Podcasts about oral contraceptives

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Best podcasts about oral contraceptives

Latest podcast episodes about oral contraceptives

Conquering Your Fibromyalgia Podcast
Ep 199 The Hormone-Migraine Link: Breaking the Cycle

Conquering Your Fibromyalgia Podcast

Play Episode Listen Later Apr 16, 2025 31:12


Text Dr. Lenz any feedback or questions This episode dives into the complex relationship between migraines and hormonal changes, particularly focusing on estrogen. The discussion covers the prevalence of migraines, the distinction between migraines with and without aura, and the significant impact of reproductive hormones on migraine patterns, especially in women. Key topics include the discovery of the estrogen threshold, the influence of estrogen on neurotransmitter systems like serotonin and glutamate, and the potential of hormone-based treatments. The episode also examines the role of the trigeminal vascular system, calcitonin gene-related peptide (CGRP), and the impact of oral contraceptives on migraine frequency and intensity. Practical strategies for managing menstrual migraines and the importance of using headache diaries for accurate diagnosis are highlighted.00:00 Introduction to Migraines00:20 Types of Migraines and Auras00:42 Sex Differences in Migraine Prevalence00:59 Hormonal Influence on Migraines01:53 Estrogen's Role in Menstrual Migraines02:05 Historical Breakthroughs in Migraine Research02:35 Estrogen Threshold and Migraine Triggers04:10 Estrogen's Impact on Brain Function07:29 Neurotransmitters and Migraine Pathways11:15 Oxytocin and Migraine Prevention13:20 Trigeminal Vascular System and Migraines16:46 Calcitonin Gene-Related Peptide and Inflammation20:38 Oral Contraceptives and Migraine Management24:59 The Importance of Headache Diaries26:45 Conclusion and Future Research Click here for the Fibromyalgia 101 link.Click here to connect with Joy Lenz. Support the showWhen I started this podcast—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That's why I created this space: to offer education, validation, and hope. If you've been told fibromyalgia “isn't real” or that it's “all in your head,” know this—I see you. I believe you. You're not alone. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you'll find trusted, evidence-based insights here, drawn from my 28+ years as an MD. Please remember to talk with your doctor about your symptoms and care. This content doesn't replace personal medical advice.* ...

Born to Heal Podcast with Dr. Katie Deming
The Hidden Dangers of Birth Control and the New Approach to Hormonal Balance with Dr. Monique Ruberu, Holistic Gynecologist | EP 83

Born to Heal Podcast with Dr. Katie Deming

Play Episode Listen Later Feb 18, 2025 54:23


Download Your Free Guide - 3 Things You Need to Know About Cancer:  https://www.katiedeming.com/cancer-101/Ever wondered why birth control is prescribed as a universal solution for women's health issues? Dr. Katie Deming welcomes Dr. Monique Ruberu, a holistic gynecologist who left conventional medicine to help women find natural solutions for hormone health. After years of prescribing birth control as the default solution, Dr. Ruberu discovered there was a better way to address women's health concerns by understanding the root causes.Learn how your menstrual cycle is a window into your overall health. Dr. Ruberu shares practical ways to identify hormone imbalances through simple observations, and explains why conventional hormone testing often misses crucial information. Chapters:03:58 - Truth about hormonal imbalances  14:26 - Unexplained infertility26:00 - Signs your estrogen is out of control  39:00 - Struggling with menopause? 48:40 - How cycle tracking strengthens relationshipsFrom thyroid function to gut health to adrenal support, discover how these systems work together to influence your hormones. Dr. Ruberu offers accessible, natural approaches to common women's health concerns that go beyond just masking symptoms. Listen and learn why supporting your body's natural processes, rather than suppressing them.Connect with Dr. Monique Ruberu: https://www.naturalwomenshealth.com/Send us a text with your question (include your phone number)Watch & Listen to Born to Heal on Youtube: Click Here Transform your hydration with the system that delivers filtered, mineralized, and structured water all in one. Spring Aqua System: https://springaqua.info/drkatie Don't Face Cancer Alone"The 6 Pillars of Healing Cancer" workshop series provides you valuable insights and strategies to support your healing journey - Click Here to Enroll MORE FROM KATIE DEMING M.D. Free Guide - 3 Things You Need to Know About Cancer: https://www.katiedeming.com/cancer-101/6 Pillars of Healing Cancer Workshop Series - Click Here to EnrollWork with Dr. Katie: www.katiedeming.comFollow Dr. Katie Deming on Instagram: The.Conscious.Oncologist Take a Deeper Dive into Your Healing Journey: Dr. Katie Deming's Linkedin Here Please Support the Show Share this episode with a friend or family member Give a Review on Spotify Give a Review on Apple Podcast DISCLAIMER:The Born to Heal Podcast is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider.

Practical Talks for Family Docs
BS Medicine Episode #595: How to slow the flow: Combined oral contraceptives

Practical Talks for Family Docs

Play Episode Listen Later Feb 5, 2025 28:52


In episode 595, Mike and James invite Jennifer Young back to talk about the use of combined oral contraceptives for heavy menstrual bleeding (benign etiology) and see if they improve patient outcomes. They do! Have a listen to get all the numbers and see how they compare to using levonorgestrel-containing intrauterine devices or NSAIDs. Show notes Tools for Practice 1) How to Slow the Flow: Combined oral contraceptives 2) How to Slow the Flow: Tranexamic acid for heavy menstrual bleeding 3) How to Slow the Flow: Levonorgestrel intrauterine systems for heavy menstrual bleeding 4) How to Slow the Flow: NSAIDs for Heavy Menstrual Bleeding

Best Science Medicine Podcast - BS without the BS
Episode 595: How to slow the flow: Combined oral contraceptives

Best Science Medicine Podcast - BS without the BS

Play Episode Listen Later Jan 3, 2025 28:51


In episode 595, Mike and James invite Jennifer Young back to talk about the use of combined oral contraceptives for heavy menstrual bleeding (benign etiology) and see if they improve patient outcomes. They do! Have a listen to get all the numbers and see how they compare to using levonorgestrel-containing intrauterine devices or NSAIDs. Show […]

The Brain Candy Podcast
876: Lisa Frank, Female Athletes, & Japanese Death Row

The Brain Candy Podcast

Play Episode Listen Later Jan 2, 2025 58:03


Happy New Year, Brainiacs! It's 2025 and Sarah is feeling alive and as usual she is optimistic about this year. Which means it will be a great year (or not! who knows!) We learn how listening to certain songs can reframe your memories and why you might prefer sad songs when you're feeling blue, but maybe you should resist the urge. We discuss Nick Cannon's recent narcissistic personality disorder diagnosis and how it's the least surprising diagnosis ever. We learn about the Glitter and Greed documentary about Lisa Frank, the woman and the business. And we consider why some of the best businesses, athletes, and artists are usually forged through cruel mentors, bosses, coaches and parents, and how we reconcile those things. Susie explains how menstrual cycles can affect athletes and make them more prone to injury, and how taking oral contraceptives has a dramatic effect on whether they get hurt. We hear about a man who was on death row longer than anyone else, and the fact that he was WRONGFULLY CONVICTED, and how it drove him insane.Listen to more podcasts like this: https://wavepodcastnetwork.comJoin our Candy Club, shop our merch, sign-up for our free newsletter, & more by visiting The Brain Candy Podcast website: https://www.thebraincandypodcast.comConnect with us on social media:BCP Instagram: https://www.instagram.com/braincandypodcastSusie's Instagram: https://www.instagram.com/susiemeisterSarah's Instagram: https://www.instagram.com/imsarahriceBCP on X: https://www.x.com/braincandypodSponsors:Visit https://cozyearth.com and use my exclusive 40% off code BRAINCANDY See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Taco Bout Fertility Tuesdays
Priming for IVF: Balancing Synchronization and Suppression

Taco Bout Fertility Tuesdays

Play Episode Listen Later Dec 11, 2024 17:25 Transcription Available


Send us a textToday, we dive into the world of IVF priming and uncover the delicate balance between synchronization and suppression. Learn how different priming methods like combined oral contraceptives, estrogen-only, progesterone-only, and cold starts play a pivotal role in setting the stage for successful outcomes. Whether you're curious about the science behind follicular development, concerned about over-suppression, or just looking for a deeper understanding of why your protocol was chosen, this episode has you covered. Join Dr. Mark Amols as he demystifies the strategies behind priming and helps you navigate this crucial step in your IVF journey.Thanks for tuning in to another episode of 'Taco Bout Fertility Tuesday' with Dr. Mark Amols. If you found this episode insightful, please share it with friends and family who might benefit from our discussion. Remember, your feedback is invaluable to us – leave us a review on Apple Podcasts, Spotify, or your preferred listening platform. Stay connected with us for updates and fertility tips – follow us on Facebook. For more resources and information, visit our website at www.NewDirectionFertility.com. Have a question or a topic you'd like us to cover? We'd love to hear from you! Reach out to us at TBFT@NewDirectionFertility.com. Join us next Tuesday for more discussions on fertility, where we blend medical expertise with a touch of humor to make complex topics accessible and engaging. Until then, keep the conversation going and remember: understanding your fertility is a journey we're on together.

Join the Docs
Pitch Perfect - Or Pitch Imperfect?

Join the Docs

Play Episode Listen Later Sep 17, 2024 21:02


Why do female singers sometimes sound like they've been gargling gravel? In this episode of Join the Docs, our melodious maestros, Professor Jonathan Sackier and Doctor Nigel Guest, strike a chord as they riddle on  raspy rappers and discuss distressed divas. Why might sopranos struggle to sing soulfully instead sometimes sounding far from sonorous? . They kick things off with a tuneful tour of the larynx and vocal cords, those tiny but mighty instruments that can make or break a performance. With a sprinkle of humour and a dash of puns, they explain how hormonal cycles can turn a diva's dulcet tones into a croaky chorus.Ever wondered why your favourite singer suddenly sounds like they've been shouting at a football match? The Docs delve into the various medical conditions that can cause hoarseness, from the common cold's pesky cousin, laryngitis, to the sneaky saboteur, acid reflux. They paint a vivid picture of how these ailments can transform a nightingale into a screech-owl, hooting away in distress. With anecdotes that hit all the right notes, they remind us that if hoarseness lingers longer than a three-week encore, it's time to seek medical advice.So, how do famous singers keep their voices in tip-top shape? The episode is peppered with references to iconic vocalists who have battled the dreaded hoarseness. Sackier and Guest serve up a smorgasbord of star-studded stories that add a touch of glamour to the medical mumbo-jumbo. Their witty banter and playful puns ensure that even the most complex concepts are as easy to swallow as a spoonful of honey.Is laughter really the best medicine? As the conversation crescendos, The Docs strike a perfect balance between education and entertainment. They sprinkle in just the right amount of humour, making the medical discussion as engaging as a front-row seat at a Broadway show.So, why not tune in and let Professor Jonathan Sackier and Doctor Nigel Guest serenade you with their insights on hoarseness? Thankfully without either of our two Docs bursting into song. Whether you're a singer, a fan, or just someone who loves a good laugh, this episode of Join the Dots hits all the high notes, ensuring you walk away with a smile on your face and a song in your heart.—--DISCLAIMER: The views and opinions expressed on Join the Docs are those of Dr. Nigel Guest, Jonathan Sackier and other people on our show. Be aware that Join the Docs is not intended to be medical advice, it is for information and entertainment purposes only - please, always take any health concerns to your doctor or other healthcare provider. We respect the privacy of patients and never identify individuals unless they have consented. We may change details, dates, place names and so on to protect privacy. Listening to Join the Docs, interacting on our social media, emailing or writing to us does not establish a doctor patient relationship.To Contact Us: For a deeper dive on this episode's issue, merchandise and exclusive content, head to www.jointhedocs.comFollow us on youtube.com/JoinTheDocs Follow us on instgram.com/JoinTheDocsFollow us on tiktok.com/JoinTheDocsFollow us on: facebok.com/JoinTheDocsFollow us on: x.com/JoinTheDocs

Ice Ice Beta
Training and Empowerment as a Female Athlete with Carolyn Parker

Ice Ice Beta

Play Episode Listen Later Jul 24, 2024 70:47


I'm sure Carolyn Parker could have become a household name if she had wanted. In her 20s and 30s, Carolyn was one of the most talented all-around mountain athletes in the U.S. — she was one of the first women to become an AMGA certified Rock Guide, climbed 5.12 trad at altitude

Practical Talks for Family Docs
BS Medicine Episode #575: Acne – the evidence for oral contraceptives and spironolactone

Practical Talks for Family Docs

Play Episode Listen Later Jun 19, 2024 25:57


In episode 575, James and Mike invite Jamie Falk back to the podcast to help us sift through all the evidence for using oral contraceptives and spironolactone to treat acne. We find that they actually do work. We go over all the numbers for the benefits and harms. Have a listen.   Show notes Tools for Practice Facing the Evidence in Acne, Part I: Oral contraceptives and spironolactone in females

Best Science Medicine Podcast - BS without the BS
Episode 575: Acne – the evidence for oral contraceptives and spironolactone

Best Science Medicine Podcast - BS without the BS

Play Episode Listen Later May 27, 2024 25:56


In episode 575, James and Mike invite Jamie Falk back to the podcast to help us sift through all the evidence for using oral contraceptives and spironolactone to treat acne. We find that they actually do work. We go over all the numbers for the benefits and harms. Have a listen. Show notes Tools for […]

Psychology Tidbits
ORAL CONTRACEPTIVES ASSOCIATED WITH DEPRESSION

Psychology Tidbits

Play Episode Listen Later Apr 14, 2024 1:54


The Maniculum Podcast
Valentine's Day Special: Magical and Medical Contraception

The Maniculum Podcast

Play Episode Listen Later Feb 17, 2024 107:19


Happy Valentine's Day! In this episode, we delve into medieval love spells, contraception, and the challenges women faced in matters of love and pregnancy. From mysterious plants and potions to debates among theologians on abortion ethics, explore the intersection of magic, societal views, and women's health in the Middle Ages. Join our discord community! Check out our Tumblr for even more! Support us on patreon! Check out our merch! The Beastiary Challenge! (

Medication Talk
Rx and OTC Oral Contraceptives

Medication Talk

Play Episode Listen Later Feb 1, 2024 34:25


Special guest Sarah E. Stumbar, MD, MPH, Assistant Dean for Clinical Education, Office of Medical Education and Associate Professor of Family Medicine, Department of Medical Education from the Herbert Wertheim College of Medicine, Florida International University joins us to talk about oral contraceptives.Listen in as our expert panel discusses safety and efficacy of combined oral contraceptives and progestin-only pills.  They'll also prepare you to help patients navigate norgestrel tablets, the first over the counter daily oral contraceptive.You'll also hear practical advice from panelists on TRC's Editorial Advisory Board:Stephen Carek, MD, CAQSM, DipABLM, Clinical Assistant Professor of Family Medicine, Prisma Health/USC-SOMG Family Medicine Residency Program at the USC School of Medicine GreenvilleCraig D. Williams, PharmD, FNLA, BCPS, Clinical Professor of Pharmacy Practice at the Oregon Health and Science UniversityNone of the speakers have anything to disclose. TRC Healthcare offers CE credit for this podcast. Log in to your Pharmacist's Letter or Prescriber Insights account and look for the title of this podcast in the list of available CE courses.The clinical resources mentioned during the podcast are part of a subscription to Pharmacist's Letter and Prescriber Insights: FAQ: Choosing a ContraceptiveChart: Comparison of Oral Contraceptives and Non-Oral Alternatives (United States)Chart: Comparison of Oral Contraceptives and Non-Oral Alternatives (Canada)If you're not yet a Pharmacist's Letter or Prescriber Insights subscriber, find out more about our product offerings at trchealthcare.com. Follow or subscribe, rate, and review this show in your favorite podcast app. You can also reach out to provide feedback or make suggestions by emailing us at ContactUs@trchealthcare.com.

Psychology Tidbits
ORAL CONTRACEPTIVES AND RISK OF DEPRESSION

Psychology Tidbits

Play Episode Listen Later Jan 9, 2024 2:30


Dr. Brendan McCarthy
Bioidentical Hormones vs Oral Contraceptives

Dr. Brendan McCarthy

Play Episode Listen Later Jan 1, 2024 14:47


Welcome to the podcast with Dr. Brendan McCarthy! Today's episode we discuss the differences between oral contraceptives and bio-identical hormone replacement therapy. May physicians do not explain the difference to their patients. This can lead to a lot of confusion and confusing dose effects. We hope this video gives you a better understanding of the difference, so when you find yourself needing to make a decision, you can ask the right questions, and get the best care. Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he's been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizona. A nationally recognized as an expert in hormone replacement therapy, Dr McCarthy s the only instructor in the nation who teaches BioHRT on live patients. Physicians travel to Arizona to take his course and integrate it into their own practices. Besides hormone replacement therapy, Dr. McCarthy has spoken nationally and locally before physicians on topics such as weight loss, infertility, nutritional therapy and more. Thank you for tuning in and don't forget to hit that SUBSCRIBE button! Let us know in the COMMENTS if you have any questions or what you may want Dr. McCarthy to talk about next! Check out Dr. Brendan McCarthy's Book! https://www.amazon.com/Jump-Off-Mood-Swing-Hormones/dp/0999649604 --More Links-- Instagram: www.instagram.com/drbrendanmccarthy TikTok: www.tiktok.com/drbrendanmccarthy Clinic Website: www.protealife.com

Emilia Thompson PhD
Episode 282. Dieting without binge eating, social anxiety & oral contraceptives

Emilia Thompson PhD

Play Episode Listen Later Dec 21, 2023 41:33


In this episode, Ros, Anna and Emilia answer client questions on alcohol & food for social anxiety, starting a diet after working through RWF issues, stopping overeating after work, protein oats, non negotiables for supporting fat loss without binge eating, going to bed hungry, learning the difference between boundaries & avoidance & oral contraceptives. For more information visit www.emilia.fitness or @ros_etphdcoaching @emiliathompsonphd @etphd_coaching @anna_etphdcoaching 

This Week In Wellness
TWIW 219: Oral Contraceptives may make women fearful

This Week In Wellness

Play Episode Listen Later Nov 12, 2023 5:14


This Week In Wellness a report published in Frontiers of Endocrinology has suggested that use of the Oral Contraceptive Pill may enhance women's susceptibility to stress-related illness and anxiety. https://www.news-medical.net/news/20231109/How-do-sex-hormones-and-birth-control-affect-brain-fear-circuits.aspx https://www.frontiersin.org/articles/10.3389/fendo.2023.1228504/full https://events.humanitix.com/de-stress-body-mind The post TWIW 219: Oral Contraceptives may make women fearful appeared first on The Wellness Couch.

Gillett Health
PMDD | The Gillett Health Podcast #44

Gillett Health

Play Episode Listen Later Sep 11, 2023 61:55


On today's podcast Dr. Gillett and James O'Hara NP, discuss Pre-Menstrual Dysphoric Disorder. They do a comprehensive "Non-Systematic Review". 00:00 Intro00:29 Differences in treatment for PMDD and sex offenders: explores the contrasting approaches to treating Premenstrual Dysphoric Disorder (PMDD) and sex offenders, highlighting how the two conditions require very similar treatment strategies.02:12 Non-systematic review of the evidence: analysis of research and evidence related to PMDD and sex offender treatment13:21 SSRIs: (SSRIs), a type of antidepressant medication, and their role in the treatment of PMDD or possibly other conditions.17:58 Oral Contraceptives: discusses the use of oral contraceptives as a treatment option for PMDD or related topics.19:24 "Treatments with strong scientific evidence": This segment may list and discuss various treatment options that have a claimed robust scientific basis for their effectiveness in addressing PMDD or other conditions.21:50 Same heading more aggressive treatments: This section might delve into treatment options that are considered more aggressive in addressing PMDD or similar conditions, potentially involving interventions beyond medication.23:52 Treatments with limited but promising evidence: We explore treatment approaches with limited scientific support but "promising" in managing PMDD or related issues.32:20 Closest to the root cause: We discuss treatments that aim to address the underlying causes or mechanisms of PMDD rather than just alleviating symptoms.40:41 Not effective: Treatments or approaches that have been found to be ineffective in managing PMDD or related conditions.44:55 Dutasteride study: A specific study or research involving the use of Dutasteride, a medication often used for enlarged prostate, and its potential effects on PMDD or a related topic.47:38 Low dose of Fluoxetine: The use of a low dose of Fluoxetine, an SSRI, in the context of PMDD or another condition.49:19 Effects of acute estradiol and progesterone/Suicidal: The effects of acute administration of estradiol and progesterone and their potential connection to suicidal tendencies or related issues.1:00:25 Outro:For High-quality labs:► https://gilletthealth.com/order-lab-panels/For information on the Gillett Health clinic, lab panels, and health coaching:► https://GillettHealth.comFollow Gillett Health for more content from James and Kyle► https://instagram.com/gilletthealth► https://www.tiktok.com/@gilletthealth► https://twitter.com/gilletthealth► https://www.facebook.com/gilletthealthFollow Kyle Gillett, MD► https://instagram.com/kylegillettmdFollow James O'Hara, NP► https://Instagram.com/jamesoharanpFor 10% off Gorilla Mind products including SIGMA: Use code “GH10”► https://gorillamind.com/For discounts on high-quality supplements►https://www.thorne.com/u/GillettHealth#podcast #womenshealth #hormones #female #women #gilletthealthAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

A Bit Better Every Day
The Pill's Effect on Your Hormones

A Bit Better Every Day

Play Episode Listen Later Aug 21, 2023 18:03


Understand how oral contraceptives affect your hormones, menstrual cycle, and long-term health. Connect with me on Instagram Enroll in Cycle Strategy 101 and learn to love your hormones! Beyond the Pill by Dr. Jolene Brighten

Emilia Thompson PhD
Episode 244. Oral contraceptives & training, alcohol & managing injuries.

Emilia Thompson PhD

Play Episode Listen Later Aug 3, 2023 56:00


In this episode, Bekka, Anna and Emilia answer client questions on bad coaching, journaling tips, starting to feel your feelings, oral contraceptives and training response, low cost gut health, imposter syndrome in job interviews, managing your relationship with alcohol, managing work stress, working in fitness without social media, mindset of injury and sharing your relationship with food journey with others.  For more information visit www.emilia.fitness or @emiliathompsonphd

Psychology Tidbits
ORAL CONTRACEPTIVES ASSOCIATED WITH DEPRESSION

Psychology Tidbits

Play Episode Listen Later Jun 19, 2023 1:54


Let's Talk About Women
Let's Talk About Oral Contraceptives

Let's Talk About Women

Play Episode Listen Later Jun 1, 2023 46:16


Welcome back to Let's Talk About Women! In this episode, PhD Student Franziska Weinmar is talking to Dr. Ann-Christin Kimmig about a hot topic: oral contraceptives. We cover the effects on hormone levels, the brain, mood, libido, and socio-emotional functions and what happens if you stop using the pill. Based on state-of-the-art research Ann-Christin and Franziska are trying to navigate and disentangle the importance of oral contraceptives, what has been disregarded in the past, what is known today – and what not. Also, we shed light on “the next big question” for research on oral contraceptives. Timestamps:00:00: Introduction01:16: History & importance of oral contraceptives03:55: (Neuro)biological mechanisms of oral contraceptives12:45: Effects of oral contraceptives on mood & socio-emotional functions25:13: Effects of stopping oral contraceptives32:02: Oral contraceptives & mental health38:20: Ann-Christin's "next big question" for future research42:38: Ann-Christin's wish & advice for women & health practitioners regarding oral contraceptivesSound recording & editing: Center for Media Competence, University of Tübingen. Do you have any feedback, suggestions, or questions? Get in touch with us: irtg2804.podcast@gmail.comAre you intrigued by this topic and want to be kept updated? Follow us on twitter: @irtg2804 or instagram: @irtg2804 Hosted on Acast. See acast.com/privacy for more information.

Womb Wealth + Wellness with Lauren Megan
023. The Ugly Truth of Behind Oral Contraceptives + The Copper IUD with Functional Medicine Practitioner Mireille Wagner

Womb Wealth + Wellness with Lauren Megan

Play Episode Listen Later May 29, 2023 49:43


In today's episode, Lauren sits down with functional medicine practitioner Mireille Wagner to have a super honest conversation around the state of women's health today. Lauren & Mireille talk about: >> What exactly is functional medicine and accessing the root of issues happening within the body >> Oral contraceptives and hormone health >> The copper IUD >> Minerals and why they are key to optimal health >> Vegan dieting vs eating animal protein   To work deeper with Lauren, please explore ways to work together below.   Connect with Lauren on Instagram: @iamlaurenmegan   Go Deeper: www.laurenmegan.com   Watch this episode on YouTube   About Mireille: After losing a dear friend to breast cancer, Mireille changed careers and made it her mission to learn about the root cause of disease and help educate others on the early signs and symptoms of chronic and autoimmune disease. Through education, inspiration and empowerment, she helps her clients change their lifestyle and nutrition habits one step at a time.   Check out Mireille's Bio here   You can follow Mireille on Instagram OR Facebook + watch more of her amazing content on her Youtube channel  

That Gym Girl
Your period is affecting your results in the gym! How's Why!

That Gym Girl

Play Episode Listen Later May 12, 2023 27:40


Hey sis, welcome back to another juicy episode of That Gym Girl Podcast. Today, I am back at you with another menstrual cycle episode! We are breaking down how the menstrual cycle works and how you should train in according to this! And lemme tell you, this is NOT one to miss!LET'S JUMP ON A 1:1 CALL TO CHAT ABOUT YOUR TRAINING & FITNESS, book in herePURCHASE YOUR TICKET TO OUR LONDON EVENT HEREThe following topics are discussed in today's episode:My opinion on evidence & researchMenstrual cyclesMenstrual phaseFollicular phaseOvulatory phaseLuteal phaseImpact of menstrual cycle on lifting weightsThe contraceptive pillMy experience on the pillResearch I refer:Effects of Follicular and Luteal Phase-Based Menstrual Cycle Resistance Training on Muscle Strength and MassEffects on power, strength and lean body mass of menstrual/oral contraceptive cycle based resistance trainingThe Effect of the Menstrual Cycle and Oral Contraceptives on Acute Responses and Chronic Adaptations to Resistance Training: A Systematic Review of the LiteratureUse code THATGYMGIRL for some $$ off at Naked Harvest hereJoin That Gym Girl private Facebook group hereIf you love the poddy, you should check out my socials:Instagram: @angelwallacemiles - click hereInstagram: @thatgymgirlpodcast - click hereTik Tok: @angelwallacemilesHave the most fabulous day! And make sure to do something for yourself, you deserve it.With love always,Angel. Xo Become a member at https://plus.acast.com/s/that-gym-girl. Hosted on Acast. See acast.com/privacy for more information.

Pro-Life America
Episode 138 | What The Abortion Industry Doesn't Want You To Know About Repeat Abortions

Pro-Life America

Play Episode Listen Later Apr 6, 2023 16:56


Are repeat abortions only a tiny fraction of the abortion rate? Are teens having multiple abortions? Does having multiple abortions impact a woman's health? Is more contraception the answer? We answer all this and more in an episode revealing the truth about repeat abortion - and its effects - that the abortion industry can't afford for people to hear. Topics Discussed:YouTube pulls an episode of LifeTalk?!The rates of repeat abortionsRepeat Abortion & TeensRepeat abortion and contraceptionThe impact of repeat abortions on healthOther effects of repeat abortions Links Mentioned: Episode 64 of LifeTalk on FacebookRepeat Abortion, Repeat Unintended Pregnancy, Repeated and Misguided Government Policies - Guttmacher InstituteHow common are repeat abortions? - NICS WellWhich Abortion Patients Have Had a Prior Abortion? Findings from the 2014 U.S. Abortion Patient Survey - NIHAbortions: Five teenagers among women who had at least their 6th termination in UK last year - SkyNewsNew Study: Rapid Repeat Pregnancy Most Common Among Women Who Have Abortions - Charlotte Lozier InstituteLikelihood of repeat abortion in a Swedish cohort according to the choice of post-abortion contraception: a longitudinal study - AOGSRepeat abortions linked to premature birth, study suggests - BBC NewsHaving three or more abortions 'raises risk of premature birth and life-threatening problems in future pregnancies' - Daily MailBook: Women's Health After Abortion: The Medical and Psychological EvidenceRepeated abortion in adulthood induces cognition impairment in aged mice - nature.comNHS spends £1m a week on repeat abortions: Single women using terminations 'as another form of contraceptive' - Daily MailRate & Review Our Podcast Have a topic you want to see discussed on the show? [Submit it here.]To learn more about what Life Dynamics does, visit: https://lifedynamics.com/about-us/Support Our Work 

DUTCH Podcast
Oral Contraceptives: the Good, the Bad, and the Ugly with Rebecca Clemson, ND

DUTCH Podcast

Play Episode Listen Later Feb 28, 2023 35:11


Oral contraceptive pills (OCPs), or “the pill,” revolutionized women's healthcare in 1950. Now, almost 75 years later, women and their practitioners are asking questions. In this thought-provoking episode of the DUTCH Podcast, Dr. Jaclyn Smeaton and Dr. Rebecca Clemson compare and contrast the usefulness of the pill with some of its side effects.  You can join the conversation on the good and bad of birth control. Listen now! Sections and Timestamps 00:00Intro 04:10The pill to “fix” female problems 08:02Uses for the pill 12:10The pill is not benign 18:20Cardiovascular risks and the pill 19:56When should a patient take an OCP? 24:50Endometriosis and OCPs 27:41How to do birth control right 34:15Conclusion

Run4PRs
192. How fast should you run on race day? & more ask the coaches questions

Run4PRs

Play Episode Listen Later Feb 16, 2023 58:43


1 .What pace should I am to race at for a 5k or half marathon? Threshold? Intervals? Slightly slower? Slightly faster? Answer: if you download our guide at www.run4prs.com it will go over this in great detail written out. We will summarize here. First, it's important to do a fitness test. This fitness test usually looks like a time trial of running 1-3 miles ‘all out effort' to see where your current fitness is at. If you have absolutely no idea where your fitness is at, start at a pace 30-45 seconds faster than you run on a good ‘moderate/harder' effort run. We can't establish paces without first understanding where you are at currently. If you totally bomb the time trial, that is okay, we can always test again. The result will still be a good guide within reason. Your 5k pace is usually the same (slightly slower) than your time trial pace. Intervals are going to be done anywhere from slightly faster than 5k pace to threshold pace.. It depends on the purpose of the workout Your threshold pace is about 20-30 seconds per mile slower than time trial pace Your half marathon pace is 5-20 seconds per mile slower than threshold pace Whenever we do an event for the first time or even if it's the 5th time, but you feel newer to racing, we might not go out at that exact pace I said above. We might want to ease into things and start slower. We build confidence by having positive racing experiences. 2. What are the worst things to eat before a long run? Depends on the person. The worst thing you can probably do is not eat. Next, anything with insanely high fiber content. Like multiple fiber one bars. Spicy foods, etc. Some people have very strong stomachs and could literally tolerate anything. I have a friend who can't eat veggie straws the day before a run. Knowing your body is key! Usually they say to avoid fiber and greasy foods. Also if you have food intolerances, avoid that! 3. What are the effects of birth control on female runner performance I would look into the book roar by Tracy Sims. Anytime you take synthetic hormones, you are changing systems in the body. There can be some benefits to taking birth control, but are there some drawbacks? I think it's important for people to do their research and have this discussion with their doctors. https://pubmed.ncbi.nlm.nih.gov/32666247/ Oct 2020: The Effects of Oral Contraceptives on Exercise Performance in Women: A Systematic Review and Meta-analysis Conclusions: OCP use might result in slightly inferior exercise performance on average when compared to naturally menstruating women, although any group-level effect is most likely to be trivial. Practically, as effects tended to be trivial and variable across studies, the current evidence does not warrant general guidance on OCP use compared with non-use. Therefore, when exercise performance is a priority, an individualised approach might be more appropriate. The analysis also indicated that exercise performance was consistent across the OCP cycle. What exercises/workouts/circuits can I incorporate in the gym to help my running? Running is going to be the best thing you can do that directly makes you a better runner. Other workouts the strengthen the endurance of the muscles that are used for running can help but nothing helps as much as running. Biking, stairs, etc. Why do runners lift then? Strength training can help you stay injury free. The longer you are able to stay injury free, the better you will be able to run consistently. Runners need: Postural alignment, stabilization, strength and power Train for strength 8-12 reps

Podcast Notes Playlist: Latest Episodes
Dr. Sara Gottfried: How to Optimize Female Hormone Health for Vitality & Longevity

Podcast Notes Playlist: Latest Episodes

Play Episode Listen Later Feb 3, 2023 155:04


Huberman Lab Podcast Notes Key Takeaways “Being female is a health hazard; we have twice the rate of depression, insomnia, we've got 3-4x increased risk of multiple sclerosis, we've got 5-8x the risk of thyroid dysfunction.” – Dr. Sara GottfriedMainstream medicine is still silo-based; as long as this is true, there's very little collaboration and addressing of network effectDo blood work as soon as possible! Knowing & monitoring your bloodwork may change the arc of how you take care of yourself Continuous glucose monitors are an excellent way to learn about yourself and address behavior changes – it teaches the patient to be their own physicianTo maximize vitality and longevity: sleep, avoid excessive alcohol, address perceived stress, be mindful of eating well, avoid toxic relationships, move intentionally in ways that work for your bodyRanking most useful supplements for the general population (but remember, start with high-quality food first): fish oil, magnesium, vitamin DExercise tips: balance routine to 1/3 cardio + 2/3 strength training Note, high levels of cardio can increase cortisol levels!Early hormone replacement therapy should be strongly considered! The decline in estrogen which starts around 40-43 seems to be the driver behind cerebral hypometabolism (decline in brain function) “Hot flashes and night sweats are a biomarker of cardiometabolic disease – they are a biomarker of increased bone loss, they are a biomarker of changes in the brain. So many of the symptoms that occur in peri-menopause are not driven by the ovaries, they're driven by the brain.” – Dr. Sara GottfriedRead the full notes @ podcastnotes.orgMy guest is Sara Gottfried, M.D., a Harvard-trained, board-certified gynecologist and clinical assistant professor of integrative medicine & nutritional sciences at Thomas Jefferson University. Dr. Gottfried specializes in hormone health, vitality and longevity using precision/personalized approaches. We discuss female hormone health, puberty, perimenopause, and menopause, hormone testing, the microbiome, stress related hormone challenges, their causes, and various treatments. We also discuss fertility, birth control and tools for improving microbiome health, treating PCOS, insulin management, and the best nutrition, supplementation, and exercise programs for women. While the episode focuses mainly on female hormones, males will also  benefit from our discussion because it includes  actionable tools suggested for managing stress, bolstering the gut microbiome, and immunity—all of which stand to improve overall health, vitality and longevity in males and females. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman ROKA: https://roka.com/huberman Thesis: https://takethesis.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. Sara Gottfried (00:03:51) ROKA, Thesis, LMNT, Momentous (00:07:50) Women, Family History, Heredity & Environment (00:11:00) Puberty, Stress, Menstrual Cycles, Intrauterine Devices (IUDs) (00:17:26) Tool: Sex Hormones, Microbiome, Estrobolome & Disease; Biomarker Testing (00:25:11) Nutritional Testing; Vegetables, Microbiome & Disease (00:31:13) AG1 (Athletic Greens) (00:32:22) Microbiome, Prebiotics & Probiotics, Inflammation (00:36:08) Microbiome Testing, Magnesium, Constipation & Thyroid (00:42:25) Female Colonoscopy; Network Effect & Modern Medicine, Stress Factors (00:45:13) Constipation, Stress & Trauma, Autonomic Balance (00:55:35) Constipation Relief, Stress, Breathwork & Meditation (01:02:58) Systemic & Societal Stress Unique to Females (01:08:19) InsideTracker (01:09:23) Testing & Future Behavior (01:11:55) Polycystic Ovary Syndrome (PCOS) & Cardiometabolic Disease; Stress  (01:22:57) PCOS, Insulin, Glucose Monitoring and Management; Data Access (01:29:48) Behaviors for Vitality; Exercise & Body Phenotype; Cortisol (01:36:40) Cortisol Supplements: Ashwagandha, Rhodiola, Fish Oil, Phosphatidylserine (01:42:36) Cortisol, Anxiety & Immune System; Adrenal Function, Resilience (01:48:07) Tool: Omega-3 Fatty Acids, Inflammation, Specialized Pro-Resolving Mediators (01:54:20) Oral Contraceptives, Benefits & Risks; Ovarian Cancer; Testosterone (02:06:50) Fertility, Follicular & Anti-Mullerian Hormone (AMH) Assessments (02:10:29) Menopause & Hormone Replacement Therapy; Women's Health Initiative (02:15:30) Perimenopause, Cerebral Hypometabolism, Metabolism & Estrogen (02:21:49) Intermittent Fasting, Ketogenic Diet, Metabolic Flexibility  (02:23:29) Stool Testing (02:25:32) Coronary Artery Calcium (CAC) Test, ACE Score & Disease  (02:31:56) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Neural Network Newsletter, Momentous Title Card Photo Credit: Mike Blabac Disclaimer

Huberman Lab
Dr. Sara Gottfried: How to Optimize Female Hormone Health for Vitality & Longevity

Huberman Lab

Play Episode Listen Later Jan 30, 2023 155:04 Very Popular


My guest is Sara Gottfried, M.D., a Harvard-trained, board-certified gynecologist and clinical assistant professor of integrative medicine & nutritional sciences at Thomas Jefferson University. Dr. Gottfried specializes in hormone health, vitality and longevity using precision/personalized approaches. We discuss female hormone health, puberty, perimenopause, and menopause, hormone testing, the microbiome, stress related hormone challenges, their causes, and various treatments. We also discuss fertility, birth control and tools for improving microbiome health, treating PCOS, insulin management, and the best nutrition, supplementation, and exercise programs for women. While the episode focuses mainly on female hormones, males will also  benefit from our discussion because it includes  actionable tools suggested for managing stress, bolstering the gut microbiome, and immunity—all of which stand to improve overall health, vitality and longevity in males and females. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman ROKA: https://roka.com/huberman Thesis: https://takethesis.com/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. Sara Gottfried (00:03:51) ROKA, Thesis, LMNT, Momentous (00:07:50) Women, Family History, Heredity & Environment (00:11:00) Puberty, Stress, Menstrual Cycles, Intrauterine Devices (IUDs) (00:17:26) Tool: Sex Hormones, Microbiome, Estrobolome & Disease; Biomarker Testing (00:25:11) Nutritional Testing; Vegetables, Microbiome & Disease (00:31:13) AG1 (Athletic Greens) (00:32:22) Microbiome, Prebiotics & Probiotics, Inflammation (00:36:08) Microbiome Testing, Magnesium, Constipation & Thyroid (00:42:25) Female Colonoscopy; Network Effect & Modern Medicine, Stress Factors (00:45:13) Constipation, Stress & Trauma, Autonomic Balance (00:55:35) Constipation Relief, Stress, Breathwork & Meditation (01:02:58) Systemic & Societal Stress Unique to Females (01:08:19) InsideTracker (01:09:23) Testing & Future Behavior (01:11:55) Polycystic Ovary Syndrome (PCOS) & Cardiometabolic Disease; Stress  (01:22:57) PCOS, Insulin, Glucose Monitoring and Management; Data Access (01:29:48) Behaviors for Vitality; Exercise & Body Phenotype; Cortisol (01:36:40) Cortisol Supplements: Ashwagandha, Rhodiola, Fish Oil, Phosphatidylserine (01:42:36) Cortisol, Anxiety & Immune System; Adrenal Function, Resilience (01:48:07) Tool: Omega-3 Fatty Acids, Inflammation, Specialized Pro-Resolving Mediators (01:54:20) Oral Contraceptives, Benefits & Risks; Ovarian Cancer; Testosterone (02:06:50) Fertility, Follicular & Anti-Mullerian Hormone (AMH) Assessments (02:10:29) Menopause & Hormone Replacement Therapy; Women's Health Initiative (02:15:30) Perimenopause, Cerebral Hypometabolism, Metabolism & Estrogen (02:21:49) Intermittent Fasting, Ketogenic Diet, Metabolic Flexibility  (02:23:29) Stool Testing (02:25:32) Coronary Artery Calcium (CAC) Test, ACE Score & Disease  (02:31:56) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Neural Network Newsletter, Momentous Title Card Photo Credit: Mike Blabac Disclaimer

SYNC Your Life Podcast
Gaslighting in Women's Health

SYNC Your Life Podcast

Play Episode Listen Later Jan 17, 2023 24:34


Welcome to the SYNC Your Life podcast episode #108! On this podcast, we will be diving into all things women's hormones to help you learn how to live in alignment with your female physiology. Too many women are living with their check engine lights flashing. You know you feel "off" but no matter what you do, you can't seem to have the energy, or lose the weight, or feel your best. This podcast exists to shed light on the important topic of healthy hormones and cycle syncing, to help you gain maximum energy in your life.  In today's episode, I'm shedding light on the topic of gaslighting in women's health. I dive into what gaslighting is, how it's keeping many women from uncovering their root causes, and what the alternatives are to this unfortunate wide-spread problem.  In this episode, I refer to episode #1 of the podcast, My Story, found here. I also refer to the previous episode, The Overprescribedness of Oral Contraceptives, found here. In addition, I refer to this article written by Dr. Lara Briden on "How Birth Control Switches Off Hormones and Why It Matters." The Business of Birth Control documentary can be found here. You can learn more about a functional approach by tuning into various video interviews in my Virtual Summit, found here. Obtain $100 off your DUTCH test by visiting: Dutchtest.com/patients And use the unique code: jsl100 If you feel like something is "off" with your hormones, check out the FREE hormone imbalance quiz at sync.jennyswisher.com.  To learn more about the SYNC Digital Course, check out jennyswisher.com.  Let's be friends outside of the podcast! Send me a message or schedule a call so I can get to know you better. You can reach out at https://jennyswisher.com/contact-2/. Enjoy the show! Episode Webpage: jennyswisher.com/podcast 

Science of Getting Faster Podcast - Presented by TrainerRoad
Do Birth Control Pills Make You Slower? w/ Dr. Kelly McNulty - Science of Getting Faster Ep.10

Science of Getting Faster Podcast - Presented by TrainerRoad

Play Episode Listen Later Dec 28, 2022 51:03


Almost half of elite female athletes are hormonal contraceptive users. But do we know the impact they have on performance? Dr. McNulty joins us to shed light on this enigmatic topic in exercise physiology. In this episode of the Science of Getting Faster Podcast, Dr. McNulty outlines our contraceptive options, what these contraceptives are made up of, and how they impact our natural hormonal environment. Ultimately, this episode helps women and their coaches make informed decisions as it relates to their physiology and performance.   FOLLOW DR. MCNULTY: Instagram: @periodoftheperiod Twitter: @kellymcnulty RESOURCES FROM THIS EPISODE: https://trainerroad.cc/3Gortad TOPICS COVERED IN THIS EPISODE:  (0:50) Different types of contraceptives available to women (9:28) Most commonly used hormonal contraceptive and prevalence in the athletic population (10:43) Why do the athletic population (14:00) How the oral contraceptive pills impact a women's natural hormonal environment? (19:30) Is the withdrawal bleed that is experienced on the oral contraceptive pill equivalent to natural menstrual bleeding? Why is this important to keep in mind in the athletic population? (20:30) Are there risks to chronic down regulation of a women's own endogenous hormones, via the oral contraceptive pill? (21:32) How do our different sex hormones impact exercise physiology? (24:58) Is our exercise performance impacted by the phase of the menstrual cycle? (31:08) What comparisons were made to determine the impact of Oral Contraceptives on performance? (37:05) The results!  (40:40) What does Dr. McNulty recommend for finding a hormonal birth control that works well for you? (46:40) Does the oral contraceptive pill impact strength and endurance performance differently? (47:30) What research is missing on female athletes? • Continue the discussion on the TrainerRoad Forum: https://trainerroad.cc/3LvmBRn  • Submit a study, researcher or topic to be covered on the Science of Getting Faster Podcast: https://www.TrainerRoad.com/SOGF  ABOUT TRAINERROAD — CYCLING'S MOST EFFECTIVE TRAINING SYSTEM TrainerRoad makes cyclists faster. Athletes get structured indoor workouts, science-backed training plans, and easy-to-use performance analysis tools to reach their goals • Introducing Adaptive Training: https://bit.ly/3qb8KDn  • Build Your Custom Plan: https://bit.ly/3rbc0jM  • Train Together with Group Workouts: https://bit.ly/3r8PRlQ   • Get Started: https://bit.ly/302vUkW  SCIENCE OF GETTING FASTER PODCAST The Science of getting Faster Podcast cuts through the noise and talks directly to the scientists doing the latest research into how to become a faster cyclist, stronger athlete, and healthier person. Join Sarah Laverty of TrainerRoad as she interviews a new researcher every month about their latest studies, what questions they were hoping to answer, what they observed and what they are still hoping to learn.  • Subscribe to the Science of Getting Faster Podcast on iTunes: https://www.TrainerRoad.com/SOGF  FOLLOW TRAINERROAD • Facebook: https://www.facebook.com/TrainerRd     • Instagram: https://www.instagram.com/trainerroad/   • Twitter: https://twitter.com/TrainerRoad  • Strava Club: https://www.strava.com/clubs/trainerroad

Practical Talks for Family Docs
BS Medicine Episode #519: Oh Baby – Combined oral contraceptives during breastfeeding

Practical Talks for Family Docs

Play Episode Listen Later Dec 7, 2022 26:59


To claim your Mainpro+ credit click on link below: https://cfpclearn.ca/podcast/bs-medicine-episode-519-oh-baby-combined-oral-contraceptives-during-breastfeeding/ In episode 519, Mike and James ask Jen Potter back to the podcast to talk about a common primary care question around oral contraceptives and breast feeding. We review the best available evidence which unfortunately we find out is not the highest quality. Nonetheless, we go over the numbers and then come up with useful, hopefully, suggestions for what to do around this issue.

Eric Bakker - The Naturopath
Candida and Oral Contraceptives | 1 min Candida Q&A | CanXida Your Gut Health Podcast

Eric Bakker - The Naturopath

Play Episode Listen Later Oct 31, 2022 1:30


Candida and Oral Contraceptives | 1 min Candida Q&A | CanXida Your Gut Health Podcast Your most burning questions on candida answered in bite-size content. You'll get practical tips that you can follow right away to improve your life. ► FREE RESOURCES: Download our free candida report here (includes the Ultimate Candida Diet Shopping List Printable and the Candida Symptom Tracker): https://bit.ly/3u7LdqR Candida Diet & Cleanse Guide Mobile App: IOS: https://apple.co/2W7RC8G Android: https://bit.ly/3CAsaZc Breathing App on Chrome Web Store: https://bit.ly/3s0ztE0 Our Blog: https://www.yeastinfection.org Our Weekly newsletter: https://bit.ly/39xMVIq ► OTHER RESOURCES: Candida Diet Cleanse And Detox Planner: https://amzn.to/3C9lH7u Bestselling book: https://www.candidacrusher.com/ Our line of supplements: https://www.canxida.com/ ► FOLLOW US: Facebook: https://bit.ly/3eGS1Iq Pinterest: https://pin.it/nCWiVZB YouTube: https://bit.ly/3goHEth Instagram: https://bit.ly/3DdnZFZ TikTok: https://bit.ly/3TyIge9 ► GET IN TOUCH WITH US: https://www.canxida.com/contact/ Please Subscribe, Like, Share and Comment. * PLEASE READ: If you or someone you know is in immediate danger, please call a local emergency telephone number or go immediately to the nearest emergency room.

Stroke Alert
Stroke Alert October 2022

Stroke Alert

Play Episode Listen Later Oct 20, 2022 41:00 Very Popular


On Episode 21 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2022 issue of Stroke: “Oral Contraceptives, Hormone Replacement Therapy, and Stroke Risk” and “Effectiveness and Safety of Antithrombotic Medication in Patients With Atrial Fibrillation and Intracranial Hemorrhage.” She also interviews Dr. Shadi Yaghi about his article “Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis.” Dr. Negar Asdaghi:         Let's start with some questions. 1) Do hormone replacement therapies or oral contraceptives increase the risk of stroke? And if yes, does the age of the individual or the duration of therapy modify this risk? 2) Should survivors of intracranial hemorrhage who have atrial fibrillation be treated with antithrombotic therapies for secondary prevention of stroke? 3) And finally, what is the anticoagulant of choice for treatment of cerebral venous sinus thrombosis? We have the answers and much more in today's podcast as we continue to bring you the latest in cerebrovascular disorders. You're listening to the Stroke Alert Podcast, and this is the best in Stroke. Stay with us. Welcome back to another amazing issue of the Stroke Alert Podcast. My name is Negar Asdaghi. I'm an Associate Professor of Neurology at the University of Miami Miller School of Medicine, and your host for the monthly Stroke Alert Podcast. The October issue of Stroke covers a number of timely topics. As part of our October Literature Synopsis, we have a nice paper by Dr. Farida Sohrabji and colleague, which summarizes three recently published animal studies to evaluate the association between small vessel ischemic injury and either development of Parkinsonism or the future risk of Parkinson's disease. These studies looked at how ischemia, specifically involving the lenticulostriate arteries, can modulate the nigrostriatal dopaminergic pathway and ultimately lead to Parkinsonism. As part of our Original Contributions, we have the results of a small randomized trial out of Korea, which was led by Dr. Yun-Hee Kim from Sungkyunkwan University School of Medicine in Seoul, where we learned that doing 20 sessions of transcranial direct current stimulation for about 30 minutes for each session at home can improve post-stroke cognition. This was found to be specifically effective in patients with post-stroke moderate cognitive decline. Now, transcranial current stimulation can be given using a handheld device at home, and if truly proven safe and efficacious in larger studies, can dramatically change the landscape of stroke recovery in cognitive rehabilitation. I encourage you to review these articles in addition to listening to our podcast today. Later in the podcast, I have the great pleasure of interviewing Dr. Shadi Yaghi from Brown University. Shadi will walk us through a systematic review and meta-analysis of published studies to compare the safety and efficacy of direct oral anticoagulants to that of vitamin K antagonists in patients with cerebral venous sinus thrombosis. Our devoted Stroke Alert Podcast listeners recall that we did cover this topic in our March podcast when we reviewed the results of ACTION-CVT, a multicenter international study that was led by none other than Shadi himself. I'm delighted to have him as a guest on my podcast today to talk more about the seminal study and all things cerebral venous sinus thrombosis. But first, with these two articles. Millions of women worldwide use exogenous hormones, most commonly in the form of oral contraceptives and hormone replacement therapies. Despite the many different formulations of these drugs that are now available on the market, the two therapies are similar in that both combined oral contraceptives and hormone replacement therapies, or HRTs, contain various dosage of estrogen and progestin. Now, the principal difference between them being that the hormone contents of oral contraceptives are at high enough dosage to prevent ovulation, whereas hormone replacement therapies are considered more physiological as their aim is to return post-menopausal hormone levels to what they were before menopause. Well, by now, you must wonder how is any of this even relevant to vascular neurology? Well, the answer lies in the close relationship between hormonal therapies and stroke. But before we get to that, we have to review a few things. First of all, it's long been known that the endogenous estrogen has strong and protective effects on the arteries. It promotes vasodilation and cell survival of the endothelial layer. It increases the endothelial mitochondrial efficiency and stimulates angiogenesis. In other words, endogenous estrogen is good for vascular health. And in fact, that's why we think that premenopausal women, in general, are at a lower risk of stroke as compared to their age and vascular risk factors–matched male counterparts. And to make things even better for estrogen, there's enough evidence to suggest that exogenous estrogen also does all of these good things for the endothelium. So, why are we even talking about an increased risk of stroke associated with use of hormonal therapies? The problem is, we have to remember that exogenous estrogen also does other things. It can increase the blood concentration of procoagulants, which, in turn, can increase the risk of thromboembolism, especially venous thrombosis. But there's still a lot of unknown on this topic. For instance, the majority of the prior research on the topic involves postmenopausal women using hormonal therapies. Some of that research has actually suggested that HRTs may be protective against vascular events, while others showed the opposite. Well, we know that a majority of oral contraceptive users are actually much younger and use these medications premenopausal. So, there seems to be a lot of gaps in our current knowledge on the simple question of whether or not oral contraceptives and hormonal replacement therapies do, in fact, increase the risk of stroke or not. In the current issue of the journal, a group of researchers led by Drs. Therese Johansson, Torgny Karlsson, and Åsa Johansson from the Department of Immunology, Genetics and Pathology at Uppsala University in Sweden set out to fill some of these gaps with their study titled, "Oral Contraceptives, Hormone Replacement Therapy, and Risk of Stroke," as part of a large UK Biobank population-based cohort. Just a bit about the UK Biobank. This was a large population-based cohort from 2006 to 2010 that included over 500,000 residents of the United Kingdom between the ages of 37 and 73. Participants at the time of enrollment would have extensive information collected from them through questionnaires, interviews, health records, physical measures, as well as some imaging and biological samples. Data on each participant was collected from the time of their birth all the way to the day of assessment, which is interesting, because the day of assessment would then count as the end of the follow-up for each participant. Now, for the current study, they included over 250,000 women of White race in whom information required for the study on whether or not they use hormonal therapies, duration of treatment, age at the time of exposure was available. And just a quick comment about their methodology. They analyzed their cohort once for oral contraceptive use and once for HRT use and compared each group to a reference group of either women who never used their set therapy or the number of years they contributed to the study prior to initiating that set treatment. So, for instance, if a person started using oral contraceptives at the age of 21, all of the years that she contributed to the study before that age would count as non-exposed user years and were included in the control cohort. So now, on to their findings. A total of 3007 stroke diagnosis of any type were identified prior to the initial visit to the assessment center, which, as we mentioned, was the end of the follow-up in the study. Of these, 578 were ischemic strokes, 177 intracerebral hemorrhage, and 478 were subarachnoid hemorrhages. But as expected for any large cohort, over half of total strokes were self-reported as stroke of any type and could not be classified into any of the above subtypes. Now, let's look at the effects of oral contraceptives on the outcome of stroke. Overall of the women included in the study, 81% were classified as oral contraceptive users, while 19% reported never having used oral contraceptives at any point during the study. On the association between oral contraceptive use and the risk of stroke, at first glance, things looked OK. The hazard rates of any stroke for any stroke subtypes were not different between women who had used oral contraceptives as compared to those in the reference group. That's great news. But when they looked deeper, they realized that the odds of development of any stroke was actually quite high during the first year after the initiation of oral contraceptives with hazard rate of 2.49 for any stroke, while there was no difference in hazard rates found during the remaining years of use and after discontinuation of oral contraceptive use. So, meaning that there was no lingering effects of oral contraceptives on increased risk of stroke after the first year or after discontinuing the medication. Now, on to HRTs. In total, 37% of women in the study had initiated HRTs at some point during the study, while 63% had never used this therapy. Here's the bad news. Overall, HRTs did increase the risk of stroke. An approximately 20% increase event rate of any stroke was noted among women who had initiated HRTs as compared to those who had not. When analyzing stroke subtypes, the use of HRTs was associated with increased risk of only the subarachnoid hemorrhage subtypes. We don't know why. Diving deeper, in considering timing of HRT initiation, very similar to what was observed for the oral contraceptives, during the first year after starting the HRTs, the treatment group was twice more likely to suffer from any type of stroke, and the hazard rate was also increased for all three stroke subtypes that were available in the study. But, unlike oral contraceptives, the hazard rate of any stroke remains significantly high even after the first year of use, not just for those who continued HRTs, but sadly, even for those who discontinued the therapy. Though the risk remained high, the hazard ratio declined over time as we went further away from the first year when treatment was initiated. So, bottom line, if women had initiated HRTs at some point in their life, the hazard risk of any stroke increased significantly in the first year. That hazard risk did decline over time, but it always remained significantly higher than non–HRT users. Now, what about timing of treatment in relation to the onset of menopause? Is the risk of stroke any different if women start on HRTs prior to or after their menopause? The answer is no. Initiation of HRTs was associated with an increased hazard rate of any stroke if it was started pre- or postmenopausal, but the risks were higher if the treatment was started prior to menopause. So, in summary, this large population-based cohort has truly given us some very important practical findings. We learned that both oral contraceptives and hormone replacement therapies do, in fact, increase the risk of stroke, an effect that was most notable in this study in the first year after initiation of both of these therapies, and in the case of oral contraceptives, was just actually limited to that one year alone. Why does this happen? I guess the easy answer is that these drugs, as we noted earlier, have an immediate prothrombotic effect, which gradually weakens over time. That's one plausible explanation, but for instance, why HRTs increase the risk of subarachnoid hemorrhage is something we can't explain based on the prothrombotic effects of HRTs. So, we have to come back to the vessels, the impact of hormone therapies and estrogen specifically on the blood vessels, on the endothelial cells, the potential increase in blood pressure, especially early on in the course of treatment with these medications. And also, we have to think about the role these drugs may play in increasing inflammatory markers, providing a more suitable milieu for accelerated atherosclerosis, as to why these associations were noted in this study. And it's fair to say that we need more research on this topic in the future. One challenging scenario that we commonly face in our daily practice is deciding whether or not we should resume antithrombotics in patients with atrial fibrillation who have survived an intracranial hemorrhage. The majority of intracranial hemorrhage survivors with atrial fibrillation actually have a very high CHA2DS2-VASc score, which means that they are actually at a very high risk of future ischemic stroke and systemic embolic events unless they're treated with anticoagulants. On the other hand, the risk of spontaneous intracranial bleeding is substantially higher in a person who has previously suffered from one, let alone if we treat them with anticoagulants. And to make matters worse, we have little evidence from the literature to guide us. So, in the current issue of the journal, in the study titled "Effectiveness and Safety of Antithrombotic Medication in Patients With Atrial Fibrillation and Intracranial Hemorrhage," a group of researchers from the UK led by Dr. Deirdre Lane, Professor of Medicine at the University of Liverpool, performed a much needed systematic review and meta-analysis of the available evidence on this subject. I have to say that lately, it seems that we've been covering a few of these reviews in our podcasts, and we are just getting started. In fact, my next paper in today's episode is also a systematic review and meta-analysis. These papers are packed with details, a testament to the work needed to complete them, but I have to say that even summarizing these papers for a podcast has been a bit challenging. So, feel free to put me on pause, go get some coffee, and let's power through this one together. For their methods, they used the usual search engines looking for papers that included adults over the age of 18 with atrial fibrillation who had survived a non-traumatic spontaneous intracranial hemorrhage of any size, any type, and any location, be it lobar, brain stem, deep, cerebellar, subdural, epidural, or subarachnoid hemorrhage. And very importantly, they included even those with evidence of microbleeds on neuroimaging. The intervention of interest was either long-term oral anticoagulation or antiplatelet therapy versus no antithrombotic use for the following three outcomes of interest: number one, recurrent thromboembolic events; number two, recurrent intracranial hemorrhage; and number three, all-cause mortality. Just a quick note that for this analysis, they excluded studies that looked at either short-term anticoagulation or non-oral anticoagulation use for any reason that was given to the patient other than for secondary prevention of stroke. For example, if a patient suffered from a pulmonary embolism and was treated with IV heparin or, for a short period of time after that, with oral anticoagulation, those patients or those studies were excluded from this meta-analysis. So, with this criteria, they pulled over 4,000 citations and abstracts, and finally included 20 papers that were published between 2015 and 2021 for a total of over 50,000 participants for this meta-analysis, very nice sample size. Most of the papers included were observational cohorts, but in addition, we had two small randomized trials, and I want to take a moment and review these trials for our listeners. The first one was a small noninferiority pilot trial out of the UK, the SoSTART trial, that looked at any anticoagulant versus either antiplatelet therapy or no antithrombotics in this population, and the other trial was the Phase 2 trial, the APACHE-AF, that studied apixaban versus no anticoagulation after anticoagulant-associated intracerebral hemorrhage. A reminder that both of these trials were published in Lancet Neurology in 2021. And before we move on to the findings of the meta-analysis, it's worth noting that they had included a mix of patients, some were oral anticoagulant–naive, and some had developed their index intracranial hemorrhage while already on treatment with anticoagulants or antiplatelet therapies. OK, now on to their findings, as mentioned, we're going to review three outcomes of recurrent thromboembolism, recurrent intracranial hemorrhage, and all-cause death for the following three groups: group one, oral anticoagulant therapy versus no therapy; group two, oral anticoagulation therapy versus either antiplatelet treatment or no therapy; group three, comparing new oral anticoagulants versus warfarin. So, for the first outcome of recurrent thromboembolic events in group one, when comparing oral anticoagulant therapy to no therapy, the study showed a significant reduction in thromboembolic events in favor of oral anticoagulation compared to no therapy. That's great news. Next, analysis of the studies that compared oral anticoagulation versus either antiplatelets or no therapy didn't show the same difference in prevention of embolic events in favor of either groups. Actually, no difference was noted between the two groups. Number three, now, in terms of comparing NOACs to warfarin, three studies had the information on this comparison, and they reported a significant reduction in the risk of thromboembolic events with NOAC as compared to warfarin. So, great news for oral anticoagulation overall, and especially for NOACs. Now, on the next outcome. Our second outcome was a recurrent intracranial hemorrhage. Keeping in mind that they included some studies where the outcome was defined as any form of intracranial hemorrhage, meaning they included subdurals, epidurals, etc., and some studies only included the outcome of intracerebral hemorrhage. So, on to the first group, comparing oral anticoagulants to no therapy, the pooled estimate revealed no statistically significant difference between oral anticoagulant–treated patients to those who were not treated with any antithrombotics on the risk of recurrent intracranial hemorrhage. That's great news. Next, on our second group, for the same outcome of recurrent intracranial hemorrhage, comparing oral anticoagulants to either antiplatelet therapy or no treatment, they found that oral anticoagulation was associated with a higher risk of recurrent intracranial hemorrhage as compared to antiplatelets or no therapy. And finally, third group comparing new oral anticoagulants to warfarin for the same outcome, the risk of recurrent intracranial hemorrhage was significantly reduced in patients treated with NOACs as compared to warfarin. And now, we're finally on to our last outcome of the study, which is the outcome of all-cause mortality. So, again back to group one, comparing oral anticoagulants to no therapy, this meta-analysis showed a significant reduction in all-cause mortality rate associated with oral anticoagulation. That's, again, great news. Next group, for the same outcome of mortality, comparing oral anticoagulants to either antiplatelet therapy or no treatment, they found no significant difference in the mortality rates between the two groups. And finally, comparing NOACs to warfarin, the pooled estimate showed that NOACs were associated with a significantly reduced risk of all-cause mortality. Amazing news for NOACs. So, in summary, here's what we learned from this big study. Oral anticoagulation use after intracranial hemorrhage in patients with atrial fibrillation did significantly reduce the risk of thromboembolic events and all-cause mortality without significantly increasing the risk of recurrent intracranial hemorrhage. In general, new oral anticoagulants, or NOACs, are preferred to warfarin as they do prevent embolic events with a lower risk of recurrent intracranial hemorrhage. But, of course, we still have a lot more questions. For instance, would any of the outcomes mentioned above be different in patients with lobar intracerebral hemorrhage, a condition typically associated with amyloid angiopathy, which carries a high risk of development of intracerebral hemorrhage? Also, we have to keep in mind that the majority of the studies included in the meta-analysis were observational. So, there remains an urgent need for a larger randomized trial on this subject, and we have to stay tuned for more research. Cerebral venous sinus thrombosis, or CVST, is an uncommon form of stroke resulting in headaches, seizure, or focal neurological symptoms due to either intracranial hemorrhage or venous ischemic infarcts. The rarity of the disease has made it difficult to study as part of randomized trials, so current treatment guidelines for CVST are consensus-based with much of the recommendations extrapolated from data on treatment of patients with systemic deep vein thrombosis. In general, based on the current evidence, the field agrees that a patient with CVST should be anticoagulated. The decision that is difficult and sometimes inappropriately delayed in the setting of acute hemorrhage in the brain. And not surprisingly, there's significant equipoise around the choice of anticoagulant, duration of therapy, and the role of heroic therapies, especially in the acute setting. Currently, there are a number of ongoing trials to address some of these issues. The direct oral anticoagulants present an attractive alternative to vitamin K antagonists for treatment of patients with CVST. This is partly because of their convenience of use. But how do direct anticoagulants compare in safety and efficacy to the vitamin K antagonists in the setting of CVST is less known. In our March podcast, we reviewed the results of ACTION-CVT, which was a multicenter international study that compared the safety and efficacy profile of the direct oral anticoagulants to that of warfarin in routine practice. The study included over a thousand imaging-confirmed CVST patients from multiple centers in the US, Italy, Switzerland, and New Zealand. And if you missed it, no worries at all. We're here to review some of the results again, as in this issue of the journal, many of the ACTION-CVT investigators, led by Dr. Shadi Yaghi, present the results of a systematic review and meta-analysis comparing the safety and efficacy of DOACs, or direct oral anticoagulants, to that of vitamin K antagonists. I'm joined today by Dr. Yaghi himself to discuss ACTION-CVT and the current meta-analysis. Dr. Yaghi is a Director of Vascular Neurology at Lifespan and Co-Director of Comprehensive Stroke Center and a Director of Research at the Neurovascular Center at Rhode Island Hospital. Good afternoon, Shadi, and welcome to our podcast. Dr. Shadi Yaghi:               Good afternoon, Dr. Asdaghi. Thank you so much for having me. Dr. Negar Asdaghi:         Thank you. And please call me Negar. Congrats on the paper. Before we talk about the meta-analysis, can you please remind us of the results of ACTION-CVT and why the systematic review, in your opinion, was an important next step to that effort? Dr. Shadi Yaghi:               Thank you so much for having me and for bringing up ACTION-CVT. So ACTION-CVT is a real-world multicenter international study that used real-world observational data to compare the safety and efficacy of direct oral anticoagulants to vitamin K antagonists in patients with cerebral venous thrombosis. The reason why we did ACTION-CVT was, as you know, cerebral venous thrombosis is a rare disease, and it's hard to have large studies that would be powered enough to compare the safety and efficacy of direct oral anticoagulants to vitamin K antagonists. So, most of the studies that were done are small, retrospective. There's one randomized controlled trial, but most of them are underpowered to detect the difference between the two groups. So, we decided to do a large-scale international multicenter study using real-world data to compare the safety and efficacy of both. Dr. Negar Asdaghi:         OK, so we're glad you did. Let's start with the methodology of the current meta-analysis. Can you please give us an overview of the inclusion criteria for selection of the papers and the intervention and outcomes that you were interested in? Dr. Shadi Yaghi:               Of course. So, this is a systematic review and meta-analysis that included studies comparing direct oral anticoagulants to vitamin K antagonists in patients with cerebral venous thrombosis. The studies needed to have the two groups included, the direct oral anticoagulants and vitamin K antagonists, and they need to include at least one of the outcomes in our study to compare this outcome between the two groups. In addition, we included articles published in English, and we also included papers that had five patients or more in each group. Dr. Negar Asdaghi:         Perfect. So just recap for our listeners, in order to have been included in the meta-analysis, the paper had to have a reasonable number of patients, and you put that reasonable at the number five, and also they had to have at least one of the outcomes of interest reported in their papers. And those outcomes were either recurrent venous thromboembolism or recanalization rates. Right? Dr. Shadi Yaghi:               Correct. Yes. Dr. Negar Asdaghi:         Perfect. So with that, how many papers did you have to go through to come up with the current number of papers included? Dr. Shadi Yaghi:               That's a great question. We had a little over 10,000 papers, and then we went through a screening process. We used this tool that was developed by Brown University. It's called Abstrackr, and what you do is, we did the search and using several databases like PubMed, Cochrane, and then we included all these studies. We uploaded them in Abstrackr, and Abstrackr was utilized to be able to review all these abstracts and select studies that may or will probably qualify and then go through the studies and details that would qualify. So, we had about 10,000 studies with the initial search, and we had two reviewers go through each abstract, and from these 10,665, we excluded 10,411, and that left us with 254 studies. And then we went through these 254 studies in details. And then finally, we had 19 studies included that met our inclusion/exclusion criteria. And these 19 studies included three randomized control trials and 16 observational studies. Dr. Negar Asdaghi:         Incredible effort. So, three randomized trials in this meta-analysis and 16 observational studies. I think we're very ready to hear the primary outcomes. Dr. Shadi Yaghi:               Yeah, so, the primary outcomes were recurrent venous thrombosis, and that included recurrent venous thromboembolism like peripheral DVTs or PEs, for example, and including recurrent cerebral venous thrombosis. And we know that most of the events are recurrent VTEs, not CVTs, like probably about two-thirds to three-quarters were VTEs, and a third to a quarter were CVT. And then the other efficacy outcome is venous recanalization on follow-up imaging. And we found that direct oral anticoagulants and warfarin were not significantly different in the primary efficacy outcomes. Dr. Negar Asdaghi:         Thank you. I just want to repeat this for our listeners. So, you mentioned some important information here. First one was the fact that about three-quarters of recurrent events were actually systemic thromboembolic events rather than cerebral thromboembolism. So, an important outcome to keep in mind for our practicing physicians. And the fact that DOACs did the same as compared to vitamin K antagonist. So, I think you can already guess my next question, and that is, was there any compromise on the safety profile when using DOACs as compared to vitamin K antagonists in this meta-analysis? Dr. Shadi Yaghi:               Thank you. That's a great question. In ACTION-CVT, we found that there was a lower risk of major hemorrhage with direct oral anticoagulants compared to vitamin K antagonists. In this systematic review and meta-analysis, we didn't find a significant difference, but there were fewer events in patients treated with direct oral anticoagulants versus vitamin K antagonists. This did not reach statistical significance, but if you look at the raw data, it's kind of along the same lines as ACTION-CVT, so the risk of major hemorrhage was about 3.5% with warfarin, and that was about 2% with direct oral anticoagulants. Dr. Negar Asdaghi:         So, again, very important finding, and I want to repeat this for our listeners. So, important finding number one was that there was a superiority in favor of DOACs that you found in terms of a reduced risk of intracerebral hemorrhage in ACTION-CVT. You didn't find this superiority in the meta-analysis, but there was sort of a hint to perhaps lower risk of intracerebral hemorrhage in patients that were treated with DOACs. Did I get that right? Dr. Shadi Yaghi:               Yes, that is correct, and in addition, also major hemorrhage in general, and that included also ICH. Dr. Negar Asdaghi:         Oh, OK, so not just intracranial, but systemic hemorrhages as well. All right. Very good. So, I think my next question would be, why do you think that DOACs have a lower chance of causing hemorrhage? Dr. Shadi Yaghi:               Yeah, that's a really good question. This is not unexpected with DOACs as opposed to vitamin K antagonists. We saw these same trends in patients with atrial fibrillation. We saw improved bleeding profiles with direct oral anticoagulants as compared to vitamin K antagonists. And the risks were along the same lines that we found in patients with cerebral venous thrombosis in ACTION-CVT. Also in the VTE trials as well, there was also reduced bleeding complications with direct oral anticoagulants as compared to vitamin K antagonists. So, it was kind of reassuring to see the same results in patients with cerebral venous thrombosis. Dr. Negar Asdaghi:         Perfect, so kind of expected based on what we know from treatment of systemic conditions with DOACs. The next question I have for you is that in routine practice, treatment of cerebral venous sinus thrombosis almost always starts parenterally with either unfractionated heparin or low molecular weight heparin and then we switch to an oral agent. In the observational studies, did you find any differences in terms of timing of this switch or characteristics of the patients in whom vitamin K antagonists were chosen over direct oral anticoagulants? Dr. Shadi Yaghi:               Thank you very much. Most of the studies did not report these details. I think the one study, off the top of my head, that does report the differences in characteristics between the two groups is RESPECT-CVT. That's the randomized controlled trial comparing dabigatran to vitamin K antagonists. In this study, there was a treatment with parenteral anticoagulation for several days, I think seven to 14 days, prior to transitioning to oral anticoagulation. And this is generally my practice. I typically would treat patients with at least seven days or so parenteral anticoagulation, and once they're clinically stable, then I would transition them to oral anticoagulation, either vitamin K antagonists or direct oral anticoagulant. Dr. Negar Asdaghi:         And I think my next question is along the lines of this question as well. We have several direct oral anticoagulants now available on the market. What was the most common DOACs used for treatment of CVST in these studies, and did you note a preference for the use of any particular agent over others? Dr. Shadi Yaghi:               Thank you so much for the question. Anti-Xa inhibitors were much more common than dabigatran, and the anti-Xa inhibitors most commonly used were apixaban and rivaroxaban. It's in line with what we saw in ACTION-CVT as well, although most of the randomized controlled trials or the largest randomized controlled trial, RESPECT-CVT, used dabigatran, but overall people have been using anti-Xa inhibitors, more particularly apixaban, which was also in line with what we saw in ACTION-CVT. Dr. Negar Asdaghi:         But I think it's fair to say that we don't really have data on superiority of one over others. Is that fair? Dr. Shadi Yaghi:               Yes, that is correct. Dr. Negar Asdaghi:         OK, and so now, where are we at in terms of the future of studies on this topic? We have one ongoing randomized trial now? Dr. Shadi Yaghi:               Yes, we have one randomized controlled trial ongoing, and this is the SECRET trial, and it's looking at rivaroxaban versus vitamin K antagonists in patients with cerebral venous thrombosis. There's another study, it's a prospective observational study that's called the DOAC-CVT study. It's an international study also looking at real-world data prospectively to see if there's a difference in outcomes between the two groups. Dr. Negar Asdaghi:         So, we look forward to the results of those studies. Shadi, a follow-up question I have on this topic is, how long should a duration of therapy be in idiopathic cases of cerebral venous sinus thrombosis? Dr. Shadi Yaghi:               Thank you so much for this question. So, it's unknown at this point for how long should we treat. The key things from the treatment are first achieving venous recanalization, and second is preventing another venous thromboembolic event from happening. So, regarding the venous recanalization, studies have shown that there's not a lot of recanalization beyond four months of treatment. So, a lot of the recanalization really happens early, and continuing anticoagulation beyond the six-months interval, for example, in order to achieve further venous recanalization probably has limited utility. And the second important reason why we treat patients with anticoagulation is also to reduce the risk of a recurrent venous thromboembolic event or cerebral venous thrombosis. And for that, if it's a provoked CVT, then I think usually it's three to six months. If it's unprovoked, up to maybe six to 12 months or even longer, depending on the profile. And if there's a persistent provoking factor, such as cancer, antiphospholipid antibody syndrome, then the treatment is lifelong or until this condition subsides. There's a lot of controversy about the duration of treatment. The European guidelines were very helpful in identifying the duration of treatment. Hopefully, also, we have some guidelines or at least a scientific statement by the AHA that also doles details out and provides some guidance to practitioners. Dr. Negar Asdaghi:         Shadi, what should be our top two takeaways from the current meta-analysis and also ACTION-CVT? Dr. Shadi Yaghi:               So, really, the top two from ACTION-CVT and the meta-analysis are, first is direct oral anticoagulants have a comparable efficacy to vitamin K antagonists in terms of recurrent venous thrombosis and achieving venous recanalization on follow-up imaging. And then the second point is direct oral anticoagulants are probably safer than vitamin K antagonists. We have to keep in mind that this data is based mostly on observational studies. And, as we mentioned earlier, we need more randomized controlled trials to support these findings. Dr. Negar Asdaghi:         Dr. Shadi Yaghi, it was a pleasure interviewing you on the podcast. Thank you very much for joining us, and we look forward to having you back on the podcast and reviewing this topic again in the future. Dr. Shadi Yaghi:               Thank you so much. I appreciate you having me. Dr. Negar Asdaghi:         Thank you. And this concludes our podcast for the October 2022 issue of Stroke Please be sure to check out this month's table of contents for the full list of publications, including an important update from the European Stroke Organisation by Prof. Martin Dichgans. I also want to draw your attention to this month's InterSECT paper, which is our International Stroke Early Career and Training section, to discuss the key topic of burnout and mental health amongst physicians, especially amongst neurologists and stroke neurologists. It's alarming to read in this article that neurology is one of the specialties with the highest reported rates of burnout syndrome, and stroke neurologists are at particularly higher risk than other neurological subspecialties. The article tackles some tough subjects, such as the barriers for physicians to seek help and important strategies to mitigate burnout and how to improve mental health in general. I think it's also timely to know that October is the Mental Health Awareness Month, and the theme for October 2022 is "Back to Basics." The basics of recognizing the burden of stress, anxiety, the burden of isolation and depression, not only on those who we take care of, but also on those who give care to us. So, whether you're a stroke physician, a stroke caregiver, or whether you've been touched by this disease in some way or shape, please know that you are part of the stroke community and a part of our Stroke podcast family. Thank you for listening to us, and, as always, stay alert with Stroke Alert. This program is copyright of the American Heart Association, 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, visit AHAjournals.org.  

HER | Mind Body Life
How Did Menopause Get Medicalized?

HER | Mind Body Life

Play Episode Listen Later Sep 22, 2022


Boy, are we living in wild and crazy times! When it comes to women's healthcare, our heads are spinning. We're getting whiplash from the changes to just about every aspect of women's healthcare from insurance reimbursements to prescriptions.But joining us is someone who can help clear this all up for us, touching on the past and looking towards the future of women's health care in the United States. Elizabeth Watkins became Provost and Executive Vice Chancellor at UC Riverside in May 2021. Her research focuses on the interrelations of medicine, science, commerce, and culture in the U.S. in the twentieth—twenty-first centuries, and she has published on the topics of the history of prescription drugs; birth control; estrogen and female aging; testosterone and male aging; and stress and disease.Her work has been funded by the National Science Foundation, the National Library of Medicine, the National Endowment for the Humanities, and the National Academy of Education. She is the author of On the Pill:  A Social History of Oral Contraceptives and The Estrogen Elixir:  A History of Hormone Replacement Therapy in America.She sits down with Dr. Pam to discuss her career in this field of study, the devaluing of older women in America, and our cultural devotion to youth culture.

HER | Mind Body Life
How Did Menopause Get Medicalized?

HER | Mind Body Life

Play Episode Listen Later Sep 22, 2022


Boy, are we living in wild and crazy times!Boy, are we living in wild and crazy times! When it comes to women's healthcare, our heads are spinning. We're getting whiplash from the changes to just about every aspect of women's healthcare from insurance reimbursements to prescriptions.But joining us is someone who can help clear this all up for us, touching on the past and looking towards the future of women's health care in the United States. Elizabeth Watkins became Provost and Executive Vice Chancellor at UC Riverside in May 2021. Her research focuses on the interrelations of medicine, science, commerce, and culture in the U.S. in the twentieth—twenty-first centuries, and she has published on the topics of the history of prescription drugs; birth control; estrogen and female aging; testosterone and male aging; and stress and disease.Her work has been funded by the National Science Foundation, the National Library of Medicine, the National Endowment for the Humanities, and the National Academy of Education. She is the author of On the Pill:  A Social History of Oral Contraceptives and The Estrogen Elixir:  A History of Hormone Replacement Therapy in America.She sits down with Dr. Pam to discuss her career in this field of study, the devaluing of older women in America, and our cultural devotion to youth culture.

Best Science Medicine Podcast - BS without the BS
Episode 519: Oh Baby – Combined oral contraceptives during breastfeeding

Best Science Medicine Podcast - BS without the BS

Play Episode Listen Later Aug 29, 2022 26:58


In episode 519, Mike and James ask Jen Potter back to the podcast to talk about a common primary care question around oral contraceptives and breast feeding. We review the best available evidence which unfortunately we find out is not the highest quality. Nonetheless, we go over the numbers and then come up with useful, […]

High Intensity Health with Mike Mutzel, MS
Treating the Root Cause of PCOS, Naturally

High Intensity Health with Mike Mutzel, MS

Play Episode Listen Later Jul 9, 2022 25:29 Very Popular


Polycystic ovary syndrome (PCOS) is a common condition impacting roughly one in four women of reproductive age. , In this show we discuss natural ways to reverse the underlying factors driving PCOS.  Save 15% OFF on Berberine HCl and Myo-Inositol containing Sleep Formulations from MYOXCIENCE Save with code podcast at checkout  Links to Studies, Images and the Video Version: https://bit.ly/3nMt9QJ Time Stamps 00:04 PCOS (polycystic ovarian syndrome) is about 1 in 5 of women of childbearing age. 00:26 The root cause of PCOS is poor metabolic health. 01:54 Ovaries hyper secrete androgens that are linked with challenges within the ovaries and the formation of water-forming cysts. 02:39 Hormonal birth control is frequently prescribed to increase sex hormone binding globulin and neutralize the elevated androgens. 04:04 Some cytochrome P450 enzymes are involved in the formation of steroid-like hormones, like testosterone. 05:04 Insulin and IGF-1 increase the activity of a cytochrome P450 enzyme called CYP17A1, which then increases testosterone, dihydrotestosterone, and DHEA within the ovaries. 06:36 Excessive levels of androgens cause hair loss, infertility, lack of ovulation, and cause the formation of water forming cysts within the ovaries. 08:24 Autoimmunity often co-occurs with PCOS. 08:44 Deliberate cold exposure helps metabolic health by stimulating brown and beige fat cells. 09:54 Metabolic health increases the activity of enzymes that create hormones. It does the inverse in men and women. 10:04 Men's poor metabolic health drives the formation of extra estrogen. 10:14 Women's poor metabolic health drives the formation of extra testosterone. 12:44 97% of obese women have PCOS. 65% of non-obese women have PCOS. 13:14 Fat cells secrete hormones, called adipocytokines. One of these is leptin. 13:54 Leptin decreases activity of T-regulatory cells that help to prevent autoimmunity. 16:04 Belly fat cells convert androgens into estrogens. This is impacted by insulin. 18:14 Nutrition and exercise are fundamental ways to address poor metabolic health. 18:24 A ketogenic or low carb diet is helpful because it manages blood sugar and insulin, and ketones have immune signaling properties. 19:24 Intermittent fasting can support glycemic variability and improve insulin sensitivity. 19:46 Time restricted feeding with a 16 or 18 hour fast is also helpful for longevity, burning fat, and supporting metabolic health. 20:14 Poor sleep exacerbates insulin resistance. Tape your mouth shut when you sleep. 21:24 Resistance training decreases androgens in women with PCOS. All exercise supports underlying metabolic dysfunction. 22:24 Magnesium is helpful for supporting insulin sensitivity. 23:15 Myo-inositol and inositol makes ovaries more sensitive to insulin, preventing the increase in androgens. 24:04 Vitamin D is involved in blood sugar regulation, immune health, and sleep quality. 24:19 Gut health is important to metabolic health. Eat real food and ferments. 24:54 Berberine hydrochloride, 500 mg 1 to 3 times per day, is a natural Metformin. Studies Mentioned Witchel, S. F., & Plant, T. M. (2020). Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome. Current Opinion in Endocrine and Metabolic Research, 14, 127–136. http://doi.org/10.1016/j.coemr.2020.07.004 Stefanaki, C., Bacopoulou, F., Kandaraki, E., Boschiero, D., & Diamandi-Kandarakis, E. (2019). Lean Women on Metformin and Oral Contraceptives for Polycystic Ovary Syndrome Demonstrate a Dehydrated Osteosarcopenic Phenotype: A Pilot Study. Nutrients, 11(9), 2055. http://doi.org/10.3390/nu11092055 Moghetti, P., & Tosi, F. (2020). Insulin resistance and PCOS: chicken or egg? Journal of Endocrinological Investigation, 44(2), 233–244. http://doi.org/10.1007/s40618-020-01351-0 Scarfò, G., Daniele, S., Fusi, J., Gesi, M., Martini, C., Franzoni, F., et al. (2022). Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome. Biomedicines, 10(6), 1305. http://doi.org/10.3390/biomedicines10061305 Witchel, S. F., & Plant, T. M. (2020). Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome. Current Opinion in Endocrine and Metabolic Research, 14, 127–136. http://doi.org/10.1016/j.coemr.2020.07.004 Optimal management of polycystic ovary syndrome in adolescence. (2015). Optimal management of polycystic ovary syndrome in adolescence, 1–8. http://doi.org/10.1136/archdischild-2014-306471&domain=pdf&date_stamp=2015-06-22

Wellness Women Radio
WWR 224: Pros & Cons of Oral Contraceptives

Wellness Women Radio

Play Episode Listen Later Jun 27, 2022 38:11


On this episode of Wellness Women Radio, Dr Andrea & Dr Ashleigh go over some absolute fundamentals about your contraceptive choices that all women need to know! – this is all of the essentials that should absolutely form part of school education! Tune in to learn more about the pros & cons of taking oral Listen In The post WWR 224: Pros & Cons of Oral Contraceptives appeared first on The Wellness Couch.

Women's Health Interrupted
S1 E10: How do Oral Contraceptives Impact Your Brain Health?

Women's Health Interrupted

Play Episode Listen Later Jun 8, 2022 26:12


In this week's episode, we sit down with Dr. Emily Jacobs and Dr. Cailtin Taylor to discuss how oral contraceptives (OC) impact women's brain health. We break down the science behind oral contraceptives, discover gaps in research, and discuss the need for safer birth control options for women.Rate, review, and subscribe to our podcast on your favourite podcast platform. Don't forget to check out the family of podcasts on the UBC Medicine Learning Network.(C) 2022 UBC Medicine Learning Network

The Stronger By Science Podcast
Sumo Deadlifts, Procrastination, and Oral Contraceptives

The Stronger By Science Podcast

Play Episode Listen Later May 5, 2022 85:01 Very Popular


Today's episode features a crazy (and historic) Feat of Strength, which leads into a discussion about whether or not sumo deadlifting is cheating. After that, Eric answers a few questions from listeners about topics including easy vegetarian protein sources, how to deal with a tendency to procrastinate, how long a weight loss phase can last, and whether or not you should have a maintenance phase immediately after a bulking phase. Finally, to close out the show, Greg discusses his recent article about how oral contraceptives impact (or don't impact) training adaptations, along with a brief discussion about some good (and absolutely terrible) television show endings. SUPPORT THE PODCASTReceive our Research Spotlight newsletter, and check out our Facebook group and subreddit.MacroFactorIf you want to learn more about our MacroFactor diet app, check it out  here.To join in on the MacroFactor conversation, check out our Facebook group and subreddit.MASS Research ReviewSubscribe to the MASS Research Review to get concise and applicable breakdowns of the latest strength, physique, and nutrition research – delivered monthly.Bulk SupplementsFinally, next time you stock up on supplements from BulkSupplements.com, be sure to use the promo code “SBSPOD” (all caps) to get 5% off your entire order. TIME STAMPSIntro/Announcements (0:00)Road to the Stage / Road to Athens (1:37)Feats of Strength (9:42)Krzysztof WierzbickiIs the sumo deadlift cheating? (11:50)Is The Sumo Deadlift Cheating? (Jeff Nippard video)Should You Deadlift Conventional Or Sumo?Q&A (34:46)Considering the road to enlightenment: is there a vegetarian variation of the culinary shredded chicken staple? (35:05)Any insight on dealing with procrastination? (37:21)If you intend to lose a lot of weight, should you break the cut into 12-week increments with some maintenance periods in between, or lose it all in one continuous cut? (54:14)More info on diet breaksDo you need to do a maintenance period after a bulk to effectively retain the newly added muscle mass? (57:47)SBS Article Discussion: Do Oral Contraceptives Affect Your Gains? (1:04:45)Do Oral Contraceptives Affect Your Gains?Molecular markers of skeletal muscle hypertrophy following 10 wk of resistance training in oral contraceptive users and nonusersTo Play Us Out: Endings of television seasons/shows (1:17:34)

GYN Corner
OCPs and a dangerous medical history!

GYN Corner

Play Episode Listen Later Mar 3, 2022 12:36


Oral Contraceptives should be avoided by certain Women. --- Send in a voice message: https://anchor.fm/dr-mcdaniel/message

Prestasjonsprat
Styrketrening og menstruasjonssyklus

Prestasjonsprat

Play Episode Listen Later Jan 28, 2022 44:45


Idrettsfysiolog og masterstudent,med spesialisering innen kvinnelig fysiologi, Gina Flugstad Øistuen er tilbake som gjest mens Eirik prøver å få avgårde en tropp til sesongens største mesterskap og det har bydd på noen utfordringer. I episoden lærer du om den forskningen vi har til nå på hvordan styrketreningen og effektene av den påvirkes av menstruasjonssyklus på kort og lang sikt. Det er duket for en skikkelig fysiologitime der du lærer om sentrale hormoner, men vi kommer som alltid med praktiske råd også. God lytt og god læring!For mer innhold om kvinnelig fysiologi følg Gina på Instagram https://www.instagram.com/ginaflugstado/Oss finner du på https://www.instagram.com/prestasjonsprat/Refereranser: Thompson, B., Almarjawi, A., Sculley, D., & Janse de Jonge, X. (2020, Jan). The Effect of the Menstrual Cycle and Oral Contraceptives on Acute Responses and Chronic Adaptations to Resistance Training: A Systematic Review of the Literature. Sports Medicine, 50(1), 171-185. https://doi.org/10.1007/s40279-019-01219-1 Carmichael, M. A., Thomson, R. L., Moran, L. J., & Wycherley, T. P. (2021, Feb 9). The Impact of Menstrual Cycle Phase on Athletes' Performance: A Narrative Review. International Journal of Environmental Research and Public Health, 18(4). https://doi.org/10.3390/ijerph18041667Blagrove, R. C., Bruinvels, G., & Pedlar, C. R. (2020, Dec). Variations in strength-related measures during the menstrual cycle in eumenorrheic women: A systematic review and meta-analysis. Journal of Science and Medicine in Sport, 23(12), 1220-1227. https://doi.org/10.1016/j.jsams.2020.04.022 Chidi-Ogbolu N, Baar K. Effect of Estrogen on Musculoskeletal Performance and Injury Risk. Front Physiol. 2019 Jan 15;9:1834. doi: 10.3389/fphys.2018.01834. PMID: 30697162; PMCID: PMC6341375.https://www.frontiersin.org/articles/10.3389/fphys.2018.01834/full See acast.com/privacy for privacy and opt-out information.

Prestasjonsprat
Menstruasjon, prevensjon og prestasjon med Gina Flugstad Øistuen fra FENDURA

Prestasjonsprat

Play Episode Listen Later Dec 2, 2021 80:27


Eirik har reist på på verdenscup i langrenn og Melina tar podden i egne hender denne uken og har fått masterstudent på Institutt for fysisk prestasjonsevne ved Norges Idrettshøgskole,Gina Flugstad Øistuen som gjest. Gina jobber på FENDURA-prosjektet (The Female Endurance Athlete) som er et multisenterprosjekt ledet av UiT, som skal tette kunnskapshullene om kvinnelig fysiologi og den kvinnelige utøveren når det kommer til treningsutvikling og prestasjon. Ved siden av masterstudiene er Gina langrennsløper på Team XPND Fuel og satser langløp på profesjonelt nivå, hun er langrennstrener, fysisk trener og holder foredrag og workshops om kvinnelig fysiologi og prestasjon. Vi tar opp hvordan menstruasjonssyklusen styres, hvorfor tracke syklusen, hvordan kan du tracke syklusen din enten du bruker hormonprevensjon eller ikke, kan prevensjonsmidler påvirke prestasjonen, hvordan periodisere treningen utfra din syklus, er man mer utsatt for skader på noen tidspunkter i syklusen. Delta i FENDURA-studie? Ønsker foredrag til ditt idrettslag? Kontakt Gina Flugstad Øistuen: gina.oistuen@hotmail.com På Instagram: @ginaflugstadoFENDURA: https://uit.no/research/fenduraApp til å tracke syklus: https://www.fitrwoman.com/Referanser: McNulty et al. (2020). The Effects of Menstrual Cycle Phase on Exercise Performance in Eumenorrheic Women: A Systematic Review and Meta-Analysis. Sports Med. 50(10):1813-1827. doi: 10.1007/s40279-020-01319-3. PMID: 32661839; PMCID: PMC7497427.https://pubmed.ncbi.nlm.nih.gov/32661839/Thompson et al. (2020). The Effect of the Menstrual Cycle and Oral Contraceptives on Acute Responses and Chronic Adaptations to Resistance Training: A Systematic Review of the Literature. Sports Med. 50(1):171-185. doi: 10.1007/s40279-019-01219-1. PMID: 31677121.https://pubmed.ncbi.nlm.nih.gov/31677121/Elliott-Sale et al. (2020).. The Effects of Oral Contraceptives on Exercise Performance in Women: A Systematic Review and Meta-analysis. Sports Med. 50(10):1785-1812. doi: 10.1007/s40279-020-01317-5. PMID: 32666247; PMCID: PMC7497464.https://pubmed.ncbi.nlm.nih.gov/32666247/Solli et al. (2020). Changes in Self-Reported Physical Fitness, Performance, and Side Effects Across the Phases of the Menstrual Cycle Among Competitive Endurance Athletes. Int J Sports Physiol Perform. 21:1-10. doi: 10.1123/ijspp.2019-0616. Epub ahead of print. PMID: 32957079.https://pubmed.ncbi.nlm.nih.gov/32957079/ See acast.com/privacy for privacy and opt-out information.

Covid19infovaccines
6 12 I Am Using A Hormonal Contraceptive Method Oral Contraceptives, Subdermal Implant, Skin Patches

Covid19infovaccines

Play Episode Listen Later Dec 1, 2021 0:47


6 12 I Am Using A Hormonal Contraceptive Method Oral Contraceptives, Subdermal Implant, Skin Patches by WHO Collaborating Center for Vaccine Safety

Did That Really Happen?
Portrait of a Lady on Fire

Did That Really Happen?

Play Episode Listen Later Oct 4, 2021 61:55


This week we travel back to 18th century France with Portrait of a Lady on Fire! Join us as we talk about female artists, Vivaldi's Four Seasons, herbal abortifacients, flying ointment (aka "the armpit scene") and more! Sources: Female Painters: Laura Auricchio, "Eighteenth-Century Women Painters in France," The Met Museum (October 2004), https://www.metmuseum.org/toah/hd/18wa/hd_18wa.htm Cath Pound, "The great women artists that history forgot," BBC (19 October 2016), https://www.bbc.com/culture/article/20161019-the-great-women-artists-that-history-forgot Heidi A. Strobel, "Royal "matronage" of Women Artists in the Late-18th Century," Woman's Art Journal 26:2 (2005-2006): 3-9. https://www.jstor.org/stable/3598091 Catherine R. Montfort, "Self-Portraits, Portraits of Self: Adelaide Labille-Guiard and Elisabeth Vigee Lebrun, Women Artists of the Eighteenth Century," Pacific Coast Philology 40:1 (2005): 1-18. https://www.jstor.org/stable/25474166 Laura Auricchio, "Self-Promotion in Adelaide Labille-Guiard's 1785 Self-Portrait with Two Students," 89:1 (March 2007): 45-62. https://www.jstor.org/stable/25067300 The Four Seasons: Betsy Schwarm, "Why should you listen to Vivaldi's "Four Seasons"? - Betsy Schwarm," TED-Ed YouTube (24 October 2016), https://youtu.be/Xcpc8VDsv3c "VIVALDI: "Four Seasons" Sonnets texts in Italian & English," https://www.baroquemusic.org/vivaldiseasons.html https://www.charlottesymphony.org/blog/vivaldis-four-seasons-poems/ Film Background: Rotten Tomatoes: https://www.rottentomatoes.com/m/portrait_of_a_lady_on_fire Ela Bittencourt, "Portrait of a Lady on Fire: Daring to See," The Criterion Collection (23 June 2020), https://www.criterion.com/current/posts/6991-portrait-of-a-lady-on-fire-daring-to-see Mark Kermode, "Portrait of a Lady on Fire review - mesmerised by the female gaze," The Guardian (1 March 2020), https://www.theguardian.com/film/2020/mar/01/portrait-of-a-lady-on-fire-review-celine-sciamma "The Fine Brushstrokes Of 'Portrait Of A Lady On Fire'" NPR https://www.npr.org/2020/02/24/809112455/the-fine-brushstrokes-of-portrait-of-a-lady-on-fire Hilary Weaver, "Portrait of a Lady On Fire Is A Queer Survival Guide To Self-Isolation," ELLE (28 March 2020), https://www.elle.com/culture/movies-tv/a31965622/portrait-of-a-lady-on-fire-self-isolation-coronavirus-guide/ Carlos Aguilar, "Love Dialogue: Celine Sciamma on Portrait of a Lady on Fire," (12 February 2020) https://www.rogerebert.com/interviews/love-dialogue-c%C3%A9line-sciamma-on-portrait-of-a-lady-on-fire Drew Gregory, "Celine Sciamma on "Portrait of a Lady on Fire," the Lesbian Gaze, and Queer TV That Gives Her Hope," Autostraddle (12 February 2020), https://www.autostraddle.com/celine-sciamma-on-portrait-of-a-lady-on-fire-the-lesbian-gaze-and-queer-tv-that-gives-her-hope/ https://www.telerama.fr/ecrans/regardez-le-brulant-portrait-de-la-jeune-fille-en-feu-de-celine-sciamma-sur-arte.tv-6966315.php Herbal Abortifacients: Boyce Rensberger, "Pharmacology," Washington Post, 25 July 1994, available at https://www.washingtonpost.com/archive/politics/1994/07/25/pharmacology/573a3a65-8038-482c-9097-0cf992d72929/ Londa Schiebinger, "Agnotology and Exotic Abortifacients: The Cultural Production of Ignorance in the Eighteenth-Century Atlantic World," Proceedings of the American Philosophical Society 149, 3 (2005) John M. Riddle and J. Worth Estes, "Oral Contraceptives in Ancient and Medieval Times," American Scientist 80, 3 (1992) John m. Ridde, J. Worth Estes, and Josiah C. Russell, "Ever Since Eve. . . Birth Control in the Ancient World," Archaeology 47, 2 (1994) Lucille F. Newman, "Ophelia's Herbal," Economic Botany 33, 2 (1979) BTM, "Early Abortifacients," Pharmacy in History 35, 2 (1993) Flying Ointment: Karsten Fatur, "Peculiar Plants and Fantastic Fungi: An Ethnobotanical Study of the Use of Hallucinogenic Plants and Mushrooms in Slovenia." PLOS One 16 (1) 2021 David MJ Carruthers, "Lines of Flight: An Enquiry Into the Properties of the Magical Plant, It's Literature and History," Mosaic, an Interdisciplinary Critical Journal 48, 2 (2015) Clive Harper, "The Witches' Flying Ointment," Folklore 88, 1 (1977) Michael Ostling, "Witches' Herbs on Trial," Folklore 125, 2 (2014) Danielle Piomelli and Antonino Pollio, "In Upupa O Strige: A Study in Renaissance Psychotropic Plant Ointments," History and Philosophy of the Life Sciences 16, 2 (1994)

Paige Talks Wellness
39: 3 Surprising Things That Could Be Irritating Your Gut

Paige Talks Wellness

Play Episode Listen Later Sep 8, 2021 23:21


We've all heard to eliminate dairy, grains, and added sugars to try and solve gut issues, but that's not always the answer. In this episode, I touch on 3 things that could be messing with your gut without you realizing it -- and number 3 is definitely the biggest reason that I see with my clients! If you're looking to balance your hormones, heal your gut, and transform your relationship with food in a way that lets you achieve true wellness WITHOUT obsession, be sure to get inside my Gut Instinct DIY Program before the price increases! Show Notes: Gut Instinct DIY Program FoodData Central The latex-fruit syndrome Oral contraceptives, reproductive factors and risk of inflammatory bowel disease Risk of Inflammatory Bowel Disease with Oral Contraceptives and Menopausal Hormone Therapy: Current Evidence and Future Directions Estrogen Rather Than Progesterone Cause Constipation in Both Female and Male Mice Malabsorption Syndromes Oral contraceptive use and increased plasma concentration of C-reactive protein The Chemistry of the Pill Brain-gut interactions in inflammatory bowel disease Schedule a 1:1 Discovery Call - I have a few new client spaces available now. You can learn more about me by following on IG @imperfectlypaigewellness or by checking out my blog, freebies, and offers on my website: https://imperfectlypaigewellness.com Please share with #PaigeTalksWellness to help get the word out about the show - and join the Imperfect Health Fam over on Facebook.

Never Generic Podcast
Episode 17: What is the Future of Oral Contraceptives?

Never Generic Podcast

Play Episode Listen Later Aug 30, 2021 70:46


In this episode of Never Generic Podcast, we will be delving into the topic of

Sam Miller Science
S 234: A Surprising Study on Women and Birth Control that Coaches Should Know

Sam Miller Science

Play Episode Listen Later Aug 30, 2021 21:35


There's been few hotter topics in the health and fitness industry than women's health and women's hormones. An important subtopic of that is the role of contraceptives on women who are trying to build muscle or lose fat in their transformation. In this episode, we cover important considerations based on what the research says about potentially beneficial supplements you can add (with the advice of your doctor) to your health regiment. Topics include:   - Oral Contraceptives - 2016 Study - Functional Nutrition and Metabolism Science Specialization - Takeaways and Age Range Consideration - DHEA Addition - Share, Rate, and Review ---------- Apply for the Latest Cohort of the Functional Nutrition and Metabolism Science Specialization ---------- “This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at team@sammillerscience.com. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast.”

GYN Corner
Oral Contraceptives and Acne

GYN Corner

Play Episode Listen Later Aug 6, 2021 17:05


How the pill effects acne, the 411. --- Send in a voice message: https://anchor.fm/dr-mcdaniel/message

Endurance Planet
HPN 28: Oral Contraceptives Impair Lean Mass Gains, Plus: Deep Dive Into Mental Health and Menstrual Recovery For Athletes, Coaches and More

Endurance Planet

Play Episode Listen Later Jul 16, 2021 63:40


  Welcome to episode 28 of Holistic Performance Nutrition (HPN) featuring Tawnee Gibson, MS, CSCS, CISSN, and Julie McCloskey, a certified holistic nutrition coach who you can find over at wildandwell.fit. On this episode: Intro All things summer & healthy balance Julie and Tawnee life updates, with Julie’s approach to healthy 50k training (more sleep, […] The post HPN 28: Oral Contraceptives Impair Lean Mass Gains, Plus: Deep Dive Into Mental Health and Menstrual Recovery For Athletes, Coaches and More first appeared on Endurance Planet.

Ask Stago
S2E14 - Oral contraception and thrombotic risk

Ask Stago

Play Episode Listen Later Jul 6, 2021 8:08


Welcome to Ask Stago, the podcast dedicated to provide expert answers to your expert questions in hemostasis.  In today episode, our expert guest, Laure Morimont, Project leader at QUALIblood SA, will detail with us the current knowledge on thrombotic risk under hormonal therapy and how this can be assessed.    As usual, don't forget to send any question you may have to ask@stago.com, we will be glad to answer to it.  Learn more ⬇️ Literature sources:  de Bastos  M, Stegeman  BH, Rosendaal  FR, Van Hylckama Vlieg  A, Helmerhorst  FM, Stijnen  T, Dekkers  OM. Combined oral contraceptives: venous thrombosis. Cochrane Database of Systematic Reviews 2014, Issue 3. Art. No.: CD010813. DOI: 10.1002/14651858.CD010813.pub2. Accessed 16 June 2021.  Douxfils J, Morimont L, Bouvy C. Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk. Semin Thromb Hemost. 2020 Nov;46(8):872-886. doi: 10.1055/s-0040-1714140. Epub 2020 Oct 20. PMID: 33080636.  Abou-Ismail MY, Citla Sridhar D, Nayak L. Estrogen and thrombosis: A bench to bedside review. Thromb Res. 2020 Aug;192:40-51. doi: 10.1016/j.thromres.2020.05.008. Epub 2020 May 11. PMID: 32450447; PMCID: PMC7341440.  Morimont L, Dogné JM, Douxfils J. Letter to the Editors-in-Chief in response to the article of Abou-Ismail, et al. entitled "Estrogen and thrombosis: A bench to bedside review" (Thrombosis Research 192 (2020) 40-51). Thromb Res. 2020 Sep;193:221-223. doi: 10.1016/j.thromres.2020.08.006. Epub 2020 Aug 5. PMID: 32798963.  Visit QUALIblood website: https://www.qualiblood.eu   Content is scientific and technical in nature. It is intended as an educational tool for laboratory professionals and topics discussed are not intended as recommendations or as commentary on appropriate clinical practice.   

Den kvinnelige utøveren
Kartlegging av syklus og hvordan prevensjonsmiddel påvirker utholdenhetsprestasjon

Den kvinnelige utøveren

Play Episode Listen Later Jun 14, 2021 54:35


Podkasten inneholder reklame for Fuel of Norway og Ekte vare. I den fjerde episoden av “den kvinnelige utøveren” snakker vi om hvordan prevensjonsmiddel påvirker utholdenhetsprestasjon, samt hvordan og hvorfor du skal kartlegge menstruasjonssyklus/prevensjonsmiddel syklus. Vi diskuterer fordeler og ulemper med ulike apper du kan kartlegge syklus i, og typiske symptomer idrettsjenter rapporterer er tilknyttet menstruasjonssyklus/prevensjonsmiddel. Og ikke minst har vi begge to både gode og mindre gode nyheter å dele fra treningsfronten! Tips til apper for å kartlegge syklus: Wild Ai, Fitr Woman, Garmin, Clue og Flow. Kilder: Elliott-Sale, K. J., McNulty, K. L., Ansdell, P., Goodall, S., Hicks, K. M., Thomas, K., Swinton, P. A., & Dolan, E. (2020, Oct). The Effects of Oral Contraceptives on Exercise Performance in Women: A Systematic Review and Meta-analysis. Sports Medicine, 50(10), 1785-1812. Martin, D., Sale, C., Cooper, S. B., & Elliott-Sale, K. J. (2018, Aug 1). Period Prevalence and Perceived Side Effects of Hormonal Contraceptive Use and the Menstrual Cycle in Elite Athletes. Elliott-Sale, K., & Hicks, K. (2018). Hormonal-Based Contraception and the Exercising Female. In J. Forsyth, & C-M. Roberts (Eds.), The Exercising Female: Science and Its Application (Routledge Research in Sport and Exercise Science). Taylor & Francis.

Ask Stago
S2E11 - What is thrombin generation?

Ask Stago

Play Episode Listen Later May 25, 2021 9:04


Welcome to Ask Stago, the podcast dedicated to provide expert answers to your expert questions in haemostasis.  In today episode, our expert Marisa Ninivaggi, research project leader at Synapse research institute, will explain us what is thrombin generation.  As usual, don’t forget to send any question you may have to Ask@stago.com, we will be glad to answer to it.  Learn more  

Stuff You Missed in History Class
The Nelson Pill Hearings

Stuff You Missed in History Class

Play Episode Listen Later May 5, 2021 45:55


In the U.S., the idea that people should know about the risks involved with the drugs that they are taking is tied directly to the complicated and often troubling history of oral contraceptives.  Tracy's Research: Gutierrez, Kirsten. “Health experts: Blood clots from J&J vaccine and birth control are very different.” WRAL. 4/13/2021. https://www.wral.com/coronavirus/health-experts-blood-clots-from-j-j-vaccine-and-birth-control-are-very-different/19625592/ American Experience. “Senate Hearings on the Pill.” https://www.pbs.org/wgbh/americanexperience/features/pill-senate-holds-hearings-pill-1970/ Thomas, Robert Mcg. Jr. “Hugh J. Davis, 69, Gynecologist Who Invented Dalkon Shield.” New York Times. 10/26/1996. https://www.nytimes.com/1996/10/26/us/hugh-j-davis-69-gynecologist-who-invented-dalkon-shield.html Time. “Medicine: The Pill on Trial.” 1/26/1970. http://content.time.com/time/subscriber/article/0,33009,878746-1,00.html Gura, Trisha. “Opening Eyes.” Oberlin Alumni Magazine. Spring 2004. https://www2.oberlin.edu/alummag/spring2004/feat_eyes.html Jewish Women's Archive. "Barbara Seaman." (Viewed on April 14, 2021) . Knowles, Jon. “The Birth Control Pill – A History.” Planned Parenthood. 2013. https://www.plannedparenthood.org/files/1213/9611/6329/pillhistory.pdf Watkins, Elizabeth Siegel. “On the Pill: A Social History of Oral Contraceptives, 1950-1970.” Johns Hopkins University Press. 1998. Fitzpatrick, Jane Brodsky. "Seaman, Barbara." The Scribner Encyclopedia of American Lives, edited by Arnold Markoe, et al., vol. 8: 2006-2008, Charles Scribner's Sons, 2010, pp. 440-441. Gale In Context: Biography, link.gale.com/apps/doc/CX1347100261/GPS?u=mlin_n_melpub&sid=GPS&xid=3f70d978. Accessed 14 Apr. 2021. Watkins, Elizabeth Siegel. “Expanding Consumer Information: The Origin of the Patient Package Insert.” Advancing the Consumer Interest Volume 10 Number 1 / Spring 1998. Via JSTOR. https://www.jstor.org/stable/23862430 Junod, Suzanne White and Lara Marks. “Women’s Trials: The Approval of the First Oral Contraceptive Pill n the United States and Great Britain.” Journal of the History of Medicine. Vol. 57, April 2002. Oxford University Press. O’Donnell, Kelly. “Our Doctors, Ourselves: Barbara Seaman and Popular Health.” Bulletin of the History of Medicine. Vol. 93, No. 4, Winter 2019. https://muse.jhu.edu/article/744905 Sigal, Regina. “politics of the pill.” Off Our Backs. 2/27/1970. https://www.jstor.org/stable/25770946 Blair, Sandra. “Liability of Birth Control Pill Manufacturers.” Hastings Law Journal. Vol. 23, Issue 5. 1/1972. https://repository.uchastings.edu/hastings_law_journal  Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

Better with Dr. Stephanie
The Pill Influences Mate Selection with Dr. Jolene Brighten

Better with Dr. Stephanie

Play Episode Listen Later Apr 16, 2021 8:31


Welcome to Betty Bites. In this episode, we welcome Dr. Jolene Brighten. Jolene is a best-selling author and leading authority on women’s health and joins the podcast to share her experience in the field of hormonal birth control. As a prominent expert in women’s medicine and post-birth control syndrome, Dr. Jolene understands both the positive and negative effects hormonal contraceptives can have on women. In this episode, we discuss the effects on mate selection with the use of hormonal contraceptives.  Join The Better! Community On Facebook. Get the show notes here.

That Triathlon Show
The menstrual cycle and oral contraception - impact on exercise performance with Kelly McNulty | EP#280

That Triathlon Show

Play Episode Listen Later Apr 5, 2021 60:26


Kelly McNulty is a PhD candidate at Northumbria University. Kelly's research investigates the effect of the menstrual cycle and hormonal contraceptive use on performance, recovery, and adaptation in women in sports. In this interview, Kelly walks as through the evidence-base and practical recommendations for all female athletes and coaches of female athletes.         IN THIS EPISODE YOU'LL LEARN ABOUT: -The different phases and hormonal changes of the menstrual cycles -How these changes (theoretically) might impact exercise performance -The actual evidence-base and state of the science on menstrual cycle phase and its impact on exercise performance -Practical advice for individualising your approach to training according to the menstrual cycle phases -The evidence-base and state of the science on hormonal contraception use and its impact on exercise performance -General advice and takehome messages for female athletes   SHOWNOTES: https://scientifictriathlon.com/tts280/   SCIENTIFIC TRIATHLON AND THAT TRIATHLON SHOW WEBPAGE: www.scientifictriathlon.com/podcast/   SPONSORS: ZEN8 - The ZEN8 Indoor Swim Trainer is a tool for time-crunched triathletes looking to improve swim specific strength and technique. Trusted by BMC PRO Triathlon Team, age-group triathletes, coaches and physios around the world. Visit zen8swimtrainer.com/tts for 20% off your order.   ROKA - The finest triathlon wetsuits, apparel, equipment, and eyewear on the planet. Trusted by Javier Gómez, Gwen Jorgensen, Flora Duffy, Mario Mola, Lucy Charles and others. Visit roka.com/tts for 20% off your order.   LINKS AND RESOURCES: Kelly's website, Twitter and Research Gate "The period of the period" podcast, Twitter, and Instagram The Effects of Menstrual Cycle Phase on Exercise Performance in Eumenorrheic Women: A Systematic Review and Meta-Analysis The Effects of Oral Contraceptives on Exercise Performance in Women: A Systematic Review and Meta-analysis RED-S (Relative Energy Deficiency in Sports) with Margo Mountjoy | EP#233 Training during and after pregnancy with Jocelyn McCauley | EP#33   RATE AND REVIEW: If you enjoy the show, please help me out by subscribing, rating and reviewing: www.scientifictriathlon.com/rate/   CONTACT: Want to send feedback, questions or just chat? Email me at mikael@scientifictriathlon.com or connect on Instagram, Facebook, or Twitter.

Better with Dr. Stephanie
How Your Genes Affect Your Hormones with Dr. Mansoor Mohammed

Better with Dr. Stephanie

Play Episode Listen Later Apr 5, 2021 100:01


This week we welcome Dr. Mansoor Mohammed. Mansoor is the president and chief scientific officer of The DNA Company and is considered to be a pioneer in medical genomics. He’s a classically trained molecular immunologist who has received academic and industry awards, published numerous papers, and holds patents in the general fields of molecular diagnostics and genomics research.  In this episode, we discuss the relationship of Functional Genomics and Epigenetics, both informing and transforming information on hormones from genetic testing, and Androgen Dominance and Estrogen Dominance. We also dive into the impact of oral contraceptives and their impact on genetic variances as well as, an in-depth breakdown of the three Estrogens and Estrogen Metabolism. Join The Better! Community On Facebook. Get the show notes here.

Psychopharmacology and Psychiatry Updates
Oral Contraceptives in Psychiatry: Potential Effects You Should Know

Psychopharmacology and Psychiatry Updates

Play Episode Listen Later Mar 19, 2021 6:43


Oral contraceptives can have an impact on mood in women with a history of depression. Can they also mimic the effects of chronic psychological stress? Faculty: Jim Phelps, M.D. Hosts: Jessica Diaz, M.D.; Flavio Guzman, M.D. Learn more about Premium Membership here Earn 0.5 CMEs: Quick Take Vol. 18 Evidence for Stress-Like Alterations in the HPA Axis in Women Taking Oral Contraceptives

Better with Dr. Stephanie
Nat Kringoudis on Educating Young Women On Menstruation, Sex and Their Bodies

Better with Dr. Stephanie

Play Episode Listen Later Mar 15, 2021 81:02


This week we welcome Nat Kringoudis. Nat is a Health-Care Practitioner, Author, Speaker, and all-around natural fertility expert. Nat is also a Two-Time Best Selling Author and recently released a new book called “Beautiful You”. In this episode, we discuss our role in helping educate young women on their period, about sex, and about connecting with their bodies. We also touch on issues surrounding oral contraceptives, and their effects on the body, libido, and sexuality. As well as how to approach children and young women about their cycle, and the first physical signs that menstruation is near. Join The Better! Community On Facebook. Get the show notes here.

Run Hard Mom Hard
44. Heidi Strickler on Nutrition for Female Athletes

Run Hard Mom Hard

Play Episode Listen Later Feb 19, 2021 110:17


This week we have a big resource episode coming your way! We talk with Heidi Strickler, a Registered Sports Dietitian who works with athletes world wide and specializes in female endurance athletes. Her mission is to help women understand how our bodies work, what is happening in our bodies during our cycles and how to fuel and train through all the changes we experience. Here are just some of the amazing takeaways from our time with Heidi! Your period is your superpower. It's a sign that your body is working as it should and there are ways to use your cycle as a tool nutritionally and athletically to perform optimally. The loss of a period is often the first sign that something isn't right in a woman's body. All food fits. We need to stop labeling food as bad or good which leads to us weighing our food choices in terms of morality. Obviously there are more nutritious foods than others, but you are not morally bad if you eat brownies, just as you are not morally good if you eat broccoli. Food is fuel. All bodies are good bodies - let's shift the narrative of “smaller is faster” and “smaller is better” because it can be but only until it isn't and it's a steep cliff to fall from when you're trying to achieve this societal standard. The goal is to re-establish body trust. We talk about the negative affects of Oral Contraceptives and how it can mask things like Relative Energy Deficiency in Sport and the problems RED-S can cause We can manage and mitigate symptoms during our cycle to feel and perform better. With tracking our body's natural rhythms we can understand the physiology of what is causing our symptoms. Heidi walks us through each phase of the cycle, how our hormones are being affected and tips on the foods we should focus on eating and the types of training that are most beneficial during each phase. SO enlightening! We talk about diet fads and fasted training and how they are male-centric and do not work for a woman's body. For nursing mothers: Heidi recommends the "See Food Diet", as in, if you see food, eat it! Heidi gives great tips on easy meals and snacks to make and pre-run, during-run and post-run fuel options! We as moms are role models for our kids - lets show them to respect their bodies by respecting ours! Thank you to this week's sponsor, Cadenshae! Cadenshae is a maternity activewear brand based out of New Zealand that makes medically endorsed maternity, postpartum and nursing apparel such as leggings, shorts, bras and tops! Check out their awesome products at cadenshae.com and use code RUNHARD15% for 15% off your purchase! Follow Heidi on Instagram Email her at hkstrickler.sportsrd@gmail.com Apps to track your cycle: Fitr Women Hello Clue Heidi loves UCAN products (more easily processed by womens' bodies than other sports nutrition brands!) Heidi's go-to meals during the week: burritos/tacos/fajitas/burrito bowls sheet pan meals crockpot meals: curry/stew/soup/chili or pulled pork/sloppy joes/pot roast burgers (salmon, beef, veggie, etc.) breakfast (scrambles, breakfast burritos, pancakes, frittatas) Go to the Podcast Write Up Article to see how Heidi structures her meals throughout the week! --- Send in a voice message: https://anchor.fm/run-hard-mom-hard/message

Psychopharmacology and Psychiatry Updates
Premenstrual Mood Syndromes: Oral Contraceptives in Psychiatry?

Psychopharmacology and Psychiatry Updates

Play Episode Listen Later Feb 2, 2021 9:25


Should psychiatrists prescribe oral contraceptives? What is the role of oral contraceptives in the treatment of PMDD? How do oral contraceptives work in premenstrual syndromes? Faculty: Lauren Osborne, M.D. Hosts: Jessica Diaz, M.D; Flavio Guzman, M.D. Learn more about Premium Membership here Earn 1 CME- "Premenstrual Mood Syndromes" Hormonal Treatments for Premenstrual Syndromes: Oral Contraceptives, GnRH Agonists, and Oophorectomy 

PVRoundup Podcast
Diabetic retinopathy associated with worse COVID-19 outcomes

PVRoundup Podcast

Play Episode Listen Later Jan 7, 2021 3:50


How does diabetic retinopathy affect COVID-19 outcomes? Find out about this and more in today’s PV Roundup podcast.

The Pelvic Health Podcast
Menstrual cycle and athletic performance with Dr. Kirsty Elliott-Sale

The Pelvic Health Podcast

Play Episode Listen Later Dec 31, 2020 53:49


What better way to start off 2021 with Associate Professor Dr. Kirsty Elliott-Sale discussing the #menstrual cycle and how sex #hormones may affect #exercise performance in the general female population. Dr. Elliott-Sale is the Head of the Musculoskeletal Physiology Research Group at Nottingham Trent University in England and lectures in the areas of Exercise Physiology, particularly in Female Physiology, Endocrinology, Performance, and Health. She has more than 20 years of experience working with females, elite female athletes and maternal populations including expertise in regards to the design and implementation of exercise-based interventions. Since the completion of her PhD, which examined the effects of female reproductive hormones on muscle strength, her research has concentrated on various aspects of health and athletic performance in female populations. In this episode we cover: the stages of the menstrual cycle – simplified so we all understand! (CLICK HERE AND HERE FOR MENSTRUAL CYCLE PHOTOS TO FOLLOW ALONG) if hormonal changes influence athletic performance whether the research supports females training according to their menstrual cycle How oral contraceptives change the picture She also recently recorded a brilliant podcast episode with BJSM so do not miss it – it’s a great compliment to this one!  Her Twitter account @ElliottSale Open Access Papers: McNulty, K.L., Elliott-Sale, K.J., Dolan, E. et al. The Effects of Menstrual Cycle Phase on Exercise Performance in Eumenorrheic Women: A Systematic Review and Meta-Analysis. Sports Med 50, 1813–1827 (2020). https://doi.org/10.1007/s40279-020-01319-3 Elliott-Sale, K.J., McNulty, K.L., Ansdell, P. et al. The Effects of Oral Contraceptives on Exercise Performance in Women: A Systematic Review and Meta-analysis. Sports Med 50, 1785–1812 (2020). https://doi.org/10.1007/s40279-020-01317-5 Listen and enjoy and a big thanks to Always Discreet for sponsoring this episode of The Pelvic Health Podcast. Head to Always Discreet to learn more about bladder leak tips, management and incredible bladder leakage protection!

KoopCast
Research Breakdown: Effects of Oral Contraceptives on Exercise with Coach Chantelle Robitaille | Koopcast Episode 57

KoopCast

Play Episode Listen Later Dec 10, 2020 62:07


In this episode of the podcast, we talk to CTS coach Chantelle Robitaille about a recent systematic review and meta-analysis on how oral contraceptive affects exercise. Paper Referenced:The Effects of Oral Contraceptives on Exercise Performance in Women: A Systematic Review and Meta-analysisInterested in coaching? Go visit www.trainright.com

BJSM
Time for a bloody good podcast. And yes, this one’s for men too. With Kirsty Elliott-Sale. Ep #457

BJSM

Play Episode Listen Later Dec 7, 2020 24:20


Dr. Kirsty Elliott-Sale. Dr. Elliott-Sale is an Associate Professor of female physiology at Nottingham Trent University in Nottingham, England, where she is Head of the Musculoskeletal Physiology Research Group. For over 20 years she has been focussed on elite women athletes and maternal populations, primarily in the areas of endocrinology and musculoskeletal and exercise physiology. In this episode, Dr. Erin Macri talks to Dr. Elliott-Sale about menstruation and oral contraception, and their effects on sports performance. This is an important listen for all men and women who work with women athletes of all levels. Twitter: @ElliottSale @Erin_Macri Resources and references Menstruation is not a taboo in women’s sport, period. https://theconversation.com/menstruation-is-not-a-taboo-in-womens-sport-period-92378 The BASES Expert Statement on Conducting and Implementing Female Athlete-Based Research https://www.bases.org.uk/imgs/0000_bas_tses___autumn_2020_online_pg6_7237.pdf McNulty, K.L., Elliott-Sale, K.J., Dolan, E. et al. The Effects of Menstrual Cycle Phase on Exercise Performance in Eumenorrheic Women: A Systematic Review and Meta-Analysis. Sports Med 50, 1813–1827 (2020). https://doi.org/10.1007/s40279-020-01319-3 Elliott-Sale, K.J., McNulty, K.L., Ansdell, P. et al. The Effects of Oral Contraceptives on Exercise Performance in Women: A Systematic Review and Meta-analysis. Sports Med 50, 1785–1812 (2020). https://doi.org/10.1007/s40279-020-01317-5 Martin, D., Sale, C., Cooper, S. B., & Elliott-Sale, K. J. (2018). Period Prevalence and Perceived Side Effects of Hormonal Contraceptive Use and the Menstrual Cycle in Elite Athletes, International Journal of Sports Physiology and Performance, 13(7), 926-932. Retrieved Dec 2, 2020, from https://journals-humankinetics-com.ezproxy.library.ubc.ca/view/journals/ijspp/13/7/article-p926.xml

Third Time's the Charm
Oral Contraceptives

Third Time's the Charm

Play Episode Listen Later Nov 10, 2020 0:45


This episode covers oral contraceptives!

Fuel The Pedal podcast
FTP #36: Kirsty Elliott-Sale & Eimear Dolan - The Female cyclist series: oral contraceptives and exercise performance

Fuel The Pedal podcast

Play Episode Listen Later Oct 12, 2020 74:37


On this second episode of this series dedicated exclusively to the female cyclist and endurance female athletes, we are talking again with Kirsty Elliott-Sale and Eimear Dolan about the role of oral contraceptive pills (OCPs) and exercise performance. This episode was based on a recent Meta-Analysis published by the guests themselves on Sports Medicine and they'll tell us what they found. Do OCP users have a lower performance when compared with naturally menstruating women? Is performance superior in OCP taking days vs. OCP withdrawal days? Tune in to find out.

The Messy Middle Podcast
LLR #4: Oral Contraceptives and Exercise Performance

The Messy Middle Podcast

Play Episode Listen Later Oct 8, 2020 25:46


Alyssa breaks down the research regarding how oral contraceptives may impact your exercise. Leave us a review and you could win a FREE Little Lyss product! Be sure to leave your Instagram handle in the review, or send a screenshot to @themessymiddlepodcast on Instagram! SOCIAL: Follow Alyssa on Instagram Follow Kait on Instagram Follow the podcast on Instagram SUPPORT US: Get your FREE 30 day Audible trial Get 20% off your first order of Legion Supplements with code: messymiddle Buy Lyss & Kait a cup of coffee --- Support this podcast: https://anchor.fm/the-messy-middle-podast/support

Female Athlete Podcast
Mapping your menstrual cycle, nutrition and can you exercise whilst on your period?

Female Athlete Podcast

Play Episode Listen Later Mar 27, 2020 43:54


We ask why and how to map your menstrual cycle, how to optimise your nutrition for different phases and we ask can you exercise whilst on your period? Plus Georgie, Jess and Lucy give their highlights and talking points from the past week in women's sport.*Please note this episode was recorded prior to the Coronavirus lockdown in the UK. We hope all our listeners wherever they may be are safe and well.*We have a dedicated question time at the end of each episode going forwards so if you have any questions please contact us on Twitter @female_pod or Instagram @femaleathletepodcast or email us your questions at femaleathletepodcast@gmail.com. Your question can be anonymous if you wish. We would love to hear from you!*Question time: 40 mins 14sTalking point links: Racing and training on your period: Recent interview with Jenny Tough following her Atlas Mountain Race win: https://www.apidura.com/journal/racing-and-training-on-your-period/ Griffith University: Practice Does Not Make Perfect: A Brief View of Athletes' Knowledge on the Menstrual Cycle and Oral Contraceptives: https://pubmed.ncbi.nlm.nih.gov/32089432/ Kim Clijsters begins comeback with a promising loss: https://www.nytimes.com/2020/02/17/sports/tennis/kim-clijsters-comeback.html

Itchy and Bitchy
Oral Contraceptives, Perimenopause and Leanne Has IUD Nostalgia

Itchy and Bitchy

Play Episode Listen Later Dec 28, 2019 25:05


Karen and Leanne talk about the effect of birth control pills on perimenopause. Leanne remembers the good ole days of having an IUD and learning to let it go. Follow us on Facebook: https://www.facebook.com/sweatyandpissed Instagram: @sweatyandpissed, @leannemorgancomedy, @wentzeland

GYN Corner
Oral Contraceptives part 2

GYN Corner

Play Episode Listen Later Dec 2, 2019 9:40


Today is the conclusion of the information provided during the last presentation on Oral Contraceptives, aka "Birth Control Pills." --- Send in a voice message: https://anchor.fm/dr-mcdaniel/message

GYN Corner
Oral Contraceptives

GYN Corner

Play Episode Listen Later Nov 28, 2019 9:14


Today we'll be discussing birth control pills, the ins and the outs. --- Send in a voice message: https://anchor.fm/dr-mcdaniel/message

The Optimal CEO
30: High Testosterone In Women Can Be A Huge Problem

The Optimal CEO

Play Episode Listen Later Oct 30, 2019 19:55


In this episode, I'll be sharing why some women have high testosterone and what kind of havoc it can wreak on their system when it occurs. When it comes to testosterone levels in women, there's a lot of confusion among women, and also among health professionals. In fact, many health professionals don't quite know what to do when a woman has elevated testosterone levels. Stay tuned as I explain why that happens by focusing on polycystic ovary syndrome and diabetes.Key Points Discussed:The silent epidemic that is polycystic ovary syndrome (01:51)The kind of havoc high testosterone can wreak on the female body (03:42)The hormone dysregulation related to insulin that causes irregular periods (06:34)How well oral contraceptives work for hormone balancing (09:17)Teaching women to be self advocates for themselves (12:58)Understanding the relationship between hormones, blood sugar and insulin, and vice versa (16:50)Additional Resources:www.BrianGBrown.comwww.BrianGBrown.com/Book--My new book will be releasing soon. Be sure to join the Inner Circle now!Happiness Hijackers Inner Circle: http://bit.ly/2wC9esW--To work with Dr. Brown, please visit: http://bit.ly/2Z6r9Ek--Be sure to follow us on Instagram and Facebook!--You can find the podcast on Apple, Google, Spotify, Stitcher, or wherever you listen to podcasts.If you haven't already, please rate and review the podcast on Apple: Podcasts!

The Genesis Zone with Dr Brian Brown
High Testosterone In Women Can Be A Huge Problem

The Genesis Zone with Dr Brian Brown

Play Episode Listen Later Oct 30, 2019 19:57


In this episode, I'll be sharing why some women have high testosterone and what kind of havoc it can wreak on their system when it occurs. When it comes to testosterone levels in women, there's a lot of confusion among women, and also among health professionals. In fact, many health professionals don't quite know what to do when a woman has elevated testosterone levels. Stay tuned as I explain why that happens by focusing on polycystic ovary syndrome and diabetes.Key Points Discussed:The silent epidemic that is polycystic ovary syndrome (01:51)The kind of havoc high testosterone can wreak on the female body (03:42)The hormone dysregulation related to insulin that causes irregular periods (06:34)How well oral contraceptives work for hormone balancing (09:17)Teaching women to be self advocates for themselves (12:58)Understanding the relationship between hormones, blood sugar and insulin, and vice versa (16:50)Additional Resources:www.BrianGBrown.comwww.BrianGBrown.com/Book--My new book will be releasing soon. Be sure to join the Inner Circle now!Happiness Hijackers Inner Circle: http://bit.ly/2wC9esW--To work with Dr. Brown, please visit: http://bit.ly/2Z6r9Ek--Be sure to follow us on Instagram and Facebook!--You can find the podcast on Apple, Google, Spotify, Stitcher, or wherever you listen to podcasts.If you haven't already, please rate and review the podcast on Apple: Podcasts!

The Hormone Lifestyle Zone
Episode #5: Oral Contraceptives: The Good. The Bad. The Truth.

The Hormone Lifestyle Zone

Play Episode Listen Later Aug 30, 2019


I firmly believe that every woman has the right to effective and accessible forms of birth control.  I also believe women need to receive full disclosure and informed consent before starting an oral contraceptive.    Oral Contraceptives hijack a woman's hormones allowing her reproductive system to be driven by synthetic chemicals that are associated with a laundry list of side effects that include: • Depression & Anxiety • Low libido  • Weight gain  • Delayed conception • Lower thyroid function • Worsening of PMS   Did you know that s woman's sense of smell is altered while on an oral contraceptive and can interfere with choosing the “right” partner?   Please join me for an interesting conversation about oral contraceptive, monthly energetic rhythms and why having a menstrual cycle is a power gift for all women.  Oh, I forgot to mention that PMS needn't be a part of the equation for ANY woman.

The Elective Rotation: A Critical Care Hospital Pharmacy Podcast
407: Drug interaction between sugammadex and oral contraceptives

The Elective Rotation: A Critical Care Hospital Pharmacy Podcast

Play Episode Listen Later Jun 13, 2019 2:30


Show notes at pharmacyjoe.com/episode407. In this episode, I’ll discuss the drug interaction between sugammadex and oral contraceptives. The post 407: Drug interaction between sugammadex and oral contraceptives appeared first on Pharmacy Joe.

Sports Mastery
133. Myths & Fallacies, Women & Strength Training pt. 2

Sports Mastery

Play Episode Listen Later Apr 16, 2019 35:33


EMILY PAPPAS, M.S. EXERCISE PHYSIOLOGY WHY is there a disparity of women in the weight room compared to men? It all derives from how women have been viewed in sport since the early 1900s. Why females view lifting as a guy thing stems from years and years of misinformation and cultivation of societal norms that are currently inhibiting our female athletes success. Emily brings to light these common myths: 1. Q angle, Hormones, and Injury risks ( Alluding it is due to a "structural deficiency" perpetuates a culture that assumes females are less fit for sport. When in fact SOME females have wider hips, some do not. ACL injuries were considered an epidemic 10 years after females were allowed to engage in sport under the NCAA umbrella....yet those females were not pushed to the weight room like men. Rather than explaining this epidemic as a structural or hormonal default, we need to consider the overall systemic strength of our female athletes). 2. Lifting makes you bulky: this statement is not only incorrect but fails to recognize the neurological adaptations gained in strength training (beyond a small amount of "mass") that aids in athletic performance 3. MISSED PERIODS ARE NORMAL FOR FEMALES: completely false and a disastrous mindset. Missing periods (outside of other health issues like PCOS) are defined by REDs as due to low energy availability. This could be a entire topic in itself talking about the relationship females have with food, fear of carbs, lack of protein, body composition anxiety, and how simple nutrition education is the key to helping solve these problems. 4. ORAL CONTRACEPTIVES:t o help regulate periods (again completely false and a misguided belief that could actually lead to long term low bone density as the female ages) 5. LIFTING TOO YOUNG IS DANGEROUS: this is a huge one that applies to males as well How we as coaches can help educate our parents, other coaches, and our athletes on the importance of strength training and how to create an environment that encourages females...   Emily Pappas holds a master's of science in Kinesiology & Exercise Physiology and is the founder of Relentless Athletics. Relentless is a company driven by science that specializes in the development of female athletes. Relentless consists of a team of passionate and well-educated female sport physiologists & athletic trainers who work to provide proper education and training centered around scientifically-based approaches to strength training, sports nutrition, and sports injury rehabilitation that is specific to the female athlete population. Emily R Pappas M.S. Exercise Physiology Founder of Relentless Athletics Adjunct at Temple University  

CorConsult Rx: Evidence-Based Medicine and Pharmacy
Podcast Ep 37: Oral Contraceptives

CorConsult Rx: Evidence-Based Medicine and Pharmacy

Play Episode Listen Later Oct 9, 2018 50:41


On this episode, we cover oral contraceptives. We review the mechanism of action and compare various formulations with the physiology of the menstrual cycle. We discuss various adverse effects that may be encountered and how to combat those effects. We also review the proper way of dealing with a missed-dose of an OC. Link to the article reviewing the mechanism of clot formation due to oral contraceptive : https://www.ebmconsult.com/articles/oral-contraceptive-clotting-factors-thrombosis-dvt-pe If you have any questions, reach out to us on any of the following: Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com Instagram and other social media platforms - @corconsultrx This podcast reviews current evidence-based medicine and pharmacy treatment options. This podcast is intended to be used for educational purposes only and is intended for healthcare professionals and students. This podcast is not for patients and not intended as advice or treatment.

Catholic Women Now
Adam Storey, Director of Marriage and Family joins us to discuss Humane Vitae

Catholic Women Now

Play Episode Listen Later Jul 26, 2018 27:56


It is the 50th year anniversary since the release of Human Vitae, Pope VI historical and prophetic encyclical on human sexuality and birth control. Adam Storey joins us to look at the four prophetic teachings that have now come to be over the past 50 years.

Catholic Women Now
Mary Scrimribba from Natural Womanhood

Catholic Women Now

Play Episode Listen Later Jul 19, 2018 28:46


Mary Scrimribba joins us to tell us more about Natural Womanhood. Its purpose to teach and educate the PIll literacy to women. Many do not know the harmful side effects of oral contraceptives. With science-backed facts, NaturalWomanhood reveals what women should consider when it comes to their reproductive health.

Dermatology Weekly
Oral Contraceptives for Acne Treatment: Prescribing Practices of US Dermatologists

Dermatology Weekly

Play Episode Listen Later Jun 12, 2018 13:38


In this edition of the "Peer to Peer" audiocast series, Dr. Vincent DeLeo speaks with Dr. Cynthia L. Chen about the prescribing practices of US dermatologists regarding oral contraceptives (OCPs) for acne treatment. Dr. Chen describes the results of a recent survey that was used to collect data about the demographics and practice settings of dermatologists who prescribe OCPs in the United States as well as how their knowledge and beliefs about OCPs inform their prescribing practices. She also discusses the use of 4th-generation drospirenone-containing OCPs, which have been shown to be slightly more effective for acne than other combined OCPs but also are associated with an increased risk of venous and thromboembolic events. Dr. Chen also explains her process for prescribing OCPs for acne treatment, including how to discuss the effects of hormonal treatments with patients.

Health Report - ABC RN
Fasting and fat cells, oral contraceptives, antibiotic surveys and macular degeneration research

Health Report - ABC RN

Play Episode Listen Later Dec 11, 2017 28:21


Health Quest Podcast with Steve Lankford
067 – Oral Contraceptives and Nutrient Depletion – My Interview with Ross Pelton

Health Quest Podcast with Steve Lankford

Play Episode Listen Later Jul 24, 2013 40:22


Birth control pills increase the risk for many health problems. Birth control pills are currently taken by over 12 million women in the United States and over 100 million women worldwide. Unfortunately, most don’t realize that taking birth control pills substantially increases the risk of having many health problems, some of which are potentially very […] The post 067 – Oral Contraceptives and Nutrient Depletion – My Interview with Ross Pelton appeared first on Health Quest Podcast.

Ben Greenfield Life
#236: Does The Pill Make You Gain Weight, How To Stop Leg Cramps, Are Earthing Mats Safe, and More!

Ben Greenfield Life

Play Episode Listen Later Apr 4, 2013 98:02


Click to Subscribe to All Ben's Fitness & Get A Free Surprise Gift from Ben. April 3, 2013 Podcast: Does the pill make you gain weight, are earthing mats safe, how to stop leg cramps and spasms, how to breathe the right way during exercise, are minimalist shoes ok for flat feet, how much protein should you eat during exercise, and natural remedies for strokes. Have a podcast question for Ben? Click the tab on the right side of this page, call 1-877-209-9439, Skype “pacificfit” or (if you hate the sound of your own voice) scroll down to the “Ask Ben” form. Please don't forget to give the podcast a comment/ranking in iTunes - it only takes a minute and it helps grow our healthy and fit community! ----------------------------------------------------- News Flashes: To get these and other interesting news flashes every week, follow Ben on Twitter.com/BenGreenfield, Facebook.com/BGFitness and Google+. One of the reasons why I think drinking milk is just fine (especially for athletes). Here's why single-speed, "junk mile" training is addictive. Think pot. Interesting. Control your inflammation to run a faster marathon! ----------------------------------------------------- Special Announcements: AudiblePodcast.com/Ben - sign up today and get your own copy of the audio book "A Game of Thrones: A Song of Ice and Fire, Book I" Get Ben's brand new "Essential Guide To Becoming Superhuman" at superhumancoach.com Lean Lifestyle Insider - For the past several weeks, one of my friends (Abel James Bascom AKA the “Fat Burning Man”) and I have been filming all the daily tips, tricks and tools we use to achieve maximum fat loss, lean muscle and optimized health and performance. Upcoming Inner Circle webinars - go to BenGreenfieldFitness.com/innercircle to get access: - April 6, Saturday, 6pm PST: "How To Raise Superhuman Kids" - April 27, Saturday, 6pm PST: "Ask Ben Anything About Minimalist Triathlon Training" Call in and leave your "low carb" question for our Jimmy Moore episode - by using the "Ask Ben A Question" option on right side of page or calling toll-free to 1-877-209-9439 and leaving a pre-recorded message. Superhuman Supplement Workshop ----------------------------------------------------- Listener Q&A: As compiled, edited and sometimes read by Brock, the Ben Greenfield Fitness Podcast "sidekick". Anonymous asks @ 00:27:31 Oral Contraceptives and weight gain? She has recently switched over to a new pill that is higher in estrogen (she was diagnosed with low estrogen) and is wondering if the weight gain is psychological or if there is something to it? ~ In my response, I recommend the books The Hormone Cure and The Pill. Avi says @ 00:39:12 He recently listened to the podcast episode you did with the creator of the Earth Pulse. He is wondering what the difference is between that and the earthing mat that Dave Asprey uses. There is a large cost difference but it sounds like they can be used in similar ways. ~ In my response, I reference the Earthpulse and Greenwave filters. Colin asks @ 00:49:04 Looking for supplements that will help with muscle spasms. He's been having trouble running downhill. His leg gets a sharp twinge in his vastus laterus/medialus and rectus femerus. If he limps for half a kilometre or so he is able to start shuffling again but he has to be very careful or the spasm will come back. ~ In my response to Colin, I mention: Transdermal magnesium, Trace minerals, Rumble Roller. Fred asks @ 00:56:52 He has been doing the Beach Body Insanity workouts and is wondering when they say to "engage your core" and "use those abs" what does that really mean? The people in the video seem to be sucking their guts way in but he is concerned that will impeded proper deep breathing. Do you have any guidance on how to "engage your abs" correctly. ~ In my response, I refer to the article How To Breathe The Right Way. Gabriel says @ 01:04:16 First he reminds us to wash our hands well after applying topical magnesium - especially before you touch your sore nipples. Second, he has flat feet and the running stores always recommend very heavy shoes with a lot of support but those shoes hurt his knees. He finds he runs best in very light shoes. What would you recommend for flat feet? ~ In my response to Gabriel, I mention www.skorarunning.com and How Start Running Barefoot. Matt asks @ 01:13:54 He has a lot of questions about protein: What are your thoughts on the use of soy protein in Hammer Nutrition's Perpetum (used instead of whey to avoid the overproduction of ammonia), during long endurance events what do you recommend that is both a good carb source mixed with a good protein source (UCAN Superstarch mixed with secondary protein?), also how much protein per hour do you recommend for a longer race (like an Ironman)? ~ In my response to Matt, I recommend the Master Amino Pattern. Stu wrote @ 01:22:29 I have a good mate who is recovering from a mild stroke, and I was wondering if you have covered this topic in a previous blog or podcast. What advice would you give in relation to nutrition and is there anything in particular that can improve his health? ~ In my response to Stu, I mention TianChi. I also recommend: D-Ribose, Coenzyme Q-10, Vitamin B6, Vitamin B12, Fish Oil, Ginkgo Biloba, Taurine, Vinpocetine. Prior to asking your question, do a search in upper right hand corner of this website for the keywords associated with your question. Many of the questions we receive have already been answered here at Ben Greenfield Fitness! ====================================== [contact-form-7 id="6222" title="Ask Ben"]======================================

The Lancet Infectious Diseases
The Lancet Infectious Diseases: December 22, 2011

The Lancet Infectious Diseases

Play Episode Listen Later Dec 22, 2011 18:34


January issue highlights, including the launch of a series on Mass Gatherings Medicine

Reproductive Biology
Side Effects of Oral Contraceptives for Women

Reproductive Biology

Play Episode Listen Later Dec 2, 2010 2:58


Reproductive Biology
Side Effects of Oral Contraceptives for Women

Reproductive Biology

Play Episode Listen Later Dec 2, 2010


Dr. Gwen's Women's Health Podcasts
Oral Contraceptives May Ease Suffering of Women with Severe PMS; Conflicting Messages on What to Eat When You're Pregnant

Dr. Gwen's Women's Health Podcasts

Play Episode Listen Later Sep 13, 2008 11:28


A new clinical trial at the University of North Carolina at Chapel Hill using a popular low-dose contraceptive could uncover a more effective treatment for the 5-10% of women who suffer from premenstrual dysphoric disorder (PMDD). Conflicting reports about safe levels of mercury in fish have a majority of pregnant women eliminating the food from their diet altogether. This study warns that decreased consumption of fish in childbearing, pregnant and lactating women, and young children may have detrimental consequences.

The Lancet
The Lancet: January 25, 2008

The Lancet

Play Episode Listen Later Jan 25, 2008 8:24


In this week's podcast Pam Das discusses the Editorial calling for oral contraceptives to be made more widely available to women 'over the counter'. This is in response to a study showing how long-term use of oral contraceptives is protective against ovarian cancer, discussed by Professor Valerie Beral (University of Oxford, UK).

The Lancet
The Lancet: November 09, 2007

The Lancet

Play Episode Listen Later Nov 9, 2007 29:41


Previous research has shown how women using oral contraceptives are at a small increased risk of cervical cancer. In this week's podcast Jane Green from the University of Oxford, UK, discusses how this risk returns to that of never-users of hormonal contraceptives ten years after cessation of use.

The Lancet
The Lancet: April 20, 2007

The Lancet

Play Episode Listen Later Apr 20, 2007 10:12


Professor Valerie Beral discusses the latest findings of the million women study. An estimated 1000 extra women in the UK have died from ovarian cancer between 1991 and 2005 because they were using Hormone Replacement Therapy.