Podcasts about ipi

If you could save your loved one from their serious illness, you would do that. Of course you would.You love them and you want the best for them, whether they're battling cancer, Alzheimer's disease, ALS, age-related decline, or another advanced illness. You want to be the best caregiver you can be, and I'll bet you're exhausted.Yet you may be spending your precious energy trying to fix the unfixable, rather than focusing on being wholeheartedly present with your loved one.This episode of The Integrative Palliative Podcast tackles how to show up as the best caregiver you can be and how to figure out what is yours to take on and what is not.I'm glad you're here.Dr. Deliawww.doctordelia.comCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com  Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Persuasion seems conspicuously absent from our politics.  Not shouting, denouncing, or trying to convince the "other side" that they're wrong, evil, or both.  But the good faithed attempt to reach the hearts, minds, and emotions of others and persuade them to our point of view.  Why?  Why is persuasion so hard?  And is it even possible to persuade in an era of political polarization?   Saving Elephants host Josh Lewis welcomes fellow "Josh"—Josh Bandoch—on the show to discuss his latest book, How to Get What You Want: Mastering the Art and Science of Persuasion, and to explore how persuasion can engage with how the human brain is actually wired.   About Josh Bandoch Bio from Illinois Policy   Josh Bandoch is the Head of Policy at the Illinois Policy Institute.   His research focuses on empowering people to rise out of poverty, increasing social mobility, improving housing affordability, and removing barriers to opportunity (e.g. burdensome regulations). His work has appeared in popular outlets like National Review, Real Clear Policy, RealClearMarkets, Chicago Tribune, Chicago Sun-Times, Crain's Chicago Business, The Washington Examiner, The Washington Times, and Discourse, as well as peer-reviewed journals like Political Studies. He regularly appears in the media to discuss these and other policy issues, and speaks regularly at local and national events.   He is the author of The Politics of Place: Montesquieu, Particularism, and the Pursuit of Liberty (University of Rochester Press, 2017), which has received numerous positive reviews. He's currently working with his literary agent to submit his book manuscript on persuasion to publishers. He's using his persuasion research to develop strategies to advocate for policies that expand freedom and prosperity.   Josh is a member of the American Enterprise Institute's Leadership Network – a policy education and professional development program for state-based leaders in public, private, and nonprofit sectors. Before joining IPI, Josh was a Research Fellow at the Competitive Enterprise Institute, a speechwriter for numerous senior government officials, a strategic communications consultant at Booz Allen Hamilton, and a postdoctoral fellow at Brown University and the University of Wisconsin-Madison.   He earned his bachelor's in Government and Politics from the University of Maryland, College Park, and his Ph.D. in Political Science from the University of Notre Dame.   To learn more about Josh, check out his website joshuabandoch.com  

Senado pode retomar isenção de IPI para organizações sem fins lucrativos e Mara Gabrilli cobra explicações do TSE sobre campanha de representatividade sem pessoas com deficiência. 

The newly released emails and internal communications detailed by Fortune paint a picture of Jeffrey Epstein using the prestige of the International Peace Institute and its connections to the United Nations and the Gates Foundation to expand both his influence and his personal network long after his 2008 conviction. According to the report, Epstein allegedly helped facilitate nearly $1 million in donations from Leon Black to IPI, while simultaneously leveraging relationships within the organization to secure jobs, introductions, and visa recommendation letters for several young women connected to him. Emails released by the DOJ reportedly show Epstein embedding himself into philanthropic and diplomatic circles despite already being a registered sex offender, using respected institutions as a shield for reputation laundering and access.The report also highlights how Epstein allegedly cultivated close ties with IPI leadership, particularly former president Terje Rød-Larsen, while presenting himself as a high-level connector capable of bringing in wealthy donors and elite contacts. Women who later spoke publicly described being drawn into Epstein's orbit through promises of education, careers, travel opportunities, and professional advancement tied to these institutions. The article argues that Epstein weaponized the credibility of globally recognized nonprofits and philanthropic networks to maintain social legitimacy and control over vulnerable women, even as public knowledge of his criminal history continued to grow.to contact me:bobbycapucci@protonmail.comsource:How Jeffrey Epstein leveraged a U.N.-affiliated nonprofit—and the Gates Foundation—to control women | Fortune

The newly released emails and internal communications detailed by Fortune paint a picture of Jeffrey Epstein using the prestige of the International Peace Institute and its connections to the United Nations and the Gates Foundation to expand both his influence and his personal network long after his 2008 conviction. According to the report, Epstein allegedly helped facilitate nearly $1 million in donations from Leon Black to IPI, while simultaneously leveraging relationships within the organization to secure jobs, introductions, and visa recommendation letters for several young women connected to him. Emails released by the DOJ reportedly show Epstein embedding himself into philanthropic and diplomatic circles despite already being a registered sex offender, using respected institutions as a shield for reputation laundering and access.The report also highlights how Epstein allegedly cultivated close ties with IPI leadership, particularly former president Terje Rød-Larsen, while presenting himself as a high-level connector capable of bringing in wealthy donors and elite contacts. Women who later spoke publicly described being drawn into Epstein's orbit through promises of education, careers, travel opportunities, and professional advancement tied to these institutions. The article argues that Epstein weaponized the credibility of globally recognized nonprofits and philanthropic networks to maintain social legitimacy and control over vulnerable women, even as public knowledge of his criminal history continued to grow.to contact me:bobbycapucci@protonmail.comsource:How Jeffrey Epstein leveraged a U.N.-affiliated nonprofit—and the Gates Foundation—to control women | Fortune

The newly released emails and internal communications detailed by Fortune paint a picture of Jeffrey Epstein using the prestige of the International Peace Institute and its connections to the United Nations and the Gates Foundation to expand both his influence and his personal network long after his 2008 conviction. According to the report, Epstein allegedly helped facilitate nearly $1 million in donations from Leon Black to IPI, while simultaneously leveraging relationships within the organization to secure jobs, introductions, and visa recommendation letters for several young women connected to him. Emails released by the DOJ reportedly show Epstein embedding himself into philanthropic and diplomatic circles despite already being a registered sex offender, using respected institutions as a shield for reputation laundering and access.The report also highlights how Epstein allegedly cultivated close ties with IPI leadership, particularly former president Terje Rød-Larsen, while presenting himself as a high-level connector capable of bringing in wealthy donors and elite contacts. Women who later spoke publicly described being drawn into Epstein's orbit through promises of education, careers, travel opportunities, and professional advancement tied to these institutions. The article argues that Epstein weaponized the credibility of globally recognized nonprofits and philanthropic networks to maintain social legitimacy and control over vulnerable women, even as public knowledge of his criminal history continued to grow.to contact me:bobbycapucci@protonmail.comsource:How Jeffrey Epstein leveraged a U.N.-affiliated nonprofit—and the Gates Foundation—to control women | FortuneBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-moscow-murders-and-more--5852883/support.

The newly released emails and internal communications detailed by Fortune paint a picture of Jeffrey Epstein using the prestige of the International Peace Institute and its connections to the United Nations and the Gates Foundation to expand both his influence and his personal network long after his 2008 conviction. According to the report, Epstein allegedly helped facilitate nearly $1 million in donations from Leon Black to IPI, while simultaneously leveraging relationships within the organization to secure jobs, introductions, and visa recommendation letters for several young women connected to him. Emails released by the DOJ reportedly show Epstein embedding himself into philanthropic and diplomatic circles despite already being a registered sex offender, using respected institutions as a shield for reputation laundering and access.The report also highlights how Epstein allegedly cultivated close ties with IPI leadership, particularly former president Terje Rød-Larsen, while presenting himself as a high-level connector capable of bringing in wealthy donors and elite contacts. Women who later spoke publicly described being drawn into Epstein's orbit through promises of education, careers, travel opportunities, and professional advancement tied to these institutions. The article argues that Epstein weaponized the credibility of globally recognized nonprofits and philanthropic networks to maintain social legitimacy and control over vulnerable women, even as public knowledge of his criminal history continued to grow.to contact me:bobbycapucci@protonmail.comsource:How Jeffrey Epstein leveraged a U.N.-affiliated nonprofit—and the Gates Foundation—to control women | FortuneBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-moscow-murders-and-more--5852883/support.

The newly released emails and internal communications detailed by Fortune paint a picture of Jeffrey Epstein using the prestige of the International Peace Institute and its connections to the United Nations and the Gates Foundation to expand both his influence and his personal network long after his 2008 conviction. According to the report, Epstein allegedly helped facilitate nearly $1 million in donations from Leon Black to IPI, while simultaneously leveraging relationships within the organization to secure jobs, introductions, and visa recommendation letters for several young women connected to him. Emails released by the DOJ reportedly show Epstein embedding himself into philanthropic and diplomatic circles despite already being a registered sex offender, using respected institutions as a shield for reputation laundering and access.The report also highlights how Epstein allegedly cultivated close ties with IPI leadership, particularly former president Terje Rød-Larsen, while presenting himself as a high-level connector capable of bringing in wealthy donors and elite contacts. Women who later spoke publicly described being drawn into Epstein's orbit through promises of education, careers, travel opportunities, and professional advancement tied to these institutions. The article argues that Epstein weaponized the credibility of globally recognized nonprofits and philanthropic networks to maintain social legitimacy and control over vulnerable women, even as public knowledge of his criminal history continued to grow.to contact me:bobbycapucci@protonmail.comsource:How Jeffrey Epstein leveraged a U.N.-affiliated nonprofit—and the Gates Foundation—to control women | FortuneBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

The newly released emails and internal communications detailed by Fortune paint a picture of Jeffrey Epstein using the prestige of the International Peace Institute and its connections to the United Nations and the Gates Foundation to expand both his influence and his personal network long after his 2008 conviction. According to the report, Epstein allegedly helped facilitate nearly $1 million in donations from Leon Black to IPI, while simultaneously leveraging relationships within the organization to secure jobs, introductions, and visa recommendation letters for several young women connected to him. Emails released by the DOJ reportedly show Epstein embedding himself into philanthropic and diplomatic circles despite already being a registered sex offender, using respected institutions as a shield for reputation laundering and access.The report also highlights how Epstein allegedly cultivated close ties with IPI leadership, particularly former president Terje Rød-Larsen, while presenting himself as a high-level connector capable of bringing in wealthy donors and elite contacts. Women who later spoke publicly described being drawn into Epstein's orbit through promises of education, careers, travel opportunities, and professional advancement tied to these institutions. The article argues that Epstein weaponized the credibility of globally recognized nonprofits and philanthropic networks to maintain social legitimacy and control over vulnerable women, even as public knowledge of his criminal history continued to grow.to contact me:bobbycapucci@protonmail.comsource:How Jeffrey Epstein leveraged a U.N.-affiliated nonprofit—and the Gates Foundation—to control women | FortuneBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

Jeffrey Epstein cultivated relationships with influential figures from around the world, including political, academic, and diplomatic circles in Scandinavia. One of the most scrutinized connections was his association with Terje Rød-Larsen, the Norwegian diplomat best known for helping broker the Oslo Accords between Israel and the Palestinians. Epstein donated hundreds of thousands of dollars to the International Peace Institute (IPI), where Rød-Larsen served as president, and internal financial reviews later revealed that Epstein had also provided personal loans and financial assistance directly to Rød-Larsen himself. The relationship drew intense scrutiny after Epstein's 2019 arrest, especially because the payments and ties were not publicly disclosed at the time. Critics questioned why a high-profile international diplomat and peace negotiator maintained any association with Epstein after Epstein's 2008 conviction for soliciting sex from a minor, particularly given Epstein's increasingly toxic public reputation and the growing awareness of allegations surrounding him.The fallout eventually forced Rød-Larsen to resign from the IPI in 2020 after an internal investigation determined that he had failed to fully disclose the financial relationship with Epstein to the organization. Reports indicated that Epstein had maintained access to elite diplomatic and policy circles through figures like Rød-Larsen, reinforcing broader concerns about how Epstein embedded himself among influential global networks long after his criminal conduct had become public knowledge. The relationship also fueled criticism that many powerful institutions and international figures were willing to overlook Epstein's background so long as he continued providing money, connections, or prestige. While there has never been any public allegation that Rød-Larsen was involved in Epstein's criminal conduct, the controversy surrounding their relationship became another example of how Epstein used philanthropy, elite networking, and financial entanglements to remain connected to influential people across Europe and the United States even after his conviction.to contact me:bobbycapucci@protonmail.com

Jeffrey Epstein cultivated relationships with influential figures from around the world, including political, academic, and diplomatic circles in Scandinavia. One of the most scrutinized connections was his association with Terje Rød-Larsen, the Norwegian diplomat best known for helping broker the Oslo Accords between Israel and the Palestinians. Epstein donated hundreds of thousands of dollars to the International Peace Institute (IPI), where Rød-Larsen served as president, and internal financial reviews later revealed that Epstein had also provided personal loans and financial assistance directly to Rød-Larsen himself. The relationship drew intense scrutiny after Epstein's 2019 arrest, especially because the payments and ties were not publicly disclosed at the time. Critics questioned why a high-profile international diplomat and peace negotiator maintained any association with Epstein after Epstein's 2008 conviction for soliciting sex from a minor, particularly given Epstein's increasingly toxic public reputation and the growing awareness of allegations surrounding him.The fallout eventually forced Rød-Larsen to resign from the IPI in 2020 after an internal investigation determined that he had failed to fully disclose the financial relationship with Epstein to the organization. Reports indicated that Epstein had maintained access to elite diplomatic and policy circles through figures like Rød-Larsen, reinforcing broader concerns about how Epstein embedded himself among influential global networks long after his criminal conduct had become public knowledge. The relationship also fueled criticism that many powerful institutions and international figures were willing to overlook Epstein's background so long as he continued providing money, connections, or prestige. While there has never been any public allegation that Rød-Larsen was involved in Epstein's criminal conduct, the controversy surrounding their relationship became another example of how Epstein used philanthropy, elite networking, and financial entanglements to remain connected to influential people across Europe and the United States even after his conviction.to contact me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

Palliative care chaplain Daniel Deloma shares the powerful modality that he uses with seriously ill, hospice and end of life patients - Meditative Heartbeat Therapy.It helps reduce pain, anxiety, and fear and has powerful impacts on patient, family and caregiver wellbeing.It is a technique that family members can use to help their own stress, help their grieving, and support their loved one.Learn more and contact chaplain DeLoma at www.heartbeatherapy.comI'm glad you're here,Dr. Deliahttps://DoctorDelia.comCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com  Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Conocé cómo se comportaron los diferentes sectores que conforman el IPI manufacturero en el segundo mes del año. 

O governo federal vai aumentar o IPI e o preço mínimo do cigarro para compensar o PIS/Confins do querosene de aviação, que será zerado.

When a loved one has a serious illness like cancer or dementia, or they have age-related decline, it can seem like your life has turned upside-down. Nobody prepares you for this.Sometimes the skills that are helpful in regular life actually make caregiving harder. But you can repurpose those skills to make caregiving easier.This episode of The Integrative Palliative Podcast will show you why hyper-competent people can struggle when a loved one is ill - and what to do about it.- Doctor Deliawww.DoctorDelia.comFree Guide: Nobody Prepares You for Thishttps://trainings.integrativepalliative.com/pl/2148761984 Coping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com  Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Are psychedelics the new wonder drugs for mental health? One could be excused for thinking so given the buzz in the field, the impressive research results, the rush of patients and practitioners lining up for a piece of the promise. But it's a young field. And like any goldrush, full of pitfalls, misleading claims and confusion.  In order to shed some clarity on this emerging field, psychiatrist Dr. William van Deveer and psychologist, Dr. Keith Kurlander, co-founders of The Integrative Psychiatry Institute (IPI), have just come out with their first book Psychedelic Therapy: Restore Your Mental Health, Reclaim Your Life, which aims to be a grounded guidebook for those wanting to learn more about the research and practice of working with psychedelics.  I had the pleasure of interviewing Dr. van Deveer for the MindHealth360 Show, where we discuss his unique approach to integrating functional medicine and psychedelic therapy to address the deeper drivers of mental ill health, be they biochemical or psychospiritual. Drawing on his own journey out of conventional psychiatry, he describes how the limits of talk therapy and medication led him to explore the gut–brain connection, somatic trauma therapy and psychedelic-assisted treatment – and why an understanding of root causes across body, mind and spirit are essential to long-term healing. Through the IPI, Dr. van Deveer and Dr. Kurlander have trained thousands of clinicians in integrative approaches to mental health and more than 2,500 in psychedelic-assisted psychotherapy. Dr. van Deveer has also staffed MAPS-sponsored clinical trials in MDMA-assisted psychotherapy. In this conversation, he shares how his work has evolved from conventional psychiatry into a broader model that integrates functional medicine, trauma-informed care and psychedelic therapy. In this practical and wide-ranging discussion, Dr. van Deveer outlines his framework for assessing mental health through a broad map of root causes – including lifestyle, detoxification, infections, the microbiome, autoimmunity, psychology and spirituality. He explains why many patients need both functional medicine and psychedelic therapy, especially as early trauma, insecure attachment and physiological dysregulation are often intertwined. He also explores the distinct biochemical profiles of MDMA, ketamine and psilocybin, and shows why psychedelic treatment is most effective when it is used not as a standalone fix, but as a catalyst for deeper healing, behaviour change and self-care. Dr. van Deever, alongside co-author Dr. Keith Kurlander, will release Psychedelic Therapy: A Revolutionary Approach to Restoring Your Mental Health and Reclaiming Your Life on May 31. In this episode, you'll learn: What led Dr. van Derveer to move beyond conventional psychiatry after discovering how limited medication and talk therapy could be for many patients. How a former patient's recovery from panic disorder and agoraphobia after being diagnosed with celiac disease transformed his understanding of the gut–brain connection and led him to explore the wider biological root causes of mental illness. Why he sees functional medicine and psychedelic therapy as two complementary healing traditions that often need to be used together. How his treatment model maps root causes across lifestyle, the body, detoxification, infections, the microbiome, autoimmunity, psychology and spirituality. Why early trauma may be stored outside narrative memory – in somatic, episodic and procedural memory – and continue to shape beliefs, relationships and health behaviours. How insecure attachment and early dysregulation can underlie self-beliefs and behaviour patterns that later contribute to addiction, inflammation and poor health. Why Dr. van Derveer believes inflammation is a common pathway linking trauma, gut dysfunction and other drivers of mental illness. How MDMA, ketamine and psilocybin differ in their biochemical effects, psychological impact and spiritual potential. Why he describes MDMA as pro-inflammatory in the short term, ketamine as potentially helpful in reducing the impact of quinolinate-related excitotoxicity, and psilocybin as having broader anti-inflammatory effects. Why psychedelic therapy works best as a catalyst for self-love, spirituality, and sustained lifestyle change within ongoing therapeutic work—not as a one-off, "pill for an ill" intervention detached from root causes.

In this episode of JCO Article Insights, host Dr.  Ash Gurumurthi summarizes JCO articles, "Phased Variant–Supported Circulating Tumor DNA as a Prognostic Biomarker After First-Line Treatment in Large B-Cell Lymphoma: Findings From the DIRECT Study" and " Prospective Validation of Circulating Tumor DNA Measurable Residual Disease After First-Line Therapy in Large B-Cell Lymphoma" TRANSCRIPT Ash Gurumurthi: Hi and welcome to JCO Article Insights. I'm your host, Ash Gurumurthi, and today we will be discussing two articles, both published in the Journal of Clinical Oncology, on the real-world utility of circulating tumor DNA (ctDNA) MRD in newly diagnosed large B-cell lymphoma. The first study is the article "Phased-Variant-Supported Circulating Tumor DNA as a Prognostic Biomarker After First-Line Treatment in Large B-Cell Lymphoma: Findings From the DIRECT Study" by Dr. Joanna Krupka and colleagues in the United Kingdom. For the sake of convenience, I'll refer to this as the DIRECT study. The second study is "The Prospective Validation of Circulating Tumor DNA Measurable Residual Disease After First-Line Therapy in Large B-Cell Lymphoma" by Dr. Steven Wang and colleagues in the Netherlands, referred to as the HOVON 902 study. By way of background, I wanted to talk about MRD in hematolymphoid malignancies. Nodal diseases have lacked a robust biomarker for end-of-treatment response. They have relied historically on PET scans interpreted using the semiquantitative Deauville 5-point scale, which has a high negative predictive value but a limited positive predictive value. The poor positive predictive value for survival results in extended follow-up with serial imaging for risk stratification with unnecessary and invasive biopsies. There have been recent revolutionary advancements in ctDNA MRD in B-cell lymphoma. The use of ctDNA in lymphoma began with CAPP-seq, which tracked single nucleotide variants that were tumor specific but was limited by excessive background sequencing noise with false negatives. To overcome this, Dr. Kurtz and colleagues developed the proprietary PhasED-seq assay. This tracks well-recognized phased mutations on the same DNA strand in cis configuration within hypermutated regions that are unique to B-cell lymphoma. Using this method, they pushed their limit of detection at 95%, the so-called LOD95, to 0.7 parts per million under optimal circumstances with 120 nanograms of input cell-free DNA from plasma. Based on the use of the PhasED-seq assay in trials of newly diagnosed large B-cell lymphoma with the use of investigational agents, the NCCN currently recommends consideration of ctDNA MRD assay with a detection limit of less than 1 part per million if biopsy is not feasible for a positive end-of-treatment PET. However, I believe this threshold needs reconsideration given it is based on an ideal assay LOD95 under optimal circumstances rather than sample-specific LOD95. Real-world validation of the role of end-of-treatment ctDNA and appropriate thresholds for sample-specific LOD95 were lacking until the publication of these two studies. The DIRECT and the HOVON 902 studies were multicenter, prospective trials using real-world cohorts of newly diagnosed large B-cell lymphoma treated with standard anthracycline immunochemotherapy, ie, R-CHOP chemotherapy. They validated end-of-treatment ctDNA MRD response measured on a phased-variant platform and found them to be strongly prognostic for relapse and survival. This was independent of PET imaging or baseline clinical prognostication like the International Prognostication Index, the IPI. They also demonstrated a threshold with an LOD95 of approximately 1 in 100,000 is necessary for clinical utility. Both trials recruited over a similar period between 2020 to 2023, with the DIRECT study conducted within the National Health Service in the United Kingdom and the HOVON 902 as a national study in the Netherlands. For survival analysis, only patients who reached the landmark event of end of treatment with an available ctDNA MRD sample without progressive disease or death at that time point were included. These studies evaluated similar-sized cohorts with 134 patients for HOVON 902 and 151 patients for the DIRECT study. As expected, their baseline demographics are reflective of a real-world population of newly diagnosed cases with large B-cell lymphoma. Although both used comparable statistical methodologies with time-to-event analysis, the primary outcomes vary, making headline comparisons quite challenging. The DIRECT study utilized the time to tumor progression, censoring death unrelated to disease. This was done to isolate the molecular impact of detectable ctDNA at the end of treatment. In contrast, the HOVON 902 study used progression-free survival, which counts all-cause mortality as an event. This naturally results in lower event-free rates for PFS compared to TTP in the DIRECT study. The trials differed in their choice of phased-variant platforms, with the DIRECT study developing an independent, fully open-source phased-variant ctDNA assay. This has been released on GitHub. In contrast, the HOVON 902 study utilized PhasED-seq by Foresight Diagnostics, which is currently the only proprietary and commercially available phased-variant assay for lymphoid malignancies. Interestingly, despite the differences in platforms and the primary end points, the results were remarkably consistent. The DIRECT study found a highly significant difference in the 2-year TTP rate of 96% in those with undetectable ctDNA MRD at the end of treatment compared to 45% in those with detectable ctDNA, with a hazard ratio of 15. Similarly, the HOVON 902 study found a significantly superior 3-year PFS of 85% in those with undetectable ctDNA compared to 17% with detectable ctDNA, with a hazard ratio of 10. Crucially, both studies found end-of-treatment ctDNA MRD significantly outperformed PET response assessment for long-term PFS. In fact, for the end point of PFS in both trials, the baseline IPI lost all statistical significance in both univariate and multivariable analysis when accounting for ctDNA MRD and PET status at the end of treatment. While both studies demonstrate the superiority of ctDNA MRD compared to PET in predicting survival, interestingly, the combination of both tests appeared to be complementary in identifying the highest-risk group. The HOVON 902 study identified 13 patients who were double positive, ie, they were positive with end-of-treatment PET and detectable ctDNA MRD. Every single one of these patients progressed over a 3-year period with a dismal overall survival of 17%. The DIRECT study mirrored these findings with the same double-positive group having a 2-year time to progression rate of 23%. Given consistency in identifying the poor outcome of this double-positive population in both studies, this is clearly a group that would benefit from trial-based approaches like consolidation or, alternatively, frequent surveillance for clinical relapse. On the other hand, the best-performing group was the double negative, ie, those who had achieved PET negative and ctDNA undetectable at the end of treatment. The double-negative group had a 2-year time to progression of 97% in the DIRECT study and a 3-year PFS of 88% in the HOVON 902 trial. This is quite impressive. Based on these findings, we can anticipate that ctDNA may complement rather than wholly replace PET at the end of treatment for response assessment. Perhaps the most critical finding from both studies challenged current NCCN-recommended ctDNA MRD sensitivity threshold of achieving less than one part per million. While phased-variant assays can theoretically detect this, this is under optimal conditions, specifically 120 nanograms of input cell-free DNA. In both trials, only 3% of samples could achieve this sensitivity, with the vast majority limited to a sample-specific LOD95 of approximately 1 in 100,000 informative reads. The primary constraint was simply limited plasma volume collected, a denominator problem of input cell-free DNA. For example, the HOVON 902 study had a median plasma volume of 5 mL, yielding 20 nanograms of input DNA. The DIRECT study elegantly demonstrated bridging the gap to attain the NCCN standard of LOD95 of less than 1 part per million is practically impossible. This would require greater input DNA, attained through a 20- to 30-milliliter collection of plasma rather than the standard 10 milliliters, and a massive 20- to 40-fold increase in sequencing depth. With the current real-world sensitivity of roughly 1 in 100,000 in both these studies, the negative predictive value is already nearly at 90%. There is going to be diminishing returns for further analytical sensitivity. This strongly suggests that the NCCN guidelines should be updated to prioritize achievable sample-specific LOD95 rather than assay-specific theoretical limits. Collectively, these studies validate the real-world utility of ctDNA MRD as an independent predictor of long-term outcomes following first-line therapy of large B-cell lymphoma. Finally, after two decades of the default R-CHOP for all, the field of aggressive large B-cell lymphoma is taking leaps and bounds by integrating ctDNA MRD with the current wave of bispecific and cellular therapies. I want to now leave you with my five key clinical takeaways from both these studies. ●        Firstly, ctDNA MRD is a more potent independent predictor of outcome than end-of-treatment PET/CT and baseline IPI. ●        Second, ctDNA MRD in first-line large B-cell lymphoma is already reshaping clinical trial space with therapeutic escalation and de-escalation strategies based on ctDNA kinetics during treatment, as well as identifying candidates with persistent ctDNA at the end of treatment for consolidation approaches. ●        Thirdly, this technology is ready for prime time. Whether this is through Foresight's PhasED-seq assays or the open-source method released by the DIRECT group, academic centers can now operationalize this in routine clinical care. ●        Fourth, biology clearly provides a ceiling. Current sensitivity goals of less than one part per million as recommended by the NCCN are limited by the actual amount of cell-free DNA we can extract from a patient's blood, not just the assay's technology. I believe these two studies will inform the NCCN's next revision to move away from theoretical assay limits to a more realistic sample-specific LOD95 of approximately 1 in 100,000. ●        Finally, it appears that the end-of-treatment ctDNA MRD test may be complementary to PET/CT rather than a replacement. Clearly, the best outcomes are seen in double-negative patients, while double-positive results, ie, positive end-of-treatment PET and detectable ctDNA at the end of treatment, identify a group with an extremely high risk of early progression who may need early intervention. Thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries, and be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

Friday, March 20, 2026 Welcome to our Weekend Edition with host Kerby Anderson. His co-hosts are IPI's Dr. Merrill “Buddy” Matthews and from First Liberty Institute, Chief Legal Officer Jeff Mateer. Topics for discussion are religious freedom, politics influence on education, our families, and Kerby will share his experiences on their tour of Greece and […]

Já está no ar o novo episódio do podcast STJ No Seu Dia, que repercute uma recente decisão da Primeira Turma do Superior Tribunal de Justiça (STJ) sobre a concessão da isenção do IPI na compra de veículos destinados à atividade de táxi, mesmo para profissionais que ainda não estão em exercício, desde que possuam autorização ou permissão prévia do poder público.Em conversa com o jornalista Thiago Gomide, a advogada tributarista Ellen Licar repercute os fundamentos do julgamento relatado pelo ministro Paulo Sérgio Domingues, que destacou o caráter extrafiscal da isenção e afastou a interpretação que exigia o exercício prévio da profissão como condição para o benefício.O episódio explica como o tribunal reforçou que a finalidade da Lei 8.989/1995 é facilitar o acesso ao instrumento de trabalho e ampliar as oportunidades para novos taxistas, evitando restrições não previstas pelo legislador. A decisão também evidencia a importância de interpretar as isenções de forma coerente com sua função social, garantindo que o benefício alcance tanto os profissionais já estabelecidos quanto aqueles que buscam ingressar na atividade.STJ No Seu Dia       Com entrevistas em linguagem acessível sobre questões institucionais ou jurisprudenciais do Tribunal da Cidadania, o podcast é veiculado às sextas-feiras, às 21h30, na Rádio Justiça (104,7 FM – Brasília), e também está disponível no canal do STJ no Spotify e em outras plataformas de áudio.

Caregivers put so much energy into caregiving yet they still struggle with self-criticism and feeling like their best isn't good enough.Every caregiver deserves self-forgiveness.Listen this week to find out the five areas that can lead caregivers to carry shame, and what they can do about it.Your wellbeing matters.Doctor Deliawww.DoctorDelia.comCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

¿Querés saber cómo cuál fue la evolución de los distintos grupos de especies al inicio del año? Conocé más en el informe del IPI pesquero del INDEC.

It is hard to be a doctor and it is hard to be a patient (or a family member of a patient). Everyone in the healthcare system is frustrated.Both patients and doctors are doing their best, but sometimes it doesn't feel that way. Doctors are busy and burned out which can make patients and families feel blown off or disrespected.The week on The Integrative Palliative Podcast you'll get an insider's view of how to get the best from your doctor.www.DoctorDelia.comCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Jeffrey Epstein's entanglement with Leon Black and Larry Summers runs through the Jeffrey Epstein VI Foundation and its flagship project, the Institute for New Economic Thinking (INET), born out of the wreckage of the 2008 financial crisis. Black, the billionaire Apollo founder, bankrolled INET with roughly $25 million and installed himself as its chief patron, while Summers — fresh off his controversial presidency at Harvard and a career bouncing between Wall Street and Washington — became one of its intellectual faces. Epstein, already a convicted sex offender by 2008, quietly emerged as a financial conduit and behind-the-scenes broker for INET and its affiliates, using donor networks, shell foundations, and elite access to move money and cultivate influence. Through Epstein's foundation, funds were routed into academic projects, conferences, and research hubs that placed him back inside elite academic circles that had supposedly shut him out, laundering his reputation through economics, philanthropy, and intellectual respectability.What makes the IPI/INET web so corrosive is how thoroughly it fused money, power, and reputational cover. Black would later admit paying Epstein $158 million for “tax advice,” an explanation so implausible it collapsed under its own weight, while Summers maintained institutional ties to projects and donors connected to Epstein long after his 2008 conviction was public record. Epstein was not a peripheral donor — he was a facilitator, recruiter, and fixer who connected hedge-fund money, Ivy League legitimacy, and political access in a closed loop that insulated all participants from scrutiny. The IPI ecosystem gave Epstein exactly what he needed after Florida: proximity to young academics, international travel, visa sponsorships, and an elite shield that made him look like a disgraced financier turned reformed intellectual benefactor. It wasn't an accident, and it wasn't ignorance — it was a deliberate system where billionaires, former Treasury secretaries, and a convicted predator all found mutual benefit inside the same polished academic machine.to contact  me:bobbycapucci@protonmail.com

Jeffrey Epstein's entanglement with Leon Black and Larry Summers runs through the Jeffrey Epstein VI Foundation and its flagship project, the Institute for New Economic Thinking (INET), born out of the wreckage of the 2008 financial crisis. Black, the billionaire Apollo founder, bankrolled INET with roughly $25 million and installed himself as its chief patron, while Summers — fresh off his controversial presidency at Harvard and a career bouncing between Wall Street and Washington — became one of its intellectual faces. Epstein, already a convicted sex offender by 2008, quietly emerged as a financial conduit and behind-the-scenes broker for INET and its affiliates, using donor networks, shell foundations, and elite access to move money and cultivate influence. Through Epstein's foundation, funds were routed into academic projects, conferences, and research hubs that placed him back inside elite academic circles that had supposedly shut him out, laundering his reputation through economics, philanthropy, and intellectual respectability.What makes the IPI/INET web so corrosive is how thoroughly it fused money, power, and reputational cover. Black would later admit paying Epstein $158 million for “tax advice,” an explanation so implausible it collapsed under its own weight, while Summers maintained institutional ties to projects and donors connected to Epstein long after his 2008 conviction was public record. Epstein was not a peripheral donor — he was a facilitator, recruiter, and fixer who connected hedge-fund money, Ivy League legitimacy, and political access in a closed loop that insulated all participants from scrutiny. The IPI ecosystem gave Epstein exactly what he needed after Florida: proximity to young academics, international travel, visa sponsorships, and an elite shield that made him look like a disgraced financier turned reformed intellectual benefactor. It wasn't an accident, and it wasn't ignorance — it was a deliberate system where billionaires, former Treasury secretaries, and a convicted predator all found mutual benefit inside the same polished academic machine.to contact  me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-moscow-murders-and-more--5852883/support.

En Los Desayunos de Capital, analizamos el escenario de ahorro e inversión de cara a 2026 con Juan de Ipiña, director de Oferta de Mutualidad. En un contexto marcado por el ruido político, la elevada volatilidad de los mercados y las fuertes subidas acumuladas en bolsa en los últimos años, crece el interés de los ahorradores por productos de largo plazo que priorizan la protección del capital y el control del riesgo. Durante la entrevista repasamos el atractivo del PPA y del Plan de Ahorro Sistemático, sus características, fiscalidad, perfil de inversor, expectativas de rentabilidad y liquidez, así como la filosofía de Mutualidad basada en la certidumbre, la prudencia y el ahorro disciplinado, abierta no solo a abogados sino a un público más amplio. En H2 Intereconomía, abordamos el presente y el futuro de la industria con Emma Nogueira y Javier González Pareja, presidente de Bosch en España y Portugal. Bosch hace balance de un 2025 complejo, marcado por tensiones económicas y de mercado, y explica cómo afronta 2026 con una apuesta firme por la innovación. La inteligencia artificial ya es una palanca clave en sus procesos y productos, mientras que el hidrógeno se consolida como uno de los ejes estratégicos de futuro, tanto en la industria como en el transporte. La compañía detalla el camino recorrido desde la investigación hasta los proyectos reales y de gran escala, los retos para activar la demanda y las iniciativas previstas para impulsar el desarrollo del hidrógeno durante el próximo año.

Jeffrey Epstein's entanglement with Leon Black and Larry Summers runs through the Jeffrey Epstein VI Foundation and its flagship project, the Institute for New Economic Thinking (INET), born out of the wreckage of the 2008 financial crisis. Black, the billionaire Apollo founder, bankrolled INET with roughly $25 million and installed himself as its chief patron, while Summers — fresh off his controversial presidency at Harvard and a career bouncing between Wall Street and Washington — became one of its intellectual faces. Epstein, already a convicted sex offender by 2008, quietly emerged as a financial conduit and behind-the-scenes broker for INET and its affiliates, using donor networks, shell foundations, and elite access to move money and cultivate influence. Through Epstein's foundation, funds were routed into academic projects, conferences, and research hubs that placed him back inside elite academic circles that had supposedly shut him out, laundering his reputation through economics, philanthropy, and intellectual respectability.What makes the IPI/INET web so corrosive is how thoroughly it fused money, power, and reputational cover. Black would later admit paying Epstein $158 million for “tax advice,” an explanation so implausible it collapsed under its own weight, while Summers maintained institutional ties to projects and donors connected to Epstein long after his 2008 conviction was public record. Epstein was not a peripheral donor — he was a facilitator, recruiter, and fixer who connected hedge-fund money, Ivy League legitimacy, and political access in a closed loop that insulated all participants from scrutiny. The IPI ecosystem gave Epstein exactly what he needed after Florida: proximity to young academics, international travel, visa sponsorships, and an elite shield that made him look like a disgraced financier turned reformed intellectual benefactor. It wasn't an accident, and it wasn't ignorance — it was a deliberate system where billionaires, former Treasury secretaries, and a convicted predator all found mutual benefit inside the same polished academic machine.to contact  me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

Sometimes you just have an especially bad day. If you are a caregiver who cares for a mom, dad, or spouse with a serious illness like cancer, Alzheimer's disease, other dementia illnesses, or ALS you may be familiar with caregiver stress and you've probably had multiple especially bad days.How do you handle them? What works to reduce your suffering?On this week's episode of The Integrative Palliative Podcast Dr. Delia discusses 6 approaches to reducing your suffering when you are facing an especially bad day.#caregiver #caregiving #badday #palliativeWww.DoctorDelia.com Coping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

When you visit your ill or aging parents over the holidays, you might be in for a surprise. Maybe your mom seems confused or your dad is having trouble with driving. Maybe you're not sure if the changes you're seeing are something to worry about or are just normal aging. What should you look for? What should you worry about? What changes are not actually concerning?In this episode of The Integrative Palliative Podcast, Dr. Delia Chiaramonte discusses what to look for when you visit your aging parents and when you should worry.Do you know someone with an aging parent? Send them this episode.Knowledge is power.Happy holidays!Dr. DeliaDelia Chiaramonte, MDhttps://www.doctordelia.comCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Some people have wonderful experiences with hospice, and other people say the experience was terrible. What's the difference?If your loved one is sick enough to need hospice, it's a highly stressful time for your whole family. Whether your loved one has cancer, dementia, ALS, COPD or another serious illness, making the decision for when to request hospice care is tough.Once you've made the decision to start hospice, how do you make sure that your loved one and your family get the very best hospice care? In this episode we discuss the 10 ways to be sure you get the very best hospice care.Caring for you as you care for them.Dr. Deliahttps://doctordelia.comBe sure to subscribe to The Integrative Palliative Podcast here: https://podcasts.apple.com/us/podcast/the-integrative-palliative-podcast/id1617730043Coping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Grief is tough. It is so very hard when a loved one dies. Whether it is expected because of serious illness or a total shock, grief is painful. And also, grief is part of life. Sometimes people compound their suffering by asking "Why am I still grieving so hard?" or "Shouldn't I be better by now?"Trying to push grief away doesn't help. In fact, it can make grieving even harder. This meditation is an invitation to make peace with grief.If you have ever lost a person, a pet, a prized possession, a job, an identity, or anything else, this meditation is for you.Be sure you're in a safe place (no driving!) when you listen.I'm glad you're here.Doctor Deliawww.DoctorDelia.comCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Facing a serious loss after a loved one has died is just so tough. Without meaning to we can compound the stress of it all by how we approach our grief.The mindful approach to grief involves noticing, not judging, and using compassionate curiosity. It makes space for grief because grief is part of life and love. Here is the reference mentioned in the episode: Huang FY, et al. Mindfulness-based cognitive therapy on bereavement grief: Alterations of resting-state network connectivity associate with changes of anxiety and mindfulness. Hum Brain Mapp. 2021 Feb 1;42(2):510-520. I'm glad you're here.Dr. Deliawww.integrativepalliative.comwww.DoctorDelia.com (coming soon)Coping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Welcome back to the Alt Goes Mainstream podcast.Today's episode dives into digital infrastructure and how it powers the growth of artificial intelligence and other major trends in digitalization and electrification.We sat down in Blue Owl's NYC office with Matt A'Hearn, an asset management entrepreneur and executive at the firm.Matt is a Senior Managing Direct at Blue Owl and Head of Digital Infrastructure. He's responsible for leading the overall management of Digital Infrastructure, including strategy, investments, and portfolio management.Prior to joining Blue Owl, Matt was the Managing Partner and a Founder of IPI Partners, the predecessor firm to Blue Owl Digital Infrastructure. IPI was acquired by Blue Owl in 2024.Prior to founding IPI, Matt led the global investment banking practice in communications infrastructure at Moelis & Company.Matt and I had a fascinating and thought-provoking discussion about the future of digital infrastructure. We covered:The how and the why of digital infrastructure.Investing in data centers.The evolution of digital infrastructure.How to best partner with and serve the need of hyperscalers.The importance of power generation for AI. How there are different ways to approach gaining exposure to AI as an investment theme.Thanks Matt for coming on the show to share your wisdom and expertise in private markets and digital infrastructure.A word from AGM podcast sponsor, Ultimus Fund SolutionsThis episode of Alt Goes Mainstream is brought to you by Ultimus Fund Solutions, a leading full-service fund administrator for asset managers in private and public markets. As private markets continue to move into the mainstream, the industry requires infrastructure solutions that help funds and investors keep pace. In an increasingly sophisticated financial marketplace, investment managers must navigate a growing array of challenges: elaborate fund structures, specialized strategies, evolving compliance requirements, a growing need for sophisticated reporting, and intensifying demands for transparency.To assist with these challenging opportunities, more and more fund sponsors and asset managers are turning to Ultimus, a leading service provider that blends high tech and high touch in unique and customized fund administration and middle office solutions for a diverse and growing universe of over 450 clients and 1,800 funds, representing $500 billion assets under administration, all handled by a team of over 1,000 professionals. Ultimus offers a wide range of capabilities across registered funds, private funds and public plans, as well as outsourced middle office services. Delivering operational excellence, Ultimus helps firms manage the ever-changing regulatory environment while meeting the needs of their institutional and retail investors. Ultimus provides comprehensive operational support and fund governance services to help managers successfully launch retail alternative products.Visit www.ultimusfundsolutions.com to learn more about Ultimus' technology enhanced services and solutions or contact Ultimus Executive Vice President of Business Development Gary Harris on email at gharris@ultimusfundsolutions.com.We thank Ultimus for their support of alts going mainstream.Show Notes00:00 Our Sponsor, Ultimus01:57 Welcome to the Alt Goes Mainstream Podcast02:05 Guest Introduction: Matt A'Hearn03:36 Evolution of Digital Infrastructure04:02 Founding IPI Partners04:15 Digital Infrastructure and AI05:35 Early Challenges in Data Center Investing06:13 Cloud Growth and Hyperscale Companies07:05 Partnerships with Hyperscalers08:07 Financing Hyperscalers10:14 AI and Cloud: A Generational Opportunity11:51 Supply and Demand Dynamics in AI13:21 Power and Infrastructure Challenges14:55 Site Selection and Power Considerations17:53 Scale and Capital Requirements22:32 Data Center Capacity Needs23:35 Investment Opportunities in Digital Infrastructure24:21 Blue Owl's Capital Strategy26:25 The Blue Owl Transaction26:35 Capital Needs in the Industry26:58 Feedback from Hyperscalers27:18 Joining Blue Owl27:51 Founding IPI28:50 Building the Firm30:38 Differentiating IPI31:36 Early AI Insights32:26 AI and Cloud Growth34:41 Investment Opportunities in Digital Infrastructure35:27 Risk-Adjusted Investment Strategies36:39 Underwriting Digital Infrastructure38:22 Capital Allocation in Tech Companies39:17 Meta and Data Center Development40:41 Alternative Asset Management in Tech41:45 Merging Investment Cultures43:19 Challenges and Opportunities43:53 Wealth Channel Expansion45:51 Evergreen Structures and Long-Term Investments50:50 Future of Digital InfrastructureEditing and post-production work for this episode was provided by The Podcast Consultant.

Kevin Rudd's connection to Jeffrey Epstein is a textbook example of elite hypocrisy masquerading as moral leadership. As chairman of the International Peace Institute, Rudd oversaw an organization that accepted roughly $650,000 in donations from Epstein-linked foundations—years after Epstein was already a convicted sex offender. That's not an oversight; that's willful blindness wrapped in plausible deniability. Rudd claimed he was “deeply disappointed” when the donations surfaced, but disappointment isn't accountability. Under his watch, the IPI took dirty money from a known predator whose crimes were public record, and the excuse that he “acted immediately” once the donations were exposed reeks of retroactive reputation management. If Rudd was truly blindsided, it's because he didn't care to look. Epstein's money was good enough for the IPI until the headlines changed.to contact me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

Confira na edição de Os Pingos nos Is desta quarta-feira (08):O Congresso Nacional rejeitou a “MP Taxa Tudo”, Medida Provisória considerada crucial pelo governo Lula. Com a derrota, o aumento de impostos que renderia R$ 17 bilhões em 2026 foi barrado.Após o revés no Congresso, o governo de Lula (PT) pode “atropelar” o Legislativo e aumentar impostos por decreto. O STF já reconheceu a autonomia do Executivo para elevar a alíquota de tributos extrafiscais, como IOF e IPI, sem necessidade de aprovação parlamentar.O advogado Martin Luca, ligado ao presidente Donald Trump, alertou o governo Lula sobre as negociações do tarifaço e reiterou que os Estados Unidos exigem mudanças do Brasil.O presidente do Senado, Davi Alcolumbre (União-AP), deu um duro golpe na oposição ao afirmar que “não há clima” na Casa para votar o PL da Dosimetria — projeto que prevê a redução de penas para os envolvidos nos atos de 8 de janeiro.O Centrão iniciou a punição de ministros que se recusaram a deixar o governo Lula após o rompimento oficial. O ministro André Fufuca (PP-MA) foi afastado do partido, enquanto Celso Sabino (União-PA) corre risco de expulsão do União Brasil.Você confere essas e outras notícias em Os Pingos nos Is.

Caregiving doesn't just happen in the current moment - it brings old family roles that we've been playing out since childhood back to life. The "responsible one" burns out, and the "favorite" expects everyone to defer to them. The "ghost" fades into the background, and the "rebel" resists every decision. In this episode Dr. Delia Chiaramonte explores the hidden scripts that siblings carry into caregiving, why they cause so much conflict, and how you can step out of those roles instead of letting them cause stress and chaos.Once you see your "script" you can start to write a new one.What role do you play?www.integrativepalliative.comCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Jeffrey Epstein was a steady political donor for years, spreading money across both parties while cultivating influence. From 1989 to 2003, he gave more than $139,000 to Democrats and over $18,000 to Republicans, often in relatively small increments that added up over time. His contributions included donations to figures like Chuck Schumer in the 1990s and a $50,000 check to Bill Richardson's 2002 gubernatorial campaign in New Mexico. Beyond politics, Epstein also positioned himself as a benefactor in academic and cultural circles, with his foundations giving more than $30 million to universities and institutions, furthering his attempts to launder legitimacy and credibility through philanthropy.Epstein's financial ties also reached organizations connected to the United Nations. The International Peace Institute (IPI), a think tank closely tied to the UN, received donations from his network, prompting scandal years later when it was revealed the contributions were not fully disclosed. In 2020, IPI president Terje Rød-Larsen resigned after admitting to accepting Epstein-linked funds, even as he claimed they represented only a small portion of IPI's budget. Reports also show Epstein helped facilitate or influence funding for UN-affiliated projects alongside other wealthy donors, such as through connections with the Bill & Melinda Gates Foundation. While these donations may not have gone directly to the UN itself, they highlight how Epstein used philanthropy and political giving to maintain access to power.to contact me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-moscow-murders-and-more--5852883/support.

Jeffrey Epstein was a steady political donor for years, spreading money across both parties while cultivating influence. From 1989 to 2003, he gave more than $139,000 to Democrats and over $18,000 to Republicans, often in relatively small increments that added up over time. His contributions included donations to figures like Chuck Schumer in the 1990s and a $50,000 check to Bill Richardson's 2002 gubernatorial campaign in New Mexico. Beyond politics, Epstein also positioned himself as a benefactor in academic and cultural circles, with his foundations giving more than $30 million to universities and institutions, furthering his attempts to launder legitimacy and credibility through philanthropy.Epstein's financial ties also reached organizations connected to the United Nations. The International Peace Institute (IPI), a think tank closely tied to the UN, received donations from his network, prompting scandal years later when it was revealed the contributions were not fully disclosed. In 2020, IPI president Terje Rød-Larsen resigned after admitting to accepting Epstein-linked funds, even as he claimed they represented only a small portion of IPI's budget. Reports also show Epstein helped facilitate or influence funding for UN-affiliated projects alongside other wealthy donors, such as through connections with the Bill & Melinda Gates Foundation. While these donations may not have gone directly to the UN itself, they highlight how Epstein used philanthropy and political giving to maintain access to power.to contact me:bobbycapucci@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

When someone is nearing the end of life, the idea of leaving behind a “goodbye” or legacy letter can feel meaningful, but also overwhelming. What do you say? How do you start? In this episode, Dr. Delia offers a gentle guide to writing a letter that captures your love, gratitude, and wisdom without the pressure to be perfect.You'll learn:Why legacy letters matter so deeply for both the writer and the readerSimple tips to make the process less overwhelmingTen powerful prompts to spark your writing — from sharing what you've cherished in your life to what you love most about your personWhether you're a patient, a caregiver, or simply someone who wants to capture your story for those you love, this episode will help you find the right words.Coping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

We all need this episode. Whether you're a family caregiver, caring for an ill or aging loved one, or you're a busy clinician who cares for seriously ill patients, this episode is for you.Michael L Smith shares his wisdom and inspirational guidance about how we all block the love that we deserve and how we can learn to receive it.Michael is a visionary author, speaker, and transformational guide whose life's work bridges love, longevity, holistic well-being, and human potential. Michael has devoted his life to helping people remember their individual and collective wholeness, holiness, and sacred purpose.His journey has been shaped by profound personal experiences, including the loss of his brother Ric (52), which deepened his calling to explore love not as an abstract ideal but as a living medicine for the heart, gut, mind, body and soul. Through books, courses, retreats, and public talks, he weaves science, spirituality, and lived wisdom into practical pathways for personal transformation and collective healing.Michael's forthcoming book, How to Receive Love: Your Heart & Soul's Purpose, and its companion programs aim to ignite a global movement of self-love, deep connection, and inspired service. You can find Michael at https://receivelove.com/Have a listen and soothe your soul.Dr. DeliaP.S., Join our private Facebook group "CareWell for Caregivers"www.doctordelia.comCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Caring for a parent who is aging or who has dementia, debility, or serious illness such as cancer can be absolutely exhausting. It can feel like you're hanging on by your fingernails. This week on The Integrative Palliative Podcast we're talking about 15 ways to help you care for yourself as you care for your aging parent.Your wellbeing matters too.- Dr. Deliawww.integrativepalliative.comJoin our Facebook Group, CareWell for CaregiversCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

According to the investigation by Dagens Næringsliv (DN), Jeffrey Epstein played a pivotal and active role in securing millions of dollars in funding from the Bill & Melinda Gates Foundation to the International Peace Institute (IPI), a UN-affiliated think tank headed by Terje Rød-Larsen. In 2013, Epstein arranged and facilitated a meeting between Bill Gates and Rød-Larsen at the Oslo home of Thorbjørn Jagland, then chair of the Nobel Peace Prize Committee. Emails revealed that Epstein gave Rød-Larsen specific instructions on how to frame the conversation with Gates and pushed aggressively behind the scenes to help IPI receive significant grant money. Following this interaction, IPI received a $2.5 million donation from the Gates Foundation, with additional payments totaling several million more over the years.His involvement raised serious questions, especially in light of his conviction years earlier for sex offenses involving minors. Despite this, he retained enough standing with Gates and IPI leadership to broker philanthropic deals at the highest levels. The investigation paints a clear picture: Epstein wasn't just collecting names—he was actively leveraging them to embed himself in elite diplomatic and philanthropic networks, even after his criminal record was public knowledge.to contact me:bobbycapucci@protonmail.comsource:https://www.dn.no/politikk/terje-rod-larsen/bill-gates/jeffrey-epstein/behind-the-scenes-how-jeffrey-epstein-helped-billionaire-bill-gates-fund-un-affiliated-think-tank-projects/2-1-885697

If your parent has cancer, dementia, serious illness, or is just declining because they're getting older, you may feel the urge to help them as they get weaker. Perhaps you make space in your busy life, juggle responsibilities with both your parents and your kids, research the best care, and just try your best to show up for your parents. When you do all that it can be shocking and frustrating if your parents rebuff your efforts to help.This week on The Integrative Palliative Podcast I share 20 things that you can do if your parents won't accept your help.Thanks for all that you do!Dr. DeliaDelia Chiaramonte, MDwww.integrativepalliative.comCoping Courageously: A Heart-Centered Guide for Navigating a Loved One's Illness Without Losing Yourself is available here: www.copingcourageously.com Please review this podcast wherever you listen and forward your favorite episode to a friend! And be sure to subscribe!Sign up to stay connected and learn about upcoming programs:https://trainings.integrativepalliative.com/IPI-stay-in-touchI'm thrilled to be listed in Feedspot's top 15 palliative podcasts!https://blog.feedspot.com/palliative_care_podcasts/

Leon Black, the former cofounder of Apollo Global Management with deep ties to Jeffrey Epstein, has donated significant sums to the IPI—reportedly at least $950,000—in a pattern that closely mirrors Epstein's own shadowy funding of the institute. Even though Black has attempted to distance himself publicly, the conduit appears to have been deliberately opaque: donations through intermediaries, anonymity, and minimal disclosure have raised flags among those investigating Epstein's network. These contributions come under scrutiny not only because Epstein was involved in brokering them but also because the donations were structured to conceal the true source and avoid public recognition.Meanwhile, Senate Finance Committee Ranking Member Ron Wyden has escalated concerns by requesting documents from the DOJ, Treasury, and FBI about Black's financing of Epstein's operations. Wyden's investigation revealed that Black transferred at least $170 million to Epstein between 2012 and 2017—far exceeding the $158 million previously acknowledged—and that some of those funds directly supported Epstein's operations in the U.S. Virgin Islands. In 2023, Black settled claims with the USVI by paying $62.5 million—a case that stated some of his payments were used to fund Epstein's illicit activities on Little St. James Island. Critics argue that the use of IPI and other charitable vehicles to mask these funds reflects a deliberate effort to launder legitimacy onto Epstein's network.to contact me:bobbycapucci@protonmail.comsource:https://www.dn.no/politikk/the-international-peace-institute/jeffrey-epstein/terje-rod-larsen/leon-black-did-like-his-adviser-jeffrey-epstein-gave-anonymously-to-un-affiliated-think-tank/2-1-897114

Leon Black, the former cofounder of Apollo Global Management with deep ties to Jeffrey Epstein, has donated significant sums to the IPI—reportedly at least $950,000—in a pattern that closely mirrors Epstein's own shadowy funding of the institute. Even though Black has attempted to distance himself publicly, the conduit appears to have been deliberately opaque: donations through intermediaries, anonymity, and minimal disclosure have raised flags among those investigating Epstein's network. These contributions come under scrutiny not only because Epstein was involved in brokering them but also because the donations were structured to conceal the true source and avoid public recognition.Meanwhile, Senate Finance Committee Ranking Member Ron Wyden has escalated concerns by requesting documents from the DOJ, Treasury, and FBI about Black's financing of Epstein's operations. Wyden's investigation revealed that Black transferred at least $170 million to Epstein between 2012 and 2017—far exceeding the $158 million previously acknowledged—and that some of those funds directly supported Epstein's operations in the U.S. Virgin Islands. In 2023, Black settled claims with the USVI by paying $62.5 million—a case that stated some of his payments were used to fund Epstein's illicit activities on Little St. James Island. Critics argue that the use of IPI and other charitable vehicles to mask these funds reflects a deliberate effort to launder legitimacy onto Epstein's network.to contact me:bobbycapucci@protonmail.comsource:https://www.dn.no/politikk/the-international-peace-institute/jeffrey-epstein/terje-rod-larsen/leon-black-did-like-his-adviser-jeffrey-epstein-gave-anonymously-to-un-affiliated-think-tank/2-1-897114Become a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

Morning news...wow, you have to love CONSTRUCTION SEASON...how many detours?? Tom Giovanetti from IPI dot org talks the Trump Tariffs, and a big financial danger that courts might deal him. Interesting talk.

Friday, July 18, 2025 Welcome to our Weekend Edition with host Kerby Anderson. His co-hosts are Dr. Merrill “Buddy” Matthews, Resident Scholar at IPI and our own Penna Dexter. They'll cover the top stories from today. Connect with us on Facebook at facebook.com/pointofviewradio and on Twitter @PointofViewRTS with your opinions or comments. Looking for just […]

Friday, July 18, 2025 Welcome to our Weekend Edition with host Kerby Anderson. His co-hosts are Dr. Merrill “Buddy” Matthews, Resident Scholar at IPI and our own Penna Dexter. They'll cover the top stories from today. Connect with us on Facebook at facebook.com/pointofviewradio and on Twitter @PointofViewRTS with your opinions or comments. Looking for just […]

Will Van Derveer, MD is a psychiatrist and leader in the field of integrative mental health care. After starting a psychiatry practice in 2002, Dr. Van Derveer soon discovered the grave limitations of conventional psychiatry.Over the next decade of clinical care, he gradually introduced integrative interventions such as gut-brain axis interventions, microbiome analysis, hormone balancing, mindfulness practice, exercise and diet prescriptions, as well as psychedelic therapy into his work. He co-founded Integrative Psychiatry Institute (IPI) to deliver education for mental health practitioners in advanced tools for resolving the root causes of symptoms often missed in conventional care settings. The IPI year long psychedelic-assisted therapy training is the gold standard training in this emerging field, having graduated more than 2000 licensed professionals. Dr. Van Derveer's innovations in the field of integrative mental healthcare are fueled by his conviction that anyone can heal if provided the right combination of support.In addition to his clinical practice and teaching, he has staffed several studies sponsored by Multidisciplinary Association for Psychedelic Studies, investigating MDMA-assisted psychotherapy for chronic, treatment-resistant PTSD. Dr. Van Derveer is co host of the Higher Practice Podcast for optimal mental health, and his first book, Psychedelic Therapy, with a foreword by Gabor Mate, will be published by Shambhala Publications in early 2026.He is a graduate of Vanderbilt University Medical School and completed psychiatry residency training at the University of Colorado.https://www.linkedin.com/in/will-van-derveer-md/IG @will.vanderveer.mdFB https://www.facebook.com/will.vanderveer.md

This episode covers:In this episode, we discuss the #1 ingredient to avoid for mental health, who may benefit from psychedelic therapy, how trauma, toxins, and lifestyle can impact your mind, and so much more.Will Van Derveer, MD is co-founder of Integrative Psychiatry Institute (IPI), along with friend and colleague Keith Kurlander, MA. He co-created IPI as an expression of what he stands for. First, that anyone can heal, and second that we medical providers must embrace our own healing journeys in order to fully command our potency as healers.Dr. Van Derveer spent the last 20 years innovating and testing a comprehensive approach to addressing psychiatric challenges which transcends the conventional model he learned in medical school at Vanderbilt University and residency at University of Colorado, while deeply engaging his own healing path.He founded the Integrative Psychiatric Healing Center in in 2001 in Boulder, CO, where he currently practices. Dr. Van Derveer regards unresolved emotional trauma as the most significant root cause of psychiatric symptoms in integrative psychiatry practice, along with gut issues, hormone imbalances, inflammation, mitochondrial dysfunction, and other functional medicine challenges. He is trained in Somatic Experiencing, EMDR, Internal Family Systems, and other psychotherapy techniques. His current clinical passion is psychedelic-assisted psychotherapy, which he mentors interested doctors in providing. An avid meditator, he has been a meditation instructor since 2004.Links mentioned during this episode:Dr. Van Derveer's Instagram: https://www.instagram.com/will.vanderveer.md/?hl=enIPI Website: https://psychiatryinstitute.com/Dr. Van Derveer's Podcast: https://psychiatryinstitute.com/podcast/Root Cause of Depression Map from Dr. Van Derveer: https://drive.google.com/file/d/1URYlUYd_yyAQEt3Hdj4xQzm-kmoCoGaS/view?usp=sharingFree Initial Consultation with Dr. Megan: https://p.bttr.to/3a9lfYkLyons' Share Instagram: www.instagram.com/thelyonsshareJoin Megan's Newsletter: www.thelyonsshare.org/newsletter