Podcasts about scaffolds

Solving Poker and Diplomacy, Debating RL+Reasoning with Ilya, what's *wrong* with the System 1/2 analogy, and where Test-Time Compute hits a wall Timestamps 00:00 Intro – Diplomacy, Cicero & World Championship 02:00 Reverse Centaur: How AI Improved Noam's Human Play 05:00 Turing Test Failures in Chat: Hallucinations & Steerability 07:30 Reasoning Models & Fast vs. Slow Thinking Paradigm 11:00 System 1 vs. System 2 in Visual Tasks (GeoGuessr, Tic-Tac-Toe) 14:00 The Deep Research Existence Proof for Unverifiable Domains 17:30 Harnesses, Tool Use, and Fragility in AI Agents 21:00 The Case Against Over-Reliance on Scaffolds and Routers 24:00 Reinforcement Fine-Tuning and Long-Term Model Adaptability 28:00 Ilya's Bet on Reasoning and the O-Series Breakthrough 34:00 Noam's Dev Stack: Codex, Windsurf & AGI Moments 38:00 Building Better AI Developers: Memory, Reuse, and PR Reviews 41:00 Multi-Agent Intelligence and the “AI Civilization” Hypothesis 44:30 Implicit World Models and Theory of Mind Through Scaling 48:00 Why Self-Play Breaks Down Beyond Go and Chess 54:00 Designing Better Benchmarks for Fuzzy Tasks 57:30 The Real Limits of Test-Time Compute: Cost vs. Time 1:00:30 Data Efficiency Gaps Between Humans and LLMs 1:03:00 Training Pipeline: Pretraining, Midtraining, Posttraining 1:05:00 Games as Research Proving Grounds: Poker, MTG, Stratego 1:10:00 Closing Thoughts – Five-Year View and Open Research Directions Chapters 00:00:00 Intro & Guest Welcome 00:00:33 Diplomacy AI & Cicero Insights 00:03:49 AI Safety, Language Models, and Steerability 00:05:23 O Series Models: Progress and Benchmarks 00:08:53 Reasoning Paradigm: Thinking Fast and Slow in AI 00:14:02 Design Questions: Harnesses, Tools, and Test Time Compute 00:20:32 Reinforcement Fine-tuning & Model Specialization 00:21:52 The Rise of Reasoning Models at OpenAI 00:29:33 Data Efficiency in Machine Learning 00:33:21 Coding & AI: Codex, Workflows, and Developer Experience 00:41:38 Multi-Agent AI: Collaboration, Competition, and Civilization 00:45:14 Poker, Diplomacy & Exploitative vs. Optimal AI Strategy 00:52:11 World Models, Multi-Agent Learning, and Self-Play 00:58:50 Generative Media: Image & Video Models 01:00:44 Robotics: Humanoids, Iteration Speed, and Embodiment 01:04:25 Rapid Fire: Research Practices, Benchmarks, and AI Progress 01:14:19 Games, Imperfect Information, and AI Research Directions

I'm pulling back the curtain on how I use AI in my work with teachers as an instructional coach. I'll show you how I collaborate with AI to brainstorm ideas, reflect on lesson design, and help teachers build scaffolds and supports that truly meet students where they are. This is an honest, behind-the-scenes look at how educators are already partnering with AI in powerful and practical ways, as well as the limitations of these tools and what's NOT working. You'll learn: What it means to treat AI as a reflective collaborator, not just a resource generator How tools like Diffit, Brisk Teaching, Insta-Lesson, and MagicStudent can support differentiation, feedback, and independent learning Prompts and workflows I use when coaching teachers to personalize tasks without creating extra work Strategies for using AI to scaffold multi-step directions, revise writing, and support executive functioning How to guide students in getting feedback from AI directly and build their independence Get the shareable article/transcript for this episode here. Grab the free AI prompt guide to try these strategies yourself. Sign up for the free live training on June 10th @ 5pm ET. Join the 40 Hour AI membership to get up-to-date trainings. Bring me to your school for customized on-site or virtual PD.

As educators, making the most of our limited time with ELL students is crucial. But what exactly should you be teaching English language learners to ensure effective learning outcomes?In this episode of Equipping ELLs, host Beth Vaucher provides essential guidance for educators on determining what to teach their ELLs. This episode builds on previous discussions about understanding your students and the Silent Period, focusing on how to choose appropriate lessons based on students' backgrounds and proficiency levels. We explore four key types of lessons—Foundational English, Content-Focused with Scaffolds, Domain-Specific Instruction, and Skill-Specific Lessons—each tailored to different learning needs and stages. Listeners will gain practical tips for aligning instruction with student needs, making informed teaching decisions, and creating a supportive learning environment. Tune in to enhance your ELL teaching strategies, to better support your students' academic growth, and to make the most of your instructional and planning time.Resources: ⁠⁠⁠Join the Equipping ELLs MembershipShop our TpT Store

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Auto-Enhance: Developing a meta-benchmark to measure LLM agents' ability to improve other agents, published by Sam Brown on July 22, 2024 on The AI Alignment Forum. Summary Scaffolded LLM agents are, in principle, able to execute arbitrary code to achieve the goals they have been set. One such goal could be self-improvement. This post outlines our plans to build a benchmark to measure the ability of LLM agents to modify and improve other LLM agents. This 'Auto-Enhancement benchmark' measures the ability of 'top-level' agents to improve the performance of 'reference' agents on 'component' benchmarks, such as CyberSecEval 2, MLAgentBench, SWE-bench, and WMDP. Results are mostly left for a future post in the coming weeks. Scaffolds such as AutoGPT, ReAct, and SWE-agent can be built around LLMs to build LLM agents, with abilities such as long-term planning and context-window management to enable them to carry out complex general-purpose tasks autonomously. LLM agents can fix issues in large, complex code bases (see SWE-bench), and interact in a general way using web browsers, Linux shells, and Python interpreters. In this post, we outline our plans for a project to measure these LLM agents' ability to modify other LLM agents, undertaken as part of Axiom Futures' Alignment Research Fellowship. Our proposed benchmark consists of "enhancement tasks," which measure the ability of an LLM agent to improve the performance of another LLM agent (which may be a clone of the first agent) on various tasks. Our benchmark uses existing benchmarks as components to measure LLM agent capabilities in various domains, such as software engineering, cybersecurity exploitation, and others. We believe these benchmarks are consequential in the sense that good performance by agents on these tasks should be concerning for us. We plan to write an update post with our results at the end of the Fellowship, and we will link this post to that update. Motivation Agents are capable of complex SWE tasks (see, e.g., Yang et al.). One such task could be the improvement of other scaffolded agents. This capability would be a key component of autonomous replication and adaptation (ARA), and we believe it would be generally recognised as an important step towards extreme capabilities. This post outlines our initial plans for developing a novel benchmark that aims to measure the ability of LLM-based agents to improve other LLM-based agents, including those that are as capable as themselves. Threat model We present two threat models that aim to capture how AI systems may develop super-intelligent capabilities. Expediting AI research: Recent trends show how researchers are leveraging LLMs to expedite academic paper reviews (see Du et al.). ML researchers are beginning to use LLMs to design and train more advanced models (see Cotra's AIs accelerating AI research and Anthropic's work on Constitutional AI). Such LLM-assisted research may expedite progress toward super-intelligent systems. Autonomy: Another way that such capabilities are developed is through LLM agents themselves becoming competent enough to self-modify and further ML research without human assistance (see section Hard Takeoff in this note ), leading to an autonomously replicating and adapting system. Our proposed benchmark aims to quantify the ability of LLM agents to bring about such recursive self-improvement, either with or without detailed human supervision. Categories of bottlenecks and overhang risks We posit that there are three distinct categories of bottlenecks to LLM agent capabilities: 1. Architectures-of-thought, such as structured planning, progress-summarisation, hierarchy of agents, self-critique, chain-of-thought, self-consistency, prompt engineering/elicitation, and so on. Broadly speaking, this encompasses everything between the LL...

Kate and Ryan are joined by Dave Sharrock to talk about the use of Scaffolds to help scale and transform change in organizations.

The literacy space has become increasingly polarizing since the reading wars began.There are a number of debates and questions that continue, including:Will kids learn to read “naturally”? What did the whole language approach get right, if anything?Is explicit phonics instruction just a pendulum swing (and is focusing on phonics enough)?Are we teaching kids to read too early? When we talk about “early literacy” instruction, what are we actually recommending and how does that look? I invited Jane Gebers, veteran speech-language pathologist and author to episode 157 De Facto Leaders to discuss these questions. I entered the field right around the time the National Reading Panel study was published, so there was a fair amount of research on evidence-based literacy intervention when I started practicing. But when Jane started practicing, much of this research hadn't been done, and she had the experience of watching the fields of education and reading instruction evolve. She was also one of the early adopters of many approaches that are common practice today, and it was an honor to hear about her work. Jane L. Gebers is the author of the popular resource, Books Are for Talking, Too! (Link here: https://www.slpstorytellers.com/2023/09/11/slp-author-book-books-are-for-talking-too-by-jane-gebers/), first published in 1990, and now in its 4th edition as of March 2023. A practicing speech-language pathologist for over 40 years, she has worked in public school, hospital, private, and clinical settings. She has been an adjunct professor at St. Mary's College of California and other universities where she taught Language Development, Assessment, and Intervention courses to students pursuing special education credentials. She currently holds a private practice in Northern California.In this conversation, Jane and I discuss:✅Everyone's talking about “scaffolding”, but what does this word actually mean?✅Reading practices that have stood the test of time, despite attempts to disprove their effectiveness.✅The battle between play-based learning and “sight words”; and how to emphasize the right skills at the right time.✅When building language skills, do we focus on a developmental hierarchy or environmental demands? ✅Mapping language to print symbols and what to address in the early years to set the stage for reading and writing. You can connect with Jane on her website here: https://soundingyourbest.com, and find her book, Books Are for Talking, Too! here: https://www.slpstorytellers.com/2023/09/11/slp-author-book-books-are-for-talking-too-by-jane-gebers/  The following resources were mentioned in this episode:Some of the work done by Dr. Carol Westby, Ph.D. (Link here: https://journals.sagepub.com/doi/10.1177/152574019902100107)The Neuroscience of Reading with Dr. G. Reid. Lyon (Link here: https://irrc.education.uiowa.edu/blog/2023/05/neuroscience-reading-dr-g-reid-lyon)Teachers' Use of Scaffolds within Conversations During Shared Book Reading (Dekshmukh, R.S., Pentimonti, J.M., Zucker, T.A., & Curry, B.) (Link here: https://pubs.asha.org/doi/10.1044/2021_LSHSS-21-00020)In this episode, I mention Language Therapy Advance Foundations, my program that helps SLPs create a system for language therapy. You can learn more about Language Therapy Advance Foundations here:  https://drkarenspeech.com/languagetherapy/I also mentioned The School of Clinical Leadership, my program that helps related service providers guide their teams to support students' executive functioning across the day. This program will help you plan direct therapy, but will also help you lead change management on your team, no matter your job title. You can learn more about the School of Clinical Leadership here: https://drkarendudekbrannan.com/clinicalleadership We're thrilled to be sponsored by IXL. IXL's comprehensive teaching and learning platform for math, language arts, science, and social studies is accelerating achievement in 95 of the top 100 U.S. school districts. Loved by teachers and backed by independent research from Johns Hopkins University, IXL can help you do the following and more:Simplify and streamline technologySave teachers' timeReliably meet Tier 1 standardsImprove student performance on state assessments

I've always made it a priority of mine to find simple yet effective strategies that support literacy teachers in the classroom. One of our main jobs as literacy teachers is to provide our students with the skills to become successful readers and writers. And one way to do that is by giving your students scaffolds to support their literacy growth and development. So, in today's episode, I'm sharing three effective scaffolds that I believe every literacy teacher should be using with their students.Reading scaffolds are necessary tools in the upper elementary classroom. They're designed to support all learners as they develop their literacy skills, which eventually leads to comprehension of a variety of texts. There are three different effective scaffolds that should be staples in your classroom. With each scaffold, I share how it will enhance a student's reading comprehension, a variety of ways to use them, and provide specific examples that you can easily incorporate during your literacy lessons. By using scaffolds in your classroom, you are providing temporary support that helps students accomplish tasks they can't yet manage on their own. And while you might have heard of these effective scaffolds, it's important to know how to successfully use them in order to better support the needs of your students. So, the next time you're asking students to formulate their own ideas, make sure to take advantage of these scaffolds available to you. Show Notes: https://theliteracydive.com/episode166Resources Mentioned:Vocabulary Writing Prompts SampleFREE Context Clues Activity SetReading Comprehension Activity BundleReading Graphic OrganizersReading Comprehension Question RingsReading Skills and Strategies Anchor ChartsSentence Stem Response CardsSentence Stem Anchor ChartsConnect with Me:Join The Daily Writing Disguise Membership hereShop my TpT store hereReceive emails from me hereFollow me on Instagram hereRead my blog posts

It seems every improvement in the quality of life has inadvertently decreased the value of human effort. The only way that marginalized humanity will find meaningful life's is if they become their own inventors and designers of a meaningful existence. No one can do it for them. But maybe we could reward inventiveness instead of hopeless victimhood.

Today we're going to talk about a company that makes scaffolds – not for buildings, but scaffolds that can be implanted into the human body for bones and tissues to grow.  Started in 1992, our guest is Osteopore, an Australian and Singapore based medical technology company commercialising a range of products specifically engineered to facilitate natural bone healing across multiple therapeutic areas.  One of the firm's products included the Osteomesh, which is a mesh-like polymer scaffold that can be implanted into patients' skulls to help them regenerate bone tissues that were taken out in surgical procedures.  Other products include those that can be used for rhinoplasty or a nose implant surgery, as well as those that can be used for jaw surgeries to help people eat and speak normally after injuries.  The firm was listed on the Australian Securities Exchange in September 2019 and had achieved a milestone of 80,000 implants across all major continents in 2022.  But how does Osteopore commercialise its products, and are its patients using its implants also its customers? How does it then assess its relationship with insurers?  Speaking of insurers, Osteopore announced in May last year that the most prominent medical scheme in South Africa, the Discovery Health Medical Scheme (DHMS) has approved the reimbursement of its Osteomesh product. But how big is the South African market to Osteopore and how important is this to the firm's top and bottom lines?  Meanwhile, the firm had in September 2023 signed an agreement with Temasek-linked InnoVentures to commercialise Osteopore's orthopaedic products in China, but how much money does this represent for the company? On Under the Radar, The Evening Runway's finance presenter Chua Tian Tian posed these questions to Dr Lim Jing, Chief Executive Officer and Chief Technology Officer at Osteopore.See omnystudio.com/listener for privacy information.

Continue the journey of building a Next.js application as Aurooba explains how to use Supabase to handle all aspects of user authentication in your app, including user accounts, email notifications, and session data. They also dig into server vs client side differences.A full transcript of the episode is available on the website. Watch the video podcast on YouTube and subscribe to our channel and newsletter to hear about episodes (and more) first!Supabase - https://supabase.com/Supabase SSR - https://supabase.com/docs/guides/auth/server-side/creating-a-clientAuthUI - https://supabase.com/docs/guides/auth/auth-helpers/auth-uiGravity Forms - https://www.gravityforms.com/Next.js App Router - https://nextjs.org/docs/appBrian's website – https://www.briancoords.comAurooba's website – https://aurooba.com (00:00) - S2 E08 (00:08) - Intro Rant (01:43) - Decisions and Planning (04:11) - Today's Topic - Authentication (07:06) - The Supabase Admin UI (09:54) - Authentication UI in Supabase (15:35) - UI versus Config Files or CLIs (17:30) - Frontend Preview - What are we building? (20:38) - AuthUI (23:58) - Our package.json and Cookies (26:32) - Folder Structure (29:17) - Setting up a Supabase Client (35:33) - Submitting Forms to Supabase (38:45) - Session Data and Server-side Console (41:24) - Scaffolds and Boilerplates (42:29) - Flexibility vs Effort (48:40) - Next episode

It's the fourth and final episode of our series exploring Laravel. Brian takes us through the deployment process using Laravel Forge and AWS. Aurooba discusses "modern" WordPress development and how WordPress solutions like SpinupWP compare to tools like Netlify and Forge.A full transcript of the episode is available on the website. Watch the video podcast on YouTube and subscribe to our channel and newsletter to hear about episodes (and more) first!Suggest an episode - https://suggest.viewsource.fm/All the code - https://github.com/viewSourcePodcast/suggest-episodeTailcolor (Tailwind Color Generator) - https://tailcolor.com/Laravel Forge - https://forge.laravel.com/Spinup WP - https://spinupwp.com/Brian's website – https://www.briancoords.comAurooba's website – https://aurooba.com (00:00) - S02E04 - Laravel pt 4 (00:07) - Our Completed Laravel App (02:34) - Tailwind and Colors (04:56) - AlpineJS and Package Bloat (07:57) - Single Page Apps on Laravel (09:43) - Brian's Three Open Terminals (11:52) - Scaffolds and CLIs in WordPress (15:03) - Handling Build Assets in your Deployment (18:36) - Deployment - Forge (and SpinupWP) (24:25) - Connecting AWS to Forge (27:44) - Automated Git Deployments (31:20) - Git vs SFTP in Managed WordPress Hosting (34:33) - Other cool things like queues (37:14) - Final Thoughts

For all the talk of students using Artificial Intelligence to cheat, we can easily miss the reality that A.I. has made differentiated instruction more feasible for educators. In this week’s article and podcast episode, I explore how we can leverage A.I. tools for differentiated instruction.... The post How to Use Generative A.I. to Design Better Scaffolds and Supports appeared first on John Spencer.

Commentary by Dr. Valentin Fuster

Generative A.I. has created some very real challenges with academic integrity. Schools have been scrambling to create systems and policies that address the potential for cheating. In the past, I’ve written about how we might redefine the essay in an age of A.I. or how... The post 5 Ways to Leverage A.I. for Student Supports and Scaffolds appeared first on John Spencer.

"We can rebuild him. We have the technology. We can make him better than he was. Better, stronger, faster." Today we are at the Biologic Scaffolds for Regenerative Medicine Symposium to discuss novel ways to potentially help FSHDers maintain strength and slow down pathology. Additional technology being presented by be applicable to help regain muscle mass after therapy. Joining us is one of the best FSHD advocates around, Emma Weatherley from FSHD Global Research Foundation in Australia. And we drop the newest track from Jaeger the Kid! --- Send in a voice message: https://podcasters.spotify.com/pod/show/peter-l-jones/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.25.532115v1?rss=1 Authors: Saberi, A., Paquola, C., Wagstyl, K., Hettwer, M. D., Bernhardt, B., Eickhoff, S. B., Valk, S. L. Abstract: The human neocortex consists of tangentially organized layers with unique cytoarchitectural properties. These layers show spatial variations in thickness and cytoarchitecture across the neocortex, which is thought to support brain function through enabling targeted corticocortical connections. Here, leveraging maps of the six cortical layers in 3D human brain histology, we aimed to quantitatively characterize the systematic covariation of laminar structure in the cortex and its functional consequences. After correcting for the effect of cortical curvature, we identified a spatial pattern of changes in laminar thickness covariance from lateral frontal to posterior occipital regions, which differentiated the dominance of infra- versus supragranular layer thickness. Corresponding to the laminar regularities of cortical connections along cortical hierarchy, the infragranular-dominant pattern of laminar thickness was associated with higher hierarchical positions of regions, mapped based on resting-state effective connectivity in humans and tract-tracing of structural connections in macaques. Moreover, we show that regions with comparable laminar thickness patterns correspond to inter-regional structural covariance, maturational coupling, and transcriptomic patterning, indicating developmental relevance. In sum, here we characterize the association between organization of laminar thickness and processing hierarchy, anchored in ontogeny. As such, we illustrate how laminar organization may provide a foundational principle ultimately supporting human cognitive functioning. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Hello New York State Apple Growers– and welcome to the scaffolds podcast! This podcast is a reinvention of the scaffolds newsletter, formerly published weekly by Dr. Art Agnello. In this episode we introduce ourselves and tell you what to expect from this show. Cox Lab blog: https://blogs.cornell.edu/coxlab/ Twitter: Kerik Cox & Līga Astra Kalniņa: @fruitpathology Monique Rivera: @moniquejrivera Anna Wallis: @jesuisunanana

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.02.530905v1?rss=1 Authors: Zhang, Y., Seemann, J. Abstract: The mammalian Golgi apparatus is composed of stacks of cisternae that are laterally linked to form a continuous ribbon like structure, but the molecular mechanisms that maintain the Golgi ribbon remain unclear. Here, we show that ribbon formation is mediated by biomolecular condensates of RNA and the Golgi resident protein GM130. We identified GM130 as a membrane-bound RNA binding protein at the Golgi. Acute degradation of either RNA or GM130 in cells disrupted the Golgi ribbon. Under stress conditions, RNA was displaced from GM130 and the ribbon was disjoint, which was restored after cells recovered from stress. When overexpressed in cells, GM130 formed RNA-dependent liquid-like condensates. GM130 contains an intrinsically disordered domain at its N-terminus, which was sufficient to recruit RNA to drive condensate assembly in vitro. Condensates of the N-terminal domain of GM130 and RNA were sufficient to link purified rat liver Golgi membranes which is a reconstruction of aspects of lateral linking of stacks into a ribbon-like structure. Together, these studies reveal that biomolecular condensates of GM130-RNA scaffold the Golgi ribbon. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

This episode is also available as a blog post: http://constructiontales.com/2022/11/03/safety-topic-of-the-day-suspended-scaffolds-in-the-skyline/ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/leslie-m-jasper/support

Join me in welcoming Courtney Morgan to the podcast for a dynamic conversation about the best ways to support your multilingual learners in the general education classroom. She is an ESL teacher, coach, and course creator. She earned degrees in Elementary Education and Multicultural Education, and is also National Board certified in Middle Grades Literacy. After 16 years as an elementary classroom teacher, Courtney shifted into her current teaching role to focus her efforts on supporting multilingual students. She founded The All-Access Classroom to provide training that equips gen. ed. and ESL teachers to make grade-level instruction accessible to multilingual learners. She loves advocating for culturally and linguistically diverse students, and nurturing educators toward equitable practices in the classroom. If you are interested in connecting with Courtney you can find her: Instagram - @theallaccessclassroom Website - https://www.theallaccessclassroom.com/ FREE Resource - A Lesson Plan Template w/ Scaffolds for Multilingual Learners ******************************************************************* Grade Level Book Recommendations - visit https://bookshop.org/shop/CustomTeachingSolutions . Lesson Plan Coaching Call - Click HERE to schedule Activities for creating a welcoming and inclusive class - Buy resources in my TEACHER SHOP Culture-Centered Teacher WORKSHOPS - Click HERE for more information Ready to take action? Grab your FREE "The Ultimate Classroom Diversity Checklist" at https://customteachingsolutions.com/thechecklist Schedule a free DISCOVERY CALL at https://calendly.com/customteachingsolutions/35min Check out The Culture-Centered Teacher Workshops HERE! CONNECT WITH ME: Email - Jocelynn@customteachingsolutions.com LinkedIN - https://www.linkedin.com/company/cts-custom-teaching-solutions/ Instagram - https://www.instagram.com/iteachcustom/ Website - https://customteachingsolutions.com **Custom Teaching Solutions is a affiliate for Bookshop.org, which means we receive a commission on every sale that comes through our link.** --- Support this podcast: https://anchor.fm/jocelynn-hubbard/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.07.506969v1?rss=1 Authors: Siddiqui, A. M., Thiele, F., Stewart, R. N., Rangnick, S., Weiss, G. J., Chen, B. K., Silvernail, J. L., Strickland, T., Nesbitt, J. J., Lim, K., Schwarzbauer, J. E., Schwartz, J., Yaszemski, M. J., Windebank, A. J., Madigan, N. N. Abstract: The spinal cord has poor ability to regenerate after injury, which may be due to cell loss, cyst formation, inflammation, and scarring. A promising approach to treat spinal cord injury (SCI) is the use of biomaterials. We have developed a novel hydrogel scaffold fabricated from oligo(poly(ethylene glycol) fumarate) (OPF) as a 0.08 mm thick sheet containing polymer ridges and a cell-attractive surface chemistry on the other side. When the cells are cultured on OPF with the chemical patterning, the cells attach, align, and deposit ECM along the direction of the pattern. Animals implanted with the rolled scaffold sheets had greater hindlimb recovery compared to the multichannel scaffold control, likely due to the greater number of axons growing across. Inflammation, scarring, and ECM deposits were equal across conditions. Overall, the results suggest that the scaffold sheets promote axon outgrowth that can be guided across the scaffold, thereby promoting hindlimb recovery. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

I know you practice scaffolding when teaching, but do you know you're doing it? What is scaffolding instruction? Scaffolded teaching is when we use various techniques to support students in their learning and then gradually move them toward independence. In this episode, I have nine types of scaffolds for teaching including ways for scaffolding instruction for English language learners.  Listen in to find out more! Don't forget to check out all the resources, and grab the Scaffolds for Instruction Cheat Sheet. It's all in the show notes! TEACH JOYFULLY FB COMMUNITY: https://www.facebook.com/groups/theteachinglab INSTAGRAM: https://www.instagram.com/lisa_j_burns

The article: http://bloggerblaster.blogspot.com/2013/04/the-great-debate-march-to-scaffold.html The Great Inflations vs Deflation Debate between Vox Day and Nate is more relevant today as we see the ideas discussed all those years ago playing out in our everyday lives. Have a listen and see what side you fall on.   Social Media: Social Galactic: https://social.infogalactic.com/ Gab: https://gab.com/upchuckmcduck YouTube: https://www.youtube.com/channel/UCTX1rysLOYH30IKDVRGafSw Bitchute: https://www.bitchute.com/channel/qsBAoGUg2SAk/ Podbean: https://accordingtoandrew.podbean.com Dlive: https://dlive.tv/upchuckmcduck_bear   #economics #debate #Inflationvsdeflation

Download This month, Roger and Mike consider the history and utility of character classes… and do not reveal their True Names.

When I was a new teacher, I had a goal of differentiating instruction for every student. I would provide additional directions, project sheets, tutorials, and small group instruction for any student who needed help. My main focus was on providing the necessary accommodations on IEPs... The post Empowering Students to Self-Select the Scaffolds appeared first on John Spencer.

Underlying assumptions, examples of the ‘happily ever after' mindset, how we're complicit, and what we can do to resist. --- Send in a voice message: https://anchor.fm/raising-luminaries/message

Peter is joined by Andrew Tokely, Horticultural Director, of Kings Seeds. Andrew gives some great tips from how to grow plants from seed, when to plant certain crops to how to protect them. Visit the Kings Seeds website here: http://www.kingsseeds.comYou can write to Peter at thisweekinthegarden@gmail.com See acast.com/privacy for privacy and opt-out information.

Orthopedic Surgeon, Dr. Grant Garcia discusses new tech., hopeful breakthroughs, and exciting possibilities. Topics: Telehealth surge, Cartilage restoration, Biologics, and Fertilized ACL When it comes to our health, we always want the best treatment. Just like we are looking for the best medicine, the best hospitals, the best care, and the best doctors, doctors are on the lookout for new technology, new methods, new equipment that will essentially benefit us… the patient. We discuss things that came faster than expected out of necessity and new technology that is ahead of its time: Telehealth which has increased over 50% in 2020, bringing convenience to so many. Cartilage restoration: Scaffolds to grow cartilage, Arthritis prevention. How do you restore lost cartilage? Biologics: Can the future be as simple as an injection? A procedure that will eliminate the need for surgery. Fertilized ACL: This new procedure was one of the most exciting Dr. Garcia discussed. A technique using a mixture that will fill the tunnels within the knee joint during a traditional ACL reconstruction. This technique also utilizes an innovative concept of internal brace reinforcement to improve the stability of the healing ACL and it will allow the patient to recover in a much quicker time frame. Thank you for listening and have a wonderful holiday season.

Join Dr. Andrew Pelling as he describes some of the challenges his lab is facing developing lab-grown meat.

In this podcast we focus on Rosenshine's Principles of instruction and Step 8 - providing scaffolds for difficult tasks. Helen Morgan and Andy Bridge join us to discuss how important it is for learners to experience "cognitive apprenticeship". They learn how to become an expert thinker with learner skills and the importance as a teacher of knowing when to remove the learning frameworks or scaffolding to allow them to apply their learning themselves. --- Send in a voice message: https://anchor.fm/thirstyscholars/message

On this episode, an electrochemical scaffold that delivers safe doses of hypochlorous acid to treat wound infections in humans, and a method for sampling and monitoring bacteria and viruses or surfaces using plain paper stickers. Links: E-scaffolds on TWiM 143 The EPS matrix (J Bact) Integrated HOCL-producing E-scaffold (AAM) Surface sampling bacteria with paper stickers (AEM) Surface sample viruses with paper stickers (Sci Rep)

This is the LAST episode of the season! We are so excited to bring you the last podcast episode of the season with you with Nina Silver, BFA, RN owner of Silver Solutions Medspa in Pittsfield, MA! A native New Yorker, Nina tells us a fascinating story which starts with her getting into nursing school in the 60's as a way to leave her mother's house, how she found herself building the business of others, and her eventual burnout in the ICU. She went back to her base of knitting and crochetting, you won't guess how a relocation to Western Massachusetts, and her trekking the Appalachian trail led her to go from crochet, to needles, to NEEDLES in a full circle moment. @silversolutionsmedspa www.silversolutionsmedspa.com If you have enjoyed listening to these exciting stories, please leave us a review on Apple! About Nina Silverman, BFA, RN Nina Silver has more than 45 years of nursing experience, along with her eclectic background and a creative drive. She is a registered nurse and a graduate of Parsons School of Design. Nina began her nursing career as an intensive care and coronary care nurse at Jacobi Hospital in the Bronx, NY; in 1991 she joined the medical department at Canyon Ranch in Lenox, MA, as lead nurse educator. In 2005, she joined Mark Hyman, M.D. at the UltraWellness Center in Lenox, MA, specializing in functional medicine wellness coaching. After hiking the Appalachian and Muir trails, Nina decided to merge her interest in art and nursing by gaining certification in non-surgical facial rejuvenation. Nina has completed Master Cosmetic Aesthetic Injection studies, both hands on and didactic, in the United States and abroad, with some of the leaders and innovators in the field of Medical Aesthetic; The Academy for Injection Anatomy (hands on Cadaver course) Chris Surek, MD; Swift Beauty Master Class, Arthur Swift, MD; Tom Van Eijk Academy, Tom van Eijk, MD; Julie Horne Academy in Norway, Julie Horne, RN; American Academy of Facial Esthetics; Medical Aesthetics Institute, Erika Barry, NP; Shino Bay, MD with Galderma; Advanced Injection Techniques-Dr. Thuy Doan, Atlanta, Georgia; Professor Sebastian Cotofana and Dr. Arthur Swift; Injection Anatomy (hands on Cadaver Course) Numerous hands on private trainings sponsored by Allergan, Merz and Galderma. Nina is a member of the International Society of Plastic Surgical and Aesthetic Nurses, and is certified in nutritional intravenous administration by the International IV Nutritional Therapy-Global Education center. She has hundreds of hours of continuing education credits (CEUs) and regularly updates her training in facial aesthetics, HIPAA compliance, electronic medical records (EMR) and practice management expertise. She is the author of Silver Solutions MedSpa, COVID-19 Practice Guideline Directives with references to CDC guidelines. --- Send in a voice message: https://anchor.fm/diamondhands/message

Scaffolds

In this week's episode, we'll be discussing the elements of tyranny and treason as they appear in Shakespeare's play Macbeth as well as modern parallels to the plot and character of Macbeth and the implications of tyranny and treason in the Early Modern Era.  Shakespeare Anyone? is created, written, produced, and hosted by Korey Leigh Smith and Elyse Sharp. Our theme music is "Neverending Minute" by Sounds Like Sander. Works referenced: Coddon, Karin S. “‘Unreal Mockery’: Unreason and the Problem of Spectacle in Macbeth.” ELH, vol. 56, no. 3, 1989, pp. 485–501. JSTOR, www.jstor.org/stable/2873194. Accessed 29 Jan. 2021. Frye, Roland Mushat. “Hitler, Stalin, and Shakespeare's Macbeth: Modern Totalitarianism and Ancient Tyranny.” Proceedings of the American Philosophical Society, vol. 142, no. 1, 1998, pp. 81–109. JSTOR, www.jstor.org/stable/3152266. Accessed 27 Jan. 2021. Lemon, Rebecca. “Scaffolds of Treason in ‘Macbeth.’” Theatre Journal, vol. 54, no. 1, 2002, pp. 25–43. JSTOR, www.jstor.org/stable/25069019. Accessed 24 Jan. 2021. Meron, Theodor. “Crimes and Accountability in Shakespeare.” The American Journal of International Law, vol. 92, no. 1, 1998, pp. 1–40. JSTOR, www.jstor.org/stable/2998059. Accessed 24 Jan. 2021. Mullaney, Steven. “Lying Like Truth: Riddle, Representation and Treason in Renaissance England.” ELH, vol. 47, no. 1, 1980, pp. 32–47. JSTOR, www.jstor.org/stable/2872437. Accessed 31 Jan. 2021. Paul, Richard. Shakespeare Unlimited Podcast, performance by Stephen Greenblatt, et al., episode 100, Folger Shakespeare Library, 12 June 2018. Accessed 25 Jan. 2021. “Sovereignty, Treason Law, and the Political Imagination in Early Modern England.” Treason by Words: Literature, Law, and Rebellion in Shakespeare's England, by Rebecca Lemon, 1st ed., Cornell University Press, ITHACA; LONDON, 2006, pp. 1–22. JSTOR, www.jstor.org/stable/10.7591/j.ctt7zgxv.4. Accessed 25 Jan. 2021. “The Smell of Gunpowder: Macbeth and the Palimpsests of Olfaction.” Untimely Matter in the Time of Shakespeare, by Jonathan Gil Harris, University of Pennsylvania Press, Philadelphia, 2009, pp. 119–140. JSTOR, www.jstor.org/stable/j.ctt3fj17b.10. Accessed 25 Jan. 2021.

Scaffolding is a huge part of what teachers do inside the classroom. We have students that come to us with a wide range of academic and social abilities. Our job is to help them by meeting them where they are at and building them up from there. Tune in to hear about the 5 main scaffolds I use in my math classroom. Click here for the links & resources mentioned in this episode! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/solving-for-the-undefined/support

There's so much to talk about with each play that doesn't fit into the synopsis or into its own episode, so we've decided to cover several topics in this episode. In this episode, we discuss major thematic elements in Shakespeare's Macbeth as well as topics that are usually covered or talked about in reference to this play.  Shakespeare Anyone? is created, written, produced, and hosted by Korey Leigh Smith and Elyse Sharp. Our theme music is "Neverending Minute" by Sounds Like Sander. Additional sound effects from https://www.zapsplat.com Works Referenced: Lemon, Rebecca. “Scaffolds of Treason in ‘Macbeth.’” Theatre Journal, vol. 54, no. 1, 2002, pp. 25–43. JSTOR, www.jstor.org/stable/25069019. Accessed 21 Dec. 2020. LiteraryDevices Editors. Accessed 24 Oct. 2020, from “Themes in Macbeth with Examples and Analysis” https://literarydevices.net/macbeth-themes/ “Macbeth - Themes.” BBC Bitesize, BBC, Accessed 24 Oct. 2020, from www.bbc.co.uk/bitesize/guides/zgv7hyc/revision/1 Marchitello, Howard. “Speed and the Problem of Real Time in ‘Macbeth.’” Shakespeare Quarterly, vol. 64, no. 4, 2013, pp. 425–448., www.jstor.org/stable/24778493. Accessed 21 Dec. 2020. Shakespeare, William. Macbeth. Arden Shakespeare, 2015. SparkNotes Editors. (2005). No Fear Macbeth. Accessed 24 Oct. 2020, from https://www.sparknotes.com/shakespeare/macbeth/

Show Notes: slpnow.com/65

Show Notes: slpnow.com/64

Visit and Subscribe to our other main podcast here...https://cdvideo.org/podcast https://www.podbean.com/podcast-detail/ku3h2-a6b6f/Christadelphians-Talk-Podcast https://podcasts.apple.com/gb/podcast/christadelphians-talk/id1448751691 https://christadelphianstalks.podbean.com/ https://anchor.fm/Christadelphians-Talk other thoughts on our site here https://bibletruthandprophecy.com/category/thought-for-the-day-2/ Part of the Christadelphianvideo.org network Visit our audio site http://christadelphianstalk.com/ #bibletruthandprophecy #christadelphianvideo #truebibleteaching #thegospelmessage #thegospeltruth #firstprinciples #bibletruth #bibleunderstanding #exploringthebible #biblehour #putgodfirst #thechristadelphians #whoarethechristadelphians #hope #salvation #christadelphianvideo #bibletruthandprophecy #christadelphianstalk #hope

Visit and Subscribe to our other main podcast here...https://cdvideo.org/podcast https://www.podbean.com/podcast-detail/ku3h2-a6b6f/Christadelphians-Talk-Podcast https://podcasts.apple.com/gb/podcast/christadelphians-talk/id1448751691 https://christadelphianstalks.podbean.com/ https://anchor.fm/Christadelphians-Talk other thoughts on our site here https://bibletruthandprophecy.com/category/thought-for-the-day-2/ Part of the Christadelphianvideo.org network Visit our audio site http://christadelphianstalk.com/ #bibletruthandprophecy #christadelphianvideo #truebibleteaching #thegospelmessage #thegospeltruth #firstprinciples #bibletruth #bibleunderstanding #exploringthebible #biblehour #putgodfirst #thechristadelphians #whoarethechristadelphians #hope #salvation #christadelphianvideo #bibletruthandprophecy #christadelphianstalk #hope

Dr. Agnello joins us at a time when orchards full of tender young leaves are susceptible to damage by potato leafhopper. He brings an entomology lens to the issue and isn’t fooled by hopperburn. Guest: Dr. Arthur Agnello is the Tree Fruit Extension Entomologist at Cornell AgriTech in Geneva, New York – and you might recognize him as the editor of the Scaffolds newsletter. His interest in insects led him to his longstanding role in research and extension. Website: www.perennia.ca Follow us on Twitter: @nsperennia @nstreefruit Connect with us on: Instagram: @nsperennia Facebook: @nsperennia Music: A Sunny Day by J. Tones Logo Created by: Perennia Food and Agriculture Inc. Email us at: info@perennia.ca

A recent Nature Biotechnology paper from Tony Atala and colleagues at Wake Forest describes the use of bioengineered scaffolds to repair substantial injuries to rabbit uteri, supporting pregnancies and live births. Senior Editor Irene Jarchum discusses this work with Mats Brännström and Mats Hellström, both from Gothenburg University in Sweden. You can read the paper here. See acast.com/privacy for privacy and opt-out information.

In this episode of My Adventures of ESL, you will learn how you can use visuals to support your ELLs.  If you are a new listener to My Adventures in ESL, I would love to hear from you. Please visit email at millie@myadventuresinesl@gmail.com and let me know how I can help you today! In this episode, you will learn: How you can use visuals to support your ELLs Websites that have stunning visuals that accompany your lessons Why you should thoughtfully use visuals with your ELLs Subscribe to My Adventures in ESL to get updates about new episodes and special bonuses. Free Stock Images Websites: Pexels Unsplash Pixabay Join our community on Facebook: https://www.facebook.com/groups/adventuresinesl/

"Dr. Amanda Goodwin":https://peabody.vanderbilt.edu/bio/amanda-goodwin, "Dr. Mark Lewis":https://www.loyola.edu/school-education/faculty/mark-lewis and "Dr. Margarita Gomez Zisselsberger":https://www.loyola.edu/school-education/faculty/margarita-gomez dis

We’re chatting about the game design goals we’ve developed in the course of our research on the main show, Jianghu Hustle. This time we’re talking about how to draw on […]

Richard Kim | Sunday Morning, December 30, 2018

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Richard Kim | Sunday Morning, December 2, 2018

Richard Kim | Sunday Morning, November 25, 2018

June was a big month for me: it was my first time teaching a workshop about the Charlotte Mason method. I was the local hostess for the Charlotte Mason Soirée Summer Mountain Mini, and my topic was scaffolding. I worked out a session description with my co-presenter: With such a rich feast it's easy to … The post Building Without Scaffolds first appeared on Charlotte Mason Poetry.

June was a big month for me: it was my first time teaching a workshop about the Charlotte Mason method. I was the local hostess for the Charlotte Mason Soirée Summer Mountain Mini, and my topic was scaffolding. I worked out a session description with my co-presenter: With such a rich feast it’s easy to …

This week, tougher DNA nanostructures, climate-altering permafrost microbes, and using a robot to discover chemical reactions. See acast.com/privacy for privacy and opt-out information.

In our new podcast, we discuss the life of Stephen Hawking, new studies to extend lifespans, and how scaffolding in cancer vaccines promotes dendritic cell responses. Topics In remembrance of Stephen Hawking SEC press release on Theranos and Elizabeth Holmes Could Rapamycin help humans live longer? High-Fiber Diet Shifts Gut Microbes, Lowering Blood Sugar in Diabetics Personal cancer vaccines show promise Keywords: Stephen Hawking, A Brief History of Time, ALS, Amyotrophic Lateral Sclerosis, Theranos, Elizabeth Holmes, rapaymycin, microbiome, fiber, gut bacteria, type 2 diabetes, cancer vaccine  

Commentary by Dr. Valentin Fuster

On the NB-YAY's Jordan episode the boys finally get new equipment! Matt finds passion in drops. Nicky tells a terrible Rush joke. Jay sticks up for rich white men. Somehow the boys talk about basketball. Warriors comebacks! Who's the Sixers best player? What's the deal with the Clippers? Danny Ainge Flat Earther. Klay loves Scaffolds, and Ray loves Catfish. Follow Us: Twitter: twitter.com/NB_YAY_PODCAST Facebook: www.facebook.com/The-NB-YAY-Podca…763212910551434/ Jay: @Jay_Quiles Nicky: @Nickypalooza Matt: @fattreed Music by: @dixon-hill-beats

Investigates the effectiveness of using scaffolds for case representation on the diagnostic accuracy and efficiency of medical students. Read the accompanying article to this new podcast: http://onlinelibrary.wiley.com/doi/10.1111/medu.13355/full

- We learn why Brits abroad are never “Foreigners”, but always “Expats”  - The Cadbury Easter Egg Hunt Nonsense  - BBC survey on whether people believe certain biblical content literally  - Dan knows what happens after we die - Not!  - We cover the latest on BREXIT  - What is the “theme tune” to your life?  - We respond to challenges from our friends on 'The Godless Rebelution Podcast'   - The recent London Terror Attack  - Apparently it only takes 2 minutes to get terrible information from Google  All of these and many more..    Join in the discussions on our Facebook Page here: https://www.facebook.com/2SkepticalChaps  Link to all our episodes here: http://2skepticalchaps.libsyn.com/podcast  Twitter: @2scpodcast  Email: 2sc.podcast@gmail.com

Dr. Stephen Ellis and Dr. C. Michael Gibson Discuss

Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele Swanson. Right click to download TWiM#143 (32 MB .mp3, 66 minutes). Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a patron of TWiM. Links for this episode Electrochemical scaffold to eliminate persistent biofilms (npj Biofilms Microbiomes) Experimental setup for electrochemical treatment of biofilm (pdf, from article) Acquisition of phage sensitivity by transfer of cell receptors (Cell) Image credit Letters read on TWiM 143 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv 

This session covers fabrication, microstructure and mechanical properties of osteochondral scaffold.

Commentary by Dr. Valentin Fuster

Commentary by Dr. Valentin Fuster

WFIRM talks to Richard Rapoza, PhD about Bioresorbable Vascular Scaffolds.

Background: Tissue engineering approaches for reconstruction of large bone defects are still technically immature, especially in regard to sufficient blood supply. Therefore, the aim of the present study was to investigate the influence of osteogenic stimulation and treatment with VEGF on new bone formation and neovascularization in hMSC-loaded cancellous bone scaffolds in vivo. Methods: Cubic scaffolds were seeded with hMSC and either cultured in stem cell medium or osteogenic stimulation medium. One osteogenically stimulated group was additionally treated with 0.8 mu g VEGF prior to subcutaneous implantation in athymic mice. After 2 and 12 weeks in vivo, constructs and selected organs were harvested for histological and molecular analysis. Results: Histological analysis revealed similar vascularization of the constructs with and without VEGF treatment and absence of new bone formation in any group. Human DNA was detected in all inoculated scaffolds, but a significant decrease in cells was observed after 2 weeks with no further decrease after 12 weeks in vivo. Conclusion: Under the chosen conditions, osteogenic stimulation and treatment with VEGF does not have any influence on the new bone formation and neovascularization in hMSC-seeded cancellous bone scaffolds.

Thu, 2 May 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/15745/ https://edoc.ub.uni-muenchen.de/15745/1/Frankewycz_Borys.pdf Frankewycz, Borys

Microcomputed tomography (mu-CT) is a nondestructive, high-resolution, three-dimensional method of analyzing objects. The aim of this study was to evaluate the feasibility of using mu-CT as a noninvasive method of evaluation for tissue-engineering applications. The polyurethane aortic heart valve scaffold was produced using a spraying technique. Cryopreserved/thawed homograft and biological heart valve were decellularized using a detergent mixture. Human endothelial cells and fibroblasts were derived from saphenous vein segments and were verified by immunocytochemistry. Heart valves were initially seeded with fibroblasts followed by colonization with endothelial cells. Scaffolds were scanned by a mu-CT scanner before and after decellularization as well as after cell seeding. Successful colonization was additionally determined by scanning electron microscopy (SEM) and immunohistochemistry (IHC). Microcomputed tomography accurately visualized the complex geometry of heart valves. Moreover, an increase in the total volume and wall thickness as well as a decrease in total surface was demonstrated after seeding. A confluent cell distribution on the heart valves after seeding was confirmed by SEM and IHC. We conclude that mu-CT is a new promising noninvasive method for qualitative and quantitative analysis of tissue-engineering processes. ASAIO Journal 2013;59:169-177.

Jennifer Quint (Thorax’s journal club editor) talks to Paolo Macchiarini (professor in the Advanced Center for Translational Regenerative Medicine, Karolinska Institutet, Stockholm) about using bioartificial scaffolds to replace complex airway defects.Professor Macchiarini was part of a team who replaced the airway of a tracheal cancer patient with a tailor-made bioartificial scaffold. Their paper was recently published in the Lancet:http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2811%2961715-7/abstract#cor1 ,

Da man sich den negativen Auswirkungen der totalen sowie partiellen Meniskektomie bewusst ist, wird seit mehreren Jahren nach einem geeigneten Ersatzmaterial für geschädigtes Meniskusgewebe gesucht. Bisher konnte allerdings keines der getesteten Materialien das Meniskusgewebe zufriedenstellend ersetzen. Daher war es Ziel der vorliegenden Studie, ein neuartiges Scaffold auf seine Fähigkeit geschädigtes Meniskusgewebe zu ersetzen zu untersuchen. Das getestete Scaffold wurde aus Seidenfibroin, einem Hauptbestandteil der Seide der Seidenspinnerraupe Bombyx mori, hergestellt. Viele Materialien aus Seide konnten bereits in anderen Einsatzgebieten durch ihre gute Biokompatibilität sowie durch hervorragende mechanische Eigenschaften überzeugen. Voruntersuchungen der neuartigen Seidenfibroin-Scaffolds zeigten eine durchschnittliche Porengröße von > 100 μm. Zusätzlich konnten in vitro geeignete mechanische Eigenschaften für den Meniskusersatz sowie eine gute Biokompatibilität der Scaffolds nachgewiesen werden. Daher sollte in der vorliegenden Studie in vivo am Schafmodell getestet werden, ob die Seidenfibroin-Scaffolds auch im Kniegelenk biokompatibel sind, ob sie eine ausreichende mechanische Stabilität aufweisen und ob sie die Entstehung degenerativer Knorpelveränderungen verzögern können. Am medialen Meniskus wurde eine partielle Meniskektomie durchgeführt und die Seidenfibroin-Scaffolds in den Meniskusdefekt implantiert. Es gab zwei Scaffold-Gruppen mit unterschiedlichen Untersuchungszeiträumen. In einer Gruppe betrug die Implantationszeit drei Monate. Das Hauptaugenmerk lag in dieser Gruppe auf möglichen Immunreaktionen gegen das Scaffold. In der anderen Scaffold-Gruppe betrug die Implantationszeit sechs Monate. Als orientierende Vergleichsgruppen wurde eine Tiergruppe shamoperiert, bei einer anderen wurde eine Teilresektion durchgeführt. Der Untersuchungszeitraum dieser beiden Gruppen betrug ebenfalls sechs Monate. Im Vergleich der drei Sechsmonatsgruppen war es möglich die Auswirkungen der Scaffoldimplantation auf die Gelenkgesundheit zu beurteilen. Je Versuchsgruppe wurden 9-10 Tiere operiert. Durch makroskopische, histologische und immunchemische Untersuchungen von Gelenkkapsel, Meniskus und Scaffold sowie Gelenkflüssigkeit wurde die Biokompatibilität der Scaffolds im Kniegelenk überprüft. Die histologischen Untersuchungen der Scaffolds ließen Aussagen über die Bioaktivität und das Einwachsverhalten der Scaffolds zu. Mit makroskopischen, biomechanischen und histologischen Untersuchungsmethoden wurde der Degenerationsgrad des artikulären Knorpels bestimmt, um mögliche chondroprotektive Eigenschaften der Scaffolds zu ermitteln. Zusätzlich wurden Scaffold- und Meniskusproben biomechanisch untersucht. So konnte überprüft werden, ob die Scaffolds vor sowie nach Implantation aus mechanischer Sicht geeignet sind, verletztes Meniskusgewebe adäquat zu ersetzen. Die Ergebnisse dieser Studie zeigen, dass die Seidenfibroin-Scaffolds durchaus Potential für die Anwendung als Meniskusteilersatz haben. Die Biokompatibilität der Scaffolds konnte bestätigt und eine Schädigung des Gelenkknorpels durch die Scaffoldimplantation ausgeschlossen werden. Außerdem scheinen die Scaffolds das Auftreten degenerativer Knorpelveränderungen, wie sie nach partieller Meniskektomie zu beobachten sind, verzögern zu können. Vor Implantation wiesen die Scaffolds eine geringere Steifigkeit auf als das native Meniskusgewebe. Im Laufe der Implantation nahm die Steifigkeit der Scaffolds allerdings zu und unterschied sich nach sechs Monaten nicht mehr signifikant von der Steifigkeit des Meniskus. Auf lange Sicht scheinen die Scaffolds demnach das Meniskusgewebe mechanisch ersetzen zu können. Dies ist besonders wichtig, da die Seidenfibroin-Scaffolds einen dauerhaften Meniskusersatz darstellen und nicht wie andere Materialien einer raschen Resorption und Substitution durch Regenerationsgewebe unterliegen. Allerdings zeigte sich in dieser Studie auch, dass die Fixation der Scaffolds nicht in allen Fällen erfolgreich war. Zudem fand während der Implantationszeit keine Integration der Scaffolds in das Meniskusgewebe statt. Meniskusnah waren zwar einige Scaffoldporen mit Zellen und Bindegewebe gefüllt, eine bindegewebige Verwachsung zwischen Scaffold und Meniskus war hingegen weder nach drei- noch nach sechsmonatiger Implantation zu sehen. Veränderungen der Poreninterkonnektivität, der Porengröße sowie der Fixierbarkeit sind daher vor einem weiteren Einsatz der Scaffolds notwendig. Zudem sollten in einer weiteren in vivo Studie die chondroprotektiven Eigenschaften der Seidenfibroin- Scaffolds über einen längeren Zeitraum untersucht werden.

Dr. Pint's experiences so far have been focused around the synthesis and development of nanoscale materials, and their integration into a broad range of applications, but generally focused around energy devices. He currently June 2012) works as a Research Scientist in the Extreme Technology Research group at Intel Labs in Santa Clara, CA, with a research focus on the development of efficient energy devices. Starting in August 2012, he will be an Assistant Professor of Mechanical Engineering at Vanderbilt University with a research thrust designed around using my expertise to develop efficient and integrated energy devices. His professional long-term passion lies in designing and developing disruptive, transformational earth-abundant and cost-effective energy systems and devices that have promise to displace diminishing fossil fuel resources. Presented January 20, 2012.

Occasioned by the Yale School of Architecture Gallery exhibition, “Ceci n’est pas une reverie: The Architecture of Stanley Tigerman” (curated by Professor Petit) and the gift of the Tigerman archive to Yale University, Professor Petit reviews the work, influence and legacy of Mr. Tigerman (‘60, Arch ‘61).

Next Step #181: A Thanksgiving episode that reveals the 'secret' of Armenian Orthodoxy. A parade opens this message of memories and leads to Thanksgiving "moments." Turning from victim mentality to victor through thanksgiving. A means of survival and growth. A special edition podcast recorded before the dawn.Thanksgiving with Gabriel in Darfur: Truth Be DamnedGreetings from One Genocide to Another: http://youtu.be/weuwKPjvhu0 Song: "Meeting My Past" by Ara Dinkjian (An Armenian in America) Thank You Very Much by the ScaffoldsAni's Bubbles: Thanksgiving MessageProduced by Suzie Shatarevyan for epostle.netLook for The Next Step on blubrry.com

Attorney Paul Meissner informs us of the dangers associated in working with ladders and scaffolds. For more information, visit us at our award winning website at http://www.carlsonmeissner.com/practice-areas/florida-personal-injury-attorneys.aspx or give us a call at 1-800-526-5655

We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph. The data derived from the X-ray computed tomogram were processed by a computer-aided design program to reconstruct a human heart valve 3-dimensionally. Based on this stereolithographic model, a silicone valve model resembling a human aortic valve was generated. By taking advantage of the thermoplastic properties of polyglycolic acid as scaffold material, we molded a 3-dimensional scaffold for tissue engineering of human heart valves. The valve scaffold showed a deviation of only +/- 3-4% in height, length and inner diameter compared with the homograft. The newly developed technique allows fabricating custom-made, patient-specific polymeric cardiovascular scaffolds for tissue engineering without requiring any suture materials. Copyright (c) 2008 S. Karger AG, Basel

A Limited Fork sound poam

This study investigates collaborative learning of small groups via text-based com-puter-mediated communication. We analyzed how two approaches to pre-structure communication influence participation, individual knowledge transfer, the conver-gence of participation and the convergence of knowledge among learning partners. We varied the factor "scripted cooperation" and the factor "scaffolding" in a 2x2-design. 105 university students of Pedagogy participated. Results show that scrip-ted cooperation was most and scaffolding least beneficial to individual transfer, knowledge convergence and participation in comparison to open discourse