Podcasts about osteogenic

Osteogenic loading is an evidence-based approach to building bone strength without medication.

Show notes: (7:03) Epigenetics and DNA (14:21) Influencing genetics and creating autonomic anchors (22:53) Health benefits of breath holding and foot scraping (30:21) The value of eye convergence (34:34) Achieving acidosis through elevation training  (39:50) Osteogenic loading as a longevity solution (48:09) Outro Who is Tony Molina? Tony stands among the most accomplished thought leaders in the contemporary biotuning movement. His experience across multiple modalities for performance, fitness and healthspan puts him at the forefront of his class.   An Amphibious Reconnaissance Marine Team Leader in the first Gulf War during Operation Desert Storm, he rose as a U.S. Navy Diver and Navy Seal Obstacle Course record holder. Tony raced for 10 years on the elite professional expedition racing circuit producing life altering achievements during nonstop, 24 hours a day, grueling 300-to-500-mile courses in Mark Burnett's Global Eco Challenge Expedition Competitions and the Infamous Raid Gauloises held in remote locations such as the jungles of  Malaysia, the high Atlas Mountains of Morocco, the steppes of Patagonia Argentina and on the glaciers and rivers of the South Island of New Zealand.    Tony has helped thousands of people navigate the longevity space including Lykke Li, Peter Guber, Roma Downey and Mark Burnett and was a two-time presenter at the Tony Robbins Platinum Partnership.  Tony founded the Arête Lifelab, the future of longevity biohacking and is the Senior Research and Development Specialist at Powerplate currently developing their newest product coined “The Ultimate Exercise Biohack”.    Annually, Tony conducts high altitude research on the Matterhorn, the Everest Region, Volcano Alley in South America and across the slopes of Kilimanjaro, discovering the rate limiting steps in human performance and how humans can address the diseases of our civilization. Connect with Tony Molina: Website: https://aretelifelab.com/ TikTok: https://www.tiktok.com/@aretelifelab LinkedIn: https://www.linkedin.com/in/tony-molina-74504353 Youtube: https://www.youtube.com/channel/UC2aXW_a5aDzbrFgUJqpg1-A Links and Resources: Peak Performance Life Peak Performance on Facebook Peak Performance on Instagram  

Suffering from osteoporosis, osteopenia, or another bone disease that is making your life miserable? Check out OsteoStrong Colorado Springs' natural remedy for musculoskeletal disorders! Call them at 719-362-5331 or visit https://centers.osteostrong.me/colorado-colorado-springs/ today! OsteoStrong Colorado Springs 5992 Stetson Hills Blvd, Colorado Springs, CO 80923, United States Website https://centers.osteostrong.me/colorado-colorado-springs/ Phone +1-719-362-5331 Email stetsonhills@OsteoStrong.me

(3:00) - 3D printing with bacteria-loaded ink produces bone-like compositesThis episode was brought to you by Mouser, our favorite place to get electronics parts for any project, whether it be a hobby at home or a prototype for work. Click HERE to learn about how additive manufacturing is being leveraged in the medical industry from bone replacement to dental guides!

OsteoStrong uses a revolutionary treatment protocol called osteogenic loading. Targeting specific kinetic chains in the body, these treatments safely load sufficient amounts of weight to trigger an adaptive response in the body resulting in osteogenesis. You can find out more about Osteogenic Loading https://osteostrong.me/ Follow on Social Media at https://www.facebook.com/osteostrongsyracuse https://www.instagram.com/osteostrongsyracuse/

Thank you for joining us for another episode of the Low Carb MD Podcast. Dr. John Jaquish began his experience in life sciences after being told by his Mother that she had been diagnosed with osteoporosis. John, in an effort to help his mother, created a device to place axial loading through bone to safely cause osteogenic loading events. After successfully reversing his Mother's osteoporosis, as part of his doctoral dissertation in biomedical engineering research at Rushmore University, he conducted four years of testing with human subjects focused on user comfort, biomechanics, and optimal musculoskeletal stimulation. Next, the device he designed was put into production, and has since been placed in over 300 clinics worldwide. Osteogenic loading has now helped over 30,000 individuals with their bone health. Dr. Jaquish is currently advancing osteogenic loading research and speaking worldwide about its implications, as well as developing other biotechnology devices and products that will aid in the advanced health and wellbeing of people all around the world. He formerly a member of the Board of Directors of American Bone Health, and the editorial board of the Journal of Steroids and Hormonal Science. In this conversation, Drs. Tro, Brian, and John talk about how John got into the biomedical field, leadership and interest issues in the American Medical Association, the damage of corruption and lack-of-integrity, the peculiar case in many Western countries of the poorest people being the fattest, why cardio is actually not conducive to weight-loss, over-eating and environmental factors relating to metabolic disease, why Dr. John switched to bands in lieu of weights, why variable resistance is better than weight training, and keeping a critically thinking mind when you take in exercise and nutrition marketing. For more information, please see the links below. Thank you for listening!   Links:   Dr. John Jaquish: Jaquish Biomedical Instagram Personal Website YouTube Weight Lifting is a Waste of Time   Dr. Brian Lenzkes:  Website Twitter   Dr. Tro Kalayjian:  Website Twitter Instagram

My guest began his experience in life sciences after being told by his mother that she had been diagnosed with osteoporosis. John, to help his mother, created a device to place axial loading through bone to safely cause osteogenic loading events. The device was to trigger the effects of high-impact loading, but without the risk of injury.After successfully reversing his mother's osteoporosis, as part of his doctoral dissertation in biomedical engineering research at Rushmore University, he conducted four years of testing with human subjects focused on user comfort, biomechanics, and optimal musculoskeletal stimulation. Next, the device he designed was put into production, and has since been placed in over 300 clinics worldwide. Osteogenic loading has now helped over 30,000 individuals with their bone health. Published data has shown, treatment with this osteogenic loading device has resulted in over 14% gains in bone density in both the spine and hip over one year of once-weekly treatment. www.jaquishbiomedical.comhttp://www.yourlotandparcel.org

In a preliminary study of the Stability of the mandibular dental arch following periodontally accelerated osteogenic orthodontics therapy (PAOO), it concluded that PAOO therapy resulted in significantly greater improvements during the orthodontic retention period, as judged using the ABO-Objective Grading System on study casts and panoramic radiographs. The study scored for 8 criteria  immediately after orthodontic treatment and at least 1 year of retention.Measuring ResultsThe ABO Objective Grading System for scoring dental casts and panoramic radiographs contains eight criteria: • alignment• marginal ridges• buccolingual inclination or the the angle between the long axis of lower second molars and a reference line tangent to the lower border of the mandibular body• occlusal relationships and contacts related to the grinding or biting surface of a tooth• overjet, or when the upper front teeth protrude outward• interproximal contacts, or the space that lies between teeth that is occupied by the gum, and•root angulation, or the portion of the tooth that is buried in the tissues.PAOO FindingsIn the study, non-extraction orthodontic patients were treated to resolve crowding with PAOO and without PAOO during an average of 19.6 and 16.4 months, respectively.Moreover, the amount of relapse following treatment was significantly greater in both control subgroups compared to both periodontally accelerated osteogenic orthodontics subgroups.A Mann–Whitney U test (used to compare whether there is a difference in the dependent variable for two independent groups) showed that the two groups were statistically homogeneous at post-treatment but at retention, the PAOO group was significantly better for alignment. Moreover, the Objective Grading System total score dropped precipitously (or improved) during retention in the PAOO group compared to the control group. Preliminary retrospective university research indicates that the mandibular dental arch is more stable after PAOO therapy in comparison to traditional orthodontics.It is surmised that the remarkable stability following PAOO is due to substantial “memory” loss of periodontal tissues and increased cortical bone thickness due to alveolar augmentation grafting.About Periodontally accelerated osteogenic orthodonticsPeriodontally accelerated osteogenic orthodontics is a relatively new procedure designed to minimize the time taken for orthodontic treatment. The orthodontist avails of the aid of a periodontist to perform decortication of the bone and places bone graft for rapid orthodontic correction of malocclusion.To discover the latest innovations in orthodontic treatments that reduce treatment times and produce long-lasting, airway-beneficial and aesthetically-superior results schedule a consultation at Airway and Sleep Group.

Speaker1: [00:00:00] Hello, my beautiful people, you know, it is Humpday because I am here talking to you and you know that I released these episodes on Wednesday, so excited to be here. And we have another amazing guest because, you know, I read nothing but quality. And his name is Dr. John Jaquish. He is a Wall Street Journal best selling author and an inventor of the most effective bone density building medical device, which has reversed osteoporosis for thousands and created more powerful and fractured resistant athletes. His devices were put into production and has since been placed in over 300 clinics worldwide. Osteogenic loading has now helped over 20000 individuals with their bone health. Dr. Jaquish also quantified the variance between the power capacities from weak to strong wages and weight lifting, which brought him to his second innovation x3. The research indicates that this products build muscle much faster than conventional lifting and does so in less training time, all with the lowest risk of joint injury. Dr. Jaquish is a research professor at Rushmore University, speaks at scientific conferences all over the world, has been featured on many of the top health podcasts, is an editor of multiple medical journals and is a nominee for the National Medal of Science. I am so excited to have him on here because we're going to have some controversial topics that we're going to be discussing, including why not weightlifting and the whole fitness trend and so many more things. Welcome, Dr. Jaquish, a.k.a. Dr. J. How are you today?   Speaker2: [00:01:48] I'm super. Thanks for having me, Elizabeth.   Speaker1: [00:01:51] I mean, thank you for being here. I mean, you know, I'm going to put you on the spot on the podcast. I don't normally do this, but I think I'm inspired by you as being my guest to have a little section called Rumor Has It. And so be prepared.   Speaker2: [00:02:07] I will. There's all kinds of crazy rumors going around about me. Most of them are just ludicrous. But I always I enjoy even the ludicrous ones that are very comical.   Speaker1: [00:02:16] Ok, so we're going to we're going to sneak them in there if you let me. So thank you. So I want to start talking about first of all, let's talk about your product. Right. Let's let's talk about what made you disrupt the fitness world. And do you feel like your research and technology and your competitors who use your traditional way of getting lean and building muscle?   Speaker2: [00:02:42] Ok, yes, it's definitely a threat to the old way of getting fit. But let's face it, the old way of getting fit didn't really work for many people. Like, really think about it. The people who, you know, go to a gym three or four times a week and have been doing so for years. Do they look any different? Right, silence, they don't. Yeah, yeah, and in fact, there's there's data on the top leanest one percentile of males in the nation. It's ten point nine percent body fat, basically 11 percent body fat. That's the best one percent. Now, percentage body fat is a wonderful number because it considers muscularity also. So because the more muscular you become, the lower your percentage of body fat will be, so. You have a relatively pathetic number as the top percentile. Like, I really shows you, there's not a lot of fat people out there and there's a reason why it's so coveted, people want to be fit so badly because hardly anyone is. And like, why are we trusting an industry that might have a ninety nine point nine percent failure rate? Wow. Like who really who really is fit looking? Who really has completely visible abdominals and muscularity at the same time, you know, is it one in ten thousand people, maybe one in fifty thousand people? It's just uncommon.   Speaker2: [00:04:18] And so when that is how we define fitness, that's how we define and an admirable physique and we look at the statue from eight hundred years ago of Hercules, that's that's in I'm thinking of a particular one. There are a lot of statues of Hercules, particular kind of famous. He's leaning on like a like a tree branch and he's hung a lion skin over the tree branch. But a hundred years ago, you know, the guy looked absolutely incredible. They didn't even have performance enhancing drugs back then. But it's just so rare as my point that somebody had to sit for that statue to be created. Like there was a guy that looked like that eight hundred years ago. But my point is, it's just so rare and now there's a couple of genetic reasons which can be bypassed and I discussed that in my book, Weightlifting is a waste of time.   Speaker1: [00:05:09] Oh, I need that. I need to get that book because and we're going to get into that book, you know, I don't know. I want to get a signed copy. I'm waiting for the signed copy from conservatives. I get from and then rumor has it, but I'll bring that up. But I'm like excited to get my signed copy. But I want to go back a little bit to this technology that you spoke about. You talk about Hercules, right. Like let's pretend right. Like back in the days, we all know Hercules is known for being super buff and strong and like like you said, no, you know, performance enhancing drugs or medications or supplements, whatever you want to call   Speaker2: [00:05:46] Somebody that's got you, you listen to me talk and don't understand what that means. Somebody had to sit there and sit still while the sculptor created the sculpture.   Speaker1: [00:05:58] Yeah, that's a   Speaker2: [00:05:59] A who look like that. They don't just invent muscles out of their mind. No, because they don't know the anatomy. There's very few anatomy classes eight hundred years ago, but people could sit for a statue, so there had to be a guy like that.   Speaker1: [00:06:13] Yeah. And so I want to kind of touch on nutrition a little bit talking about that and you and your book. Right. Like what are your thoughts on nutrition? Because you said ninety nine point nine percent of the population are not succeeding in that. And so, you know, when you were asking me a question about you said, you know, who do you know that's really fit and who's going to the gym all the time? And I'm thinking, yeah, they're going to the gym all the time. But they're also like meticulously counting their calories, their macros, their protein.   Speaker2: [00:06:46] They still don't look any different, do they?   Speaker1: [00:06:48] Not by that much. So let's talk about that. I want to hear your thoughts on these fad diets, these new diets that we know that Hercules was definitely not doing.   Speaker2: [00:07:00] Primarily what I eat is red meat. Now, I also it's all about the quality protein when it comes to building muscle. Now, the two greatest drivers of long life or high levels of muscularity and low levels of body fat. So those are the two things I'm kind of best at. Having a low level of body fat and a high level of muscularity now, how does that happen? The easiest well, you have to have a lot of dietary protein and it has to be of quality. So, like, vegetable protein is only nine percent and that's like nine to four percent usable by the body. So you can you can have. Whatever, one hundred grams, but it really only counts like nine grams, so that would be like a pound and a half of broccoli will give you nine grams of use, but you need one gram per pound of body weight. Not a lot of people weigh nine pounds, so especially adults. So you can't have vegetable sauces and get anywhere. In fact, you're losing Moscow muscle the whole time. You're like vegan or vegetarian. So that's why there's weight loss also. Yeah, the losing body fat is a record deficit, but they're also losing muscle very rapidly. And that contributes to a lot of chronic conditions and early death. So, you know, does it do some good things for you going vegan or vegetarian? Yeah. Yeah, it does. It cuts a lot of processed food out, and that's good. But you can cut processed food out and still have animal protein or diet. So, yeah, that's that's primarily where I am. I did create a product that wasn't specifically for vegans, it was for everybody, but a lot of people.   Speaker2: [00:08:49] And they found a one gram per pound of body weight like I weighed 240 pounds. So 240 grams of protein is like two and a half pounds of steak. And I eat one meal a day because I want to fast and benefit also. So when you sit down for one meal and try and eat two and a half pounds of steak that lasts like half a pound, you don't love it. Wow, it's like work, is it, and you don't feel good afterward, you know, so your girlfriend wants to cuddle with you and you're like, now I'm going to have any Digest's. Let me just lay here. And so that just wasn't it wasn't great. So I worked with a with a group who had engineered a cancer treatment. That that was a very. Usable, essential amino acid product and most essential amino acid products are about as usable by the body as sand. Unfortunately, yeah, there may be the amino acids and everything weren't created correctly. They weren't created with fermentation. Basically, we're supposed to eat rotting stuff. And obviously, for sanitation reasons, we don't, right? So what what this is, is gives us the benefits of that rotting material fermentation without the taste and it's clean and there's nothing that will give you an infection or anything. Yeah. And so it's called Vortigern. So so I take about two two hundred grams of protein and protein value. Wow. I mean, I literally have to eat like a half pound steak and I'm good,   Speaker1: [00:10:29] And now you can cuddle with your girlfriend.   Speaker2: [00:10:32] Yes, very   Speaker1: [00:10:33] Good. So everyone everyone wins here.   Speaker2: [00:10:36] Everyone wins. Yeah, exactly. Bet my girlfriend   Speaker1: [00:10:39] Did. She's so sweet. No, no, no. So, yeah, for those guys don't know like I do know his girlfriend. She's so sweet. I did meet her try. We're trying to get her on here but she's doing other activities right now. Working. But she is the sweetest person I've met so far, so I love her. She's amazing. Hi, Jessa waving to her. So when she sees this, we're thinking about her. So let's let's call it let's take it down a notch. So. So you don't recommend. So when people talk about becoming vegan or vegetarian or raw. Right. Like they not only do it because of the benefits of maybe losing weight or taking out those processed foods, but also the impact on the environment. Right. And like all these foreign foods, because not all protein is made equal. Right. Let's let's be honest about that. Right. Like a grass fed grass finished cow beef is not the same as a industrial commercialized, you know, cornfed, right. Exactly. Cow who is fed with hormones and antibiotics and you name it. So let's talk about that a little bit. I would love for you to shed some light on what your intake is on the people who are concerned with carbon footprint and saving   Speaker2: [00:11:53] Animals, the carbon footprint idea or the methane. That's so there were twice as many bison in the United States before Europeans migrated here than there are cow. So where was all the methane and global warming back then? Now, is methane created from grass? Yeah, and if the grass died just seasonally and then came back the next spring, rotting material, dead plants leaves a hole in the ground from trees that creates methane to. Like the same amount, so whether the cow is eating it or just sits there, it's methane equals methane, it's the same thing. So a lot of this is just a gross misunderstanding of what methane is. Also manmade methane number one cause is the medical industry. Like, I think that's like 80 or something, percent of the methane created in the Western world is created by making pharmaceuticals. So I think it's maybe like one or two percent come from cows. So first of all, the greenhouse gases are natural, they come out of volcanoes, they come out of plants, uh, the kind of rotting material, we're not gonna do anything about that. Like, unless you want to cut down every tree, then we'll die, we're all die for another reason. So every animal that saving the planet, then selling it back. So there's no sustainability argument was. A false narrative created by Vegan's and Seventh Day Adventists by Seventh Day Adventists, that's part of the religious mandate that they convert everybody to being vegan, hereditary.   Speaker2: [00:13:35] And so, yeah, they're doing their religious work. So, I mean, I guess I guess good for them until they start lying in the press about things like this. And then, you know, that just becomes annoying. And also then these kind of issues get brought up in Congress and then people are voting on taxes, on food and. Different things they don't understand, like people in Congress have no understanding yet, they want to jump in the middle of it because it's political, because people care. So it's funny situation, pretty alarming. And also there's political correctness. So we want to be nice to animals. Now, here's a statistic. Seven billion animals are destroyed every year for the sake of vegetable farming. So you're actually growing vegetables kills just as many or more animals as eating animals. And the reason is how many gophers do you need to kill him out of your field? Poisoned by the thousands of birds, poisoned by the thousands, and then, of course, other animals eat dead birds and then they die to. And then, dear, if a deer gets in a vineyard like I, I went to high school in the Napa Valley, I watched deer jump in the vineyards immediately get shot. You can't get it. You can't get a deer to walk out the front gate. There's dumbest cockroaches. They won't ever understand that. You just shoot them. And so they did. I saw a deer shot all the time.   Speaker1: [00:15:11] Yeah, I do know that's a bummer.   Speaker2: [00:15:14] Like, wow. Yeah, I guess the deer just went the wrong place. They should have gone somewhere else to eat, but, um. Yeah, that's just that's just part of it. But also from a broader perspective and this is what everybody should keep in mind, any species that's growing is taking resources away from another species. So this isn't just true of humans. If more snakes show up, they eat more mice. They eat so many mice that. There's lower and lower population of mice in a given area, so they're taking resources because they're expanding population, that is a way of balancing itself out later on. But as long as we have an expanding population, we're going to take resources from something. No, no way around it. And so, I mean, the joke is you really want to help the planet just kill yourself. Oh my gosh. Yeah, I mean, it's obviously a bad joke with science like this. Like, we're people. We take up resources. There's no way that we're not going to take up resources no matter what we do. So it's an acre garden that we have to kill all kinds of animals to stay out over eating the food we intend to eat. What are we really doing? Anything.   Speaker1: [00:16:31] Right. Right. And I also want all the animals. Yeah, no. And I want it. Exactly. I wanted to clarify, like I know you said earlier about the deer to shoot him. And I wanted to just clarify for reference that if you like, read your state laws and you see that, you know, farmers like a peach or orchard could potentially is allowed to, by law, kill a squirrel or anything that comes to eat the they are allowed to. And like this is the kind of stuff that we don't talk about, like the almond farms, the peach farms, the apple farms, all the vegetable farms they are allowed to. And they do kill every single thing that comes in there from the Buber's from the moles to the foxes to the ducks, to the birds, to the squirrels. And and they are allowed to because I, I randomly like I went to a friend's house in Jersey and the guy was just shooting squirrels, unfortunately. And we were like, what can we do about this? And we called and we and the local police officer, you know, whatever he said that he has an apple tree and he has every right to defend the fruits from his property. And if that meant Menta to do that, he was able to. And I was just so shocked. I'm like, it's not enough. It's not a real farm. But technically, he's protected and they were protecting him. So I do want to bring that up. When you when you said that, it's not like, yeah, shoot the deer. That's not what you meant. You meant like that to their right. And that's what they do. Yeah. We're just going   Speaker2: [00:18:00] To talk about the losers in. You're right to do everything to keep the grapes from ever shown up the bite off every leaf. Wild boar are typically shot from helicopters because they come near farms and tear up the ground. So, yeah, just   Speaker1: [00:18:19] Just the other side,   Speaker2: [00:18:20] Weapons from a helicopter using very selected narrative that the press likes to hang on to, it's like saving animals is good and very simplified, like like people seem to want all of their health and lifestyle advice boiled down to like a mean like a half a sentence. Yeah. And like, these issues are just not so simple. It's not like vegetable good, meat bad, right? You know, you you eat that way, you'll die of malnutrition. You get no vitamin B 12, which is absolutely essential for life. So, you know, like you can do that.   Speaker1: [00:19:03] Hey, Dad, I have a story, actually. I mean, I didn't die, but I was really sick for a long time and I didn't know what was wrong with me. Doctors didn't know what was wrong with me. I was under every experimental medication you can probably think of. It was like Celiac, Crohn's, IBS. And there was like, could it be like my grandmother had pancreatic cancer and she had survived that. She went to Peru, she killed herself. They gave her a six to eight months to live. And I think it's already maybe 15 years. And she's still here kicking and screaming. So they thought maybe this is what it looks like, the precursor because they precursor cells, they didn't know what was wrong with me. So they put me on these diets first. It was vegan because they were trying to rule things out. And then this is by my doctor, right. Vegan. And then I became vegetarian first. Then it went to vegan and then it became Rovi again. And because it was such a big shift in my body, I had a massive gallbladder attack and my gallbladder was removed, not because it had stones, not because I was unhealthy, but because it was such a shock for my system. So today I do eat animal protein, but I'm mindful of the protein that I eat. I don't eat a lot of it because it's so hard to process the protein without a gallbladder. That's just the reality of it. But I was told by the doctor afterwards that a lot of times people go into these diets so quickly that their body does go into shock and it can cause different organs to fail. And I'm not trying to I hate like I don't like to make people fearful. I'm a big advocate for having root vegetables. I love I happen to love vegetables.   Speaker2: [00:20:47] That's just   Speaker1: [00:20:48] It's. Yeah, I'm just sharing like what my experience. So I just wanted to share that on, you know, diet and like what your opinion was on that.   Speaker2: [00:20:57] I guess a lot of me. No, I don't go to vegans and complain that they should stop being like, you know, I, I in fact, I created a product where they can actually get high quality protein and continue to be vegan. So the bacterial fermentation product. It's there's no meat involved in the creation of that, so it's vegan friendly, amazing. So yeah. Yeah. So I'd rather help them, but. At all, I'm going to be honest, scientifically, it's just there's no case for it, it's it's a bad idea and that ultimately lead to just a poor outcome. But it takes people a lot of years before a lot of these symptoms catch up with them, like the teeth falling out because you have no V12 like I've seen vegan's where you bite into something and the truth will come out like I'm talking like people in their 20s because they've been vegan for ten years. So the really bad symptoms start after seven years because initially a lot of people went and tried this and they're on a caloric deficit and they lost a bunch of body fat because you can't eat enough vegetables to even cover, like what your body needs from basic perspectives. So you drop a bunch of weight and people think thin is healthy. I mean, lean is healthy, thin is maybe a little bit healthier, depending on where you're coming from, but, you know, that also might be dying. So let's keep that in mind, yeah, because there's a lot of dysfunction, so cut weight like cancer make you lose weight, that doesn't mean it's a good thing. Another thing. Like like the vegan research is typically paid for by Nabisco, Kraft packaged food companies they call big foods a big food industry, and then they would love for everybody to be a vegan because they know vegans aren't eating kale. Most of the time they're eating cookies and cake because it's convenient if it's like it's not it's not a meat product. Right.   Speaker1: [00:23:05] I mean, to be fair, there are different kinds of vegans, right? Like there's like the junky vegans who eat, like all the, um, I don't want to just junk food that, you know, just as vegan. And then there are the ones that are more conscious about the kind of food. Is it from a biodynamic farm? How is it raised? Like how is it grown? Is it like coming from a is the soil biodiversity and all this stuff? So like, I just want to put that out there. I'm not bashing and neither is Dr. J. We're not bashing anyone, just kind of talking about these kinds of things. But Dr. J. I want to I thought this is a great Segway talking about gains, right. Like muscle gains and talking about body fat. Can you explain how using your technology helps to gain more in your goal without impacting your body and like low impact and how it doesn't cause any joint issues,   Speaker2: [00:23:58] So it lets you train heavier? That's the easiest way to explain it. Like you train heavier than you would in a gym. But it's also safer because when it comes to that point where the joint is exposed to potential injury, you get an offload moment where the weight goes way down when the joint is at risk and the weight goes way up when the muscle is fully engaged. So you go to a much deeper level of fatigue, weight training with a heavier weight. And everybody that knows anything about strength training, however you go, the more you grow. So really straightforward uses very heavy latex resistance, but there's also an Olympic bar to protect your wrists that's right here. You can see as I rotate the bar, this always stays parallel with the ground, and that's to keep your wrists neutral and keep your small bones in the wrists from being broken. And we have an equivalent platform we stand on that is to protect the small bones in the ankles as people who just do band training, all they're doing is injuring the wrists and ankles. Oh yeah. Because or they're training so light. It's doing nothing.   Speaker1: [00:25:08] Wow. OK, and what was the process of creating these products, how did you crack this code? Like please share with us the back story?   Speaker2: [00:25:17] I'm not really part of the fitness industry. I never was like I mean, the fact that I sell something that has talking points that are fitness, I see the fitness industry is just a complete failure. No joke. Ignoring science for 50 years, just like everything like like the idea the cardio helps you lose weight. No. Doesn't. Does the opposite, it protects your body fat and gets rid of muscle, so it gives you the opposite. We think. So know, I see people like on treadmills and, you know, just wasting their time getting worse. Wow. I come from the medical device industry. I developed a medical device to reverse osteoporosis a little over 10 years ago. And that's been outrageously successful when I looked at bone and how to figure out how to treat bone and make it grow very rapidly after I figured that out and produce a product launch that prior to the clinical trials of that product, I realized I had gathered data on loading of the body that would completely negate the existing fitness industry or strength strength training industry. Now. If you look at what's the difference between cardio equipment and strength, equipment, cardio, what we call cardio is just really shitty strength training. That doesn't work, doesn't make it stronger, your body doesn't know the difference between a treadmill and a squat rack like you're contracting your lower extremities muscles, your long johns. But he knows the difference in how heavy you're going. Because that's what fatigues the muscle.   Speaker2: [00:26:57] So all you're now, you're fatiguing your cardiovascular system during either. And it just so happens that there's more than one hundred studies that show that fatigue in your cardiovascular system with weights. Will give you as much cardiovascular benefit or more then cardiovascular training, so cardiovascular training, as we call it, like I said, there's really no such thing. You don't get any stronger. You actually get weaker because it regulates cortisol and cortisol cannibalizes muscle. You protect your body fat. So you stay fatter longer and you don't get as good of an effect or an equal effect to strength training. So why don't you just do strength training? Well, like I said, the answer is so obvious now, if you're training to be a marathon runner, you got no choice. You have to run marathons. But a marathon runner, their biochemistry by secreting cortisol is trying to get rid of muscle as fast as possible. So they're losing muscle. And this is like this mythical idea that you can be a, quote, well-rounded athlete and have cardiovascular endurance by doing endurance training. And be very muscular. Now, those are two conflicting goals, you're not going to get a Formula One car to have 40 miles to the gallon like they're conflicting goals, conserving fuel and going fast, conflicting goals. So so now I have great cardiovascular endurance, I can do a lot of work in a short period of time. But because of my level of musculature, like I said, I'm six foot six feet tall, about seven percent body fat and.   Speaker2: [00:28:46] Two hundred forty pounds, so when I sprint up a flight of stairs, maybe two flights of stairs, I'm a little out of breath. But a skinny guy, the way one hundred pounds, one hundred pounds less me. He doesn't he's not out of breath when he sprints up the two flights of stairs to the common. The ignorant comment that many make is all strength athletes have poor cardiovascular endurance. No, they don't, because my legs may be five times the size of his legs. So when my quadriceps are asking my heart for blood, it's a lot more blood that's got a pump in there, that's a far more powerful engine. So in essence, I'm driving a V12 and that guy is driving like a four cylinder. So right wing engine, a weak engine doesn't draw a lot of fuel. And so, you know, just because I'm more powerful and I'm designed to do a lot of work in a short period of time, you know, I try and do work in a long period of time while I don't have the engine for that. Like. Which is why, again, a cardiovascular athlete has very little muscle mass because the biochemistry is forcing them to have very little muscle mass. So this whole, like, endurance thing in cardiovascular health, if your idea is to have a healthy heart through strength training, if you want to run marathons, obviously you got to do a marathon type training for you.   Speaker1: [00:30:14] Guys like that are listening and driving. And, you know, just listening to us talk to an audio, we are also video recording this so you can actually see Dr. J. He doesn't work out, but he's he's at seven, what, seven percent body fat. And he looks   Speaker2: [00:30:28] Like, oh, man, I work out with X.   Speaker1: [00:30:31] Well, let me let me take that back. He's not from the business world. He's not lifting weights. He's not measuring his macros and doing all these kinds of things. He is literally following his formula. So I invite all of you guys to come and see this because I need to go and start doing this kind of training, hopefully soon, or I'll have, like, the arms that we spoke about before with you and your girlfriend. Know, this is very interesting stuff. And, you know, I want to just take it back a little bit. I know that you first started in the space of how to repair or how to grow or you have to help me out with the lingo here for osteoporosis because of your mother, am I correct?   Speaker2: [00:31:13] Yeah. Yeah, I was all inspired by my mother. Yes, she had osteoporosis. I wanted to figure out how to treat it. She was unwilling to take any of the medications because of the side effects. And I don't really blame her. But I said, well, you don't want to take any medications. I might be able to figure this out. Now, I came from a very fresh perspective. This was even before I did my Ph.D.. So I just my experience is more like I just want to learn how to author papers academically because that's a skill like, you know, you don't just like you read a research paper. There's a reason most people can't read them because it's a lot of statistics, a lot of information condensed. I know nobody feels like they're condensed because a lot of times are 20 pages, but that could have been two thousand pages of forms. Yeah, yeah. So, yeah, it's a lot of information condensed in an academic manner and I wanted to really be able to do that. Everyone has had the biochemical approach to a lot of these physical medicine dysfunctions. And I'm like, well, deconditioning of a bone. Is osteoporosis? Well, you can deconditioned it, you can recondition it right right now and everybody kind of look at me like, oh, I suppose I got seems crazy, but there is research there on like it was gymnastics. The gymnastics research really got me that. That was the key moment where I, I found the right research. I looked at the rate at which people were hitting the ground and they hit the ground so hard, sometimes ten times their body weight, incredible muscle density, but bone density as well. So the bone I was I was looking at. So I just thought, OK, like, I'm not going to tell my mother to do gymnastics, you know, in her 70s, but I can build a high impact emulation device. And that's what I did. And that's what's at the osteo strong locations.   Speaker1: [00:33:14] Wow. Amazing. And I wanted everyone to hear because a lot of times we think of like, why would somebody like this what is the goal here? Like, if you're just trying to, you know, like if you can you flex a muscle for us? I hate to make you do this, but like, there's a lot of muscle there, like hardly any body fat. And so, like, you would think that he did this because he just wanted to look good. I'd figure that crack that code. But the story behind where this all started was the love for his mother and to help her. And I'm assuming that she's doing well today. Right?   Speaker2: [00:33:46] Right. Yeah.   Speaker1: [00:33:47] Yeah. So amazing. So this is what you call the love of a son. And it's beautiful because the company has grown. And I want to talk a little bit about some rumors that I heard. I I've seen Tom Brady doing the X three. Yeah. And he shrugging your shoulders, but I've seen it. So, like, you can't you cannot not talk about it. And so.   Speaker2: [00:34:14] Yeah, yeah, I could definitely not talk about that. But I, I Peyton, I know that I will say I just finished filming a video series with Terrell Owens, who is another one of the greatest football players of all time, and also a much stronger guy, Tom Brady. So he's he's an excellent user and he uses it right. Which I find very pleasant. When I see videos, I see videos of people using it wrong. It's like, dammit, OK, it's just another another dipshit. You couldn't take fifteen minutes to watch the instructional videos and they're just making up their own exercises and they're going super fast, which doesn't really do anything. Speed training is OK if you're. A pitcher in baseball, but what we're teaching is not sports specific, it's generalized, it's generalized for muscular size, muscular power and muscular endurance and have also you can profoundly have all three and there's synergistic. So, you know, the sports specific stuff. I leave that to the to the trainers and sports. Like, for example, like the book got an endorsement from the Miami Heat and they actually let me use their brand. And, you know, in describing, you know, who's who's endorsing this book. And they almost never do that now. And so, yeah, they're very protective of the brand, obviously, because they just believe in the technology and they start lifting weights and they use X three. Now, what's all them was? Use X three, four strength, power and muscular endurance. But you still got to do all your other drills. Will there be any conflict between strength training and drills? Maybe a little maybe we'll get a little less growth in certain areas and certain muscles are a little overworked or whatever, but.   Speaker2: [00:36:13] You've got to do your drills because being a basketball player isn't just about being strong, it's about having balance. It's about regaining balance quickly. When somebody bumps into you, it's part of the game. So, yeah, they still do all that and so, um, and so I'm working with Terrell Owens and, uh, six other NFL players, obviously retired. He's a Hall of Famer. Yeah. And these guys, they love X three. I especially care for the NFL, the NBA, too, but mostly for technical reasons. The NBA, because they're so tall, a joint injury is much worse on a tall guy that it isn't a shorter guy because there's more leverage on the joint. They can they will feel more pain through that joint for the rest of their lives. You got be very delicate with a joint tall person when it comes to the NFL. Um, I see, um, the day they signed their NFL contract, they're told you can't get injured or otherwise you can lose your contract. It's kind of a funny contract. They can say we're going to pay you forty million dollars over the next whatever few years. But if you get injured, you only get paid, prorated for whatever you played and then the rest of that money's gone. Wow. Yeah. So it's a contract. Sorta. Sorta. Also, the drug tested like all the time. So everybody knows when they see a fit and a player. OK, you know that guy, he really did it. And like in Dr. Jake, which is helping him. So like I want to listen to that guy so that I really enjoy the because like also like there's some bodybuilders that really enjoy using ecstasy also.   Speaker1: [00:38:01] My question for you is, since I'm going to now be doing videos, I mean, I'm not an NFL player or anything like that. I'm a good person. So I'm going to be doing the X three soon. And is it like will I will I look like, you know, offense? Not that, you know, you're a man, so that's great. But like, I don't want to look like a bodybuilder. So is that going to cause that, like, I want to be like a politesse like Fiddlin must, you know, obviously body fat going down. It's great. But I'm nervous that I'm going to look like a bodybuilding woman, which is great if you like that. But I just don't happen to, you know, like that. Look for myself.   Speaker2: [00:38:41] Yeah. You're not going to look like that. Yeah. I mean, you seen Caroline. She looks incredibly feminine. Yeah. Yeah. So now she modifies the program a little bit. She doesn't do direct arm work. We just want to make our arms any bigger, but she does the postural movements, the lower extremity movements, uh, she does calves, she really likes how her calves look in heels. Now, they kind of didn't look very developed at all before, but they now. But I see. So a lot of people start strength training. And so then they start they have their hungrier because your body wants nutrients. So instead of eating nutrients, they eat Twinkies. So, yeah, I mean, did you get bigger? No, you got fatter, though. So sorry, it's a habit and I see it happen, you know, it's like, you know, you're not going to grow like, you know, 10 pounds of muscle look like a man. Usually that only happens to women who are chemically enhanced like they're injecting drugs. Oh, OK. Get to that to that look. And again, like I like the way you said it. If it's for you, it's for you.   Speaker1: [00:40:01] It's just not for you. So, you know, you guys heard it here. You're going to see me training. And part of the reason why I also wanted to do this was because, you know, Dr. Jay knows that I've had some, you know, not coronations and a lot of pain. And, you know, he said, like, this could potentially help you. So I am excited about this, but I want to talk about another rumor. Can you handle it?   Speaker2: [00:40:28] I can handle.   Speaker1: [00:40:29] Ok, so I heard a little birdie said to me that NASA published the paper, not a birdie, but it's kind of kind of public knowledge.   Speaker2: [00:40:40] It's public knowledge. It's just, you know, it was published in a scientific journal. And there's not that many people in the world that even know how to read those kind of things. But you know what? I will read you a quote from the paper. Let's do it. Yeah, it was a really, really powerful statement they made, but they're truly looking. What I'm doing and changing resistances for different ranges of emotion. As a way to manage the health of astronauts, because without a gravitational field, the body just starts coming apart. Yeah, like like there's two things that are like from it, from a technical standpoint. And obviously, we put a we put an unmanned vehicle on on on Mars already. So the challenge is to get a human to Mars. Will. Little robots with wheels, they do fine with radiation exposure and now exercise. But humans die. So what we need is now the shield from the radiation, like we know how to do that, but what we're going to have to ultimately do is build a spacecraft in space because that kind of shielding is heavy and the most challenging thing for a launch vehicle. Is how much weight, isn't it, the conclusion of the paper says if the exercise apparatus could be condensed to the size of a shoe box to meet the weight and volume restrictions imposed by NASA, it could potentially serve as a countermeasure for bone and strength loss on exploration vehicles.   Speaker2: [00:42:21] Now, exploration, they mean not the moon, right? I mean Mars. So. Yeah, we can we can pull this off and this is exciting. It's a great study and they used bone formation, blood markers, which are highly accurate, unlike the standard for testing bone density, which is a dual x ray. X rays, just a picture of bone and then use software so the picture can determine how dense or porous the bone is. Well, it's a picture analysis. So is it accurate? Not really right now. One of the developers of DEXA had a drink with me at a conference and he said it's like the worst measure in medicine, except it's the best we've got for bond. And in fact, it's considered excluded for analysis. If the same technician didn't run your before and after, you know that that says that there's like an art to lining up the bounding box on the bone, which is what they have to do. They have to look at your hip jobi from a macro perspective and get the box just in the right place. Well one technician doesn't like this, the other doesn't like this. So it's different numbers.   Speaker1: [00:43:37] And so, so if this device may or may not already be in production or whatever, so does this mean that like we can potentially get like maybe like you could do like travel sizes of this. Like I know I'm maybe wishing to fast   Speaker2: [00:43:52] Track says,   Speaker1: [00:43:53] Ok, well, even even smaller, you know. Like how much smaller.   Speaker2: [00:43:57] Well, OK, so like there's what NASA needs and then there's what the rest of us.   Speaker1: [00:44:02] Ok, five.   Speaker2: [00:44:03] True. Yeah. And also keep in mind from a material science perspective, a lot of the forces. That are occurring. Don't need to be engineered in exactly the same way for Earth because there's no gravity. So, you know, that might be different calls for flexibility, there might be. Some portions of latex, portions of nylon, portions of Cavaleiro, portions of, uh, you know, like a like a liquid carbon fiber.   Speaker1: [00:44:39] Are you ready for the last rumor?   Speaker2: [00:44:40] There is a lot of rumors and I'll say it again. So when I first came out with Yoshio's from devices, I was being criticized by medical doctors. Now, fortunately, once you show them the evidence, because immediately they imagine you don't have the evidence which is showing the evidence and the rationale, they're like, OK, I'll send my patients there. They do a complete 180. So they're never too excited about anything because is it going to work for everybody? No, nothing works for everybody. So they're realistic and they're like, I'll send some of my patients that are relatively ambulatory and relatively pain free because that's those are two requirements are so strong. They can't be like, you know, unable to use your legs and get a benefit in the legs. You've got great the force on your brain. The problem I saw with the fitness industry and I was given warnings by others that my friends who had been kind of crossing the line between medical advice and fitness. Like Venice fans in general, not too bright. And it's yeah, I mean, they just said, like, this is like some of the stupidest people you can find and they cannot absorb science. And, you know, it's like like I used to hear Jordan Peterson talk about the bottom 20th percentile of intelligent people are only qualified to push a map, though. They have a job where they have to drive vehicle or kill people that are intelligent. So I always thought, like, I know where he's getting that. No, he's referencing science. But I never looked up the study. But I thought it seems like a lot of people, 20 percent. And then I found bodybuilding.com and I found all 20 percent of stupid people over that. It was amazing.   Speaker1: [00:46:28] Let's go to the room.   Speaker2: [00:46:31] Ok. Yeah, I'm just I'm just enjoying my haters because the more I get attacked, the business just goes through the roof. No, because more people see the stupid comments and they're like, I got to see this guy. And they expect me to just be like, wrong about everything. And then they look up the studies and they're like, no, this guy is right about everything. I love him.   Speaker1: [00:46:49] Yeah, well, you're also a doctor, right? Right. So that makes you more credible. And then you have your research behind you. But here's the rumor. Here's a rumor right now. I think it's about a rumor. I heard that you may be running for governor of California. Did you almost spit out your coffee? Yeah. Is that a yes of the coffee or yes to the governor or to both?   Speaker2: [00:47:11] I was I was in Chicago for a few unfortunate years, but yeah. Yeah, I'm a California guy and I love my state. And it's great whether it is some great people. There's a lot of great people, actually. What I really love about it is great habits. We're healthier state, we like the outdoors. People get outside and do stuff I think is really sad when a state is financially upside down and it's also the eighth largest economy in the world. That is only one explanation, just grotesque waste. I won't even call it corruption. It's like we spent four billion dollars on a train and never laid a mile of track. Yeah, it's just gone, and most of it was on environmental studies was studying crickets and moths and stuff like that. Now I certainly care about the crickets and moths. That's obviously overboard. And it was a waste of the taxpayers money. And this is why we have a punishing capital gains tax. We have all kinds of strange things. And of course, the governor shut the whole state down for exorbitant periods of time with no scientific evidence to back up his decision, making it all. So I'm not doing it because I'm egotistical about it, I think a lot of guys get into politics, they think they're great. So clearly everybody else should think that that's not my story. I think I would do a great job. I think I understand the problem crystal clear in I can fix it. I don't think the others who are planning on running, I've looked at who's planning on running and I don't think they have a clear vision of what the state needs. I'm going to run until I win. Or I think there's a better candidate. There are some downsides to me, I might be a little opinionated, I might be seen as toxic masculinity.   Speaker2: [00:49:19] I've been accused of that before. I'm a I'm an aggressive guy. I played rugby. I had a lot of things that guys do that are, you know, sort of looked at like, you know, that joke wasn't funny. Yeah, I think jokes are funny. Sorry. And so. Am I perfect for California? I don't know, but I also don't think we should be we should be picking people based on their general presentation, how they look at their skin color. Let's get somebody qualified. Clearly, we need it. But what I'm terrified about is we'll still have these punishing taxes. Companies will still leave, like it'll still be just as screwed up as it is now, because Gavin Newsom, he's the guy for all the listeners in New York and other states. He's got his governor now and he's actually a friend of mine. I used to work for him. Uh. I like the guy, but he is just done way too many things without justification when it comes to the virus. And then and then on top of that, just just nonsensical monetary policy of the state. Just waste Rudel waste. It just needs to end. So it's again, like I mentioned earlier in the podcast, a lot of people want their politics and their nutritional condensed down into a meme. It's not that simple. But it's also not that complicated. We need to look at where the money's going and just fix a couple of problems. Am I going to fix everything in California in four or eight years? Impossible. So many things are screwed up, but we can fix a couple of big things. We can fix the budget.   Speaker1: [00:50:56] I said, well, I'm excited to have interviewed the potential new governor of California. And I think, you know, if you think about it from, like, your mission to kind of help the bone from inside, which is what literally holds you up as a human, like it is your skeleton, it's your structure, it's your foundation. We think of a house. You need that strong foundation. I think it's kind of ironic that you invented this this machine or this country or whatever you want to call it, contraption or what do you call it, tool, medical device or medical device that helps you do that. Right. Helps you become strong from the inside out. And then that's kind of what you do. You've been doing this for a while and now you're trying to do this as a governor. Like, I think that actually is beautiful, like a full circle. Like you're like, OK, I see the problem. Like, I want to fix as much as I can the infrastructure. I want to make the foundation strong for my state. And like that just shows the full circle moment when you do become governor, that this is a lifelong mission of yours to kind of see something that people weren't able to see because you have a fresh perspective, a fresh pair of eyes, and you're like, that's oh, that's how I fix it. Let me make that strong. And then everything else will come together. So I just wanted to kind of tie that in there. So, you know, this is going to be great excited to see how this turns around. And you have confirmed that you are going to be running for governor of California. So congratulations on that. And because this is a beauty podcast and we did talk about the beautiful weather in your beautiful state, what does beauty mean to you from your perspective?   Speaker2: [00:52:46] Attraction? What attracts people to other people? Turns out it is visible cues that indicate long life. That's what makes people attracted to one another, so like why why do women like strong men? Because they look like they're going to live a long time, be healthy for a long time. Maybe be able to take care of things, whatever that means, depending on where you are, you know, whether it's chop the wood, make make sure everybody's warm for the wintertime or go out and earn a living or, you know, protect the family from from whatever threats may come upon them. Physical strength seems like it is highly associated with longevity, so that's and low body fat, so like we visually can tell what somebody looks like and how healthy they are. So I see. Health and physical performance as. Different names for the same thing now. The reason I like the fitness talking points of what I like X three, that's the strength product, I don't really see it as a fitness device. It's more medical, it's more scientific. It's sort of like Ultranet to fitness. But when people get involved in fitness talking points, they're typically talking about their vanity, how good they look like I want to look like this, and some like when it's a guy who show a picture, a strong male. A lot of women and I really like the trend where women try to build a lot a lot of lower body strength because they like the shape of their legs, shape of their butts. That's wonderful because they're building muscle mass. That's going to put a greater demand on all the organs of the body for focusing for enforcing the other organs of the body to perform at a higher level, which is going to keep them alive longer. And a lot of muscle mass they're going to keep later in life.   Speaker1: [00:55:02] Yeah, but also that that trend for the lower body as well. Like we know and I'm sure, you know, as a doctor probably studied this, that it has shown that women who have more of a muscle mass in the thigh and buttocks area, the lower body part, they produce healthier babies. They store more vitamins and minerals and nutrients. So that it's. So I just wanted to add that because that's when you talk about attraction and like, people don't know why that's attractive, because subconsciously, I guess through many, many, like, you know, caveman times, that's what signal to men like, you know, that's why they call it childbearing hips.   Speaker2: [00:55:41] Well, you can't change the width of your face.   Speaker1: [00:55:43] Right. But like,   Speaker2: [00:55:44] You're it's the same no matter what.   Speaker1: [00:55:46] Yes.   Speaker2: [00:55:46] Well, yes, the curvier a girl is. And when I say curvy, I don't mean fat because very often women are like, oh, yeah, I'm curvy. And I'm like, no, you're obese. But I, of course, say that to be real. Don't convince yourself you're healthy when you're not. My that's that's a that's a smokescreen put in front of yourself, lying to yourself doesn't help, right? You're just masking a brutal problem. So why do I feel sorry for people who are addicted for food? Yeah, I have compassion for them. I mean, the food has been engineered so that it's addictive. It's not by accident, you know.   Speaker1: [00:56:25] But I want to go back to Dr. Jay. I know where we're talking to Dr. Jay, not Governor Jay yet. Yet I want to know about the beauty part. Like you left us hanging here like you were talking about you. You like that women are now focusing more on their lower extremities, which actually engage more muscles. It engages more organs. And it just does so much for the body overall. So finish telling us what beauty is to you.   Speaker2: [00:56:54] Its health, like what's beautiful to me is a healthy hemoglobin A1 C score. By the way, one of the metrics that still counts is a lot of metrics don't count like high cholesterol doesn't matter. The higher your cholesterol is, the longer you're going to live. So people were wrong about that for 20 years. People still say that, and really it's the cholesterol medications that. Harm them or the fact that you know why cholesterol was such a myth for so long? No. OK, so think of an artery. Let's say it's right here. Blood, blood flows through it. What happens is inflammation from eating vegetables or sugar accelerates and different inflammatory type situations that happen to the body cause arterial inflammation. So certain points in the artery, there's inflammation and then as low density lipoprotein flows through. The artery, it sticks at these information points and it may collect and then break loose and cause an aneurysm or heart attack. So. So it was seen as like these things that are sticking there cause the blockage, which are low density lipoprotein LDL. But that wasn't the cause, the cause was the information. So if you have a low sugar diet, having higher cholesterol is fine. In fact, you live longer. There's research to prove that. But it's when you have high sugar and high fat diet, which most people who don't really control the nutrition, that's what they do. Now you're looking at cardiovascular risk, but just cut sugar out in front. This is good to   Speaker1: [00:58:38] Know, guys. So I hope that everyone is taking notes because Dr. J. Is dropping some bombs from all different perspectives about health. And I can't wait to get my X three because I'm going to work on getting my body fat a little lower. So I'm excited about that. So Dr. J. You know about the Beauty Circle. And you know what I'm going to ask you next is where do you find yourself Excel? I feel like I know the answer to this, but I'm going to let you answer. Where do you find yourself excelling in the beauty circle and where do you find yourself needing a little bit more TLC?   Speaker2: [00:59:10] The consistency, the I think also just focusing on science. I don't know where that fits in, but not just doing the right things, but understanding why you're doing the right things. People need to take a little more responsibility when it comes to beauty products, you know what's in it. Are you sure, because some of them have some dangerous chemicals in them, some of them don't, some of them are health promoting, some of them are beauty promoting, but health diminishing. Right. You've got to know, like what you're putting on your skin and also what you put on your skin sometimes transfers into your bloodstream.   Speaker1: [00:59:50] I think a lot of times, right. Because our skin is the largest organ in our body. And you're being very generous because I know that there are even and you as a doctor could probably answer this better, because I'm not a doctor. I'm just like a crazy researcher who likes to, like, ask many questions. I'm the Wegerle girl. Like, I think my podcast should have been like, why? And that's all I ask is why? Why? Even as a child, I was so annoying to my teachers, like, what is photosynthesis and why do we need it and why and why I was that annoying kid. But aren't there some minerals or some medications that absorb better transdermal? Like we know that there is such a thing as your body absorbing. And when people deny this, I always say, so why do we have a birth control patch? Not that I'm promoting that. Why do we have a nicotine patch? Why is it that magnesium there have magnesium patches? Because it's absorbs transdermal, like there are so many other things. Yeah. So to say that the skin doesn't absorb it, I just I'm going to call it out as a lie. Yeah.   Speaker2: [01:00:53] Well now some things will transfer easier than others. Right.   Speaker1: [01:00:58] And so where would you say that. You think that you could use a little bit more help in the circle and that could be you know, it could be water intake. It could be sleep. It could be spirituality. It could be relationships to yourself with others. It could be bowel movements. Like where do you think? Or skin and makeup. Yes. For you. Where do you think that you need extra TLC? I don't say the makeup that we're not going to cut that category.   Speaker2: [01:01:24] And I don't know, I'm on film a lot like so you could pick up on me and keep me from being shiny. OK, but it's it's pretty easy. They don't need it. They don't need a blended into my hairline. So from from my perspective, answer your question. Yes. There's a lot of things people want me to present on. Recently been talking about dry fasting, meaning no food, no water and of course, hydration, like we hear about hydration all the time. But we don't have any baseline for hydration. Like the whole like you need two liters of water a day. Somebody made that up. Like there's no scientific basis in that at all. And so I've been I've been doing some spending some time reading about like what's done for Ramadan because Ramadan passing is fascinating and like I want to get that information of the world and. I don't quite have like I'm on so many podcast and there's a lot of media stuff, and then the filming days, like with Terrell Owens or we got another filming day on Friday, the world would be a whole day. It'd be cameras and lighting and stuff like that for more of just like a training kind of video stuff. So I'd like to just be able to free up some more time so I can get my research done because honestly, I'm only good at one thing. And most people are really good at one thing, right, and everything else, they just kind of limping along.   Speaker2: [01:02:56] But I can read research and remember forever. That's amazing, though, when I read research. I have to take notes. Wow. And I can I can read a study and draw a parallel to a study I read 10 years ago, and I will remember the author of the study I read 10 years ago and find it in 10 seconds, and then I'll be able to read the two side by side, draw a parallel and write about it. And so you like like one study, maybe in one totally different field, one maybe endocrinology, another one might be dermatology and I can go, OK, these these two things make sense. But because X is is as a parent and so is why now I have a conclusion I can I can come to or suggest. Right. OK, that's fair. That's yeah. That's really like the one thing. And that's also why I've never had anybody like real like I've had a couple of people who don't really understand research, make some, you know, silly Facebook videos about like what a jerk I am because I'm wrong about this and this and this. And then they provide no evidence. And so even the commenters are like, OK, you like you have no science. And the guy in his book used more than two hundred fifty references. Scientific studies. No. Usually you're not the one right? It's just foolish. There is no real scientists is actually ever had a problem   Speaker1: [01:04:27] With anything I said. So the category that you would probably want is the relationship with yourself to have more time so that you can read more research papers and really start, you know, getting some intel on this drive fast thing and just the whole phenomenon of fast. What I'm interested in hearing your findings. Keep keep me in the loop, please, because I am always interested in this. I think that the body's metabolic flexibility is really something that we haven't really explored as much as we could have, if that makes sense.   Speaker2: [01:05:04] That was very well put. So what we've traditionally been doing is looking at normative data. Now, let me define that for everybody. Normative data is what the average is, so like vitamin consumption or liquid consumption? Well. Considering half of our nation is overweight or obese or morbidly obese, do we really care what the averages are? So we're comparing ourselves to people who are the fattest and sickest that humans have ever been. Also, here's another like vegan thing right now, the Western diet standard American diet is 70 percent plant based. So we go to 80 percent. Are we going to be better? Because like I said, we're the fattest and sickest ever at 70 percent. By increasing the number, we're going to get better because that seems wrong.   Speaker1: [01:06:01] And of course, it is no, I mean, we can get this is like a whole nother podcast, but when you do find the research, I'm sure that you're going to have some product out there, you know, to help us with that, because I do feel like it's going to be trending soon, not trending, but like more studies are going to come out because there are so many fasting protocols and people are talking about fasting and going into ketosis and the formula for energy and all these things. So we haven't really looked at it. And if you think about the caveman days, and I always refer to that because I think that's like a baseline for, like Hercules. Right. You think about how people went for days without food. Right. And like also that all or   Speaker2: [01:06:39] One, they didn't have a hydro flask that they carried around for the perfect hydration.   Speaker1: [01:06:43] Right. But then also you think about the need from a nutritional perspective. Right. Like, I just had this conversation with someone on the live and we talk about like maybe they could have had one carrot, but that one carrot. There's actually a study I don't know if you know about that study, but it actually said you need 220 carrots to equal the nutritional value of a one like one carrot like, you know, from a long time ago that was more nutrient based, not like cropped like a model.   Speaker2: [01:07:12] Are you talking about engineering? Yeah.   Speaker1: [01:07:14] So like a lot of   Speaker2: [01:07:16] Guys that we messed with. Yeah.   Speaker1: [01:07:19] So like also considering that from our side diet, which is the standard American diet, that even if you are getting those vegetables, how many nutrients are really in that vegetable? Because you know, that whole thing about diabetes and people that are obese, you know, we are eating, consuming a lot of food that is empty, empty and nutrition just empty, carbs just empty nothing, which is why you're still hungry. And most of the people are just craving more. And it's like, I don't know why I eat more, but I ate so much. But I'm still because your body's saying I need more nutrients, I need more minerals, I need more hydration because like, even the water is not like the same as you could find it. And and you know this, right? Like a spring water is different like you would get. And nature is different than like a Poland Spring bottle of water. Like the structure of that is completely different. The way that your body absorbs it so we can go up like this is like as you can tell, I'm passionate about this and I feel like you do see that big plate of food, but I see sometimes a big plate of food of like emptiness. And when you eat value. Right. Like, I would love to hear your perspective before we we've been on this podcast for a while, so and I'm going to be respectful of your time. But when you eat these kinds of high nutrient based foods, you're not really so hungry and you're not craving things. Right. Like, isn't that remarkable?   Speaker2: [01:08:39] One meal a day. Yeah, I'm never hungry. Now, when it's time to eat and, you know, I can smell the food I'm about to eat, you know,   Speaker1: [01:08:48] So you don't get hungry.   Speaker2: [01:08:51] No, no, I'm totally calm all the time. OK, cool. Yeah, and you know, one meal or whatever. Twenty three hours.   Speaker1: [01:08:59] Ok, cool. So, Dr. Day, our podcast is coming to an end and something that I ask all of my guests is to share one tip that or one piece of advice that they would have shared with the younger version of themselves.   Speaker2: [01:09:14] So a lot of people think that X three, I'm most known for X three, even though probably the more important thing is the bone density. I mean, osteoporosis is a disease that kills as many people as breast cancer. I came up with the most effective treatment for it. So scientifically, that was a bigger achievement than making muscles grow. Now, I think over time, x ray will be recognized as something that keeps people alive longer because they have higher levels of muscle mass and lower levels of body fat. So both may be saving lives, but there's a more direct connection with with osteo strong in the piece of advice, I would I would tell myself because a. I got to work on this for a long time and the two products go hand in hand, the self education like you don't just learn in school, you learn the whole time you're doing something from a professional perspective, especially like me inventing things, creating things that nobody ever saw before and only heard of it is advice that I was given, but I didn't believe it at the time. Just be relentless. Just don't stop like, you know, you're right. And I did. Even if it takes your whole lifetime, you'll never have a great. Like, that's the worst thing is the person who had the idea and then they end up hating themselves because they never, ever knew if their idea was worth it or not, if it would have worked.   Speaker2: [01:10:50] And

People dealing with bone and joint pain can rely on the cutting-edge osteogenic treatment offered by Los Gatos, California-based OsteoStrong. Learn more by visiting https://osteostronglosgatos.com (https://osteostronglosgatos.com)

Dr. Jaquish is here to revolutionize the fitness industry whether you like it or not.   Dr. John Jaquish is the author of the new book “Weight Lifting is a Waste of Time: So is Cardio, and there's a better way to have the body you want”. He is the Inventor of the X3 Bar at home fitness trainer. A biomechanical engineer by trade, Dr. Jaquish's first invention focused on Osteogenic loading, and has since seen wide scale global adoption and praise for helping individuals suffering from conditions like osteoporosis build back bone density.   In today's episode we discuss why “weight training” as it's always been done is a waste of time. Why static weight is an ineffective means for stimulating muscle growth. The concept and application of Variable Resistance. The importance of understanding strength throughout range of motion. The misconception you have to break down muscle to grow. The importance of getting a hormonal response. What he believes the industry has gotten wrong about fat loss. The importance of protein for muscle gain and why he's a proponent of the Carnivore Diet.   Mentioned In the Show: X3 Bar at Jaquish Biomedical: https://www.jaquishbiomedical.com/x3-bar/ Book - “Weight Lifting Is a Waste of Time: So Is Cardio, and There's a Better Way to Have the Body You Want”: https://www.amazon.com/Weight-Lifting-Waste-Time-Cardio/dp/154450893X   Follow Dr. Jaquish: Instagram: https://www.instagram.com/drjaquish/ Website: https://www.doctorj.com   Follow The Professional Athlete Podcast with Ken Gunter: Instagram: @kengunter_tpa Website: https://www.kengunter.com/ YouTube: Ken Gunter https://www.youtube.com/channel/UCRhgjkoSiJXAbS_MIasvvzQ/ Facebook: https://www.facebook.com/kengunterpodcast Audio recorded with SquadCast: https://squadcast.fm/?ref=kengunter   Produced By: Justin Gunter, Ken Gunter Music By: Justin Gunter, Ken Gunter

John Jaquish, PhD, is a Wall Street Journal Best Selling author and inventor of the most effective bone density building medical device, which has reversed osteoporosis for thousands and created more powerful and fracture resistant athletes.His devices were put into production, and has since been placed in over 300 clinics worldwide. Osteogenic loading has now helped over 20,000 individuals with their bone health.Dr. Jaquish also quantified the variance between power capacities from weak to strong ranges in weight lifting, which brought him to his second invention, X3. The research indicates that this product builds muscle much faster than conventional lifting, and does so in less training time, all with the lowest risk of joint injury.Dr. Jaquish is a research professor at Rushmore University, speaks at scientific conferences all over the world, has been featured on many of the top health podcasts, is an editor of multiple medical journals, and is a nominee of the National Medal of Science. www.jaquishbiomedical.com

Listen to Avvina Kumar, who, no matter the surgeries he went through or the financial crisis he had, defeated Osteogenic Sarcoma and helps cancer patients. ZenOnco.io - Making quality integrative oncology cancer care accessible to all. If you or your loved one has been diagnosed with cancer recently, and need guidance on treatment or have any doubts or queries, please call ZenOnco.io on +91 99 30 70 90 00.

The World's #1 Personal Development Book Podcast! In this episode, I have the pleasure to interview author Dr. John Jaquish. John began his experience in life sciences after being told by his Mother that she had been diagnosed with osteoporosis. John, in an effort to help his mother, created a device that has since been placed in over 300 clinics worldwide. Osteogenic loading has now helped over 30,000 individuals with their bone health. Dr. Jaquish is currently advancing osteogenic loading research and speaking worldwide about its implications, as well as developing other biotechnology devices and products that will aid in the advanced health and wellbeing of people all around the world. Our conversation today is all about his book, Weight Lifting Is a Waste of Time: So Is Cardio, and There's a Better Way to Have the Body You Want! This podcast was recorded a few weeks ago and since it's recording, I have officially quit the gym and I am using his X3 Bar product. I am loving it. You can stay updated on my progress through IG. Please enjoy this amazing conversation with Dr. John Jaquish. Today's episode is sponsored by Audible. Try Audible for free: www.bookthinkers.com/audibletrial. The purpose of this podcast is to connect you, the listener, with new books, new mentors, and new resources that will help you achieve more and live better. Each and every episode will feature one of the world's top authors so that you know each and every time you tune-in, there is something valuable to learn. If you have any recommendations for guests, please DM them to us on Instagram. (www.instagram.com/bookthinkers) If you enjoyed this show, please consider leaving a review. It takes less than 60-seconds of your time, and really makes a difference when I am trying to land new guests. For more BookThinkers content, check out our Instagram or our website. Thank you for your time!

Dr. John Jaquish began his experience in life sciences after being told by his Mother that she had been diagnosed with osteoporosis. John, in an effort to help his mother, created a device to place axial loading through bone to safely cause osteogenic loading events. The device was to trigger the effects of high-impact loading, but without the risk of injury. After successfully reversing his Mother's osteoporosis, as part of his doctoral dissertation in biomedical engineering research at Rushmore University, he conducted four years of testing with human subjects focused on user comfort, biomechanics, and optimal musculoskeletal stimulation. Next, the device he designed was put into production and has since been placed in over 300 clinics worldwide. Osteogenic loading has now helped over 30,000 individuals with their bone health. Published data has shown treatment with this osteogenic loading device has resulted in over 14% gains in bone density in both the spine and hip over one year of once-weekly treatment.  Dr. Jaquish is currently advancing osteogenic loading research and speaking worldwide about its implications, as well as developing other biotechnology devices and products that will aid in the advanced health and wellbeing of people all around the world. He formerly was a member of the Board of Directors of American Bone Health, and the editorial board of the Journal of Steroids and Hormonal Science. Dr. Jaquish specifically specializes in reflexive muscle activation and associated endocrine responses, bone density and fracture avoidance, myofibril protein synthesis, and sarcoplasmic hypertrophy/sarcopenic treatment.   In this episode, Dr. John Jaquish and Brad discuss how to get the body you want by following his advice and it means that you do not have to go to the gym...say what??? Tune in to find out exactly what you need to do.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.30.362384v1?rss=1 Authors: Wang, Y., Chun, R. F., Adhikari, S., Lopez, C. M., Henrich, M., Yacoubian, V., Lin, L., Adams, J. S., Xing, Y. Abstract: Nearly all human multi-exonic genes undergo alternative splicing (AS) via regulation by RNA-binding proteins (RBPs), but few studies have examined the temporal dynamics of AS and its regulation during cell differentiation in the bone niche. We sought to evaluate how AS, under the control of RBPs, affects cell fate commitment during induced osteogenic differentiation of human bone marrow-derived multipotent stem/stromal progenitor cells (MSPCs). We generated a time-course RNA sequencing (RNA-seq) dataset representative of induced MSPC differentiation to osteoblasts. Our analysis revealed widespread AS changes, coordinated with differential RBP expression, at multiple time points, including many AS changes in non-differentially expressed genes. We also developed a computational approach to profile the dynamics and regulation of AS by RBPs using time-course RNA-seq data, by combining temporal patterns of exon skipping and RBP expression with RBP binding sites in the vicinity of regulated exons. In total we identified nine RBPs as potential key splicing regulators during MSPC osteogenic differentiation. Perturbation of one candidate, KHDRBS3, inhibited osteogenesis and bone formation in vitro, validating our computational prediction of "driver" RBPs. Overall, our work highlights a high degree of complexity in the splicing regulation of MSPC osteogenic differentiation. Our computational approach may be applied to other time-course data to explore dynamic AS changes and associated regulatory mechanisms in other biological processes or disease trajectories. Copy rights belong to original authors. Visit the link for more info

GET TRANSCRIPT AND FULL SHOWNOTES: MelanieAvalon.com/bones 2:45 - Go To melanieavalon.com/micronutrients And Use The Code Avalon For A Discount Sitewide! 3:00 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At facebook.com/groups/PaleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 3:15 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:20 - DRY FARM WINES: Low Sugar, Low Alcohol, Toxin-Free, Mold- Free, Pesticide-Free , Hang-Over Free Natural Wine! Use The Link dryfarmwines.com/melanieavalon To Get A Bottle For A Penny! 4:30 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beauty Counter Email List At melanieavalon.com/cleanbeauty! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 8:10 - Mira's Story: Reversing Osteoporosis - The Core Of Health Conditions  13:00 - What Is Bone? The Types Of Bone, Role Of Protein, Etc.  15:20 - The Role Of Flexibility In Bone Health 15:40 - Peak Bone Mass 18:00 - How Is Bone Broken Down And Rebuilt: Osteoclasts And Osteoblasts  19:45 - Osteopenia And Osteoporosis And DEXA Scans - The Importance Of Getting A Baseline  And How It Can Affect You 24:05 - How Do They Determine The Standards?  26:15 - Is Osteoporosis Deadly?  27:20 - The Connection To Mineral Deficiency​ 29:05 - Conventional Pharmaceuticals: How Do Bisphosphonates Work Or Cause Bones To Become Brittle? 33:30 - What Role Do Micronutrients Play? Can We Supplement? 39:35 - The Role Of Food Vs Lifestyle And Supplements 39:30 - FOOD SENSE GUIDE: Get Melanie's App At melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More! 41:30 - Micronutrients From Food Vs Supplements, And The Problems With Multivitamins  44:05 - Competing Nutrients  45:45 - Breaking Down Nutrients, Antinutrients  47:30 - Calcium Supplementation Concerns, Forms, Vitamin D, Vitamin K2 51:10 - K1 Vs K2 (MK4 Vs MK7) 53:40 - The Problem Of K With D 54:50 - The Fat Delivery System  55:30 - Low Fat Diet Problems 1:00:10 - Meal Timing, OMAD And Reaching Micronutrient Sufficiency  1:03:20 - Separating Vitamins  1:06:00 - The Role Of Protein In Building Bone  1:10:55 - Excess Protein, Blood PH, The Acid/Alkaline Diet 1:13:25 - Leeching Calcium From Bones: Salt And The Crave Cycle  1:14:30 - Blood Tests For Calcium Levels 1:15:30 - SUNLIGHTEN: Get $200 Off Any Sunlighten Cabin Model Or $100 Off The Solo Unit (That Melanie Has!) AND $99 Shipping (Regularly $598) With The Code MelanieAvalon At melanieavalon.com/sunlighten. Forward Your Proof Of Purchase To Podcast@MelanieAvalon.Com, To Receive A Signed Copy Of What When Wine! 1:17:30 - SpectraCell 1:17:40 - Dairy For Bone Health? 1:18:40 - Alcohol And Bone Health 1:23:30 - Omega 3s 1:27:40 - DHA And EPA Competition: Krill Vs Fish Oil 1:32:00 - The Problem With Olive Oil 1:33:30 - The Role Of Osteogenic Loading  1:39:00 - How Fast Can Changes Happen? 1:44:30 - Go To melanieavalon.com/micronutrients And Use The Code Avalon For A Discount Sitewide!  

Hello everyone and welcome back to the show. Thank you for tuning into the CJE Podcast. We continue to grow because of you the listener and supporter – Thank you! A big thanks to all the brave men and women who serve and protect us ever day. Thank you for your dedicated service. You are honored, cherished and loved. Keep up the great work. Special thanks to our sponsor Detectachem. This great company is keeping our brave men and women safe by offering threat detection that fits in the palm of your hand. Their technology detects illicit drugs and explosives and it’s a must have for any law enforcement and military personnel. You can check them out at www.cjevolution.com As you head into 2020, I know a lot of you in the criminal justice field struggle with personal and professional obstacles. As a law enforcement professional of 23 years, I know I did! My world didn’t start to change until I started to seek out mentors and coaches that could help me through the difficult times.  I want to work with you one on one and be your personal coach. Check out my personal coaching at www.cjevolution.com and let’s get on a discovery call soon. I want to help you get on the path of personal and professional success for 2020. EVOLVE Coaching - https://www.cjevolution.com/personal-coaching/ Welcome back everyone. I am very excited to have with Dr. Jaquish on the show. Dr. John Jaquish began his experience in life sciences after being told by his Mother that she had been diagnosed with osteoporosis. John, to help his mother, created a device to place axial loading through bone to safely cause osteogenic loading events. The device was to trigger the effects of high-impact loading, but without the risk of injury. After successfully reversing his Mother's osteoporosis, as part of his doctoral dissertation in biomedical engineering research at Rushmore University, he conducted four years of testing with human subjects focused on user comfort, biomechanics, and optimal musculoskeletal stimulation. Next, the device he designed was put into production, and has since been placed in over 300 clinics worldwide. Osteogenic loading has now helped over 30,000 individuals with their bone health. Published data has shown, treatment with this osteogenic loading device has resulted in over 14% gains in bone density in both the spine and hip over one year of once-weekly treatment. Dr. Jaquish is currently advancing osteogenic loading research and speaking worldwide about its implications, as well as developing other biotechnology devices and products that will aid in the advanced health and wellbeing of people all around the world. He formerly a member of the Board of Directors of American Bone Health, and the editorial board of the Journal of Steroids and Hormonal Science. Dr. Jaquish is also a partner with Tony Robbins, and Dr. Jaquish is the inventor of Osteostrong Devices and the X3 System. The x3 Bar System is a must have, if you want to get your body and mind into peak condition. Find it here: https://www.jaquishbiomedical.com/products/   Find Dr. Jaquish here:   https://www.johnjaquish.com/   https://www.jaquishbiomedical.com/   https://www.linkedin.com/in/john-jaquish-ph-d-790b846/   Stay tuned for more great episodes on The CJEvolution Podcast   www.cjevolution.com   Patrick          

People are constantly encouraged to lift weights, but often the methods and equipment they use fail to change their physique and even cause injury. What is at the root of inefficient weight lifting that plagues so many workouts? How can you get your central nervous system to help you build muscle? What is the X3 Bar, and why it is the secret to growing muscle and reducing joint pain? On this episode, I’m joined by author, entrepreneur and founder of the X3 Bar, Dr. John Jaquish, who shares how his invention is making a real impact in helping people grow stronger. Being strong and lean are the two biggest determinants of long life. -Dr. John Jaquish   Three Takeaways You don’t just go to the gym to lift weights. You go to contract muscle fibers to build up your muscles and bone density. A lot of the soreness people experience after lifting isn’t caused by lactic acid. It’s just joint damage, which doesn’t do anything for your muscles. Think of the central nervous system as an engineering team of deaf and blind entities in your body that can only communicate based on the environment you create in the body. When you do fasted cardio, you reduce growth hormone and increase cortisol. When you lift, you increase growth hormone, which is important in improving your skeletal health. At the start of the show, John shared what led to the creation of The X3 Bar, and why triggering adaptation in older people is so powerful. Next, we talked about the lessons John learned from gymnasts and why people are more powerful in the impact-ready range of motion. We discussed how to communicate with the central nervous system, and how the X3 Bar triggers androgen receptor sensitivity.   We also discussed: The dangers of high pain tolerance The connection between The X3 Bar, testosterone and androgen receptors The growth hormone effect of the X3 Bar Going to the gym shouldn’t just be about how much we lift, but about contracting our muscles so that they grow. If our weightlifting is overloading our joints and underloading our muscle, there’s so much potential we’re leaving on the table. How we lift weights needs to help our central nervous system increase growth hormone. To do that you need to train at the right intensity in impact-ready positions. The body is incredibly efficient if we know exactly how to train it.   Guest Bio- John Jaquish, PhD, is an author and the inventor of the most effective bone density building medical device, which has reversed osteoporosis for thousands and created more powerful and fracture resistant athletes. His devices were put into production, and has since been placed in over 300 clinics worldwide. Osteogenic loading has now helped over 20,000 individuals with their bone health. For more information, go to https://www.x3bar.com.

A few weeks ago, a friend emailed me and said: "I just got off the phone with John Jaquish, PhD, the inventor of something called the . He is an inventor, author, and scientist who stumbled upon his life’s mission to promote bone health and advance osteogenic loading research after his mother was diagnosed with osteoporosis. Determined to help her and others suffering from musculoskeletal conditions and pain, John developed amazing biotechnology devices that increase bone density, strengthen muscles, and improve stability while reducing injury risk." The email went on to describe how you could use John's research to increase your bone density in just 10 minutes a week, and how you can put on more muscle in less time by leveraging John’s biomedical engineering wisdom – and this thing called an that he invented. So I looked into Dr. Jaquish, and also got an for myself to play around with. Turns out, he began his experience in life sciences after being told by his Mother that she had been diagnosed with osteoporosis. John, in an effort to help his mother, created a device to place axial loading through bone to safely cause osteogenic loading events. The device was to trigger the effects of high-impact loading, but without the risk of injury. After successfully reversing his Mother's osteoporosis, as part of his doctoral dissertation in biomedical engineering research at Rushmore University, he conducted four years of testing with human subjects focused on user comfort, biomechanics, and optimal musculoskeletal stimulation. Next, the device he designed was put into production, and has since been placed in over 240 clinics worldwide. Osteogenic loading has now helped over 12,000 individuals with their bone health. Published data has shown, treatment with this osteogenic loading device has resulted in over 14% gains in bone density in both the spine and hip over one year of once-weekly treatment. Dr. Jaquish is currently advancing osteogenic loading research and speaking worldwide about its implications, as well as developing other biotechnology devices and products that will aid in the advanced health and wellbeing of people all around the world. He currently sits on the Board of Directors of American Bone Health, and the editorial boards of the Journal of Steroids and Hormonal Science, and Diabetes Open. During our discussion, you'll discover: -How John developed an osteogenic loading device to fix his mother's osteoporosis... 7:40 -How the X3 Bar came to be invented and the fascinating science behind it... 12:56 -The use of variable resistance training to get 3x increases in power and strength... 20:25 -The special kind of elastic bands that John integrated into the X3 Bar... 23:50 -The effect of variable resistance training on growth hormone and testosterone... 36:13 -What kind of workouts you would do on it if you're doing the 10 minute workout once per day... 49:05 -What John's 10 minute 1x/day workout looks like... 50:31 -Ways that you can "biohack" variable resistance training with tools such as vibration, blood flow restriction, balance board... 58:29 -And much more! Resources from this episode: - - use code “Ben” to get an instant $50 discount -Power Plate vibration platform - Episode Sponsors  use code word "Ben" and get 10% off your first order, and free shipping for orders over $99.  Use code word "greenfield" and get 20% off your order. Do you have questions, thoughts or feedback for John or me? Leave your comments at  and one of us will reply!

Cellular bone allograft (CBA) possesses osteogenic, osteoinductive, and osteoconductive elements essential for bone healing. The purpose of this study was to assess the safety and effectiveness of CBA in foot and/or ankle arthrodeses.     To view the article, click here.

Background: Tissue engineering approaches for reconstruction of large bone defects are still technically immature, especially in regard to sufficient blood supply. Therefore, the aim of the present study was to investigate the influence of osteogenic stimulation and treatment with VEGF on new bone formation and neovascularization in hMSC-loaded cancellous bone scaffolds in vivo. Methods: Cubic scaffolds were seeded with hMSC and either cultured in stem cell medium or osteogenic stimulation medium. One osteogenically stimulated group was additionally treated with 0.8 mu g VEGF prior to subcutaneous implantation in athymic mice. After 2 and 12 weeks in vivo, constructs and selected organs were harvested for histological and molecular analysis. Results: Histological analysis revealed similar vascularization of the constructs with and without VEGF treatment and absence of new bone formation in any group. Human DNA was detected in all inoculated scaffolds, but a significant decrease in cells was observed after 2 weeks with no further decrease after 12 weeks in vivo. Conclusion: Under the chosen conditions, osteogenic stimulation and treatment with VEGF does not have any influence on the new bone formation and neovascularization in hMSC-seeded cancellous bone scaffolds.

Osteogenic repair in response to bone injury is characterized by activation and differentiation of mesenchymal stem cells (MSCs) to osteoblasts. This study determined whether activation of Sirt-1 (a NAD(+)-dependent histone deacetylase) by the phytoestrogen resveratrol affects osteogenic differentiation. Monolayer and high-density cultures of MSCs and pre-osteoblastic cells were treated with an osteogenic induction medium with/without the Sirt-1 inhibitor nicotinamide or/and resveratrol in a concentration dependent manner. MSCs and pre-osteoblastic cells differentiated to osteoblasts when exposed to osteogenic-induction medium. The osteogenic response was blocked by nicotinamide, resulting in adipogenic differentiation and expression of the adipose transcription regulator PPAR-γ (peroxisome proliferator-activated receptor). However, in nicotinamide-treated cultures, pre-treatment with resveratrol significantly enhanced osteogenesis by increasing expression of Runx2 (bone specific transcription factor) and decreasing expression of PPAR-γ. Activation of Sirt-1 by resveratrol in MSCs increased its binding to PPAR-γ and repressed PPAR-γ activity by involving its cofactor NCoR (nuclear receptor co-repressor). The modulatory effects of resveratrol on nicotinamide-induced expression of PPAR-γ and its cofactor NCoR were found to be mediated, at least in part, by Sirt-1/Runx2 association and deacetylation of Runx2. Finally, knockdown of Sirt-1 by using antisense oligonucleotides downregulated the expression of Sirt-1 protein and abolished the inhibitory effects of resveratrol, namely nicotinamide-induced Sirt-1 suppression and Runx2 acetylation, suggesting that the acetylated content of Runx2 is related to downregulated Sirt-1 expression. These data support a critical role for Runx2 acetylation/deacetylation during osteogenic differentiation in MSCs in vitro. (242 words in abstract).

Osteogenic differentiation of hMSC into osteoblasts is a prerequisite for subsequent bone formation. Numerous studies have explored osteogenic differentiation under standard tissue culture conditions, which usually employ 21% of oxygen. However, bone precursor cells such as hMSC reside in stem cell niches of low oxygen atmospheres. Furthermore, they are subjected to low oxygen concentrations when cultured on three dimensional scaffolds in vitro for bone tissue engineering purposes, and even more so after transplantation when vascularisation has yet to be established. Similarly, hMSC are exposed to low oxygen in the fracture microenvironment following bony injury. Recent studies revealed that hypoxic preconditioning improves cellular engraftment and survival in low oxygen atmospheres. In the present study we therefore investigated the osteogenic differentiation potential of hMSC under 2% O2 (hypoxia) in comparison to a standard tissue culture oxygen atmosphere of 21% (normoxia). The success of differentiation was validated through Alizarin red staining and RT-PCR analysis of osteoblast markers ALP and OPN. We assessed osteogenic differentiation of hMSC following hypoxic preconditioning to address whether this pretreatment is beneficial for subsequent differentiation under low oxygen tension. To validate our findings we carefully characterised the extent of hypoxia exerted on cells with respect to cell survival (WST assay) and proliferation (growth curve). Furthermore we also tried to elucidate the role of HIF-1 alpha with respect to osteogenic differentiation under hypoxia via silencing RNA and DFO, a pharmacological agent. Finally we tested whether an immortalized hMSC-line (SCP-1) would serve as a model system for hMSC. We found that hMSC proliferate better if cultured under 2% of oxygen. We confirmed that osteogenic differentiation of hMSC is indeed inhibited under hypoxia. We showed for the first time that hypoxic preconditioning of hMSC prior to osteogenic induction restores osteogenic differentiation of hMSC under hypoxia. HIF-1 alpha seemed not to play a significant role in osteogenic differentiation under hypoxia, as transiently knocking down of HIF-1 alpha in preconditioned samples did not show any differences in their osteogenic differentiation. Moreover stabilising Hif-1 alpha in hypoxic samples did not yield any osteogenic differentiation either substantiating the notion that HIF-1 alpha does not have a direct role in the osteogenic differentiation of hMSC under hypoxia. Together our data suggest that hypoxia favours stemness over differentiation by upregulating embryonic stem cell markers like OCT-4 and NANOG. Hypoxic preconditioning may help to restore the otherwise reduced osteogenic potential of hMSC, either within a hypoxic fracture environment or at the site of implantation of tissue engineered bone constructs. We therefore believe that hypoxic preconditioning is a helpful tool for successful regenerative cell-based therapies in bone tissue engineering. SCP-1 cells might be used as a model system for hMSC as they are easy to handle, can be cultured to a desired cell number within a very short period of time, are relatively inexpensive and above all do not go into senescence as seen with hMSC after approximately 20 passages. Apart from their distinct advantages SCP-1 cells still maintain the specific CD markers characteristic for hMSC and are able to differentiate into adipogenic, osteogenic and chondrogenic lineages. However for in vivo experiments in animals a constant monitoring of neoplastic transformation is mandatory

Die Behandlung ausgedehnter knöcherner Substanzdefekte stellt in der Unfall- und Wiederherstellungschirurgie sowie auch in der Orthopädie nach wie vor ein nur unbefriedigend gelöstes Problem dar. Die Transplantation autogener Spongiosa wie auch die Kallusdistraktion als derzeitge Standardverfahren sind mit erheblichen verfahrensimmantenten Nachteilen verbunden, so daß seit Jahrzehnten nach geeigneten Alternativen gesucht wird. Durch die Methoden der Gentechnologie eröffnete sich schließlich die Möglichkeit, osteoinduktive Wachstumsfaktoren kommerziell herzustellen und therapeutisch einzusetzen, wobei sich im Kleintierversuch das rekombinante humane Osteogenic Protein-1 (Bone Morphogenetic Protein-7) bereits als sehr vielversprechend erwiesen hat. Allerdings spiegelten die verwendeten Versuchsmodelle bisher keine der Humansituation vergleichbaren klinisch-realistischen Problemdefekte wieder. Anhand eines überkritischen Extremmodells sollte daher in der vorliegenden Studie versucht werden, die Möglichkeiten bzw. Grenzen des klinischen Einsatzes von rekombinantem humanem Osteogenic Protein-1 als Bestandteil von Bioimplantaten zur Überbrückung langstreckiger segmentaler Knochendefekte aufzuzeigen. Um die Konkurrenzfähigkeit des Wachstumsfaktors gegenüber den Standard-verfahren zu beschreiben diente als relevanter Parameter die Knochenneubildung in qualitativer, quantitativer und zeitlicher Hinsicht. Dabei sollte der getestete Wachstumsfaktor zumindest vergleichbare oder bessere Ergebnisse erzielen als das Standardverfahren der autogenen Spongiosatransplantation. Um eventuelle Unterschiede der Verfahren möglichst deutlich erkennen zu können wurde gezielt eine überkritische Defektsituation gewählt, in der auch durch aufwändige autogene Spongiosatransplantation keine regelmäßige Ausheilung mehr erzielt werden kann. Dazu wurde bei insgesamt 15 weiblichen Merinoschafen an der linken Tibia ein 5,0 cm langer segmentaler Knochendefekt mit einem Defektvolumen von 20 ml geschaffen und mit einem aufgebohrten Marknagel unter einer beabsichtigten Rotationsinstabilität von 10° osteosynthetisch versorgt. Der Defekt wurde mit folgenden Implantaten aufgefüllt: In Gruppe 1 mit 5 mg Osteogenic Protein-1 kombiniert mit inaktivierter demineralisierter Knochenmatrix als Kollagenträger, in Gruppe 2 mit autogener Spongiosa und in Gruppe 3 nur mit inaktivierter demineralisierter Knochenmatrix zum Ausschluß bzw. zur Beurteilung einer eventuellen Eigenaktivität des Kollagenträgers. Die Auswertung erfolgte anhand von seriellen Röntgenverlaufskontrollen im Abstand von 2 Wochen bis zum Versuchsende nach 12 Wochen, anschließender quantitativer Bestimmung der Knochenneubildung innerhalb des Defektbereiches durch 3D-CT-Volumetrie, biomechanischer Testung im 4-Punkt-Biegeversuch sowie durch unentkalkte Knochenhistologie und Histomorphometrie mittels Mikroradiographie. In den Röntgenverlaufskontrollen zeigten vier von fünf mit Osteogenic Protein-1 behandelten Versuchstieren deutliche Anzeichen einer Implantat-induzierten Knochenneubildung innerhalb des Defektbereiches, allerdings konnte 12 Wochen postoperativ lediglich in zwei von fünf Fällen der Defekt als ausreichend überbrückt und damit als geheilt bezeichnet werden. Nach Transplantation von autogener Spongiosa kam es in allen vier Fällen zu einer Defektüberbrückung bis hin zur knöchernen Defektkonsolidierung in ebenfalls zwei Fällen. Durch Implantation der Trägersubstanz alleine konnte keine Defektüberbrückung erzielt werden. Im zeitlichen Verlauf der Knochenneubildung zeigten sich keine relevanten Unterschiede. Auffällig war dagegen eine mitunter erhebliche Dislokation des osteoinduktiven Implantates aus dem Defektbereich heraus mit Entwicklung ausgeprägter heterotoper Ossifikationen in vier von fünf Fällen nach Implantation von Osteogenic Protein-1. Dieser Effekt konnte in den anderen Gruppen nicht beobachtet werden. Während in der Auswertung des Röntgenverlaufs somit durch Implantation von Osteogenic Protein-1 annähernd gleich gute Resultate hinsichtlich der qualitativen Defektüberbrückung im zeitlichen Verlauf erzielt werden konnten wie durch autogene Spongiosatransplantation, so zeigte sich in der quantitativen Knochenvolumen-bestimmung innerhalb des Defektbereiches mittels 3D-CT-Scan eine eindeutige Überlegenheit der autogenen Spongiosatransplantation gegenüber der Implantation des Wachstumsfaktors. Durch autogene Spongiosatransplantation wurde mit durchschnittlich 21,45  9,20 ml mehr als doppelt so viel neuer Knochen gebildet als durch Osteogenic Protein-1 (durchschnittlich 9,35  2,48 ml). Durch den Einsatz von Osteogenic Protein-1 konnte aber immerhin um 50% mehr neuer Knochen gebildet werden als durch die Trägersubstanz alleine (6,28  1,94 ml). Das primäre Einbringen von mineralischer Substanz bei autogener Spongiosatransplantation scheint dabei keinen Einfluß auf eine falsch-positive Verzerrung der Ergebnisse zu haben, da die Relationen der Fraktionen unterschiedlich dichten Knochens dabei in allen Gruppen vergleichbar waren. Das vermeintlich relativ gute Ergebnis nach Implantation der Trägersubstanz alleine ist durch die Miterfassung der Defektkanten und der von diesen ausgehenden Spontanregeneration zu erklären. Biomechanisch konnten alle vier Tibiae nach Spongiosatransplantation und eine mit Osteogenic Protein-1 behandelte Tibia untersucht werden. Dabei reflektierten alle getesteten Tibiae lediglich Charakteristika bindegewebig organisierter Pseudarthrosen mit einer relativen Bruchlast von 9,6-18,4 % gegenüber der jeweiligen unversehrten kontralateralen Tibia. In der Kontrollgruppe (nur Kollagenträger) war keine operierte Tibia ausreichend stabil für die biomechanische Auswertung. Histologisch zeigten sich in der Färbung nach Laczko-Levai im Gruppenvergleich keine qualitativen Unterschiede des neu gebildeten Knochens. In allen Fällen handelte es sich um noch ungerichteten Geflechtknochen mit allen typischen Bestandteilen. In der Alizarin-Toluidin-Färbung sowie in der Färbung nach Laczko-Levai war bei vier von fünf mit Osteogenic Protein-1 behandelten Versuchstieren eine lokalisations-abhängige Ausbildung von gelenktypischem Knorpelgewebe am Interface zwischen Marknagel und neu gebildetem Knochen auffällig. Dieser neugebildete Knorpel fand sich nur an Lokalisationen, wo in unmittelbarer Nähe auch neuer Knochen gebildet wurde. Wie bei einer regelrechten synovialen Gelenkfläche befand sich der neugebildete Knorpel an der Oberfläche zum mobilen Marknagel hin und stand über eine subchondrale Platte in fester Verbindung mit dem darunter liegenden simultan gebildeten Knochen. Dieser Effekt konnte in den anderen beiden Gruppen jeweils nur in einem Fall und auch nur in deutlich geringerem Ausmaß beobachtet werden. Dieses in der vorliegenden Studie beobachtete Phänomen einer simultanen Knochen- und Knorpelbildung durch rekombinantes humanes OP-1 in Abhängigkeit einer unterschiedlich ausgeprägten mechanischen Belastungsstruktur wurde bislang noch nicht im Rahmen eines extraartikulären Modells beschrieben. Mikroradiographisch wurden im Gruppenvergleich ebenfalls keine qualitativen Unterschiede des neu gebildeten Knochens festgestellt. Die quantitativen Messungen korrelieren gut mit denen der 3D-CT-Volumetrie. In allen Gruppen erfolgte die Knochenneubildung ferner erwartungsgemäß lokalisationsabhängig verstärkt im ersatzstarken Lager. Zusammenfassend kann dem rekombinanten humanen Wachstumsfaktor Osteogenic Protein-1 auch im großen segmentalen Problemdefekt eine ausgeprägte lokale osteogenetische Potenz zugeschrieben werden, allerdings erscheint eine humanmedizinische Anwendung der gegenwärtig angebotenen Applikationsform im langstreckigen segmentalen Kontinuitätsdefekt der lasttragenden unteren Extremität aufgrund noch ungelöster Probleme hinsichtlich Applikation, Dislokation, Dosierung und Releasing aus der Trägersubstanz derzeit noch nicht gerechtfertigt. Diese Studie zeigt aber ferner, daß Osteogenic Protein-1 bei entsprechenden biochemischen und insbesondere biomechanischen Milieubedingungen das Potential zur Generierung von gelenktypischem Knorpel haben kann. Interessant erscheint dabei vor allem die wohl von der lokal unterschiedlichen Belastungsstruktur abhängige simultane Induktion sowohl von Knochen- als auch von Knorpelgewebe durch Osteogenic Protein-1. Damit eröffnet sich ein weiteres Forschungsfeld im Zusammenhang mit diesem Wachstumsfaktor im Hinblick auf die Regeneration von osteochondralen Defekten. Diese Tatsache bekräftigt aber auch die unabdingbare Notwendigkeit einer stabilen Osteosynthese bei Anwendung von Osteogenic Protein-1 mit dem Ziel der reinen Osteoinduktion.

Extensive studies have shown that undifferentiated cellular components of human bone marow are involved in the formation and renewal of bone tissue (osteogenic cascade). In this study, human mesenchymal stem cells were stimulated by bFGF, IGFI, PDGF-BB or TGF-ß1, in 2 different concentrations respectively (1 and 10 µg/mL). in vitro to assess their influence on differentiation to the osteoblastic phenotype. Thus human marrow could be used as a malleable basic element in bone engineering. The study clearly showed a stimulatory or suppressive effect of each of the respective growth factors. In particular the addition of TGF-ß1 directed the differentiation of mesenchymal stem cells of human bone marrow toward the osteoblastic phenotype.