POPULARITY
74 episodes with mdms
2 episodes with mdms
2 episodes with mdms
Joining Jack & Eden is Katrina Retallick and Lisa Callingham who are playing Housewife and Soap Star in Menopause the Musical at the Athenaeum Theatre. They also touch on CLOC's non-professional premiere of Come From Away, MDMS's Sweet Charity production and share some BREAKING theatre news. THE LINKS Our website Our Instagram Our TikTok Katrina's Instagram Lisa's Instagram Book Menopause the Musical tickets!
Jay Leedy probably had a bunch of options open to him when he decided he'd done his job with Sony's pro display team, and it might have surprised some of his industry friends when he signed on with a much smaller company, New York-based Videri, as its Senior VP for Strategic Alliances. It didn't surprise me, because Videri has been on a bit of a tear in the last few months, hiring well-connected and respected senior people away from other companies active in digital signage. That came out of a $20 million fundraising round announced late last year. I did a podcast about a year ago with Videri CEO Wes Nicol, so I didn't want to spend too much time talking again about Videri's product and services. We get into that and what attracted Leedy, but what I was really interested in hearing about was his point of view on the CMS software market. His prior role with Sony was building up the digital signage software ecosystem, which involved talking to and looking at scores of different companies. He eventually onboarded some 90 in his three-plus years there, about 70 of them CMS software firms. So Leedy has a pretty unique perspective on what's out there, and how companies differentiate themselves in what remains a very crowded CMS software market. Subscribe from wherever you pick up new podcasts. TRANSCRIPT Jay Leedy, thank you for joining me. You've had some big changes in the last few weeks. Jay Leedy: Thank you. I have. Thanks for having me, Dave. It's great to hear your voice. Yeah, you don't want to see me. Jay Leedy: It's been a couple of months since I saw you last at ISE, but yeah, some changes that were on the horizon at ISE kind of came to fruition over the last several months, and I'm happy to say I'm in my fourth week, almost complete with my fourth week here at Videri. Wow, you're almost past probation. Are you going to make it? Jay Leedy: They haven't kicked me out yet. My wife told me that the paycheck showed up in our bank account yesterday. Yay! Things are rocking. I knew you when you were with Convergent and Diversified then you went over to Sony. Am I missing anything there? Jay Leedy: I think that's the extent of my career in this space. I got introduced to integrations prior to moving to Convergent through a company that had point-of-purchase display manufacturing as their core and had a division that focused on, what we called Intelligent Loss Prevention. We were basically importing a lot of technology solutions to solve theft prevention in retail and that's how I got exposed to systems integration, and when I saw digital signage as a part of that, I naturally gravitated toward that. I saw there was going to be a big growth arc and fortunately, I've been right so far. We can get into what you were doing with Sony because I'm intrigued by the role you had and the unique perspective that was offered, but I'm curious because when you started thinking, okay, I've done my job here with Sony and what's my next thing? What compelled you to go to Videri, I suspect you had a number of options. Jay Leedy: Yeah, it's a good question. The little background that I just gave you is in part why Videri was really appealing to me. You're right. I had really broad exposure to the market across a number of technologies, not just digital signage, and was considering options outside of digital signage, to be perfectly honest, but the reason that Videri was compelling for me was a couple of reasons. One is the, very strong push they were making into the market with some clear funding and a product offering that was differentiated in displays that were very thin and lightweight looking and appealed to the sensibilities of retailers and designers and the folks that I really like engaging with on the creative side of our business, combined with software that really makes it easy to make these things pop and, deliver what we call orchestration of content across multiple canvases of displays to unify those. But there were some other things that went into that as well. I met Rob Avery, who had recently joined the company from Scala, at your event at ISE. I'd already met Wes Nicol, the CEO, about a year prior, and then Steven Jenkins, who I'd worked with at Diversified, had recently joined as the CRO along with Nathan Jones, who I'd also worked with as a Managing Director for North America. So there are already some pieces in place, and when I met Rob and we chatted briefly about his point of view on where we are versus where he wanted to take the software on the roadmap, that really clicked with me. Then we announced Jeff Griffin coming in as a retail technology guru and a guy who was at the genesis of what we called Walmart TV. So it wasn't even digital signage when he was involved with that deployment. So he's had a long history of selling into that market, and really the last piece to fall into place for me was, we secured, Tom Ross from NowSignage and I think he must eat energy bars constantly. He has the most energy and passion for the channel of any guy that I've met in this industry, and I've met a lot. All of those things coming together was really a big part of making that decision for me. Yeah, it's interesting. I've told the story a few times of couple of years ago at DSC in Vegas, some company called Videri had reached out to me and said, could you come to our suite at ARIA and have a look at our pots and pans? And I said, I'm super busy, and so on, and they bugged me and on the last day in the afternoon, I was dead tired, but I said, okay, fine, because I was staying next door and I didn't know a damn thing about them and met them, walked this endless hallway to get to their suite and they showed me these flat panel displays. I thought, oh, dear God, I've walked all this way to see some skinny displays, but then they started to explain what they're up to, the business model and how they were working with a very large Austrian energy drink brand that they're not allowed to officially talk about, and I thought, now I get it, and over those, intervening two years, the company has really grown in terms of marketplace visibility and everything else and they have a somewhat unique, not entirely unique, but somewhat unique product. Jay Leedy: Yeah, I agree. In fact, I was registered to go to that same event but couldn't get there because I was super busy that week. I also didn't have a relationship with them yet. So I didn't yet feel obligated, but I didn't see their product until Digital Signage Week, or maybe it was NRF, one of the two where they had a hospitality event at their offices in New York and I made my way there and I was as compelled as you were because of what they were doing but also where they were saying they were going. And you're right. The visibility for Videri has been exponential. I think as contemporaries in our sphere of the industry have gotten more visibility to their hardware and a better understanding of whether software can cause the entire industry to really lean in and that's been the case. I think when I announced that I was leaving Sony combined with two days later announcing that I was joining Videri, I never had as much web traffic on my LinkedIn as those two days. I think it was something on the order of 15,000 impressions between the two posts and that tells me that there's a lot of people who were really intrigued about what this new company is and as I've gotten deeper into the organization and started to really look around at the core architecture of our software, which is an Android-based SoC. So all of our displays run Android 12, which offers a lot of opportunity for third-party solutions to run alongside ours, or in some cases, in place of our software with our firmware being the glue that binds the delivery of that software, and I think there's a lot of opportunities in that regard as well, right? My goal will really be to build out an ecosystem and a partner strategy very similar to what I was doing at Sony and fortunately, I have a lot of existing relationships that I was already working with that can parlay right into that, that are all dialed into that Android approach, but I think Android, in particular, was compelling for me because it has become a de facto standard in many respects and in a lot of cases with retailers, because of the security components to it, and our particular flavor of Android is locked down, which is really appealing. all the stars really aligned there. It's interesting because Android, if you asked people out five years ago, they would probably say no, not going anywhere near that. Jay Leedy: I know when I was Diversified, it was an absolute non-starter, but the market's changed, and fortunately the strength of Android and the security protocols have changed, and I think it's you and I've talked about a little bit, right? The impression and kind of point of view on Android Deployed in enterprise environments has changed as well. I think largely because of the broad use of MDMs or device management solutions and familiarity with those tools, with IT admins having a level of comfort with those. At the end of the day, displays for digital signage are IOT devices that have to be managed and locked down in a similar fashion. So something that's familiar just resonates with those decision makers. You mentioned a couple of minutes ago third party suppliers or providers. Are you saying, and you can correct me if I'm getting this wrong, that if I'm another CMS software company, I could, in theory, drive Videri displays? Jay Leedy: Absolutely, and we've already tested a handful of them. I think we've got about five so far. We've also tested some lift-and-learn solutions that are quasi-CMS but would also be able to run in concert with our CMS. That'd be like Glass Media stuff? Jay Leedy: It's more like Sign Metrics. We're on ARC over at Pick‘n'Watch. He's got a really interesting solution that's all Bluetooth and UDP-based. We're also looking at wireless solutions for audience measurement, the likes of Blue Zoo or Movia Media. Some of the CMS platforms that we've tested, run the gamut of the kind of those that are known more heavily in the space, like Spp Space and Corbett, and then others that are maybe lesser known like Play Signage or one of the newer ones that, as you mentioned earlier, the idea of a hobby business that's not yet full bore or fully funded or has a sales and marketing team behind it, what have you… There's a company called AbleSign that's got some pretty capable products. Largely a lot of these are available as progressive web app options where the device management capabilities of their full-featured apps are stripped out and therefore don't present a conflict with some of the remote capabilities that are the device management capabilities that we bring to bear. But, in the longer term, we'll also test scenarios where maybe a full-featured solution could be used or what we see more as a trend; why I was looking maybe outside of digital signage, in other technology providers, is that, especially in North America, and I think that this will cascade to other markets is that enterprise clients, in particular, have a point of view on device management. So, it was really important when I was at Sony to be compatible with whatever infrastructure decisions had been made upstream so that we could just say yes to projects and be specified regardless of what the requirements were. To some extent, that's a consideration with Videri's approach as well. It's interesting, with this idea that you can work with other CMS software companies. I'm trying to envision that phone call or that meeting on their end, wouldn't they be saying that you have a software that competes with our software? Jay Leedy: Yeah, but I think we also have a really attractive line of hardware, right? The kind of customer that will gravitate towards our hardware may, in some cases, already have an investment and an existing state of software that they don't want to deviate from. So it may make sense for us to offer our hardware with some recurring fees for the support and device management components while also being able to enable content management on a familiar platform that is more broadly used across their estate. Those are scenarios that we're gaming out. What drew my attention in the tippet area is how the square displays in particular were something that could replace old beverage brands' neon or plastic backlit signs in bars and restaurants. It was something that was dynamic, the quick ROI that would come out of that, but I've seen Videri in particular marketing, multi-screen video cone matrix. I think there's another word you guys use. Jay Leedy: We call it an orchestration, but yeah, it'd be a mosaic or a configuration of multi-canvas screens that, in some cases, we're seeing incorporated with other visual merchandising elements or other artwork elements in hospitality applications, for example. You might like static, traditional artwork and imagery interspersed with dynamic elements that are part of Videri. The entire wall can very easily be mapped, and content pushed and split across the displays so that it makes sense visually without a lot of hardware to deliver that, and I think that's really a unique element of our software. Yeah, and I like the ability to mix and match squares and rectangles display canvases and I know Samsung had a square product years ago, and it came and went because they like to sell hundreds of thousands, not thousands of units, but it came back with this and because manufacturers in Asia are now able to natively manufacture square things instead of cutting a rectangle and turning it into a square, redoing the electronics and costing a lot of money. Jay Leedy: Yeah, the run rate on our square product versus the other ones is probably not as high, to be fair, but those unique shapes and, I think, more specifically, smaller form factors, the lighter weight, the bezels are only probably about three quarters of an inch thick. The fact that they're low-voltage offers a lot of flexibility. We've got a shop fitter or a point-of-purchase display manufacturer in Germany that's developed a unique bracket that allows these displays to be moved around in their modular system. The entire system is powered with low voltage. It's a company called Visplay, and they've done some really interesting stuff. These powered, essentially track systems or grids have ports, and the brackets are designed to automatically pick up power as soon as they do. Once they hit the Wi-Fi, they just start playing content again. So it gives the retailer or the shop fitter a lot of modularity, and they don't have to get a technician on-site to make these changes. It's something that they can do with store staff and that's really appealing as well. That's interesting. I've been doing a lot of reading and paying a lot of attention to the whole retail media networks landscape of late because it's obviously got a lot of traction, even though much of the spending now is not in the store but billboards and online, but it's going that way and I've said and heard from people that it's not going to be a second wave of stores, putting big ass LCD displays on every available surface like it maybe was in the 2010s when athletic wear retailers, in particular, were doing that. It's going to have to be smaller displays and interesting displays that fit into the design and are designed from the start or ones that don't get in the way of merchandising. Jay Leedy: Yeah, exactly. I think we've seen that in various gestations over the last several years, especially in consumer packaged goods, brands will incorporate digital elements as part of a turnkey fixture package. It's one of the things I was working on with Diversified prior to the pandemic, and unfortunately, the pandemic killed the momentum on a project that was really promising for us. But it was in partnership with Westrock, and the idea was that, as Diversified, we would be the integrator and managed service provider to support design, build, and ultimately manage and service these things once deployed. Westrock designed the fixture and also what they called kit packing. So they brought in inventory from their partner at the time, GlaxoSmithKline. They fully merchandised a display fitted with graphics and then added our digital elements with an LTE modem cradle point. As soon as the store personnel received it, which they wielded into place, they didn't have to have a technician. Essentially, they had a turnkey solution that, as soon as it was plugged in, called home and had a range of content that would be played based on a number of parameters. There was an integrated camera. So, I think there's a really appealing turnkey solution that doesn't have to rely on the retailer's data infrastructure, which is usually fairly constrained. This gives the brands a lot more freedom for placement but a lot more control over execution as well as the ability to, as you rightly said, put digital in places where you wouldn't expect it, and that's a hallmark of our approach, right? These smaller screens are unique form factors that are less obtrusive and don't detract from the merchandising but actually can complement it, and you're right, I think retail media networks will manifest in that way so that it's not an afterthought. It's not a screen that's hanging from the ceilings left in front of the end cap, but it's actually integrated into the end cap or into the merchandising fixture or what have you. So it really does the job of carrying the brand message, and I think there's a lot of appeal there, especially in lifestyle brands. Especially for a product where, through our orchestration, we could draw attention to an entire category or shop within a store rather than just having individual merchandising fixtures, each with its own message. The adoption barrier that I've encountered when I've talked to brands about this, what you were just describing is they like it, but they only need it for six weeks or four weeks or some defined campaign term, and even though they may be a big CPG brand with all kinds of products they're so siloed that you couldn't just say, “This shampoo digital fixture could be a body lotion fixture for round two, and you could share it across different ones.” They'd say, “Yeah, but that would never happen.” Jay Leedy: Yeah, that was actually the concept of the one that we were working on with Westrock and GlaxoSmithKline. So the idea was that it'd be a seasonal product that was focused on at the time, Flonase and Claritin, and then once the season for allergies was over, they would pivot to another product that was better suited to the next season. That was exactly the concept. I think you're right. There is a seasonality to these activities, but the beauty of digital is that you can effectively reskin these things and repurpose them. So long as you have an intelligent design and the rest of the fixture to accommodate a range of products, and basically send in another kit of graphics and merchandise to correspond with that in partnership with a kit packer like Westrock. You can clarify your role with Sony, which you were there for two or three years, I think. But what I found intriguing now that you're not there is that your gig was basically developing partnerships for Sony to use its smart displays. When you started, there were, I think, one or two, maybe, and by the time you left, I think you were past 80 different partners. So you had this unique perspective of talking to a whole bunch of CMS software companies about what they had and analyzing whether there was a fit, and I'm just curious, having seen all these different ones and now somewhat detached from them, what your impression? Are they all the same, which is, I think what most people would think? Jay Leedy: Yeah, I was there for three and a half years, and you're right. When I came on, there was exactly one product that had gone through any kind of formal due diligence or QA, and so my program was really about building out that ecosystem with some formalities and processes, and I was fortunate enough to talk to and onboard roughly 90 different technologies that were, I'd say maybe 70% of those were digital signage and the rest were spread between unified communications or AV over IP as a software-defined solution. We also had a range of telemetry and UCC solutions as well. I think I had exposure to roughly 140 companies or so. On the CMS front, I know Invidus recently did a report that you commented on in your blog as well, and you're not wrong, for the most part, a lot of CMS platforms, at their core, do the same thing. The difference is how they do it. For me, the flexibility in their architecture, as I mentioned earlier, the idea of progressive web apps that decouple some of the real differentiation early in the market, that was an all-in-one solution with device management, has kind of evolved to the point where customers want flexibility and deciding and decoupling that device management from CMS but there's also, I think, the extent to which these companies have invested in APIs and manage those APIs and other data connectors and understand interoperability sets them apart. I think for me, with Videri and our clear focus on retail and creative agencies and optimizing and enabling workflows that would be API dependent, as well as a cloud-based SaaS that has the flexibility to be able to grow and evolve, in that direction, that was what was appealing for me. It's not to say that Videri was the only one with all those marks ticked in their offering, but as we talked about earlier, had some other organizational considerations that really were the determining factor for me coming over here. Without naming names or anything, did you see companies that were clearly more advanced versus ones that were maybe building on something that they've had for many years, and they're just incrementally bolting new capability onto an existing software stack? Jay Leedy: Yeah, absolutely. I think it's true for any company in the tech space that, at some point, you have to acknowledge that your technical debt load is too much and completely re-architect the solution. We've seen that happen with a number of companies in our space. There are a number of others that continue to struggle with that technical debt and architecture that just doesn't lend itself to meeting the expectations of the market. Were you recommending the key things that, whether you're a solutions partner or an end user, they should look for if they want to be future-proofed and really modern? Jay Leedy: First and foremost, these days, it's an API-first strategy. We need to ensure that There's a robust enough set of APIs to enable baseline telemetry and interoperability with a number of other API-first solutions. I think about, in particular, what's happening with digital transformation in large consultancies like Accenture, EY, and Deloitte. A lot of those hinge on moving from on-premise to cloud-based solutions for a range of business applications. If anybody listening to this podcast is using Office 365, for example, there are a number of third-party solutions that plug into those, obviously with a fee involved. However, to enable that, you have to have the right architecture, and digital signage isn't that different. We talk a little bit in this industry about headless and the idea of headless means, I think, escapes some people. I think the idea of no or low code development also, I think, escapes some people, but both of those are similar in that they enable. A much lower cost of entry to get a lot more functionality because the architecture is built in such a way that it can just essentially plug in like a Lego, and you can create building blocks that are predefined, versus having to have a linear development approach that can be really cost intensive. Yeah, I was on a call yesterday, and it was interesting. They were talking very much about that. From my perspective, if you have a solution that has a distinct login and you have to do everything digital signage through that login, with no real hooks into anything else, that's a big challenge, particularly for larger organizations that want to use one tool set. It's going to push out to whatever the endpoint is and whatever that endpoint is communicating. Jay Leedy: Yeah, and also just thinking about all the different ways content can be generated now. There's been a lot of buzz around generative AI, but the rules for content and distribution largely have been in most of these CMS platforms for a long time. But a means of automating those rules and creating if this, then that scenario or ingesting data that can then drive outcomes and content. that's not necessarily core to a lot of those platforms, or leveraging API calls directly from digital asset management tools and leveraging all of the metadata tagging logic that is built into those, and pulling those directly into the content strategy also necessarily isn't native to a lot of CMS platforms. So I think those are all kinds of key things to consider when making a selection or at least knowing, if it's possible downstream, should your company mature to the point where they want to leverage those types of tools. If people want to catch up with you and talk about what you're doing with Videri, I know they can find you online, obviously, but you'll be at Infocomm? Jay Leedy: I will be at Infocomm and the Digital Signage Federation mixer in Tampa in about two weeks. Either way, I'd love to see you and continue the conversation. All right, Jay. It's great to catch up. Jay Leedy: Great to see you as well, Dave.
Remember When - Philip Brady and Simon Owens ep 1001 - Sun 12 May, 2024 Remember When is broadcast live every Sunday evening from 9pm until midnight on 3AW in Melbourne - You can listen or watch live through www.3aw.com.au or on the old fashioned wireless. : P J Lane is our Remember When Legend : Rick Milne talks Antiques and Collectables : Kevin Trask takes us to 1956 in Trask's Time Tunnel : Music montage of the hits of 1961 : Lyn, Nicola and Mark from MDMS give us a sneak preview of their production of Phantom of the Opera : Tony McManus previews Australia Overnight : Produced by Zac Briffa with Eddie Summerfield in the newsbooth.See omnystudio.com/listener for privacy information.
Yural Maskey and Pratima Adhikari, the dynamic duo behind 'GadgetByte,' Nepal's leading tech review news portal joined us for a lively conversation. The tech geeks delve into the much-anticipated iPhone 15, discuss the latest trends in smartphones, and explore the implementation of the Mobile Device Management System (MDMS) in Nepal. They also dissect the ever-growing cult of influencer marketing in the tech world.
The MDMS theatre company are staging the Sound of Music at the Karralyka Theatre from May 26th. Richard Thomas and Nadia Gianinotti join Philip and Simon to chat about it and to perform live in studio See omnystudio.com/listener for privacy information.
A ~200 pc-sized core of Milky Way dark matter halo constrained from the OGLE micro-lensing sky map by Shu-Rui Lin et al. on Tuesday 22 November We report the detection of a 219 $^{+10}_{-28}$ pc-sized dark matter core structure in the center of Milky Way at $68%$ confidence level by using the micro-lensing event rate sky map data from the Optical Gravitational Lensing Experiment (OGLE) survey. For the first time, we apply the spacial information of the micro-lensing sky map and model it with the detailed Milky Way structure, the Mini Dark Matter Structure (MDMS) fraction ($f_{rm MDMS}=Omega_{rm MDMS}/Omega_{rm DM}$) and the core size. We find that this sky map can constrain both $f_{rm MDMS}$ and the core size simultaneously without strong degeneracy. This discovery provides not only guidance for dark matter particle models, such as self-interacting dark matter (SIDM), but also the baryonic physics of Milky Way. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.00666v2
A ~200 pc-sized core of Milky Way dark matter halo constrained from the OGLE micro-lensing sky map by Shu-Rui Lin et al. on Monday 21 November We report the detection of a 219 $^{+10}_{-28}$ pc-sized dark matter core structure in the center of Milky Way at $68%$ confidence level by using the micro-lensing event rate sky map data from the Optical Gravitational Lensing Experiment (OGLE) survey. For the first time, we apply the spacial information of the micro-lensing sky map and model it with the detailed Milky Way structure, the Mini Dark Matter Structure (MDMS) fraction ($f_{rm MDMS}=Omega_{rm MDMS}/Omega_{rm DM}$) and the core size. We find that this sky map can constrain both $f_{rm MDMS}$ and the core size simultaneously without strong degeneracy. This discovery provides not only guidance for dark matter particle models, such as self-interacting dark matter (SIDM), but also the baryonic physics of Milky Way. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.00666v2
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.10.515919v1?rss=1 Authors: Savulescu, A. F., Peton, N., Oosthuizen, D., Hazra, R., Mhlanga, M. M., Coussens, A. K. Abstract: Macrophages provide a first line of defense against invading pathogens, including the leading cause of bacterial mortality, Mycobacterium tuberculosis (Mtb). Phagocytosing extracellular organisms mediate pathogen clearance via a multitude of antimicrobial mechanisms, uniquely designed against an array of pathogens. Macrophages are able to execute different programs of activation in response to pathogenic challenge with host mediators, polarizing them to a variety of differentiation states, including the pro-inflammatory M1 and anti-inflammatory M2 states. The functional polarization of a macrophage prior to infection, thus impacts the outcome of host-pathogen interaction. One of the limitations when using in vitro differentiated human primary monocyte-derived macrophages (MDMs) is the heterogeneous nature of the mature population, which presents a challenge for quantitative characterization of various host-pathogen processes. Here, we describe an approach to minimize this heterogeneity, based on micropatterning of cells to reintroduce aspects of cellular homogeneity lost in a 2D tissue culture. Micropatterning consists of growing cells at the single cell level on microfabricated patterns, to constrain the size and shape of the cell, reducing cell-to-cell variation and mimicking the physiological spatial confinement that cells experience in tissues. We infected micropatterned GM-CSF- (M1) and M-CSF- (M2) derived human MDMs with Mtb, which allowed us to study host-pathogen interactions at a single cell level, at high resolution and in a quantitative manner, across tens to hundreds of cells in parallel. Using our approach, we were able to quantify phagocytosis of Mtb in MDMs, finding phagocytic contraction is increased by interferon-gamma stimulation, whilst contraction and bacterial uptake is decreased following silencing of phagocytosis regulator NHLRC2 or Tween80 removal of bacterial surface lipids. We also identify alterations in host organelle position within Mtb infected MDMs, as well as identifying differences in Mtb subcellular localization in relation to the microtubule organizing center (MTOC) and in line with the cellular polarity in M1 and M2 MDMs. Our approach described here can be adapted to study other host-pathogen interactions and co-infections in MDMs and can be coupled with downstream automated analytical approaches. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
VIDEOS: Dem Party Turns On Anti-War Democratic Primary Winner (2:16 to 5:28) Society is going to COLLAPSE -Neil Oliver ( 5:24) Fear Psychosis and the Cult of Safety – Why are People so Afraid? – Academy of Ideas (13:25) The Great Reset and Transhumanism | Beyond the Cover (17:50) Zinc supplementation associated with higher levels of brain growth factor Soybean foods may protect menopausal women against osteoporosis Study finds diet high in saturated fat can reprogram immune cells in mice Coenzyme Q10 consumption reverses cholesterol transport Study confirms that processed foods key to rising obesity Violence on TV: Effects from age 3 can stretch into the teen years Zinc supplementation associated with higher levels of brain growth factor Iran University of Medical Sciences, November 4 2022. A review and meta-analysis of randomized, controlled trials affirmed an association between supplementing with zinc and higher circulating levels of brain-derived neurotrophic factor (BDNF). Brain-derived neurotrophic factor plays a positive role in the survival of brain cells known as neurons. A reduction in BDNF expression occurs in Alzheimer and Parkinson diseases, multiple sclerosis and amyotrophic lateral sclerosis. Antidepressants and anthocyanin supplements have been shown to increase BDNF gene expression, and serum or plasma levels have been elevated by exercise and omega-3 fatty acid, resveratrol or zinc supplementation. For their review and meta-analysis, Fahimeh Agh of Iran University of Medical Sciences and colleagues identified four trials that evaluated the effects of zinc supplements on serum or plasma BDNF levels among 185. Zinc dosages ranged from 25–30 milligrams per day given for 84–90 days. Pooled results of the trials found significantly higher BDNF levels among participants who received zinc compared with participants in the control groups. The increase in BDNF was significant at 30 milligram doses (which were used in 3 trials) and at all trial durations. Among the 3 trials that analyzed serum zinc levels, participants who were given zinc supplements had significantly increased zinc levels in comparison with the control participants. “A large body of evidence indicated BDNF as an important predictive factor for following the beginning, progress and cure of brain disorders due to its main role in brain neurogenesis and neuroplasticity,” Agh and her associates wrote. “Increased circulating levels of BDNF as a result of zinc supplementation suggest that zinc supplementation may be a safe and effective strategy to counteract neurodegenerative diseases that are correlated with low BDNF levels,” they concluded. Soybean foods may protect menopausal women against osteoporosis University of Hull (UK), November 1, 2022 Eating a diet rich in both soy protein and isoflavones can protect menopausal women from bone weakening and osteoporosis, according to the results of a preliminary study presented today at the Society for Endocrinology annual conference in Edinburgh. Soybean foods contain chemicals known as isoflavones that are similar in structure to oestrogen and so could theoretically protect women against osteoporosis by mimicking the action of oestrogen. In this study, researchers from the University of Hull gave two hundred women in early menopause a daily supplement containing soy protein with 66mg of isoflavones or a supplement with soy protein alone for six months. The researchers investigated changes in the women's bone activity by measuring certain proteins (βCTX and P1NP) in their blood. They found that the women on the soy diet with isoflavones had significantly lower levels of βCTX than the women on soy alone, suggesting that their rate of bone loss was slowing down and lowering their risk of developing osteoporosis. Women taking soy protein with isoflavones were also found to have decreased risk of cardiovascular disease than those taking soy alone. “The 66 mg of isoflavone that we use in this study is equivalent to eating an oriental diet, which is rich in soy foods. In contrast, we only get around 2-16 mg of isoflavone with the average western diet.” “Supplementing our food with isoflavones could lead to a significant decrease in the number of women being diagnosed with osteoporosis.” Study finds diet high in saturated fat can reprogram immune cells in mice Portland State University, November 7, 2022 A new study by Portland State University researchers is the first to show that eating a diet exclusively high in saturated fats can reprogram the mouse immune system, making it better able to fight off infection but more susceptible to systemic inflammatory conditions, including sepsis. Brooke Napier, assistant professor of biology at PSU, led the study, which was published in eLife. The ketogenic or “keto” diet is a popular high-fat diet used for weight loss or to control epileptic seizures. This study shows that when mice eat a ketogenic diet that is high in saturated fats it can have a significant impact on their immune system. A previous study by Napier and colleagues found that mice fed a high-fat, high-sugar Western diet were more susceptible to sepsis and had a higher mortality rate than mice fed a standard diet. In the current study, the researchers found similar effects in mice fed a high-fat ketogenic diet, suggesting that dietary fat may play a role in sepsis. The researchers focused on one particular fat found in the blood of the mice fed a ketogenic diet: palmitic acid, which is commonly found in animal fats and dairy products. Remarkably, mice fed a normal diet who were injected with palmitic acid also became more susceptible to sepsis. “It was just exposure to this one saturated fat that made them more susceptible to sepsis mortality,” says Napier. “The idea that you could have a specific fat in your diet that would cause such a drastic outcome in disease is kind of incredible.” Napier and her team next probed just how exactly high levels of palmitic acid could initiate sepsis. Their first clue came when they noticed that mice fed the Western diet, mice fed the ketogenic diet, and mice treated with palmitic acid all had high levels of inflammatory cytokines, immunological hormones that can cause fever and systemic inflammation during sepsis. The presence of the inflammatory cytokines suggested that palmitic acid could be affecting the immune system by causing inflammation, but Napier soon discovered that the story was more complicated—and more interesting—than that. Napier and colleagues also found that another type of fat may be able to counteract the harmful effects of palmitic acid. Oleic acid, a polyunsaturated fat found in many plant-based oils including olive oil, can block the synthesis of ceramide, a fatty substance that can initiate a stress response in cells and may play a role in the hyperinflammatory response that causes sepsis. When the researchers fed mice a ketogenic diet for two weeks but also gave them oleic acid for the final three days, they no longer showed an increased susceptibility to sepsis. Coenzyme Q10 consumption reverses cholesterol transport Sun Yat Sen University (Taiwan), October 31, 2022 According to news reporting out of Guangdong, People's Republic of China, research stated, “We have recently shown that coenzyme Q10 (CoQ10) enhances macrophage reverse cholesterol transport via activator protein-1/miRNA-378/ABCG1 signal pathway in vivo and in vitro. Whether CoQ10 exerts similar beneficial effects in human is currently unknown.” Our news journalists obtained a quote from the research from Sun Yat Sen University, “The present study evaluated the effect of CoQ10 on ABCG1-mediated macrophage cholesterol efflux in 20 healthy volunteers. Participants were given 100 mg CoQ10 twice daily or placebo for 1 week with a 1-week washout period. Human monocyte-derived macrophages (MDMs) were differentiated under pooled sera obtained before (preCoQ10) or after CoQ10 (postCoQ10) consumption. The CoQ10-induced inhibition of MDMs foam cell formation was blocked by ABCG1 silencing in postCoQ10 MDMs incubated with postCoQ10 sera compared to preCoQ10 sera. The cholesterol efflux to HDL, and mRNA as well as protein expressions of ATP-binding cassette transporter G1 (ABCG1) were augmented in postCoQ10 MDMs incubated with postCoQ10 sera compared to preCoQ10 sera. The change in the serum CoQ10 concentration positively correlated with cholesterol efflux to HDL and ABCG1 mRNA level in the CoQ10 group. MDMs treated with purified CoQ10 had an enhanced cholesterol efflux to HDL.” According to the news editors, the research concluded: “CoQ10 consumption may have an atheroprotective property by inducing ABCG1 expression and enhancing HDL-mediated macrophage cholesterol efflux in healthyindividuals.” Study confirms that processed foods key to rising obesity University of Sydney (Australia), November 7, 2022 A year-long study of the dietary habits of 9,341 Australians has backed growing evidence that highly processed and refined foods are the leading contributor of rising obesity rates in the Western world. “As people consume more junk foods or highly processed and refined foods, they dilute their dietary protein and increase their risk of being overweight and obese, which we know increases the risk of chronic disease,” said lead author Dr. Amanda Grech, a Postdoctoral Research Fellow at the CPC and the university's School of Life and Environmental Sciences. “It's increasingly clear that our bodies eat to satisfy a protein target,” added Professor David Raubenheimer, the Leonard Ullmann Chair in Nutritional Ecology at the School of Life and Environmental Sciences. “But the problem is that the food in Western diets has increasingly less protein. So, you have to consume more of it to reach your protein target, which effectively elevates your daily energy intake. The University of Sydney scientists analyzed data from a cross-sectional survey of nutrition and physical activity in 9,341 adults, known as the National Nutrition and Physical Activity Survey with a mean age of 46.3 years. They found the population's mean energy intake was 8,671 kilojoules (kJ), with the mean percentage of energy from protein being just 18.4 percent, compared with 43.5 percent from carbohydrates and from 30.9 percent from fat, and just 2.2 percent from fiber and 4.3 percent from alcohol. They also found a statistically significant difference between groups by the third meal of the day: those with a higher proportion of energy from protein at the start of the day had much lower total energy intake for the day. Meanwhile, those who consumed foods low in protein at the start of the day proceeded to increase consumption, indicating they were seeking to compensate with a higher consumption of overall energy. This is despite the fact the first meal was the smallest for both groups, with the least amount of energy and food consumed, whereas the last meal was the largest. Participants with a lower proportion of protein than recommended at the first meal consumed more discretionary foods—energy-dense foods high in saturated fats, sugars, salt, or alcohol—throughout the day, and less of the recommended five food groups (grains; vegetables/legumes; fruit; dairy and meats). Consequently, they had an overall poorer diet at each mealtime, with their percentage of protein energy decreasing even as their discretionary food intake rose—an effect the scientists call ‘protein dilution'. While many factors contribute to excess weight gain—including eating patterns, physical activity levels, and sleep routines—the University of Sydney scientists argue the body's powerful demand for protein, and its lack in highly processed and refined foods, is a key driver of energy overconsumption and obesity in the Western world. Violence on TV: Effects from age 3 can stretch into the teen years University of Montreal, November 7, 2022 Watching violent TV during the preschool years can lead to later risks of psychological and academic impairment by the summer before middle school starts, according to a new study led by Linda Pagani, a professor at Université de Montréal's School of Psycho-Education. Before now, “it was unclear to what extent exposure to typical violent screen content in early childhood—a particularly critical time in brain development—can predict later psychological distress and academic risks,” said Pagani. “The detection of early modifiable factors that influence a child's later well-being is an important target for individual and community health initiatives, and psychological adjustment and academic motivation are essential elements in the successful transition to adolescence,” she added. “So, we wanted to see the long-term effect of typical violent screen exposure in preschoolers on normal development, based on several key indicators of youth adjustment at age 12.” To do this, Pagani and her team examined the violent screen content that parents reported their children viewing between ages 3 1/2 and 4 1/2, and then conducted a follow-up when the children reached age 12. “Compared to their same-sex peers who were not exposed to violent screen content, boys and girls who were exposed to typical violent content on television were more likely to experience subsequent increases in emotional distress,” said Pagani. “They also experienced decreases in classroom engagement, academic achievement and academic motivation by the end of the sixth grade,” she added. “For youth, transition to middle school already represents a crucial stage in their development as adolescents. Feeling sadness and anxiety and being at risk academically tends to complicate their situation.” In all, the parents of 978 girls and 998 boys participated in the study of violent TV viewing at the preschool age. At age 12 years, the children and their teachers rated the children's psychosocial and academic achievement, motivation and participation in classroom activities. “Preschool children tend to identify with characters on TV and treat everything they see as real,” Pagani said. “They are especially vulnerable to humorous depictions of glorified heroes and villains who use violence as a justified means to solve problems. “Repeated exposure,” she added, “to rapidly paced, adrenaline-inducing action sequences and captivating special effects could reinforce beliefs, attitudes and impressions that habitual violence in social interactions is ‘normal.' Mislearning essential social skills can make it difficult to fit in at school.” Added Bernard, “Just like witnessing violence in real life, being repeatedly exposed to a hostile and violent world populated by sometimes grotesque-looking creatures could trigger fear and stress and lead these children to perceive society as dangerous and frightening. And this can lead to habitually overreacting in ambiguous social situations. In the preschool years, the number of hours in a day is limited, and the more children get exposed to aggressive interactions (on screens) the more they might think it normal to behave that way.”
FDA has issued new draft guidance on cybersecurity for software as a medical device (SaMD). If the FDA releases that draft guidance ‘as is,' it will massively and negatively impact the SaMD industry and it's imperative that manufacturers understand how to prepare. In this episode of the Global Medical Device Podcast, Etienne Nichols talks to Chris Gates, director of product security at Velentium, about the shifting sands of medical device cybersecurity regulations for SaMD. Some of the highlights of this episode include:Chris views the FDA's recent activity around cybersecurity requirements, regulations, and laws for SaMD as a necessity because manufacturers cannot seem to self-regulate. The Protecting and Transforming Cyber Health Care Act (PATCH) will give the FDA a direct mandate to manage the cybersecurity of medical devices.However, a clause in the PATCH Act allows for cybersecurity to extend to all existing legacy medical devices—not just new devices entering the market.As medical device manufacturers (MDMs) become aware of the clause, it'll have a huge impact. MDMs will likely end support for device lines due to high costs. The biggest issue with the new guidance consensus vs. regulatory standards is alignment with software bill of materials (SBOM) tools.The most effort-intensive part of the new draft guidance is ongoing testing of anomalies to determine if they can be turned into vulnerabilities. The industry will be unable to keep up with additional testing because of resources and demand.All this added burden will be placed on MDMs at the cost of marginal improvements in cybersecurity. So, there's no real benefit to the manufacturer.Structure a standard by not creating something brand new that is ill/undefined but align best practices to create secure medical devices.Memorable quotes from Chris Gates:“Legally-backed cybersecurity requirements by a regulatory agency are necessary to ensure secure devices are entering the marketplace and hopefully replacing the insecure legacy devices.”“This clause is going to have a huge impact on medical device manufacturers (MDMs) and I find it amazing how many MDMs are completely unaware of this.”“An SBOM is a software bill of materials. It's an ingredients list for your application.”“This isn't just one-and-done testing in your life cycle.”“You're going to have a lot of extra work coming your way.”Links:Medical Device Cybersecurity for Engineers and ManufacturersRegulations (Submit comments to the FDA)Cybersecurity in Medical Devices: Quality System Considerations and Content of Premarket SubmissionsPATCH ActInternational Electrotechnical Commission (IEC)ISO (International Organization for Standardization)International Medical Device Regulators Forum (IMDRF)Chris Gates on LinkedInChris Gates EmailGreenlight Guru YouTube ChannelMedTech True Quality Stories PodcastGreenlight Guru AcademyGreenlight Guru CommunityGreenlight Guru
The CPG Guys, PVSB and Sri are joined in this episode by Mark Detelich Chief Product Officer and Pat Niersbach SVP of Marketing at Syndigo, the first “active content engine” that enables its customers to rapidly assess and modify content to optimize performance using Syndigo's unique integration of analytics throughout the entire product lifecycle.This is the second partnership episode with SyndigoFollow Mark Detelich on LinkedIn at: https://www.linkedin.com/in/mark-detelich-5537714Follow Pat Niersbach on LinkedIn at: https://www.linkedin.com/in/patniersbachFollow Syndigo on LinkedIn at: https://www.linkedin.com/company/syndigo/Follow Syndigo online at: https://www.syndigo.com/ Mark & Pat answer these questions:1) Why is content an important part of omnichannel commerce and why are brands and retailers finding it challenging to manage content at the speed of today's commerce?2) How do brands build trust with their retail customers through accurate & complete product data?3) PIMs, DAMs & MDMs: what are they and how can they create friction in data governance? What is the solution?4) The product content that appears on retail sites is not natively developed by each retailer, it is sourced from brands through syndication. But every channel has different data requirements, and content changes continually. How does Syndigo help solve for this reality?5) Engaging experiences are essential to building customer loyalty and winning the sale both online and in-store. Mark, how should brands be focused on enabling this through product data?6) How do product data analytics and understanding of shopper behavior help improve content that drives conversion?7) Syndigo has recently revealed a new visual brand identity centered around being the first Active Content Engine that powers the continual flow of data and content throughout the entire commerce ecosystem. Help our audience understand this in the context of everything we have been discussing so far.8) Why should brands, retailers and distributors of all sizes be invested in active content and how should they get started?CPG Guys Website: http://CPGGuys.comFMCG Guys Website: http://fmcgguys.comRetailWit Website: http://retailwit.com DISCLAIMER: The content in this podcast episode is provided for general informational purposes only. By listening to our episode, you understand that no information contained in this episode should be construed as advice from CPGGUYS, LLC or the individual author, hosts, or guests, nor is it intended to be a substitute for research on any subject matter. Reference to any specific product or entity does not constitute an endorsement or recommendation by CPGGUYS, LLC. The views expressed by guests are their own and their appearance on the program does not imply an endorsement of them or any entity they represent. CPGGUYS LLC expressly disclaims any and all liability or responsibility for any direct, indirect, incidental, special, consequential or other damages arising out of any individual's use of, reference to, or inability to use this podcast or the information we presented in this podcast.
Teve isso aí que você leu, ninguém fez a pauta dos recadinhos, só lembro que também tinha uma conversa sobre Letronix que não foi pro título. Inclusive, a arte da header foi feita pelo Cinco Horas numa discussão sobre quem venceria uma porradaria franca entre Ursinho Pooh e Bob Esponja. Feed do PODCAST MDMPodcast MdM … The post Podcast MdM #636: Partiu o bonde da BAD VIBE com histórias merdas de infância, Lango-Lango do Demônio, MdMs quase morrendo e a Tesoura Corta Pizza! appeared first on Melhores do Mundo.
Teve isso aí que você leu, ninguém fez a pauta dos recadinhos, só lembro que também tinha uma conversa sobre Letronix que não foi pro título. Inclusive, a arte da header foi feita pelo Cinco Horas numa discussão sobre quem venceria uma porradaria franca entre Ursinho Pooh e Bob Esponja. Feed do PODCAST MDMPodcast MdM … The post Podcast MdM #636: Partiu o bonde da BAD VIBE com histórias merdas de infância, Lango-Lango do Demônio, MdMs quase morrendo e a Tesoura Corta Pizza! appeared first on Melhores do Mundo.
The digitization of the world's economy has accelerated in recent years. The changes brought about by the information age have revolutionized marketing and advertising. A crucial aspect of the sophisticated pipeline structures used by modern businesses is sales development. Pipelines are instrumental to a company's growth, and my guest today has a record of building SDR teams that maximize pipeline potential. With over 25 years of sales and operations experience in the technology sector, Lars Nilsson is a global leader in enterprise software and selling solutions. Currently, he is VP of Global Sales Development at Snowflake and CEO of Sales Source, a premier consulting firm specializing in industry-leading best practices and advisory for optimizing sales teams. Before his time at Snowflake, Lars was VP of Global Inside Sales at Cloudera. Together with his team, they developed the sales methodology known as Account-Based Sales Development (ABSD). It has transformed how many businesses approach their high-value targets. Lars has also worked in sales executive roles at ArcSight/Hewlett Packard, Riverbed Technology, and Portal Software. Listen to today's show, where I spoke with Lars about his successful building sales development teams. Sales Development Versus Business Development Sales and business development sometimes seem like they can mean the same thing. I asked Lars whether he distinguishes the two. He told me that some companies would choose to have hybrid teams, but more mature teams will segment them. “If you're just starting, the odds are your SDR is doing both inbound and outbound,” he said. Lars pointed to Salesforce.com as an example of a company that has segmented business development and sales development. Their sales development team are newer hires and handle inbound leads from internal channels. They can later graduate into business development. There, they take outbound cold prospecting. As a minor operation, our reps get market development by mixing in some closing experience as part of their daily routine. When sales development reps have two roles to fill, they can naturally lean toward one or the other and need to be managed more closely. Lars mentioned that he thinks sales development positions should have a clear progression path into carrying a quota. Listen to our entire episode to hear all of his thoughts on balancing the two functions. Optimizing Density Coverage Sales development's role is to find opportunities for their quota-carrying counterparts. They want meetings with the right people at the right time. But how do you find the correct ratio of SDRs to AEs? Lars recalled his time working with Portal Software. His manager, Bernie Scomra, realized that his reps would need to prospect and close to support the pipeline they had started. He asked Lars to design a team so that his salespeople would not have to prospect. That was in 1997, and at the time, the ratio was one sales development rep to every five account executives. “Imagine one SDR managing the personalities and the schedules of five AEs. You don't get the efficiency,” he said. There are now 20 years of data and studies on different companies' SDR. Lars says one SDR per three AEs is a good standard for mid-market enterprises. A one-to-one ratio is generous, but the payoff is more pipeline than you would ever imagine at one-to-three. Procore is an example of a company that turned its pipeline growth around by going even further. For a time, they had two sales development representatives for every one account executive. Tune in to the podcast to hear more about our experiences fine-tuning SDR to AE density within our teams. The Role of SDR Managers What kind of coaching and training should the frontline manager focus on? The onboarding programs that sales development reps have to absorb at the entry-level are denser than in the past. SDR managers often bear responsibility for supporting the process. Lars said there needs to be support networks outside of the SDR manager for efficient frontline operations. “In my opinion, you need a lot more dedicated ops for SDRs than you do for account execs.” The frontline SDR manager shouldn't need to serve as much of a training and onboarding function. More room for them to work together on the line with new hires is more efficient. They need time to lean in and give some over-the-shoulder coaching. SDR teams supported by reliable operations are what Lars calls the most lethal pipeline generators. Hear what Lars had to say about what he looks for as the best predictor for future success in a new hire by listening to the whole discussion. SDR Marketing Integration I was surprised to learn that at Snowflake, Lars' SDR team also works closely on the company's marketing model. The company uses what is called Account Based Marketing. That means that they focus and segment their salesforce into groups that target specific accounts as a company. A dedicated function works to develop innovative campaigns that reach out to targeted personas and companies globally. By tying sales and marketing together more closely, their campaigns are more efficient and avoid common mistakes that are simply the result of sales and marketing teams adopting principles independently of one another. “I think that's probably one of the bigger disconnects. When I look back at my career at all the dysfunction that happened... teams didn't spend a lot of time together,” he said. I asked Lars if the new approach had led to any change in compensation design at Snowflake. He said there were no compensation changes for the sales development team but that the marketing organization had pipeline generation goals. Check out the complete audio and hear more about how Snowflake uses a shared CRO to tie its sales and market teams together. Performance Targets for SDR Teams In April of this year, my company did a study asking our reps what the most challenging part of selling was and 69% answered prospecting. We've been evaluating who we assign the prospecting role to and are closely watching how our compensation plan ties our MDMs' performance to a revenue number for their region. Lars and I spoke about what model Snowflake uses to set performance targets. They primarily look at the number of meetings and how many wind up as qualified opportunities in the pipeline. While their metrics are weighted toward the number of meetings, it's better to base them on meeting alone supplemented by spiffs for opportunities and closed deals. “Tying comp and reaching quota to something that you have very little control over or no control over is a pain point,” he said. “It's still at the end of the day up to the account executives whether or not they're going to put it into their pipeline.” I asked him what the compensation is per meeting at Snowflake. He estimates that their plan yields sales development reps approximately $150 to $200 and is based on a monthly quota with a range between 12 and 22 meetings. Play the entire episode to hear everything Lars says about Snowflake's growth strategy and what strategies he's employing to grow his global sales development team.
ETV Bharat Karnataka news in kannada for June 4 2021 7am is about Karnataka High Court directed state government to provide grains instead of food in MDMS, PM Modi speaks to US Vice President Kamala Harris over vaccine supplies to India, Milkha Singh admitted to ICU of Chandigarh hospital due to dipping levels of oxygen, Washington bars US investors from 59 Chinese companies as national security measure and several other news, for more live news download Etv Bharat Download ETV Bharat on App store – https://apps.apple.com/in/app/etv-bharat/id1453416186 Play Store – https://play.google.com/store/apps/details?id=com.etvbharat.android Or watch us live on – www.etvbharat.com ETV Bharat is d Division of Ushodaya Enterprises Pvt. Ltd. , is a comprehensive digital national news platform conceived to deliver seamless news and information services, using video-centric Mobile App and Web Portals. It is first-of-its kind offering in India in terms of diversity and depth, dedicated journalists network, reach of 24 states with services in 13 languages i.e.– Hindi, Urdu, Telugu, Tamil, Kannada, Malayalam, Gujarati, Marathi, Bengali, Punjabi, Assamese, Odia and English. ETV Bharat is the latest initiative of the five-decade old multi-dimensional Ramoji Group. The Group's highly successful media endeavors include : Eenadu - one of the largely circulated language dailies in the country , and ETV Network with Telugu general entertainment, infotainment and news channels. With a strong lineage of the most trusted media house, ETV Bharat would draw on its strengths of decades' long experience and innovation. ETV Bharat will combine the new technologies of mobile and digital media to engage news and information seekers in a new connected world. It will be driven by well-established news gathering setup, technology specialists and other professionals.
Host Jeremy Cherny interviews Max Palzewicz, Director of Operations at Rocketman Tech “I started out my career in public accounting, primarily working and advising small business owners. I got my CPA and I was able to join my dad and uncle's business coaching firm, Action Coach of Southeastern Wisconsin, where I worked for a few years. I carved out a niche for myself focusing on the financials for business owners, teaching business owners, how to be financially literate, how to read and analyze their financial statements, also how to process good numbers so they could make sound decisions with them. After that chapter, I realized I wanted to actually do it myself and I wanted to go out and prove that I could build a business on my own. A friend tossed out the idea to me in late 2018, that I should learn how to implement a software called Jamf Pro. What they do is they have a mobile device management software that specializes in Apple devices, so Mac OS, and iOS. So that's what we started doing and I got certified to implement the software. But something happened in early 2019, where Jamf Pro stopped requiring the onboarding engagement for clients to use the software. So our whole business model of doing these one-off software implementations had been turned on its head. What we did instead was we turned his Rolodex of 200 or so companies and we turned it into a CRM, and we started email marketing. From that, I realized that not only was his skill set highly sought after, but these system administrators that are Mac OS specific also make upwards of six figures or more in a lot of businesses that they work in. So it's a sought after skill and position, but it's also highly transferable where people are frequently job-hopping in this space and they tend to leave in that wake of procedures that were poorly documented because it was in their job security, it was in their best interest to do everything themselves in the Mac OS management space and not really document well. We realized there was a great need for a service IT company to specialize in this. A lot of IT companies try to be all things to all people so they'll do an entire vertical of services for their clients. We decided to just focus on this one thing, and that was managing Apple devices for enterprise companies.” I don't know if all our listeners know exactly what mobile device management is nor where it fits in with security. Can you say a bit more about that? MDM (Mobile Device Management) is kind of one of those pillars that you look for when you do a SOC to a compliance test or any of those security benchmarks or standards, whether you're getting a SOC to audit, or an ISO 27001 audit, or if you're just trying to follow the CIS benchmarks. Generally, you need mobile device management software to meet that compliance framework. So where MDM comes in, and Jamf Pro specifically is it's a software that's designed to interact with the management framework on iOS and Mac OS devices. So it allows IT to remotely interact and provision these devices so you can push down things like configuration profiles, where you might interact with System Preferences. You can also push out policies where you're deploying software or deploying different objects to the computers. But the whole idea is to allow IT to remotely interact at scale, with hundreds of thousands of devices so they don't have to do the old sneakernet of going around and troubleshooting each device individually. What about mobile device management has improved security for people? Security is always evolving, how does Rockinman Tech stay on top of those security threats? What we've noticed is the modern standard for enterprise, especially in this remote work environment, is to move towards something called zero-touch deployment with a cloud identity provider through your MDM. So what most of these enterprise companies are doing and I mean, the market share tends to lean heavily towards Microsoft Azure AD for Cloud Identity. There are probably five or six other major players in there, Google has one, Ping has one, OKTA is a great one for startups and smaller companies. But Azure AD seems to be the gold standard for the fortune 500. Conversely, for Apple device management, Jamf Pro seems to be the best in class for managing Mac OS. So all these companies are striving towards this goal that's just barely out of reach, called zero-touch deployment. The reason it's out of reach is that they have security teams that were initially developed to manage a primarily Windows environment. But what we've seen over the last couple of decades, with executives, marketing teams, design teams, and then different developers, you start to have an influx of Mac OS, computers in the enterprise space, and you still need to have those computers be in compliance and be secure when they're connecting to the local area network or VPN, or just using sensitive information. But what we've seen is as we onboard those first few hundred computers that are Macs and not Windows PCs, it creates kind of a wild west environment. So the security team that was used to managing the Windows environment is trying to extrapolate or apply those windows requirements for the Apple devices or Mac OS computers. We find that in some cases that isn't quite appropriate, and it can cause some snags and that goal of getting to zero-touch. What's an example of something that gets in the way of that, which would be a Windows thing that doesn't apply to the world of Mac? I think that's a good segue into what are the differences between Mac OS and Windows when you talk about security because a lot of antivirus and malware and firewall stuff has been created for the Windows environment. Whereas Mac OS has a number of built-in security features that are unique to them which are built-in, meaning they don't need third party software to operate effectively. So for firewalls, Windows will use McAfee, you'll use the web proxy and the agent. But Mac OS has a built-in network firewall. On the windows side, you might use something called a Kaspersky to scan applications you download from the internet. Mac OS has something called gatekeeper that checks for a developer certificate and then checks now for a notarisation from Apple too. You might have malware removal and protection. So something like Symantec for Windows, Apple has X Protect that's already built into the framework and that will detect and download files and scan for malware as it comes in. Bitdefender is a market leader on the Windows side too for interacting with the management framework of Windows. Apple has system integrity protection so that third-party software can't really modify or overwrite any system files. That's where we saw kernel extensions with High Sierra 10.13 and system extensions now with Catalina. What are you seeing as the future of information security? That's a great question that can go in a number of directions. At least for the Apple side, I see that Apple devices will continue to gain market share, and prevalence in enterprise environments because generally, our workforce is growing for the millennial cohort and that cohort tends to lean more heavily to wanting to use a Mac versus a PC. That's basically what we've done for a lot of these enterprise companies is we've created that proof of concept for the first 50 to 200, or 300 Macs to say, "Hey, these can work in your environment, and they can work securely, and they're going to improve productivity in the long run, because you're going to have fewer helpdesk tickets, and your users are going to be more satisfied." So number one, I see that trend is going to Apple is going to continue to gain market share in the enterprise space, because they've probably tapped out the consumer in terms of what they can sell to them. I'm sure they've got a few more tricks up their sleeve, but I think this is really the next frontier for them. That's also what we see in the MDM landscape because Jamf Pro seized that monopolistic market share at first. But now we see these other companies like Addigy and Kandji, starting to get funding and create MDMs that are similar, if not better than Jamf Pro and start to chip away at that market share. So those are a couple of trends I see continuing, more globally. This might be a hot take, based on what we've seen with the congressional hearings and big tech, but I can see Azure, potentially being split off from Amazon and Microsoft respectively, being separate companies. The same Telecom and Internet. Those companies have been trying to merge for years because they want to gain those efficiencies. I think it's very possible that Telecom, Internet, 5g and cloud hosting all that storage becomes more closely resembled a public utility. Because it might just be in the public's best interest to allow those to operate as monopolies. But they would have to more closely resemble public utility then. Do you have any other side projects or fun activities besides Rocketman Tech you would like to share? I've always been kind of enamored with creating something that can work without you. For the most part, I've done that with my role at Rockman by handing over the business development and sales to someone else, recruiting and onboarding another engineer to help with the project management, and the execution of projects. So for about the last 10 months, I've been kind of acting as a scrum master on a startup that has been making a mobile app for the music industry. It's an app that functions similar to Google Calendar, but it allows users to be on the same calendar domain so different users can see each other's availability, and then create events and schedule with each other. I'm a musician on the side too, I play saxophone and keys. So I wanted to create something that would make our lives a lot easier for networking. So I've been acting as a scrum master, where I kind of lead the designer and developer and product owner to get the app, stable, free of bugs, develop new features, consider the user design, and the feedback there. Now we're looking at releasing it on the App Store and Google Play probably in quarter 2 of 2021 right around when the weather starts turning again, and we see music happening outside again in the Midwest.
Created with GIMP No podcast de hoje temos a continuação do RPG Call of Cthulhu. No segundo bloco, Nerd Reverso e Change falam sobre a nova animação dos DuckTales. No terceiro bloco, Mallandrox faz um review sobre o gibi dos Três Coringas. E na leitura de comentários, os MdMs elegem o Top 3 de uma …
Created with GIMP No podcast de hoje temos a continuação do RPG Call of Cthulhu. No segundo bloco, Nerd Reverso e Change falam sobre a nova animação dos DuckTales. No terceiro bloco, Mallandrox faz um review sobre o gibi dos Três Coringas. E na leitura de comentários, os MdMs elegem o Top 3 de uma … The post Podcast MdM #594: RPG + DuckTales + 3 Corongas + Top 3 de um monte de coisas appeared first on Melhores do Mundo.
Epidemiology · A case report of a 29-year-old SARS-CoV-2 positive woman with minimal, mild symptoms who underwent an uncomplicated and successful vaginal delivery revealed the following in the placenta: 1. Evidence of general placental vascular malperfusion possibly due to hypertrophic arteriolopathy; notably, there were no signs of fetal malperfusion or micro-thrombi and 2. Presence of SARS-CoV-2 in chorionic villi endothelial cells. The authors posit that this case is the first report of placental SARS-CoV-2 in the setting of mild COVID-19 disease, where the patient had only symptoms of mild myalgias. · In comparing hematological features in COVID-19 positive (n=30) and negative (n=40) children presenting to the emergency department in City Hospital Ankara, Turkey with symptoms of fever, cough, rhinorrhea, and sore throat, COVID-19 positive patients demonstrated neutrophils with lobulation abnormalities, vacuolated monocytes and lowered neutrophil and leukocyte counts (p=0.02). The lack of thrombocytopenia in children with COVID-19 may be responsible for the improved outcomes observed in children. Understanding the Pathology · Findings from an in-vitro study by authors affiliated with the University of Hong Kong and Hainan Medical University investigating the viral protein expression, replication kinetics, and host response in monocyte-derived dendritic cells (moDCs) and monocyte-derived macrophages (MDMs) upon infection by SARS-CoV-2 suggest that SARS-CoV-2-infected moDCs and MDMs in the lungs of COVID-19 patients may be a source of pro-inflammatory cytokine production, exacerbating the COVID-19 manifestation. R&D: Diagnosis & Treatments · A prospective study conducted at a Malaysian COVID-19 quarantine center of 217 asymptomatic adult males, where 160 tested positive, found a far greater SARS-CoV-2 detection rate using morning salivary samples (93.1%) when compared to nasopharyngeal swabs (52.5%) (p
No podcast a galera do MdM games recebe Rafael Quina, do Jogabilidade, para falarem por quatro horas seguidas do remake de Final Fantasy 7. Também temos no segundo bloco o episódio perdido do RPG MdM E na leitura de comentários os MdMs ficam nas salas de bate-papo UOL. Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #574: Final Fantasy 7 + RPG + MdMs nas salas de bate-papo UOL appeared first on Melhores do Mundo.
No podcast a galera do MdM games recebe Rafael Quina, do Jogabilidade, para falarem por quatro horas seguidas do remake de Final Fantasy 7. Também temos no segundo bloco o episódio perdido do RPG MdM E na leitura de comentários os MdMs ficam nas salas de bate-papo UOL. Feed do PODCAST MDMPodcast MdM no Spotify
In this episode, host Dr. Gregg Sherman and NACE expert faculty member, Lucia M. Novak, MSN, ANP-BC. BC-ADM, discuss Optimizing Outcomes in Diabetes With GLP-1 Therapy. Dr. Sherman and Ms. Novak discuss the glycemic and cardiorenal effects of GLP-1 RAs, the differences between injectable and oral GLP-1 RA formulations, and strategies for integrating GLP-1 RA therapy into earlier therapeutic decision-making, based on the newest treatment. About Lucia M. Novak, MSN, ANP-BC. BC-ADMPresident and Owner, Diabetes Consulting Services, Rockville, MDDiabetes Expert, Diabetes & Endocrine Associates, Silver Spring, MDMs. Novak is a board-certified nurse practitioner in both Adult Health and Advanced Diabetes Management and has over 17 years of clinical, research and educational experience in diabetes mellitus. Ms. Novak has provided her expertise pertaining to diabetes as a Contributing Author for the Lippincott Manual of Nursing Practice for the last 4 editions and is also a Contributing Author for the 1st edition of Genomic Essentials for Graduate Level Nurses. Ms. Novak serves as an Associate Editor for Clinical Diabetes. Ms. Novak has been repeatedly recognized for her outstanding contributions as a clinician, researcher and educator. In 2015, she was designated Master Clinician for her proven leadership and clinical prowess, an accolade that placed her among the top 2% of the health care providers of the Walter Reed National Military Medical Center and is also a recipient of The DAISY Foundation Award for Extraordinary Nurses. Her nearly 28 years of nursing experience include active duty service as a Commissioned Officer of the United States Army Nurse Corps. This podcast episode is supported by an independent medical education grant from Novo Nordisk. This activity is not certified for CME/CE credit.
No podcast de hoje temos o primeiro bloco sobre o confirmado Snyder Cut, onde os MdMs falam sobre toda a história do Zack Snyder na DC. No segundo bloco as MdManas recebem Veronica Oliveira para fazer o Faxinão MdM, com dicas para limpeza da casa e também sobre os melhores vibradores. E no último bloco …
No podcast de hoje temos o primeiro bloco sobre o confirmado Snyder Cut, onde os MdMs falam sobre toda a história do Zack Snyder na DC. No segundo bloco as MdManas recebem Veronica Oliveira para fazer o Faxinão MdM, com dicas para limpeza da casa e também sobre os melhores vibradores. E no último bloco … The post Podcast MdM #571: Snyder Cut + Faxina + Vibradores + Snyder Cut de novo! appeared first on Melhores do Mundo.
No podcast de hoje os MdMs do MdMangá falam sobre os animes da temporada. Isso você já leu no título. Feed do PODCAST MDMPodcast MdM no Spotify
No podcast de hoje os MdMs do MdMangá falam sobre os animes da temporada. Isso você já leu no título. Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #570: Beastars, Tower of God, Sing Yesterday for Me, Extra Olympia Kyklos e os animes da temporada appeared first on Melhores do Mundo.
No podcast de hoje os MdMs recebem o Caio San, do Refogado podcast, para lembrarem das comidas toscas que mais gostam! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #567: Comidas Toscas! appeared first on Melhores do Mundo.
No podcast de hoje os MdMs recebem o Caio San, do Refogado podcast, para lembrarem das comidas toscas que mais gostam! Feed do PODCAST MDMPodcast MdM no Spotify
No Podcast MdM de hoje os MdMs recebem Afonso Andrade, coordenador do FIQ, para falar sobre o adiamento do evento devido ao Coronavírus. No segundo bloco a galera do MdM Games relembra todos os jogos de 2013. E mais: Recadinhos, Comentários e Estatísticas MdM! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #562: O Adiamento do FIQ 2020 + MdMGames e os jogos de 2013 appeared first on Melhores do Mundo.
No Podcast MdM de hoje os MdMs recebem Afonso Andrade, coordenador do FIQ, para falar sobre o adiamento do evento devido ao Coronavírus. No segundo bloco a galera do MdM Games relembra todos os jogos de 2013. E mais: Recadinhos, Comentários e Estatísticas MdM! Feed do PODCAST MDMPodcast MdM no Spotify
No Podcast de hoje os MdMs se juntam com a galera da Mansão Wayne, Caverna do Morcego e Hora Suave para relembrar os piores e melhores momentos do Robin, que completa 80 anos em 2020! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #561: Robin, o menino de 80 anos de idade appeared first on Melhores do Mundo.
No Podcast de hoje os MdMs se juntam com a galera da Mansão Wayne, Caverna do Morcego e Hora Suave para relembrar os piores e melhores momentos do Robin, que completa 80 anos em 2020! Feed do PODCAST MDMPodcast MdM no Spotify
No podcast de hoje os MdMs relembram os filmes, séries e personagens que a galera ENTENDEU ERRADO! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #560: Viu, mas não entendeu… Burro pra caralho você! appeared first on Melhores do Mundo.
No podcast de hoje os MdMs relembram os filmes, séries e personagens que a galera ENTENDEU ERRADO! Feed do PODCAST MDMPodcast MdM no Spotify
No podcast de hoje os MdMs fazem as suas apostas para o oscar! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #556: As nossas apostas (merdas) para o Oscar! appeared first on Melhores do Mundo.
No podcast de hoje os MdMs fazem as suas apostas para o oscar! Feed do PODCAST MDMPodcast MdM no Spotify
No podcast de hoje od MdMs, motivados pelo filme do merda do Morbius, escolhem outros heróis merdas que poderiam ir para os cinemas! No segundo bloco, as MdManas lembram como foi 2019 e o que esperam para 2020! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #553: Fazendo um filme com personagens merdas + as resoluções de 2020 appeared first on Melhores do Mundo.
No podcast de hoje od MdMs, motivados pelo filme do merda do Morbius, escolhem outros heróis merdas que poderiam ir para os cinemas! No segundo bloco, as MdManas lembram como foi 2019 e o que esperam para 2020! Feed do PODCAST MDMPodcast MdM no Spotify
No podcast de hoje os MdMs descem o cacete no novo filme de Star Wars! FELIZ NATAL, SEU ARROMBADO! Feed do PODCAST MDMPodcast MdM no Spotify
No podcast de hoje os MdMs descem o cacete no novo filme de Star Wars! FELIZ NATAL, SEU ARROMBADO! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #550: Metendo a Porrada no novo filme de Star Wars appeared first on Melhores do Mundo.
RÁÁÁÁÁ!!! No podcast de hoje os intrépidos MdMs (que eu não lembro quem eram) relembram os filmes de 2019, elencando suas listas de melhores, piores, os que cagamos, os que nem vimos e mesmo assim falamos mal, e os que vimos no avião!!! Tem também leitura de comentários, recadinhos e estatísticas MdM… AAAAHHHH, E NÃO …
RÁÁÁÁÁ!!! No podcast de hoje os intrépidos MdMs (que eu não lembro quem eram) relembram os filmes de 2019, elencando suas listas de melhores, piores, os que cagamos, os que nem vimos e mesmo assim falamos mal, e os que vimos no avião!!! Tem também leitura de comentários, recadinhos e estatísticas MdM… AAAAHHHH, E NÃO … The post Podcast MdM #549: Filmes de 2019: Os melhores, os piores, os para os quais cagamos e os que vimos no avião appeared first on Melhores do Mundo.
No podcast de hoje os MdMs falam sobre uma porrada de coisas sem sentido nenhum! Ou seja, uma sexta-feira como qualquer outra! E mais: Recadinhos, comentários e as infames Estatísticas MdM! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #545: Yoda transando, aquele robozinho que limpa a casa, etc. appeared first on Melhores do Mundo.
No podcast de hoje os MdMs falam sobre uma porrada de coisas sem sentido nenhum! Ou seja, uma sexta-feira como qualquer outra! E mais: Recadinhos, comentários e as infames Estatísticas MdM! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #545: Yoda transando, aquele robozinho que limpa a casa, etc. appeared first on Melhores do Mundo.
Salve nerdaiada maldita… No podcast parque temático de hoje os intrépidos MdMs discutem sobre os assuntos nerds mais importantes que povoaram as rodas de papo dessa semana, e obóviamente que o papo seguiu sem foco nenhum e cheio de offtopics. Temos também leitura de comentários e as famigeradas estatísticas MdM Feed do PODCAST MDMPodcast MdM … The post Podcast MdM #542: Scorsese, Coppolla, Trailer de Star Wars, Watchmen e foda-se appeared first on Melhores do Mundo.
Salve nerdaiada maldita… No podcast parque temático de hoje os intrépidos MdMs discutem sobre os assuntos nerds mais importantes que povoaram as rodas de papo dessa semana, e obóviamente que o papo seguiu sem foco nenhum e cheio de offtopics. Temos também leitura de comentários e as famigeradas estatísticas MdM Feed do PODCAST MDMPodcast MdM … The post Podcast MdM #542: Scorsese, Coppolla, Trailer de Star Wars, Watchmen e foda-se appeared first on Melhores do Mundo.
No podcast MdM de hoje os MdMs falam sobre quais foram os últimos brinquedos que eles ganharam antes de virarem ADULTINHOS! Tudo isso numa conversa amigável, cheia de patadas e coices! E VOLTA A LOJA DE FERRADURAS MDM! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #538: Os nossos últimos brinquedos no podcast LOJA DE FERRADURAS MDM! appeared first on Melhores do Mundo.
No podcast MdM de hoje os MdMs falam sobre quais foram os últimos brinquedos que eles ganharam antes de virarem ADULTINHOS! Tudo isso numa conversa amigável, cheia de patadas e coices! E VOLTA A LOJA DE FERRADURAS MDM! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #538: Os nossos últimos brinquedos no podcast LOJA DE FERRADURAS MDM! appeared first on Melhores do Mundo.
No podcast de hoje os MdMs relembram aqueles filmes de heróis que caíram no esquecimento: Tartarugas Ninja, Darkman, Sombra, Fantasma, Dick Tracy, Rocketeer, etc. E mais: offtopics pra caralho, recadinhos, comentários e estatísticas MdM! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #536: Os filmes de super-heróis que (quase) esquecemos appeared first on Melhores do Mundo.
No podcast de hoje os MdMs relembram aqueles filmes de heróis que caíram no esquecimento: Tartarugas Ninja, Darkman, Sombra, Fantasma, Dick Tracy, Rocketeer, etc. E mais: offtopics pra caralho, recadinhos, comentários e estatísticas MdM! Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #536: Os filmes de super-heróis que (quase) esquecemos appeared first on Melhores do Mundo.
AHÁÁÁÁÁAÁ!!! Vocês que acharam que o papo sobre quadrinhos não iria continuar, ACHOU ERRADO OTÁÁÁRIO!!! Os intrépidos MdMs relembram qual a sensação de ler, pela primeira vez, quadrinhos para adultos. eed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #534: Sussurros espectrais e nossa passagem das HQs juvenis pro quadrinho adulto appeared first on Melhores do Mundo.
AHÁÁÁÁÁAÁ!!! Vocês que acharam que o papo sobre quadrinhos não iria continuar, ACHOU ERRADO OTÁÁÁRIO!!! Os intrépidos MdMs relembram qual a sensação de ler, pela primeira vez, quadrinhos para adultos. eed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #534: Sussurros espectrais e nossa passagem das HQs juvenis pro quadrinho adulto appeared first on Melhores do Mundo.
No podcast de hoje os MdMs relembram histórias da época de criança, porque o mundo tá MUITO COMPRICADO Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #533: Um Podcast escapista, já que o mundo tá uma merda só appeared first on Melhores do Mundo.
No podcast de hoje os MdMs relembram histórias da época de criança, porque o mundo tá MUITO COMPRICADO Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #533: Um Podcast escapista, já que o mundo tá uma merda só appeared first on Melhores do Mundo.
No podcast MdM de hoje era pra ter um tema mas uma mesa com uns 13 MdMs começaram a falar de um monte de coisas aleatórias Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #532: a vida e obra do Variguinho appeared first on Melhores do Mundo.
No podcast MdM de hoje era pra ter um tema mas uma mesa com uns 13 MdMs começaram a falar de um monte de coisas aleatórias Feed do PODCAST MDMPodcast MdM no Spotify The post Podcast MdM #532: a vida e obra do Variguinho appeared first on Melhores do Mundo.
No primeiro bloco do podcast temos os MdMs falando sobre as notícias da Comic Con… Só que eles falaram sobre pessoas que se vestem de cavalo, terraplanistas, celebridades anti-vacinas e o cachorrinho fiadaputa. No segundo bloco o MdM mais um monte de convidados falam sobre os novos Cavaleiros do Zodíaco da Netflix No terceiro bloco … The post Podcast MdM #529: Notícias da Comic Con + Cavaleiros do Zodíaco + Data Limite + Cachorrinho Fiadaputa em 8h30 de podcast! appeared first on Melhores do Mundo.
No primeiro bloco do podcast temos os MdMs falando sobre as notícias da Comic Con… Só que eles falaram sobre pessoas que se vestem de cavalo, terraplanistas, celebridades anti-vacinas e o cachorrinho fiadaputa. No segundo bloco o MdM mais um monte de convidados falam sobre os novos Cavaleiros do Zodíaco da Netflix No terceiro bloco … The post Podcast MdM #529: Notícias da Comic Con + Cavaleiros do Zodíaco + Data Limite + Cachorrinho Fiadaputa em 8h30 de podcast! appeared first on Melhores do Mundo.
Na primeira parte do pod temos os MdMs recebendo os chégas Load e Andrei Fernandes pra um review sobre o filme Homem-Aranha Longe de Casa. Saiu PORRADA NESSA GRAVAÇÃO! No segundo bloco, as MDManas Dea (@deamelo), Belle (@bellefelix), Júlia (@yaholy), Cris (@crispistola) e Adriana(@adriana_melo) se juntaram pra falar de uma nobre atividade: o Trabalho! Já … The post Podcast MdM #528: Saiu PORRADA no papo sobre o Homem-Aranha + MdManas em Horário Comercial em SETE HORAS de podcast! appeared first on Melhores do Mundo.
Na primeira parte do pod temos os MdMs recebendo os chégas Load e Andrei Fernandes pra um review sobre o filme Homem-Aranha Longe de Casa. Saiu PORRADA NESSA GRAVAÇÃO! No segundo bloco, as MDManas Dea (@deamelo), Belle (@bellefelix), Júlia (@yaholy), Cris (@crispistola) e Adriana(@adriana_melo) se juntaram pra falar de uma nobre atividade: o Trabalho! Já … The post Podcast MdM #528: Saiu PORRADA no papo sobre o Homem-Aranha + MdManas em Horário Comercial em SETE HORAS de podcast! appeared first on Melhores do Mundo.
Pois é, nerdaiada maldita, nesse podcast de mais de CINCO HORAS E MEIA, temos diversos MdMs comentando sobre o desfile das escolas de samba do Rio e outra leva de diversos MdMs falando sobre cancelamentos de HQs, fechamento de lojas, retração de mercado e também conjecturando a possibilidade do FIM DAS HQS!!!! Ainda temos recadinhos, … The post Podcast MdM #510: MdMomo no Carnaval e o fim das HQs appeared first on Melhores do Mundo.
Pois é, nerdaiada maldita, nesse podcast de mais de CINCO HORAS E MEIA, temos diversos MdMs comentando sobre o desfile das escolas de samba do Rio e outra leva de diversos MdMs falando sobre cancelamentos de HQs, fechamento de lojas, retração de mercado e também conjecturando a possibilidade do FIM DAS HQS!!!! Ainda temos recadinhos, … The post Podcast MdM #510: MdMomo no Carnaval e o fim das HQs appeared first on Melhores do Mundo.
Olarrr nerdaiada maldita… no podcast de hoje temos os intrépidos MdMs (que eu não lembro quem eram) discutindo notícias da semana retrasada (de um pod que ficou pra trás e resolvemos publicar hoje) e falando merda como sempre, na outra parte do programa temos a galera do MdMangá: Lojinha, Maximus, Tango, Belle, Ju Mattos, 5 … The post Podcast MdM #474: E ai pessoal da rede + Os Animes da TV Brasileira II – A Missão appeared first on Melhores do Mundo.
Olarrr nerdaiada maldita… no podcast de hoje temos os intrépidos MdMs (que eu não lembro quem eram) discutindo notícias da semana retrasada (de um pod que ficou pra trás e resolvemos publicar hoje) e falando merda como sempre, na outra parte do programa temos a galera do MdMangá: Lojinha, Maximus, Tango, Belle, Ju Mattos, 5 … The post Podcast MdM #474: E ai pessoal da rede + Os Animes da TV Brasileira II – A Missão appeared first on Melhores do Mundo.
Olarrr nerds malditos… Na semana passada a DC divulgou a “nova” formação da Liga da Justiça, e com base nisso os intrépidos MdMs resolveram fazer um AAAARQUIVOOOO CONFIDENCIAAAALLL do grupo, falando sobre suas fases preferidas, fases bostas, melhores formações, equipes criativas, heróis que deveriam ter feito parte do grupo e outros que nunca deveriam ter … The post Podcast MdM #458: AAAARQUIVOOOO CONFIDENCIALLL, GALERAAAAA!!! Liga da Justiça! appeared first on Melhores do Mundo.
Olarrr nerds malditos… Na semana passada a DC divulgou a “nova” formação da Liga da Justiça, e com base nisso os intrépidos MdMs resolveram fazer um AAAARQUIVOOOO CONFIDENCIAAAALLL do grupo, falando sobre suas fases preferidas, fases bostas, melhores formações, equipes criativas, heróis que deveriam ter feito parte do grupo e outros que nunca deveriam ter … The post Podcast MdM #458: AAAARQUIVOOOO CONFIDENCIALLL, GALERAAAAA!!! Liga da Justiça! appeared first on Melhores do Mundo.
No podcast de hoje os MdMs se juntam pra analisarem os filmes de 2017 seguindo as seguintes categorias: 1) Melhores filmes de 2017 2) Filmes mais merdas 3) Nao vi e não gostei 4) Queria ter visto, mas não vi 5) Menções honrosas Social The post Podcast MdM #445: A suruba de replicantes e os melhores e mais merdas filmes de 2017 appeared first on Melhores do Mundo.
No podcast de hoje os MdMs se juntam pra analisarem os filmes de 2017 seguindo as seguintes categorias: 1) Melhores filmes de 2017 2) Filmes mais merdas 3) Nao vi e não gostei 4) Queria ter visto, mas não vi 5) Menções honrosas Social The post Podcast MdM #445: A suruba de replicantes e os melhores e mais merdas filmes de 2017 appeared first on Melhores do Mundo.
No podcast de hoje Change, Hell, Maximus, Adriana Melo, Nerd Reverso, Nasic e Dudu Sales fazem um review de Thor: Ragnarok. E aí? Será que é essa Coca-Cola toda? Será que os MdMs vão descer o pau no filme e todos os marvetinhos vão ficar bolados? DESCUBRA! Social Comentado no Podcast: Catarse do gibi Acelera … The post Podcast MdM #437: O filme do Thor é legal MAS O MDM ODIOOOOOOOOU! appeared first on Melhores do Mundo.
No podcast de hoje Change, Hell, Maximus, Adriana Melo, Nerd Reverso, Nasic e Dudu Sales fazem um review de Thor: Ragnarok. E aí? Será que é essa Coca-Cola toda? Será que os MdMs vão descer o pau no filme e todos os marvetinhos vão ficar bolados? DESCUBRA! Social Comentado no Podcast: Catarse do gibi Acelera … The post Podcast MdM #437: O filme do Thor é legal MAS O MDM ODIOOOOOOOOU! appeared first on Melhores do Mundo.
Salve Nerdaiada maldita… No programa de hoje os MdMs Change e Hell se juntam aos MdMs da Costa Oeste Daniel HDR, Marcio Fiorito e Fernando Caruso só pra lerem os comentários dos leitores do site (no facebook) e responder suas perguntas sobre os acontecimentos nerds recentes… E ainda as estatísticas MdM respondem quantos MILTONS de … The post Podcast MdM #436 Um programa só com LEITUUURAAA DE COMENTÁÁÁRIOOSSS!!! AHEUAHEUAEHAUE appeared first on Melhores do Mundo.
Salve Nerdaiada maldita… No programa de hoje os MdMs Change e Hell se juntam aos MdMs da Costa Oeste Daniel HDR, Marcio Fiorito e Fernando Caruso só pra lerem os comentários dos leitores do site (no facebook) e responder suas perguntas sobre os acontecimentos nerds recentes… E ainda as estatísticas MdM respondem quantos MILTONS de … The post Podcast MdM #436 Um programa só com LEITUUURAAA DE COMENTÁÁÁRIOOSSS!!! AHEUAHEUAEHAUE appeared first on Melhores do Mundo.
No podcast de hoje Hell, Change, Adriana Melo, Fiorito, Lojinha, Maximus, Triplo, Leo Finocchi e Felipe 5 Horas começam a série de episódios de RPG. No capítulo de hoje os MdMs vão criar seus personagens de forma randomizada: todos seus poderes, talentos, origem e atributos vão ser gerados randomicamente. SPOILER: só tem personagem MERDA!!! Social … The post Podcast MdM #434: Os MdMs jogam o RPG da MARVEL dos anos 80! appeared first on Melhores do Mundo.
No podcast de hoje Hell, Change, Adriana Melo, Fiorito, Lojinha, Maximus, Triplo, Leo Finocchi e Felipe 5 Horas começam a série de episódios de RPG. No capítulo de hoje os MdMs vão criar seus personagens de forma randomizada: todos seus poderes, talentos, origem e atributos vão ser gerados randomicamente. SPOILER: só tem personagem MERDA!!! Social … The post Podcast MdM #434: Os MdMs jogam o RPG da MARVEL dos anos 80! appeared first on Melhores do Mundo.
No podcast de hoje Hell, Maximus, Change, Nerd Reverso, Poderoso Porco, Nasic, Fiorito e Dudu Sales decidem fazer um joguinho respondendo perguntas sobre HQs, como “Qual é sua HQ preferida, seu primeiro gibi, seu personagem preferido, sua vergonha alheia de gibi” e por aí vai… Em um podcast 100% de HQ! Social The post Podcast MdM #430: a listinha das HQs dos MdMs! appeared first on Melhores do Mundo.
No podcast de hoje Hell, Maximus, Change, Nerd Reverso, Poderoso Porco, Nasic, Fiorito e Dudu Sales decidem fazer um joguinho respondendo perguntas sobre HQs, como “Qual é sua HQ preferida, seu primeiro gibi, seu personagem preferido, sua vergonha alheia de gibi” e por aí vai… Em um podcast 100% de HQ! Social The post Podcast MdM #430: a listinha das HQs dos MdMs! appeared first on Melhores do Mundo.
Salve nerdaiada maldita… No pod de hoje os intrépidos MdMs Hell, Change, Nerd Reverso, Lojinha, Catena, Algures e Maximus recebem os MdMs honorários Adriana Melo, Marcio Fiorito e Fernando Caruso para falarmos sobre HQs, filmes, séries e jogos que vimos recentemente e NÃO INDICAMOS pra vocês, em mais de 4 horas de muita cagação de … The post Podcast MdM #421 DESindicações! O que nós lemos, jogamos e assistimos e NÃO RECOMENDAMOS pra vocês! appeared first on Melhores do Mundo.
Salve nerdaiada maldita… No pod de hoje os intrépidos MdMs Hell, Change, Nerd Reverso, Lojinha, Catena, Algures e Maximus recebem os MdMs honorários Adriana Melo, Marcio Fiorito e Fernando Caruso para falarmos sobre HQs, filmes, séries e jogos que vimos recentemente e NÃO INDICAMOS pra vocês, em mais de 4 horas de muita cagação de … The post Podcast MdM #421 DESindicações! O que nós lemos, jogamos e assistimos e NÃO RECOMENDAMOS pra vocês! appeared first on Melhores do Mundo.
Hell, Lojinha, Maximus, Leo Finocchi, Triplo e Change recebem os MdMs honorários Daniel HDR e Fernando Caruso pra falar daqueles personagens bostas que só nós gostamos!!! Social The post Podcast MdM #412: Os personagens merdas que nós gostamos! appeared first on Melhores do Mundo.
Hell, Lojinha, Maximus, Leo Finocchi, Triplo e Change recebem os MdMs honorários Daniel HDR e Fernando Caruso pra falar daqueles personagens bostas que só nós gostamos!!! Social The post Podcast MdM #412: Os personagens merdas que nós gostamos! appeared first on Melhores do Mundo.
No bate-papo MdM de hoje, Hell, Máximus e Lojinha recebem Adriana Melo, Marcio Fiorito, Leo Finocchi, Camilo Solano para falar sobre o destino do FIQ, e como você pode ajudar. Entre aqui nesse link e peçam a volta do FIQ para a prefeitura de BH! Seria no FIQ que TODOS os MdMs se reuniriam pela … The post Bate-papo MdM: o destino do FIQ e como ajudar! appeared first on Melhores do Mundo.
No bate-papo MdM de hoje, Hell, Máximus e Lojinha recebem Adriana Melo, Marcio Fiorito, Leo Finocchi, Camilo Solano para falar sobre o destino do FIQ, e como você pode ajudar. Entre aqui nesse link e peçam a volta do FIQ para a prefeitura de BH! Seria no FIQ que TODOS os MdMs se reuniriam pela … The post Bate-papo MdM: o destino do FIQ e como ajudar! appeared first on Melhores do Mundo.
No podcast de hoje Hell, Nerd Reverso, Lojinha (e depois Change e Anderláine) recebem os MdMs honorários Dudu Sales e Adriana Melo para falarem sobre todos os indicados ao Oscar de melhor filme! Social Comentados nesse Podcast: Catarse Wander & Angúria Cirurgia do Siddartha Workshop com Rodney Buchemi no Dínamo Estúdio: Veja aqui no Youtube: … The post Podcast MdM #404: os indicados ao Oscar 2017 e a MELANCOLIA GOSTOSA appeared first on Melhores do Mundo.
No podcast de hoje Hell, Nerd Reverso, Lojinha (e depois Change e Anderláine) recebem os MdMs honorários Dudu Sales e Adriana Melo para falarem sobre todos os indicados ao Oscar de melhor filme! Social Comentados nesse Podcast: Catarse Wander & Angúria Cirurgia do Siddartha Workshop com Rodney Buchemi no Dínamo Estúdio: Veja aqui no Youtube: … The post Podcast MdM #404: os indicados ao Oscar 2017 e a MELANCOLIA GOSTOSA appeared first on Melhores do Mundo.
Nessa semana os MdMs falam o que acharam de Rogue One. Tem um monte de gente aí que eu não me lembro foda-se é natal escrevi isso e saí correndo pau no cu de quem tá lendo. Social The post Podcast MdM #396: As Aventuras de Rogue One e o Han Solo Genérico appeared first on Melhores do Mundo.
Nessa semana os MdMs falam o que acharam de Rogue One. Tem um monte de gente aí que eu não me lembro foda-se é natal escrevi isso e saí correndo pau no cu de quem tá lendo. Social The post Podcast MdM #396: As Aventuras de Rogue One e o Han Solo Genérico appeared first on Melhores do Mundo.
Salve nerdaiada amaldiçoada… No bate papo de hoje os únicos Mdms que ainda assistem as séries do CW, Hell, Ultra, Algures e Nasic conversam sobre a iniciativa de se produzir um megacrossover entre todas as séries superheroizísticas dos heróis da DC (Supergirl, Flash, Arrow e Legends of Tomorrow) adaptando a saga das HQs, Invasão, para … The post Bate-Papo MdM: Crossover séries do CW – Invasão appeared first on Melhores do Mundo.
Salve nerdaiada amaldiçoada… No bate papo de hoje os únicos Mdms que ainda assistem as séries do CW, Hell, Ultra, Algures e Nasic conversam sobre a iniciativa de se produzir um megacrossover entre todas as séries superheroizísticas dos heróis da DC (Supergirl, Flash, Arrow e Legends of Tomorrow) adaptando a saga das HQs, Invasão, para … The post Bate-Papo MdM: Crossover séries do CW – Invasão appeared first on Melhores do Mundo.
No podcast dessa semana temos Change, Hell, Rodney Buchemi, Catena, Poderoso Porco, Máximus, Triplo, Lojinha e Nerd Reverso falam sobre as músicas que mais escutaram em sua vida. É cada vergonha alheia que vou te dizer, heim… Social Comentados no podcast: – Playlist do Rodney Buchemi – Playlist do Nerd Reverso – Playlist do Change … The post Podcast MdM #382: As playlists dos MdMs e suas vergonhas musicais appeared first on Melhores do Mundo.
No podcast de hoje Hell, Change, Ultra, Nerd Reverso, Triplo e Lojinha comentam todo o processo do Impeachment… Em um papo que começou animado, mas depois foi miando por causa do tom desanimador de todo o processo, os MdMs mostram o que concluíram e aprenderam com todos os podcasts badernistas desde 2013. Social Comentados no … The post Podcast MdM #380: o podcast derrotista conformista badernista sobre o Impeachment appeared first on Melhores do Mundo.
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 03/07
In this study the ability of different Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) strains to survive in bovine monocyte-derived macrophages (MDMs) was investigated. The following hypotheses were tested: 1) Infection status of a cow does not affect the ability of its macrophages to kill M. paratuberculosis 2) Killing capacity of bovine macrophages is not dependent on the M. paratuberculosis strain MDMs for conducted experiments were obtained from Johne’s disease-positive (n = 3) and age and stage of lactation matched Johne’s disease-negative (n = 3) multiparious cows. Animals were kept on the same dairy operation, thus non-infected cows had been exposed to M. paratuberculosis strains present on the farm premises. Peripheral blood mononuclear cells (PBMC) were isolated from whole blood by density gradient centrifugation. After a five-day differentiation period in cell culture using Teflon jars MDMs were obtained and subsequently challenged in vitro with four M. paratuberculosis strains of different host specificity (bovine, ovine). MDMs were harvested at 2 hours, 2 days, 4 days and 7 days following infection. For each time point ingestion and intracellular survival of M. paratuberculosis strains were determined by fluorescence microscopy. There was no effect of the origin of MDMs (Johne’s disease-positive or control animals) on phagocytosis, survival of bacteria, or macrophage survival. In contrast, important strain differences were observed. These findings suggest that some M. paratuberculosis strains interfere more successfully than others with the ability of macrophages to kill intracellular pathogens which may make it important to include strain typing when designing control programs.
© 2020-2025 Ivy Podcast Discovery LLC
