Podcasts about permitted

Avodah Zara 49 : Marc Chipkin : 2025-08-06 Permitted and forbidden causes combining to produce a result. Avoiding benefit from avodah zarah by throwing away its value. The shavings of an asheirah tree.

A new mishnah! (from the previous daf) Permitted foods, for a change, including milk that was milked by a non-Jew, who was watched by a Jew, and certain fishes, and more. Plus, a deep dive into fish and roe (fish eggs), vs. other seafood, which birth their young (and are not kosher). But some non-kosher fish also lay eggs. Also, the need for experts who were able to determine whether a given fish and its roe were kosher or not. Plus, a story about Rabbi Yehudah HaNasi, his stomach ache, and its cure in non-Jewishly-made 70-year-old non-Jewish apple wine.

Source material: https://drive.google.com/file/d/1i5ZNDrth2okF7ACLBvKafjGgOKBU74sm/view?usp=drive_link

Nazi hikers were questions by the police in the Swiss Alps. Doctors played musical bingo during a surgery in which the patient perished. A New York law firm fired an intern for biting coworkers. // Weird AF News is the only daily weird news podcast in the world. Weird news 5 days/week and on Friday it's only Floridaman. SUPPORT by joining the Weird AF News Patreon http://patreon.com/weirdafnews - OR buy Jonesy a coffee at http://buymeacoffee.com/funnyjones Buy MERCH: https://weirdafnews.merchmake.com/ - Check out the official website https://WeirdAFnews.com and FOLLOW host Jonesy at http://instagram.com/funnyjones

### Brandon Block Party Turns Deadly: FAFO Champ Ryan Mosley Busted for Murder! In a hard-hitting FAFO Championship segment, Clay Edwards crowns Ryan Mosley (31) as the "f'ed around and found out" winner for a fatal shooting at a city-sanctioned block party on June 21, 2025, in Brandon's 200 block of Mary Miles Drive. Permitted by Mayor Butch Lee's office (with city floodlights & barricades), the event erupts in gunfire – two males shot, transported privately to Merit Health Rankin. Victim Collier succumbs; the other survives. Mosley, also wounded, arrested post-hospital for 1st-degree murder & felon w/ firearm ($1M bond). Shoutout to Brandon PD & Chief Joseph French: "Dedication to justice – great team keeping neighborhoods safe!" Clay questions permitting without security: "High-risk; require overtime cops & liability insurance. Pandering for votes? Lowering standards leads to this – don't South Jackson my Brandon!" Rant on avoiding sketchy events: "If you need a gun, don't go!" Ties to cultural rot & reevaluating block-party policies. 

Mining Stock Daily introduces the Dome Mountain Gold Mine in British Columbia, spearheaded by Blue Lagoon Resources. CEO Rana Vig shares insights into the project's journey from acquisition to imminent production, highlighting the strategic partnerships and community engagement that have paved the way for success. Rana describes how this high-grade gold vein system, with its promising 15-year mine life, is set to transform the landscape of mining in the region. 

1 section- time at which the chametz becomes prohibited in benefit with chiddushim and debate about methods of destruction

1 section- time at which the chametz becomes prohibited in benefit with chiddushim and debate about methods of destruction

Ask A Question: saythatpodcast@gmail.com Intro and a mystery sign emergency (00:00-20:11) Jesus talks about not praying in public like the hypocrites. What does that mean for praying in front of a church? Or famous people having pictures taken of them praying? Or non-famous people, like wedding pictures of people praying over the couple? Is that a sin? Just weird? (20:20-39:12) I know it is not my place to judge anyone else's salvation. But, At some point, people who believe things like God loves rich people more than poor people or God wants us to treat immigrants badly are just not Christian by any definition that I recognize. How do I acknowledge that without judging? (39:18-01:00:06) A lot of talk about being honest with God is about being angry at Him? What about being disappointed, or sad about things he has done, are those okay feelings to have? (01:00:09-01:15:12) Closing Song: Psalm 147:3 (The Poolhouse Guru)

The Halacha below was derived from multiple classes orated by Rabbi Eli Mansour in the Bekiim B'Halacha series. Click on any of the dates below to hear the original audio files, which are the sources for today's Halacha below. 04/23/25 ; 04/29/25 ; 05/05/25 ; 05/18/25 Can One Wear Tefillin on Top of a Hat, Bandage, or Scalp Cover—And When Is This Permitted? Tefillin Shel Rosh must sit directly on the head, without any barrier (hatssitsa) between the box or straps and the skin. But what if a person is cold, recovering from surgery, or must wear a bandage or other covering on the scalp? Are there exceptions in such cases? Must the Tefillin Shel Rosh Touch the Head Directly? Yes. According to the Shulhan Aruch (Orah Haim 27:4), the Tefillin Shel Rosh must be placed directly on the skull, with no hat, yarmulke, or material in between. This is derived from the word "bein einecha"—"between your eyes"—which the Rabbis understood as referring to a specific location on the skull that must be directly under the Tefillin. The box of the Shel Rosh (the bayit) and the knot at the back (the kesher) must both rest directly on the skin. The halacha considers anything in between to be a hatssitsa, which invalidates the Misva. What If There's a Medical Condition or Bandage? If someone has a medical bandage, stitches, wound, or skin sensitivity, and it is difficult to wear Tefillin directly on the scalp, he may still put on the Shel Rosh over the bandage—without a Beracha. This is a ruling based on the principle of safek Berachot lehakel: when there's doubt about whether a Beracha is appropriate, we refrain from reciting it. Hacham Ovadia Yosef writes that one may rely on the view of the Rashba, who held that the Beracha is still valid even if the Tefillin rests on a hat or covering. However, since most Poskim disagree, the person should wear the Tefillin without a Beracha. Does This Apply to Cold Weather or Wind? Yes, but only under specific circumstances. If a person feels unwell or is sensitive to the cold and is unable to remove his hat, he may place the Tefillin on top of a thin head covering. Again, he should do so without a Beracha. If the person can tolerate it, even for just a few moments, it is best to briefly remove the hat or covering, place the Tefillin correctly, and then replace the covering in a way that doesn't interfere with the box or the straps. Some wool hats or fitted caps can be gently pulled over the bayit once it's already in place. Can Women Assist Someone with Head Tefillin Placement in These Cases? Yes. In cases where someone is physically unable to reach the correct spot—due to illness, age, or surgery—others may assist with positioning the Shel Rosh. The Halacha permits assistance by another Jew, even a woman, when the individual is still fulfilling the Misva himself. The helper merely aids in placing the Tefillin properly. What About Wigs or Toupees? A wig is considered a hatssitsa. If the wig is removable, the person must take it off before donning the Tefillin. If it cannot be removed or causes embarrassment, and it is worn tightly and habitually, some authorities may allow the Tefillin to be placed over it without a Beracha, similar to the case of a medical wrap. Summary - Tefillin Shel Rosh must touch the scalp directly—no hat or cloth may intervene. - If this is not possible due to medical or health reasons, one may place it over a covering without a Beracha. - This leniency applies to bandages, surgical dressings, or cold weather gear only when absolutely necessary. - Wigs are generally a hatssitsa, unless removal is not practical. - Whenever possible, the Tefillin should be worn in the standard way, even for a short time, to fulfill the Misva with a Beracha.

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In this episode, we explore the halachic principles surrounding temporary structures on Shabbat—specifically tents, curtains, and bed canopies. The discussion focuses on when it is permitted to erect or dismantle these structures, how elements like cords and a handbreadth-sized "roof" factor into permissibility, and whether everyday items like blankets can pose a halachic issue. Clear guidance is drawn from the Mishna Berura, Shulchan Aruch, and other key sources, offering practical insight into common Shabbat questions.

Can you visit Israel during a war due to the danger? How do hospitals deal with patients during missile alerts? Is there an obligation to go to a bomb shelter while you are learning Torah? Is it permitted to travel to and from Israel via Egypt, Jordan or Cyprus when Ben Gurion Airport is closed? Can someone in Yerushalayim travel to Bnei Brak or Tel Aviv where it's more dangerous? Host: Ari Wasserman, author of the newly published, revised and expanded book Making it Work, on workplace challenges and Halachic Q & A on the Job You can order "Halachic Q & A on the Job” at https://mosaicapress.com/product/halachic-q-a-on-the-job/ with Rabbi Anthony Manning – Jewish educator, author and speaker – 12:22 with Dov Kram – general contractor and project manager in Israel – 39:15 with Rabbi Yossi Sprung – Rav of Shaare Zedek Medical Center and  Rosh Beis Medresh, Beis Medrash Govoha for Medical Halacha – 49:31 Conclusions and takeaways – 1:21:46 מראי מקומות   

New data shows rents rise slower in areas of San Diego where more homes are permitted. Then, the city of San Diego is considering increasing the minimum wage for hospitality workers. Also, we evaluate some of the claims made by candidates in the San Diego County District 1 election. Finally, local researchers say more baby boomers are consuming cannabis

Interview with Barry O'Shea, CEO, Highland CopperRecording date: 18th June, 2025Highland Copper Company emerges as one of the most compelling investment opportunities in the U.S. critical minerals sector, operating a fully permitted copper development project positioned to address America's growing strategic mineral shortage. Led by CEO Barry O'Shea, who brings 15 years of mining finance expertise including successful value creation at Fiore Gold, the company's Copperwood project in Michigan's Upper Peninsula represents a rare construction-ready copper mine in domestic U.S. markets.The project's economics demonstrate exceptional leverage to copper prices. At $4 per pound copper, Copperwood delivers $170 million NPV with 18% IRR, but at $5 copper, NPV jumps dramatically to $510 million—a 300% increase from just 25% higher copper prices. This sensitivity positions Highland Copper to benefit significantly from ongoing copper market tightness and the metal's critical role in electrification and defense applications.Highland Copper's competitive advantage extends beyond economics to its regulatory position. Unlike competitors facing years of permitting uncertainty, Copperwood holds all seven required Michigan state permits and operates on private land, eliminating federal NEPA process delays. This fully permitted status, combined with 22 formal government resolutions of support and a proposed $50 million state grant, creates unprecedented government backing for a private mining venture.The company's capital structure reflects institutional confidence, anchored by Orion Mine Finance's 28% equity stake, which provides both patient capital and a clear path to construction financing. With targeting a construction decision by first half 2026 and an 11-year initial mine life producing 30,000 tons of copper annually, Highland Copper addresses the urgent need for domestic copper production.As O'Shea emphasizes, "What the US needs now is projects that can be built and not ones that are sitting at first drill hole." This construction-ready status positions Highland Copper as a strategic play on America's industrial renaissance and energy security objectives, making it a standout opportunity in the critical minerals space.Learn more: https://www.cruxinvestor.com/companies/highland-copperSign up for Crux Investor: https://cruxinvestor.com

The rift between the hawkish voices in the Trump administration and DNI Tulsi Gabbard becomes more apparent after Tulsi's exclusion from Trump's Camp David meeting on Iran. What does her future look like within MAGA? Plus: outrage erupts after Iran strikes a hospital in Israel, yet there is little concern over the several hospitals in Gaza that have been destroyed by Israel.  ----------------------------------- Watch full episodes on Rumble, streamed LIVE 7pm ET. Become part of our Locals community Follow System Update:  Twitter Instagram TikTok Facebook      

Luke Norman, Co-Founder and Chairman of US Gold Corp. (NSADAQ:USAU), joins me to reintroduce the value proposition at the Company's flagship, fully-permitted, and shovel-ready CK Gold-Copper Project in Wyoming, the upcoming catalysts, as well as the significant underappreciated value in their secondary Keystone Gold Project in Nevada.   We start by discussing the 1.6 million gold equivalent ounces of resources, broken down into roughly 1 million ounces of gold and 260 million pounds of copper.  They company is in the process of working  towards their Definitive Feasibility Study where they'll demonstrate to the market improved metrics over the prior versions of their Pre-Feasibility Study (PFS).   We discussed though that based on the existing PFS, using just a $4.30 copper price and $2,500 gold price that the after-tax NPV of the project is $532Million with a 39.4% IRR and a payback period of 1.63 years.  As it stands today there is a10-year mine life, projecting to produce an average of 110,000 gold equivalent ounces per annum, with an All-In Sustaining Cost of $937, an upfront capex of $277Million, and sustaining capital of $13Million per year.   Those metrics will all be getting updated in the DFS due out in Q4.   Additionally, Luke highlights how their granite is actually very high spec, and a saleable product with several interested parties interested in off-taking this material, so that is even more considerable value above and beyond the gold and copper resources.   One other unique feature of the project that we discuss, is that after the pit has been mined out, as part of the mine closure process, it will be turned into a large water storage facility for the surrounding area and state park, and keeps them from having to build larger dams to flood that surrounding area.   Next we shift over the value potential of their Keystone Gold Project  in Nevada, which is located along the same mineral trend as Nevada Gold Mine's Cortez Complex.   This property has many similarities to this well-endowed district, with the same kind of pathfinder arsenic mineralization with the gold found in these Carlin-gold type systems, as well as the Wenban rock formations.  Luke was very constructive of their potential to unlock more value in the project.   Wrapping up we discussed the key members of the management team and board of directors, the financial health of the company, the tight share structure, solid analyst coverage, plan to work on the capex financing, and other key upcoming catalysts over the balance of the next several months.     If you have any follow up questions for Luke regarding US Gold Corp, then please email me at Shad@kereport.com.     Click here to follow the most recent news from US Gold Corp  

Jamie Levy, President and CEO of Generation Mining Limited (TSX:GENM, OTCQB: GENMF), joins me for an update on their fully-permitted and shovel-ready Marathon Copper-Palladium Project in Northwestern  Ontario.  We talk resources, key metrics from the Feasibility Study, options for the upcoming mine financing, and the potential for funding support from the province of Ontario.   We start off talking about he robust resources at Marathon with 1.1 billion lbs of copper, ~4 million ounces of palladium, and 1.3 million ounces of platinum, with some additional co-credits from gold and silver.   Jamie highlights the importance of developing domestic sources of these strategic metals in Canada, and the interest from the provincial and federal governments on expediting the construction of new mines and sources of supply in country.   The Feasibility Study estimated a Net Present Value (using a 6% discount rate) of C$1.07 billion, an Internal Rate of Return of 28%, and a 1.9-year payback based on the 3-yr trailing average metal prices at the effective date of the Technical Report. Over the anticipated 13-year mine life, the Marathon Project is expected to produce 2,161,000 ounces of palladium, 532 million lbs of copper, 488,000 ounces of platinum, 160,000 ounces of gold and 3,051,000 ounces of silver in payable metals.    We discuss the capital stack coming together starting off with the Wheaton Precious Metals stream, which consisted of an early deposit of $40 million (received) and then an upcoming $200M construction payment for 100% gold and 22% platinum production. Endeavour Financing has also helped set up a mandate letter for banking syndicate of Export Development Canada, ING Capital LLC and Societe Generale to arrange a Senior Secured Project Finance Facility of up to $540M. Conditional on final diligence and debt capacity.  Additionally, there are ongoing discussions for $200M of deeply subordinated debt, and the potential for government grants.   Wrapping up we discussed the experience of the team in developing and building prior mines, and why they'd prefer to build Marathon internally, but are still open to the options of JV partners or a project scale if it was the best value creation for shareholders.     If you have any questions for Jamie regarding Generation Mining, then please email those in to me at Shad@kereport.com.    Click here to follow the latest news from Generation Mining

In today's episode of Exploring Mining Podcast, Host Cali Van Zant speaks with Paul Mastantuono, CEO & Director of ESGold Corp. (CSE: ESAU | OTCQB: ESAUF | FSE: Z7D) A fully permitted, pre-production resource company leading innovation in clean mining and sustainable exploration.We dive into ESGold's strategic shift toward focusing on high-value, low-cost resources like tailings and surface ore bodies at their flagship Montauban property, located 80 kilometers west of Quebec City. We also explore ESGold's founding in 2010, driven by a vision to fast-track production and deliver shareholder value by moving away from the traditional drilling-heavy model of junior mining.Additionally, we touch on the company's share structure and newest key members to the team.About ESGold Corp. ESGold Corp. (CSE: ESAU | OTCQB: ESAUF | FSE: Z7D) is a fully permitted, pre-production resource company at the forefront of clean mining and exploration innovation. With proven expertise in Quebec, the Company is advancing its projects toward production and feasibility while delivering long-term value through sustainable resource recovery and exploration. ESGold's flagship Montauban property, located 80 kilometers west of Quebec City, serves as a model for responsible mining practices, combining near-term production with district-scale discovery potential.For more information, please contact ESGold Corp. at +1-888-370-1059 or visit esgold.com for additional resources, including a French version of this press release, past news releases, a 3D model of the Montauban processing plant, media interviews, and opinion-editorial pieces.Disclaimer/Disclosure: This podcast and content featuring ESGold Corp. are paid for content at Investorideas.com, part of a monthly marketing mining stock showcase (payment disclosure). Our site does not make recommendations for purchases or sale of stocks, services or products. Nothing on our sites should be construed as an offer or solicitation to buy or sell products or securities. All investing involves risk and possible losses. This site is currently compensated for news publication and distribution, social media and marketing, content creation and more. Disclosure is posted for each compensated news release, content published /created if required but otherwise the news was not compensated for and was published for the sole interest of our readers and followers. Contact management and IR of each company directly regarding specific questions. More disclaimer info: https://www.investorideas.com/About/Disclaimer.aspLearn more about publishing your news release and our other news services on the Investorideas.com newswire https://www.investorideas.com/News-Upload/ Global investors must adhere to regulations of each country. Please read Investorideas.com privacy policy: https://www.investorideas.com/About/Private_Policy.aspFollow us on X @investorideas @Exploringmining Follow us on Facebook https://www.facebook.com/Investorideas Follow us on YouTube https://www.youtube.com/c/InvestorideasContact Investorideas.com to be a guest or sponsor this podcast 800-665-0411 

Interview with Sean Roosen, Founder & CEO of Osisko Development Corp.Our previous interview: https://www.cruxinvestor.com/posts/osisko-development-tsxvodv-permitted-cariboo-project-towards-becoming-500000-oz-gold-camp-6379Recording date: 4th June 2025Osisko Development Corporation presents a compelling investment opportunity as one of only two fully permitted gold mines in Canada, positioning the company to capitalize on gold's strategic renaissance while benefiting from exceptional project economics and proven management execution.Project FundamentalsThe Cariboo Gold project in British Columbia represents a rare permitted asset in an increasingly constrained development environment. With construction permits secured in under 5 years compared to the industry average of 14 years, Osisko Development has overcome the primary hurdle facing gold developers. The project targets initial production of 200,000 ounces annually from a 5,000 ton per day operation, requiring $650 million capex versus competitors demanding $6.5 billion.The deposit contains 2 million ounces in reserves at 3.8 grams per ton, significantly exceeding comparable Canadian operations like Alamos' Young Davidson mine at 2.2 g/t and Agnico's Goldex at 1.52 grams. Cariboo's additional resources include 1.6 million ounces measured and indicated plus 1.8 million ounces inferred, spanning a 4.4 kilometer strike within a 50 kilometer mineralized trend under company control.Superior EconomicsProduction economics appear robust with costs targeting $1,157 per ounce, generating substantial margins at current gold prices exceeding $2,400. At these levels, the operation projects annual free cash flow of $457 million, providing significant financial flexibility.Construction activities are underway with 1,200 meters of underground development completed and critical equipment secured. The company has invested $700 million to date with over 700,000 meters of drilling, demonstrating development thoroughness that reduces execution risk.Proven Management Track RecordCEO Sean Roosen brings exceptional credibility through his track record building Canadian Malartic, which became Canada's largest gold mine. After selling that asset for $4.1 billion in 2014, now the  mine represents $22 billion of Agnico Eagle's valuation. This value creation extends across the Osisko platform, including Osisko Mining's $2.16 billion sale to Gold Fields.Scaling and M&A PotentialThe project offers significant expansion potential through phased development, potentially reaching 500,000 ounces annually. Management envisions scaling from 5,000 to 15,000 tons per day processing rates, supported by the deposit's exceptional size. As Roosen noted, "You could put all three of those mines [Young Davidson, Goldex, and Landronne] in the footprint of this deposit and still have room for one more Young Davidson."The company operates with a $375 million market capitalization and benefits from strategic shareholder support, with investors holding 24% and 9.9% stakes respectively. Industry consolidation trends favor quality assets like Cariboo Gold, with management noting that "If I look at all the top 10 M&A ideas that come out, ODV is always on the list."Near-Term CatalystsProject financing announcements expected within two months should significantly de-risk the investment while potentially providing share price catalysts. The G Mining precedent, which achieved a $4.3 billion valuation after successful project development, demonstrates potential upside for executed development stories.Osisko Development represents leveraged exposure to gold's strategic importance through a rare permitted asset with superior economics, proven management, and multiple value creation pathways.View Osisko Development's company profile: https://www.cruxinvestor.com/companies/osisko-developmentSign up for Crux Investor: https://cruxinvestor.com

Dr. John Sweetenham shares highlights from Day 5 of the 2025 ASCO Annual Meeting, including data from large trials in advanced malignant melanoma and mCSPC plus a new approach to first-line treatment for patients with multiple myeloma who are not transplant eligible. Transcript Hello, I'm Dr. John Sweetenham, the host of the ASCO Daily News Podcast, with my takeaways on selected abstracts from Day 5 of the 2025 ASCO Annual Meeting. My disclosures are available in the transcript of this episode. The selected abstracts from this final day of ASCO25 include important new data from large, randomized trials in patients with advanced malignant melanoma and patients with metastatic castration-sensitive prostate cancer, as well as a new approach to the first-line treatment of patients with multiple myeloma who are not transplant eligible.  Starting with LBA9500, this study was conducted in patients with completely resected stage III or IV malignant melanoma and compared the combination of relatlimab plus nivolumab versus nivolumab alone in this population. The study, named the RELATIVITY-098 trial, was presented by Dr. Georgina Long from the University of Sydney, Australia. In her introduction to the study, Dr. Long explained that the current standard of care for adjuvant therapy of resected stage III/IV melanoma is with PD-1 monotherapy with nivolumab, but that about 50% of patients will suffer from a subsequent relapse. In the first-line setting in patients with advanced or unresectable melanoma, the combination of nivolumab with the LAG-3 inhibitor, relatlimab, has been previously shown to improve progression-free survival in the RELATIVITY-047 trial. The current study evaluated this same combination in the adjuvant setting. More than 1,000 patients from 24 countries were randomized to receive either nivolumab alone (546 patients) or the combination of nivolumab with relatlimab (547 patients). Both treatments were given for a maximum of 1 year or until progression of disease, unacceptable toxicity, withdrawal, or death. Various biomarker studies were also undertaken including LAG-3 and PD-1 expression on CD8-positive T cells. The primary endpoint of the study was relapse-free survival, and Dr. Long reported that this was the same in both arms of the study. For example, at 24 months, the relapse-free survival was 64% in the monotherapy arm compared with 62% in the combination arm. The hazard ratio was 1.01 and the P value was 0.928. Metastasis-free survival was also identical in both arms. No benefit was observed for the combination in any of the prespecified subgroups. No new toxicity signals emerged compared with the RELATIVITY-047 trial. Interestingly, the baseline surface expression of LAG-3 and co-expression of LAG-3 and PD-1 on CD8 T cells in the 098 adjuvant trial were lower than in the 047 advanced disease trial, perhaps explaining why the combination did not confer benefit over nivo alone in the adjuvant setting. This is an important result, demonstrating that results from one clinical setting cannot always be extrapolated to another. Although the combination has gained some use in the adjuvant setting, this study clearly demonstrates that more drug in this situation is no better and that monotherapy remains the current standard of care. Results from the AMPLITUDE trial for patients with metastatic castration-sensitive prostate cancer with alterations in homologous recombination repair (HRR) genes, in LBA5006, were presented today by Dr. Gerhardt Attard from University College London, UK. This international, multicenter study evaluated the combination of the selective PARP inhibitor, niraparib, in combination with abiraterone acetate and prednisone. The same combination has been previously shown to improve outcomes in castration-resistant metastatic prostate cancer harboring BRCA mutations in the MAGNITUDE study. The current trial included patients with castration-sensitive disease with HRR mutations including BRCA1/2. Six hundred and ninety-six patients were randomized between niraparib, abiraterone, and prednisone plus androgen deprivation therapy, or the same combination with placebo instead of niraparib. Permitted prior therapies included no more than 6 months of prior androgen deprivation therapy and the use of docetaxel, or prior palliative radiation therapy. The primary endpoint of the study was radiographic relapse-free survival. Dr. Attard reported that the risk for radiographic progression-free survival in the whole population was significantly reduced by 37% with niraparib and abiraterone acetate plus prednisone compared with the placebo arm. The radiographic progression-free survival risk reduction with niraparib in the prespecified BRCA1/2 subgroup was 48% and reached statistical significance compared with the placebo arm. The secondary endpoint of time to symptomatic progression was also improved with niraparib in the HRR population and the BRCA1/2 subgroup. There was a trend for overall survival favoring the niraparib combination. However, the overall survival data were immature at this first interim analysis and did not yet reach statistical significance. No new safety concerns emerged with the toxicity data consistent with the MAGNITUDE study. Less than 5% more of the patients on the experimental arm discontinued treatment in comparison to the control arm. The authors conclude that the AMPLITUDE study results support the use of niraparib, abiraterone, and prednisone as a new treatment option for patients with metastatic castration- sensitive prostate cancer and BRCA and homologous recombination repair gene alterations. The results certainly support this conclusion and are potentially practice-changing. Turning to hematologic malignancies, my final selection from today's presentations is Abstract 7504, presented by Dr. Hang Quach from St Vincent's Hospital, Melbourne, Australia, and describes a novel combination of elranatamab, daratumumab, and lenalidomide in patients with newly diagnosed multiple myeloma who are not transplant-eligible – the so-called MagnetisMM-6 trial part 1. Elranatamab is a novel bispecific T-cell engaging antibody directed against BCMA and CD3, which has previously been approved for certain patients with relapsed and refractory multiple myeloma. In the present study, this was combined with lenalidomide and daratumumab in newly diagnosed patients. The report today describes the dose-finding phase of this study, which was part 1, specifically addressing so-called dose level ‘G', comprising elranatamab 76mg subcutaneously every 4 weeks plus daratumumab 1800mg subcutaneously and lenalidomide 25mg given orally. Thirty-seven patients were entered at this dose level, of whom 32 were on treatment at the time of analysis. Early response data show an overall response rate of 97.3%. With median follow up of 7.9 months, the current CR rate is 27% with a VGPR rate of almost 68%. The most frequent toxicities were hematologic, with neutropenia observed in 75%. Some cytokine release syndrome was observed in about 60% of patients, but none was greater than grade 2. The authors conclude that this combination is active in untreated multiple myeloma, with manageable toxicity and evidence of responses which appear to deepen over time. The dose-finding component of this trial is continuing and will subsequently progress into a phase 3 trial based on the data from the current study. This will compare daratumumab plus lenalidomide with the same combination plus elranatamab in previously untreated patients. That concludes our special coverage from the 2025 ASCO Annual Meeting. Thanks for listening and we hope you have enjoyed listening to our top takeaways from ASCO25. If you value the insights that you hear on the ASCO Daily News Podcast, please remember to rate, review, and subscribe wherever you get your podcasts. Disclaimer:  The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  Find out more about today's speaker:    Dr. John Sweetenham    Follow ASCO on social media:     @ASCO on Twitter    @ASCO on Bluesky    ASCO on Facebook    ASCO on LinkedIn     Disclosures:   Dr. John Sweetenham:    No relationships to disclose

Do you feel like you're constantly chasing the next goal, the next achievement, the next “perfect” version of yourself? This episode permits you to breathe. Dr. Kelly O. breaks down five powerful strategies to overcome exhaustion, release perfectionism, and honor your humanity. From spiritual alignment to practical routines, get the tools you need to work smarter—not harder—while reclaiming your joy and vitality.Share, like, and follow this Vivalife SPF ME podcast on Spotify/Amazon,/Google platformsVivaLife SPF ME • A podcast on Spotify for PodcastersSubscribe to our YouTube: https://youtube.com/@vivalifehealthhub8261?si=zLFMLAZ126ss6qyOClick the link below to join our mailing list, events, and experienceshttps://vivalifespfme.com/dr-kelly-o-md-linktreeBook Dr. Kelly O., MD: https://vivalifespfme.com/speakerBuy your journal: https://vivalifespfme.myshopify.com/products/vivalife-spf-me-journal We can't be erased, T-shirt & Hat! https://vivalifespfme.myshopify.com/products/we-cant-be-erased-tshirt #Affirmation #365DaysofAffirmation #VivalifeSPFMEPodcast #VivalifeSPFME #VivalifeHealthHUB #DrKellyOMD

Minaurum Gold co-founder & CEO Darrell Rader discusses the company's Alamos Silver project, its grade and potential for significant expansion. 0:00 Intro0:55 Company Background2:10 How Alamos Project Stands Out5:50 Value of Alamos Being Fully Permitted9:10 Grade11:55 Width of Veins15:00 Targets to Get to 100M oz17:45 Pace of Drilling Now vs. Previous Years20:00 Cost of Drilling20:40 Rising Interest from Investment Banks23:00 What are the Risks?24:25 Path Forward26:00 Investing in Silver Stocks

In this episode, we delve into the concept of indirect movement on Shabbat — when and how it's permissible to move otherwise prohibited items to access permitted ones. We explore practical examples like retrieving buried produce and shifting straw on beds, emphasizing the halachic nuances around intention, location, and method of movement.

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We would love to pray for you! Please send us your request here. --------Thank you for listening! Your support of Joni and Friends helps make this show possible. Joni and Friends envisions a world where every person with a disability finds hope, dignity, and their place in the body of Christ. Become part of the global movement today at www.joniandfriends.org. Find more encouragement on Instagram, TikTok, Facebook, and YouTube.

Nicola Mining (TSX.V: NIM | FSE: HLIA | OTCQB: HUSIF) is reshaping what it means to be a junior miner. President, CEO, & Director Peter Espig joins to discuss their fully permitted mill, strategic partnerships, and diverse British Columbia-based projects—the Dominion Creek Project, their partnership with Blue Lagoon Resources, and high-grade copper and silver assets. He also covers the company's community-driven environmental approach and key milestones ahead, including the start of full-time operations and the launch of gold, silver, and copper production beginning mid-2025.Learn more about Nicola Mining: https://nicolamining.com/Catch Nicola Mining at the Commodities Global Expo 2025, taking place on May 11–13 at the Four Seasons in Fort Lauderdale, Florida. Secure your spot and connect with Nicola Mining: https://topshelf-partners.com/Watch the full YouTube interview here: https://youtu.be/vZ29CpZjI2I And follow us to stay updated: https://www.youtube.com/@GlobalOneMedia?sub_confirmation=1

We continue learning Hilchos Sefirah discussing the Time Period beginning Sunday Night Monday Hod the 5th week of Sefirah climaxing with Hod of Hod Lag Bomer. The Halacha of making weddings and haircuts Permitted this special day and most follow the custom leading up to Shavuot to end the Hilchos Mourning of the Sefirah. We mentioned Hilchos Shavuot and began the extensive learning of Hilchos Yom tov. The Inner message we began and end with is Learning Torah whenever including Weekly in the Office leads straight away to increased Inner Peace & Joy. Simchat Yom Tov Ochel Nefesh will be a huge Avodah going ahead... will continue hopefully from the Office in London...BH Cover Photo is the Tolna Rebbe & Rachmastrivker Rebbe with the Tehilim from The original R Dovid Tolner Zya at his Hilula Tish Jerusalem last night Netsach ShbeNetsach. Unity Inspires Projects - United Souls 53 - One Flame Festival, True Freedom & Elevation is Making Space for the Mashiach Flow! https://eligoldsmith.substack.com/p/unity-inspires-projects-united-souls-b8e #unitedsouls #unityprojects #oneflamefestival #truefreedom #mashiachflow

The Leinster Senior Camogie Semi Final was almost abandoned yesterday after 30 players lined out wearing shorts, which are not permitted under the rules. After a conversation with the referee, they returned to the dressing room and changed into skorts, a hybrid between skirts and shorts. Journalist Sarah Slater tells us more.

In this episode, we continue exploring the topic of permitted speech on Shabbat, focusing on commercial matters, communal concerns, and specific cases like announcing lost items or nullifying excommunications. We discuss whether these actions align with Shabbat observance and when exceptions are made for community needs. Join us as we break down the halachic perspectives on these important issues.

What Happens After Death: Episode 13- Will Ibadah Be Permitted in the Grave by Radio Islam

What Happens After Death: Episode 12- Permitted ‘Luggage' for the Trip to Barzakh by Radio Islam

 Questions? Comments? We love feedback! Email us at info@baishavaad.org 

 Questions? Comments? We love feedback! Email us at info@baishavaad.org 

Interview with Frederick H. Earnest, President & CEO, Vista Gold CorpOur previous interview: https://www.cruxinvestor.com/posts/vista-gold-tsxvgz-smaller-scale-strategy-to-enhance-economics-5520Recording date: 4th of March, 2025Vista Gold Corp is transforming its approach to developing the Mount Todd gold project in Australia, one of the world's largest undeveloped gold resources with over 9 million ounces. The company is shifting from an ambitious large-scale operation to a more financially viable smaller project that better aligns with current market realities.The original development plan called for a 50,000 tons per day operation with capital expenditure requirements of approximately $1 billion. The revised strategy reduces the scale to 15,000 tons per day with a targeted capital requirement of under $400 million—a 60% reduction in upfront investment costs."For years we talked about Mount Todd as this big project... but a billion dollars US is still a big check to write," explained Fred Earnest, President and CEO of Vista Gold, in a recent interview at the PDAC convention.While the smaller operation would produce 150,000-200,000 ounces of gold annually compared to the original plan's 500,000 ounces, the economics remain compelling. The all-in sustaining costs are estimated at $1,300 per ounce for the smaller operation, compared to $960 per ounce for the larger version, still offering substantial margins at current gold prices.A key advantage of Mount Todd is its advanced permitting status, with all necessary environmental licenses and operating permits already secured. "Literally, I think we could write a letter and we could be in construction in two or three months' time," Earnest noted.The company is well-positioned financially to advance the project, ending 2024 with approximately $17 million in cash—providing a two-year runway without additional funding. This financial stability allows Vista Gold to complete the feasibility study for the smaller-scale approach, which is expected by mid-2025.For eventual project development, Vista Gold is exploring multiple funding avenues, including Australian debt sources like the Northern Australia Infrastructure Fund and equity financing through its North American listings.The strategic pivot comes at a time when the gold mining sector faces challenges in developing new large-scale projects in safe jurisdictions. By focusing on a more manageable development approach, Vista Gold aims to position Mount Todd as an attractive opportunity for mid-tier producers seeking growth through acquisition or partnership.Learn more: https://www.cruxinvestor.com/companies/vista-gold-corporationSign up for Crux Investor: https://cruxinvestor.com

Questions? Comments? We love feedback! Email us at info@baishavaad.org 

 Questions? Comments? We love feedback! Email us at info@baishavaad.org 

Parshas Vayeitzeh - Tricking a trickster: When lying is permitted (Halachah From The Parshah Series) 11/24/2020

Halachah From The Parshah Series: Parshas Vaeira and Bo - Magic Shows And Learning Magic Tricks: Is It Permitted? 12/29/2021

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The Primacy of Conscience, if well formed, permits faithful Catholics to resist popes making errors.Join this channel to get access to perks:https://www.youtube.com/channel/UCbgdypwXSo0GzWSVTaiMPJg/joinSources:https://www.returntotradition.orgContact Me:Email: return2catholictradition@gmail.comSupport My Work:Patreonhttps://www.patreon.com/AnthonyStineSubscribeStarhttps://www.subscribestar.net/return-to-traditionBuy Me A Coffeehttps://www.buymeacoffee.com/AnthonyStinePhysical Mail:Anthony StinePO Box 3048Shawnee, OK74802Follow me on the following social media:https://www.facebook.com/ReturnToCatholicTradition/https://twitter.com/pontificatormax+JMJ+

The Adventure Duo LOVES GORDON RAMSAY!!! Today we finally get to see what it's like to be him, like trying new foods, helping owners find their true potential, and putting a slop to a a rampant cannibal monster who thinks he can sell tiny burgers and pretend they're not sliders. Ya know the usual Kitchen Nightmare headaches. https://linktr.ee/id10tangos Try the Adventure for yourself @ https://chooseyourstory.com/story/kitchen-nightmares-but-gordon-ramsay-is-contractually-permitted-to-kill-the-owner-during-filming Sound effects: https://www.zapsplat.com Music: https://pixabay.com/music/upbeat-cooking-food-music-kitchen-chef-menu-vlog-background-intro-theme-261855/ https://pixabay.com/music/video-games-puzzle-game-bright-casual-video-game-music-249202/ https://pixabay.com/music/traditional-jazz-show-278110/ https://pixabay.com/music/dubstep-fight-epic-metal-dubstep-277580/

"Elon Musk has allegedly exposed an ideologically motivated cover-up of sexual abuse in Britain that was reportedly permitted by British authorities, including PM Starmer." 1650 Trial of Charles I

Episode #187: The Kallah That Almost Married Choson That She Wasn't Permitted To

Interview with Jay Chmelauskas, President & CEO of Camino Minerals Corp.Recording date: 8th January 2025Camino Minerals is advancing its copper portfolio through a strategic acquisition in Chile while pursuing exploration success in Peru. The company has announced the acquisition of the fully permitted Puquios copper project in Chile through a 50/50 partnership with Nittetsu Mining, where Nittetsu will contribute cash for their half while Camino will pay in shares.The Puquios project is positioned for near-term production, with a timeline of 2-3 years from purchase to first copper output. The project will require 6-12 months for debt financing followed by a 24-30 month construction period. Based on historical definitive feasibility study work, Puquios is expected to produce 9,000 tonnes of copper per annum over a 10-14 year mine life, utilizing SX-EW processing to mine an enriched chalcocite-oxide resource.The project's development is significantly de-risked through the partnership with Nittetsu Mining, who will take over as operator once a production decision is made. Nittetsu brings valuable operational synergies, as they are currently building their own $400M copper mine just 50 kilometers from Puquios.In parallel, Camino is advancing its Los Chapitos copper project in Peru, where Nittetsu has already invested $7 million to earn a 35% stake. The company plans to resume drilling in January, targeting 11 high-priority targets. The property shows significant exploration potential, with two major deep-seated structures identified across its 12-kilometer length. The project's prospects have been further validated by mining giant Rio Tinto's recent staking of ground along the same structural extensions.CEO Jay Chmelauskas, who is personally taking a 10% stake in the company's current financing round, sees significant opportunity in the copper market. The company is positioning itself to capitalize on projected copper supply deficits driven by increasing demand from electric vehicles and renewable energy infrastructure.Puquios offers expansion potential beyond its initial mine plan, with a substantial sulphide deposit beneath the oxide resource that could be exploited through new leaching technologies. The company is also exploring opportunities to incorporate mineralization from local Chilean miners to extend the mine life.The project benefits from its location in Chile's copper-rich Antofagasta region, with excellent access to power, water, and transport infrastructure. With DFS updates expected by January 2025, Camino is on track to potentially begin construction in 2026, targeting first production by late 2027 or early 2028.View Camino Minerals' company profile: https://www.cruxinvestor.com/companies/camino-mineralsSign up for Crux Investor: https://cruxinvestor.com

PREVIEW: With James Hasson, co-author with Jerry Dunleavy of KABUL, regarding how Marine snipers identified the suicide bomber but were not permitted to engage. More later. 1900