Podcasts about ardem patapoutian

Piezo touch and pressure-sensing ion channels are showing up everywhere as the explanation for physiologic phenomena, both at the macro and micro levels. Ardem Patapoutian, my friend and colleague at Scripps Research, discovered these receptors back in 2010 and was awarded the Nobel Prize in 2021 for his work. As you'll see/hear from our conversation, the field has exploded. And you'll get to know Ardem, who is such a fun, charismatic, and down-to-earth person. He also recently got a unique tattoo (videos below) and I wonder (unlikely) if any other Nobel laureates have one related to their discovery?!Below is a video clip from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The current one is here. If you like the YouTube format, please subscribe! The audios are also available on Apple and Spotify.Transcript with links to audioEric Topol (00:07):Well, hello. It's Eric Topol with Ground Truths, and I've really got a special guest today. The first time for the podcast, I've been able to interview a colleague and faculty at Scripps Research, Ardem Patapoutian, who just by the way happens to be the 2021 Nobel Laureate in Physiology or Medicine. So welcome, Ardem. It's so wonderful to have you.Ardem Patapoutian (00:30):Thanks so much, Eric. Looking forward to chatting with you.Eric Topol (00:34):Well, this has been interesting because although I've known you for several years, I didn't research you. I mean, I had to learn about more than I even do. And of course, one of the great sources of that is on the Nobel Prize website where you tell your whole story. It is quite a story and not to review all of it, but I wanted to go back just before you made the call to move to Los Angeles from Beirut, Lebanon and with the scare that you went through at that time, it seemed like that was just extraordinary that you had to live through that.Ardem Patapoutian (01:11):Yeah, so I am of Armenian origin, but I was born in Lebanon and born in 1967, so I was eight years old when the civil war started. So it's a kind of bizarre childhood in the sense that with all the bombs and fighting in Lebanon. So it was tough childhood to have, but it was never personal. It was bombs and such. And so, the event you're talking about is, I happened to be kidnapped while crossing East to West Beirut. They only held me for four or five hours at first asking me questions to see who I am, but I think they pretty soon figured out that I was not a dangerous guy and they ended up letting me go. But before that, that incident really had a huge impact on me so that by the time I got home, I literally said, I'm out of here. I'm going to find a way to leave the country. And so, that's what, very quickly within a few months I packed and came to United States.Eric Topol (02:19):And how did you pick LA to be your destination?Ardem Patapoutian (02:22):Being from the Armenian community, there's a lot of Armenians in Los Angeles. My cousins already had moved there. They also grew up in Lebanon. And my brother, who's a few years older than me, got admitted to USC graduate school in engineering. So he was going to be there. So it made a lot of sense.Eric Topol (02:44):Oh yeah.Ardem Patapoutian (02:45):Unlike him, I came with no school or job prospects because it happened so fast that I kind of just left. One year I was at American University of Beirut for one year, but then just left and came here. So worked for a year in various jobs and then started going back to school to UCLA.Eric Topol (03:07):Yeah, I saw how there was about a year where you were delivering pizzas and before you got into UCLA, and that must have been an interesting off year, if you will. Well, the story of course, just to fast forward, you did your baccalaureate at UCLA, your PhD at Caltech, postdoc at UCSF, and then you came to Scripps Research 24 years ago along with Pete Schultz, and it's been quite an amazing run that you've had. Now, before we get into PIEZO receptors, the background, maybe you could help me understand, the precursor work seems to be all related to the transient receptor potential (TRP) series, also ion channels. They were of course related to whether it was heat and temperature or somatosensory. How do these channels compare to the ones that you discovered years later?Background on these Ion ChannelsArdem Patapoutian (04:09):Yeah, so the somatosensory neurons that innervate your fingertips and everywhere else in your body, their main job is to sense temperature and pressure. And this is very different than any other neuron or any other cell. So when you touch a hot stove that's burning hot, you need to know about that immediately within milliseconds or something cold. So the opposite side of it is pressure sensing, and it also comes in light touch, which is pleasant or a hammer hitting your finger, which is unpleasant. But all of these have the same characteristic anyway, that is your body has learned at the molecular level to translate a physical stimulus such as temperature and pressure into an electrical signal that neurons use to communicate with each other. But this idea of how you translate physical stimuli into chemical or electrical signal has been a long open question because as you know, most of our cells communicate by chemicals, whether that's hormones or small molecules, we know how that works, receptor bind to ligand, confirmational change and you get a kinase activation and that's enough. But here, how do you sense pressure? How do you sense temperature? It was just, there wasn't much known about that. And that's why our earlier work on TRP channels, which were temperature sensors came before the pressure. And so, they're very related in that sense.Eric Topol (05:52):The structure of these, if you were to look at them, do they look pretty similar? What the TRP as you say, and what you did back in the 2010 Science paper, which we'll link to, of course the classic paper where you describe PIEZO1 and PIEZO2, but if you were to look at this structures, would they look pretty similar?Ardem Patapoutian (06:14):No, that's a good question. And they absolutely don't. That's why finding these receptors were so hard. So if you go back to other sensory receptors, vision rhodopsin G-protein coupled receptor (GPCRs), larger G-protein coupled receptor look the same. So for example, when it was identified by chemically, that smell also works through G-protein coupled receptor. Richard Axel and Linda Buck, who also won the Nobel Prize, found those receptors by homology to visual GPCRs. The ion channels other than the fact that they crossed the membrane a few times or more, they have nothing else in common. If you looked at their structure, you can't even immediately tell they're ion channels. So you couldn't find these by structural homology or sequence homology. So you had to do something else. And usually that means functional screens and et cetera.Eric Topol (07:09):Well, yeah, and I'm in touch with the screening. We'll get to that and how you dig these up and find them. But the somatosensory ones are really interesting because I don't think a lot of people realize that when you have wasabi or you have Listerine mouthwash and feel the burn and that these are all mediated through these channels, right?Ardem Patapoutian (07:35):Yeah. So there's this whole field of chemesthesis, which means senses in your mouth, for example, that are not explained by taste transduction and olfactory. And these are actually by the same somatosensory neurons that help you sense temperature and pressure. And some of these receptors are the same. Their evolution has taken over and used them for many different things. The prime example of this is the capsaicin receptor that David Julius my co-laureate identified, which is also heat receptors. So all languages describe chili peppers as hot, and that's not a coincidence. It actually activates heat activated channel, and that's why we think of it as hot. And so, the same goes to another one of these TRP channels that you mentioned, which is TRPA1, and this one is also activated, but a lot of spicy foods other than the chili pepper active ingredient includes what's in garlic and onions and everything that has this burning sensation and chemicals of this and wasabi and chemicals of this are used in over the counter products like Listerine that cause that burning sensation.Eric Topol (08:54):So when you're chopping onions and it makes you cry, is that all part of it as well?Ardem Patapoutian (08:59):That's all TRPA1, yeah.The Discovery, A Test of PerseveranceEric Topol (09:01):It's wild. Now, this was the groundwork. There were these heat temperature and somatic sensory, and then you were starting to wonder what about touch, what about out pressure and proprioception. And so, you went on a hunt, and it's actually kind of an incredible story about how you were able to find out of these cells that you had, screening hundreds or I guess you got to 72 different small interfering RNA blocking that you finally found the one. Is that right?Ardem Patapoutian (09:37):That's right. So in retrospect, looking back at it, I think there's such an interesting scientific message there. And so, many of us were looking for this touch pressure sensors and we were all looking in the DRG sensory neurons that are complicated heterogeneous, they don't divide. It's not easy to do a screen on them. And ultimately after a lot of failures, what worked for us is to take a step back and ask a much more simpler question. And that was, can we find one of these cell lines that you could easily homogeneously grow in a culture dish, if they respond to mechanical force, can we find our channel there? And then go back and look if it's relevant in vivo for what process. So I think the message is ask the simplest question to answer the question you're after. And finding what that is, is actually the challenge lots of times.Ardem Patapoutian (10:36):But yeah, that's what Bertrand Coste in my lab did is found a simple cell line that neuroscientists had been using for a hundred years and somehow found that they over overexpressed this channel because you can record from them, you can push them and record the currents from them. And then it became a simpler question of finding it. It still took a whole year. He made a list and one by one knocking them out and looking at it. And finally, as you say, number 72 was the hit. When he knocked that out, the current was gone. And that's where we started believing that we have what we were looking for.Eric Topol (11:12):Were you all ever about ready to give up at that point?Ardem Patapoutian (11:16):Oh yeah. I mean that's another lesson. These are postdocs doing the work, right? And they're here three, four years and this was coming close to end of two years, and he didn't have anything yet. So we started talking about having a backup project and he started that and we said, okay, we were ordering this oligos 30 at a time because they're expensive. And so, the first 30 nothing, the second 30 nothing. And how many more are we going to do before we potentially give up? And we said, well, let's do at least a third and then decide, thank goodness it was in that last set.Eric Topol (11:54):Wow, that is so wild. Now what's happened since this discovery, which I guess when you published it in 2010, so it means 14 years ago, but we're on this exponential growth of learning that these piezo receptors are everywhere. They're doing everything. In fact, I recently put on Bluesky, PIEZO ion channels are to human physiology as GLP-1 drugs are to treating many diseases because it's just blowing up. And you've published on some of these of course, on itch and bladder function and vascular function. We'll get to maybe malaria, I mean, but even the cover of Science recently was about wet dog shakes and how animals shake because of water. These receptors are so fundamental to our function. So maybe you could comment, 15 years ago when you were doing the work and you're making this discovery, did you ever envision it was going to blow up like this?Ardem Patapoutian (12:57):Not to this level, but I should have. I think that this idea, again, that most of cell communication is through chemicals is of course a lot of it is true.Ardem Patapoutian (13:12):But it would be ridiculous for evolution to ignore all the physical forces, the pressures that cells experience. And once they do, you would think you would put an instructive way of sensing this pressure signal and using it beneficially to the system or the cell. And so, when we used to talk about pressure sensing at the beginning, there were a couple of touch, pain, maybe proprioception, hearing are like the poster children of pressure sensing. But I think what these molecules, as you say is enabling us is finding out the much more wider role that pressure sensing is playing in physiology and in disease that no one had thought seriously about. And this is, I compare sometimes the finding the PIEZO molecules. You're going in a dark room, and you need to find a door to get into there. And PIEZO is kind of that finding the door once you get in, now you use that molecule now to find physiology instead of the opposite way around. So by pursuing PIEZO expression and function, we're finding all these new roles that they play in physiology and in disease that we didn't think about. And because they're so specialized to sense tension, membrane tension, they don't do anything else. So if you see them expressed somewhere or if you see a function for them, you can bet that they are playing a role in sensing pressure. A lot of biology has kind of come from this hypothesis.Eric Topol (15:00):Well, I mean it is so striking to see the pervasiveness, and I do want to go back just for a second because when you name them PIEZO, you named it after the Greek word. How did you come to that name?Ardem Patapoutian (15:13):So Bertrand and I were actually sitting on Google Translate and we were typing pressure and trying to see what it's like in Greek or in Latin or different languages. His native French and my Armenian and píesi in Greek is pressure. And of course, what's really cool is that the word that more people know about this is piezoelectric device.Eric Topol (15:41):Oh, right.Ardem Patapoutian (15:41):Actually, translates physical force into electricity and vice versa. And in a way, this is a little molecular machine that does the same thing, and he uses this piezoelectric device to actually push on the cell. That's his assay. So it all came together as a very appropriate name for this gene and protein.Call from the Nobel CommitteeEric Topol (16:04):Oh really, it's perfect. And you get to name it, even that's fun too, right? Now we're going to go to getting the call at 2:00 AM, but it didn't come to you because your phone from the Nobel Committee was on ‘do not disturb' and your 94-year-old father, Sarkis. How did the Nobel Committee know to get ahold of him? How did they reach him in the middle of the night?Ardem Patapoutian (16:37):Yeah, so I mean, since receiving it, I've had conversations with various committee members, and they are very resourceful folks, and they have assistants who throughout the year collect information on all potential people who might win. They're also doing last minute searches. So they looked for other Patapoutian's in California. So they just called my dad who initially yelled at them for disturbing him at 2:00 AM.Eric Topol (17:17):And he could get through to you because he was not on your list of ‘do not disturb' or something like that.Ardem Patapoutian (17:22):I didn't even know this. And I don't know if the policy has changed, but in some phones the ‘do not disturb' if it's called by someone who's in your contacts or favorites.Ardem Patapoutian (17:34):After I think they called twice and they get through, and that's how.Getting a Tattoo!Eric Topol (17:39):That's amazing. Wow. Well, that's quite a way to find out that you're getting recognized like this. Now recently you got a tattoo, which I thought was really remarkable, but we're going to put that of course in the post. Tell us about your decision to get the PIEZO channel on your arm.Ardem Patapoutian (18:02):So as you can tell, I'm obsessed about PIEZO and it's been good to me. And I had the idea a while ago, and my very wise wife, Nancy Hong, said that you might be going through midlife crisis. Why don't you wait a year? If you still believe in it, you should do it. And that's what I did. I waited a year, and I was like, I still want to do it. And I guess I could show it. Here it is.Eric Topol (18:32):Oh yeah, there it is. Oh wow.Ardem Patapoutian (18:33):What's cool is that I can pretty much flex to show the activation mechanism because the channel is like bent like this in the plasma membrane. When it's stretched, it opens and it actually flattens like this. So I feel like other than being a tattoo, this is both performance art and instructional device. When I'm giving talks without PowerPoint slides, I could give a demonstration how this ion channel works.[Below is from a presentation that Ardem recently gave, the Harvey Lecture, at Rockefeller University.]Eric Topol (19:04):It's wild. Now how did you find a tattoo artist that could, I mean, it's pretty intricate. I mean, that's not your typical tattoo.Ardem Patapoutian (19:14):Yeah, I put it up on social media that I was thinking of doing this, and many scientists are into tattoos, so I actually got so many recommendations. And one of them was a local here in San Diego, and she is very popular. I waited six months to get this, I was on a waiting list. The appointment was six months off when we made it. So she's very popular and she's very good.Eric Topol (19:45):Was it painful to get that done?Ardem Patapoutian (19:47):Well, that's actually really cool, right? Because PIEZO2 is involved in pain sensation, and I felt it while it was being tattooed on my arm. The whole day, I was there like six and a half hours.New Prospect for Pain MedicationEric Topol (20:00):Oh my gosh. Wow. Now that gets me to pain because, I'd like you to talk a bit about the people that don't have mutations or loss of function PIEZO receptors and also what your thoughts are in the future as to maybe we could develop a lot better pain medications.Ardem Patapoutian (20:22):Yeah, we're working on it. So you're right. One of the great parts of the science story, and this is mainly the work of Alex Chesler and Carsten Bönnemann at the NIH, where they identified people who came to the clinic for undiagnosed conditions, and they were uncoordinated and had difficulty walking. And when they did whole-exome sequencing, they found that they had mutations in PIEZO2, there were loss of function, as you say. So complete loss on both chromosomes. And when they started testing them, they realized that just like we had described them in animal models, humans without PIEZO2 as well, didn't sense touch, don't have proprioception. This sense of where your limbs are, that's so important for balance and most other daily functions that we take it for granted. So they were completely lacking all of those sensations. They also do not feel their bladder filling.Ardem Patapoutian (21:26):And so, they have learned to go on a schedule to make sure they don't have accidents. And many of these projects that we've done in the lab collaboration with Alex Chesler, et cetera, have come from the observations of what else these individuals experience. And so, it's been a great kind of collaboration communication between mechanistic animal model studies and the clinic. And so, one of the things that these individuals don't sense in addition to touch, is something called tactile allodynia, which is simply when touch becomes painful. You and I experienced this after small injury or sunburn where just touching your shoulder becomes painful, but for peripheral neuropathy and other neuropathic pain conditions, this is one of the major complaints that individuals have. And we know from the NIH studies that these individuals don't have this tactile allodynia. So touch becomes painful and doesn't apply to them, which tells us that if we block PIEZO2, we can actually get interesting relief from various aspects relative to neuropathic pain on other pain related neuropathies. But given everything we talked about, Eric, about how this is important for touch and proprioception, you don't want to make a pill that blocks PIEZO2 and you take it because this will have some serious on target side effects. But we are developing new compounds that block PIEZO2 and hope that it might be useful, at least as a topical medication pain and other indications. And we're actively working on this, as I said.Eric Topol (23:15):Yeah, I mean the topical one sounds like a winner because of peripheral neuropathy, but also I wonder if you could somehow target it to sick cells rather than if giving it in a systemic targeted way. I mean it has tremendous potential because we are on a serious hunt for much better relief of pain than exists today.Ardem Patapoutian (23:41):Absolutely.Eric Topol (23:42):Yeah. So that's exciting. I mean, that's another potential outgrowth of all this. Just going back, I mean the one that prompted me in November to write that about the human physiology in PIEZO, it was about intestinal stem cell fate decision and maintenance. I mean, it's just everywhere. But the work you've done certainly now has spurred on so many other groups to go after these different and many unanticipated functions. Were there any ones, of course, you've been pretty systematically addressing these that actually surprised you? You said, oh, are you kidding me when you read this? I never would've guessed this, or pretty much they followed suit as things were moving along.Ardem Patapoutian (24:33):So one of them is this role in macrophages that I found fascinating that we found a few years ago. So again, this came from human studies where PIEZO1 gain-of-function mutations. So in relation to loss of function, their gain-of-function where there's more activity given a certain amount of pressure. They have dehydrated red blood cells, which I'm not going to talk about right now. But they also have shown that in these patients, individuals, it's not really that pathological. They also have age-onset iron overload. What does that have to do with pressure sensing? And we brought that information into animal models, and we found that macrophages, their rate of phagocytosis depends on PIEZO, so that if you have too little PIEZO, they don't phagocytosis as much. If you have too much PIEZO, the phagocytosis too much. And this increased rate of phagocytosis in the long term because it's constantly eating red blood cells and the iron is circulating more causes long-term effects in iron overload. And again, as you kind of set that up, who would've thought that mechanical sensation is important for this basic hematology type?Eric Topol (25:52):Yeah, I mean, because we've been talking about the macro things, and here it is at the cellular level. I mean, it's just wild.Ardem Patapoutian (25:59):If you go back and look at a video of a macrophage eating up red blood cells, then you go, oh, I see how this has to do with pressure sensing because it is like extending little arms, feeling things letting go, going somewhere else. So again, I want to bring it back by this simple cell biological function of a cell type, like macrophage, exploring its environment is not just chemical, but very mechanical as well. And so, in retrospect, it is maybe not that surprising, that pressure sensing is important for its physiology.Career Changing?Eric Topol (26:33):Yeah, that's extraordinary. Well, that gets me to how your life has changed since 2021, because obviously this a big effect, big impact sort of thing. And I know that you're the first Armenian, first person from Lebanon to get this recognition. You recognized by the Lebanese Order of Merit. There's even a stamp of you, your picture characterized in 2022.Eric Topol (27:04):So if you were to sum up how it's changed because I see no change in you. You're the same person that has a great sense of humor. Often the tries to humor relaxed, calming. You haven't changed any to me, but how has it affected you?Ardem Patapoutian (27:26):Thank you, Eric. That's very kind of you. I try very hard for it not to change me. I do get a little bit more attention, a ton more invites, which unfortunately I have to say no to a lot of them because, and I'm sure you're very familiar with that concept and a lot of things are offered to you that I feel like it's so tempting to say yes because they're wonderful opportunities and an honor to be asked. But the end of the day, I'm trying to be very disciplined and not taking things on that I can do as an opportunity. But things that I really want to do. I think that's so hard to do sometimes is to separate those two. Why am I doing this? Is this really important for the goals that I have? So in one way, the answer for that is that I just want to stay in the lab and do my research with my students and postdoc, which is what I enjoy the most. But on the other hand, as you said, being the first Armenian who's received this, literally after the Nobel, I got this whole elementary school, all Armenian kids write to me multiple letters.Ardem Patapoutian (28:39):And they said, you look like me. I didn't think I could do this, but maybe I can. So in a sense, to ignore that and say, no, I just want to do my science, I don't want to be involved in any of that is also wrong. So I'm trying to balance being engaged in science outreach and helping to make science understood by the general public, realize that we're just regular people and at the same time how awesome science is. I love science and I like to project that, but leave plenty of time for me to just be a scientist and be in my lab and interact with my colleagues at Scripps, including you.Immigrant ScientistsEric Topol (29:21):Well, we're so lucky to have that chance. And I do want to mention, because you're prototyping in this regard about great immigrant scientists and other domains of course, but every year the Carnegie Foundation names these great immigrants and one year you were of course recognized. And in recent years, there have been more difficulties in people wanting to come to the US to get into science, and they wind up going to other places. It seems like that's a big loss for us. I mean, what if we weren't able to have had you come and so many hundreds, thousands of others that have contributed to this life science community? Maybe you could comment about that.Ardem Patapoutian (30:10):Yeah, I think it is tragic, as you say. I think in some circles, immigrants have this negative image or idea of what they bring, but at every level, immigrants have contributed so much to this country. It's a country of immigrants, of course, to start with. And I think it is important to put up a positive image of immigration and science is the ultimate example of that, right? I mean, I think when you go into any laboratory, you probably find if there's a lab of 16 people, you probably find people from 10 different countries. And we all work together. And the idea of also immigrant and especially about science is that I'm a big believer of changing field, changing things because just like that, immigrants have changed their whole life. So they come to a new culture, they bring with them their own way of thinking and their way of seeing things. And then you come into a new environment, and you see it a little bit differently. So that kind of change, whether it's because of physical immigration or immigrating from one field to another in science is really beneficial for science and society. And I think positive examples of this are an important part of highlighting this.Eric Topol (31:40):I couldn't agree with you more really.Bluesky vs Twitter/XEric Topol (31:41):Now, speaking of migration, there's been recently a big migration out of X, formerly Twitter to Bluesky, which I like the metaphor you liken to the Serengeti. Can you tell us about, now I know you're posting on Bluesky and of course so many others that you and I are mutual contacts, and our different networks are. What do you think about this migration outside of what was the platform where a lot of this, we shared things on X or before Musk took over known as Twitter? Thoughts about Bluesky?Ardem Patapoutian (32:27):Yeah, I think I use social media for a few reasons. The number one reason should be is to see new science by colleagues. My main point is that, but also, again, having fun in science is a big part of my draw to this. And as you can see from my posts, it's a bit lighthearted, and that's really me.Eric Topol (32:52):Right. Yeah.Ardem Patapoutian (32:52):I think on Twitter, things start getting a little bit dark and too many negative comments, and it was just not productive. And I just felt like after the elections, I felt like it was time to migrate. And I find Bluesky a great scientific community, and it's remarkable how quickly people have migrated from Twitter to Bluesky. But the counter argument for this is that you should stay in a place where majority of people are, because being in a bubble surrounding yourself by people like you doesn't help society. And so, I get that perspective as well. It just depends on what you're using the platform for and it's a difficult issue. But yeah, I've taken a break probably long-term break from Twitter. I'm on Bluesky now.Eric Topol (33:48):Yeah, no, the point you're bringing up about the echo chamber and is there going to be one for people that are leaning one way and they're thinking, and another with a whole different, often politically charged and even extreme views? It's really unfortunate if it does wind up that way. But right now, it seems like that migration is ongoing and it's substantial. And I guess we'll see how it settles out. I share your concern, and so far, I've been trying to keep a foot in both areas because I think if we all were to leave, then we're just kind of caving into a, it's tricky though. It really is because the noxious toxic type of comments, even when you try to avoid comments, you say, only followers can make a comment, they'll of course, quote your thing and then try to ding you and whatever. It's just crazy stuff, really.Ardem Patapoutian (34:53):I mean, what I think is that, that's why I said depends on why. I mean, your presence on social media is such an important part of science education. And I could almost say you can't afford to do what I do, which is I'm just putting my goofy posts and having fun. So we have different purposes in a way, and yeah, that affects what you use and how you use it.Eric Topol (35:17):Yeah, no, it's tricky it really is. We covered a lot of ground. Is there anything I missed that you want to get out there? Any part of this, your story and the PIEZO story, science and everything else that I didn't bring up?The Essentiality of Basic ScienceArdem Patapoutian (35:42):I just think that the basic science community is really suffering from decreasing amounts of funding and appreciation of doing basic science. And one of my goals, in addition to this immigrant scientist thing, is to remind people that all medicines start with basic science work. And funding this has mainly been through NIH and it's getting harder and harder for basic scientists to secure funding and I'm really worried about this. And we need to find ways to be okay for people to do basic science. And I'll give you one example. Whenever we make a publication and there's a journalist talking to us or some kind of press coverage, they ask, how is this directly affecting patients? And my work actually is very much related to patients, and I answer that question, but I also say, but it's also important to do science for the science sake because you don't know where the applications are going to come from. And we need to, as a society, encourage and fund and support basic science as the seeds of all these translational work. And I think doing that just kind of highlights that this is important too. We should support it, not just things that right now seem very related to translational that directly helps patients.Eric Topol (37:16):Well, I'm so glad you emphasized that because I mean, the PIEZO story is the exemplar. Look what's come of it, what might still come of it. In many respects here you are maybe 15 years into the story and there's still many parts of this that are untold, but if it wasn't for the basic science, we wouldn't have these remarkable and diverse insights. And recently you cited, and I think so many people read about the ‘crown jewel' NIH, front page New York Times, and how it's under threat because the new NIH director doesn't have a regard for basic science. He's actually, he's confirmed, which is likely, he's an economist, physician economist, never practiced medicine, but he doesn't really have a lot of regard for basic science. But as you point out, almost every drug that we have today came out of NIH basic work. And I mean, not just that, but all the disease insights and treatments and so much.Eric Topol (38:25):So this is really unfortunate if we have not just an NIH and other supporting foundations that don't see the priority, the fundamental aspect of basic science to then lead to, as we call translational, and then ultimately the way to promote human health, which is I think what we're all very much focused on ultimately. But you can't do it without getting to first base, and that's what you have done. You served it up and it's a great example. Well, Ardem, it's always a pleasure. This is a first time talking through a podcast. I hope we'll have many, many visits informally that will complement the ones we've already had, and we will follow the PIEZO work. Obviously, you have had just an exceptional impact, but you're still young and who knows what's next, right? I mean, look what happened to Barry Sharpless. He won here. He won two Nobel prizes, so you never know where things are headed.Ardem Patapoutian (39:36):Thank you, Eric, and I really appreciate what you do for the biomedical community. I think it's wonderful through your social media and this podcast, we all appreciate it.***********************************************************************************Please take a moment to complete the poll above.Thank you for reading, listening and subscribing to Ground Truths.If you found this informative please share it!All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and of course appreciated. All proceeds from them go to support Scripps Research. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. I welcome all comments from paid subscribers and will do my best to respond to each of them and any questions.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research.And Happy New Year! Get full access to Ground Truths at erictopol.substack.com/subscribe

The Nobel Prize winner talks about PIEZO 1 and 2, proprioception and the viral photo of him and his son from the 2021 Nobel Prize announcement.

The Nobel Prize winner talks about PIEZO 1 and 2, proprioception and the viral photo of him and his son from the 2021 Nobel Prize announcement.

This 15th episode of The Pain Beat is the third and final of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, part one of this series here, and part two of this series here). In this episode, The Pain Beat spoke with a group of collaborators and former mentees to discuss what the discoveries mean for the somatosensory field, as well as stories and insights about what it was like working with Drs. Julius and Patapoutian during that time. Podcast participants include: Allan Basbaum, PhD, FRS, University of California, San Francisco, USA Diana Bautista, PhD, University of California, Berkeley, USA Alexander Chesler, PhD, National Institutes of Health, Maryland, USA Ellen Lumpkin, PhD, University of California, Berkeley, USA Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

This 15th episode of The Pain Beat is the third and final of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, part one of this series here, and part two of this series here). In this episode, The Pain Beat spoke with a group of collaborators and former mentees to discuss what the discoveries mean for the somatosensory field, as well as stories and insights about what it was like working with Drs. Julius and Patapoutian during that time. Podcast participants include: Allan Basbaum, PhD, FRS, University of California, San Francisco, USA Diana Bautista, PhD, University of California, Berkeley, USA Alexander Chesler, PhD, National Institutes of Health, Maryland, USA Ellen Lumpkin, PhD, University of California, Berkeley, USA Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

This 14th episode of The Pain Beat is the second of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, and part one of this series here). In this episode, The Pain Beat spoke with Nobel Prize laureate Ardem Patapoutian and Bertrand Coste, Aix-Marseille University, France, to discuss their discovery of mechanically sensitive ion channels – Piezo1 and Piezo2. Podcast participants include: Ardem Patapoutian, PhD, Scripps Research, California, USA Bertrand Coste, PhD, Aix-Marseille University, France Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

This 14th episode of The Pain Beat is the second of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, and part one of this series here). In this episode, The Pain Beat spoke with Nobel Prize laureate Ardem Patapoutian and Bertrand Coste, Aix-Marseille University, France, to discuss their discovery of mechanically sensitive ion channels – Piezo1 and Piezo2. Podcast participants include: Ardem Patapoutian, PhD, Scripps Research, California, USA Bertrand Coste, PhD, Aix-Marseille University, France Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

Piezo通道是介导人类触觉感知的重要蛋白, 它的发现者Ardem Patapoutian也因此被授予了2021年的诺贝尔生理学和医学奖（与David Julius分享）。这期我们请到了解析piezo2 蛋白结构的两位研究者周珩和王莉做客我们的播客。我们除了聊到课题的方法和结论，也聊到了他们两位在合作推进这个课题时的压力，挣扎，坚持和课题突破时的喜悦，希望他们的感悟能给每一位正在课题中挣扎的研究者安慰和勇气。下面是播客大纲，大家可以点击时间点跳转到想听的话题Part I 关于piezo2的课题和冷冻电镜04:15 piezo通道有很重要的生理和病理学意义10:46 王莉接手了一个好几个人尝试了又放弃了的课题。15:22 piezo2在蛋白纯化方面的重重困难20:27 科普冷冻电镜解析蛋白结构的原理简介，在piezo2课题中的应用以及遇到的困难29:04 周珩因为建模型累出了鼠标手，但是成就感满满。31:02 两个强迫症患者为课题共同付出了很多，彼此支持和鼓励。35:19 课题那么困难，王莉为什么一直相信它能做出来呢？40:15 王莉跟周珩在合作过程中充满了摩擦和争吵 （十分搞笑）56:27 结构生物学为什么总发顶刊，是不是在灌水？Part II 聊聊挫折和人生68:28 王莉聊了聊自己不太顺利的求学和科研之路，但是依然坚持75:32 学霸周珩是如何走上科研道路的，他们为什么爱科研80:42 王莉聊自己在科研过程中的suffer和struggle，这些都成了她的财富（必听）85:17 王莉和周珩为什么在人生不顺利的时候还能自信的勇往直前 （必听）95:03 漂亮的王莉为什么一直单身？100:20 趣事儿：周珩范了一个巨尴尬的错误，大家笑翻了105:37 给听友们的寄语精美的三叶桨结构的piezo2结构 (Wang et al., Nature, 2019)Piezo2 文章链接

This 13th episode of The Pain Beat is the first of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, and PRF related news story here). In this episode, The Pain Beat spoke with Nobel Prize laureate David Julius and Michael Caterina, Johns Hopkins University School of Medicine, Maryland, USA, to discuss their discovery of TRPV1. The conversation provides insight regarding their thought processes and problem solving, the enduring challenges of scientific discoveries, and the fun they had along the way. Podcast participants include: David Julius, PhD, University of California, San Francisco, USA Michael Caterina, MD, PhD, Johns Hopkins School of Medicine, Maryland, USA Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

This 13th episode of The Pain Beat is the first of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, and PRF related news story here). In this episode, The Pain Beat spoke with Nobel Prize laureate David Julius and Michael Caterina, Johns Hopkins University School of Medicine, Maryland, USA, to discuss their discovery of TRPV1. The conversation provides insight regarding their thought processes and problem solving, the enduring challenges of scientific discoveries, and the fun they had along the way. Podcast participants include: David Julius, PhD, University of California, San Francisco, USA Michael Caterina, MD, PhD, Johns Hopkins School of Medicine, Maryland, USA Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)

(NOTA: aunque este episodio se publica ahora, se grabó el 16 de octubre de 2021). Programa especial, con ocasión de la concesión del premio Nobel 2021 en Fisiología o Medicina. En la Tertulia, Pepe, Francis e Iker celebran una nueva edición de estos célebres premios y comentan el galardón recién concedido a David Julius y Ardem Patapoutian "por su descubrimiento de los receptores para temperatura y tacto". La profesora Teresa Giráldez (Universidad de la Laguna), experta en el estudio de los canales iónicos, tuvo la amabilidad de participar en la sección de Bionoticias para unirse a la celebración y compartir su valoración de este premio. Además de otras noticias de interés, presentadas por Iker en Bionoticias, el episodio incluye el comentario de Francis sobre dos artículos de los grupos de Feng Zhang (https://www.science.org/doi/10.1126/science.abj6856) y Virginijus Siksnys (https://www.nature.com/articles/s41586-021-04058-1) en los que demuestran que algunas transposasas tienen actividad ADN nucleasa guiada por ARN y que, por tanto, pueden ser utilizadas como herramientas de edición genética, similar a las más conocidas CRISPR-Cas, con algunas ventajas adicionales. Esperamos que os guste.

In 2021, Dr. David Julius and Dr. Ardem Patapoutian won the Nobel Prize in Physiology and Medicine for their discoveries related to temperature and touch receptors. In this episode, Dr. Rose Hill and Dr. Robert Bonin introduce us to this topic of  sensory perception, specifically touch and pain. Dr. Bonin describes how we experience pain, delving into acute vs chronic pain, thresholds to pain, and the distinction between nociception and pain. Dr. Hill also shares about her experience being in Dr. Patapoutian's Nobel winning lab, and her work on the perception of itch. Additionally, we get a deeper look into the inner workings of the Nobel Prize, as Dr. Abdel El Manira shares about his time on the Nobel Committee and the inner workings of the Nobel. Join us on this episode, as we unravel touch and the Nobel Prize.    Written by: Veena Sanmugananthan   Links Discoveries of receptors for temperature and touch Bonin Lab UofT Centre for the Study of Pain Dr. Hill profile A trio of ion channels takes the heat Profile of 2021 Nobel Prize winners

Ardem Patapoutian discovered more about our sense of touch than we ever knew and Emmanuelle Charpentier co-invented the most powerful biomedical tool we've ever had. Celebrating two past winners of the Kavli Prize a week before the 2022 laureates are announced.

2021 medicine laureate Ardem Patapoutian tells us about his shock and happiness after receiving the Nobel Prize, or as he puts it: “All of us in science know that the Nobel Prize is a big deal but I really didn't anticipate it to be this big of a deal.” Patapoutian also shares his life story immigrating to the US from war-wrecked Lebanon as a young boy. He speaks about his beautiful home country and its excellent food and warm people. In conversation with podcast host Adam Smith, they discuss Patapoutian's new life in the US and his university experience at UCLA. Patapoutian tells us that he quickly fell in love with the idea of doing science: “The best thing was not to see if the experiment worked, the best thing was to come up with the experiment itself.” He also shares a strong and valuable message: “We all take things for granted, whether it is our jobs, our schools, our parents, our family and the best thing to not take anything for granted is to let go off it a little and then you realise how much something means to you.” See acast.com/privacy for privacy and opt-out information.

Existen receptores celulares llamados Piezos que le permiten al cuerpo reconocer donde se encuentran el resto de sus miembros. También nos permiten sentir el apapacho de la persona querida. Nos cuenta Christopher Cedillo @chrisantics Temporada 4 *** Fuentes: Entrevista con Ardem Patapoutian. En: https://www.youtube.com/watch?v=Eslj3T_opA8&ab_channel=Fundaci%C3%B3nBBVA Our amazing sense of touch, explained by a Nobel laureate. En: https://www.vox.com/science-and-health/22710533/nobel-prize-2021-ardem-patapoutian-touch Texto inicial de Eduardo Galeano, de su libro “Las palabras andantes” *** En este episodio, ""El cuerpo sabe"". El guion y la voz fueron de Christopher Cedillo, la producción de audio fue de Ales y la ilustración de la portada por Andrea y Yoreli Sánchez. Este podcast es una producción original de MotusLab. Agradecimientos a Valeria Caltzontzin, Pedro Lobato, Karla González y Raúl Romero quienes revisaron y comentaron el guion. *** ¡Sigue estas redes! Divulgación de la ciencia y a veces cosas de arte: https://www.instagram.com/colectivomotus El de la voz y guion de este episodio: https://www.instagram.com/chrisantics De quién creó la ilustración/portada de este episodio: https://www.instagram.com/garabatosalazar" https://blog.motuslab.xyz/ colectivomotus@gmail.com

My friend Jill drops by to kick off the new year and a new season of BodyTalk! Listen in as we talk about the highlights from the last year in fascia science. And a lot happened. Here are all the links. 1) Extracellular Matrix in 3D Color 2) Delphi Study on Foam Rolling 3) Massage doesn't just make muscles feel better, it makes them heal faster and stronger 4) Interview with researcher Bo Ri Seo 5) NIH HEAL Initiative 6) Scripps Research neuroscientist Ardem Patapoutian receives 2021 Nobel Prize in Physiology 7) 2021 Medicine Nobel Prize Winner Explains the Importance of Sensing Touch 8) International Consortium on Manual Therapies 9) Gather Town 10) Fascia, Function, and Medical Applications 11) 2022 Fascia Research Congress 12) FR:EIA BodyWorlds Exhibit 13) David's Class in Amsterdam – David Lesondak: Resolving Low Back Pain, Neck, and Shoulder Pain in Our Digital Age 14) Jill's Class with Tom Myers – Rolling Along the Anatomy Trains: New Routes Live Online with Jill Miller and Tom Myers --- Send in a voice message: https://anchor.fm/david-lesondak/message

Two California scientists, David Julius from UCSF and Ardem Patapoutian from San Diego's Scripps Research, have won the 2021 Nobel Prize for medicine. In their work, which focuses on the biology of our senses, Julius and Patapoutian identified receptors that allow the cells in your body to sense touch and temperature. Their findings hold potential medical applications for better treatment of chronic pain. We talk with the prize-winning researchers about their work.

This special live episode features a conversation with Klaus Hasselmann, the 2021 physics laureate. Before that we will also present some highlights from this year's announcement telephone interviews. Hear Klaus Hasselmann alongside his fellow 2021 laureates David Julius, Benjamin List, David MacMillan and Ardem Patapoutian – and relive some of the moments of disbelief, shock and excitement from the calls.From the stage of Nobel Week Dialogue in Gothenburg Sweden, podcast producer Karin Svensson reprises her guest role as host of the show, asking Adam Smith about the new crop of 2021 telephone interviews. Then, Nobel Prize Outreach's Adam Smith takes the helm for a conversation with Klaus Hasselmann. Klaus Hasselmann received the Nobel Prize in physics for developing climate models to reliably predict global warming. He shares the prize with Syukuro Manabe and Giorgio Parisi. He is a professor emeritus of the University of Hamburg and a former director of the Max Planck institute for meteorology. See acast.com/privacy for privacy and opt-out information.

Ardem Patapoutian växte upp i Beirut och var bara åtta år när inbördeskriget började. När han var 18 blev han kidnappad av milismän. Den uppväxten påverkade mig mycket, men jag tror jag då lärde mig sådant som jag senare haft nytta av, säger han. Han syftar på sådant som ihärdighet och tuffhet, som behövs för att ta sig fram som forskare. Han får priset för upptäckten av receptorer, en sorts mottagarmolekyler, som känner av tryck och beröring, allt från en kram, smekning, eller kyss och sanden under barfotafötter till sånt som gör ont. Lena Nordlund lena.nordlund@sverigesradio.se

El dolor es una emoción que tu cuerpo crea para evitar cosas que son nocivas para ti … el dolor es muy útil … necesitamos el dolor para sobrevivir”. Ardem Patapoutian, Premio Nobel 2021. ...

Ce dimanche, Mac Lesggy nous livre les dernières découvertes des Prix Nobel de médecine, David Julius et Ardem Patapoutian. C'est aussi grâce à des recherches sur la sensation de brûlure déclenchée par le piment que ces découvertes ont pu être réalisées. Les travaux de ces chercheurs ont permis de révéler comment notre corps percevait des informations essentielles de notre environnement : la chaleur, le froid ou encore la pression. Mais surtout, comment les capteurs informent notre cerveau en une fraction de seconde.

Guest: Professor David Julius John is joined by Professor David Julius. Alongside fellow scientist, Ardem Patapoutian, he has been honoured by the 2021 Nobel Prize for Medicine for discoveries in heat and touch.  Their work has helped show how humans convert the physical impact from heat or touch into nerve impulses that allow us to 'perceive and adapt to the world around us'.  A biochemist and molecular biologist, Julius's work has focused on how our bodies sense heat, cold, and chemical irritants, leading to new insights about the fundamental nature of pain and new targets for pain therapy. See omnystudio.com/listener for privacy information.

(3:21) A astrofísica galega Olga Suárez traballa no observatorio astronómico de Niza en Francia. Este verán impartiu unha charla na Domus en A Coruña sobre mulleres astrónomas. Conversamos con ela e co noso estreleiro Martin Pawley. (17:37) Debullamos o premio nobel de medicina ou fisioloxía con Félix Viana, investigador do Instituto de Nuerociencia de Alacante. Viana traballa nos receptores de presión e temperatura, e por iso coñece persoalmente aos galardoados David Julius e Ardem Patapoutian. Cando Patapoutian chegou emigrado a Estados Unidos desde o Líbano tivo que sobrevir facendo horóscopos en Armenio. (45:35) Lembramos a Paco Franco, director do Aquarium Finisterrae, tristemente finado da man do director dos Museos Científicos Coruñeses Marcos Pérez. www.efefvesciencia.org

The Nobel Prize, instituted in 1901, was initially awarded in five categories – Physics, Chemistry, Physiology or Medicine, Literature and Peace.  A sixth award, the Nobel Prize in Economic Sciences was instituted in 1968 by the Royal Bank of Sweden and first awarded in 1969.  The Nobel Prize is named after Swedish inventor and industrialist Alfred Nobel, and is awarded annually from a fund that Nobel set aside in his 1895 will for this purpose.  This year's Nobel Prize was unique. We had the first Nobel for climate scientists.  The Nobel Prize in Physics this year went to Syukuru Manabe, a Japanese-American meteorologist and climatologist, for his pioneering work on understanding climate change.  In 1967, Manabe and Richard Wetherland wrote a research paper describing the impact of carbon dioxide and water vapour on global warming. Manabe, now at Princeton University, shared one half of the prize with Klaus Hasselmann, another climate scientist. Hasselmann, 89, from the Max Planck Institute for Meteorology in Hamburg, Germany, used Manabe's work and created computer models that managed to link weather and climate. Hasselmann's work helped scientists identify whether a certain phenomenon was caused by natural forces or human activity The other half of the Physics Nobel went to Georgio Parisi for his contributions in advancing the understanding of complex systems Complex systems have a very high degree of randomness, like weather and climate phenomena The Physics Nobel for climate scientists is perhaps a greater indication of how fraught our future is by the perils of global warming.  Before this, the Intergovernmental Panel on Climate Change (IPCC) had won the Peace Nobel in 2007, for its role in creating awareness about the fight against climate change.  The Nobel Prize for chemistry this time has been awarded to Benjamin List and David WC MacMillan. The Nobel panel said List and MacMillan in 2000 independently developed a new way of catalysis. A catalyst is a substance that increases the rate of a chemical reaction without taking part in the reaction, or without undergoing any changes during the chemical reaction. The Nobel Prize for Physiology and Medicine has been awarded to American scientists David Julius and Ardem Patapoutian.  They've understood the mechanism through which our body perceives temperature and pressure.  The award-giving body said their discovery could pave the way for new pain-killers. The Nobel Peace Prize this year went to two journalists, from the Philippines and Russia, who have been running independent news organisations in their countries in authoritarian regimes where they face threats of detention and death.  Maria Ressa of the Philippines and Dmitry Muratov of Russia received the Prize “for their courageous fight for freedom of expression”. This year's Nobel Prize for Literature went to 72-year-old Tanzanian novelist Abdulrazak Gurnah, an author of 10 novels and several short stories. And, the Nobel Prize for Economic Sciences went to 3 US-based economists David Card, Joshua D Angrist and Guido W Imbens.  David Card is a Canadian labour economist and Professor of Economics at the University of California, Berkeley.  He has won the Nobel for his empirical contributions to labour economics.  Card has analysed the labour market effects of minimum wages, immigration and education. His work has challenged conventional wisdom. The results of his studies on restaurants in New Jersey and Eastern Pennsylvania have shown that increasing the minimum wage does not necessarily lead to fewer jobs.  "We now know that the incomes of people who were born in a country can benefit from new immigration, while people who immigrated at an earlier time risk being negatively affected. We have also realised that resources in schools are far more important for students' future labour market success than was previously thought," the Nobel

A probe to study the Trojan asteroids is expected to take off this week, but what will this mission uncover about the formation of the solar system? Also, we explore new technology to observe asteroids, as well as a mission to deflect an incoming celestial object. And, we hear from the Nobel co-laureate in Physiology or Medicine, Ardem Patapoutian, about temperature and pressure sensing. Alok Jha hosts. For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our new weekly science newsletter at economist.com/simplyscience.Terms and conditions for the book competition featured in this podcast are available at economist.com/podcast-contest. See acast.com/privacy for privacy and opt-out information.

A probe to study the Trojan asteroids is expected to take off this week, but what will this mission uncover about the formation of the solar system? Also, we explore new technology to observe asteroids, as well as a mission to deflect an incoming celestial object. And, we hear from the Nobel co-laureate in Physiology or Medicine, Ardem Patapoutian, about temperature and pressure sensing. Alok Jha hosts. For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our new weekly science newsletter at economist.com/simplyscience.Terms and conditions for the book competition featured in this podcast are available at economist.com/podcast-contest. See acast.com/privacy for privacy and opt-out information.

A lot of science has happened this week you guys, and I'm going to unpack it for you. Here are the important links Scripps Research neuroscientist Ardem Patapoutian receives 2021 Nobel Prize in Physiology 2021 Medicine Nobel Prize Winner Explains the Importance of Sensing Touch Massage doesn't just make muscles feel better, it makes them heal faster and stronger The POD – www.discoverthepod.com Support BodyTalk https://www.patreon.com/bodytalkradio --- Send in a voice message: https://anchor.fm/david-lesondak/message

Una settimana fa gli scienziati americani David Julius e Ardem Patapoutian hanno vinto il Premio Nobel per la Medicina 2021. La motivazione è collegata alle loro scoperte sui "recettori per la temperatura e il tatto", utilizzate per mettere a punto cure per numerose patologie, tra cui, il dolore cronico. Approfondiamo il tema a Obiettivo Salute risveglio con il prof. Antonio Malgaroli, Ordinario di Fisiologia Umana all'Università San Raffaele di Milano In chiusura parte da oggi un incontro dedicato ai genitori con lo psicoterapeuta Alberto Pellai autore con Barbara Tamborini di "Vietato ai minori di 14 anni" (De Agostini). Con l'esperto affronteremo 5 situazioni particolarmente sfidanti per le mamme e i papà di figli sotto i 14 anni

Esta semana se han fallado los Premios Nobel, y en Más de Uno organizamos una tertulia especial para comentar las tres categorías de ciencias. En Fisiología o Medicina se ha premiado a David Julius y Ardem Patapoutian por el descubrimiento y caracterización de los receptores de la temperatura y el tacto. Estos receptores son pequeñas máquinas situadas en las membranas de algunas neuronas que permiten que la neurona "sepa" si se la está sometiendo a presión, o cuál es la temperatura exterior. En Física se ha premiado a Syukuro Manabe y Klaus Hasselmann, por sus contribuciones a los modelos del clima que son fundamentales para entender el cambio climático, y a Giorgio Parisi, por desarrollar una técnica para "encontrar el orden" en un sistema desordenado. Finalmente, en Química el premio ha sido para Benjamin List y David MacMillan por desarrollar los primeros catalizadores orgánicos asimétricos. Estas sustancias permiten "guiar" las reacciones químicas hacia las moléculas que más nos interesan, y son capaces de distinguir entre las diversas geometrías que la molécula final puede tener. Para contaros todo esto hemos organizado una tertulia de científicos, con Ignacio Crespo, médico y director de la sección de ciencia del diario La Razón, y Francis Villatoro, físico, matemático y creador del blog La Ciencia de la Mula Francis. Como siempre, además del tema central tenemos también el reto matemático de Santi García Cremades, que esta vez nos habla de la Conjetura de Goldbach: el hecho de que todo número par (mayor que 2) parece poder escribirse como la suma de dos números primos. Santi nos anima a comprobar la conjetura con tres ejemplos entre el 3 y el 100. Este programa se emitió originalmente el 7 de octubre de 2021. Podéis escuchar el resto de audios de Más de Uno en la app de Onda Cero y en su web, ondacero.es

In EVN Report's news roundup for the week of October 8: Azerbaijan's national air carrier operates its first flight through Armenian airspace since 2014; newly released Pandora Papers implicate former and current Armenian officials; Armenian-American molecular biologist Ardem Patapoutian is awarded the Nobel Prize in Physiology or Medicine and more.

In EVN Report's news roundup for the week of October 8: Azerbaijan's national air carrier operates its first flight through Armenian airspace since 2014; newly released Pandora Papers implicate former and current Armenian officials; Armenian-American molecular biologist Ardem Patapoutian is awarded the Nobel Prize in Physiology or Medicine and more.

Bulunduğumuz haftanın bilim dünyasından önemli gelişmeleri sizler için derledik. The Nobel Assembly at Karolinska Institutet has today decided to award the 2021 Nobel Prize in Physiology or Medicine jointly to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch. https://www.nobelprize.org/prizes/medicine/2021/press-release Tracing the origin of hair follicle stem cells. https://doi.org/10.1038/s41586-021-03638-5 A reflective gray material can lower road surface temperatures. https://www.scientificamerican.com/article/to-beat-the-heat-phoenix-paints-its-streets-gray Type I interferon response and vascular alteration in chilblain like lesions during the COVID-19 outbreak. https://doi.org/10.1111/bjd.20707 Bize 101.podcast.info@gmail.com adresinden ulaşabilirsiniz.

Our ability to sense heat, cold and touch is essential for survival and underpins our interaction with the world around us. In our daily lives we take these sensations for granted, but how are nerve impulses initiated so that temperature and pressure can be perceived? This question has been solved by this year's Nobel Prize laureates. David Julius utilized capsaicin, a pungent compound from chili peppers that induces a burning sensation, to identify a sensor in the nerve endings of the skin that responds to heat. Ardem Patapoutian used pressure-sensitive cells to discover a novel class of sensors that respond to mechanical stimuli in the skin and internal organs. These breakthrough discoveries launched intense research activities leading to a rapid increase in our understanding of how our nervous system senses heat, cold, and mechanical stimuli. The laureates identified critical missing links in our understanding of the complex interplay between our senses and the environment.

In EVN Report's news roundup for the week of October 8: Azerbaijan's national air carrier operates its first flight through Armenian airspace since 2014; newly released Pandora Papers implicate former and current Armenian officials; Armenian-American molecular biologist Ardem Patapoutian is awarded the Nobel Prize in Physiology or Medicine and more. The post Ep. 158: The Week in Review (08.10.21) appeared first on EVN Report.

Los seres vivos estamos muy bien equipados para captar información del entorno: tenemos ojos, que nos permiten capturar la luz, oídos, que nos permiten capturar las ondas de presión que viajan por el aire o el agua... y tenemos también otros sentidos, más sutiles pero igual de fundamentales. El gusto y el olfato emergen de los sensores químicos de nuestros antepasados, que les permitían identificar sustancias químicas beneficiosas o nocivas en el entorno. Y el tacto emerge de sus sensores mecánicos y físicos: todo ser vivo, incluso los unicelulares, necesitan saber cuál es la temperatura en el exterior, o si están siendo aplastados por una roca. Para obtener esa información desarrollaron una serie de máquinas moleculares que estaban colocadas en la membrana de sus células, y que "avisaban" a la célula si el calor era excesivo o si la presión era demasiado alta. Evolución mediante, estos sensores están ahora dispersos por nuestro cuerpo, tanto en el interior como en el exterior, y dan lugar a este carrusel de sensaciones al que nos referimos a través de varias palabras. "Tacto", "dolor" y "propiocepción" (o la percepción de nuestra postura corporal y estado de movimiento). Este año el Premio Nobel de Fisiología o Medicina ha galardonado la investigación en los receptores de la temperatura y la presión, llevada a cabo por los laboratorios de David Julius y Ardem Patapoutian. En el capítulo de hoy os hablamos de cómo funcionan esos receptores y podremos oír las voces de los dos premiados. Si os interesa este tema volved un poquito atrás, porque se dio la cósmica casualidad de que en el episodio s11e04 entrevistamos a David Julius y hablamos sobre los receptores de la temperatura, y cómo se ven afectados por algunas sustancias, como las que se encuentran en las guindillas, que los hacen más sensibles. Este programa se emitió originalmente el 4 de octubre de 2021. Podéis escuchar el resto de audios de La Brújula en la app de Onda Cero y en su web, ondacero.es

Two California scientists, David Julius from UCSF and Ardem Patapoutian from San Diego's Scripps Research, have won the 2021 Nobel Prize for medicine. In their work, which focuses on the biology of our senses, Julius and Patapoutian identified receptors that allow the cells in your body to sense touch and temperature. Their findings hold potential medical applications for better treatment of chronic pain. We talk with the prize-winning researchers about their work.

O governo de São Paulo anunciou que vai fechar todas as bilheterias do Metrô e da CPTM até o fim deste ano. Além de explicar o porquê da medida, o monitor Caio Mello (do curso de Jornalismo) conta de que forma será feita a compra do bilhete no estado e o destino dos funcionários do setor em questão. Conheça as descobertas de David Julius e Ardem Patapoutian, vencedores do Prêmio Nobel 2021 em Medicina.

El presidente López Obrador anunció que se retomarán los eventos masivos a partir del próximo mes./ Los gobernadores de Nuevo León y Jalisco presentarán una propuesta para realizar cambios al Pacto Fiscal con el fin de buscar más recursos para los estados./ Facebook y sus plataformas: Messenger, Instagram y WhatsApp sufrieron este lunes una masiva interrupción en su servicio, que afectó a decenas de millones de usuarios./David Julius y Ardem Patapoutian, ganan el Premio Nobel de Medicina. Hoy se anuncia el Nobel de Física./ El derrame de crudo de una plataforma del Pacífico ha provocado el cierre de varias playas y la prohibición de la actividad pesquera en el sur de California.

Much of San Diego experienced hours of thunder, lightning and pouring rain, less than 24 hours after a mild Santa Ana. Another rainstorm may be on its way at the end of the week. Plus, the oil spill in Orange County could have an environmental impact for years. Also, San Diego Nobel Prize-winner Ardem Patapoutian talks about the journey that brought him to the U.S. and a career in science. In addition, how will the new sweeping laws on policing affect law enforcement and the people they serve? Meanwhile, as parts of the United States, such as Texas, are restricting access to abortion, in Mexico, things seem to be headed in the other direction. And, while the military has become more racially diverse, a recent survey found Black, Latino, and Asian service members don't always feel welcome off-base. Finally, the Haunted Hotel reopens to scare people in person after being closed last year because of the pandemic. Owner Greg DeFatta speaks to KPBS Arts Reporter Beth Accomando about what to expect.

Vad fan hände egentligen igår när internet DOG? Adele ska ÄNTLIGEN släppa ny musik, Charlie XCX har släppt en het musikvideo som utspelar sig på en begravning, Daniela Rathana glider in i studion och förklarar vad farstaglitter är. Expressens kulturchef Karin Olsson gästar oss och går igenom reaktionerna efter Lars Vilks död. Succéfilmskaparen Ninja Thyberg har gjort filmen Pleasure om porrindustrin, i huvudrollen glänser Sofia Kappel och vi pratar med Ninja om hennes resor till LA och om hennes syn på porr har ändrats. Nobelpriset i medicin har INTE "vunnits" utan tilldelats David Julius och Ardem Patapoutian för sina upptäckter av receptorer för temperatur och beröring, Kalle Berg från P3 Nyheter förklarar för oss. Programledare: Kodjo Akolor, David Druid och Vendela Lundberg

US-based scientists, David Julius and Ardem Patapoutian were awarded the Nobel Prize in Physiology or Medicine. Learn more about your ad choices. Visit megaphone.fm/adchoices

Le prix Nobel 2021 de médecine et de physiologie a été décerné à David Julius et Ardem Patapoutian pour leurs découvertes sur la façon dont le système nerveux ressent la température et le toucher. Il s'agit d'avancées révolutionnaires pour comprendre les mécanismes de la douleur, selon les membres du jury Nobel à Stockholm. L'éclairage d'Isabelle Decosterd, directrice du Centre d'antalgie du Centre hospitalier universitaire vaudois (CHUV) et de l'Université de Lausanne (Unil), interrogée par Sarah Dirren.

El Dr. José Ramón Eguibar, director general de investigación, explica en qué consistió la investigación desarrollada durante décadas por los ganadores del Premio Nobel de fisiología y medicina 2021, los científicos David Julius y Ardem Patapoutian. Dicho proyecto se relaciona con el descubrimiento del mecanismo de funcionamiento de ciertos canales celulares que cubren el papel de receptores de temperatura y de tacto del cuerpo. Ellos se apoyaron en técnicas de biología molecular y todo surgió a partir de las sensaciones generadas por la molécula capsaicina del chile.

Wie spüren wir, dass etwas heiß ist oder wie stark jemand uns berührt? Die beiden Wissenschaftler David Julius und Ardem Patapoutian haben herausgefunden, wie äußere Reize von unseren Nerven umgewandelt werden – das war jahrhundertelang ein Rätsel. Sie haben die Rezeptoren für Hitze und Kälte entdeckt und jetzt für ihre Grundlagenforschung den Nobelpreis bekommen. Jochen Steiner im Gespräch mit SWR-Medizinredakteurin Ulrike Till.

Hola polizones, directos de los Nobel: Lunes 4, martes 5 y miércoles 6 de octubre de 2021 a las 11.30 am en twitch.tv/laurafloresciencia Esta semana haremos 3 programas informándoos sobre los laureados de este año. Esperamos que os guste. Nos vemos en el Beagle. Dónde encontrarnos: email: elcamarotededarwin@gmail.com Twitch: www.twitch.tv/laurafloresciencia Nuestra web: https://linktr.ee/camarotedarwin TikTok: https://www.tiktok.com/@lauraflores.ciencia Ig: https://www.instagram.com/lauraflores.ciencia/ Twitter: https://twitter.com/CamaroteDarwin

- Đến hẹn lại lên, mùa Nobel 2021 đã chính thức bắt đầu, với giải thưởng đầu tiên- Giải Nobel Y sinh được trao cho 2 hai nhà sinh học người Mỹ David Julius và Ardem Patapoutian để tôn vinh những phát hiện của họ về cơ chế thụ cảm nhiệt độ và xúc giác. Cũng giống như năm ngoái, đại dịch COVID-19 khiến lễ trao giải thưởng Nobel theo truyền thống phải điều chỉnh hình thức tổ chức trong hai năm liên tiếp. Tác giả : Thu Hoài/VOV1 Chủ đề : giải nobel, y sinh, cảm ứng --- Support this podcast: https://anchor.fm/vov1thegioi/support

Upptäckten av hur kroppen registrerar och tolkar temperatur- och känselintryck får Nobelpriset i fysiologi eller medicin år 2021. Vetenskapsradions medicinreporter Annika Östman och Katarina Sundberg är på plats på Karolinska Institutet i Solna och rapporterar om årets Nobelpris i fysiologi och medicin som tilldelades de två amerikanerna David Julius och Ardem Patapoutian. Vi hör Patrik Ernfors, professor i vävnadsbiologi vid Karolinska institutet och medlem i Karolinska Institutets Nobelkommitté. Programledare: Annika Östman  annika.ostman@sverigesradio.se Programledare: Katarina Sundberg katarina.sundberg@sverigesradio.se Producent: Camilla Widebeck camilla.widebeck@sverigesradio.se

durée : 00:25:15 - Journal de 12h30 - Leurs "découvertes révolutionnaires" ont "permis de comprendre comment la chaleur, le froid et la force mécanique peuvent initier les impulsions nerveuses qui nous permettent de percevoir et de nous adapter au monde". - invités : Delphine Héquet gynécologue-chirurgienne à l'Institut Curie

In our news wrap Monday, United Nations officials condemned Libya for a violent crackdown on migrants trying to sail to Europe. In the U.S., the Biden administration reversed a Trump-era ban on abortion referrals by family planning clinics that receive federal funding. Americans David Julius and Ardem Patapoutian won the 2021 Nobel Prize in medicine for discovering temperature and touch receptors. PBS NewsHour is supported by - https://www.pbs.org/newshour/about/funders

Der Nobelpreis für Medizin geht in diesem Jahr an David Julius und Ardem Patapoutian. Die Molekularbiologen haben die Rolle sogenannter Rezeptoren in unserem Nervensystem erforscht. Im Podcastupdate erklärt Jakob Simmank, der Leiter des ZEIT-ONLINE-Gesundheitsressorts, wo die Grundlagenforschung von Julius und Patapoutian künftig angewandt werden könnte. Außerdem im Update: Die Pandora Papers legen offen, wie Hunderte Amtsträger aus der ganzen Welt ihr Vermögen in Steueroasen versteckt haben. Die FDP zieht in den Sondierungsgesprächen eine rote Linie bei Steuererhöhungen und die SPD hat keinen Plan B neben einer Ampel-Koalition. Was noch? Tauende Permafrostböden legen Stoßzähne von Mammuts frei. Moderation und Produktion: Jannis Carmesin Mitarbeit: Alma Dewerny Fragen, Kritik, Anregungen? Sie erreichen uns unter wasjetzt@zeit.de. Weitere Links zur Folge: David Julius und Ardem Patapoutian : Medizinnobelpreis für die Entdeckung von Hautrezeptoren (https://www.zeit.de/gesundheit/2021-10/medizin-nobelpreis--david-julius-ardem-patapoutian-hautrezeptoren-entdeckung) Nobelpreise: Wer erhält 2021 die höchste Auszeichnung? (https://www.zeit.de/thema/nobelpreis) Pandora Papers: Steueroasen-Leak enthüllt heimliche Geschäfte Hunderter Politiker (https://www.zeit.de/politik/2021-10/pandora-papers-offshore-briefkastenfirmen-icij-steueroasen) Pandora Papers: Bundesregierung sieht bislang kaum Deutschlandbezug von Offshore-Leak (https://www.zeit.de/politik/deutschland/2021-10/pandora-papers-deutschland-bezug-bundesfinanzministerium-erstvermutung) Koalitionsbildung: SPD bereit für Dreier-Sondierung einer Ampel-Koalition (https://www.zeit.de/politik/deutschland/2021-09/bundestagswahl-news-spd-union-gruene-fdp-jamaika-ampel-koalitionsverhandlung-live) Was noch: Inside Russia's Woolly Mammoth Tusk Trade (https://www.youtube.com/watch?v=REgVkpWkh-o&t=93s)

Der Nobelpreis für Physiologie/Medizin 2021 geht an David Julius und Ardem Patapoutian für die Entdeckung von Rezeptoren für Temperatur und Druck. Diese Empfindungen sind für uns das alltäglichste und dennoch überlebenswichtig. Auf die Spur kam David Julius seiner Entdeckung mit Chili. www.deutschlandfunk.de, Forschung aktuell Hören bis: 19.01.2038 04:14 Direkter Link zur Audiodatei

"In science many times it's the things that we take for granted that are of high interest." – As Ardem Patapoutian says, sometimes the familiar can yield the best surprises. When it comes to figuring out how our senses work, the sense of touch "was kind of the big elephant in the room." Patapoutian had his phone on Do Not Disturb when Stockholm tried to call him but got the news, via his Dad, just in time to watch the press conference, sitting in bed with his son Luca. Adam Smith caught him there to record this brief call moments after the public announcement of his Nobel Prize in Physiology or Medicine, and he describes how finally finding the sensors that allow cells to detect pressure has opened up whole new unexpected vistas of phenomena that are governed by sensitivity to touch. As he reflects, "Nobody ever could have thought that pressure sensing is related to these processes."From October 4-11, don't miss our mini-season that will showcase the absolute freshest interviews with the new 2021 Nobel Prize laureates. See acast.com/privacy for privacy and opt-out information.

Nobelovu cenu za fyziologii a lékařství za rok 2021 dostanou společně dva američtí molekulární biologové David Julius a Ardem Patapoutian za objev receptorů teploty a hmatu. V čem je jejich výzkum unikátní? Na to se zeptáme v pořadu Věda Plus. Uslyšíte také, že experti brněnského Vysokého učení technického vytiskli betonové hřiště pro děti na pražských Hájích.

durée : 00:25:15 - Journal de 12h30 - Leurs "découvertes révolutionnaires" ont "permis de comprendre comment la chaleur, le froid et la force mécanique peuvent initier les impulsions nerveuses qui nous permettent de percevoir et de nous adapter au monde". - invités : Delphine Héquet gynécologue-chirurgienne à l'Institut Curie

Il Nobel 2021 per la Medicina e la fisiologia

The Pandora Papers, the largest ever leak of global financial data, have prompted mix reactions over the allegations they contain about a number of prominent world figures. Newshour looks into the potential consequences for two of them, the family of Kenyan President Uhuru Kenyatta, and Czech Prime Minister Andrej Babis. Also on the program: one of the winners of the Nobel prize for medicine, Ardem Patapoutian, tells us about his revolutionary findings on pain; and American pharmaceutical companies are on trial in Ohio. Photo: Kenya's President Uhuru Kenyatta. CREDIT: Tolga Akmen/Pool via REUTERS

Der Nobelpreis in der Kategorie "Physiologie und Medizin" geht diesmal an die zwei Molekularbiologen David Julius und Ardem Patapoutian. Sie haben erforscht, wie wir eigentlich fühlen: Wärme, Kälte, Druck, Berührungen.

David Julius manifestó en La W que "este premio lo que hace es reconocer el trabajo de entender cómo funciona el tacto de los seres humanos".

David Julius e Ardem Patapoutian sono i vincitori del Nobel per la Medicina 2021. Il premio è stato assegnato ai due scienziati, (uno statunitense e l'altro libanese) per la scoperta dei recettori che sono alla base del tatto e dei meccanismi che regolano la percezione del freddo e del caldo.

El Premio Nobel de Medicina 2021 fue para David Julius y Ardem Patapoutian por sus descubrimientos sobre los receptores de la temperatura y el tacto. See omnystudio.com/listener for privacy information.

David Julius y Ardem Patapoutian ganan Nobel de Medicina 2021

Scripps Research scientist Ardem Patapoutian and his partner David Julius at UCSF won the award for their work in discovering how skin receptors allow people to sense temperature and touch. Plus, San Diego State receives a $15 million grant to research Latinx health disparities across San Diego and Imperial counties. Also, the military often falls short in recognizing how the “wounds of war” can lead to incidents of misconduct. How one Marine won a rare victory against the system. Meanwhile, now that California's statewide eviction moratorium has expired, many tenants are looking for rent relief and legal guidance. And, the effort to establish the city's first Black Arts and Culture District to bring resources and revitalization to a long-ignored Encanto neighborhood. Finally, if you've lived in California for long enough, you've probably seen one of those iconic yellow bumper stickers that say "mystery spot." But do you actually know what the 81-year-old roadside attraction called "The Mystery Spot" is all about?

Arturo Barba, nuestro colaborador MVS de ciencia, habló con Luis Cárdenas, sobre el Premio Nobel de Medicina.

Ardem Patapoutian shared The Kavli Prize in Neuroscience in 2020 for answering a basic question: How does touch actually work?

Ardem Patapoutian shared the Kavli Prize in Neuroscience in 2020 for answering a basic question: How does touch actually work?