Podcast appearances and mentions of gene drives

Moskitos können gefährliche Erreger verbreiten; mit der Erderwärmung wird das wohl noch schlimmer. Doch es gibt Lösungsansätze. Moskitos gelten als gefährlichste Tiere der Welt, denn sie können verschiedene Krankheiten übertragen: Malaria, Dengue, West-Nil-Fieber. Doch unter Laien gibt es auch übertriebene Mücken-Mythen. Unsere Kollegin Sarah Emminghaus hat Biologinnen und Arbovirologen in Hamburg und Berlin über die Schulter geschaut. Im Gespräch mit Host Lucie Kluth erklärt sie, warum nicht jede Mücke jeden Erreger verbreiten kann. Sie berichtet über die komplexe Beziehung zwischen Wirt, Vektor und Virus und über die Idee, Moskitos per Gentechnik unschädlich zu machen. Außerdem erfahren wir, weshalb es eine gute Idee ist, Mücken einzufrieren und nach Berlin zu schicken, warum man Gießkannen im Garten regelmäßig ausleeren sollte - und was Wattepads mit Fußgeruch im Sicherheitslabor zu suchen haben. HINTERGRUNDINFORMATIONEN Vorkommen und die Entwicklung Anopheles Plumbeus in Deutschland: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tmi.12805 Expertenkommission und Grafik zu aktueller Tigermücken-Verbreitung in Deutschland: https://www.fli.de/de/kommissionen/nationale-expertenkommission-stechmuecken-als-uebertraeger-von-krankheitserregern/ Zusammenhang zwischen Klimawandel und Arboviren in Aedes-Mücken anhand Beispiel aus Argentinien: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305058/ Bundesforschungsinstitut für Tiergesundheit zur Verbreitung des West-Nil-Virus: https://www.fli.de/de/aktuelles/tierseuchengeschehen/west-nil-virus/ Studie zum Überwintern des West-Nil-Virus in Deutschland: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703620/ Wolbachia-Studie aus Indien:  https://www.nejm.org/doi/full/10.1056/nejmoa2030243 Wolbachia-Studie aus Brasilien: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009556 Wolbachia-Studie aus Australien: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801363/ Artikel über den langen Weg hin zu Wolbachien gegen Dengue:   https://www.scientificamerican.com/article/how-a-tiny-bacterium-called-wolbachia-could-defeat-dengue/ WHO über den Zusammenhang zwischen den Klimawandel und dem Malaria-Risiko: https://www.who.int/news/item/30-11-2023-who-s-annual-malaria-report-spotlights-the-growing-threat-of-climate-change Studie über tagsüber stechende Moskitos in der Zentralafrikanischen Republik: https://pubmed.ncbi.nlm.nih.gov/35576470/ Studie über tagsüber stechende Moskitos nach der Nutzung von Bettnetzen: https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-125 Studie über die Funktionsweise der Gene Drives bei "Target Malaria": https://www.nature.com/articles/s41587-020-0508-1 Studie über sogenannte Daisy Chains: https://pubmed.ncbi.nlm.nih.gov/30940750/  Mehr Hintergrund zu dieser Folge: ndr.de/nachrichten/info/podcastsynapsen380.html Mehr Wissenschaft bei NDR Info: ndr.de/wissen

Moskitos können gefährliche Erreger verbreiten; mit der Erderwärmung wird das wohl noch schlimmer. Doch es gibt Lösungsansätze. Moskitos gelten als gefährlichste Tiere der Welt, denn sie können verschiedene Krankheiten übertragen: Malaria, Dengue, West-Nil-Fieber. Doch unter Laien gibt es auch übertriebene Mücken-Mythen. Unsere Kollegin Sarah Emminghaus hat Biologinnen und Arbovirologen in Hamburg und Berlin über die Schulter geschaut. Im Gespräch mit Host Lucie Kluth erklärt sie, warum nicht jede Mücke jeden Erreger verbreiten kann. Sie berichtet über die komplexe Beziehung zwischen Wirt, Vektor und Virus und über die Idee, Moskitos per Gentechnik unschädlich zu machen. Außerdem erfahren wir, weshalb es eine gute Idee ist, Mücken einzufrieren und nach Berlin zu schicken, warum man Gießkannen im Garten regelmäßig ausleeren sollte - und was Wattepads mit Fußgeruch im Sicherheitslabor zu suchen haben. HINTERGRUNDINFORMATIONEN Vorkommen und die Entwicklung Anopheles Plumbeus in Deutschland: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tmi.12805 Expertenkommission und Grafik zu aktueller Tigermücken-Verbreitung in Deutschland: https://www.fli.de/de/kommissionen/nationale-expertenkommission-stechmuecken-als-uebertraeger-von-krankheitserregern/ Zusammenhang zwischen Klimawandel und Arboviren in Aedes-Mücken anhand Beispiel aus Argentinien: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305058/ Bundesforschungsinstitut für Tiergesundheit zur Verbreitung des West-Nil-Virus: https://www.fli.de/de/aktuelles/tierseuchengeschehen/west-nil-virus/ Studie zum Überwintern des West-Nil-Virus in Deutschland: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703620/ Wolbachia-Studie aus Indien:  https://www.nejm.org/doi/full/10.1056/nejmoa2030243 Wolbachia-Studie aus Brasilien: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009556 Wolbachia-Studie aus Australien: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801363/ Artikel über den langen Weg hin zu Wolbachien gegen Dengue:   https://www.scientificamerican.com/article/how-a-tiny-bacterium-called-wolbachia-could-defeat-dengue/ WHO über den Zusammenhang zwischen den Klimawandel und dem Malaria-Risiko: https://www.who.int/news/item/30-11-2023-who-s-annual-malaria-report-spotlights-the-growing-threat-of-climate-change Studie über tagsüber stechende Moskitos in der Zentralafrikanischen Republik: https://pubmed.ncbi.nlm.nih.gov/35576470/ Studie über tagsüber stechende Moskitos nach der Nutzung von Bettnetzen: https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-125 Studie über die Funktionsweise der Gene Drives bei "Target Malaria": https://www.nature.com/articles/s41587-020-0508-1 Studie über sogenannte Daisy Chains: https://pubmed.ncbi.nlm.nih.gov/30940750/  Mehr Hintergrund zu dieser Folge: ndr.de/nachrichten/info/podcastsynapsen380.html Mehr Wissenschaft bei NDR Info: ndr.de/wissen

We have the choice to attack one of our oldest enemies with genetic engineering. But should we do it? Follow the show to join us in this audio experience of Kurzgesagt - In a Nutshell. A fan-made show out of admiration for the works of Kurzgesagt - In a Nutshell. Learn more about your ad choices. Visit megaphone.fm/adchoices

Binlerce yıldır Tanrıyı oynuyoruz. Daha yazı yazmayı bilmediğimiz zamanlardan beri, etrafımızdaki ekinleri ve hayvanları yapay seçilimle değiştiriyoruz. Ama artık oyunun kuralları değişiyor.Plan şu: Önce genetiğin aşırı kısa bir tarihi. Sonra, mucitlerine Nobel kazandıran CRISPR'ın anlam ve ehemmiyeti. Sonra da etik tartışmalar. Keyifli dinlemeler, hepinize ve patronlarıma teşekkürler. .Konular:(00:04) İtiraf: Ben bir genetik mühendisi değilim(01:30) Tanrıyı oynamak klişesi(03:50) Genetiği değiştirilmiş ilk hayvan(04:45) Genom dizilimi(07:25) CRISPR: Nobel ve ötesi.(14:20) Pratik uygulamalar(17:23) Gene Drive(20:15) İlk modifiye bebekler(21:20) İlk terapi: Orak hücre anemisi(21:55) Etik kaygıların fırsat maliyeti(24:30) Tasarım bebekler(27:00) Patent kavgası(28:45) Patreon Teşekkürleri..Kaynaklar:Video: CRISPR: Gene editing and beyondVideo: But what is CRISPR-Cas9Yazı: Oswald T Avery, the unsung hero of genetic scienceYazı: How CRISPR is making farmed animals bigger, stronger, and healthierYazı: Gene Editing Gold RushMakale: DNA synthesis technologies to close the gene writing gapMakale: The genome editing revolutionKitap: A Crack in CreationYazı: Gene Drives Could Fight MalariaHaber: His baby gene editing shocked ethicists. Now he's in the lab againYazı: We're entering a golden age of engineering biology.------- Podbee Sunar -------Bu podcast, Samsung hakkında reklam içerir.Samsung Galaxy S24/S24+ ve Galaxy S24 Ultra hakkında daha detaylı bilgi için tıklayınız.Bu podcast, Salus hakkında reklam içerir.Salus hakkında detaylı bilgi almak ve BASLANGIC10 koduyla %10 indirimden faydalanmak için tıklayınız.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Mr. Saurabh Todi, Research Analyst, High-Tech Geopolitics Programme, The Takshashila Institution, India Dr. Shambhavi Naik, Head of Research, The Takshashila Institution, India September 28, 2023 In this episode, we discuss advancements in gene drive capabilities and their potential as a tool to control vectors of zoonotic diseases. Gene drives are a natural process that preferentially propagates specific genetic traits through a population via sexual reproduction, and advances in genomic engineering have enabled scientists to harness this capability to target specific traits for spread in specific populations. They are best suited for use in animals that have short reproductive cycles and produce a large number of offspring, making them impractical for humans but immensely powerful for insects. Gene drives are being investigated as a tool to control mosquitoes' ability to procreate or their susceptibility to infections that could then spread to animals and humans, as a way to control diseases like malaria. Mr. Todi and Dr. Naik discuss the potential benefits of these capabilities, as well as barriers, costs, risks, and other considerations that factor into decisions regarding their future use.

Robotic Relief as Parents Tackle Tidy-up Turmoil with Tech.  Footsteps in Forensics as UK Leaps into Advanced Footwear ID Tech.  Revolutionary Robot Constructs Colossal Stone Walls.  Atari's Amazing Comeback as Retro Reboot Rocks Gaming World.  Tesla Triumphs Again with the 2024 Magnificent Model 3 Marvel.  Sniffing Success as Electronic Noses Tackle Food Safety.  Cunning Cats and CRISPR: Tackling Australia's Invasive Species with Gene Drives.  Squidgy Steps: Revolutionising Robotics with TRACEPaw Feet.  Small Scale, Big Impact: The Evolving World of Nuclear Reactors. 

Activist, Frances Micklem, and former Deputy Minister of Indonesia, Richard Claproth, join the program to discuss the massive mosquito program that has been unleashed in 12 countries. They share what they know about the program and how it is affecting the local residents. We also discuss how the WHO amendments and the full treaty will enable the WHO to implement programs like this one in every member country without your knowledge or consent. You can sign the petition to help stop this insanity at https://forms.gle/r3894kP2HnpRawFRA   Mentioned in the show: Find the ultimate list of Prepper and Unique Christmas gifts at https://sarahwestall.com/unique-christmas-gifts/ Help rebuild America and your independence - learn more at https://FreedomBuyingClub.com Consider subscribing: Follow on my Substack at SarahWestall.Substack.com Follow on Twitter at https://twitter.com/sarah_westall See Important Proven Solutions to Keep Your from getting sick even if you had the mRNA Shot - Dr. Nieusma MUSIC CREDITS: “In Epic World” by Valentina Gribanova, licensed for broad internet media use, including video and audio       See video on Bastyon | Bitchute | Rumble | Odysee | Youtube | Freedom.Social   Richard Claproth Biography Richard Claproth  received a PhD in Earth Science from the University of Wollongong, Australia . He also completed a Post-graduate Fellowship at the John F. Kennedy School of Government, Harvard University  and  he was appointed Assistant Coordinating Minister for Economics, Finance and Industry, and became Deputy Coordinating Minister for Economics, Finance and Industry. After returning from the United States, where he was a visiting Professor for Economics in the Post Graduate Program of the International Economics Graduate School at Brandeis University, he served as Secretary to the Minister for State-Owned Enterprises (MSOE) and also served as a member of State Defense Institute Economics Team (Lemhanas). In 2005 he was appointed Commissioner of Bank Mandiri. He has been received a number of honors in the course of his service with the Indonesian government, including the Satya Lencana Karya Satya 10 Tahun in 1993, the Satya Lencana Wira Karya in 1996 and the Bintang Jasa Pratama in 1998. He is the Founder of Forum Gladiator Bangsa, with a mission to share experiences from global leaders to nurture future leaders in Indonesia and worldwide.   Frances Micklem Biography Frances Micklem worked with the Institute for Responsible Technology in 2021, on drafting and sharing legislative reports, on the challenges of regulating Gene Edited Micro-organisms. Her research included the biosafety and health challenges of Gain of Function, Gene Drives, Biological Weapons, Green Technologies, Carbon Capture and Storage, gene edited Ingredients in food and Agriculture, GE Mosquitoes, GM Trees. The risks of even one modified microorganism persisting in Nature and inadvertently editing the fungal, bacterial and viral microbiomes on which life depend were found to be very high. The main challenge to regulation was Intellectual Property privacy, to protect military and trade value, while making public or independent risk assessment impossible. Governments had been lobbied, by the Pharmaceutical and Biotech Industry to grant exemptions from risk assessing genetically engineered organisms as invasive species. Environmental protection agencies were told to use old chemical contamination protocols instead, which do not take into account the spread of living organisms. Infant genetic engineering technologies, including CRISPR and micro-injection were promoted as natural and non-GMO.    

This is a selection of highlights from episode #164 of The 80,000 Hours Podcast.These aren't necessarily the most important, or even most entertaining parts of the interview — and if you enjoy this, we strongly recommend checking out the full episode:Kevin Esvelt on cults that want to kill everyone, stealth vs wildfire pandemics, and how he felt inventing gene drivesAnd if you're finding these highlights episodes valuable, please let us know by emailing podcast@80000hours.org.Highlights put together by Simon Monsour, Milo McGuire, and Dominic Armstrong

"Imagine a fast-spreading respiratory HIV. It sweeps around the world. Almost nobody has symptoms. Nobody notices until years later, when the first people who are infected begin to succumb. They might die, something else debilitating might happen to them, but by that point, just about everyone on the planet would have been infected already. And then it would be a race. Can we come up with some way of defusing the thing? Can we come up with the equivalent of HIV antiretrovirals before it's too late?" — Kevin EsveltIn today's episode, host Luisa Rodriguez interviews Kevin Esvelt — a biologist at the MIT Media Lab and the inventor of CRISPR-based gene drive — about the threat posed by engineered bioweapons.Links to learn more, summary and full transcript.They cover:Why it makes sense to focus on deliberately released pandemicsCase studies of people who actually wanted to kill billions of humansHow many people have the technical ability to produce dangerous virusesThe different threats of stealth and wildfire pandemics that could crash civilisationThe potential for AI models to increase access to dangerous pathogensWhy scientists try to identify new pandemic-capable pathogens, and the case against that researchTechnological solutions, including UV lights and advanced PPEUsing CRISPR-based gene drive to fight diseases and reduce animal sufferingAnd plenty more.Producer and editor: Keiran HarrisAudio Engineering Lead: Ben CordellTechnical editing: Simon MonsourAdditional content editing: Katy Moore and Luisa RodriguezTranscriptions: Katy Moore

Looking 4 Healing Radio with Dr. Henry Ealy – In this Looking 4 Healing Radio episode, Dr. H drops a bombshell for everyone… Blue Light. Over the weekend, Dr. H found proof that Blue Light emitting from Computer Screens, SMART Phones, TVs, LED Lights, and other sources activates CRISPR transhumanistic, genetic engineering technology known as Gene Drive. Blue Light is what activates CRISPR tech…in addition to giving you...

Looking 4 Healing Radio with Dr. Henry Ealy – In this Looking 4 Healing Radio episode, Dr. H drops a bombshell for everyone… Blue Light. Over the weekend, Dr. H found proof that Blue Light emitting from Computer Screens, SMART Phones, TVs, LED Lights, and other sources activates CRISPR transhumanistic, genetic engineering technology known as Gene Drive. Blue Light is what activates CRISPR tech…in addition to giving you...

Today I interview Prof. Kevin Esvelt of the MIT media lab. Coming from George Church's lab, Kevin was part of the discovery of Crispr, and the inventor of the Crispr based gene drive. He has become deeply involved in the prevention of existential risks.

À l'occasion du Congrès Francophone d'Allergologie, nous faisons un point sur ce dérèglement du système immunitaire. Les allergies correspondent à une hypersensibilité de l'organisme à des substances a priori inoffensives : les allergènes. Selon l'Inserm, 20 à 30 % de la population est concernée par une maladie allergique. Pouvant se manifester par des réactions cutanées, respiratoires ou généralisées, les allergies peuvent être traitées. Comment diagnostiquer l'allergie et identifier l'allergène ? Comment expliquer le développement d'une allergie ? Quelles sont les prises en charge existantes ? Dr Sarah Court Devilliers, allergologue à Dijon. Membre du Bureau fédéral de l'Association Nationale de Formation Continue des Allergologues (ANAFORCAL), VP DPC et chargée de communication ; membre du Conseil d'administration de la Fédération Internationale ANAFORCAL, qui regroupe toutes les associations francophones de médecins allergologues. Membre du groupe presse du Congrès francophone d'allergologie, qui se déroule du 25 au 28 avril au Palais des Congrès de Paris Dr Julienne Teclessou, dermato-vénérologue allergologue au CHU Campus de Lomé au Togo et maitre-assistante à la Faculté des Sciences de la Santé de l'Université de Lomé. ► En fin d'émission, à l'occasion de la Journée mondiale de lutte contre le paludisme, nous dressons un bilan de l'avancée de la recherche avec Amélie Wamba, coordinatrice du projet Gene Drive à l'Association panafricaine de contrôle des moustiques (PAMCA), en partenariat avec RBM - pour en finir avec le paludisme, la plus grande plateforme mondiale de coordination des actions contre le paludisme avec plus de 500 partenaires (pays impaludés, acteurs du secteur privé, ONG, fondations, universités…). ► À écouter aussi : Priorité Santé - Paludisme, les enfants particulièrement vulnérables.

À l'occasion du Congrès Francophone d'Allergologie, nous faisons un point sur ce dérèglement du système immunitaire. Les allergies correspondent à une hypersensibilité de l'organisme à des substances a priori inoffensives : les allergènes. Selon l'Inserm, 20 à 30 % de la population est concernée par une maladie allergique. Pouvant se manifester par des réactions cutanées, respiratoires ou généralisées, les allergies peuvent être traitées. Comment diagnostiquer l'allergie et identifier l'allergène ? Comment expliquer le développement d'une allergie ? Quelles sont les prises en charge existantes ? Dr Sarah Court Devilliers, allergologue à Dijon. Membre du Bureau fédéral de l'Association Nationale de Formation Continue des Allergologues (ANAFORCAL), VP DPC et chargée de communication ; membre du Conseil d'administration de la Fédération Internationale ANAFORCAL, qui regroupe toutes les associations francophones de médecins allergologues. Membre du groupe presse du Congrès francophone d'allergologie, qui se déroule du 25 au 28 avril au Palais des Congrès de Paris Dr Julienne Teclessou, dermato-vénérologue allergologue au CHU Campus de Lomé au Togo et maitre-assistante à la Faculté des Sciences de la Santé de l'Université de Lomé. ► En fin d'émission, à l'occasion de la Journée mondiale de lutte contre le paludisme, nous dressons un bilan de l'avancée de la recherche avec Amélie Wamba, coordinatrice du projet Gene Drive à l'Association panafricaine de contrôle des moustiques (PAMCA), en partenariat avec RBM - pour en finir avec le paludisme, la plus grande plateforme mondiale de coordination des actions contre le paludisme avec plus de 500 partenaires (pays impaludés, acteurs du secteur privé, ONG, fondations, universités…). ► À écouter aussi : Priorité Santé - Paludisme, les enfants particulièrement vulnérables.

The modern era of genetic engineering has opened tremendous opportunities in medicine and agriculture. But who governs when the technology should be applied? Similar questions were asked in the 1970s at the dawn of recombinant DNA technology. In his new book As Gods - A Moral History of the Genetic Age, Prof. Matthew Cobb discusses these watershed moments in molecular biology, and discusses his views on the newest applications in gene drives, human germline gene editing, and gain-of-function research. Purchase at Amazon

Why biology, why now? How will it transform our world? How do we create policies and regulation to ensure we advance biotechnology responsibly and protect our shared biological futures.  In our first interview, we speak with Megan Palmer who leads Stanford's Bio Policy and Leadership Initiatives in their Department of Bioengineering. Grow Everything brings to life the bioeconomy when hosts Karl Schmieder and Erum Azeez Khan share stories from the field and interview leaders and influencers in the space.  Life is a powerful force and it can be engineered. What are we creating? IN THIS EPISODE, YOU'LL LEARN: 00:00 Introduction 01:47 Why it's an exciting time to be in biotechnology 03:50 The intersection between policy, ethics, and government in biotechnology 05:52 Executive order on advancing biotechnology 07:12 Biotech and why it matters 09:05 Megan's origin story 13:17 Megan's experience working with government agencies 15:20 Working with policymakers globally and in the US 17:00 Understanding biotechnology innovation policies globally 21:39 The good and the bad of bureaucracy 24:00 What is a Gene Drive? 32:06 iGEM and other social responsibility programs 35:01 Community impacts and the birth of Bio stories 40:21 Imagine a world where everyone can build with biology 43:04 Parting thoughts Episode Links: Bioeconomy Executive Order Call or Text the Grow Everything Hotline:  +1 804-505-5553 Have a question or comment? Message us here: Email: groweverything@messaginglab.com Instagram: https://www.instagram.com/groweverythingpod/ TikTok: https://www.tiktok.com/@groweverythingpod Twitter: https://twitter.com/messaginglab LinkedIn: https://www.linkedin.com/company/messaginglab/ Youtube: https://www.youtube.com/channel/UCyfFwKFgFVMfEz4VWYwL4fg GrowEverything website:https://www.messaginglab.com/groweverything Topics: synthetic biology, entrepreneurship, policy, community, education, biotech, life sciences, bioeconomy, biomanufacturing, Biotechnology, synthetic biology, the biotech century, world economic forum Music by: Nihilore Production by: Amplafy Media --- Send in a voice message: https://podcasters.spotify.com/pod/show/messaginglab/message

Sogenannte Gene Drives sind spezielle Genveränderungsmethoden, die es Wissenschaftlern zum ersten Mal erlauben die Grenzen der klassischen Evolution nach Darwin zu sprengen und ihr Grundprinzip, die natürliche Selektion zu überwinden, in dem sie die Expression in allen Nachkommen erzwingen. In dieser Episode unterhalten sich Andreas Horchler und Louise von Stechow darüber wie Gene Drives in der Malariaprävention, in der Bewahrung bedrohter Arten und zur Erhöhung von Ernteerträgen eingesetzt werden könnten – und wie gefährlich diese Technologie in der Hand eines einzelnen Wissenschaftlers sein kann.

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: The Future Perfect 50, published by Catherine Low on October 23, 2022 on The Effective Altruism Forum. I just saw that Future Perfect have a new feature. I found it really inspiring so I thought I'd share it here. It is the Future Perfect 50: The scientists, thinkers, scholars, writers, and activists building a more perfect future.There are some wonderful profiles of people that will be familiar to many Forum readers, like Leah Garcés' work with farmers, Lucia Coulter and Jack Rafferty's work on Lead Elimination and Kevin Esvelt's Gene Drive research. But there are a host of inspiring people and stories I've never heard before, like Setusko Thurlow's anti-nuclear weapon work, Joy Buolamwini's algorithmic justice campaign, and Olga Kikou's fight for a ban on all caged farming in the EU. Thanks for listening. To help us out with The Nonlinear Library or to learn more, please visit nonlinear.org.

Die Malaria ist die häufigste Infektionskrankheit weltweit. 230 Millionen Menschen erkranken jährlich daran, über 400.000 Menschen sterben, vor allem Kinder. Bisher gibt es keinen durchschlagenden Erfolg bei der Bekämpfung. Neue Ansätze greifen nicht den Malaria-Erreger direkt an, sondern seine Überträger: Die Moskitos. Dabei werden Killergene in die Insekten übertragen. Ohne Moskitos keine Malaria, so der Plan. Im BiOfunk betrachten wir diesen genetischen Trick, den sogenannten Gene Drive. Welche Chancen bietet er, und welche Gefahren? Weitere Infos auf www.BiOfunk.net

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Gene drives: why the wait?, published by Metacelsus on September 19, 2022 on LessWrong. (Crossposted from my Substack) If you've been following biology news over the last few years, you might have heard of an interesting concept called a “gene drive”. The overall idea is to engineer a genetic allele that transmits itself to all offspring of a sexually reproducing organism, instead of being inherited by 50% as usual. This allele can also perform some other biological function (a relevant example is causing female sterility). A gene drive spreads through a population. From Esvelt et al. 2014 (CC-BY) In multiple trials, modern CRISPR-based gene drives have shown high efficacy in spreading through populations of caged Anopheles mosquitoes and completely suppressing their reproduction. Since Anopheles mosquitoes are the only ones that transmit malaria, causing their extinction would directly save hundreds of thousands of lives per year. Similar gene drives targeted to other types of mosquitoes (Aedes, Culex, etc.) could also eliminate diseases such as dengue fever, Zika virus, and West Nile virus. However, in spite of promising laboratory trials, gene drives have not yet been deployed in the wild. But why not? History of gene drives Although the technology to build effective gene drives did not exist until recently, the idea has been around for a while. In fact, gene drives occur naturally. Some well-known examples are transposons in flies, homing endonucleases in algae, and segregation distorters in mice. The idea of engineering a site-specific nuclease as a gene drive was developed as early as 2003, and in the decade that followed there were several efforts to develop these, with the labs of Austin Burt and Andrea Crisanti taking a lead role. These early systems showed some biased inheritance, but were not stable for more than a few generations. The advent of CRISPR as a gene editing system opened up a new opportunity. A paper in 2014 by Kevin Esvelt and co-workers proposed Cas9 as a nuclease for a gene drive, with several properties making it ideal for the task. It lacks repetitive sequences that caused problems with earlier gene drives using zinc-finger nucleases or TALENs. It has a very high efficiency of cutting. It is easy to target a new site by simply changing the guide RNA. Several nearby sites could be targeted at once, using different guide RNAs. From Esvelt et al. 2014 (CC-BY) CRISPR-based gene drives quickly gained popularity in the field, and by 2018 the Crisanti lab had demonstrated a working gene drive that could efficiently suppress populations of Anopheles gambiae by targeting an exon of the doublesex gene required for female development. At the time this was announced, I was studying at the University of Cambridge, and attended a public lecture by Prof. Crisanti about his lab's work. The overall mood in the room was almost euphoric: here was a technology that could save millions of lives, the best thing since Borlaug's wheat! Since that lecture, about 2 million people, mostly children in Africa, have died of malaria. Gene drive research has not stood still: the Crisanti lab tested their doublesex drive in larger cages of mosquitoes, and it again completely eliminated the populations. But given the millions of lives at stake, what's taking so long for this gene drive to be released? See also: the battle against malaria in Africa has stalled Why the wait? There are two good arguments against the immediate release of gene drives to eliminate mosquitoes. First, nuclease gene drives have the possibility of generating resistant alleles, making future gene drives not work against the same target. Therefore, it's important to get it right the first time, otherwise the potential of gene drives could be wasted. The goal of the large cage trials I mentioned earli...

Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Gene drives: why the wait?, published by Metacelsus on September 19, 2022 on LessWrong. (Crossposted from my Substack) If you've been following biology news over the last few years, you might have heard of an interesting concept called a “gene drive”. The overall idea is to engineer a genetic allele that transmits itself to all offspring of a sexually reproducing organism, instead of being inherited by 50% as usual. This allele can also perform some other biological function (a relevant example is causing female sterility). A gene drive spreads through a population. From Esvelt et al. 2014 (CC-BY) In multiple trials, modern CRISPR-based gene drives have shown high efficacy in spreading through populations of caged Anopheles mosquitoes and completely suppressing their reproduction. Since Anopheles mosquitoes are the only ones that transmit malaria, causing their extinction would directly save hundreds of thousands of lives per year. Similar gene drives targeted to other types of mosquitoes (Aedes, Culex, etc.) could also eliminate diseases such as dengue fever, Zika virus, and West Nile virus. However, in spite of promising laboratory trials, gene drives have not yet been deployed in the wild. But why not? History of gene drives Although the technology to build effective gene drives did not exist until recently, the idea has been around for a while. In fact, gene drives occur naturally. Some well-known examples are transposons in flies, homing endonucleases in algae, and segregation distorters in mice. The idea of engineering a site-specific nuclease as a gene drive was developed as early as 2003, and in the decade that followed there were several efforts to develop these, with the labs of Austin Burt and Andrea Crisanti taking a lead role. These early systems showed some biased inheritance, but were not stable for more than a few generations. The advent of CRISPR as a gene editing system opened up a new opportunity. A paper in 2014 by Kevin Esvelt and co-workers proposed Cas9 as a nuclease for a gene drive, with several properties making it ideal for the task. It lacks repetitive sequences that caused problems with earlier gene drives using zinc-finger nucleases or TALENs. It has a very high efficiency of cutting. It is easy to target a new site by simply changing the guide RNA. Several nearby sites could be targeted at once, using different guide RNAs. From Esvelt et al. 2014 (CC-BY) CRISPR-based gene drives quickly gained popularity in the field, and by 2018 the Crisanti lab had demonstrated a working gene drive that could efficiently suppress populations of Anopheles gambiae by targeting an exon of the doublesex gene required for female development. At the time this was announced, I was studying at the University of Cambridge, and attended a public lecture by Prof. Crisanti about his lab's work. The overall mood in the room was almost euphoric: here was a technology that could save millions of lives, the best thing since Borlaug's wheat! Since that lecture, about 2 million people, mostly children in Africa, have died of malaria. Gene drive research has not stood still: the Crisanti lab tested their doublesex drive in larger cages of mosquitoes, and it again completely eliminated the populations. But given the millions of lives at stake, what's taking so long for this gene drive to be released? See also: the battle against malaria in Africa has stalled Why the wait? There are two good arguments against the immediate release of gene drives to eliminate mosquitoes. First, nuclease gene drives have the possibility of generating resistant alleles, making future gene drives not work against the same target. Therefore, it's important to get it right the first time, otherwise the potential of gene drives could be wasted. The goal of the large cage trials I mentioned earli...

Found My Fitness - Rhonda Patrick Podcast Notes Key Takeaways CRISPR is a subset of editing; editing is a subset of genome engineering; genome engineering is gene therapy“Shrinking our agricultural use, possibly by 10 or 100 fold is feasible to do with synthetic biology and other new tools.” – Dr. George ChurchAdvances in reading and writing DNA double at least once per year; most of the exponential increase has occurred in the last 10-20 yearsCons of synthetic biology: lack of equity in access to technology and treatments; head in the sand approach to new technologies – FDA does not review; ethical considerationsPreventive medicine in genetics: genetic counseling preconception would be helpful to understand the future of offspring (as opposed to spending millions over a lifetime in gene therapy if disease is present)Aging studies in dogs (as opposed to rodents) are good parallel to outcomes in humans because they're large, live in human environments, have similar emotions, and bonding“What's natural is a moving target – a lot of things that were demonized or villainized in the past are now taken for granted, for example, some of us might remember how cell phones with were demonized as melting your brain or getting radiation to your brain.” – Dr. George ChurchGene editing therapy has the potential to reduce medical load, improve agriculture, alleviate some poverty burden (if there's less disease), eliminate disease animal-human transmission, eliminate or reduce germline diseaseThere is no way to have zero risk – status quo is risky, but we should start small in animal studies and then progress to human studiesRead the full notes @ podcastnotes.orgGeorge Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology.  In this episode, we discuss: 07:13 - History of the Human Genome Project 15:20 - Manufacturing cell phones (with biology) 17:34 - Genome Project-Write 20:03 - Writing a human Y chromosome (from scratch) 20:48 - What if you could eliminate viral disease? 22:51 - De-extinction and reinstating lost traits and genes 27:06 - The Vertebrate Genomes Project 29:47 - AlphaFold and other AI tools 41:27 - CRISPR vs. Base Editing (emerging tools of genetic engineering) 49:40 - Why multiplex editing will change the world 52:18 - Molecular flight recorder 53:31 - Preventing viral spillover and enhancing livestock 57:40 - PCSK9 gene therapy for cholesterol 01:00:30 - Is aging an evolved program? 01:05:21 - Treating aging with a combination gene treatment 01:09:04 - Does animal research help us understand human aging? 01:11:40 - Human organoids as a model and therapeutic 01:13:34 - Could engineered transplant organs become better than the originals? 01:16:17 - Embryo editing controversy 01:28:41 - Gene editing for space travel 01:30:40 - Can synthetic biology alleviate poverty? 01:34:07 - Is in vitro fertilization and embryo selection practically similar to editing? 01:39:12 - The occasional cost of brilliance 01:45:45 - Eradicating disease with Gene Drive 01:48:55 - Technologies to solve Lyme disease 01:51:57 - Dr. Church's experience with narcolepsy as a bridge to creative insights 02:00:42 - Why George encoded his book in DNA Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Found My Fitness - Rhonda Patrick: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology.  In this episode, we discuss: 07:13 - History of the Human Genome Project 15:20 - Manufacturing cell phones (with biology) 17:34 - Genome Project-Write 20:03 - Writing a human Y chromosome (from scratch) 20:48 - What if you could eliminate viral disease? 22:51 - De-extinction and reinstating lost traits and genes 27:06 - The Vertebrate Genomes Project 29:47 - AlphaFold and other AI tools 41:27 - CRISPR vs. Base Editing (emerging tools of genetic engineering) 49:40 - Why multiplex editing will change the world 52:18 - Molecular flight recorder 53:31 - Preventing viral spillover and enhancing livestock 57:40 - PCSK9 gene therapy for cholesterol 01:00:30 - Is aging an evolved program? 01:05:21 - Treating aging with a combination gene treatment 01:09:04 - Does animal research help us understand human aging? 01:11:40 - Human organoids as a model and therapeutic 01:13:34 - Could engineered transplant organs become better than the originals? 01:16:17 - Embryo editing controversy 01:28:41 - Gene editing for space travel 01:30:40 - Can synthetic biology alleviate poverty? 01:34:07 - Is in vitro fertilization and embryo selection practically similar to editing? 01:39:12 - The occasional cost of brilliance 01:45:45 - Eradicating disease with Gene Drive 01:48:55 - Technologies to solve Lyme disease 01:51:57 - Dr. Church's experience with narcolepsy as a bridge to creative insights 02:00:42 - Why George encoded his book in DNA Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology.  In this episode, we discuss: 07:13 - History of the Human Genome Project 15:20 - Manufacturing cell phones (with biology) 17:34 - Genome Project-Write 20:03 - Writing a human Y chromosome (from scratch) 20:48 - What if you could eliminate viral disease? 22:51 - De-extinction and reinstating lost traits and genes 27:06 - The Vertebrate Genomes Project 29:47 - AlphaFold and other AI tools 41:27 - CRISPR vs. Base Editing (emerging tools of genetic engineering) 49:40 - Why multiplex editing will change the world 52:18 - Molecular flight recorder 53:31 - Preventing viral spillover and enhancing livestock 57:40 - PCSK9 gene therapy for cholesterol 01:00:30 - Is aging an evolved program? 01:05:21 - Treating aging with a combination gene treatment 01:09:04 - Does animal research help us understand human aging? 01:11:40 - Human organoids as a model and therapeutic 01:13:34 - Could engineered transplant organs become better than the originals? 01:16:17 - Embryo editing controversy 01:28:41 - Gene editing for space travel 01:30:40 - Can synthetic biology alleviate poverty? 01:34:07 - Is in vitro fertilization and embryo selection practically similar to editing? 01:39:12 - The occasional cost of brilliance 01:45:45 - Eradicating disease with Gene Drive 01:48:55 - Technologies to solve Lyme disease 01:51:57 - Dr. Church's experience with narcolepsy as a bridge to creative insights 02:00:42 - Why George encoded his book in DNA Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Welcome to Cosmos Science Daily, where journalists from the Cosmos newsroom report on the latest research and discoveries and explain the science behind the headline news. Today's newsroom journalist and chemistry whiz, Ellen Phiddian, is talking about gene drives and feral cats, with your host, Dr Sophie Calabretto, applied mathematician and fluid mechanist who, appropriately, thinks feral cats are bad.Find the science of everything at the Cosmos Magazine websiteSubscribe to Cosmos Magazine (print) or the Cosmos WeeklyWatch and listen to all our Cosmos BriefingsSpecial 10% discount on Cosmos magazine print subscriptions (1 or 2 year), or 1 year Cosmos Weekly subscriptions for Cosmos Briefing podcast listeners!  Use coupon code COSMOSPOD in our shop.

Episode 1785 - What is Gene Drive? How many generations does it take to change the genome of the planet as in Genesis 6? Is America beyond redemption ? Will there be another plandemic in the fall? Will mail in ballots be used again? Will there be more election fraud? In Australia are newly born infants from injected women having severe respiratory issues? Ted and Sharon visited Noah's Ark yesterday Ted reviews the movie Elvis. Are banks having liquidity issues? Wow what a green show today! Must listen high energy.

In this episode Jeffrey discusses one of the most precarious and risky forms of Genetic Engineering called Gene Drives.  In Gene Drives scientists and engineers can introduce a genetic trait in a population and that genetic trait can quickly spread through the offspring of that population causing massive changes and even death to an entire species.   The Institute for Responsible Technology is working to protect you & the World from GMOs (and while we're at it, Roundup®...)  To find out exactly how we do this and to subscribe to our newsletter visit https://www.responsibletechnology.org/ Join us at Protect Nature Now to Safeguarding Biological Evolution from GMOs 2.0. The place to get critical up to date information, watch our short film and most importantly, learn easy ways for you to take action against this existential threat. Visit: https://protectnaturenow.com/ Watch "Don't Let the Gene Out of the Bottle" Get the book: "Seeds of Deception" Sign the Petition https://protectnaturenow.com/signthepetition/ IG @irtnogmos Facebook @responsibletechnology YouTube @TheInstituteforResponsibleTechinology Twitter @TheInstituteforResponsibleTechnology  

Jonathan Latham on Gene Drives and the Gates Foundation - Corbett Report: Interview 1551 www.corbettreport.com/ The Corbett Report is an independent, listener-supported alternative news source. It operates on the principle of open source intelligence and provides podcasts, interviews, articles and videos about breaking news and important issues from 9/11 Truth and false flag terror to the Big Brother police state, eugenics, geopolitics, the central banking fraud and more. The Corbett Report is edited, webmastered, written, produced and hosted by James Corbett. James Corbett has been living and working in Japan since 2004. He started The Corbett Report website in 2007 as an outlet for independent critical analysis of politics, society, history, and economics. Since then he has written, recorded and edited thousands of hours of audio and video media for the website, including a podcast and several regular online video series. He is the lead editorial writer for The International Forecaster, the e-newsletter created by the late Bob Chapman. His work has been carried online by a wide variety of websites and his videos have garnered over 50,000,000 views on YouTube alone. His satirical piece on the discrepancies in the official account of September 11th, “9/11: A Conspiracy Theory” was posted to the web on September 11, 2011 and has so far been viewed nearly 3 million times. For more information about Corbett and his background, please listen to Episode 163 of The Corbett Report podcast, Meet James Corbett: Episode 163 – Meet James Corbett Broc West has been the Video Editor of The Corbett Report since December 2014. He currently lives in Southern Vietnam. Twitter: @brocwest Audio taken from: https://www.corbettreport.com/interview-1551-jonathan-latham-on-gene-drives-and-the-gates-foundation/

In this episode, Jeffrey discusses the new patents being considered for Gene Drives.  One of the recent Gene Drives involved GM Mosquitos being released in Brazil to combat the spread of malaria.  Oxitec, the developers of the GM mosquitos have consistently lied to the public about the science and about the dangerous permanent effects the mosquitos will have on existing populations.  You can learn more about GM mosquitos here: https://stopgmm.com/ The Institute for Responsible Technology is working to protect you & the World from GMOs (and while we're at it, Roundup®...)  To find out exactly how we do this and to subscribe to our newsletter visit https://www.responsibletechnology.org/ Join us at Protect Nature Now to Safeguarding Biological Evolution from GMOs 2.0. The place to get critical up to date information, watch our short film and most importantly, learn easy ways for you to take action against this existential threat. Visit: https://protectnaturenow.com/ Watch "Don't Let the Gene Out of the Bottle" Get the book: "Seeds of Deception" Sign the Petition https://protectnaturenow.com/signthepetition/ IG @irtnogmos Facebook @responsibletechnology YouTube @TheInstituteforResponsibleTechinology Twitter @TheInstituteforResponsibleTechnology  

Gene-Drive, Bevölkerungskontrolle, Klaus Schwab und Bill GatesEin Standpunkt von Markus Fiedler.Denken Sie an den neuesten James Bond Film „Keine Zeit zu sterben“, verlegen das Szenario in ein beliebiges ukrainisches Biolabor, paaren das ganze mit jemandem, der dem glatzköpfigen und katzenkraulenden Oberschurken aus dem James Bond Film „Man lebt nur zweimal“ recht ähnlich sieht. Und voila! Sie bekommen einen Gruselschocker, der Ihnen Albträume bescheren wird.Das heutige Thema umfasst die angebliche Überbevölkerung und vor allem was selbsternannte Heilsbringer mittels Bevölkerungskontrolle dagegen tun wollen.Es gibt 7,5 Milliarden, bald 8 Milliarden Menschen auf dem Planeten. Viele Science-Fiction-Romane beschäftigen sich mit dem Thema Überbevölkerung. Einer von diesen dystopischen Romanen ist „Soilent Green“ oder „Jahr 2022, die überleben wollen“ in deutscher Sprache, veröffentlicht als Film im Jahr 1979. ... hier weiterlesen: https://apolut.net/biowaffenlabore-in-der-ukraine-von-markus-fiedler+++Apolut ist auch als kostenlose App für Android- und iOS-Geräte verfügbar! Über unsere Homepage kommen Sie zu den Stores von Apple und Huawei. Hier der Link: https://apolut.net/app/Die apolut-App steht auch zum Download (als sogenannte Standalone- oder APK-App) auf unserer Homepage zur Verfügung. Mit diesem Link können Sie die App auf Ihr Smartphone herunterladen: https://apolut.net/apolut_app.apk+++Abonnieren Sie jetzt den apolut-Newsletter: https://apolut.net/newsletter/+++Ihnen gefällt unser Programm? Informationen zu Unterstützungsmöglichkeiten finden Sie hier: https://apolut.net/unterstuetzen/+++Unterstützung für apolut kann auch als Kleidung getragen werden! Hier der Link zu unserem Fan-Shop: https://harlekinshop.com/pages/apolut+++Website und Social Media:Website: https://apolut.net/Odysee: https://odysee.com/@apolut:aRumble: https://rumble.com/ApolutInstagram: https://www.instagram.com/apolut_net/Gettr: https://gettr.com/user/apolut_netTwitter: https://twitter.com/apolut_netTelegram: https://t.me/s/apolutFacebook: https://www.facebook.com/apolut/Soundcloud: https://soundcloud.com/apolut See acast.com/privacy for privacy and opt-out information.

Abdoulaye Diabate is leading the research on genetic technologies for malaria control in Burkina Faso, the only country in Africa to be working with genetically modified mosquitoes. He hopes to bring gene drive, an innovative genetic tool which could help reduce malaria transmission, to Africa in the future.

Jeff, Virgil and Mark discuss the passing of former Mahoning Drive-In projectionist Gene DeSantis (who ran the projectors from the 1940s to the 2000s) and share their own Drive-In memories and rituals. Recorded 1/5/22 For exclusive additional podcasts, videos, sneak peeks, and on-site discounts, visit the Mahoning Drive-In Patreon page at: https://www.patreon.com/mahoningdrivein https://www.mahoningdit.com/ https://www.facebook.com/mahoningdriveintheater/ https://www.instagram.com/mahoningdriveintheater/ https://twitter.com/mahoningdit --- Send in a voice message: https://anchor.fm/mahoningdrivein/message

Clones, mutations, genetic modifications, and diseases eliminations… while those may sound magically fantastical, the secrets of all those topics and more are revealed in Olivia Pembridge's undergraduate runner-up audio “Gene Drives.”   Olivia will captivate you as she paints interconnected visuals that ease the listener into complex scientific topics and uses supplementary audio to drive home her main points. She debunks ethical concerns by interviewing experts in the field, namely Kathy Freedman, a Vanderbilt University geneticist, Thomas Clemens, a Vanderbilt University crisper researcher, and Leah Buckman, a Texas A&M entomology PhD Candidate who answers the question, “How bad is the bad?” 

Genetic Engineering and Society Center GES Colloquium - Tuesdays 12-1PM (via Zoom) NC State University | http://go.ncsu.edu/ges-colloquium | GES Mediasite - See videos, full abstracts, speaker bios, and slides https://go.ncsu.edu/ges-mediasite | Twitter - https://twitter.com/GESCenterNCSU STS Roles in developing technologies of humility around gene drives Dr. Sam Weiss Evans, Senior Research Fellow at the Program on Science, Technology & Society, Harvard University Website | Twitter As different groups work out whether and how to pursue gene drive organisms, Sam Weiss Evans explores the ways STS researchers can enrich the attention to diverse perspectives, equity, vulnerability, and learning. Abstract In the development of gene drives, claimsr ecosystem-altering capabilities are often coupled with calls for research programs to engage with diverse groups. This talk explores the ways that STS researchers have helped shape the development of gene drives, drawing out the various roles they have had and how those roles have and have not advanced a research and policy agenda that favors attention to technologies of humility: contrasting framings, the distribution of benefits and harms, the capabilities of vulnerable populations to be heard and responded to, and the potential for institutionalized learning over time. Speaker Bio Dr. Sam Weiss Evans is a Lecturer and Research Associate at Harvard's John A. Paulson School of Engineering and Applied Sciences, a Research Fellow in Harvard's Program on Science, Technology, and Society at the John F. Kennedy School of Government, a Research Affiliate in the Program on Emerging Technology at the Center for International Studies at MIT, and a Research Affiliate at the University of Cambridge's Centre for the Study of Existential Risk. Sam is worried that security is thought about too much by people who just think about security, and not enough by people who don't. How are decisions made about what areas of science and technology become objects of security concerns? How are decisions about whether something is a threat tied to our ways of managing, or ignoring, that [non-]threat? These are some of the questions Sam likes to ask. Other questions focus on the relationship between people like him—Science and Technology Studies researchers—and the people whom he works with and studies. What is the appropriate amount of critical distance to be able to see the context of an environment clearly while still being close enough to the action to have some influence on it? Sam loves trying out different answers to these questions and learning from them. He also loves learning from you. GES Center - Integrating scientific knowledge & diverse public values in shaping the futures of biotechnology. Find out more at https://ges-center-lectures-ncsu.pinecast.co

Andy Dybala shares his latest research into how the mRNA vaccine wouldn't be possible without the use of synthetic nanoparticle technology. He also showcases his work into "Gene Drives" and how the scientists can manipulate genes using CRISPR and Synthetic NanoParticle Technology. Patreon: https://www.patreon.com/andydybala Twitter: https://twitter.com/LivewithAndy NeighborhoodNewsStudio.com/

Genetic Engineering and Society Center GES Colloquium - Tuesdays 12-1PM (via Zoom) NC State University | http://go.ncsu.edu/ges-colloquium GES Mediasite - See videos, full abstracts, speaker bios, and slides https://go.ncsu.edu/ges-mediasite Twitter - https://twitter.com/GESCenterNCSU The missing ecology in gene drive research Dr. Sumit Dhole, Research Scholar in Mathematical Biology, NC State LinkedIn | Google Scholar A discussion about some of the ecological aspects of population suppression using gene drives, and areas that need more research. Abstract Gene drives are rapidly emerging as a potential tool for controlling populations of disease vectors, invasive species and agricultural pests. The molecular research to create new and improved gene drives based on the CRISPR technology has progressed rapidly. While this research has been encouraging from the perspective of developing these tools, there remain large gaps in our understanding of how natural populations would respond to the release of gene drives. Dr. Dhole will discuss some of the ecological processes that will play an important role and that need more research in natural pest populations. Related links: Rajagopalan PK, Curtis CF, Brooks GD, Menon PK. The density dependence of larval mortality of Culex pipiens fatigans in an urban situation and prediction of its effects on genetic control operations. Indian J Med Res. 1977. North, A., Burt, A. & Godfray, H. Modelling the potential of genetic control of malaria mosquitoes at national scale. BMC Biol 17, 26 (2019). https://doi.org/10.1186/s12915-019-0645-5 James J Bull, Christopher H Remien, Stephen M Krone, Gene-drive-mediated extinction is thwarted by population structure and evolution of sib mating. Evolution, Medicine, and Public Health, Volume 2019, Issue 1, 2019, Pages 66–81, https://doi.org/10.1093/emph/eoz014 Speaker Bio Dr. Sumit Dhole is an evolutionary ecologist who uses mathematical models to study how genes can spread through natural populations. For the past few years at NC State his focus has been on understanding how synthetic gene drives might behave if introduced into natural populations. While gene drives, which are highly invasive genetic constructs, may provide a solution for rapid and species-specific management of disease vectors and agricultural pests, a major concern is the potential of their unchecked spread to non-target populations. Through his work, Sumit tries to understand what factors and design features may allow synthetic gene drives to spread in safe, contained manners. GES Center - Integrating scientific knowledge & diverse public values in shaping the futures of biotechnology. Find out more at https://ges-center-lectures-ncsu.pinecast.co

In this episode, Shobita and Jack compare how the US and UK governments are managing risk and uncertainty in both pandemic policymaking and in their evolving artificial intelligence strategies. And they chat with Jason Delborne, a professor at North Carolina State University who has done both research and public and policy engagement related to gene drives, a new form of biotechnology that could transform our ecosystems.National Academies of Science, Engineering, and Medicine (2019). Forest Health and Biotechnology: Possibilities and Considerations. National Academies Press.National Academies of Science, Engineering, and Medicine (2016). Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. National Academies Press.America in One Room (2020). Executive Summary.Delborne, J. A. (2019, January 18). Can genetic engineering save disappearing forests? The Conversation. http://theconversation.com/can-genetic-engineering-save-disappearing-forests-109793Delborne, J. A., Binder, A. R., Rivers, L., Barnes, J. C., Barnhill-Dilling, K., George, D., Kokotovich, A., & Sudweeks, J. (2018). Biotechnology, the American Chestnut Tree, and Public Engagement (Workshop Report). Genetic Engineering and Society Center. http://go.ncsu.edu/ges-chestnut-report.Long, K. C., Alphey, L., Annas, G. J., Bloss, C. S., Campbell, K. J., Champer, J., Chen, C.-H., Choudhary, A., Church, G. M., Collins, J. P., Cooper, K. L., Delborne, J. A., Edwards, O. R., Emerson, C. I., Esvelt, K., Evans, S. W., Friedman, R. M., Gantz, V. M., Gould, F., … Akbari, O. S. (2020). Core commitments for field trials of gene drive organisms. Science, 370(6523), 1417–1419. https://doi.org/10.1126/science.abd1908

Genetic Engineering and Society Center GES Colloquium - Tuesdays 12-1PM (via Zoom) NC State University | http://go.ncsu.edu/ges-colloquium GES Mediasite - See videos, full abstracts, speaker bios, and slides https://go.ncsu.edu/ges-mediasite Twitter - https://twitter.com/GESCenterNCSU Stakeholder engagement in gene drive research: A Target Malaria case study Dr. Léa Paré, Stakeholder Engagement Lead at Target Malaria – Burkina Faso Website | Twitter @TargetMalaria Target Malaria's approach to stakeholder engagement is an iterative process, constantly adapting and evolving based on the context and values of our stakeholders, as well as new guidance and recommendations developed in accordance with international best practice. Abstract Stakeholder engagement is one of the three pillars of Target Malaria's approach. Our strategy is to focus on the communities that might benefit from the technology and that are directly affected by the research activities but also to have an ongoing, transparent dialogue with other stakeholders. The project uses ethically designed engagement best practices to empower these communities to make the most informed decisions about the project's work and its activities. Our stakeholder engagement approach is an iterative process, constantly adapting and evolving based on the context and values of our stakeholders, as well as new guidance and recommendations developed in accordance with international best practice. Related links: https://targetmalaria.org/ Speaker Bio Dr. Léa Paré obtained her doctorate in anthropology / sociology at the University of Aix Marseille 2 in France. She is Target Malaria's Stakeholder Engagement Lead in Burkina Faso. Throughout her training and career, Dr. Paré has developed a great interest in the field of research on malaria from an anthropological point of view. Dr. Paré's doctoral research enabled her to specialize in the socio-anthropological analysis of health problems in Africa. Author of several publications since 2000, she is interested in questions of social representations of malaria in connection with the acceptance of the means of control developed by science and technology. Her various works have underlined the need to think ahead for fundamental research in malaria control and to look at the perceptions, expectations and constraints of populations in relation to the use and allocation of research results by the beneficiary populations. Dr. Paré is one of the forerunners of the social sciences who are interested in the problems of genetically modified organisms from the point of view of local communities and stakeholders. GES Center - Integrating scientific knowledge & diverse public values in shaping the futures of biotechnology. Find out more at https://ges-center-lectures-ncsu.pinecast.co

Jianghong Min is a graduate student with the Department of Genetics at Harvard Medical School who is currently involved in genomics studies of the heritability of CRISPR-based gene drive cassettes to control specific functionalities in non-human species and their impact on genetic diseases. He is working on these projects at MIT with the Sculpting Evolution Group and Kevin Esvelt, Assistant Professor. Listen to the podcast to discover: Why trial work with CRISPR-based gene drive systems is important. What unintended consequences might result from genome editing techniques. What measures are being taken in the new CRISPR method to ensure safety in this area of science. What potential benefits are associated with manipulating heritable genes in non-human species such as mosquitos and mice. Min is working on a study involving the genetic editing of heritable genes using gene drive cassettes in a non-human genus. The study is in the exploration phase at this time. Of particular interest is the evolution of a gene drive system once it is released into the wild. How much genetic information can be included in the gene drive cassettes? How much control of the heritability of the gene drives do scientists have once the are released into the wild? Min is especially interested in discovering unintended consequences. Could these heritable changes spread into other nearby species? He believes in the precautionary principle that scientists should not intervene until all of the negative effects are known and should identify the greater impact of genetically modifying these organisms. To learn more, visit: MIT Media Lab: https://www.media.mit.edu Sculpting Evolution Group: www.sculptingevolution.org Episode also available on Apple Podcasts: apple.co/30PvU9C

Darum macht die Corona-Impfung nicht unfruchtbar; Tiemanns Wortgeflecht: Brezel; WiG: Wie mit Farben Werbung gemacht wird; Kein Risiko - Sport mit Maske; Rettung für das Eichhörnchen; Psychisch gut durch den Lockdown; Was leisten Roboter im All?; Fitness bei YouTube - was hilft gegen Rückenschmerzen?; Moderation: Marija Bakker.

This episode goes through 'Gene Drives'. This is biotechnology designed to ensure favourable traits pass through a population.  Article is taken from: https://www.sciencedaily.com/releases/2021/03/210306113147.htm

Mosquitoes carry diseases that kill more than 700,000 people every year... but do they deserve a death sentence? On this episode, we discuss a controversial technology called a "gene drive" that could allow us to wipe out disease-carrying mosquitoes. Should we use it? And what could go wrong? Highlights: what male mosquitoes eat, Invasion of the Body Snatchers, flesh-eating maggots, Nazis dropping mosquitoes out of airplanes

Catch the latest news on GMOs and Roundup. Then share this link to start the dominoes to the solutions.   To watch the trailer, "Don't Let the Gene out of the Bottle"  and to support Protect Nature Now visit: https://protectnaturenow.com/ The Institute for Responsible Technology is working to protect you & the World from GMOs (and while we’re at it, Roundup®...)  To find out exactly how we do this and to subscribe to our newsletter visit https://www.responsibletechnology.org/  

Mit Gentechnik gegen Malaria Insektenbekämpfung mittels Genome Editing und Gene Drive Im Jahr 2018 erkrankten weltweit über 200 Millionen Menschen an Malaria und mehr als 400.000 Erkrankte starben an den Folgen der Krankheit. Über zwei Drittel der Malaria-Toten waren Kinder unter fünf Jahren – die am meisten durch Malaria gefährdete Gruppe. Die lebensbedrohliche Malaria wird durch Parasiten verursacht, die von infizierten, weiblichen Anopheles-Mücken auf den Menschen übertragen werden. Obwohl es einige wirksame Insektizide gegen die Stechmücken gibt, entwickeln diese zunehmend Resistenzen. Neue gentechnische Verfahren zielen deshalb darauf ab, den Überträger, also die Anopheles-Mücke, genetisch zu verändern, um Malaria einzudämmen. Schon in den 1930er Jahren wurde über genveränderte Insekten als Alternative zu Insektiziden nachgedacht. Seitdem wurden mehr oder weniger erfolgreich einige krankheitsübertragene Stechmücken oder anderweitige Schadinsekten unter Kontrolle gebracht. Neue gentechnische Verfahren wie Genome Editing und Gene Drive könnten solche Verfahren verfeinern und eventuell sogar dazu genutzt werden, Krankheiten wie Malaria für immer zu beseitigen.

Anna Clark is a geneticist investigating candidate genes for mammalian Gene Drive pest control.

Mit der Genschere Crispr-Cas9 und dem Gene Drive ist es möglich, Gene auch über Generationen zu verändern. Welche Chancen und Risiken birgt das? >> Artikel zum Nachlesen: https://detektor.fm/wissen/forschungsquartett-crisprcas9-gene-drive

Anthony James describes how gene drives can be used to spread malaria parasite resistance in mosquitoes.

Kevin Esvelt (MIT Media Lab) discusses his interest in gene drives and other gene editing approaches to combat tick-borne diseases and malaria.

What's the Word: Homeostasis; News Items: Universe Resolution, Scientific Consensus, Hobbit Update, Gene Drive in Mosquitoes, A Century of General Relativity; Your Questions and E-mails: Political Questions; Science or Fiction

It's one thing to genetically modify an organism in the lab. It's another thing entirely to spread those modifications in the wild, altering whole populations or even species. A new technology, the “CRISPR gene drive,” promises to do just that, giving human beings an unprecedented ability to fine-tune the natural world and nudge evolution in new directions. Malaria-resistant mosquitoes? Lyme-blocking ticks? Those are just a few of the applications floated so far, but the possibilities are endless. I talked to molecular biologist and “evolutionary sculptor” Kevin Esvelt, who first proposed the CRISPR gene drive, about its potential, perils and steps to ensure that we use our new powers wisely. Topics covered include: The CRISPR revolution: fast, cheap gene editing Gene drives: CRISPR on auto-pilot Using gene drives to fight disease and suppress pests Safeguards, controls and oversight More evo-sculpting: Kevin's PACE system, harnessing viral evolution to create novel biomolecules Personally, I find the implications of gene drives to be fairly head-spinning. Imagine self-propagating genes that spread inexorably even when they offer no selective advantage – even when they're maladaptive! Of course, like a too-virulent pathogen, really maladaptive CRISPR drives might put themselves out of business by killing off their hosts, and selective pressures would favor mutations that incapacitate the drive, but still…