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aBlogtoWatch Weekly is back on the main aBlogtoWatch YouTube channel with new releases every Friday!- https://www.youtube.com/@ablogtowatch This week on aBlogtoWatch Weekly, Rick and Ariel are holding down the fort without David and Ripley, which means the conversation quickly goes off the rails before diving headfirst into the latest watch industry news. The duo discuss the new Raymond Weil ART and ask the big question: is it a genuinely compelling integrated bracelet watch or just another trend follower? They also debate the rise of integrated bracelet sports watches, micro rotors, and why some brands are chasing familiar formulas while others are trying something completely different.Plus, there are thoughts on Bell & Ross leaning into modern art inspired design with its latest cubist inspired release, the new TAG Heuer Monaco Speed and its unusual jumping hour display, and whether square watches deserve more love or just more confusion. Along the way, Rick and Ariel somehow find time to argue about sleeping with watches on, lume at 3AM, AI frustrations, and why Bell & Ross might just need its big Hollywood moment. It is exactly the kind of wonderfully chaotic watch conversation you expect from an aBlogtoWatch Weekly podcast with just Rick and Ariel. To check out the ABTW Shop, where you can see our products inspired by our love of Horology:- Shop ABTW - https://store.ablogtowatch.com/To keep updated with everything Superlative, aBlogtoWatch Weekly, and aBlogtoWatch, check us out on:- Instagram - https://www.instagram.com/ablogtowatch/- Website - https://www.ablogtowatch.com/- Facebook - https://www.facebook.com/aBlogtoWatch If you enjoy the show please Subscribe, Rate, and Review!Key Timestamps:[04:07] Sleeping With Watches?[07:14] Why Ariel & Rick Go Off Track[11:45] Raymond Weil A.R.T. — Hit or Fad?[17:10] AI Art, QR Codes & Tech Frustrations[21:27] Indie Watch Brands & Retail Challenges[27:29] Bell & Ross Cubism & Micro Rotors[38:47] TAG Heuer Monaco Speed 12 Debate[45:29] Swatch “Royal Pop” Queue Chaos[48:15] Camp Watches & Microbrand Realities[51:19] What Actually Counts As A Square Watch?[54:49] ATI ZDM Enigma & Strange Design Choices[56:49] Forgotten Fashion Watches[59:49] The Return Of Fashion Watches?[1:03:04] A Deep Dive Into Versace Watches[1:05:57] The “Punishment Watch” Game[1:08:00] eBay Authentication Experiment[1:09:20] Wrap Up & Next Week's Challenge

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Welcome to LIFTS, where we explore the future of fitness, wellness, and human performance. In this episode, hosts Matthew Januszek and Mohammed Iqbal are joined by Mark Hartnett-Morgan (ATHX Games), Nicolas Denby (GymSync), Emily Leroux (DEKA International), and George Crook (HYROX Training Zones) to explore one of the most significant trends reshaping the fitness industry today: the rise of competition fitness. What started as a niche category has rapidly evolved into a global movement. HYROX events are selling out around the world, DEKA continues to expand internationally, and more operators are beginning to rethink how they design facilities, build communities, and engage members through performance-driven experiences. This conversation explores whether competition fitness is simply another industry trend or a fundamental shift in consumer behaviour that will permanently influence the future of gyms, fitness clubs, and training facilities. The panel examines how competition-based formats are creating new opportunities for operators to drive member acquisition, improve retention, strengthen community, and provide members with measurable goals beyond traditional fitness programming. The discussion also dives into the evolution of fitness events, the growth of dedicated competition training spaces, and the increasing role that challenges, races, and performance experiences play in motivating members to stay engaged over the long term. The guests share insights from ATHX, DEKA, HYROX, and GymSync, discussing how operators can successfully integrate competition fitness into their businesses without losing sight of the broader member experience. For fitness operators, gym owners, investors, coaches, and industry leaders, this episode offers valuable insight into one of the fastest-growing movements in the fitness industry and what it could mean for the future of gym design, programming, and member engagement. In this episode, we cover: Why competition fitness is growing so rapidly The HYROX effect and its impact on gyms worldwide Whether competition fitness is a fad or a long-term movement How events drive member acquisition and retention Why operators may need a competition fitness strategy The future of training zones, fitness tourism, and performance communities

FAD gets started with the Show Open, a heated debate on Christian Watson, and reactions to Brian Schottenheimer audio

Extra Credit on Geography, TOLOs call in for Faddies on the Fones, and can FAD go 82-0?

“Every woman deserves the chance to have a real discussion about hormone therapy — and make whatever decision is right for her. I'm here to give information and answer questions. It's your body.”— Dr. Jacqueline RiedelThe doctor who finally has time for youDr. Jacqueline Riedel, DO spent 15 years in family medicine where she learned this: women's hormonal health in midlife was profoundly under-treated and misunderstood. In a busy hospital-based clinic, she'd start a long-overdue conversation with a patient about perimenopause symptoms… and have to cut it off because the schedule demanded it.So she left. She opened Magnolia Midlife Women's Health, a direct-care practice built on something simple but radical: unhurried, conversational visits where women can actually ask their questions, get real answers, and leave feeling seen.In this conversation, she covers what's really happening hormonally in your 30s, 40s, and 50s and why everything you were told to fear about hormone therapy probably isn't the full story.Perimenopause starts earlier than you thinkDr. Riedel sees women with perimenopause symptoms long before any changes in the menstrual cycle. If you've been dismissed, or told your symptoms are just stress or mom-brain, you're not alone. Symptoms she commonly sees:• New insomnia: can't fall asleep or waking for no apparent reason• Anxiety, often misread as “just life stress”• Persistent, unexplained fatigue• Hot flashes and night sweats• Mood changes including irritability, low mood, brain fog• Cycle irregularities such as heavier periods, irregular timingDr. Riedel's approach: map symptoms to your cycle. When do they happen? Are there patterns? She also rules out other common causes, including thyroid issues and iron deficiency before exploring hormone therapy as an option.MYTH BUSTINGThe fears holding women back from reliefTwo decades after the Women's Health Initiative (WHI) study was misread and sensationalized, fear still dominates the conversation around hormone therapy. Dr. Riedel sets the record straight.Myth 1: Hormone therapy causes breast cancer.Fact: Long-term WHI follow-up showed women in the hormone treatment group had lower rates of breast cancer. Even a first-degree family history is not a contraindication. And if breast cancer does occur in someone using MHT, their risk of dying is actually lower than in those not using it.Myth 2: The doses in MHT are dangerously high.Fact: Menopausal hormone therapy doses are far lower than those in oral contraceptive pills. If you'd prescribe the pill, you can't logically call MHT dangerous.Myth 3: Vaginal estrogen has systemic effects and should be avoided in cancer history.Fact: Topical vaginal estrogen has negligible systemic absorption. It reduces UTIs, yeast infections, urinary frequency, and pelvic floor dysfunction, even in women under active breast cancer treatment, per emerging oncology research. The FDA recently removed the black-box warning.TREATMENT OVERVIEWHow Dr. Riedel approaches careThere's no single protocol. Dr. Riedel listens first, identifying the top two or three symptoms most affecting quality of life, and builds from there.Progesterone for sleep & anxiety• Stimulates GABA production, a calming neurotransmitter• Helps with sleep onset and staying asleep• Reduces the racing mind at 2am• Often the first place she startsEstrogen for vasomotor symptoms• Addresses night sweats, hot flashes, palpitations• Keeps estrogen levels from dropping to “empty”• Preferred as transdermal (patch, gel, spray) to avoid blood clot risk• Added when progesterone alone isn't enoughVaginal estrogen for urogenital health• Reduces painful intercourse and dryness• Decreases UTIs and yeast infections• Supports pelvic floor health long-term• About 50% of women need this even on systemic estrogenNon-hormonal options when hormones aren't right• Newer medications targeting particular neurons in the hypothalamus (hot flash regulation)Things you can do and questions to askDr. Riedel's conversation offers practical starting points for women navigating this transition on their own or with a provider.01. Track your symptoms in relation to your cycleSleep disruption, anxiety, and mood changes that follow a cyclic pattern are often hormonal in origin. Note when in your cycle you feel worst because this information is gold for any provider visit.02. Ask your doctor to rule out thyroid and iron firstFatigue, brain fog, and sleep issues can also come from iron deficiency or thyroid dysfunction. Simple labs can clarify what you're actually dealing with before hormones enter the picture.03. Reconsider what's in your sleep toolkitAlcohol before bed worsens sleep, hot flashes, and anxiety, even though it feels like it helps. Benadryl/ZQuil, Ambien, and benzodiazepines disrupt true sleep architecture. CBT for insomnia has strong evidence and virtually zero side effects. 06. Consider this a second puberty — not a declineMidlife is a genuine developmental threshold. Dr. Riedel and Margaret Mead's concept of “postmenopausal zest” both point in the same direction: this can be a time of clarity, reclaimed energy, and real possibility if you get the support your body actually needs.REFERENCES & RESOURCES[Podcast] Kelly Casperson, MD — You Are Not BrokenUrologist and leading voice in the menopause space. Dr. Riedel's “gateway” into this field. Highly recommended for patients and providers alike.[Course] Rachel Rubin, MD — Physician Webinar SeriesSex medicine specialist and urologist based in Washington, D.C. Physician-only course covering the science of hormones, common fears, and evidence-based prescribing. Her tagline: “What are you afraid of?”[Course] Heather Hirsch, MD — Menopause EducationA well-regarded course for providers wanting to build competence in this space.[Organization] The Menopause Society (formerly NAMS)Membership, certification exam, slide decks, and a comprehensive textbook. menopause.org[Supplement Review] Labdoor.comIndependent third-party testing of supplement brands for purity and label accuracy.FIND DR. RIEDELMagnolia Midlife Women's HealthA direct-care practice built for women who are tired of feeling rushed, dismissed, and underserved. Long visits. Real conversations. Evidence-based care from a physician who actually gets it.Free 15-min consult Not sure if you need this kind of care? Book a quick call to talk through your symptoms and see if Magnolia is the right fit.Website: magnoliamidlife.comInstagram: @magnolia_midlifeUpcoming Event — June 30 Free public lecture at the Haddonfield Public Library: “Is It a Fad?” An evening on perimenopause, evidence, and what women deserve to know. Register through the library website.Thanks for reading A Mind of Her Own! This post is public so feel free to share it.

Right now, high-protein diets are hot and cheese is still the biggest user of U.S. dairy. But will it last? In this episode of The Milk Check, we pull out our crystal balls and try to see into the future of U.S. dairy. Why GLP-1 may be a catalyst, not the whole protein story How health and wellness trends are reshaping dairy demand How exports could change the future of cheese demand The consensus? Find out in The Milk Check episode 100: Is Protein a Fad, and Is Cheese Still King? Got questions? We'd love to hear them. Submit below, and we might answer it on the show. Ask The Milk Check Transcript: Ted Jacoby III: [00:00:00] Coming up on the Milk Check. The debate is: have GLP-1s changed dairy forever? Our second debate is will cheese remain king? Welcome to the Milk Check from T.C. Jacoby & Co., your complete guide to dairy markets, from the milking parlor to the supermarket shelf. I’m Ted Jacoby. Let’s dive in. Ted Jacoby III: Excited for our topic today. We are going to have a debate. The debate is: have GLP-1s changed dairy forever? The demand for protein right now is clearly extremely strong. It’s really a question of whether we think this demand for protein is a fad, or we think it’s a fundamental shift in demand that’s gonna be with us for a long time. And so I’m gonna actually put Mike Brown on the spot first. Mike, has GLP-1s changed dairy forever? Mike Brown: It certainly changed me forever. And I’m a big eater dairy for a long time. I’ve had good success with GLP’s getting my weight to where it needs to be, and one thing you do discover is that you do need to really watch your protein intake. You need to make sure you’re getting adequate amounts because you will lose muscle. I think diets in general, we’re becoming less carb-focused. We’re becoming more protein-focused. So, I don’t see it going away. Does that mean we’ll have the record-high prices we have now forever? Probably not the markets will stay strong, and I think it’s a shift in consumer demand . You just need to go into any Costco or Sam’s Club, and the amount of protein beverages they offer now versus three years ago, they’ve tripled in some cases. So, it’s definitely a market of strength. And despite the high price of proteins, people still seem to be buying it. I’ll see limits when there’s sales in different stores, which tells you that demand is still extremely strong. Ted Jacoby III: Josh, I’ll ask you next. Are we changing demand forever, or is this a fad? Josh White: I don’t know that GLP-1s are necessarily what’s changing demand forever, but they definitely are a catalyst and a disruptor right now. We were listening to a HighGround Monthly Update earlier today. I’ll echo something that was said during that update: A health and wellness trend [00:02:00] is absolutely happening, is global. They noted and cited in that, that over the last two years, gym memberships have been up in the U.S. If you go to other parts of the world that we export products to that GLP-1s haven’t yet reached, we’re seeing incredible health and wellness movements and protein consumption uptake. So, what I think the GLP-1 aspect of it is doing is that it served as a bit of a catalyst and ignited this market and forced us all to recognize this shift that we’re seeing from just calories taken in to quality of calories taken in, and that is driving a lot of incremental protein demand that the dairy space is a benefactor of to date. So, I don’t know if I really answered it, Ted. I think GLP-1 is a catalyst in forcing us to recognize a bigger trend that we’re seeing, not only in the U.S., but globally. Jacob Menge: I do think it’s pretty important to talk about the time horizon that we’re discussing because there’s a really big difference in both availability and dietary preference of protein sources globally, right? Like India, Sub-Saharan Africa, even China up until very recently was very plant protein-based. And so, even though protein consumption as a whole has certainly been growing where you are looking at depends on how much that’s actually impacting animal proteins. And so, I think that time horizon is important, right? Because we know where population growth is occurring worldwide. Population growth worldwide is actually in areas that are plant protein consumers not animal protein consumers . And you’re getting some animal protein consumers actually trending lower on population, right? You look at the population outlook for a lot of Europe. Korea was in the middle. I think they’re, like, 50/50, if I recall, on plant versus animal proteins. But I think that time horizon is a pretty important piece of the discussion. Ted Jacoby III: So Jake, I’ll ask you the [00:04:00] question. So, five years from now, are we gonna be looking back on 2025 and 2026 and talk about the whey protein fad, or do we think that we will have seen a fundamental shift in where people have invested their investment dollars in terms of what kind of dairy production facilities, processing facilities have been built in the U.S. and around the world? Jacob Menge: Five years is way too short of a timeline to see what I would call a freight train changing its course. And so, I think that’s pretty clear. We know what’s gonna be happening with U.S. exports, right? We are just set up to be the export powerhouse in the short term, and I would call five years short term for trends like this. Even though this has happened very fast, knowing again what is happening with the U.S. export picture, I don’t think there’s any way we see a material change in what’s happening in the protein space in a five-year period. Mike Brown: I think there’s one point of difference in milk proteins versus whey proteins. I think we see, because of cost difference, I think, more interest in finding, how can I use milk proteins in a product versus whey? I noticed this weekend, again, looking at a sports beverage that 30 gram protein, number one ingredient’s milk, and it’s not a fairlife(R) product. It’s an amalgamated product. Jacob Menge: Couldn’t agree more. I was certainly one level higher in just saying any dairy protein or animal protein for that matter. But yeah, when you drill down, do I think there could be shifts within that makeup? Absolutely. Mike Brown: The other thing is with whey proteins is that you gotta sell the cheese or you gotta sell the casein. And as we look at that spread in price, what’s that value of that whey protein worth versus what you get for the remaining part of the product? As we know, right now, Class IV, which is even dry milk powders and fat are worth way, way more than milk for cheese, even when you adjust for the higher protein revenues. We have a $5 spread right now between Class III and Class IV. And that always takes care of itself, but exactly how it will, I think we all know there’s interest in do I add casein-producing capacity so I [00:06:00] can get to my whey proteins rather than just cheese? If I make those caseins, where’s the market for those products? Where am I gonna be able to use them? So I think there’s lots of questions that we don’t know yet. ‘Cause if I’m a processor, one very high-value product, whether if it’s a half a pound or three-quarter of a pound yield per 100 pounds of milk, it’s not gonna drive all your decisions. It’s gonna be a factor. Ted Jacoby III: Gus, I’m gonna ask you the question: Has GLP-1 changed dairy forever? Or do you think it’s a trend? Gus Jacoby: I’m of the impression that we are certainly following the trends within Western culture to evaluate more and more the health benefits of eating better nutrition. And certainly, as time moves on, the protein component in your meal is going to be more and more important. So, I’m not going to take away from that. I think that will continue to evolve, but I also think that as we continue to evolve in that setting, other pieces of that nutrition will come to light and become the fad for a period of time. At the moment, protein is hot, and I don’t think we can get away from that. For me, just looking at U.S. milk production and how much of that milk production goes into cheese ,the ever-increasing demand in cheese, I don’t see that going away either. I think that’s an entrenched part of our society, and I think cheese is a pretty important part of the daily food consumption here in our culture as well.  I think there’s a place for both of them, and it’s hard for me to distinguish one from the other as being where we go as an industry. Mike Brown: One thing we may see is more of these protein-based dairy beverages that aren’t Class I milk take more and more of that consumer stomach. And so, we’re gonna see more of those UF-based products, which aren’t necessarily what we think of traditionally as fluid milk. And that’s where a lot of the growth has been: in the high-protein milks. Is that where the substitution will take place as much as in some other ways? Gus Jacoby: I don’t think there’s any doubt, Mike, but I would also argue that we’re probably going to eat into that Class I consumption a bit by more of this dairy protein shake, which tends to be in the [00:08:00] Class II area. Mike Brown: Yeah, that’s, and that’s what I, that’s what I meant. Yeah. Okay. If you’re gonna drink it as a Class II product, it all gets down to how regulation basically makes those products more competitive- Yeah … because of the regulated minimum price. Gus Jacoby: That would be a very Interesting discussion probably for another day relative to- what we wanna cover in our debate today. Mike Brown: Yeah. It’s a bit of a nerd fest, But we look at consumption trends, it isn’t hurting the high-protein products because they are priced differently. Gus Jacoby: Yep. Ted Jacoby III: Diego, what are your thoughts? This demand for protein: fad or a long-term trend? Diego Carvallo: I think the trend is clear, and it still has a lot of room to grow. So, I think in a five-year period, it’s very easy to say that they’re gonna continue to grow. Ted Jacoby III: You see the international space a lot more clearly than most of the rest of us. What’s happening here in the U.S., is it happening internationally as well? Diego Carvallo: Yes, and that’s why I said that there’s gonna be growth ’cause I still see areas of Latin America where that trend is just getting started . You still do not see any of the products that you’re seeing in the U.S. at the supermarket showcasing and showing marketing that much the protein content on the end product. So I think that growth is still getting started. Ted Jacoby III: Joe, last but not least, fad, long-term trend? Joe Maixner: I think that the consumer shift is a long-term trend. I don’t know if necessarily the GLP-1 is the long-term trend because technology will continue to advance, and there’ll be something that comes out at some point that makes this old news. I think that the health and wellness trend is certainly here for the foreseeable future. estimating 40 million people within the next five years are going to be on GLP-1s. That’s a big number. The one thing we’ve seen the effect on selfishly for my market is the amount of cream and fat that it’s spun off because of all the demand for the protein. We did not expect to have this fundamental shift in the fat market domestically this quickly. Unless the farmers decide that they’re gonna change how they feed their cows and produce less fat, we’re gonna see that for a while too, and we’re gonna be surplus fat. And that [00:10:00] product is also affected by this GLP-1 because people tend to eat less sweets and snacks and fat-heavy products, so consumption’s been down on that side as well. Ted Jacoby III: It’s gonna be interesting. And I’ll just give my two cents. I do think the demand for protein is a long-term trend. I think it’s a trend both within certain segments of the population and I think it’s a trend in that I think, just comparing my generation and how I ate and drank in my 20s compared to how my children eat and drink in their 20s, they sure do live a healthier life than I did when I was that age. I think I’m speaking for a good portion of that generation and not just my kids. So, we’ll see. It sounds to me that the consensus is pretty clear on this one. Whether it’s GLP-1s or not, this protein trend is a long-term trend, and it is fundamentally changing the dairy industry. And we’re all curious to see how it’ll play out. All right, now I’m gonna switch to our second debate. This debate is will cheese remain king? So in my lifetime, milk production, when I was born, milk production was roughly 20% of milk was made into cheese. Today, it’s 55%. It is very clear that the driver in dairy consumption in the United States is a per capita increase in cheese that is part of a long-term trend. My question for everybody today is: Have we started to reach the point where that trend is starting to plateau? Is cheese still king? Will it continue to be the driver of increases in per capita dairy consumption, or have we reached a point where we’re not going to see cheese driving the bus anymore? It’s 55% of milk production goes into cheese today. Is it gonna be 65% in 10 years, or is it still gonna be in the 50s? Gus, I’m gonna throw you out there first. What are your thoughts? Gus Jacoby: I think it’s hard to say that it isn’t still king considering the large amount of milk in U.S. milk production that goes into cheese. And even with respect to the protein segment that we just talked about, you can’t make whey [00:12:00] without making cheese, so you’re not gonna get whey protein without cheese. I don’t think the American consumer is going to lose their appetite for cheese anytime soon. I understand that certainly with the GLP-1s we’re gonna eat a bit healthier. But I find it hard to believe that while maybe the growth might become less than it has been over the last number of years I do believe that cheese is gonna be with us as the majority taker of milk at least for the foreseeable future. Ted Jacoby III: Do you think the trend is strong enough that 15 years from now 65% or 70% of all milk goes into cheese? Or do you think maybe we’re gonna plateau right around here at 55%? Gus Jacoby: I think it still has room to go a little bit higher. I think there’s a possibility of plateauing, though maybe at some point north of 60. But at the end of the day I just don’t see how it can be removed from the diet. If people wanna start playing with what type of cheeses are in their diet for better health benefits, I guess that may happen. Ted Jacoby III: All right. Gus Jacoby: Not in the near term. Ted Jacoby III: Jake, what are your thoughts? Jacob Menge: I would imagine that the percent of milk that is turned into cheese goes lower. That’s my gut feel. We’re gonna be export-dominated. We maybe can capture some markets that we haven’t historically gotten into before with more shelf-stable products. We’re just gonna have to export a lot of product. And cheese is exportable obviously, but it just feels, with the new markets we’re gonna be moving into, the amount of product as a percent that we’re gonna be exporting, dietary shifts, it all points to me that, as a percent, it’s hard for me to make the case that cheese goes higher. And so by default , I’ll argue it goes lower. Ted Jacoby III: Joe, what are your thoughts? Joe Maixner: I think that what happens with cheese moving forward depends on how well the dairy industry markets cheese moving forward. If we do a better job of [00:14:00] marketing the protein benefits, the fact that it’s the cheapest protein per gram and playing into those strengths that would help keep it as king and increase consumption. If we continue to sit on our laurels and not really do any additional marketing, I think that we have a chance to lose capacity. Jacob Menge: So what’s your gut? Do we do a good job marketing it or not? Joe Maixner: Okay. I don’t think we do. But we could. The potential is there. We just, we’re not doing it. Ted Jacoby III: I think dairy has struggled for a long time just to market itself as how healthy it is, and some of that I think is because we sit in a position of strength in the marketplace, and so everybody’s always coming after dairy to say they’re better than dairy and dairy’s got issues. So all the plant guys can grow their plant-based products. All of those food products that don’t come from dairy tend to attack dairy in order to grow their own market share. And I think that’s why dairy struggles. I think your point about how the value of a gram of protein in cheese is a lot less than the same cost of that protein, let’s say, in whey powder or in other things. I’m curious to see how that plays out, because I think it’s a really good point. Mike Brown: I’d make a point on the competition. Where we’ve seen shrinkage in the refrigerator dairy case is the non-dairy beverages. They are losing market share. Milks are doing better, particularly the protein milks, are doing so much better. I think there’s still potential, so we can’t assume that. I also think there’s two questions on cheese to me: market share and total market. I think total market still has a little room to grow. I think market share will not grow, maybe decline modestly, and that’s more because of the Class II demand for proteins now with yogurt, Greek yogurts, and cottage cheese, and all the Class II-based liquid beverages. So, it’s more of an issue perhaps of market share, and that takes time to build capacity. We all know that. But the demand is there. Cheese is gonna continue. We [00:16:00] look at the supermarket sales data, it’s still growing modestly, as is butter, and that’s just total sales. I think the other factor we gotta think about here is population growth because our growth’s gonna be much slower. With current immigration policies, I don’t see a quick turnaround in growth of population like we’ve experienced in the past. A lot of that from folks who are big users of dairy in their diet. In the benefit of cheese, as we get older, we drink less, and we eat more milk proteins, and that’s part of our growth, of course, with cheese. The other one is food service. It’s huge, particularly the mozzarella side of the business, and it’s looking pretty tepid right now. That tends to go with health of the economy. I expect it’ll rebound again when people have more money to spend. I think that’s part of it, too. So, cheese is gonna remain strong. Jake made a very good point, though, as did Joe. It’s kinda sold itself, and we’ve had no trouble selling it. We are now the export market, kinda like we did with non-fat dry milk, what, 20 years ago, Josh? We’re, and we’re dependent on that export market. So, it makes us more vulnerable to world price, term, but it also means it’s a chance to grow if our industry adapts to meet those demands. And as we see, everything from powders to butter to cheese, the industry is working on that. But it’s a slow process, ’cause it’s always been that market when we have a little extra it was an opportunistic market, now it’s becoming part of sales strategy, and that’s a very different way to look at your business. Ted Jacoby III: Yeah. It means It’s really matured. Mike Brown: Yes, a lot. Ted Jacoby III: Diego, what are your thoughts? I know you’re not the cheese guy, you’re more of the ingredient guy, but internationally, cheese is definitely growing. Cheese gonna remain king? Or is the other protein sources gonna take over and pull milk away from cheese? Diego Carvallo: So I have contradicting thoughts here. I think that everybody here agrees that the demand for WPCs and WPIs is gonna continue growing, and that’s definitely been making cheese plants very profitable . But at the same time, I’m seeing that many cheese plants being built in the past few years that I think that [00:18:00] the competition is gonna get fierce in that aspect. I would say in the coming years, I see more probabilities of people who build, and companies who build dryers, for example, for non-fat and skim , to have an advantage and definitely a good incentive. Ted Jacoby III: So my two cents is this: I think we are underestimating how much the export demand for cheese is gonna keep driving it. There’s a lot of proof that cheese consumption in developing countries tends to follow a generation or two after milk powder consumption. It starts with infant formula, then tends to stay in the diet as they get older, and eventually manifests itself in cheese, mostly as an ingredient in something like pizzas or burgers, et cetera. And so, I do think cheese demand for cheese out of the U.S. will continue to grow. I do think the curve will flatten a little bit. I also think that you are going to get a continued pressure to build more cheese plants just so you have access to the whey protein, because I think the whey protein is gonna maintain its value. But I’m a little bit like Diego, ’cause on the other side, one of my thoughts is I hear a lot of conversations lately about instead of making cheese, what if we make micellar casein and we pull the native whey, and then we dry the native whey separately? So, I can also see technology continuing to evolve where maybe you don’t actually need to make cheese in order to have access to the whey proteins, and I think we have to keep our eye on that. But I do think cheese is the dominant use for milk in the United States. I don’t see that changing anytime soon, but I do think the trend is probably gonna start to slow down a bit. Josh? What are your thoughts? Josh White: I’m gonna step back a bit and start with one belief, and that belief is that United States dairy economies of scale have now reached a point where we’re gonna grow in our market share for the global dairy consumption. We’re gonna continue to grow in our participation in that business, and we will capture more market share. And if you believe that, at its core, cheese is maybe one of the… If not, it’s the most calorie-dense product that we have. [00:20:00] And there’s an argument that it goes into products as both ingredients and as the primary food service or retail product, which accesses a lot of different demand potential. If you think about the cheese factory, maybe not how they’re run today, but if you think about it, I’ve made the mistake multiple times of saying that we’re gonna start balancing to cheese, and there’s been a big argument about that, internally. And I can understand why there’s an argument on the surface level. But in the bigger picture, it’s what may be the most versatile way to process milk and balance out whether we have extra protein, extra fat, or we’re short of either of those product or whatnot. You can spin off more cream. You can bring in more solids. You really optimize that recipe, and I feel like that makes it foundational. And if it’s foundational, you’re gonna continue to see investment in these large cheese plants. If whey protein’s hot, great, whey protein benefits, and cream prices are poor it’s offsetting . If cheese demand globally is growing or fat demand’s growing, great we’ll maneuver our recipe a bit to take advantage of that. It feels very… Optimized maybe is not the right word. Someone help me with a word for it. But it feels like it’s a natural hedge, and it just seems if we’re gonna continue to grow in the commodity foundation of dairy products and then optimize all the ingredients and all the special opportunities around it, the cheese processing facility is maybe going to be the best to build around. And so with that in mind, I don’t know if that necessarily takes a greater market share, but it’s gonna be the foundation for our growing volume of milk solids out of the U.S. over the next several years. Ted Jacoby III: Josh it’s funny, you mentioned, are we gonna start balancing into cheese versus balancing into a powder plant? And my initial reaction when you first mentioned it a year or so ago was to say, “A cheese plant is just way too expensive.” It’s two, three times the cost to build a cheese plant as it is to build a plant that [00:22:00] dries non-fat. But the more I thought about it, the more I started to realize this: Already today we’ve seen a fundamental shift, and it will continue. I think cheese will always get enough milk to run the plant, but the competition for that marginal next pound of milk that could go to any of those plants, I think the competition for that last pound of milk has been ratcheted up a notch or two, and I don’t think cheese is gonna win that battle at all costs, like it historically has. And so I think there are times when your UF milk plants, when your ESL plants, and even when your non-fat butter plants are gonna win that competition from time to time. And so, the balancing function for a milk supply is gonna start getting spread over the course of multiple plants rather than the way we’ve been over the last 50 years, where everything was balanced in and out of a milk drying plant. All right. So have we decided? Have we come to a conclusion? Is cheese king? Let’s just go around. Is cheese gonna stay king? Mike, is cheese gonna stay king? Mike Brown: Cheese will stay king, but the strength of its kingdom will be a little weaker, ’cause it’s gonna have some strong competition from other proteins. Ted Jacoby III: Perfect. Jake? Jacob Menge: Couldn’t have said it better. Agree completely. Yep. Ted Jacoby III: Gus? Gus Jacoby: I would agree with how Mike said it. Yeah. Ted Jacoby III: Awesome. Joe? Joe Maixner: Yeah. No, no argument here. Ted Jacoby III: Diego? Diego Carvallo: I’ll have to say no. It’s because of the high competition and the amount of plants that are being built right now. Joe Maixner: Yeah. Ted Jacoby III: So are you saying you agree or disagree? Diego Carvallo: I disagree. Mike Brown: It’s the degree that cheese is ahead; it’s gonna take a lot of time for that to shift. Ted Jacoby III: A little bit like the Roman Empire in the year 200 AD, it’s still got 250 years to go, but it’s no longer gonna be the powerhouse it was 50 years previous. Josh, what do you think? Josh White: Yeah cheese is the king, and we’re gonna build a bigger kingdom around it. Ted Jacoby III: All right. And I agree with the general consensus that the cheese stays king, but the trend of an ever-increasing percentage of the supply is starting to slow down a bit. All right, everybody. Hey, this was a great [00:24:00] conversation. Thanks for joining us today. To all of our very valued listeners, we thank you for taking the time to listen to us. And if anybody ever has any questions about some of the topics we talk about, don’t ever be afraid to reach out and contact T.C. Jacoby & Company. We’re always happy to help. Take care, everybody.

Explore the dynamics of the gold market, supply constraints, technological innovations, gold as a currency, and technology in mining efficiency, with Agnico Eagle Mines CEO Ammar Al-Joundi. 00:00 Introduction 03:30 Drivers of Gold Prices 14:38 Challenges to Gold's Bullish Outlook 17:24 Supply Constraints in Gold Mining 21:33 Advantages of Operating in Developed Markets 25:56 Investor Perspectives on Gold Mining 32:38 Leveraging Technology for Efficiency 42:05 Trend or Fad?

Is high protein just another fad diet?Learn about the 3 criteria that define a fad, how protein performs against each one, the research on lean mass and strength training, the mechanisms behind protein's thermic effect and satiety, and why the case gets stronger for adults over 40.This episode covers the fad diet framework, research updates on protein and muscle building, the thermic effect on your metabolism and the satiety research that gives protein an advantage over carbs and fat, findings on muscle protein synthesis, and thedata on lean mass and body composition when postmenopausal women lose fat.Plus the protein leverage mechanism behind menopausal weight gain and a 3-question test for evaluating any nutrition trend you see on social media or TikTok.Get the Protein Day Builder, the tool that maps out a full day of meals hitting your protein target based on your schedule, dietary preferences, and the foods you eat every week.Don't forget: the Fitness Lab app is 20% off through Friday, May 8. AI-powered nutrition and training coaching for adults over 40: witsandweights.com/appTimestamps0:00 - High protein fad narrative 3:25 - What defines a fad diet 4:30 - Fad diet examples 5:45 - The (false) link with fat and carb demonization 6:40 - High protein vs. the fad criteria 8:15 - Meta-analyses on protein and lean mass 9:45 - Sustainability and physical activity 11:45 - Hitting your protein target in practice 13:15 - Thermic effect of protein 15:40 - Protein and satiety 17:10 - Muscle protein synthesis and meal distribution 19:45 - Muscle loss and strength after 40 20:45 - Menopause and protein leverage 22:30 - Adequate protein for your goals 24:10 - 3-question fad diet testEpisode ResourcesJoin Eat More Lift Heavy, the 26-week coached program that includes the Protein Day Builder as one of many helpful tools to better plan your meals, build muscle, and lose fat sustainably

Explore the biggest tax planning changes of 2026, the One Big Beautiful Act, Roth conversion pitfalls, and how AI is reshaping wealth management, with Wealth.com Senior Tax Strategist Shane Ball. 00:00 Introduction 08:28 The Role of Technology in Tax Planning 17:08 Common Tax Mistakes and Best Practices 17:56 Navigating State and Federal Tax Provisions 18:28 Understanding Roth Conversions 25:09 Integrating Estate and Tax Planning 27:17 The Future of Tax Policy 31:46 Investment Trends and Insights 34:24 Trend or Fad?

I Studied Nutrition and Still Made a Mess of Eating Snag your free Nutrition Self Check and Eat to Energize Menu!  What happens when a dietitian can't figure out her own body? In this episode, Jess gets honest about her personal journey with food — the parts that worked, the parts that didn't, and the discovery that changed everything. Jess traces her story from 90s fad diets and college bulimia, through a spiritual awakening abroad that helped her separate her identity from her appearance, to a decade of intuitive eating that served her well — until the demands of motherhood pushed her body past its limits. Years of fatigue, insomnia, and gut issues followed, and a perimenopause diagnosis finally prompted her to stop and ask a bigger question. The answer wasn't what she expected. Her nervous system had been running in sympathetic overdrive for years, quietly driving nearly every symptom she was experiencing. Learning to balance her sympathetic and parasympathetic nervous systems — and to value rest as much as activity — became the turning point. In this episode Jess also shares the three core beliefs that anchor her practice: The body is designed to be healthy when properly supported Most nutrition information is true, but not all of it is helpful for every person Food is deeply personal — and your nutrition plan should be too This is the story behind the Empowered Eating model, and an invitation to start your own journey. Topics covered: Fad diet culture and its impact Eating disorder recovery without formal treatment Intuitive eating — and its limits Nervous system health and digestion Perimenopause and listening to your body The Empowered Eating framework   Snag your free Nutrition Self Check and Eat to Energize Menu!  Learn more about working with Jess at jessbrownrd.com

Fred and Blake start things off with the Show Open, Joseph Hoyt joins the show to talk all things Dallas Cowboys, and Fred and Blake make their picks for the Cowboys. A look at the NBA Playoffs, Mike Babot joins the show to talk all things Texas Rangers, and a Fair or Foul. The Stars gear up for the NHL Playoffs, Blake goes off, and Trevor Beck has Good News! FAD talks about the nerdiest things to do in High School, TOLOs call in for Faddies on the Fones, and Show Close.

FAD talks about the nerdiest things to do in High School, TOLOs call in for Faddies on the Fones, and Show Close.

Ready to break through your Keto or low carb plateau? Book your free consultation call with Robert Sikes here: https://www.ketobodybuilding.com/callYou are sabotaging your own health goals without even realizing it. Your shallow breathing and high stress levels are destroying your digestion, blocking fat burning, and leading to hormone imbalances. The key to improving your health isn't just about what you eat, but how your body functions from the inside out.In episode 867 of the Savage Perspective Podcast, host Robert Sikes sits down with Dr. John Douillard to reveal how ancient Ayurvedic wisdom holds the answers to modern health problems like metabolic syndrome and fatigue. They explore how simple changes in your breathing can improve your lymphatic system, reset your digestion, and create lasting energy. This episode provides the tools you need to stop fighting your body and finally work with it to achieve your best state of health.Follow Dr. John Douillard on IG: https://www.instagram.com/lifespa/Get Keto Brick: https://www.ketobrick.com/Subscribe to the podcast: https://open.spotify.com/show/42cjJssghqD01bdWBxRYEg?si=1XYKmPXmR4eKw2O9gGCEuQChapters0:00 - The Optimal Intermittent Fasting Window For Fat Loss0:58 - How an Ironman Triathlon Led to A Surprising Discovery3:16 - The "Eye of the Storm" Secret for Peak Performance5:22 - How Nasal Breathing Scientifically Unlocks The "Runner's High"6:29 - Why Life Feels Like a Struggle (And How to Fix It)8:23 - The Unexpected Habit That Boosts Athletic Power10:29 - The Science of "Calm Amidst Chaos" for Elite Performance12:36 - What Is Ayurveda? A Beginner's Guide13:19 - How Seasonal Eating Optimizes Your Gut Microbiome15:34 - The Forgotten System Key to Longevity16:30 - Is Brain Fog Linked to a Congested Brain?18:13 - Why Most Athletes Have a Weak Diaphragm (And Don't Know It)20:51 - Are Food Intolerances a Myth? The Real Cause23:15 - Is 1g of Protein Per Pound of Bodyweight a Fad?25:07 - The Single Biggest Lever to Pull for Better Digestion27:13 - How to Properly Practice Breathwork for Maximum Benefit28:03 - Are You "Over-Breathing"? The Signs of Oxygen Inefficiency29:07 - The Perfect Storm for Anxiety (And How to Reverse It)30:00 - A Message From Robert Sikes31:40 - How Your Mental State Affects Nutrient Absorption32:21 - What is Metabolic Syndrome and What Truly Causes It?35:12 - The Real Reason for PMS Symptoms (It's Not Hormones)37:14 - What Is The Optimal Meal Frequency for Digestion?38:45 - The Truth About Intermittent Fasting: Breakfast vs. Supper43:03 - One Meal a Day (OMAD): Pros and Cons46:16 - TRT & HRT: Are They a First Line of Defense?50:00 - How to Test The Health of Your Lymphatic System at Home50:35 - How to Preserve Your Nitric Oxide Production52:41 - The Ancient Ayurvedic Tool for Oral Health55:20 - Dr. Douillard's Daily Morning Routine for Longevity59:31 - Dr. Douillard's Evening Wind-Down Routine1:02:15 - Where to Find Dr. John Douillard

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About the Guest Dr. Dustin Oedekoven is the chief veterinarian for the National Pork Board, based in Des Moines, Iowa. In this role, Dr. Oedekoven leads a team of veterinarians and swine production experts in Pork Checkoff-funded work for pork producers, including foreign animal disease (FAD) preparedness, protecting the U.S. herd from African swine fever and developing a national swine health strategy. Dr. Oedekoven has over 20 years of experience in the agriculture sector. Prior to joining the National Pork Board in 2022, he served as state veterinarian and executive secretary for the South Dakota Animal Industry Board, where he provided strategic leadership and direction for the state's animal health agency – a seven-member, governor-appointed board of livestock producers with responsibility for all animal health programs and disease control efforts in the state. Dr. Oedekoven received his Doctor of Veterinary Medicine degree from Iowa State University and bachelor’s degree in Agricultural Science from South Dakota State University. He resides in Pierre, South Dakota, with his wife and kids. What can you expect to learn from this episode of Popular Pig? Why the National Swine Health Strategy was created and how pig health directly impacts producer profitability. The two big goals guiding the strategy: reduce the impact of domestic diseases and keep foreign and emerging diseases out. Why PRRS elimination is now being set as a long term industry destination. Why PED elimination may be more achievable in the near term and how recent progress gives the industry momentum.

Explore how fintech and AI expand access to personalized financial guidance, regardless of wealth level, and why human connection is vital in the age of AI with Connective CEO Ian Rosen. 00:00 Introduction 02:49 The Gaps in Financial Education and Advisory Services 09:08 Building Trust in Financial Services 13:03 Addressing Financial Anxiety and Health 14:37 The Journey to Founding Connective 23:08 The Future of Human Connection in Wealth Management 31:36 The Ripple Effect of Financial Support 32:31 The Need for Financial Professionals 42:24 Trend or Fad?

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What Kind of Business Should I Buy? If you're thinking about buying a business, this is the question that determines everything. Not how to fund it. Not how to structure it. Not even how to find it. But what kind of business should you buy? In this week's episode, Jonathan Jay answers the foundational question every serious dealmaker must get right and explains why choosing the wrong business is the fastest way to sabotage your future success  . Start With the End in Mind Jonathan opens with a principle borrowed from Stephen Covey: Begin with the end in mind. Before you even look at sectors or valuations, you need clarity on your outcome. Are you: Escaping corporate life? Growing your existing business? Building a group to sell for seven or eight figures? Each goal demands a completely different acquisition strategy. If you want to replace your salary, Jonathan challenges you to aim higher than feels comfortable. If you want to scale your current company, acquisition is the fastest way to move the needle. If you want generational wealth, buy-and-build might be your path. But the type of business you buy must match the outcome you want. Why Most First-Time Buyers Aim Too Low One of the most controversial sections of this episode? Size. Jonathan argues that most first-time buyers go too small — and pay the price. Businesses making under £100,000 net profit often: Depend too heavily on the owner Lack proper management accounts Have fragile teams Leave no room for post-acquisition wobble Instead, he shares what he looks for: At least £1m revenue At least £200k net profit Stable margins (15–25%+) Strong management in place Recurring or repeat revenue The effort required to buy a £200k profit business is not ten times harder than buying a £20k one. But the impact on your life absolutely is. The Three Core Acquisition Paths Jonathan breaks down three common strategies: Escape the Day Job: Buy a business that produces serious income — ideally 10x your salary. Grow an Existing Business: Acquire competitors, suppliers, complementary businesses, or geographic expansions. Buy-and-Build: Acquire smaller businesses at lower multiples, combine them, and sell the larger group at a higher multiple. He explains: What fragmented markets are Why M&A activity above you matters How multiple arbitrage works Why strong management becomes critical at scale And importantly — why one deal can change your life. The Worst Types of Businesses to Buy Jonathan doesn't hold back here. Avoid: Owner-dependent businesses Fad businesses Highly volatile or "spiky" profit businesses Overleveraged acquisitions Companies reliant on family members Businesses where relationships walk out the door with the seller He also explains why buying too small can mean buying yourself a job. And that's not what this is about. Funding, Risk and Structure This episode also covers: Why over-leveraging kills deals Why working capital matters more than most buyers realise Why your first deal is the most important Why corporate structure must be set up properly Why personal guarantees should be limited and contained Jonathan's position is clear: Deal number one sets the foundation for everything that follows. Get it right, and you build momentum. Get it wrong, and you may never do deal two. The Big Takeaway Buying a business isn't just about buying something. It's about buying the right thing. With: The right margins The right management The right structure The right funding And the right strategic fit for your long-term goal Clarity at the beginning prevents regret later. Listen Now If you're serious about buying a business in 2026 — or even just thinking about it — this episode gives you the strategic filter you need before you start looking at opportunities. Listen now and make sure your first deal is the right one.   If you're serious about buying a business – and avoiding the mistakes Jonathan outlines – book a free Clarity Call with one of his team:

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In this episode, I sit down with Daria Mochly-Rosen to explore the powerful role mitochondria play in our energy, brain health, metabolism, and long term resilience. We talk about the science behind sleep, strength training, stress, and nutrition, and how simple daily habits can support better healthspan without falling into burnout or extreme biohacks.We also cover the cultural pressure to hustle nonstop, why slowing down is not a weakness, and how connection, family, and meaningful conversations can actually support your biology. She breaks down the fascinating truth about how we inherit mitochondria, how lifestyle choices influence cellular health, and why it is never too late to start building stronger, more resilient energy from the inside out.→ Leave Us A Voice Message! Topics Discussed:→ What are mitochondria?→ How to boost energy?→ Does sleep affect health?→ Best habits for longevity?→ Are mitochondria inherited?Sponsored By: → Function | Own your health for $365 a year. That's a dollar a day. Learn more and join using my link. Visit https://www.functionhealth.com/bewellbykelly and use gift code BEWELL25 for a $25 credit toward your membership→ Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com.→ Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/KELLY and save up to 39% off your Mitopure® Gummies.→ Fatty 15 | Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. You can get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/KELLY15 and using code KELLY15 at checkout.Timestamps: → 00:00:00 - Introduction→ 00:01:57 - What are mitochondria?→ 00:02:48 - Mitochondria in each cell→ 00:03:46 - Krebs cycle, ATP + metabolism→ 00:06:24 - Cellular energy production→ 00:08:22 - Nutrition for energy→ 00:14:08 - Healthy vs refined carbs→ 00:17:05 - Sugar + metabolic health→ 00:19:12 - Fad diets explained→ 00:23:45 - Lifestyle changes for longevity→ 00:30:33 - Stress + mitochondrial health→ 00:35:59 - Mitophagy + autophagy benefits→ 00:40:46 - Glymphatic brain detox→ 00:43:09 - Exercise + movement science→ 00:49:10 - Mitochondrial peptides→ 00:55:16 - MOTS-C peptide benefits→ 00:56:35 - Chronic disease + mitochondria→ 01:02:38 - Reactive oxygen species→ 01:07:36 - Family, connection + health→ 01:12:07 - Fertility + energy health→ 01:15:01 - Building healthy mitochondriaFurther Listening: → The Key to Longevity: Exploring Mitochondrial Uncoupling with Dr. Steven GundryCheck Out Daria:→ Stanford | https://med.stanford.edu/profiles/daria-mochly-rosen→ Linkedin | https://www.linkedin.com/in/daria-mochly-rosen-9733bb198→ Book |

Fad workouts have been with us for decades, but they go back much further than we realize. Long before CrossFit, Zumba, P90X, Tae Box, Jazzercise or Jack LaLanne, we had 19th century strongmen. These mustachioed showmen were the first global fitness influencers. They hauled trunks of weights onto steamships, toured the world, then sold exercise equipment through the mail. The most famous was Eugene Sandow, who broke chains, and created with his own body a "manned cavalry bridge" where he would lie down while men, horses, and a carriage were driven over his body. He even fought a lion in front of an auditorium and won, although the lion was almost definitely sedated. Today’s guest is Connor Heffernan, author of “When Fitness Went Global: The Rise of Physical Culture in the Nineteenth Century.” In this episode, we discuss: Ancient Egyptians were basically doing CrossFit thousands of years ago. They trained with swinging sandbags that look exactly like modern kettlebell flows. One of the first exercise practices to experience globalization was Indian club-swinging. Indian club-swinging, originating from the heavy training clubs used by Indian wrestlers and soldiers for centuries, was observed and adopted by British military officers stationed in India during the early 1800s. Early diet culture was a carnival of quack science. Victorian fitness magazines were filled with miracle tonics, starvation cures and pseudoscientific meal plans. Many of our “new” diet trends are rebranded versions of schemes first marketed with sepia portraits and dubious testimonials. See omnystudio.com/listener for privacy information.

Explore today's ETF landscape, including retail usage, AI in portfolios, market outlook, regulations, and the rise of active ETFs with President and Director of Research at ETF.com, Dave Nadig. 00:00 Introduction 02:27 ETF Awards and Innovations 04:41 State of the ETF Landscape 12:01 Regulatory Changes and ETF Launches 17:59 Active ETFs and Market Trends 32:04 Navigating the Challenges of Private Investments 38:05 Emerging Trends in Investment Products 40:23 The Impact of AI on Investment Strategies 53:18 Trend or Fad?

FAD gets started with the Show Open, Benjamin Allbright joins the show to talk all things NFL, Mavs After Dark, and Jeanie Buss.

FAD gets started with the Show Open, Benjamin Allbright joins the show to talk all things NFL, Mavs After Dark, and Jeanie Buss. Tom Hale joins the show to talk about the upcoming winter storm, a fan favorite Fair or Foul, and the latest on Rich Paul and Anthony Davis. A look around the entire NFL with NFL Stack, are the Cowboys any closer to finding a DC, and Jacob Regh has Jaking Off. Show reset, Phone lines open for Faddies on the Fones, and Show Close.

In this powerful episode of Coaching In Session, Michael Rearden sits down with Allyson Hurley, a Certified Personal Trainer and Nutrition Coach, for a transformative conversation about nutrition, wellness, mindset and behavior change. If you've ever struggled with diet confusion, unrealistic fitness expectations, or the pressure of society's body standards, this episode delivers clarity and direction.Allyson breaks down common myths about diets, explains why carbs are not the enemy, and reveals how behavior-based goals can lead to lasting health results. Michael and Allyson dive deep into the connection between nutrition, mindset, and emotional wellbeing—highlighting how food affects not just the body, but also confidence, stress, and mental clarity.This episode is packed with practical insights about sustainable habits, trial-and-error learning, building a positive relationship with food, and setting goals rooted in self-awareness. If you're ready to simplify nutrition, improve your mindset, and create a healthier relationship with food, this conversation will guide you every step of the way.What You'll Learn in This Episode-Nutrition doesn't need to be complicated, simple approaches work-Why carbs have been misunderstood and how they support a balanced diet-The truth about fad diets and why they fail long-term-How understanding your body leads to better weight management-Why behavior-based goals outperform weight-only goals-How mindset influences fitness, motivation and consistency-The role of trial and error in discovering what works for you-How unrealistic expectations damage motivation-Why support, encouragement and accountability matter-How to create long-term balance with food without restrictionKey Takeaways✅ Nutrition can be simple and effective when personalized✅ Carbs are not inherently bad; balance is key✅ Understanding your body improves weight management✅ Fad diets are often unsustainable and ineffective✅ Behavior-based goals lead to lasting results✅ Mindset strongly influences nutrition and fitness success✅ Trial and error is essential for discovering what works✅ Realistic expectations maintain motivation✅ Support and encouragement improve adherence and results✅ Long-term balance is critical for sustainable health

Learn about the importance of behavioral finance in understanding investor emotions, decision-making, and common behavioral mistakes investors make with Chief Behavioral Officer, at RFG Advisory, Brendan Frazier. 00:00 Introduction 03:29 Journey into Behavioral Finance 12:21 Behavioral Mistakes Investors Make 14:17 The Impact of Past Experiences on Financial Behavior 22:43 The Rivalry Between Current and Future Sel 25:15 Understanding Client Goals and Motivations 30:50 The SAFE Framework for Clients 38:11 Setting Expectations to Mitigate Fear 42:39 The Impact of Technology on Human Behavior 44:56 Trend or Fad?

Join host Joe Baya as he kicks off the first Northwest Florida Fishing Report of 2026, featuring expert insights from top guides Brandon Barton (Pensacola) and Captain Justin Leake (Panama City). This episode covers essential winter fishing tips for inshore and offshore anglers, from targeting bull redfish around bridges and flats, to safety considerations for kayak fishermen during colder months.  Learn the most effective live and artificial bait strategies for snapper, grouper, flounder, and scamp, and discover how changing weather patterns, tides, and wind conditions influence local fishing success. The discussion also spotlights the region's growing artificial reef and FAD projects, fishery management best practices, and the ongoing transition towards sustainable fishing in Northwest Florida. Whether you fish Pensacola, Panama City, or anywhere along the Emerald Coast, this report offers actionable advice and high-impact techniques to help you make the most of winter fishing in Florida's top angling destinations.   Sponsors: Dixie Supply and Baker Metal Killerdock Coastal Connection EXP Realty AFTCO Sea Tow SlipSki Solutions Black Buffalo Saltwater Marketing Stayput Anchor

In this episode, Rory Mitchell sits down with Kayla Girgen for an in-depth conversation on health, fitness, nutrition, and rucking one of the most effective and underrated forms of functional training. Together, they break down how rucking workouts improve mental toughness, strength, endurance, and overall wellness, making it an accessible fitness method for beginners and experienced athletes alike. The discussion explores the physical and mental benefits of rucking, why setting realistic fitness goals leads to long-term success, and how to approach nutrition without restriction. Kayla shares expert insight on fad diets, metabolic health, continuous glucose monitoring, and why flexible dieting and cheat meals can play a healthy role in sustainable weight loss and performance. Rory and Kayla also tackle the realities of content creation in the health and fitness industry, discussing why authentic fitness content, meaningful engagement, and real education matter more than follower counts or viral trends.This episode highlights the importance of building trust, community, and credibility in the wellness space. To close out the conversation, Kayla introduces her new book, RuckFit, a practical guide to rucking for fitness, fat loss, and longevity, and explains how rucking has evolved into a powerful community-driven fitness movement that brings people together through shared challenge and accountability. Whether you're looking for a beginner rucking guide, smarter approaches to nutrition and metabolic health, or motivation to stay consistent with your fitness goals, this episode delivers actionable advice, mindset shifts, and real-world strategies you can apply immediately.Takeaways Rucking is a simple yet effective way to improve fitness.Mental health benefits are as important as physical health.Focus on building sustainable habits rather than just setting goals.Flexibility in diet allows for better long-term adherence.Cheat meals can be beneficial if managed properly.Fad diets often lead to unsustainable results.Continuous glucose monitoring can help manage diet effectively.Community and social connections enhance the rucking experience.Content creation requires consistency and authenticity.Engagement with a smaller audience can be more impactful than sheer numbers.Contact Kayla Girgen  INSTAGRAM: https://www.instagram.com/kaylagirgenrd/Pre-Order The Book: https://a.co/d/j7X2YX7YouTube: https://www.youtube.com/@kaylagirgenrdTikTok: https://www.tiktok.com/@kaylagirgenrdFacebook: https://www.facebook.com/kaylagirgenrdldLinkedIn: https://www.linkedin.com/in/kaylagirgen/

Send us a textOrder a copy of my debut film, Cape Cod Cthulhu!Happy New Year!The first podcast of 2026 is filled with all of the GenX nostalgia and pop culture you could want!Episode 226 kicks off with a look at 1990s fitness fad fails. Common New Year's Resolutions revolve around health, fitness, and weight loss. We will look at some products, diets, and exercise equipment that were marketed to those looking to achieve a healthier life. Unfortunately, not all of them were successes; some were downright dangerous. A new year means a new look back 30 years into the world of music. This week, we look at 1996, the year in music, focusing on January through June. News, songs, albums, and general thoughts about the music scene are here in this segment. The first Top 5 of 2026 goes back to the first golden age of television commercials. We look at the most fondly remembered product advertising mascots of the 1960s. Many of these still exist to this day. How many do you remember?There is a new This Week In History and Time Capsule looking back to the creation of FM radio.Happy New Year to all of my listeners!You can support my work by becoming a member on Patreon. Or you can Buy Me A Coffee!Helpful Links from this EpisodeBuy My New Book, In Their Footsteps!Searching For the Lady of the Dunes True Crime BookHooked By Kiwi - Etsy.comDJ Williams MusicKeeKee's Cape Cod KitchenChristopher Setterlund.comCape Cod Living - Zazzle StoreSubscribe on YouTube!Initial Impressions 2.0 BlogCJSetterlundPhotos on EtsyListen to Episode 225 hereSupport the show

Hear how understanding individual money stories and shared contributions helps couples build a healthier relationship with each other through money, with Money Together authors Douglas and Heather Boneparth. 00:00 Introduction 02:06 The Book Launch and Reception 10:59 The Impact of Personal Experiences on Financial Views 21:05 Navigating Difficult Conversations About Money 31:39 The Importance of Financial Knowledge 32:11 Joint vs. Separate Accounts 34:26 Navigating Financial Agency 36:23 Addressing Non-Financial Risks 39:43 Planning for Future Caregiving 42:01 The Impact of Technology on Relationships 44:30 Trend or Fad?

Hour 1

From investing through the modern data stack era (DBT, Fivetran, and the analytics explosion) to now investing at the frontier of AI infrastructure and applications at Amplify Partners, Sarah Catanzaro has spent years at the intersection of data, compute, and intelligence—watching categories emerge, merge, and occasionally disappoint. We caught up with Sarah live at NeurIPS 2025 to dig into the state of AI startups heading into 2026: why $100M+ seed rounds with no near-term roadmap are now the norm (and why that terrifies her), what the DBT-Fivetran merger really signals about the modern data stack (spoiler: it's not dead, just ready for IPO), how frontier labs are using DBT and Fivetran to manage training data and agent analytics at scale, why data catalogs failed as standalone products but might succeed as metadata services for agents, the consumerization of AI and why personalization (memory, continual learning, K-factor) is the 2026 unlock for retention and growth, why she thinks RL environments are a fad and real-world logs beat synthetic clones every time, and her thesis for the most exciting AI startups: companies that marry hard research problems (RAG, rule-following, continual learning) with killer applications that were simply impossible before.We discuss:* The DBT-Fivetran merger: not the death of the modern data stack, but a path to IPO scale (targeting $600M+ combined revenue) and a signal that both companies were already winning their categories* How frontier labs use data infrastructure: DBT and Fivetran for training data curation, agent analytics, and managing increasingly complex interactions—plus the rise of transactional databases (RocksDB) and efficient data loading (Vortex) for GPU-bound workloads* Why data catalogs failed: built for humans when they should have been built for machines, focused on discoverability when the real opportunity was governance, and ultimately subsumed as features inside Snowflake, DBT, and Fivetran* The $100M+ seed phenomenon: raising massive rounds at billion-dollar valuations with no 6-month roadmap, seven-day decision windows, and founders optimizing for signal (”we're a unicorn”) over partnership or dilution discipline* Why world models are overhyped but underspecified: three competing definitions, unclear generalization across use cases (video games ≠ robotics ≠ autonomous driving), and a research problem masquerading as a product category* The 2026 theme: consumerization of AI via personalization—memory management, continual learning, and solving retention/churn by making products learn skills, preferences, and adapt as the world changes (not just storing facts in cursor rules)* Why RL environments are a fad: labs are paying 7–8 figures for synthetic clones when real-world logs, traces, and user activity (à la Cursor) are richer, cheaper, and more generalizable* Sarah's investment thesis: research-driven applications that solve hard technical problems (RAG for Harvey, rule-following for Sierra, continual learning for the next killer app) and unlock experiences that were impossible before* Infrastructure bets: memory, continual learning, stateful inference, and the systems challenges of loading/unloading personalized weights at scale* Why K-factor and growth fundamentals matter again: AI felt magical in 2023–2024, but as the magic fades, retention and virality are back—and most AI founders have never heard of K-factor—Sarah Catanzaro* X: https://x.com/sarahcat21* Amplify Partners: https://amplifypartners.com/Where to find Latent Space* X: https://x.com/latentspacepodFull Video EpisodeTimestamps00:00:00 Introduction: Sarah Catanzaro's Journey from Data to AI00:01:02 The DBT-Fivetran Merger: Not the End of the Modern Data Stack00:05:26 Data Catalogs and What Went Wrong00:08:16 Data Infrastructure at AI Labs: Surprising Insights00:10:13 The Crazy Funding Environment of 2024-202500:17:18 World Models: Hype, Confusion, and Market Potential00:18:59 Memory Management and Continual Learning: The Next Frontier00:23:27 Agent Environments: Just a Fad?00:25:48 The Perfect AI Startup: Research Meets Application00:28:02 Closing Thoughts and Where to Find Sarah Get full access to Latent.Space at www.latent.space/subscribe

From investing through the modern data stack era (DBT, Fivetran, and the analytics explosion) to now investing at the frontier of AI infrastructure and applications at Amplify Partners, Sarah Catanzaro has spent years at the intersection of data, compute, and intelligence—watching categories emerge, merge, and occasionally disappoint. We caught up with Sarah live at NeurIPS 2025 to dig into the state of AI startups heading into 2026: why $100M+ seed rounds with no near-term roadmap are now the norm (and why that terrifies her), what the DBT-Fivetran merger really signals about the modern data stack (spoiler: it's not dead, just ready for IPO), how frontier labs are using DBT and Fivetran to manage training data and agent analytics at scale, why data catalogs failed as standalone products but might succeed as metadata services for agents, the consumerization of AI and why personalization (memory, continual learning, K-factor) is the 2026 unlock for retention and growth, why she thinks RL environments are a fad and real-world logs beat synthetic clones every time, and her thesis for the most exciting AI startups: companies that marry hard research problems (RAG, rule-following, continual learning) with killer applications that were simply impossible before. We discuss: The DBT-Fivetran merger: not the death of the modern data stack, but a path to IPO scale (targeting $600M+ combined revenue) and a signal that both companies were already winning their categories How frontier labs use data infrastructure: DBT and Fivetran for training data curation, agent analytics, and managing increasingly complex interactions—plus the rise of transactional databases (RocksDB) and efficient data loading (Vortex) for GPU-bound workloads Why data catalogs failed: built for humans when they should have been built for machines, focused on discoverability when the real opportunity was governance, and ultimately subsumed as features inside Snowflake, DBT, and Fivetran The $100M+ seed phenomenon: raising massive rounds at billion-dollar valuations with no 6-month roadmap, seven-day decision windows, and founders optimizing for signal ("we're a unicorn") over partnership or dilution discipline Why world models are overhyped but underspecified: three competing definitions, unclear generalization across use cases (video games ≠ robotics ≠ autonomous driving), and a research problem masquerading as a product category The 2026 theme: consumerization of AI via personalization—memory management, continual learning, and solving retention/churn by making products learn skills, preferences, and adapt as the world changes (not just storing facts in cursor rules) Why RL environments are a fad: labs are paying 7–8 figures for synthetic clones when real-world logs, traces, and user activity (à la Cursor) are richer, cheaper, and more generalizable Sarah's investment thesis: research-driven applications that solve hard technical problems (RAG for Harvey, rule-following for Sierra, continual learning for the next killer app) and unlock experiences that were impossible before Infrastructure bets: memory, continual learning, stateful inference, and the systems challenges of loading/unloading personalized weights at scale Why K-factor and growth fundamentals matter again: AI felt magical in 2023–2024, but as the magic fades, retention and virality are back—and most AI founders have never heard of K-factor — Sarah Catanzaro X: https://x.com/sarahcat21 Amplify Partners: https://amplifypartners.com/ Where to find Latent Space X: https://x.com/latentspacepod Substack: https://www.latent.space/ Chapters 00:00:00 Introduction: Sarah Catanzaro's Journey from Data to AI 00:01:02 The DBT-Fivetran Merger: Not the End of the Modern Data Stack 00:05:26 Data Catalogs and What Went Wrong 00:08:16 Data Infrastructure at AI Labs: Surprising Insights 00:10:13 The Crazy Funding Environment of 2024-2025 00:17:18 World Models: Hype, Confusion, and Market Potential 00:18:59 Memory Management and Continual Learning: The Next Frontier 00:23:27 Agent Environments: Just a Fad? 00:25:48 The Perfect AI Startup: Research Meets Application 00:28:02 Closing Thoughts and Where to Find Sarah

FAD goes all around the NFL with NFL Stack, Brennan Baxter joins the show talking all things College Football, and Fair or Foul.

Fred and Blake kick things off with the Show Open, Reactions to Jerry Jones Audio, and Brett Siegel joins the show. FAD goes all around the NFL with NFL Stack, Brennan Baxter joins the show talking all things College Football, and Fair or Foul. A look around the entire NFL, Carter Freemon and Jake Riepma join the show talking all things college football and the CFP, and the NFL Pro Bowl players have been announced. Another edition of Extra Credit, the phone lines open for Faddies on the Fones, and show close.

The boys, back in town, discuss what they have beenlistening to. Their list includes four rock-n-roll hall of famers, three recently departed legends, two underground rap heavyweights, and a partrige in a pear tree. Jay's wing gets clipped as Deon's sampling gets a little out of hand. Get into it.Sonic contributors to the 28th BONUS episode of Lightnin' Licks Radio podcast include: A wealth of treasures from the KPM Archives; the prompt was 50's lounge. Brothers Johnson, Dave Matthews Band, DJ NuMark, Jurassic 5. James Todd Smith, Ice Cube, One Eye, Cynthia Fee & Andrew Gold, Sleepy Donnie POSPOTUS, Darling Jula @soundwavesoffwax, MattHeller A.K.A. DJ Snakes. The E-Street Band. Bruce Springsteen, The Boss-type beats, Bob Dylan, Timothy Chalamet, Paul Walter Houser, Jeremy Allen White. Bon Iver, Cowboy Junkies, Pavement. Stephen Malkmus, Lottie's, Talking Heads, R.E.M., Warren Zevon, John Hammond. Miranda from Endless Scroll podcast, Dua Lipa, Tame Impala, The Beatles, Lil' Yachty, Marvin Gaye, J.J. Fad, Black Circle Radio, Arc of All, The Source of Light and Power, Open Mike Eagle's What Had Happened Was podcast, Chris Rock, Height Keech, Prince Paul. Handsome Boy Modeling School, Dr. Octogon, Kool Keith, Dan the Automater, Chris Elliot, Right Said Fred, Beastie Boys, Bee Gees, Kardinall Offshall, Sly Boogy, TikTokker @cgleason22, Dave James, D'Angelo, Questlove, Questlove's eulogy of D'Angelo, Prince, The Roots, Dr. Dre & Snoop Doggy Dogg, The Vanguard, DJ Premier, Q Tip, Brian Baumgartner, Blindboy Boatclub, Iggy Pop, Kiss, Ace Frehly, Dick Dale, Phill Most Chill, RUN DMC, Soft Cell, Pet Shop Boys, Human League, Jimi Hendrix, Sammy Cahn, Jimmy Van Heusen, Frank Sinatra, Bobby Darin, and actor Larry Thomas. Our super-secret-special-sonic friends that we may or may not have even ever met include Miranda Reinert, Mitch Anderson, Open Mike Eagle, and Prince Paul.Suggestions: Deon – Cowboy Junkies by way of BruceSpringsteen, Lottie's, D'Angelo, and Phill Most Chill. Jay – New old R.E.M., Warren Zevon, Ace Frehly, Soft Cell. Miranda – Tame Impala. Mitch – Sweetwater, but not the 90's grunge outfit, rather the 60's psych folk collective. Mike & Paul – Doctor Octogon by way of Handsome Boy Modeling School.Mixtape can be heard UNCUT on Soundcloud HERE. A Spotifyplaylist with most featured tracks can be found HERE. As expected, the mix is cut fom the episode due to copyright claims. Please purchase music. Also like and subscribe to cool podcasts. Also volunteer in your community. (1) Sweetwater - In a Rainbow (2) Phill Most Chill - I'm (3) Warren Zevon - The Worrier King (4) Ace Frehley - What's on Your Mind? (5) Lottie's - The Cut.(1) Cowboy Junkies - My Father's House (2) D'Angelo and the Vanguard - Another Life (3) Tame Impala and HAIM - 'Cause I'm a Man [Deon's Half&Half remix] (4) R.E.M. - Radio Free Europe [Jacknife Lee remix] (5) Dr. Octagon - BlueFlowers [Prince Paul's It's so Beautiful remix] (6) Soft Cell -Where the Heart is.Happy Holidays.

Welcome to the last Q&A session of 2025. In this show we cover selling properties to invest in pensions instead, starting to invest for the first time, UFPLS vs FAD and SO MUCH MORE! Shownotes: https://meaningfulmoney.tv/QA36  02:05  Question 1 Big thanks to Pete and Roger for all the excellent advice. This question is for some of the 2.8 million UK landlords. Even those with just one property in their own name—not through a limited company—are increasingly affected by fiscal drag. Looking ahead, I plan to sell down much of my property portfolio in later life (because who wants to be a landlord at 70?). Plus, mortgage finance becomes trickier in your 70s. That said, even if I retain one or two of the best properties, the rental income alone may push me into the higher-rate tax bracket. I'm 49 and don't currently have a SIPP, but I can invest up to the £60k annual allowance via my limited company. Would it make sense to start building a modest pension over the next 10 years as a risk mitigation strategy? If so, how should I think about the opportunity cost? I'd save 25% corporation tax going in, but pay higher-rate income tax on the way out (less the 25% tax-free lump sum)—so is the net tax cost around 5%? Or am I overlooking other factors, like the benefit of CGT and income tax exemptions on growth within the pension? Appreciate your thoughts—and keep up the great work. Regards, Cameron. 07:29  Question 2 Hi Pete, Roger and Nick, I've recently discovered your YouTube channel and podcast, and it's been a real eye-opener - thanks so much for all the great content! I'm 45 and currently have £74,000 in a Fidelity SIPP, but it's all sitting in cash. I know that's far from ideal, especially with 15–20 years until I plan to retire. I also realise it's a relatively modest pot for my age, and it's not earning anything while it just sits there. How would you typically advise someone in my situation to begin investing some or all of that cash? I'm keen to make up for lost time but want to do so wisely. Thanks again, and keep up the brilliant work! Joanne 15:15  Question 3 Hi Pete & Roger, Firstly thanks so much for all your hard work - I devour your podcasts, videos & books - so much hard work on your behalf & I hope you realise how appreciated they are. I am just at the stage of life where in the next few years I need to start thinking about drawing money out of mine & my husband's pensions and I am considering the most tax efficient way of doing this. I have been reading all about UFPLS and FAD. As background, it is unlikely that either my husband or I will ever have much Personal Allowance unused in the years up to receiving our State Pensions due to rental income we receive; it is also unlikely that either of us will ever become higher rate taxpayers. I also understand that to get the most out of ones PCLS it is best to only crystallise the funds actually needed from an uncrystallised pension so the rest of the pot can hopefully grow and therefore the 25% tax free sum also grows.  So, my question is, what am I missing, in what situations would it be more beneficial to take an UFPLS payment v making a partial crystallisation into a FAD pot (I am with ii who offer this). I feel like an UFPLS payment would give me 25% tax free and 75% taxed right away, whilst a FAD would give me the same 25% tax free and 75% could be taken straight away or drawn down over time as desired and could also be left invested to hopefully grow? Thanks so much, Tracy 21:12  Question 4 Hi Pete and Roger, thanks for hosting such a great podcast! I've recently been searching for a new job and was lucky enough to receive an offer with some interesting compensation features that I thought I would ask your opinions on. I actually turned down this role in favour of something else, but wanted to ask nonetheless as the offer came with an interesting feature that I have not come across before. Firstly, and probably most straightforward to answer – The salary on offer was £50,500 per year, which seems a weird figure – suspiciously only slightly above the threshold to tip me into the higher tax bracket, which got me thinking – are there any benefits (to the employer or employee) of being only just into the next tax bracket up? Why not £50k, or £51k? Secondly, in addition to a very generous DC pension scheme (they would pay in 12% if I pay in 5%) they offer a "Savings Scheme" whereby 5% of my salary would be deducted (and paid into this scheme) each month and at the end of 12 months the company would then top up these savings with another 5% of my annual salary – (actually 6% to "account for the extra tax"). My real question is this – what are these "savings schemes" in a nutshell, and are there any benefits of them over trying to negotiate for increased employer pension contributions instead? Interested to hear your thoughts on these. Thanks so much! Jamie 29:09  Question 5 Hello Pete and Roger I've recently found your podcast and wanted to say thanks for all the insight you are providing. Not only do you make a fairly dull subject tolerable, you even manage to make it reasonably enjoyable

FAD 8:40 segment

FAD 10:20 segment

The boys, back in town, discuss what they have been listening to. Their list includes four rock and roll hall of famers, three recently departed legends, two underground rap heavyweights, and a partridge in a pear tree. Jay's wing gets clipped as Deon's sampling gets a little out of hand. Get into it.Sonic contributors to the 28th BONUS episode of Lightnin' Licks Radio podcast include: A wealth of treasures from the KPM Archives; the prompt was "50's lounge." Dave Matthews Band, DJ Nu Mark, Jurassic 5, Brothers Johnson. Zach Braff & Natilie Portman. Ice Cube, One Eye. Sleepy Don POSPOTUS, Darling Jula from @soundwavesoffwax. E Street Band. Bruce Springsteen, The Boss-type beats, Bob Dylan, Timothy Chalamet, Paul Walter Houser, Jeremy Allen White, Bon Iver, Cowboy Junkies, Matt "DJ SNAKES" Heller, Pavement. Stephen Malkmus, Lottie's, Talking Heads, R.E.M., Warren Zevon, John Hammond, Endless Scroll podcast, Dua Lipa, Tame Impala, The Beatles, Lil' Yachty, Marvin Gaye, J.J. Fad. Black Circle Radio, Arc of All, The Source of Light and Power, Open Mike Eagle's 'What Had Happened Was' podcast, Chris Rock, Height Keech, Paul Edward Huston, Handsome Boy Modeling School, Dr. Octagon, Dan the Automater, Chris Elliot, Right Said Fred, Beastie Boys, Bee Gees, Kardinall Offshall, Sly Boogy, TikTokker @cgleason22, Dave James, D'Angelo, Questlove, Questlove's recent eulogy of D'Angelo, Prince, The Roots, Dr. Dre & Snoop Doggy Dogg. The Vanguard, DJ Premier, Q Tip. Brian Baumgartner, Blindboy Boatclub, Iggy Pop. Kiss, Ace Frehley, Dick Dale, Phill Most Chill, RUN DMC, Soft Cell, Pet Shop Boys, Human League, Jimi Hendrix, Frank Sinatra, Jimmy Van Heusen & Sammy Cahn, Bobby Darin. And lastly, but certainly not leastly, the lovely sisters HAIM. Our super-secret-special-sonic friends whom we may or may not have even ever met include Miranda Reinert, Mitch Anderson, Open Mike Eagle, and Prince P-p-p-paul.Sonic suggestions, what we have been funkiing with: Deon – Cowboy Junkies by way of Bruce Springsteen, Lottie's, D'Angelo, and Phill Most ChIll. Jay – New old R.E.M., Warren Zevon, Ace Frehley, and Soft Cell. Miranda – Tame Impala (w HAIM).Mitch – Sweetwater, not the 90's grunge act but the 60's psychedelic folk oufit.Mike and Paul – Doctor Octagon by way of Handsome Boy Modeling School.HEAR the full uncut mixtape HERE.(1) Sweetwater - In a Rainbow (2) Phill Most Chill - I'm (3) Warren Zevon - The Worrier King (4) Ace Frehley - What's on Your Mind? (5) Lottie's - The Cut.(1) Cowboy Junkies - My Father's House [outtake] (2) D'Angelo and the Vanguard - Another Life (3) Tame Impala and HAIM - 'Cause I'm a Man [Deon's Half&Half remix] (4) R.E.M. - Radio Free Europe [Jacknife Lee remix] (5) Dr. Octagon - Blue Flowers [Prince Paul's It's so Beautiful remix] (6) Soft Cell -Where the Heart is,MERRY CHRISTMAS and HAPPY HOLIDAYS!

HR 5 - Joseph Hoyt, Sounds of the Sports Day, Cross Talk with FAD full 2534 Thu, 11 Dec 2025 01:55:49 +0000 Eg7pwDU5H48rVIP57s9yiU1k2xN9u7Ke sports GBag Nation sports HR 5 - Joseph Hoyt, Sounds of the Sports Day, Cross Talk with FAD The G-Bag Nation - Weekdays 10am-3pm 2024 © 2021 Audacy, Inc. Sports False https://player.amperwavepod

On today's episode we are joined by KFC and Big T for a draft of the best parts of 2009. The Categories are: Movie, Song, Sports, Story, and Fad.You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/thedogwalk