Podcasts about computational chemistry

In our first episode of 2025, our hosts, Chris Williams and Dave Thompson, have the pleasure of speaking to Fernando Garces, CEO and co-founder of BioGlyph. Leading us from the sunny climes of Portugal through the tropical paradise that is London, on route to the West Coast of the US and A, Fernando shares his evolving love of science through the heights of academia, into industry, and now as CEO of a software company he co-founded to improve the modeling of complex multispecifics. Important questions are unpacked throughout - is London really a tropical paradise? How long can we keep milking podcast episode titles that take advantage of the homophonic property of pharma and farm? Oh, and we have another surprising guest answer to the ‘Deschênes Dilemma'… It is not to quote G. K. Chesterton, a proper nailbiter!

In our final episode of 2024, host Chris Williams and guest co-host, Under the Surface Executive Producer and CCG Vice President, Alain Deschênes have a long overdue chat with computational drug discovery rock star Rebecca Swett. Rebecca shares her journey from her academic beginnings to her current role at X-Chem, via roles at Novartis, Vertex, and Relay. Rebecca's wide-ranging experience shines through as the conversation wends its way through cutting-edge computational chemistry covering machine learning, molecular dynamics, and DNA-encoded libraries. At the scale Rebecca works at, automation is key, so this topic comes up too. We're not going to lie; it's a lot. And, of course, there's more … Rebecca highlights the significance of allyship and representation for women in science, and the role of community (with a shout-out to the long-running BAGIM modeling forum). Also, in the inaugural asking of the ‘Deschênes Dilemma,' we find out what Rebecca would be doing if she wasn't doing all of the above …   

This episode, Breaking Math does a deep dive of “Towards equilibrium molecular conformation generation with GFlowNets” by Volokova et al in Digital Discovery Journal by the Royal Society of Chemistry. Hosts Autumn and Gabriel explore the intersection of molecular conformations and machine learning. They discuss traditional methods like molecular dynamics and cheminformatics, and introduce generative flow networks (GFlowNets) as a revolutionary approach to molecular confirmation generation. The conversation highlights empirical results demonstrating the effectiveness of GFlowNets, their scalability, and the importance of energy estimators in computational chemistry and drug discovery.Keywords: molecular conformations, machine learning, GFlowNets, computational chemistry, drug discovery, molecular dynamics, cheminformatics, energy estimators, empirical results, scalability, math, mathematics, physics, AIBecome a patron of Breaking Math for as little as a buck a monthYou can find the paper “Towards equilibrium molecular conformation generation with GFlowNets” by Volokova et al in Digital Discovery Journal by the Royal Society of Chemistry.Follow Breaking Math on Twitter, Instagram, LinkedIn, Website, YouTube, TikTokFollow Autumn on Twitter and InstagramFollow Gabe on Twitter.Become a guest hereemail: breakingmathpodcast@gmail.com

In this snippet from episode 214 of ‘Under the Microscope,' Dr. Pranoti Kshirsagar talks with Amber Lim about her shift from aspiring to be a high school chemistry teacher to becoming a leading figure in computational chemistry. Discover how her passion for science evolved, the challenges she faced, and the insights she gained along the way. Listen to the full episode - ⁠214. Crystals, Comics, Calculations, Chemistry ft. Amber Lim Tune in to explore more about Amber's inspiring career journey!

In recent years, the AI landscape has seen huge advancements, from the release of Dall-E 2 in April 2022 to the emergence of AI music and video models in early 2024.While creative tools often steal the spotlight, AlphaFold 2 marked a groundbreaking AI breakthrough in biology in 2021. Since its release, this pioneering tool for predicting protein structures has been utilized by over 1.7 million scientists worldwide, influencing fields ranging from genomics to computational chemistry.In this episode, DeepMind's VP of Research for Science, Pushmeet Kohli, and a16z General Partner Vijay Pande discuss the transformative potential of AI in scientific exploration. Can AI lead to fundamentally new discoveries in science? Let's find out. Resources: Find Pushmeet on Twitter: https://twitter.com/pushmeetFind Vijay on Twitter: https://twitter.com/vijaypandeLearn more about Google DeepMind: https://deepmind.googleRead DeepMind's AlphaFold whitepaper: https://deepmind.google/discover/blog/a-glimpse-of-the-next-generation-of-alphafoldRead DeepMind's AlphaGeometry: https://deepmind.google/discover/blog/alphageometry-an-olympiad-level-ai-system-for-geometryRead DeepMind's research on new materials: https://deepmind.google/discover/blog/millions-of-new-materials-discovered-with-deep-learning/Read DeepMind's paper on FunSearch, focused on new discoveries in mathematics: https://deepmind.google/discover/blog/funsearch-making-new-discoveries-in-mathematical-sciences-using-large-language-models Stay Updated: Find a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this episode of Molecule to Market, you'll go inside the outsourcing space of the global drug development sector with Arvid Söderhall, CEO at Empros Pharma. Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with Arvid, covering: The personal story of a pediatrician treating an obese child that led to the creation of Empros Pharma and its lead asset The 10-year journey from an idea to a successful Phase IIb trial... and what it felt like to reach the magic milestone Critical characteristics required for a small pharma leader, and why CEOs stand and fall with their data The ins and outs of a CDMO selection process for Phase 3 trials and the commercial launch for a global drug to complement GLP-1 products How the investor climate has changed in the last 1-2 years... and how it has it turned upside down in the hot obesity space Arvid joined Empros as a project manager in 2013, during the company's foundational phase, before the EMP16 project was named. He quickly ascended to CEO, steering Empros to prioritize its founders and inventors while leveraging a strong network of contacts and leading Empros to a phase 3-ready project that surpassed initial expectations. He holds a Ph.D. in Physical Chemistry with a specialization in Computational Chemistry. He then completed a postdoctoral fellowship in Berlin, marking his first engagement with the pharma industry and filing a first patent, introducing a foray into biotech entrepreneurship. Subsequently, Arvid worked at Stockholm-based biotech ‘Sidec,' focusing on cryo-electron microscopy of proteins. Despite the premature technology leading to Sidec's closure, the foundational concept later earned a Nobel Prize, underscoring the importance of timing in innovation. Please subscribe, tell your industry colleagues, and join us in celebrating and promoting the value and importance of the global life science outsourcing space. We'd also appreciate a positive rating! Molecule to Market is sponsored and funded by ramarketing, an international marketing, design, digital, and content agency helping companies differentiate, get noticed, and grow in life sciences.

Bringing Chemistry to Life is as much about the people behind the science as it is about the science itself. We've been remiss in sharing a bit more about the creator and host! In this unique episode we flip the script and move Paolo from the host chair to the guest chair to hear his story. From Paolo's childhood memories watching his father fix electronics and his dreams of being in the NBA, he chats about developing into a skilled bioorganic chemist, working in biocatalysis and his contributions to international study programs. He describes the “God-like” powers that organic chemistry gave him, manipulating matter and creating things that didn't exist before and how this led to becoming an R&D leader in a startup. Our protagonist's story takes a turn when he discovers and becomes enamored with the “dark side” of science finding success in sales, product management, and product marketing roles, where we find him today. The origin story of Bringing Chemistry to Life is uncovered, fulfilling his aspiration of being a podcast host while keeping him connected to great science and market trends. Join us to meet Paolo, your host, learn what he gets from hosting the podcast, and what he hopes listeners get from it!Related episodes: Season 1, Ep.1: Human milk — its a matter of chemistry (aka The Start of it All) Season 4, Ep.2: Paul Anastas — The father of green chemistry (aka A Dream Come True)  Bonus content!Access bonus content curated by this episode's guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more.View the video of this episode on www.thermofisher.com/chemistry-podcast. A free thank you gift for our listeners! Visit the episode website and request your free Bringing Chemistry to Life t shirt.Use Podcast Code:  liV4chem in February or laBcheM in March We read every email so please share your questions and feedback with us! Email helloBCTL@thermofisher.com About Your HostPaolo Braiuca grew up in the North-East of Italy and holds a PhD in Pharmaceutical Sciences from nearby esteemed University of Trieste, Italy. He developed expertise in biocatalysis during his years of post-doctoral research in Italy and the UK, where he co-founded a startup company. With this new venture, Paolo's career shifted from R&D to business development, taking on roles in commercial, product management, and marketing. He has worked in the specialty chemicals, biotechnology, and pharmaceutical markets in Germany and the UK, where he presently resides. He is currently the Director of Global Market Development in the Laboratory Chemicals Division at Thermo Fisher Scientific™ which put him in the host chair of the Bringing Chemistry to Life podcast. A busy father of four, in what little free time he has, you'll find him inventing electronic devices with the help of his loyal 3D-printer and soldering iron. And if you ask him, he'll call himself a “maker” at heart.

This podcast format is inspired by the Charles Dicken's novella “A Christmas Carol” whereby Phil Jeffrey (Bicycle Therapeutics), Beth Williamson (UCB) and Daniel Price (Nimbus) discuss DMPK Past, Present and Future with Scott.  Key elements discussed include the evolution of DMPK as a predictive discipline that links helps the chemistry of drug design with the biology of drug disposition and effect.The episode addresses the following questions:The founding names and principles of DMPK and the emergence of Discovery DMPKToday's use of technologies and in silico modelling and DMPK's role in the 3 pillars/5Rs and PK/PD The outlook for better prediction with advances in AI/MLSpeakers:Phil Jeffrey - Senior Vice President of Preclinical Development at Bicycle TherapeuticsPhil Jeffrey is now semi-retired after contributing to DMPK for over 35 years in the pharmaceutical industry.  Most recently, Phil was Senior Vice President of Preclinical Development at Bicycle Therapeutics and previously has held positions at Pfizer, GlaxoSmithKline, SmithKline Beecham and The Upjohn Company.  Phil is a longstanding contributor the Society for Medicines Research and is an Honorary Professor at the William Harvey Research Institute, Queen Mary University of London.  Phil has a wide breadth of experience across DMPK from, Drug Discovery and early lead optimisation through to clinical proof of mechanism and proof of concept across a wide variety therapeutic areas and drug modalities and made significant contributions to the advancement of understanding the CNS penetration of drugs into the brain. Beth Williamson - Head of ADME in the DMPK group at UCBBeth graduated with a PhD in Pharmacology from the University of Liverpool and is now Head of ADME in the DMPK group at UCB where she also represents DMPK on projects throughout discovery and development. Beth's work has focussed on in vitro and in vivo ADME assay optimisation and validation within drug discovery, particularly to address bespoke questions. Beth has worked in the fields of oncology, neurology and immunology. Her main research interests include drug-drug interactions, extrapolation of pre-clinical in vitro and in vivo data for the prediction of human pharmacokinetics and application of AI/ML approaches within DMPK.  Daniel Price - Vice President of Computational Chemistry & Structural Biology at Nimbus TherapeuticsDr. Daniel Price is Vice President of Computational Chemistry & Structural Biology at Nimbus Therapeutics, where he leads a team of internal and external scientists focused on delivering breakthrough medicines through structure-based design, leveraging both physics-based and knowledge-based predictive modeling.  Before joining Nimbus, he spent 16 years at GlaxoSmithKline, where he led a team of computational chemists and data scientists across diverse areas of structure- and ligand-based drug design, high-content screening analytics, predictive ADME, predictive synthesis, and chemogenomics.  He has led drug discovery programs, contributed to 4 clinical candidates, led the development of GSK's first generation R&D data lake, and authored/co-authored 26 publications.  Dr. Price received his undergraduate degree in chemical engineering from University of Colorado at Boulder followed by his Ph.D. in Molecular Biophysics & Biochemistry from Yale University with Prof. Bill Jorgensen.   He completed an NIH postdoctoral fellowship with Prof. Charlie Brooks, III at The Scripps Research Institute prior to joining GSK. Stay tuned for more podcasts in our Pharmaron DMPK Insights Series!

Visit https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the guest content sheet, which contains links to recent publications and additional content recommendations for our guest. You can also access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt. This started with a TV in the background showing Brazil playing Croatia in the World Cup quarter-finals, and ended with Brazil's surprising defeat, to the dismay of our guest, Brazil-born Gabe Gomes. In the middle, the most approachable conversation you'll ever hear about computational chemistry.Gabe tries to solve real world problems using computers and it's almost a paradox that such an extroverted, fun guy, in love with music and speaking so much about people, ends up investing his life in machine learning algorithms. Yet it takes courage, creativity, and daring to go in new directions and seek the next big problem at the interface of scientific disciplines.Chemistry is a complex multivariate problem and resolving this complexity is the key to the fundamental understanding we need to advance the discipline. Gabe is a wonderful chaperone in our journey to discover how automation and optimization can be used not to replace chemists, but to free them to apply their skills where in matters most. Gabe is the living demonstration that computers and humans can be part of the same discourse.

Martina Lessio, Scientia Lecturer in the School of Chemistry at UNSW Sydney, and her team are researching the best uses for minerals for purifying water, how we can use carbon dioxide and plastic waste for energy storage, and how we can preserve valuable marble artworks from water damage. How does she do so many things at once? Join this conversation with Martina to find out how high-performance computing makes all this possible.Find out more:Dr. Martina Lessio Website: https://www.unsw.edu.au/staff/martina-lessioTwitter: https://twitter.com/martina_lessioLearn more about the National Computational Infrastructure (NCI):Website: https://nci.org.au/Twitter: https://twitter.com/NCInewsLinkedIn: https://www.linkedin.com/company/national-computational-infrastructure/Thanks to James Beattie (ANU) for the astrophysics visualisation used in the artwork, and to Andy Maher for the show production (andymaher.com).

References J of Computational Chemistry 2011 Volume32, Issue10: Pages 2077-2083 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

For more details, visit #DrGPCR Podcast Episode #61 page https://www.drgpcr.com/episode-61-with-dr-marta-filizola/ ------------------------------------------- About Dr. Marta Filizola Dr. Marta Filizola is the Sharon & Frederick A. Klingenstein-Nathan G. Kase, MD Professor in the Departments of Pharmacological Sciences, Neuroscience, and Artificial Intelligence and Human Health, as well as the Dean of The Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, in New York, USA. The overall goal of her research program is to obtain rigorous mechanistic insights into the structure, dynamics, and function of important classes of membrane proteins and prominent drug targets, including G protein-coupled receptors (GPCRs), transporters, channels, and 3 integrins. To this end, her lab uses several computational structural biology tools and rational drug design approaches, ranging from molecular modeling, bioinformatics, cheminformatics, molecular dynamics simulations, free-energy perturbations, machine learning, etc. A native of Italy, she received her Bachelor's and Master's degrees in Chemistry from the University Federico II in Naples. She pursued a Ph.D. in Computational Chemistry at the Second University of Naples and a postdoctorate in Computational Biophysics at the Molecular Research Institute in California, USA. ------------------------------------------- Imagine a world in which the vast majority of us are healthy. The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together. To build our #GPCR Ecosystem, we created various enabling outlets. For more details, visit our website http://www.DrGPCR.com/Ecosystem/. ------------------------------------------- Are you a #GPCR professional? - Register to become a Virtual Cafe speaker http://www.drgpcr.com/virtual-cafe/ - Subscribe to our Monthly Newsletter http://www.drgpcr.com/newsletter/ - Listen and subscribe to #DrGPCR Podcasts http://www.drgpcr.com/podcast/ - Support #DrGPCR Ecosystem with your Donation. http://www.drgpcr.com/sponsors/ - Reserve your spots for the next #DrGPCR Virtual Cafe http://www.drgpcr.com/virtual-cafe/ - Watch recorded #DRGPCR Virtual Cafe presentations: https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw - Bring in a #GPCR Consultant http://www.drgpcr.com/consulting/ - Share your feedback with us: http://www.drgpcr.com/audience-survey/ - Become a #DrGPCR Ecosystem Member http://www.drgpcr.com/membership/

Prof. Anna Krylov is a Professor of Chemistry at the University of Southern California (USC), working in the field of theoretical and computational quantum chemistry. She has a M.Sc. in Chemistry from Moscow State University (1990) and a PhD from The Hebrew University of Jerusalem, Israel (1996). Krylov is active in the promotion of gender equality in STEM fields, especially in theoretical chemistry. She created the web directory 'Women in Theoretical and Computational Chemistry, Material Science, and Biochemistry'. She has delivered several talks on gender equality in STEM. In June 2021 she published a paper, "The Peril of Politicizing Science," has received over 75,000 views (as of February 2022) and is the all-time highest-ranked article in the Journal of Physical Chemistry Letters (impact factor of 6.5). Show notes: sigmanutrition.com/episode425/

Dr. Hoby Wedler has been blind since birth and, as you will hear in this episode, is definitely unstoppable. He is a scientist, an entrepreneur, a sensory expert, and is driven by his passion for innovative, creative, and insightful thinking. In 2016, Hoby earned his Ph.D. in organic chemistry from UC Davis. In the same year, he began opening doors to the world of wine aromas by developing Tasting in the Dark, a truly blindfolded wine experience, in collaboration with the Francis Ford Coppola Winery. Hoby has just launched his own line of spices and other tasty products. He is also a recognized public speaker. Among other positions, Hoby serves as the board chair for the Earle Baum Center of the Blind in Santa Rosa California. Now, come hear this inspiring and unstoppable person in action. Some directories do not show full show notes. For the complete transcription please visit https://michaelhingson.com/podcast About Our Guest: Dr. Hoby Wedler is an insightful, disarming, and passionate thinker who loves to bring people together to help them see new possibilities. With the heart of a teacher, Hoby helps turn your dreams into realities. Hoby has been completely blind since birth. He is a scientist, an entrepreneur, a sensory expert, and is driven by his passion for innovative, creative, and insightful thinking. Hoby is remarkably tuned into his surroundings and has frequently chosen to walk the unbeaten paths in life over known territories. In 2016, Hoby earned his Ph.D. in organic chemistry from UC Davis. His fearlessness is infectious, and he has actively paved the way for others to join him in his quest to follow passions regardless of the challenges that lie ahead. In 2011, Hoby founded a non-profit organization to lead annual chemistry camps for blind and visually impaired students throughout North America. In the same year, he began opening doors to the world of wine aromas by developing Tasting in the Dark, a truly blindfolded wine experience, in collaboration with the Francis Ford Coppola Winery. He has since expanded the program to a global market in a variety of industries and special projects. Over the years, Hoby has become a motivational speaker, a mentor, and an educator. He is also committed to making the world an inclusive, equitable, and accessible place for everyone. In his work, you will find a unique trilogy between sensory awareness, scientific knowledge, and a love for sharing his insights. Numerous people and organizations have recognized Hoby's work over the years. To name a few, President Barack Obama recognized Hoby by naming him a Champion of Change for enhancing employment and education opportunities for people with disabilities. Also, Forbes Media named Hoby as a leader in food and drink in their 30 under 30 annual publication. Hoby's dedicated to impacting everyone he works with by unlocking doors, overcoming challenges, increasing awareness, and expanding their horizons. About the Host: Michael Hingson is a New York Times best-selling author, international lecturer, and Chief Vision Officer for accessiBe. Michael, blind since birth, survived the 9/11 attacks with the help of his guide dog Roselle. This story is the subject of his best-selling book, Thunder Dog. Michael gives over 100 presentations around the world each year speaking to influential groups such as Exxon Mobile, AT&T, Federal Express, Scripps College, Rutgers University, Children's Hospital, and the American Red Cross just to name a few. He is Ambassador for the National Braille Literacy Campaign for the National Federation of the Blind and also serves as Ambassador for the American Humane Association's 2012 Hero Dog Awards. https://michaelhingson.com https://www.facebook.com/michael.hingson.author.speaker/ https://twitter.com/mhingson https://www.youtube.com/user/mhingson https://www.linkedin.com/in/michaelhingson/ accessiBe Links https://accessibe.com/ https://www.youtube.com/c/accessiBe https://www.linkedin.com/company/accessibe/mycompany/ https://www.facebook.com/accessibe/ Thanks for listening! Thanks so much for listening to our podcast! If you enjoyed this episode and think that others could benefit from listening, please share it using the social media buttons on this page. Do you have some feedback or questions about this episode? Leave a comment in the section below! Subscribe to the podcast If you would like to get automatic updates of new podcast episodes, you can subscribe to the podcast on Apple Podcasts or Stitcher. You can also subscribe in your favorite podcast app. Leave us an Apple Podcasts review Ratings and reviews from our listeners are extremely valuable to us and greatly appreciated. They help our podcast rank higher on Apple Podcasts, which exposes our show to more awesome listeners like you. If you have a minute, please leave an honest review on Apple Podcasts. Transcription Notes Michael Hingson  00:00  Access Cast and accessiBe Initiative presents Unstoppable Mindset. The podcast where inclusion, diversity and the unexpected meet. Hi, I'm Michael Hingson, Chief Vision Officer for accessiBe and the author of the number one New York Times bestselling book, Thunder dog, the story of a blind man, his guide dog and the triumph of trust. Thanks for joining me on my podcast as we explore our own blinding fears of inclusion unacceptance and our resistance to change. We will discover the idea that no matter the situation, or the people we encounter, our own fears, and prejudices often are our strongest barriers to moving forward. The unstoppable mindset podcast is sponsored by accessiBe, that's a c c e s s i  capital B e. Visit www.accessibe.com to learn how you can make your website accessible for persons with disabilities. And to help make the internet fully inclusive by the year 2025. Glad you dropped by we're happy to meet you and to have you here with us.   Michael Hingson  01:23 Welcome to another episode of unstoppable mindset. Today, we have really fascinating guests. He comes from the scientific community, as an essence, have I as you all know, because of my getting a master's degree in physics and being involved in various scientific endeavors, and our guest today Hobi Wendler comes from a different process. But by the same token, he also comes from the scientific world, specifically chemistry. You're going to hear about that, and lots of stuff today. So hope you welcome to unstoppable mindset. And thanks for being here.   Dr. Hoby Wedler  01:58 Mike, thank you so much. It's a real honor to be here. I think it's so cool what you're doing with the podcast and just very happy to be a guest.   Michael Hingson  02:07 Well, I'm looking forward to having a lot of fun. And I think we'll find some interesting things to talk about. So my   Dr. Hoby Wedler  02:13 it's all about, it's all about just jiving, and in coming up with, with topics that makes sense   Michael Hingson  02:20 and stuff. Yeah, exactly. So needless to say, I think we played it a minute ago, you are blind, you've been blind your whole life.   Dr. Hoby Wedler  02:29 I have never seen anything. There you go. Well, I've   Michael Hingson  02:32 had a little bit of light perception I did when I was growing up. And I didn't even notice that it went away. But at one point in my life, it suddenly dawned on me that I'm not even seeing light anymore. And when I went to an ophthalmologist, I find out that cataract had developed over my eyes, but I couldn't convince them to get rid of the cataract because it's not going to do you any good. And I said, Well, I might see light again.   Dr. Hoby Wedler  02:55 Mike, what is it? This is an interesting question. As someone who has literally never been able to see at all, what does it feel like to see like you describe that sensation?   Michael Hingson  03:06 I don't know how to really describe it. So the problem is, it's like, I asked people all the time, what is it like to see red? Or what is it like to do? Or what is it? Or since we both do it? What is it like to hear? We can simulate not hearing by completely covering our ears and cutting out all sounds? And there are ways to do that. I don't know whether that's exactly the same as profoundly deaf people experience not hearing, but how to describe hearing as such, or how to describe seeing, yeah, I don't know how to do that. I've only heard people do it with analogies. You know, red well, they talk about hot fire rages. Yeah. So let me see if I can try this. Have you ever been walking along and crashed your forehead into a wall or something?   Dr. Hoby Wedler  04:06 I was born blind, you know? Yes.   Michael Hingson  04:09 Well, you know, but you might be really good. But when what happens? What happens? What do you experience the the moment you do that?   Dr. Hoby Wedler  04:17 It's that feeling of sudden stopping and a little startling.   Michael Hingson  04:24 So for me, when that happens, you know, you've probably read books where someone gets hit on the head and so on. And suddenly they see stars and yeah, and, and I'm wondering if you see any other kind of foreign or you experience any other kind of foreign sensations? I   Dr. Hoby Wedler  04:40 don't know. You know, it's so funny because as someone who's never been able to see, I honestly don't know. It's such an interesting and good question though. You know, it's interesting actually thinking about senses in general in the sense of smell. Because the and that's an area where I do a lot of work and spend a lot of my time a lot of people lost either their sense of smell or taste or both during the pandemic that we're just coming out of, or maybe not. And, and talk about the fact, I've read countless articles now say, I just find it all fascinating. They talk about the fact that they didn't realize how much they used those two senses until they weren't there until they weren't there. And I find that so fascinating, because you and I, whether whether it's subconscious or not, we use our sense of smell the navigate all the time, or I think we do I do.   Michael Hingson  05:38 Well, actually, in the spirit of full disclosure, I discovered in 2013, that I had lost pretty much all of my sense of smell and a lot of sense of taste. And it happened, I think, because I took one of those cold medications that in fact, caused that to happen. And it's never shaken it there. Well, there was zinc in it. And, you know, there have been others where I know that people haven't had that problem, but there were some that did. So I don't know what the formulary was that created that and caused it to happen. But, um, so I don't smell as well, I can still taste some differences in in wines, and certainly differences in foods, but it's not as sharp as it was.   Dr. Hoby Wedler  06:28 I'm sorry to hear that. That's no fun to lose that sense. It isn't.   Michael Hingson  06:31 But you know, the other side of it is that I know what I had, and I know the experiences from that. And so it still is helpful when I experienced tasting and so on, to know what was there. And so I can sort of fill in some of the gaps, which probably is is similar to what happens to people who lose their eyesight. I imagine that's true. They can they can fill in the gaps or not. And that is one of the reasons I'm a firm believer in people who are partially blind when they discover they're losing their eyesight, and they go to centers to learn about techniques. I am a firm believer that people should learn to travel under sleep shades centers should really be teaching people that it's okay to be blind and don't use your eyesight as much as you can. Yeah, because the reality is that they may very well lose the rest of it. And if they start to recognize now that their their world is really one of being blind, then their eyesight will help them all the more for it and that will turn to trust a cane. Ken Jernigan, the past president of the National Federation of the Blind, created and wrote an article called a definition of blindness, which anyone can read if they go to the NFB website, www.nfb.org NFP being National Federation of the Blind. But what Dr. Jernigan says, Because you are blind, if you have lost enough eyesight that you have to use alternatives to eyesight to accomplish tasks. Absolutely. Which doesn't mean that you've lost all of your eyesight.   Dr. Hoby Wedler  08:13 Yeah, no, it doesn't. And I say, oh, go ahead. Go ahead. I was just gonna say in that sort of vein, I honestly think and this is often contrary to what a lot of sighted people think. I think you and I have it easier than the people who have partial sight?   Michael Hingson  08:30 Oh, I think so in a lot of ways, because we grew up with it. But also we we had parents who encouraged us and we had other parts of the community that encouraged us, and our makeup allowed us also to resist people telling us what we couldn't do.   Dr. Hoby Wedler  08:46 Right. Well, and I, to your point, I think so much of success, or there is a failure in the disabled disability world comes down to the support system that surround early on and particular particular families and that parental support. Man, that's a huge thing. If our parents were overly protective of us and held us back and locked us away when we were babies. Think about what we wouldn't have done and tried to do now.   Michael Hingson  09:16 I have, I have met people who actually lived in Chicago when I lived in Chicago. I was born in 1950. So you can do the math, anyone. But for the first five years of my life, I lived in Chicago. I was born two months premature. A lot of kids were it's a part of the whole baby boomer era, right? But I have met people since both even as a child but then later, whose parents sheltered them a lot more. And I saw and continue to remember what I experienced about what they could and couldn't do and how house self sufficient or independent, or even mentally thinking about being self sufficient or independent they were or they weren't. And the reality is that kids who are more sheltered, don't grow up learning a lot of the things that that they could learn just by being out in the world. And that's why I am a firm believer that parents need to what we would probably say today is take more risks. It is that's absolutely right. It isn't really a lot of risk taking it is really, your child being exposed,   Dr. Hoby Wedler  10:33 it might feel like risk taking, but it really isn't, you know, it's I mean, it is, in some ways, if there be take that, you know, if you if you do things that are, some people might, I can see why people would call it that. But you know, there's another another element of parenting. Children who are blind that I think is so crucial and often gets unnoticed is the idea of talking and seeing what you're doing. That is where my parents really one of the areas, they really excelled. They in the kitchen, for instance, when they were making breakfast, they would describe I remember my mom describing exactly what she was doing. And I didn't think anything of it at the time, I was pretty young toddler. But now when I think back on it, I realized the whole point of that was that things didn't just happen mysteriously, you know, if you imagine raising a sighted kid and you get them a bowl of cereal, you know, they're going to see you get that walk over to the cupboard, get the bull's eye, okay, now I know where the holes are stored, or my cereal comes from, they're gonna see the box of cereal come out of a different cabinet, they're gonna see the cereal get poured into the bowl, they're gonna see the parent, go to the fridge and get the milk, they're gonna see the spoon get taken out of the drawer and set down on a napkin next to the bowl, and then they're gonna see this bowl be set before them. And it's not a mystery. But if you don't say anything, and you do all that with a blind kid, they're not gonna know the milk goes in the fridge. They're not, they're not gonna be able to figure that stuff out. So it's, you've got to talk about it.   Michael Hingson  12:03 And the children whose parents did that the chil the children whose parents recognized that no matter what the disability, it didn't mean that their child didn't have gifts and that they needed to do everything they could to and Hance or allow children to learn to use those gifts. Isn't that those are the lucky kids.   Dr. Hoby Wedler  12:28 Yeah. Yeah. And there are relatively few of us.   Michael Hingson  12:32 And there are relatively few of us. Some people are good. Some people have learned it later in life and have done well. But from from a standpoint of kids, there are there there are apparently, few of us, you're gonna ask,   Dr. Hoby Wedler  12:47 Oh, it's just gonna ask us for sort of mentioned that a comment or a question, rather, that I get a lot of the time is would you ever want your eyesight? And my answer to that is a resounding no. Because I don't want to have to learn how to really live in this world. I know braille, I read Braille, very proficiently, I don't need to learn print, I don't need to know what it looks like to drive down the road, I can roll my window down and smell the air, I can listen to the air blow by. So it's no I don't, I don't need to change the world I live in because I love the world I live in. And I don't want to throw the same question back at you. And ask you, you know, what is your response to that question?   Michael Hingson  13:27 I respond a little bit differently than you. But it amounts to the same thing. And that is? Well, yeah, I suppose I might be interested in doing it only because it would be another adventure. But the reality is, I'm very comfortable in my skin. And I and I also know, in a sense, what visually I don't see. So driving down the road, the experience of driving and doing the things that that sighted people do, being able to drive and avoid that car that's coming at you and then stick out your your finger at them or so on. So some of that we don't get to do but also. I know that the time is coming, that we're all going to change. So I I have actually driven a Tesla down I 15 going from Delhi up here down toward Riverside and so on.   Dr. Hoby Wedler  14:24 I do not I tell me a little more about the story. How did this happen?   Michael Hingson  14:29 I was going down to do a speech and the person who was taking me down, owned a Tesla. And we talked a lot about the technology and he said you want to drive it and I said sure. And so I reached over and basically it was in a a well, copilot I won't say a self driving mode but copilot so it was watching what was going on on the road. And basically it required that someone keep their hand on the wheel. So it wasn't that I was doing a lot of work. But we had programmed into the GPS where we were going, and the Tesla and the automation, steer the vehicle, we avoided cars and so on. So I got a great feel for it. And I recognize that the car was in control. But I've also been to Daytona, yeah, in 2011, for the Rolex 24 race and the Blind Driver Challenge, the challenge where Mark Riccobono, the current president of the National Federation of the Blind, drove a car independently around the Daytona speedway. And that was using technology that gave him the information so that he could drive the car, not with automation, like in a Tesla, but literally drove the car, avoiding obstacles, and so on. And he had to do all of the work. And I did, I did drive the simulator, so I got a feel for it. But I also know that we're all eventually going to be using autonomous vehicles, a lot of things are going to change. And the other part to answering your question is, oh, my God, I don't want to be able to see and do what those people do. There are too many crazy drivers on the road. I don't want to be responsible for that.   Dr. Hoby Wedler  16:11 You got it? Yeah, absolutely. Tiger.   Michael Hingson  16:15 But you But you, you had very good parents, you were very fortunate in terms of being encouraged to do what you you do and what you did. So where did that take you? You went out of high school, you went into college? What did you do in college? And what was your major and all? Yeah, you   Dr. Hoby Wedler  16:32 know, my parents, just to just to circle back a little bit, or, or, like, they dispense still on my biggest supporters. And, you know, they, they did two things really, really, really did many things really well. But I'll focus on two right now. My brothers two years older and sighted. And the first major thing is they treated us with the same high expectations, I was not given lower expectations to follow, because I happen to be blind. And keeping us both to the same high high standard was really crucial to me growing up and, and being an active participant in this world we call home. They also taught us that the most important thing we can do is to take responsibility for ourselves, our lives and our actions. And hey, if we take responsibility and challenge ourselves in situations, and we succeed, we deserve the credit for that success. And frankly, if you fail, you deserve to take the blame. And that that pushed me and my brother so far. I see a lot of a lot of blind kids with sighted peers. There's a little bit of jealousy. And there's a lot of Oh, yeah, you know, we have high expectations of one and not the other. And I just, I just don't think that's necessary. And I think it actually really creates bad feeling so, so grateful and very happy now that my parents just really pushed me and in a nice way, and expected, by the way, that we would have the same ultra high expectations of them. So that was a really powerful thing. Um, after high school, I went on, I was in high school when I fell in love with chemistry. When it came time, I took physical science and loved chemistry there. And then when it came to my junior year, I said, Well, shoot, I'll take the test to get an honors chemistry. And I'm not sure the instructor was really expecting me to take the test and get the top score on it. But I ended up taking the test. And then she's in a pickle of God, he took the test now what do we do get to get these, you know, we got to get him into the class. So sure enough, I came into the class. And it was a Yeah, it was a great experience, we found someone to work with me who had taken the class before, as my eyes in the laboratory. But the instructor would would do something kind of interesting. She would tell the class, you all should think about studying chemistry. It's amazing. We live it, we breathe it, we eat it, we drink it, it really describes the world around us. And I know the physicists out there saying now physics is a little more fundamental. So you can comment there, if you will. But I think chemistry is pretty darn fundamental. And she would tell me when I was in her classroom, getting assistance, solving problems and that sort of thing. I'd say, hey, let's, uh, you know, I want to study chemistry, I actually want to do what you're asking us to do. And she would say, Oh, holy, it's really impractical. It's such a visual science. I don't know how that's gonna work. And I still vividly remember the day the exact day that I went into a classroom was the second week of the second semester. It's early in the morning before students arrived. And I said, you know, you've been telling me that chemistry is a visual science and that it probably wouldn't make sense for me to study. But I gotta tell you, nobody can see at us. So therefore chemistry is truly a cerebral science. And she had a light bulb go off and said, Hmm, that's interesting. You're right. And from that point on, became an absolute supporter and ally, and still is a dear friend and supporter and everything I do. So that was an incredible opportunity to realize that, hey, chemistry really isn't a cerebral isn't visual science, it's in our head, we use our eyesight for some of what we pick up in the laboratory. But if you think about the electromagnetic electromagnetic spectrum running from, you know, very small distances of Pico meter length waves all the way up to several meters, there's only one little tiny itty bitty part that we can see, which is between 704 100 I should say it in a different order, 407 100 nanometer wavelength light. And that means there's a whole lot of other light that can be detected, that has nothing to do with our eyesight. And we used a lot of that light in terms of radio waves and microwaves and that sort of thing to understand what's going on in our in our chemical samples, and then review the data. So I ended up long story short, I'm sure you wanted a shorter answer than this. But I ended up studying chemistry in college and not really knowing that I was a nerd at that point and wanted to teach, I always had the heart of a teacher, that was always my goal is to, is to teach.   Dr. Hoby Wedler  21:18 I got a degree in United States history as well, because I knew that I was going to be in graduate school in order to teach and I didn't know how accessible chemistry was going to be. And I didn't necessarily want an assistant, you know, looking over my shoulder 16 hours a day in the laboratory. So I thought, well, let me let me study history, so that I have a backup plan. And I was actually and I minored in math just because I'm a nerd and can't help myself and found abstract algebra really useful for chemistry. And it's like, I took those three courses. And I don't know, some career counselor, some advisor in the math department said, you know, you're only two courses away from a math minor. Oh, okay. Well, I took a logic class and a history of math class, which I loved as well. And ended up with a minor in math. But beside the point, I ended up, I was ready to apply to history graduate schools throughout the state, actually, of California. When I met my graduate advisor, who studies Computational Chemistry, I worked in his lab for a while as an undergraduate. And as great mentors often do, he sort of saw a future for me in chemistry in computational chemistry, before I kind of saw it for myself, and just recommended that I study chemistry and in his group, and apply and hopefully get into graduate school, so I did, ended up doing both my undergraduate and graduate work at UC Davis, University of California Davis, which was interesting. And a reason one reason for that there's a few reasons but one main one, Mike, is that I didn't want to have to convince another group of staff in the chemistry department and faculty that I could do what I could do, it was just easier to work with people who are believed in me and trusted me, quite frankly, I'm ended up earning my PhD in 2016, and have gone on from there and done nothing in chemistry.   Michael Hingson  23:07 Well, as a physicist, I'm glad that we were able to help you by inventing light for you. So you know. But yeah, thank you, I really think I think both physics and chemistry are part of the universe, and it isn't really fair to ever say one is so much better than the other. I believe that's true, we would have a hard time living without chemists or physicists. And and I think both of us could also say, and we would have a hard time living without engineers, who everybody seems to pick off. So it's okay.   Dr. Hoby Wedler  23:40 We think we can handle the nitty gritty stuff, but we need someone to build things for us. Okay.   Michael Hingson  23:44 Yeah. And and we need someone to figure out what it is that we need to do to handle the nitty gritty. So the mathematicians count as well.   Dr. Hoby Wedler  23:52 That's it. No, absolutely. Well,   Michael Hingson  23:55 so you just said a very interesting thing. You graduated in 2016, with a PhD in chemistry, and then haven't done anything with it since? Why?   Dr. Hoby Wedler  24:08 Well, and I won't say I've done nothing with it. Once again. That's one society. Well, sure, once once you go that far, you're always a scientist. And I will always consider myself a chemist. I wanted to teach. I told you that. And I had the honor of teaching some undergraduate classes. And so my desire to teach was to get people early on, excited about something maybe they didn't know they were excited about. So I wanted to be that instructor who came into the freshmen chemistry class with, you know, four or 500 students at 8am. On a Monday morning after a long weekend partying and get some of those students. Now, 90 plus percent of them are there because chemistry is a prerequisite and they just can't wait to get it over with. Yeah, I want to get some of those students excited about studying chemistry beyond this, this general chemistry course. That was my passion. I wanted to be a chemistry lecture to the very early chemistry students, because that's when you can shake people and help change how they think about what's possible for them. And I taught several of those courses at Davis and I realized something that was hard to realize, which is that students did not speak chemistry, they want some explanation of what they see on the screen. But what they really want to see are pretty pictures and animations and videos showing exactly what's what's happening with a lot of this years. And that there's and then we put this over here, and we can see this red thing down over there and then be ready for the test on Friday. Now, I can't explain chemistry to you very well. But I need to use my words, mostly. Now, I do understand that many concepts are very much supported by images, and and graphs and charts and diagrams, and whatever the case may be. So I absolutely would spend time with assistants putting together PowerPoints with some of those images. And what I realized is I was spending a lot of time and money working on basically making beautiful presentations with beautiful video clips, and animations and things that would slide in and slide out and fly around just to keep the students entertained. And I'd have to spend hours memorizing these presentations so that I could talk about them cohesively as I, as I showed them, basically. And that was all time spent working with several different assistants. The other thing that I found disappointing was that students didn't read the textbook, if I would say, Okay, we're focusing on Chapter two sections three and four. Tomorrow, I would say maybe 2% of my students actually read the book, and came ready to talk about it. And for for those students out there, I will just tell you, if your instructor teaches from a book, read the book ahead of time. So that lecture feels like a review. Right? That's, that's really crucial, in my opinion. So one thing led to another and while I was in graduate school, concurrent with my graduate tenure, I had the opportunity of working with Francis Ford Coppola, I know you have as well. He asked me through a friend, I met him. And he asked me to host a truly blindfolded Wine Experience. And he said, You decide how this is done. The reason I'm asking you to do this, is I don't want it to be gaudy. And   Dr. Hoby Wedler  27:38 you know, so gamified, I want it to be real and authentic. And I commend him for wanting to have a blind person design and run this program, because I can use the blindfold. And I will never tell you, Hey, this is what it's like to be me, that would be silly. But what we can do is we can use the blindfold not at all as a toy, or as something gimmicky. That's the other thing Francis said, he said, above all OB, this can't be gimmicky, and I couldn't have agreed more. So, you know, we built out the experience. Where the blindfold is literally something that temporarily removes a sense that we use for to take in a lot of our information if we're sighted. So when we remove it logically, our other senses were differently. And we can focus on different variables, maybe we can focus more on how wine smells, maybe we can focus more when we're not distracted by our eyesight on how wine tastes. And maybe we can just focus on what's being sat around us a little more the voices that we hear that way, the chair we're sitting on feels, all sorts of things. And by the way, I really do believe and this is sort of an aside, that if you're going to do blindfolded stuff, you have to do it tastefully, and you have to do it well. And there are some programs out there that do it well, and there are a lot of programs out there that don't do it well. So I am one who really takes pride in giving sighted people that temporary experience and not distracted by eyesight in a way that does not be little, or suggests that this is what it's like to be me or anything of the sort. And I'm very, very careful about that. By the way.   Michael Hingson  29:18 That's one of the concerns I have about things that are called dining in the dark is that most people say you'll get to see what it's like to be blind. No, you won't. You don't have any of the training. You don't have any of the background. But I like what you say which is that if you treat eyesight as a distraction, or if you treat being blindfolded, as a way to avoid the distraction that goes along with eyesight, then you can use your other senses, which in fact for something like tasting are just as important, if not more, so unless There's something that's an absolute requirement for the presentation of the food. Absolutely. And, and I understand that, and I appreciate that we watched Food Network a lot, we see things about presentation and was my immediate reaction as well. So the taste of the food, but I also do appreciate that there is a place for presentation, but for tasting and so on, you need to get rid of distractions. It's like anything else, you need to get rid of distractions to focus on what it is that you want to focus on. And the last time the last time I heard, we didn't have eyes in our mouths so that we could see the wine as we're tasting it exactly in our mouths. So yeah, but But I hear what you're saying. So you did that with France.   Dr. Hoby Wedler  30:43 Someone asked me a funny question. When I was a freshman in college and the dining hall. They said, How can you eat when you don't know where your mouth is? And my response to them was like, That's news to me, I guess you with a rearview mirror on your head all the time? Not? Okay. You know? Yeah. It's just interesting. People's people's perception, people's perceptions. Yeah. So you work with friends you work through that, for a while actually took took it on the road pretty soon after we started as a hospitality experience for his wineries in Sonoma County, right. And as soon as the Sales Team National Sales Team heard about it, they wanted it for them. So we brought it on the road. And what's great about being a computational chemist is that my laptop was my laboratory. And my advisor was very willing to say, go travel and figure out what you want to do. So I worked with them. And I got really involved in this in the world of food and beverage, and that community in the sensory aspects of food and beverage and met a lot of really neat people who I thought were really interesting and really cool. And this is concurrent with teaching, feeling a little less accessible than it honestly could. So one thing kind of led to another and I found myself really loving the world of sensory design and designing high end experiences and products to an extent based on our non visual sensory input. And logically that works into food and beverage quite well. So I do a lot of personal consulting in the in the food and beverage world on product development, on tweaking products to make them even better than they already are. These sorts of things, we still do a lot of speaking a lot of these tasting experiences, when and where desired. There's nothing regularly scheduled, but I do them a lot as a consultant. And then I love thinking about creative as well. So it's not only science and taste, it's it's science and art, and how can we straddle that very fine intersection between science and art. And the way that I've come up with is through being creative. So I'm a creative thinker, and I thought that creative was a good thing to focus on. So I actually co founded a creative and marketing studio called cents point in 2017. And my business partner, Justin is here in California with me, our third partner, is our creative director as well, man named Jody Tucker, who's based down in Adelaide, Australia. And because of my love for food and beverage, and in gaining popularity in the industry, I just this last year started my own brand of gourmet seasonings, it's expanding a lot right now, by the way, in terms of the products that we have out there, we currently have two products on the market, hoagies essentials as the name of the brand, and we have a rosemary, salt, and a blend of sort of an all purpose dry rub that we're calling happy paprika, but that line is expanding very quickly into about half a dozen more products, probably before the end of the year. So we're really excited about that.   Michael Hingson  33:38 Well, we're gonna need to get some of those to, to put on meat when I barbecue and I do the barbecuing and the grilling in the house. So absolutely. We need to to work that. But so I'm going to ask right now, and I'll probably ask at the end, if people want to learn more about that. How do they do it?   Dr. Hoby Wedler  33:56 Where do they go to hobi.com? And that's H ovy.com. And that's got all my stuff? My my personal website, the homies essentials brand site, everything's there.   Michael Hingson  34:07 Yeah. Are any of the hobbies essential products being sold in any kind of mainstream markets yet? Or is it too new   Dr. Hoby Wedler  34:14 not a Gaussian distribution in Novato at p hardware? And you know, which it very well, it's a great place, isn't it? Yeah. And then Rex hardware up here in Petaluma, which is another H store and a couple of markets out in Sebastopol. So we're small but we're growing that retail presence.   Michael Hingson  34:34 So when do we get to see you on Shark Tank? Oh, you know Shark Tank?   Dr. Hoby Wedler  34:41 That'd be fun. Yeah, I'm an entrepreneur. I do a lot of it.   Michael Hingson  34:45 There you go. So when do we get to see you on Shark Tank? That's the question.   Dr. Hoby Wedler  34:48 Ah man, well, maybe sooner rather than later my funding dries up.   Michael Hingson  34:53 Or don't wait for it to dry but enhance it. There it is. There it is one of the things that in impressed as me and you know, needless to say, we've known each other a while and I've had a chance to, to watch you and so on and see what you do. You, you really do talk the talk. And by that I mean and walk the walk. But you, you act as a role model in a lot of ways. So yes, you've formed hobbies, essentially, yes, you helped create sense point design. But you've also taken it further, in that when you see opportunities to address issues regarding disabilities, I've seen that you've done a lot of that. And I know that one of the things that you have taken a great interest in is the whole idea of inclusion and access on the internet.   Dr. Hoby Wedler  35:43 Yeah, I do care a lot about that, and many other things as well. We started a nonprofit, which is now on hiatus called accessible science that basically basically brought blind kids together for annual chemistry camps, that enchanted Hills camp for the blind, and taught them how to do hands on organic chemistry. That was what we call it, but really, it was to teach them they could do whatever the heck they wanted them or how visual the career seems. And we've had students come from that and become, you know, get their get their PhDs and masters and all sorts of things and fields, they didn't really think were were possible for them to study. So it's kind of fun to just open minds a little bit to what's possible. And, and because the word mindset is in the, in the title of your part of your show here. You know, I think it's all about forming the right mindset. And with the right mindset, we can do anything we want. And the same thing, I think it's about, you know, making the internet more accessible, is all about mindset, and all about really thinking about the user while designing the webpage.   Michael Hingson  36:52 You have, you have clearly done a lot in the the the internet world and so on. And you've used your experiences with sense point design, as I said, and hope is essential as to to role model, what kinds of ways have you helped to influence what's occurring with access in the internet and so on?   Dr. Hoby Wedler  37:13 You know, number one, I just I think it's when we design websites for our clients, we think about that. And we want a solution because not all of us are accessible web accessibility experts. So our what I loved is kind of obsessively is a part of your life. When I found out about accessory it made perfect sense to me if there's a if there's an automated tool that we can use to help make websites fully accessible, that's exactly what I want. Because my team aren't necessarily experts in the in the accessibility. I mean, we know about accessibility and the WCAG you know that but some of these some of these people are really our experts and frankly, a lot of our clients can't afford what it takes to maintain a website is fully accessible it's 1000s of dollars a month. So they get really excited when I present them with a solution that's only $49 a month that makes their site very accessible across many different platforms. So that's that's the main way that I have found to fully it will take to make fully accessible the websites we consult on or design   Michael Hingson  38:27 how did you find accessible How did you discover it?   Dr. Hoby Wedler  38:30 That's a really funny story. I actually found excessively initially because my brother was chatting with your CEO about possibly investing in the company I'm not sure where that conversation went but he mentioned excessive yes or no that's interesting. And then a few years later a couple years later I saw the solution when looking for just good automated tools to make websites more accessible and contacted someone in your in your sales department a woman by the name of Jenna Gemma Fantoni don't know if you know her. But she then set us up as a as an affiliate partner accessory. So since point is an affiliate partner of accessory, and it's really easy to to use and make your site accessible.   Michael Hingson  39:15 What do you think about the people who have concerns about using an artificial intelligence system and an automated solution to help address access and inclusion, as opposed to the manual coding traditional way of dealing with it?   Dr. Hoby Wedler  39:32 I think there's a solution for every client and it's not going to be the same for anyone. I think if you can afford the the manual coding, which again is going to be several $1,000 a month, use it if that's what you want to do use it. I don't see any problem with automated tools. You know if we were talking about cars becoming more automated, I'll tell you that Elon Musk back in September We were a group of four civilians up to space, they orbit at higher than the International Space Station at 519 kilometers. These people didn't know how to fly spacecraft, but the automated spacecraft, flew them around the earth and low Earth orbit for 72 hours, launched them and brought them right back to Earth. And, boy, if that's not if that's not a suggestion that that automation and some AI can really help, I don't know what is. So when it comes to websites, I see absolutely no reason that it's a that it's a problem. Sure, there are things that it might miss. Yeah, that's, that could be true. But what's great about that you and I have an extensive talks about this. But when we find a problem, and we fix it in the back end of accessibility, we're fixing it for all the people who have accessible, not just that one website. So it really, it really is a practical solution. And I don't understand this one or the other approach, you know, it's let's be more inclusive and think about what's best for the client. You know, I've got clients who are more small wineries or use very small organizations that can afford to make their make their stuff fully accessible by hard coding. They are really excited by an option that makes their site accessible and usable by all parties. The other thing that accessory does the overlays like accessibility really well. And I think accessory does particularly well is thinking about other disabilities. It's not just those of us who are visually impaired. Think about blinking pulsating cursors for people with epilepsy, and how that might stimulate seizure. There's so many things that we can that we should be considering when we think about accessibility. And I really like a solution that includes all all parties and all folks in in that, that solution. So I really, I really do believe in accessibility, Oh, no.   Michael Hingson  41:59 Well, I have maintained for quite a while that when we talk about disabilities, and so on. In reality, the concept of diversity has gone away. People never talk about disabilities or very, very, very, very rarely talk about disabilities. When it comes to diversity. I mean, we were hearing regularly, especially every year around Oscar time about how there has to be more diversity. There have to be more women, there has to be different racial content, we have to have more directories of   Dr. Hoby Wedler  42:36 diversity, the photo has to look more diverse   Michael Hingson  42:39 in the photo, but they never talk about disabilities being a part of it. Why is it that we don't have a blind movie director? And why is it that we can't there's there's no reason. Now I don't know how to do it. And I am not interested in being a director. Although I'm sure I could learn to talk like one you know, and all that but, but I'm not really interested in being a movie director. But I suspect that there are some blind people who have the knowledge and the talent, certainly people in wheelchairs and so on. And Marlee Matlin is a person who is deaf has done a great deal in, in the entertainment world. But the reality is we don't get included. How do we change that conversation? At a basic level in society to get more inclusion, about people with disabilities, the conversations that we have?   Dr. Hoby Wedler  43:37 Yeah, it's an interesting question. You know, I think I see that from from multiple different angles, the first thing I'd say is that I personally believe that a blind person's perspective is an extremely diverse one, and a life that was lived very differently than others, and should be listened to. I also think that diversity means literally bringing people with different perspectives. It's not how they look or what their you know what their gender is, or anything like this. It's sure those things matter tremendously. But it's about the perspective that they bring that their upbringing and their background brings to the table. And I think if you have a more diverse team, you're going to have more perspectives at the table to come up with a broader solution to a problem. And frankly, in a business setting, a more diverse team is going to increase your bottom line fairly dramatically. Why specifically, are people with disabilities not included? I think we're trying to change that. I think we're trying to remind people, Hey, we, you know, those of us with disabilities have have perspectives that are very unique and very worth considering. And, you know, I think we need to just show society, what it is that we can do. You know, it's that's one of the reasons that I was happy to get the graduate degree that I got. And I imagine it's the same for you, even if you don't end up using it, you know, for academics, you know, people know that We know how to work hard. And but I think that a lot of the reason we don't get included is because not because people don't are angry with us and don't want to include us. It's simply because they don't know how to include us. They don't know what we can do. I think it's our job to educate people and say, Hey, no, we we can be right. They're at the table with you, you know, and help solve problems and all that sort of thing.   Michael Hingson  45:24 I think there's a fear element, but it comes down to not knowing right? People are also afraid of things they don't understand. They don't understand primarily disabilities. And they're also afraid, well, that could happen to me, which is probably the the best thought that they can have. Because the reality is, it could happen to you. So why aren't you including people up front who have disabilities, or who have those characteristics that you do not have? It's disabilities as a, as a classification is one of those characteristics that most people, including most people who happen to have disabilities today are not born with? It's true, but it is a characteristic that anyone can acquire.   Dr. Hoby Wedler  46:06 It's no one minority group that we all can and probably will join, if we live are lucky enough to live long enough,   Michael Hingson  46:12 in one way or another? Absolutely. And there's no reason for a lack of inclusion, one of the things I really love about accessibility is that it is really helping in its own way to change that the very fact that it's a scalable solution. Yeah, it's a solution that can work in so many ways. And accessibility is also now creating a suite of products that go beyond the overlay. But the other thing that I think that happened this year, that really excites me, is that excessive, be created a series of television commercials. Yeah. And everyone in the commercial had disabilities. It was all done with actors. Incredible.   Dr. Hoby Wedler  47:00 Yep. Showing and showing that this actually matters. And we are not only going to help people with disabilities, we're going to put them we're going to put them in our advertisements, putting them to work. Yeah, absolutely.   Michael Hingson  47:14 And the reality is, I don't I don't know all the the video vignettes that were shown, but I know a number of them. And the reality is that it really shows that we can be anywhere just like anyone else, which is, of course, one of the things that I hope people learn from, from my story, you know, we wrote thunder, dog, and so on, and it's all about fine people can be anywhere just like you including near the top of the World Trade Center in escaping. And it and it isn't luck to escape anymore than for anyone else it is in strategy. It is absolutely strategy and preparation. Yeah, it   Dr. Hoby Wedler  47:55 is. And being ready for that day. When it comes frankly, and, and having the training that you need. You know, I by the way, I'll just say something about commercials and people with disabilities, I've seen something that I don't particularly enjoy, which are people with disabilities being used for advertising purposes. And then to see the company not hiring people with disabilities, that's a little frustrating. So if we're going to show people with disabilities, let's make a commitment to bring them in on our team as well.   Michael Hingson  48:25 I think that's important. And I also think that companies that say that they're accessible, and they have a lot of visible stuff relating to so called Accessibility, don't really need to prove it. I've seen any number of products that come out, or get updated over the years, and accessibility gets broken. That should never happen. I agree. And it's it's truly unfortunate that those those kinds of things occur. Yeah, of course, it's easy to sit here and say excessive he can help with, with APA well with internet stuff right now to address that. And we'll see what happens with apps down the line. But sure, but but the fact of the matter is inclusion is something that we all should take very seriously. And we should adopt a more inclusive mindset. There's there's nothing wrong with doing that.   Dr. Hoby Wedler  49:17 No. It's important.   Michael Hingson  49:21 Well, it is and we have to do our part. And I think you've said it very well. We do have to be the educators and we we must work in an environment where we don't get offended or upset when people ask us questions, especially when they're really legitimately and obviously trying to learn. The last thing we want to do is to not be good teachers and discourage people. No, that's   Dr. Hoby Wedler  49:48 absolutely true. I would I would agree with that head over heels.   Michael Hingson  49:54 So where do you go from here? What what's next in your adventurous life?   Dr. Hoby Wedler  49:59 I think Working on this season's brand, getting it out there really, really trying to try to put together I'm actually working on a show right now just about experience in the food and beverage industry that we're going to try to popularize here. And that's going to be in the next probably latter half of say latter half, maybe mid mid part of, of 2022. And, yeah, just growing from there and see where see where the journey of food and beverage takes me. How's that?   Michael Hingson  50:30 Can you tell us a little about the show? Or is it too premature?   Dr. Hoby Wedler  50:32 It's pretty premature. I'll hold off on that. But I'll tell you why. After we do our pilot, maybe maybe you'll be kind enough to have me on again. And I'll tell you,   Michael Hingson  50:41 I would love to and you know, of course, if you need another blind person to to volunteer in any way, let me know.   Dr. Hoby Wedler  50:48 Thank you very much. I will do that. Even if tasting   Michael Hingson  50:51 isn't my forte at the moment. Well, I can taste salt. But you also do some other work. You're involved with some other nonprofits. I know you're the Chair of the Board of Directors of the Euro bound Center for   Dr. Hoby Wedler  51:05 the Blind. You and I both care deeply about the Euro bond center and are on the board. This great, it's a blindness Training Center in Santa Rosa, California, serving four counties, Sonoma, Lake, Napa, Mendocino, and I live in Petaluma, which is in Sonoma County. And it's pretty great to have an awesome training center in our backyard.   Michael Hingson  51:27 It's it's interesting, because during the pandemic, URL by Baum did some very interesting things to help keep classes going. And I know you did. And I participated remotely in some of the orientation and mobility classes in some of the other classes. Partly for encouragement, but also partly to help teach alternative techniques and use our skills to help people understand even if it's remotely how they can use good cane skills and other skills to be able to function. I was really impressed with Earl balms innovative approach to that because I saw other agencies that didn't do nearly as much of that. They had this well suspend classes until the the pandemic was over or until it lessened. Right, I'm not sure as you I'm not sure if it's over or not, or close to being over. But Earl balm was very creative in some of the things that it did.   Dr. Hoby Wedler  52:28 Well, they pivoted in less than a week. It was really fast. Yeah. And really cool to see, by the way.   Michael Hingson  52:36 And and they've done it well. Yeah, they have.   Dr. Hoby Wedler  52:39 Yeah. Well, I also serve on the board of the Petaluma Educational Foundation, where basically fund or private foundation funds, grants and scholarships to students all over Petaluma. So I have fun with that, too. More than chemistry,   Michael Hingson  52:53 I hope.   Dr. Hoby Wedler  52:55 We do fund all programs. Yes. Yes, that's right. That's cool. That's fun. It's fun to get out there and be involved.   Michael Hingson  53:04 And that's, that's really it. Right? It's, it's all about having fun and enjoying what you do   Dr. Hoby Wedler  53:10 is because when you do that, it doesn't feel like work.   Michael Hingson  53:14 And an incentive really isn't. Well there any last things you'd like to say any last thoughts you have that you want to leave with people.   Dr. Hoby Wedler  53:22 Don't forget to live life with the most positive mindset you can have. And a great way to feel good about yourself is to challenge yourself and succeed. So I always say, abundance mindset, the more people you know, the better. The more opportunities you have in the world, the better just Just live your life to the best of your ability. And don't forget to have a little fun while you're doing it.   Michael Hingson  53:47 And that makes you unstoppable. And I that's exactly what it's all about. And that makes anyone who does that unstoppable will hope you Wendler, thank you for being with us on unstoppable mindset today. It's been a lot of fun. One more time, how can people reach you and   Dr. Hoby Wedler  54:03 just visit hoby.com That's the best way to get in touch with me. All my contact info is there and there's a contact form. You can find our Hoby's Essentials product line there. You know you see a link right from that website to us. So that's that's the hub for everything.   Michael Hingson  54:24 Cool. Well thank you for being here. And if and if any of you listening will please do so I hope that you'll go to your podcast host or you can go to MichaelHingson.com/podcast that's M I C H A E L H I N G S O N.com slash podcast and give us a five star rating. We would appreciate your ratings and your comments. You're also welcome to reach out. To me. The easiest way is through email. You can email me at MichaelHI  M I C H A E l H I At accessiBe.com. accessiBe is spelled A C C E S S I B E. So Michaelhi@accessibe.com. we'd love to hear from you hear your thoughts what you think about the show. And hopefully you or anyone listening if you think of others who ought to be guests on on the unstoppable mindset podcast would definitely appreciate you letting us know and and suggested many others. Well, great, we we hope that you will fill our calendar with   Dr. Hoby Wedler  55:30 lots of will not be I will not be shy to introduce you.   Michael Hingson  55:33 Please do not be shy and we won't be shy about inviting you back. So well. Thank   Dr. Hoby Wedler  55:38 you very much   Michael Hingson  55:39 me posted and we'll we'll   Dr. Hoby Wedler  55:40 I shall. Thank you, Michael. It's been a pleasure.   Michael Hingson  55:45 Thanks again. Hopefully this has been really fun, which is of course what you want us to do.   55:49 Absolutely. Thank you. Thank you.   Michael Hingson  55:59 You have been listening to the Unstoppable Mindset podcast. Thanks for dropping by. I hope that you'll join us again next week, and in future weeks for upcoming episodes. To subscribe to our podcast and to learn about upcoming episodes, please visit www dot Michael hingson.com slash podcast. Michael Hingson is spelled m i c h a e l h i n g s o n. While you're on the site., please use the form there to recommend people who we ought to interview in upcoming editions of the show. And also, we ask you and urge you to invite your friends to join us in the future. If you know of any one or any organization needing a speaker for an event, please email me at speaker at Michael hingson.com. I appreciate it very much. To learn more about the concept of blinded by fear, please visit www dot Michael hingson.com forward slash blinded by fear and while you're there, feel free to pick up a copy of my free eBook entitled blinded by fear. The unstoppable mindset podcast is provided by access cast an initiative of accessiBe and is sponsored by accessiBe. Please visit www.accessibe.com. accessiBe is spelled a c c e s s i b e. There you can learn all about how you can make your website inclusive for all persons with disabilities and how you can help make the internet fully inclusive by 2025. Thanks again for listening. Please come back and visit us again next week.

Daniel Smith is the co-founder and director of software at Entos.  Daniel holds a Bachelor of Science in Biochemistry and a Ph.D. in computational chemistry. With a passion for science, technology, and software engineering, Daniel has completed research for Georgia Institute of Technology and the Molecular Sciences Software Institute at the Virginia Tech Corporate Research Center, before beginning his journey with Entos. With a presence in our co-working community, COgro, they are working on AI-driven chemistry for medicine. 2015 - Graduated with a Doctor of Philosophy in Computational Chemistry from Auburn University.2010 - Graduated with a Bachelor of Science in biochemistry from the College of Charleston. Worked as a postdoctoral research associate for Georgia Institute of Technology, and worked as a software scientist at The Molecular Science Software institute in Blacksburg, VA. Started at Entos in April of 2020 as co-founder and principal software engineer and is now the director of software. Has a deep passion for computational chemistry, quantum chemistry, education, science, and technology.  

Building on the previous discussion of Hartree-Fock Theory, I discuss the inclusion of basis functions to produce the Roothaan equations, and the method of solving these using self-consistent field methods. I then provide an introduction into techniques to incorporate electron correlation by adding Slater determinants, focusing on the Configuration Interaction method. I then provide a brief overview of semi-empirical methods, Density Functional Theory, and molecular mechanics. Recommended pre-listening is Episode 119: Computational Chemistry Part 1. If you enjoyed the podcast please consider supporting the show by making a PayPal donation or becoming a Patreon supporter. https://www.patreon.com/jamesfodor https://www.paypal.me/ScienceofEverything

An overview of techniques of determining molecular structure, including an introduction to valance bond theory covering bond formation and orbital hybridisation, and a discussion of the basics of molecular orbital theory, covering the basics of the Hartree-Fock method for solving the Schrödinger equation and finding molecular orbitals. In the process I also discuss the Pauli exclusion principle, the effect of electron spin, and the indistinguishability of electrons. If you enjoyed the podcast please consider supporting the show by making a PayPal donation or becoming a Patreon supporter. https://www.patreon.com/jamesfodor https://www.paypal.me/ScienceofEverything

Elisa Fadda obtained her PhD in 2004 from the Department of Chemistry at the Université de Montréal under Professor Dennis R. Salahub. From May 2004 to May 2008, she worked as a post-doctoral fellow in Dr Régis Pomès group in Molecular Structure and Function at the Hospital for Sick Children (Sickkids) Research Institute in Toronto. From June 2008 until May 2013, Elisa worked as a research associate and honorary research lecturer in Prof Robert J. Woods group in the School of Chemistry at NUI Galway. In 2013 she was awarded a Post-Graduate Certificate in Teaching and Learning in Higher Education from the Centre for Learning and Teaching (CELT) at NUI Galway. In August 2013, Elisa became an Assistant Lecturer in the Department of Chemistry at Maynooth University, taking on a Lecturer position since 2014.You will hear the following terms used during the interview. I've included some descriptions here. Quantum chemistry -The branch of chemistry that apply quantum mechanics to chemical systems, including electronic structure, molecular dynamics and Schrödinger equations.Biophysics – And approach to science that applies methods typically used in physics to study biology and biological systems.Glycoproteins – Proteins which contain oligosaccharide chains (glycans), attached to amino acid side-chains via a covalent bond.Carbohydrates – Molecules (typically biological) composed of Carbon, Hydrogen and Oxygen, typically with a 2:1 Hydrogen:Oxygen atom ratio.Glycan (or polysaccharide) – Compounds made of many monosaccharide subunits, linked via a glycoside bond.N-Glycans – Glycans attached to a protein at an Asparagine residue via an N-glycosidic bond.Sequon – A sequence of amino acids in a protein that serve as a carbohydrate binding site.The carbohydrate is often an N-linked-Glycan.Asparagine, proline, serine, threonine. – Amino acids found naturally in biological proteins. Asparagine, serine and threonine are required in specific combinations to form a sequon, proline must be absent from a sequon.Glycosaminoglycans or mucopolysaccharides- Long, linear glucans consisting of repeating disaccharide units – most commonly uronic acid and an amino sugar.Glycosylation – A reaction in which a carbohydrate molecule is attached to a functional group of another molecule (such as a hydroxyl).  In biology the term typically refers to the carbohydrate being attached to a protein molecule.Folded protein – Proteins have several levels of structure, secondary, tertiary (and arguably quaternary) levels of structure describe how the polypeptide chain forms into specific structures that typically confer functional properties.Cryo-EM – Cryogenic Electron Microscopy studies samples cooled to cryogenic temperatures (-153 oC or lower), while embedded in vitreous water.X-Ray crystallography – A technique which uses X-rays to determine crystal structures, but studying the X-ray diffraction patterns.NMR – Nuclear Magnetic Resonance subjects samples to a strong magnetic fields and measures the resonance pattern of the nuclei. It is widely used to study the structure and dynamics of organic molecules.Spike proteins – More properly ‘Peplomers', spike proteins are glycoproteins that project from the surface of a virus particle lipid bilayer and play an important part in viral infectivity.Coronavirus – One of a group of related RNA viruses that cause respiratory tract infections in birds and mammals. These infections lead to diseases that can have mild effects, or be lethal. The Covid-19 pandemic was caused by a coronavirus, the SARS-CoV-2 virus. The 2002/4 SARS outbreak was caused by the SARS-CoV-1 virus.HIV – The Human Immunoseficiency Virus is two species of lentivirus that if left untreated cause Acquired Immunodeficiency Syndrome (AIDS) in humans.Receptor – A protein embedded in a cell membrane which binds to a specific molecule, or class of molecules.  Once the target molecule is bound, there is typically and effect within the cell to trigger some form of biological process.(viral) Pathogensis – The process by which a disease progresses. Viral pathogensis is specific to a disease caused by a virus.Computer node – Each computer in a connected cluster that are working together.GPUs – Graphics Processing Units are specific electronic circuits that rapidly address memory in order to output images to a display device. Their highly parallel structure makes them efficient at processing algorithms that process large data blocks in parallel.Glycoanalytics – Scientific study of glycosylated molecules, often biological in nature.Neuraminidase, or Sialidase – Are enzymes that cut the glycosidic bonds of neuraminic acids. This action helps viruses move through the respiratory tract mucus and infect host cells. The publication we refer to early on in the discussion is available at https://www.sciencedirect.com/science/article/pii/B9780128194751000560?via%3Dihub.  A full list of Elisa's publications is available at her group website. Elisa is contactable on social media, and you can find her on LinkedIn https://www.linkedin.com/in/elisa-fadda-a012b194/ (although, Elisa admits, she's rarely on LinkedIn)On Twitter, search @ElisaTelisaThe group website is https://efadda73.wixsite.com/elisafadda Our theme music is "Wholesome" by Kevin MacLeod (https://incompetech.com)Music from https://filmmusic.ioLicense: CC BY (http://creativecommons.org/licenses/by/4.0/) Connect with me (Paul) at https://www.linkedin.com/in/paulorange/H.E.L. group can be found at www.helgroup.com online,on LinkedIn at https://www.linkedin.com/company/hel-group/ on Twitter, we're @hel_group, https://twitter.com/hel_groupor search for us on Facebook

Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.There are exciting stories of life-changing experiences thanks to science, or through science. And then there is Osvaldo's story. Osvaldo Gutierrez, now assistant professor of chemistry and biochemistry at University of Maryland, could not really foresee his future as an award-winning chemist when, as a child, he left Mexico to move to the United States. This episode tells an inspiring story of personal development through hard work, perseverance and talent – a real and modern American dream. But it's not just a tale of a kid from humble origins becoming an accomplished chemist and a role model for the younger generations, this is also a story of scientific excellence. Paolo and Osvaldo discuss the present and future of catalysis, how base metals such as iron could displace precious metals but also offer novel options for synthetic organic chemists and how combining computational and experimental chemistry is a promising way to gain the fundamental understanding necessary to introduce some much-needed innovations in modern organic synthesis.

Manolo Bellotto, PhD is General Manager and President Gain Therapeutics and dedicated to redefining drug discovery through the use of supercomputers and proprietary algorithms to understand rare diseases and diseases where there is a high medical need related to protein misfolding. These indications include cancer, neurodegenerative, metabolic and inflammatory diseases. While traditional drug discovery around protein misfolding was through high-throughput screening, Gain can efficiently identify a select group of molecules that can potentially correct misfolding or induce misfolding of specific proteins.  In a short period of time, using a personalized approach in each different target, they have the biological characterization to see if they can intervene on the protein, potentially leading to a pharmacological solution. @GainThera #ProteinMisfolding #DrugDiscovery #RareDisease #Oncology #LysosomalStorageDisorders #Neurodegenerative #Supercomputer #technology #ComputationalChemistry GainTherapeutics.com Download the transcript here

Manolo Bellotto, PhD is General Manager and President Gain Therapeutics and dedicated to redefining drug discovery through the use of supercomputers and proprietary algorithms to understand rare diseases and diseases where there is a high medical need related to protein misfolding. These indications include cancer, neurodegenerative, metabolic and inflammatory diseases. While traditional drug discovery around protein misfolding was through high-throughput screening, Gain can efficiently identify a select group of molecules that can potentially correct misfolding or induce misfolding of specific proteins.  In a short period of time, using a personalized approach in each different target, they have the biological characterization to see if they can intervene on the protein, potentially leading to a pharmacological solution. @GainThera #ProteinMisfolding #DrugDiscovery #RareDisease #Oncology #LysosomalStorageDisorders #Neurodegenerative #Supercomputer #technology #ComputationalChemistry GainTherapeutics.com Listen to the podcast here

Caitlin Casey-Stevens (Chemistry PhD student), who was talking about using computational chemistry to study pollutants. Broadcast on OAR 105.4FM Dunedin www.oar.org.nz

Dr. Promit Ray has a PhD in Computational Chemistry from the University of Bonn, and is currently a data engineer at Heartbeat Labs in Berlin, Germany! Promit wasn't actually targeting industry (or a data career for that matter) when entering graduate school. He actually transitioned from bachelor's/ master's experience in experimental chemistry to theoretical chemistry for his PhD, during which an internship at BASF convinced him of the merits of industry. His first full time role in industry was actually in business intelligence, and moved into data engineering soon after. Promit is an amazing example of how one can transform his passions into reality, even as they change over time! And Promit isn't just active at work, but has so many interests outside of work as well! He's interested in science communication, enjoys helping grads transition to industry (https://www.freethephd.com), volunteer caretaker/ mentor of both young (https://feaindia.org) and old (https://humanistisch.de/dongbanja), a music fan, and passionate about chess! Join us as we break down academia, industry, and life in this month's episode! Check out the multi-author scicomm platform co-founded by Promit, Amicable Scientists! https://amicablescientists.org/ - they always welcome contributions and would love to hear from you! :)

In today's podcast we cover four crucial cyber and technology topics, including: 1. Umbraco CMS fixes flaws in API 2. Rockwell Automation finds 9 critical flaws in industrial automation product 3. Chinese-linked actors spying on Vietnam with new malware called FoundCore 4. ForceDAO cryptocurrency platform exploited within days to tune of $367k I'd love feedback, feel free to send your comments and feedback to  | cyberandtechwithmike@gmail.com

Shonda and Gregory explore her 2018 book release entitled, "All of Your Energy is Going to Your Mouth." A self-documentary of the fastest-growing energy thieves of the 21st century - Unproductive conversations. Our special guest today has been a public servant in higher education for over 20 years. She currently serves as the Associate Director for the Center for *Computational Chemistry at Jackson State University. The Center focuses on computational applications to improve health and environmentally related issues. The Center's portfolio, comprised mainly of external government or industry funds, is approximately $15 million. She is the lead facilitator for all research and education components and collaborates with a team of 26 postdocs, faculty, and students. She received her B.A. from Tougaloo College and M.B.A. and Ph.D. (in Higher Education) from Jackson State University. She is a 2010 graduate of the Harvard University Management Development Program and has taught as an adjunct professor in Educational Leadership in the areas of advanced and elementary statistics. She is also certified in Machine Learning and Artificial Intelligence, and Data Analytics from the Massachusetts Institute of Technology and the Association of International Certified Professional Accountants. She is a lifelong learner and believes in keeping cutting-edge educational and research opportunities at the forefront of the Center. Her research and practical management style focus on organizational effectiveness. She is explicitly maximizing the energy of her teams for continuous and fluent improvement. This is an episode that is surely worth exploring every minute of their discussion. Tune in and listen. #kut2thachase #podcast #unscripted #unbridled #episode4everyone #E75 #allofyourenergyisgoingtoyourmouth #satx #sanantonio #sanantoniopodcast #sanantoniopodcaster #sanantonioinfluencer --- Support this podcast: https://anchor.fm/kut2thachase/support

"We think about drug discovery as a learning problem...How can we learn our way from a very early hit molecule to an exquisitely designed, safe, efficacious drug candidate that you're prepared to take into the clinic?" Garry Pairaudeau is the Chief Technology Officer at Exscientia, a company pioneering AI technology in drug discovery. Garry joined us to talk about his career in Medicinal and Computational Chemistry, the marriage of technology and science, how his early experiences in academia shaped his life in industry and the importance of working with great teams. Enjoy!

Dr. Hoby Wedler is the co-founder of Senspoint, which has a sister brand called Tucker Branding, and it is a full-spectrum design company with a distinct focus on telling stories to create truly memorable experiences using all five senses. Dr. Wedler has been completely blind since birth. He is a scientist, a food and beverage expert, and a passionate explorer of anything sensory. Dr. Wedler earned his Ph.D. in Computational Organic Chemistry from the University of California, Davis.  He also founded Accessible Science, a nonprofit organization that held annual chemistry camps for blind or visually impaired students. Dr. Wedler began opening doors to the world of wine aromas by holding truly blind wine tastings in Francis Ford Coppola’s wineries, and he's conducted these all over the globe.  Dr. Wedler was recognized by President Barack Obama in 2012 when he was named a Champion of Change. In this episode… We make a ton of excuses for not doing the best we can, but when you listen to Dr. Hoby Wedler’s story, you will realize that there really should be no room for excuses. Not one. Dr. Wedler is the perfect example of someone who didn’t accept or make excuses. He set the bar high for himself and defied anyone who tried to dictate what he could and couldn’t do. So not only did he major in Chemistry even when people weren’t very encouraging about it, but he actually went ahead and earned a Ph.D. in Computational Chemistry.  According to Dr. Wedler, the secret is to expect the world of yourself and to never let anyone pull you down or box you in. Dr. Wedler exemplifies this belief and approach to life, and he says that his motto is to always challenge yourself to do something that you either dread doing or think you can’t do, and just take baby steps and you’ll get there. Tune in to this episode of Inspired Insider Podcast with Dr. Jeremy Weisz as he talks with Senspoint co-founder, Dr. Hoby Wedler, about his inspiring story and why he believes that making excuses can pull you back instead of pushing you up. Dr. Wedler also shares some of the remarkable things that Senspoint has worked on, what it was like for the attendees of his blind wine tasting in the Francis Ford Coppola wineries, and how his parents helped him understand the value of setting the bar high.

Katarina Brlec je doktorska študentka na področju Computational Chemistry na UCLu v Londonu. Pred tem je na isti univerzi opravila dodiplomski študij kemije. V tej epizodi sva se pogovarjala o celotni poti iz Slovenije do masterja in začetka doktorata. Zakaj se odločila za doktorat in ne za kariero pri Deloittu, kjer je imela ponujeno službo? Zakaj prav computational kemija? Kaj pravzaprav počne kot doktorska študentka? Prijetno poslušanje!

Dr Hannah Bruce Macdonald is a Research Fellow in the Chodera Lab at Memorial Sloan Kettering Cancer Center. Hannah researches free energy methods for applications in drug design. In this episode we discuss, how are free energy calculations used in drug discovery? And how important are computational methods for modern drug synthesis? Twitter - https://twitter.com/hannahbruce

Dr Evelyne Deplazes (tw: @DeplazesEvelyne) is a biophysical and computational chemist who is fascinated by the molecular world. Her research is driven by her passion for science and her innate curiosity to 'solve puzzles'. Evelyne is a Chancellor's Research Fellow at the University of Technology Sydney and together with other researchers, runs the UTS Membrane biophysics group. In her research, Evelyne uses Australia's largest supercomputers as well as lab-based experiments to understand how small molecules interact with the surface of cells. This includes studying how chemical compounds found in venomous animals, plants, or honey interacts with cell membranes. The knowledge from her research helps other scientists to develop new pharmaceuticals or understand how drugs enter cells. Apart from her research, she is passionate about supporting diversity and equity in STEM and teaching the next generation of scientists to be 'critical thinkers'. She also tries to integrate her yoga practice of kindness and gratitude into how she leads her research team. In our conversation, we talk about her journey to computational chemistry, her research on honey and spider venoms in membrane biophysics, academic career development, and yoga. Show Notes (link) Connect with STEAM Powered: Website Facebook Instagram Twitter Patreon Ko-Fi

In which Vaibhav and Dr. Stockwell talk about how using small molecule screening helped uncover pioneering details about Iron influenced cell death (Ferroptosis), the therapeutic context for Ferroptosis, and ligand prediction with computational chemistry. They conclude with some discussion about Dr. Stockwell's current collaborative SARS-CoV2 antiviral efforts.

In this edition of the SpheraNOW podcast, James Tehrani, Spark's editor in chief speaks with Dr. Adrian Mulholland, a chemistry professor at the University of Bristol’s Centre for Computational Chemistry in England, about the VR technology he and his team are developing to research anti-viral medications for COVID-19 and other diseases.

Episode Notes: A collaborative team is working to get NWChem ready to run on exascale machines and to provide a starting point for future code development.

What's good beautiful humans!I'm very excited to share this mind-melter of an episode with you all! My guest this week is Dr. David Glowacki: scientist, artist and cultural theorist. Dr. Glowacki has appointments as a Research Fellow at the Royal Society scientific academy in the UK and as a Philip Leverhulme Fellow at the University of Bristol. Dr. Glowacki was so gracious to come on the BNP and talk to us about his current work creating virtual reality environments in order to induce mystical-like experiences similar to what one experiences on the psychedelic journey, for the purpose of healing and treating depression, addiction and PTSD. Dr. Glowacki heads up "an eclectic academic research group called the ‘Intangible Realities Laboratory’ (IRL), which is joint between the Centre for Computational Chemistry and the Department of Computer Science." He has "published in several domains: non-equilibrium molecular physics, classical & quantum dynamics, biochemistry, digital aesthetics, interactive art, human-computer interaction, high-performance computing & algorithm development, evolutionary algorithms, religion & power, cultural theory, atmospheric physics, optics, and scientific instrument development." Dr. David Glowacki is an absolutely brilliant thinker and an eloquent speaker, and it was a real blessing to have him on Barbarian Noetics. Check out his website to learn more about his work, background, and current projects at https://glow-wacky.com/.So strap in and come along as we journey into an exploration of the Intangible Realities that underpin our reality. Enjoy this episode, and don't forget to rate, review and spread the word about the BNP. Much love y'all,ConanTRACK LIST FOR THIS EPISODEDykotomi - Corvid Crunk (Official Intro Track for the BNP)dryhope - White OakGaudi - Ayahuasca Deep DubDelirium - Silence (feat. Sarah McLachlan)David Starfire - Primal (Zebbler Encanti Experience Remix)Zion I - What We Gone Do (feat. Jane Hancock)Support the show (http://www.patreon.com/noetics)

In this episode of the Inside AutoAlert podcast, we talk to one of AutoAlert’s doctors. He’s not a medical doctor, but Data Scientist Jeff Christianson does have his PhD in Computational Chemistry. Jeff blows our minds and melts our faces by explaining what exactly data science is. Plus, “The DALSKI”, Randell Horn- Senior Director of Sales Operations, sits down and dives into what the AutoAlert save team does. Then, he educates us on the dunes of Oklahoma and Missouri country living.

Machine learning is becoming a bigger part of chemistry as of the last two or three years. Industries need to have people trained in both fields, and it's taken time for them to make their way into this sector. Olexandr Isayev is at the forefront of that wave, and he talks to us about what he's done while melding deep learning and chemistry together and his vision of where he sees this field going with this new tech.

Deep learning has helped machines understand how to move pieces around a board to master, and win, Go, the most complicated game mankind has ever invented. Now it's helping a new generation of chemists better understand how to move molecules around to model new kinds of materials. Our guest, Olexandr Isayev, an assistant professor at the UNC Eshelman School of Pharmacy, at the University of North Carolina at Chapel Hill, joined our show to explain how deep learning, Go, sci-fi, and computational chemistry intersect.

Nick Nystrom Director of Strategic Applications, Pittsburgh Supercomputing Center   Bridges: Connecting Researchers, Big Data, and High-Performance Computing   Follow along with the slides HERE! Inferring the causes of disease, tracking the survival of the human race, and enabling natural-language searches of video are just a few of the topics being tackled right here in Pittsburgh at the Pittsburgh Supercomputing Center. Join us as we explore how the center uses big data and data analytics to better understand challenging problems. As the center's Director of Strategic Applications, Dr. Nick Nystrom and his team develop hardware and software architectures to enable groundbreaking research, engaging in research and collaborations across diverse disciplines. At Café Sci, Nystrom will discuss researchers' use of PSC's newest resources, including "Bridges." "Bridges" is a data-intensive high-performance computing (HPC) system designed to empower new research communities, bring desktop convenience to HPC, expand campus access, and help researchers facing challenges in Big Data to work more intuitively. Funded by a $9.65 million National Science Foundation award, Bridges consists of three tiers of large-shared-memory resources, dedicated nodes for database, web, and data transfer purposes, high-performance shared and distributed data storage, powerful new CPUs and GPUs, and the new, uniquely powerful interconnection network. From a software perspective, Bridges supports widely-used data analytic software such as R, Java, Python, and MATLAB, integration of Spark and Hadoop with HPC, and virtualization. Nystrom will discuss the importance of converging Big Data and HPC and how Bridges is bringing HPC to nontraditional users and research communities. Nystrom is also a research physicist in the Department of Physics at Carnegie Mellon University. He earned his bachelor’s degree in Chemistry, Math, and Physics and a PhD in Computational Chemistry from the University of Pittsburgh.   Recorded on Monday, March 7, 2016 at Carnegie Science Center in Pittsburgh, PA.

Dr. Burke is Professor, Heretical Physical and Computational Chemistry, in UC-Irvine's School of Physical Sciences. His research interests include theoretical chemistry, theoretical physics, math, and computation. His lecture was given on September 2, 2011.

Huge problems of energy and sustainability confront the science/engineering community, mankind, and our planet. The energy problem comes in many dimensions, including supply, demand, conservation, transportation, and storage. This overview will stress the nature of these problems, and offer a few areas where theoretical chemistry can make substantial contributions to solving them. Also discussed are excitons in solar cells and on advanced batteries.