.S. As a pioneer, innovator, teacher, and leader, Dr. Hodges shares his compelling story of how data, surgeon training, and patient demand for motion preserving devices are driving the future of spine surgery. This episode is a must-watch for spine surgeons, medical innovators, and anyone interested in the future of spine surgery and the journey of bringing a new device to the market. Missed Part 1? Watch our interview with Dr. Craig Humphreys for the full Founder Series! Note: The MOTUS device is currently in the data collection phase of a US IDE FDA Trial and is not available for commercial use at the time of recording. To keep up with the progress of the trial, you can visit www.3Spine.com. Learn more about Dr. Hodges: LinkedIn: https://www.linkedin.com/in/scott-hodges-b7b036122/ You can find The Spine Pod on all Podcast Streaming Platforms, including: YouTube: / @thespinepod Spotify: https://open.spotify.com/show/0DBzWfV... Apple Podcasts: https://podcasts.apple.com/us/podcast... Amazon Music: https://music.amazon.com/podcasts/98f... iHeart Radio: https://www.iheart.com/podcast/269-th... Follow The Spine Pod on Facebook to learn more about the latest episodes and happenings in the world of motion preservation: https://www.facebook.com/profile.php?... The information in this podcast is for educational and informational purposes only and is not intended as medical advice. It does not replace consultation with a qualified healthcare professional. Always seek the advice of your physician or another qualified healthcare provider regarding any medical condition or treatment.
This episode of the Astonishing Healthcare podcast highlights the transformative potential of Judi Health™, the first unified claims processing platform that integrates medical and pharmacy claim administrative workflows and data to create a seamless experience for stakeholders, including patients, providers, and employers. Guests AJ Loiacono (Co-Founder & CEO of Capital Rx) and Dr. Sunil Budhrani (Chief Innovation & Medical Officer) emphasize the limitations of the traditional fee-for-service model and legacy infrastructure in U.S. healthcare, which incentivizes reactive rather than proactive care and can't handle the evolution and complexities of value-based care, respectively. Building on Episode 7 (with Sunil) and Episode 9 (with Ryan Kelly, CTO), AJ and Sunil discuss how Judi Health's innovative design can improve the system by enabling real-time data sharing across medical and pharmacy claims (and ultimately vision, dental, etc.), reducing administrative friction, and offering personalized care through population health strategies. AJ Loiacono reflects on the journey of building Judi Health and the importance of firsthand experience in workflow optimization. Dr. Budhrani stresses the importance of transparency and collaboration among the stakeholders, underlining how Judi Health can break down silos to improve care delivery and outcomes. They offer practical examples of how Judi Health can work, such as diabetic-specific plan designs and improved workflows for cancer care.The conversation closes with a reflection on the team members' strong personal and professional synergies and real-life experience with Judi Health since its launch on January 1.Related Content:Capital Rx Unveils Healthcare's First Unified Pharmacy and Medical Claims Processing PlatformSetting a New Standard for the Future of Pharmacy Benefit AdministrationReplay - Build a Lasting Pharmacy Benefit Strategy with Never Move Again™Signs it is time to change your PBM vendor, and how to overcome common hesitationsPlease visit Capital Rx Insights for more information, including this episode's transcript!
In this episode of the More Alive podcast, I'm thrilled to share an intimate and powerful conversation with Nicole Culver, one of my students and a shining embodiment of The Pleasure Model™ philosophy. Nicole is a seven-figure entrepreneur who didn't just learn the model—she's living proof of how prioritizing pleasure over pressure transforms business, relationships, and life itself. We dive into the story of her journey from hustle-driven burnout to deeply aligned, joy-fueled success. Nicole brought her curious and nuanced questions about what it really means to build wealth and impact with ease—and I got to share the practical, magnetic framework that changed everything for both of us: “Not a penny from pressure, only pleasure.” Tune in as we explore: The subtle shift that freed Nicole to redefine success and wealth in her terms. Why your nervous system needs to rest before it can rise—and how pleasure is the key. How to spot (and stop) sneaky pressure in your business, parenting, or self-care. What happens when you let go of perfectionism and let the muse lead. My personal take on rewiring old scripts about "sacrifice equals success" (spoiler: it doesn't). This isn't just theory—this is about finding aliveness in everything you do, creating from curiosity and play, and magnetizing what you desire most. Whether you're navigating a new season in your business or you're curious about ditching hustle for good, Nicole and I are breaking it all down for you. Grab your headphones, hit play, and let's shift into pleasure together. Join The Pleasure Model™ here. Leave me a voicemail HERE with your question for a chance to have it answered on a future episode! Get notifications when new episodes drop by tapping the "follow" button! And if you loved this episode, follow me on Instagram @love_andreacrowder & let me know by leaving a review!
Are you looking to upgrade your teamwork? Do you realize that you have really high standards? Today, Shannon Waller talks about building partners within entrepreneurial teams. What does it mean to have team partners rather than employees or staff, and how do you build the ultimate dream team in your business? If you're tired of micromanaging, find out how Shannon achieves crazy fast results with team members who act as partners. Download Episode Transcript Show Notes: Shannon has realized she only wants to work with partners, not employees, not staff. One example of a three-way partnership is the Teamwork Triad, which consist of three people who have a Unique Ability® in separate but equal areas of “make it up” (creative vision), “make it real” (execution), and “make it recur” (sustainability). Great partnerships are built around each person being honest about their strengths and areas of Unique Ability. Unique Ability is made up of those activities at which you are capable and confident, but also most love to do. Do you know what you're uniquely exceptional at that you should be doing all the time? Do you know what you should not be doing? Having Imposter Syndrome simply means you're growing and still somewhere in the first three scary stages of The 4 C's Formula®—commitment, courage, or capability—and not yet at the last stage, confidence. To be a great partner, you can't be shy and humble about the things you're really good at. You can't be a partner when you're doing what you're incompetent or merely competent at. You also can't be a partner when you're doing what you're excellent at but have no passion for. When partners work together in Unique Ability® Teamwork, everyone is committed and energized by what they're doing. How can you tell when you have the right partners working together? You get the highest quality results at crazy fast speeds. Being a partner means stepping outside of your preconceived ideas about your role to share the best of yourself: your heart, brain, and will. Resources: Kolbe Unique Ability The Team Success Handbook by Shannon Waller The 4 C's Formula by Dan Sullivan
Bears have set the new standard for which head coaches are paid & Bryan Bulaga tells you how Ben Johnson will be scheming his offensive line (Hour 1) full 1377 Sat, 25 Jan 2025 00:14:29 +0000 OYTVSsAiYpXGaa9ELNcoNTWaRrhr0Si6 sports Spiegel & Holmes Show sports Bears have set the new standard for which head coaches are paid & Bryan Bulaga tells you how Ben Johnson will be scheming his offensive line (Hour 1) Matt Spiegel and Laurence Holmes bring you Chicago sports talk with great opinions, guests and fun. Join Spiegel and Holmes as they discuss the Bears, Blackhawks, Bulls, Cubs and White Sox and delve into the biggest sports storylines of the day. Recurring guests include Bears cornerback Jaylon Johnson, former Bears coach Dave Wannstedt, former Bears center Olin Kreutz, Cubs manager Craig Counsell, Cubs second baseman Nico Hoerner and MLB Network personality Jon Morosi. Catch the show live Monday through Friday (2 p.m. - 6 p.m. CT) on 670 The Score, the exclusive audio home of the Cubs and the Bulls, or on the Audacy app. 2024 © 2021 Audacy, Inc. Sports
Bears have set the new standard in which head coaches are paid full 519 Fri, 24 Jan 2025 21:17:27 +0000 YYBejLitVD4KwTDHbBXRqLbrzvC27Qi4 nfl,chicago bears,sports Spiegel & Holmes Show nfl,chicago bears,sports Bears have set the new standard in which head coaches are paid Matt Spiegel and Laurence Holmes bring you Chicago sports talk with great opinions, guests and fun. Join Spiegel and Holmes as they discuss the Bears, Blackhawks, Bulls, Cubs and White Sox and delve into the biggest sports storylines of the day. Recurring guests include Bears cornerback Jaylon Johnson, former Bears coach Dave Wannstedt, former Bears center Olin Kreutz, Cubs manager Craig Counsell, Cubs second baseman Nico Hoerner and MLB Network personality Jon Morosi. Catch the show live Monday through Friday (2 p.m. - 6 p.m. CT) on 670 The Score, the exclusive audio home of the Cubs and the Bulls, or on the Audacy app. 2024 © 2021 Audacy, Inc. Sports False https://player.amperwavepodcas
In Episode S7E1, the host, Steven Bowcut, and Rita Gurevich, the CEO and founder of SPHERE, discuss the importance of identity hygiene in cybersecurity, emphasizing its continuous nature and role in protecting organizations from identity-related risks. They also discussed the challenges in identity management, the need for automation, and the impact of identity hygiene on cyber insurance costs. The conversation concludes with a discussion on the applicability of these concepts to different verticals and the increasing scope of identity management.
Smart Agency Masterclass with Jason Swenk: Podcast for Digital Marketing Agencies
Have you dedicated time to ensure the health of your email list? If you've built a 15,000-person email list for your business—that's a huge accomplishment! But what if that list isn't performing? If your open rates are as low, that number becomes meaningless. It's not about the quantity of subscribers, but the quality of your engagement. Moreover, if you're not consistently delivering valuable content that keeps you top-of-mind as a problem-solver, then you're not maximizing the potential of your list. Today's featured guest shares his insights on effective email marketing strategies, including optimal content delivery frequency, list maintenance best practices, and how his agency has evolved over the past decade. Drawing from his experience, he advocates for email marketing as a reliable channel that doesn't depend on unpredictable social media algorithms. He believes many companies are overlooking a gold mine by fixating on new client acquisition while neglecting their existing client base. Reade Milner is the co-owner of Rogue Pine, a digital marketing agency focused on the middle of the funnel and email marketing. Reade shares his journey into the world of digital marketing and discusses why many agencies are actually sitting on a gold mine when they're searching for new clients. Reade also shares how often you should be sending value content to your lists, and more. In this episode, we'll discuss: Why most agencies are sitting on a gold mine. How to build a newsletter people will actually want to read. Why 40% is the new 20% in open rates. Subscribe Apple | Spotify | iHeart Radio Sponsors and Resources Smart Pricing Table: Today's episode of the Smart Agency Masterclass is sponsored by Smart Pricing Table, an award-winning proposal software built just for marketing agencies and designed to handle your unique challenges and cut down the time you spend on proposal as much as 90%. Go to smartpricingtable.com/smartagency to see if this is the missing piece your agency needs. Schedule a demo and get 50% OFF for the first two months. How Real-World Experience Shaped a Marketing Career Reade's digital marketing journey began as a high school student, when he worked at a family business and was tasked with figuring out how to build a digital strategy to attract customers online. Looking back, he doesn't know how serious they were in trusting such a young person with an important component of their business. However, Reade took it very seriously since it seemed like a smart thing to learn. The abilities he gained from that experience and then starting and crashing his own business in college helped him continue down the path of marketing and content, working at an agency right after college. According to Reade, going through college taught him nothing about digital marketing or the skills he would continue to develop to succeed in that industry. Instead, it was the Hubspot certifications he completed during his time at that agency what helped him learn the marketing terminology he needed. At that time, he also started to take side projects, which led to eventually starting his own agency. Why Most Marketing Agencies Are Sitting on a Gold Mine Many businesses focus heavily on client acquisition while overlooking the valuable opportunity of growing their relationships with existing clients. These established relationships represent untapped potential for growth, as current clients already understand and trust your services, making them more likely to engage with additional offerings. To remain relevant in these clients' minds, Reade emphasizes the importance of consolidating client contacts from various sources—CRMs, spreadsheets, and databases—into a comprehensive email list and establishing consistent, meaningful communication through targeted content creation. What is stopping most people from grabbing this low-hanging fruit? Many fear that emailing clients too often leads to them unsubscribing from their list. However, the risk of being irrelevant to them is far worse and gets you nowhere. Remember, if you don't ask, the answer will always be no. Regular engagement will ensure customers are aware of your continued growth and ability to address their evolving business challenges. Moreover, satisfied clients often become brand advocates, providing referrals and testimonials that can be invaluable for attracting new business. 3 Key Sections to Build Newsletters People Actually Want to Read When it comes to client communications, Reade believes there's no such thing as too long, just too boring. If the information you offer is useful to people, they won't mind skimming through it to get to the most important aspects. If it's useless, however, they'll ignore it even if it's just a paragraph. If you're just getting started with a newsletter or are trying to establish consistency in your content, Reade recommends having three sections: Original section, where you're leading with value by offering an original piece of content. Curated section with recommendations of social media posts, articles, or videos you recommend. Highlight section, where you can highlight case studies or products or services you offer. It's enough to keep people informed about your services and milestones while not being too overwhelming. Reade also dives into the effectiveness of subject lines and why it lies not in its consistency but in its ability to pique curiosity and draw the reader in. While establishing a recognizable brand can be valuable, he believes in the need for experimentation to generate curiosity. So instead of leading with your company name (ie: The XYZ Newsletter #45) try to create curiosity by leading with a particular piece of information that may be very useful for your audience. Furthermore, testing various subject lines—from intriguing questions to bold statements—can yield insights into what resonates most with the audience. The goal is to spark interest and drive opens, which ultimately leads to deeper engagement with the content itself. Why 40% is the New Standard for Email Open Rates For Reade, 40% is the new 20% in terms of the goal for open rates. Aiming for a 40% open rate might be more appropriate nowadays considering the changes in email platforms and clients that often auto-open emails for security purposes, which can artificially inflate open rates. This is why he recommends recalibrating expectations and focusing on achieving higher engagement metrics that reflect the true interest of your audience. In addition to content quality, list management plays a crucial role in optimizing your email engagement. For Reade, it's worth it to prune your email list to remove subscribers who are no longer interested in your content and thus refine your audience. This improves engagement rates and ensures you communications are reaching individuals genuinely interested in you offerings. It's essential for maintaining a healthy email list that drives meaningful interactions. Interestingly, Reade places less emphasis on clickthrough rates compared to open rates. He recommends embedding complete content within emails rather than relying on external links. While low clickthrough rates aren't necessarily concerning when paired with healthy open rates, they can signal an opportunity to optimize content strategy. This might involve refining newsletter language and call-to-action elements to better guide readers toward desired interactions, especially when specific clickthrough targets exist. The Power of Direct: Why You Shouldn't Overlook the Impact of Email While email marketing might not be considered the most glamorous marketing channel—some even see it as outdated—the data tells a different story. People are forty times more likely to make a purchase after receiving an email from a company than after seeing a social media post. This highlights the power of direct communication. Email marketing allows businesses to connect with their audience personally, fostering engagement and driving sales in a way that social media often can't. Unlike the ever-shifting algorithms of social media platforms, email provides a stable, owned channel for nurturing leads and ensuring consistent outreach to an audience that has already expressed interest in the brand. Do You Want to Transform Your Agency from a Liability to an Asset? Looking to dig deeper into your agency's potential? Check out our Agency Blueprint. Designed for agency owners like you, our Agency Blueprint helps you uncover growth opportunities, tackle obstacles, and craft a customized blueprint for your agency's success.
About the CISO Circuit SeriesSean Martin and Michael Piacente join forces roughly once per month (or so, depending on schedules) to discuss everything from looking for a new job, entering the field, finding the right work/life balance, examining the risks and rewards in the role, building and supporting your team, the value of the community, relevant newsworthy items, and so much more. Join us to help us understand the role of the CISO so that we can collectively find a path to Redefining CyberSecurity for business and society. If you have a topic idea or a comment on an episode, feel free to contact Sean Martin.____________________________Guests: Heather Hinton, CISO-in-Residence, Professional Association of CISOsOn LinkedIn | https://www.linkedin.com/in/heather-hinton-9731911/____________________________Host: Sean Martin, Co-Founder at ITSPmagazine [@ITSPmagazine] and Host of Redefining CyberSecurity Podcast [@RedefiningCyber]On ITSPmagazine | https://www.itspmagazine.com/itspmagazine-podcast-radio-hosts/sean-martinMichael Piacente, Managing Partner and Cofounder of Hitch PartnersOn ITSPmagazine | https://www.itspmagazine.com/itspmagazine-podcast-radio-hosts/michael-piacente____________________________This Episode's SponsorsImperva | https://itspm.ag/imperva277117988LevelBlue | https://itspm.ag/levelblue266f6cThreatLocker | https://itspm.ag/threatlocker-r974___________________________Episode NotesIn this episode of the CISO Circuit Series, part of the Redefining Cybersecurity Podcast on ITSPmagazine, hosts Sean Martin and Michael Piacente welcomed Heather Hinton, seasoned cybersecurity leader, to discuss the evolving responsibilities and recognition of Chief Information Security Officers (CISOs). Their conversation explored the transformative work of the Professional Association of CISOs (PAC), an organization dedicated to establishing standards, accreditation, and support for cybersecurity leaders globally.This episode addressed three critical questions shaping the modern CISO role:How can CISOs build trust within their organizations?What is PAC doing to elevate cybersecurity as a recognized profession?How can CISOs prepare for increasing scrutiny and legal risks?Building Trust: A CISO's Key ResponsibilityHeather Hinton, whose career includes leadership roles like VP and CISO for IBM Cloud and PagerDuty, underscores that trust is foundational for a CISO's success. Beyond technical expertise, a CISO must demonstrate leadership, strategic thinking, and effective communication with boards, executives, and teams. Hinton highlights that cybersecurity should not be perceived as merely a technical function but as a critical enabler of business objectives.The PAC accreditation process reinforces this perspective by formalizing the skills needed to build trust. From fostering collaboration to aligning security strategies with organizational goals, PAC equips CISOs with tools to establish credibility and demonstrate value from day one.Elevating Cybersecurity as a Recognized ProfessionMichael Piacente, Managing Partner at Hitch Partners and co-host of the CISO Circuit Series, emphasizes PAC's role in professionalizing cybersecurity. By introducing a Code of Professional Conduct, structured accreditation programs, and robust career development resources, PAC is raising the bar for the profession. Hinton and Piacente explain that PAC's ultimate vision is to make membership and accreditation standard for CISO roles, akin to certifications we've come to expect and rely upon for doctors or lawyers.This vision reflects a growing recognition of cybersecurity as a discipline critical not only to organizations but to society as a whole. PAC's advocacy extends to shaping global policies, setting professional standards, and fostering an environment where CISOs are equipped to handle emerging challenges like hybrid warfare and AI-driven threats.Preparing for Legal Risks and Industry ChallengesThe conversation also delves into the increasing legal and regulatory scrutiny CISOs face. Piacente and Hinton stress the importance of having clear job descriptions, liability protections, and professional resources—areas where PAC is driving significant progress. By providing legal and mental health support, along with peer-driven mentorship, PAC empowers CISOs to navigate these challenges with confidence.Hinton notes that PAC is also a critical voice in addressing broader systemic risks, advocating for policies that protect CISOs while ensuring they are well-positioned to protect their organizations and society.Looking AheadWith goals to expand its membership to 1,000 and scale its accreditation programs by 2025, PAC is setting the foundation for a more unified and professionalized cybersecurity community. Hinton envisions PAC becoming a global authority, advising governments and organizations on cybersecurity standards and policies while fostering collaboration among professionals.For those aspiring to advance cybersecurity as a recognized profession, PAC offers a platform to shape the future of the field. Learn more about PAC and how to join at TheCISO.org.____________________________Watch this and other videos on ITSPmagazine's YouTube ChannelRedefining CyberSecurity Podcast with Sean Martin, CISSP playlist:
About the CISO Circuit SeriesSean Martin and Michael Piacente join forces roughly once per month (or so, depending on schedules) to discuss everything from looking for a new job, entering the field, finding the right work/life balance, examining the risks and rewards in the role, building and supporting your team, the value of the community, relevant newsworthy items, and so much more. Join us to help us understand the role of the CISO so that we can collectively find a path to Redefining CyberSecurity for business and society. If you have a topic idea or a comment on an episode, feel free to contact Sean Martin.____________________________Guests: Heather Hinton, CISO-in-Residence, Professional Association of CISOsOn LinkedIn | https://www.linkedin.com/in/heather-hinton-9731911/____________________________Host: Sean Martin, Co-Founder at ITSPmagazine [@ITSPmagazine] and Host of Redefining CyberSecurity Podcast [@RedefiningCyber]On ITSPmagazine | https://www.itspmagazine.com/itspmagazine-podcast-radio-hosts/sean-martinMichael Piacente, Managing Partner and Cofounder of Hitch PartnersOn ITSPmagazine | https://www.itspmagazine.com/itspmagazine-podcast-radio-hosts/michael-piacente____________________________This Episode's SponsorsImperva | https://itspm.ag/imperva277117988LevelBlue | https://itspm.ag/levelblue266f6cThreatLocker | https://itspm.ag/threatlocker-r974___________________________Episode NotesIn this episode of the CISO Circuit Series, part of the Redefining Cybersecurity Podcast on ITSPmagazine, hosts Sean Martin and Michael Piacente welcomed Heather Hinton, seasoned cybersecurity leader, to discuss the evolving responsibilities and recognition of Chief Information Security Officers (CISOs). Their conversation explored the transformative work of the Professional Association of CISOs (PAC), an organization dedicated to establishing standards, accreditation, and support for cybersecurity leaders globally.This episode addressed three critical questions shaping the modern CISO role:How can CISOs build trust within their organizations?What is PAC doing to elevate cybersecurity as a recognized profession?How can CISOs prepare for increasing scrutiny and legal risks?Building Trust: A CISO's Key ResponsibilityHeather Hinton, whose career includes leadership roles like VP and CISO for IBM Cloud and PagerDuty, underscores that trust is foundational for a CISO's success. Beyond technical expertise, a CISO must demonstrate leadership, strategic thinking, and effective communication with boards, executives, and teams. Hinton highlights that cybersecurity should not be perceived as merely a technical function but as a critical enabler of business objectives.The PAC accreditation process reinforces this perspective by formalizing the skills needed to build trust. From fostering collaboration to aligning security strategies with organizational goals, PAC equips CISOs with tools to establish credibility and demonstrate value from day one.Elevating Cybersecurity as a Recognized ProfessionMichael Piacente, Managing Partner at Hitch Partners and co-host of the CISO Circuit Series, emphasizes PAC's role in professionalizing cybersecurity. By introducing a Code of Professional Conduct, structured accreditation programs, and robust career development resources, PAC is raising the bar for the profession. Hinton and Piacente explain that PAC's ultimate vision is to make membership and accreditation standard for CISO roles, akin to certifications we've come to expect and rely upon for doctors or lawyers.This vision reflects a growing recognition of cybersecurity as a discipline critical not only to organizations but to society as a whole. PAC's advocacy extends to shaping global policies, setting professional standards, and fostering an environment where CISOs are equipped to handle emerging challenges like hybrid warfare and AI-driven threats.Preparing for Legal Risks and Industry ChallengesThe conversation also delves into the increasing legal and regulatory scrutiny CISOs face. Piacente and Hinton stress the importance of having clear job descriptions, liability protections, and professional resources—areas where PAC is driving significant progress. By providing legal and mental health support, along with peer-driven mentorship, PAC empowers CISOs to navigate these challenges with confidence.Hinton notes that PAC is also a critical voice in addressing broader systemic risks, advocating for policies that protect CISOs while ensuring they are well-positioned to protect their organizations and society.Looking AheadWith goals to expand its membership to 1,000 and scale its accreditation programs by 2025, PAC is setting the foundation for a more unified and professionalized cybersecurity community. Hinton envisions PAC becoming a global authority, advising governments and organizations on cybersecurity standards and policies while fostering collaboration among professionals.For those aspiring to advance cybersecurity as a recognized profession, PAC offers a platform to shape the future of the field. Learn more about PAC and how to join at TheCISO.org.____________________________Watch this and other videos on ITSPmagazine's YouTube ChannelRedefining CyberSecurity Podcast with Sean Martin, CISSP playlist:
Is that the commitment and performance level Man United now have to match week after week? Was that one of the worst weekends for refereeing decisions we've seen for a while? Can Newcastle sustain this run of form and claim a Champions League place? Gary, Alan and Micah also discuss the penalty incident between Joao Pedro and William Saliba and how VAR can be used better to come to the right decision. Sign up to The Rest Is Football newsletter at therestisfootball.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
Bears have set a new standard with their ability to lose games (Hour 1) full 2465 Mon, 23 Dec 2024 20:54:19 +0000 TxFI1ar8gyqam95R9bXbKpa5qjfYaoGO sports Bernstein & Harris Show sports Bears have set a new standard with their ability to lose games (Hour 1) Dan Bernstein and Marshall Harris bring you fun, smart and compelling Chicago sports talk with great listener interaction. The show features discussion of the Bears, Blackhawks, Bulls, Cubs and White Sox as well as the biggest sports headlines beyond Chicago. Leila Rahimi joins the show as a co-host on Wednesdays. Recurring guests include Bears linebacker T.J. Edwards, Pro Football Talk founder Mike Florio, Cubs outfielder Ian Happ and Cubs president of baseball operations Jed Hoyer. Catch the show live Monday through Friday (10 a.m.- 2 p.m. CT) on 670 The Score, the exclusive audio home of the Cubs and the Bulls, or on the Audacy app. © 2024 Audacy, Inc. Sports False https://player.amperwavepodcasting.com?feed-link=https%3A%2F%2Frss.amperwave.net%2Fv
John Maytham is joined by Khaya Sithole, chartered accountant, academic, and activist. With extensive experience in socio-economic policy, he offers valuable insights into South Africa’s spaza shop registration drive and its potential to reshape the informal retail landscape through improved compliance and industry-wide accountability.See omnystudio.com/listener for privacy information.
Send us a textThe Modern Urologist Podcast has launched a new miniseries, Precision Oncology and Prostate Cancer: The New Standard of Care, hosted by Dr. Paul Sieber and Ashleigh Renitsky, Oncology PA. This series will focus on the evolving role of genetic testing in prostate cancer care and its impact on personalized patient treatment plans.Episode #1 - Genetic testing basicsThe first installment will provide an overview of genetic testing, highlighting the difference between germline and somatic testing, and their implications for personalized treatment. This episode emphasizes the importance of integrating streamlined testing protocols into clinical practice, understanding test results to tailor therapies for patients, and leveraging genetic counselors.
Show Topics 1. Numbers Don't Lie (19-0) 2. Winners and Losers 3 Overall Game Grades 4. Wholistic Thoughts Media Links:
In this episode of the Duct Tape Marketing Podcast, I discuss the marketing landscape heading into 2025. With years of experience helping businesses grow through strategic marketing approaches, I reviewed five transformative trends poised to disrupt how marketers, agencies, and organizations connect with audiences in 2025. These trends highlight the increasing role of AI, hyper-personalization, decentralized communities, and authenticity in crafting impactful strategies. I shared actionable insights on leveraging generative AI, exploring platforms like Reddit and Bluesky, and embracing customer-centric values to build trust and loyalty. Whether you're a small business owner or part of a marketing agency, these predictions offer a roadmap for navigating the rapidly evolving digital ecosystem in 2025. I Talk About: [00:48] Hyper-Personalization Powered by Generative AI [02:45] Decentralized Communities and the Shift Away from Traditional Social Media [04:43] Generative AI-Led Creative Production [07:50] AI-Driven Marketing Orchestration [09:42] Brand Marketing as the New Standard [11:14] AI Transparency and Consumer Trust [13:00] Closing Thoughts & Actionable Advice for 2025 More about John Jantsch: Check out John Jantsch's agency and consultancy Duct Tape Marketing at https://ducttapemarketing.com/ Connect with John Jantsch on LinkedIn - https://www.linkedin.com/in/ducttapemarketing/ Get free stuff & sign up for his weekly newsletter - https://ducttapemarketing.com/dtmnews/ Rate, Review, & Follow If you liked this episode, please rate and review the show. Scroll to the bottom, tap to rate with five stars, and select “Write a Review.” Then, let us know what you loved most about the episode.
In this episode of Skin Anarchy, host Dr. Ekta welcomes Maxwell Stock, founder and CEO of Epicutis, to explore the brand's science-first approach to skin health and its latest innovation, the Arctigenin Brightening Treatment (ABT). Known for its minimalist, results-driven formulations, Epicutis is redefining professional skincare.Max shares how his personal struggles with reactive skin inspired him to create a line focused on reducing inflammation and improving skin health. Leveraging his biotech background, he developed Epicutis to prioritize quality, transparency, and efficacy over flashy marketing or "fluff" ingredients. Collaborating with experts like Masanori Tamura, Epicutis delivers clinically-backed products designed to strengthen the skin barrier and enhance its natural function.A standout of the episode is the ABT, a groundbreaking brightening product six years in the making. Unlike harsh brightening agents like vitamin C, ABT harnesses arctigenin, a natural compound from burdock seed, to reduce melanin production gently and effectively. Safe for all skin types, including sensitive and skin of color, ABT represents the next generation of brightening treatments.Max also discusses Epicutis's professional-first philosophy, emphasizing education and expertise. By working with skincare professionals, the brand empowers consumers to make informed decisions about their skin health.If you're ready to shift your skincare focus from anti-aging to overall skin health, this episode offers a deep dive into Epicutis's innovative, science-driven solutions that deliver results without compromise. Tune in to discover how Epicutis is elevating skincare with integrity and simplicity.To learn more about Epicutis, visit their website and social media. Don't forget to subscribe to Skincare Anarchy on Apple Podcasts, Spotify, or your preferred platform. Reach out to us through email with any questions.Shop all our episodes and products mentioned through our ShopMy Shelf! Hosted on Acast. See acast.com/privacy for more information.
Dr. Linda Duska and Dr. Domenica Lorusso discuss the practice-changing results of the phase 3 ENGOT-cx11/GOG-3047/KEYNOTE-A18 study, which evaluated pembrolizumab plus chemoradiotherapy as treatment for previously untreated, high-risk, locally advanced cervical cancer. TRANSCRIPT Dr. Linda Duska: Hello, I'm Linda Duska, your guest host of the ASCO Daily News Podcast today. I'm a professor of obstetrics and gynecology and serve as the associate dean for clinical research at the University of Virginia School of Medicine. On today's episode, we'll be discussing a new standard of care for previously untreated, high- risk locally advanced cervical cancer. This follows the ENGOT-cx11/GOG-3047/KEYNOTE-A18 study, which I will be referring to as KEYNOTE-A18 for the rest of this podcast, which demonstrated that pembrolizumab plus chemoradiotherapy improved both progression-free and overall survival compared to chemoradiotherapy alone. I was a co-author of this study, and I'm delighted to be joined today by the study's lead investigator, Dr. Domenica Lorusso, for today's discussion. She is also a professor of obstetrics and gynecology. She's at Humanitas University Rosano and the director of the Gynecologic Oncology Unit at the Humanitas Hospital San Pio in Milan, Italy. Our full disclosures are available in the transcript of this episode. Dr. Lorusso, it's great to be speaking with you today. Dr. Domenica Lorusso: Thank you, Linda. It's a great pleasure to be here. Thank you. Dr. Linda Duska: So I was hoping you could start us out with some context on the challenges associated with treating patients with high-risk, locally advanced cervical cancer. Dr. Domenica Lorusso: Yes. I have to make a disclosure because in my experience as a gynecologist, cervical cancer patients are the most difficult patients to treat. This is a tumor that involves young patients [who often have] small kids. This is a very symptomatic tumor. More than 50% of patients report pain. Sometimes the pain is difficult to control because there is an infiltration of the pelvic nerves and also a kind of vaginal discharge, so it's very difficult to treat the tumor. Since more than 25 years, we have the publication of 5 randomized trials that demonstrate that when we combine platinum chemotherapy to radiation treatment, we increase overall survival by 6%. This is the new standard of care – concurrent chemoradiation plus brachytherapy. This is a good standard of care because particularly modern, image-guided radiotherapy has reported to increase local control. And local control in cervical cancer translates to better overall survival. So modern radiotherapy actually is able to cure about 75% of patients. This is what we expect with chemoradiation right now. Dr. Linda Duska: So what are the key takeaways of A18? This is a really exciting trial, and you've presented it a couple of times. Tell us what are the key takeaways that you want our listeners to know. Dr. Domenica Lorusso: Linda, this is our trial. This is a trial that we did together. And you gave me the inspiration because you were running a randomized phase 2 trial exploring if the combination of pembrolizumab to concurrent chemoradiation was able to give signals of efficacy, but also was feasible in terms of toxicity. There were several clinical data suggesting that when we combine immunotherapy to radiotherapy, we can potentially increase the benefit of radiotherapy because there is a kind of synergistic effect between the two strategies. Radiotherapy works as a primer and immunotherapy works better. And you demonstrated that it was feasible to combine immunotherapy to concurrent chemoradiation. And KEYNOTE-A18 was based on this preliminary data. We randomized about 1,060 patients to receive concurrent chemoradiation and brachytherapy or concurrent chemoradiation and brachytherapy in combination with pembrolizumab followed by pembrolizumab for about two years. Why two years? Because in more than 80% of cases, recurrence in this patient population occurred during the first two years. So the duration of treatment was based on the idea to provide protection to the patient during the maximum time of risk. And the trial had the two primary endpoints, progression free and overall survival, and met both the endpoints, a significant 30% reduction in the risk of progression that was confirmed. At the 3-year follow up, the observation was even better, 0.68. So 32% reduction in the risk of progression. And more importantly, because this is a curative setting, 33% reduction in the risk of death was reported in the experimental arm when pembro was combined with chemoradiation. Dr. Linda Duska: That's amazing. I wanted to ask you, a prior similar study called CALLA was negative. Why do you think A18 was positive? Dr. Domenica Lorusso: Linda, there are several discussions about that. I had the possibility to discuss several times with the PI of CALLA, Brad Monk. The idea of Brad is that CALLA was negative because of using durvalumab instead of PD-1 inhibitor, which is pembrolizumab. I do not have exactly the same impression. My idea is that it's the kind of patient population enrolled. The patient population enrolled in KEYNOTE-A18 was really a high-risk population; 85% of that patient were node positive, where the definition of node positivity was at least 2 lymph nodes in the pelvis with a short diameter of 1.5. So, we are very confident this patient was node-positive, 55% at the grade 3 and 4 diseases. So this is really a high-risk population. I remember at the first presentation of CALLA, I was honored to discuss the CALLA trial when it was first presented at IGCS a few years ago. And when I received the forest plot of Calla, it was evident to me that in patients with stage III and node positive there was a signal of efficacy. And we have a huge number of patients with node positive. So in my opinion this is the reason why KEYNOTE-A18 is positive. Dr. Linda Duska: Yeah, I agree with you. I've thought about it a lot and I think you're right about that. The INTERLACE trial results were recently published. How should we interpret these results in the context of A18? Dr. Domenica Lorusso: So it's very difficult to compare the 2 trials. First of all, in terms of population. The population enrolled in INTERLACE is a low-risk, locally advanced but low risk population; 76% were stage II, 10% were stage I, 60% were node-negative patients. So, first of all, the population is completely different. Second is the type of radiotherapy that was provided. INTERLACE is a 10-year long trial, but in 10 years the quality and the technique of radiotherapy completely changed. Only 30% of patients in INTERLACE received what we call the modern image-guided brachytherapy, which is important because it provides local control and local control increases overall survival. And third, we read the paper. I'm not a methodologist, but there are some methodological biases in the paper. All the statistical design of the trial was based on PFS, but PFS was evaluated at physician description. And honestly, I never saw a trial that had no pre-specified timeline for radiological evaluation. It's very difficult to evaluate progression in cervical cancer because the fibrosis related to radiotherapy changes the anatomy in the pelvis. And I think that the radiological evaluation is important to address if the patient is progressing or not. Particularly, because the conclusion of CALLA is that the PFS was mainly in favor of distant metastasis. So really, it's difficult for me to understand how distant metastasis may be evaluated with the vagina visit. So really, it's very difficult to compare the two trials, but I have some concerns. And also because of toxicity in the study, unfortunately 30% of patients did not complete concurrent chemoradiation because of residual toxicity due to induction chemotherapy. So I wanted to be sure in the context of modern radiotherapy, if really induction chemo adds something to modern radiotherapy. Dr. Linda Duska: Well, I have two more questions for you. As we move immunotherapy into the front line, at least for these high risk locally advanced cervical cancer patients that were eligible for A18, what does that mean then for hopefully those few that develop recurrence in terms of second line therapy? Dr. Domenica Lorusso: Well, Linda, this is a very important question. We do not have data about immuno after immuno, but I would not completely exclude this hypothesis because in KEYNOTE-A18, the patient received treatment for a well-defined time period. And for those patients not progressing during immunotherapy, I really guess if there is a space for the reintroduction of immunotherapy at the time of recurrence. In this moment we have 30% of patients in KEYNOTE-A18 in the control arm that receive immunotherapy after progression, but still we have 11% of patients that receive immunotherapy in combination with concurrent chemoradiation and then receive, again, immunotherapy in later line of therapy. I think we need to collect these data to capture some signals and for sure we have the new drug. We have antibody drug conjugate. The trials are ongoing exploring the role of antibody drug conjugate, particularly in immune pretreated patients. So I think this is a very interesting strategy. Dr. Linda Duska: I was going to ask you, “What are the next steps,” but I think you already answered that question. You talked about the second line. If you were going to redesign a study in the frontline, what would it look like? Dr. Domenica Lorusso: Probably one question that I would like to answer – there are two questions in my opinion in KEYNOTE-A18 – one is induction immunotherapy. Linda, correct me if I'm wrong, you reported very interesting data about the immune landscape change when you use induction immunotherapy. And I think this is something that we need to explore in the future. And the second question is the duration of maintenance. Because, again, we decided for two years based only on the epidemiology of recurrence, but I guess if one year may be enough. Dr. Linda Duska: I think this sequencing question is really important, that the induction immunotherapy was actually GY017. I can't take credit for that, but I think you're right. I think the sequencing question is really important. Whether you need the concurrent IO or not is an important question. And then to your point about the 2 years, the length of the need for maintenance therapy is a question that we don't know the answer to. So there are lots of really important questions we can continue to ask. I want to thank you so much for sharing your valuable insights with us on the podcast today. You're always so thoughtful about this particular study and cervix cancer in general and also for your great work to advance the care for patients with GYN cancers. Dr. Domenica Lorusso: Thank you, Linda. It's our work - we progress together. Dr. Linda Duska: Yes. And we thank the patients as well. The over 1,000 patients that went on this trial during a pandemic. Right? Dr. Domenica Lorusso: Absolutely. Without their generosity and their trust, we would not be able to do this trial. Dr. Linda Duska: So we're very grateful to them and we thank our listeners for your time today. If you value the insights that you hear on the ASCO Daily News Podcast, please take a moment to rate, review and subscribe wherever you get your podcasts. Thank you all. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement. Follow today's speakers: Dr. Linda Duska @Lduska Dr. Domenica Lorusso Follow ASCO on social media: @ASCO on Twitter ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Linda Duska: Consulting or Advisory Role: Regeneron, Inovio Pharmaceuticals, Merck, Ellipses Pharma Research Funding (Inst.): GlaxoSmithKline, Millenium, Bristol-Myers Squibb, Aeterna Zentaris, Novartis, Abbvie, Tesaro, Cerulean Pharma, Aduro Biotech, Advaxis, Ludwig Institute for Cancer Research, Leap Therapeutics Patents, Royalties, Other Intellectual Property: UptToDate, Editor, British Journal of Ob/Gyn Dr. Domenica Lorusso: Consulting or Advisory Role: PharmaMar, AstraZeneca, Clovis Oncology, GSK, MSD, Genmab, Seagen, Immunogen, Oncoinvest, Corcept, Sutro Biopharma, Novartis, Novocure, Daiichi Sankyo/Lilly Speakers' Bureau: AstraZeneca, Clovis, GSK, MSD, ImmunoGen, Seagen Research Funding (Inst.): PharmMar, Clovis, GSK, MSD, AstraZeneca, Clovis Oncology, Genmab, Seagen, Immunogen, Incyte, Roche, Pharma&, Corcept Therapeutics, Alkermes Travel, Accommodations, Expenses: AstraZeneca, Clovis, GSK, Menarini
Our guest on the podcast today is Anne Tergesen. Anne is a reporter covering retirement for The Wall Street Journal. Her stories often explore how retirement and preparing for retirement are changing today. She writes frequently on topics related to 401(k) plans and retirement savings, spending, and legislation. She also writes about employee benefits, longevity, and aging. Before joining the Journal, Anne worked for BusinessWeek magazine covering personal finance. Together with colleagues, she recently won a Front Page Award from the News Women's Club of New York and was a finalist for Gerald Loeb Award. She was awarded a Knight-Bagehot Fellowship at Columbia University's Graduate School of Journalism and won a Best of Knight-Bagehot Award in 2006. Anne started her career covering local news at The Philadelphia Inquirer.BackgroundBioThe Wall Street Journal articles401(k)s and Retirement“More Americans Are Treating Their 401(k)s Like Cash Machines,” by Anne Tergesen, wsj.com, March 11, 2024.“6% of Your Paycheck Is Becoming the New Standard for 401(k) Saving,” by Anne Tergesen, wsj.com, June 28, 2024.“The 401(k) Investors Convinced That Target-Date Funds Miss the Mark,” by Anne Tergesen and Oyin Adedoyin, wsj.com, Aug. 3, 2024.“The 401(k) Rollover Mistake That Costs Retirement Savers Billions,” by Anne Tergesen, wsj.com, July 22, 2024.“Is Your Company's 401(k) Match Unfair?” by Anne Tergesen, wsj.com, May 25, 2024.“Retire at 65? It's More Like 62,” by Anne Tergesen, wsj.com, April 25, 2024.“David John: Improving the Retirement System,” The Long View podcast, Morningstar.com, Sept. 27, 2022.Automatic: Changing the Way America Saves, by William Gale, Mark Iwry, and David John“The Way We Retire Now,” a Wall Street Journal Series by Anne Tergesen and Veronica Dagher.“Here's What Retirement Looks Like in America in Six Charts,” by Anne Tergesen, Veronica Dagher, and Rosie Ettenheim, wsj.com, March 31, 2023.“She's a Retirement Authority—And Still Made Mistakes. Here's What She'd Do Differently,” by Anne Tergesen, wsj.com, Oct. 12, 2024.“Is There Really a Retirement-Savings Crisis?” by Anne Tergesen, wsj.com, April 23, 2017.OtherVanguard's “How America Saves 2024”“The U-Shape of Happiness Across the Life Course: Expanding the Discussion,” by Nancy Galambos, Harvey Krahn, Matthew Johnson, and Margie Lachman, National Library of Medicine, July 1, 2021.Employee Benefit Research InstituteDavid Blanchett“The Retirement Crisis: Perception Vs. Reality,” by PGIM Global Communications, pgim.com, July 9, 2024.Laura SaundersMichael Kitces
In this week's Omni Talk Retail Fast Five news roundup, sponsored by the A&M Consumer and Retail Group, Ownit AI, Avalara, Mirakl, and Ocampo Capital, Chris and Anne discuss: - Amazon setting aggressive price targets for its rival online store to Temu and Shein - 7-Eleven's “New Standard” format which it plans open across 600 new stores - Simbe's $50 million Series C funding round led by Goldman Sachs Alternatives - Wayfair's new paid subscription loyalty program - And closed with a discussion inspired by Marks & Spencer around the now, next, and future of self-checkout within the fitting room There's all that, plus Doug Tiffan from AWS stops by for 5 Insightful Minutes about AI investments in the fashion & apparel space, along with pre-fab housing, waltzing, and basketball stories from when Chris was a strapping young lad. Music by hooksounds.com
In today's episode, I sit down with Audie Attar, the founder and CEO of Paradigm Sports, who's best known for managing Conor McGregor. Audie shares his journey from being an athlete to becoming a leading sports agent, driven by his passion for advocacy and entrepreneurship. We talk about the importance of creating real value, building purpose-driven businesses, and maintaining authenticity in a world that can easily focus on quick gains. Audie explains how forward thinking and having a clear vision helped him shape his success and create a lasting impact, including how he navigated challenges to build Paradigm Sports into a powerhouse.
Note: "Act 2" will be a separate published audio podcast.*Check out EZ's morning radio show "The InZane Asylum Q100 Michigan with Eric Zane" Click here*Get a FREE 7 day trial to Patreon to "try it out."*Watch the show live, daily at 8AM EST on Twitch! Please click here to follow the page.Email the show on the Shoreliners Striping inbox: eric@ericzaneshow.comTopics:*EZ makes ass out of himself when interviewing Brian VanderArk from The Verve Pipe*Brian told EZ an amazing story about his problems when his band opened up for KISS.*EZ hits rock bottom after David, the Chinese/ Italian from AE Heating and Cooling sees the way EZ lives.*Lots of fun interaction with "The Chat.*Kenney tells the audience, no less than 10 times, that he's not happy with the ads on Twitch.*Talk about Dad's dementiaSponsors:Estate-Wise, Impact Power Sports, Frank Fuss / My Policy Shop Insurance, Kings Room Barbershop, A&E Heating and Cooling, The Mario Flores Lakeshore Team of VanDyk Mortgage, Shoreliners Striping, Ervines Auto Repair Grand Rapids Hybrid & EV, TC PaintballInterested in advertising? Email eric@ericzaneshow.com and let me design a marketing plan for you.Contact: Shoreliners Striping inbox eric@ericzaneshow.comDiscord LinkEZSP TikTokSubscribe to my YouTube channelHire me on Cameo!Tshirts available herePlease subscribe, rate & write a review on Apple Podcastspatreon.com/ericzaneInstagram: ericzaneshowTwitterOur Sponsors:* Check out Mint Mobile: https://mintmobile.com/ZANESupport this podcast at — https://redcircle.com/the-eric-zane-show-podcast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
Note: "Act 1" was a separate published audio podcast.*Check out EZ's morning radio show "The InZane Asylum Q100 Michigan with Eric Zane" Click here*Get a FREE 7 day trial to Patreon to "try it out."*Watch the show live, daily at 8AM EST on Twitch! Please click here to follow the page.Email the show on the Shoreliners Striping inbox: eric@ericzaneshow.comTopics:*Nick, the electrician is rolling in cheddar due to his skilled trades knowledge!*We could all be rich from gold! (Sort of, if it weren't impossible).*Florida AI storm surge to illustrate what people in Florida WILL go through.*Apparently it's not ok to simulate brandishing a weapon when a football player scores a touchdown.*Dua Lipa gives you a recipe for a new drink!*Asshole of the Day BTYB TC PaintballSponsors:Estate-Wise, Impact Power Sports, Frank Fuss / My Policy Shop Insurance, Kings Room Barbershop, A&E Heating and Cooling, The Mario Flores Lakeshore Team of VanDyk Mortgage, Shoreliners Striping, Ervines Auto Repair Grand Rapids Hybrid & EV, TC PaintballInterested in advertising? Email eric@ericzaneshow.com and let me design a marketing plan for you.Contact: Shoreliners Striping inbox eric@ericzaneshow.comDiscord LinkEZSP TikTokSubscribe to my YouTube channelHire me on Cameo!Tshirts available herePlease subscribe, rate & write a review on Apple Podcastspatreon.com/ericzaneInstagram: ericzaneshowTwitterOur Sponsors:* Check out Mint Mobile: https://mintmobile.com/ZANESupport this podcast at — https://redcircle.com/the-eric-zane-show-podcast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
In this video, Dr. Rob Whitfield takes a deep dive into the intersection of breast implants and holistic health, covering important topics like bacterial contamination, environmental toxins, and the recovery process. From discussing common breast implant problems to exploring research on patient outcomes, this comprehensive guide will help you understand the risks and benefits of breast implants, as well as alternatives like fat transfers. #plasticsurgery #asthetic #wellness Dr. Rob Whitfield IG: @breastimplantillnessexpert Show Notes: 00:00:03 - Introduction to Breast Implants 00:01:00 - Overview of Breast Implant Problems 00:02:29 - Understanding Bacterial Contamination 00:03:52 - The Short Method and Environmental Toxins 00:05:14 - Research on Breast Implant Success and Health Factors 00:06:11 - Patient Populations and Their Experiences 00:07:48 - Defining Breast Implant Illness 00:09:07 - Study Findings on Bacterial Contamination Rates 00:10:37 - Importance of Infection Prevention for Implant Patients 00:11:50 - Discuss the Importance of Regular Conversations About Implant Safety 00:12:03 - Personal Experiences with Long-Term Implant Use 00:12:47 - Introduction to Fat Transfers as an Alternative 00:13:48 - Identifying Toxins and Their Impact on Health 00:14:28 - Introduction to Urolithinate and Its Benefits 00:17:29 - Common Toxins Found in Environments and Foods 00:18:28 - Importance of Detoxification and Supporting Immunity 00:19:48 - Discuss Dietary Changes for Reducing Inflammation 00:20:41 - Challenges of Detoxification and Hormonal Imbalance 00:21:15 - Integrating Nutrition and Environmental Toxins in Medical Practice 00:21:56 - Training and Patient Care Insights 00:22:21 - Adapting to Better Testing for Patient Recovery 00:23:01 - The Importance of Mindset in Recovery 00:23:33 - Identifying Patient Discomfort and Treatment Approaches 00:24:12 - Benefits of Hyperbaric Oxygen Therapy 00:24:51 - Sauna Use and Breast Implants: Precautions 00:25:39 - Address Questions on Infrared Sauna Effects 00:27:16 - Female Patient Compliance and Treatment Execution 00:28:37 - Understanding the Short Method for Surgery Preparation 00:29:51 - Enhancing Patient Experience with Anesthesia 00:30:47 - The Role of Genetics in Patient Care 00:31:38 - Food as Medicine: Dietary Recommendations 00:32:11 - Address Concerns About Implant Removal and Safety 00:32:40 - Understanding the Safety of Scar Capsule Removal 00:33:20 - The Importance of Removing Bacterial Contaminants 00:34:06 - The Challenge of Patient Advocacy and Research 00:34:44 - Insights on Bacterial Biofilm and Immune Response 00:35:23 - Address Recovery with the Sharp Method 00:35:51 - Setting a New Standard for Surgical Recovery 00:36:03 - Access to the Sharp Book and Resources 00:36:32 - Educational Videos and Patient Stories on YouTube 00:36:36 - Encouragement to Explore the Sharp Method 00:36:49 - Closing Remarks and Appreciation === Thank you to our sponsors! Timeline Visit https://timelinenutrition.com/drg and use code DRG to get 10% off Active Skin Repair Visit activeskinrepair.com and use code DRG to get 20% off. === Be sure to like and subscribe to #HealThySelf Hosted by Doctor Christian Gonzalez N.D. Follow Doctor G on Instagram @doctor.gonzalez https://www.instagram.com/doctor.gonzalez/
Today, choosing the right phone plan could save you up to $1500 a year. Clark introduces our new Phone Plan Finder tool to help you cut through the confusion and make that choice much easier. Then Clark discusses a great new retirement savings option for part-time and self-employed workers. Also - It's vital to understand your liability risks and insure accordingly, which for many, includes umbrella insurance. New Roth Options: Segment 1 Ask Clark: Segment 2 Liability Insurance: Segment 3 Ask Clark: Segment 4 Mentioned on the show: Phone Plan Finder – Find the Best Plan For You - Clark.com Changes in Retirement Savings Rules to Know Before Year's End - WSJ 6% of Your Paycheck Is Becoming the New Standard for 401(k) Saving The 3 Biggest Mistakes You Can Make With Your 401(k) The 401(k) Rollover Mistake That Costs Retirement Savers Billions - WSJ 401(k) Rollover: How To Roll Over a 401(k) (Clark.com) What Is a SEP IRA and Who Is Eligible? What Is a SIMPLE IRA and How Does It Work? Certificate of Deposit (CD): What Is It, Best Places To Open One What Is a Roth 401(k) and How Does It Work? Rollovers From a 529 Plan to Roth IRA: What to Know Umbrella Insurance Covers Worst-Case Scenarios. There Are Now More of Them. - WSJ What Is Umbrella Insurance and Do You Need It? (Clark.com) 6 Things To Know Before Contacting the National Foundation for Credit Counseling Why Clark Says You Should ‘Ignore' Paze as Trendy New Payment Option Clark.com resources Episode transcripts Community.Clark.com Clark.com daily money newsletter Consumer Action Center Free Helpline: 636-492-5275 Learn more about your ad choices: megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices