Podcasts about Piezo

Simon and Nick are back, a week late because Simon forgot what date it was! Nick's trusty microphone then decided to die completely, so he sounds a little different as he had to fall back on his headset, and the master recording crashed and deleted itself before Simon could save it, so this is the Piezo backup recording, which is perfectly OK but doesn't have all the Audio Hijack niceness. Anyway in a month that saw new Apple Macs, and iPads, and Tariff Tomfoolery and much more the boys decide to talk about Simon ordering a 16e, and plastic eating mealworms, amongst other things!!! Recorded 13th April 2025 On this week's show NICK RILEY Spligosh in the Slack Sutton Park Circuit church worship on YouTube Nick's church stream videos on You Tube APPLE Simon orders the iPhone 16e Apple released: iPad Air M3 and A16 iPad launched on March 4 and MacBook Air M4 and M4 Max Mac Studio on March 5. Everything New in the iOS 18.5 Beta – MacRumors How to use Visual Intelligence on iPhone 15 Pro and iPhone 16e – BGR Apple reveals details of security fixes added in iOS 18.4 and more – 9to5Mac Apple TV+ cancels Mythic Quest, allowing new season 4 ending – Cult of Mac The iPad Launched 15 Years Ago Today, Continues To Dominate The Tablet Market – WCCFTech SCIENCE AND TECHNOLOGY Microsoft is now 50 years old – The Verge [Scientists break down cheap plastic using the air – LiveScience Plastic-eating mealworms native to Africa discovered – Live Science SECURITY & PRIVACY Court confirms Apple is suing UK government over encryption backdoor – TechRadar WORTH A CHIRP / ESSENTIAL TIPS You can now buy an Apple Pencil Pro that looks like a crayon – 9to5Mac New Low Price: Add Ports Galore to Your Apple Mac Mini With Satechis – CNET Select Faster on iPhone With This Two-Finger Trick – MacRumors Essential Apple Recommended Services: All Things Secured – Online security made simple by Josh Summers. Pixel Privacy – a fabulous resource full of excellent articles and advice on how to protect yourself online. Doug.ee Blog for Andy J's security tips. Ghostery – protect yourself from trackers, scripts and ads while browsing. Simple Login – Email anonymisation and disposable emails for login/registering with 33mail.com – Never give out your real email address online again. AnonAddy – Disposable email addresses Sudo – get up to 9 “avatars” with email addresses, phone numbers and more to mask your online identity. Free for the first year and priced from $0.99 US / £2.50 UK per month thereafter... You get to keep 2 free avatars though. ProtonMail – end to end encrypted, open source, based in Switzerland. Prices start from FREE... what more can you ask? ProtonVPN – a VPN to go with it perhaps? Prices also starting from nothing! Comparitech DNS Leak Test – simple to use and understand VPN leak test. Fake Name Generator – so much more than names! Create whole identities (for free) with all the information you could ever need. Wire and on the App Stores – free for personal use, open source and end to end encryted messenger and VoIP. Pinecast – a fabulous podcast hosting service with costs that start from nothing. Essential Apple is not affiliated with or paid to promote any of these services... We recommend services that we use ourselves and feel are either unique or outstanding in their field, or in some cases are just the best value for money in our opinion. Social Media and Slack You can follow us on: Twitter / Slack / EssentialApple.com / Soundcloud / Spotify / Facebook / Pinecast Also a big SHOUT OUT to the members of the Slack room without whom we wouldn't have half the stories we actually do – we thank you all for your contributions and engagement. You can always help us out with a few pennies by using our Amazon Affiliate Link so we get a tiny kickback on anything you buy after using it. If you really like the show that much and would like to make a regular donation then please consider joining our Patreon or using the Pinecast Tips Jar (which accepts one off or regular donations) And a HUGE thank you to the patrons who already do. Support The Essential Apple Podcast by contributing to their tip jar: https://tips.pinecast.com/jar/essential-apple-show This podcast is powered by Pinecast.

This week's EYE ON NPI is trendy and buzzy, it's Boréas Technologies' BOS1931 High-Efficiency Piezo Driver (https://www.digikey.com/en/product-highlight/b/boreas/bos1931-high-efficiency-piezo-driver). This chip is a compact way to add powerful high-voltage piezo drive to any product, combining three chips: power supply, waveform generator and driver. With a complete I2C/I3C interface that you can connect to any microcontroller/processor it's the most advanced all-in-one piezo driver we've seen! Piezo (https://en.wikipedia.org/wiki/Piezoelectricity) discs are multi-use devices that convert mechanical movement to electrical signal, and vice-versa. They're most often seen as electrical-to-mechanical converters such as piezo beepers (https://en.wikipedia.org/wiki/Piezoelectric_speaker) where an AC signal, usually 3 to 6V peak-to-peak square wave, is applied across the disk. The frequency of the wave is translated into a sound frequency. It doesn't have the same fidelity as a magnetic speaker but its much thinner, less expensive for the component and driving circuitry, and for 2 to 4 KHz beeps it's just fine. Piezos can also be used the opposite way, where mechanical stress on the crystal is translated into an electrical signal. In this way it can be used as a switch or force sensor (https://en.wikipedia.org/wiki/Piezoelectric_sensor), again usually a few microamperes' worth of current is generated. For these basic uses, your standard microcontroller pin, or at best an H-Bridge will work just fine: you can drive piezo's differentially to get more Vpp across the disc but essentially we're still talking about only a few Volts. There are some times when you want to make a piezo really 'loud' - that is, putting 100+ Volts across the crystal to generate a big mechanical response. This is often not for audible use cases, after all if you wanted to do that you'd just use a magnetic speaker (https://www.adafruit.com/product/1732) that can get to many many Watts of output efficiently. FYI there's two variants of the chip: the BOS1931 (https://www.digikey.com/short/w9tz9tbj) and the BOS1921 (https://www.digikey.com/short/nnb0r29r). The '31 can only do piezo driving. The '21 can do sensing as well as driving, so it can be used for force-feedback products. In this particular EYE ON NPI we'll just be chatting about the driving capabilities of both. So, while we can do basic sensing/beeping with a few Volts - when we want to have significant motion for blasting sonar or moving fluid around we can only increase the movement by increasing the peak-to-peak voltage. Each piezo you buy will have a voltage rating - and you will need a boost converter to generate that peak-to-peak. For the BOS19 series of chips, you can get +-95V so 190Vpp max, which will drive any piezo you find, and you only need 3~5V input thanks to a built-in DC/DC boost converter. Boréas didn't stop there. Not only do you get a booster, but also a full waveform manager with I2C/I3C control. You can can fill up a FIFO buffer with waveform bytes to generate different shapes. There's a sine generator you can control with an envelope creator. Or, you can piece together waveform shapes for different pump/haptic behavior, giving you the customizability of a byte-wise waveform generator with the simplicity of a sine generator. They even have a Haptics Studio' to help you craft the waveform you want (https://www.boreas.ca/pages/haptic-studio). The BOS1931 (https://www.digikey.com/short/w9tz9tbj) and the BOS1921 (https://www.digikey.com/short/nnb0r29r) come in two packages: an easy-to-layout-and-solder QFN and a tiny-and-advanced BGA. Both have the same core so just pick whether you need simplicity or small size. Since its a pretty serious boost converter and driver - the piezo connects directly to the output pins - you'll need to watch your layout. Check the datasheet for their recommended setup to make sure you don't have excessive power loss or EMI. IF you want to get started quickly, the BOS1921-KIT-B01 (https://www.digikey.com/short/v9hn8mcd) evaluation board will let you use their configuration software to quickly determine how your piezo actuator or sensor response to the waveform generator and booster before you start laying out the components on a prototype PCB. If you have some serious piezo-ing you need to get moving, the Boréas Technologies' BOS1931 High-Efficiency Piezo Driver (https://www.digikey.com/short/w9tz9tbj) can do everything from voltage generation, waveform shaping, and differential driving. And best of all it's in stock right now at Digi-Key for immediate shipment! Order today and DigiKey will pick and pack your order in an instant so that you can be vibin' with your fancy new piezo controller by tomorrow afternoon.

Oh my gosh! So much happened today! I promise I tried to do the video casting today but it didn't work. My WIFI is too slow for me to connect with Messenger. We are going to try a ZOOM meeting next. However the screen recorder worked but I had the audio OFF! It's a learning process. I'll see if i can put the audio and the video together some how.  Today Alex and Jessie took us through all the experimentation that they have been doing with noise makers and piezo/mag pups. It was truly interesting. We also discuss ways to work with softer timbers like pine and Oregon for necks and fretboards. Thank you so much for being a part of our show and we truly appreciate you.  Do you know that we have our own website where you can purchase T shirts to help support the show.  www.thecbgbuilder.com Joe Oltean, Darren Macdonald and Jesse Thomas can be reached via the Facebook group You can see what I have been up to on the Facebook group and at www.birdwoodguitars.com Thank you for supporting the show and an enormous THANK YOU to Ben 'Gitty' Baker and the team at C.B.Gitty for supporting the podcast.   If you need to order parts and want to support the show, you can by using our affiliate link https://www.cbgitty.com/?ref=birdwood and if you use the promo code BIRDWOOD you can receive 10% off the price of your first 3 orders with CBGitty.  A reminder that Australian and New Zealand customers benefit from reduced US shipping rates and a free cigar box with every order over US$100. You can purchase KILLER STRINGS from CBGitty.com in the USA and in Australia at www.birdwoodguitars.com Many thanks, Adam Harrison 

Milan-based Piezo (@piezopz) sits at the heart of the current club sounds. He has long had an obsession with sound system music and that defines what he does today: mutant and beguiling club tracks with meticulous sound design and thrilling energy, heavy low ends and a real dose of UK influence from d&b to garage, grime and techno. He kicked off the year by dropping his genre-busting Ecstatic Nostalgia EP on our Dekmantel-UFO sub-label and now returns with a podcast that is just as fresh. It's a futuristic mix of bleeping machines and lurching rhythms with bright synth designs and deep space ambience. Over the course of 90 minutes, the pace picks up and you're whisked along a variety of rhythms from broken to dubby, head spinning to minimal. It feels utterly spontaneous but is also a fully coherent mix from this restless innovator.

In this episode your Four Amigos discuss our latest builds and whether or not it is fair to compare piezo pickups to magnetic pickups. What do you think?  Do you know that we have our own website where you can purchase T shirts and CBGs to help support the show.  www.thecbgbuilder.com Joe Oltean, Darren Macdonald and Jesse Thomas can be reached via the Facebook group You can see what I have been up to on the Facebook group and at www.birdwoodguitars.com Thank you for supporting the show and an enormous THANK YOU to Ben 'Gitty' Baker and the team at C.B.Gitty for supporting the podcast.   If you need to order parts and want to support the show, you can by using our affiliate link https://www.cbgitty.com/?ref=birdwood and if you use the promo code BIRDWOOD you can receive 10% off the price of your first 3 orders with CBGitty.  A reminder that Australian and New Zealand customers benefit from reduced US shipping rates and a free cigar box with every order over US$100. Many thanks, Adam Harrison 

Novedades: Joy Orbison, Jamie xx, Undo & Casiowaves, Mechatok, Sunareht (Lunice Remix), Piezo, Phonique, Tee Mango, Boo Williams, Frits Wentink, Wata IgarashiDisco de la semana: SkygazeEspecial: Innervisions (2)La Perla: Luc Van AckerEscuchar audio

BEST OF 2024 featuring THE BUG, DJRUM, DRUMSKULL, CHATEAU FLIGHT, FCUKERS, FLOATING POINTS, GLASS BEAMS, JONNY FROM SPACE, PIEZO, SAM LINK, SISTER ZO + SAM BINGA + AMY KISNORBO, SKEE MASK, THREE HANDS OF DOOM, TSHA + many more on this extended ABSTRACT SCIENCE year-in-review podcast. Co-hosts CHRIS WIDMAN, BILL BEARDEN aka WHOA-B, JOSHUA P... The post best of 2024 – absci radio 1346-1347 appeared first on abstract science >> future music chicago.

Piezo touch and pressure-sensing ion channels are showing up everywhere as the explanation for physiologic phenomena, both at the macro and micro levels. Ardem Patapoutian, my friend and colleague at Scripps Research, discovered these receptors back in 2010 and was awarded the Nobel Prize in 2021 for his work. As you'll see/hear from our conversation, the field has exploded. And you'll get to know Ardem, who is such a fun, charismatic, and down-to-earth person. He also recently got a unique tattoo (videos below) and I wonder (unlikely) if any other Nobel laureates have one related to their discovery?!Below is a video clip from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The current one is here. If you like the YouTube format, please subscribe! The audios are also available on Apple and Spotify.Transcript with links to audioEric Topol (00:07):Well, hello. It's Eric Topol with Ground Truths, and I've really got a special guest today. The first time for the podcast, I've been able to interview a colleague and faculty at Scripps Research, Ardem Patapoutian, who just by the way happens to be the 2021 Nobel Laureate in Physiology or Medicine. So welcome, Ardem. It's so wonderful to have you.Ardem Patapoutian (00:30):Thanks so much, Eric. Looking forward to chatting with you.Eric Topol (00:34):Well, this has been interesting because although I've known you for several years, I didn't research you. I mean, I had to learn about more than I even do. And of course, one of the great sources of that is on the Nobel Prize website where you tell your whole story. It is quite a story and not to review all of it, but I wanted to go back just before you made the call to move to Los Angeles from Beirut, Lebanon and with the scare that you went through at that time, it seemed like that was just extraordinary that you had to live through that.Ardem Patapoutian (01:11):Yeah, so I am of Armenian origin, but I was born in Lebanon and born in 1967, so I was eight years old when the civil war started. So it's a kind of bizarre childhood in the sense that with all the bombs and fighting in Lebanon. So it was tough childhood to have, but it was never personal. It was bombs and such. And so, the event you're talking about is, I happened to be kidnapped while crossing East to West Beirut. They only held me for four or five hours at first asking me questions to see who I am, but I think they pretty soon figured out that I was not a dangerous guy and they ended up letting me go. But before that, that incident really had a huge impact on me so that by the time I got home, I literally said, I'm out of here. I'm going to find a way to leave the country. And so, that's what, very quickly within a few months I packed and came to United States.Eric Topol (02:19):And how did you pick LA to be your destination?Ardem Patapoutian (02:22):Being from the Armenian community, there's a lot of Armenians in Los Angeles. My cousins already had moved there. They also grew up in Lebanon. And my brother, who's a few years older than me, got admitted to USC graduate school in engineering. So he was going to be there. So it made a lot of sense.Eric Topol (02:44):Oh yeah.Ardem Patapoutian (02:45):Unlike him, I came with no school or job prospects because it happened so fast that I kind of just left. One year I was at American University of Beirut for one year, but then just left and came here. So worked for a year in various jobs and then started going back to school to UCLA.Eric Topol (03:07):Yeah, I saw how there was about a year where you were delivering pizzas and before you got into UCLA, and that must have been an interesting off year, if you will. Well, the story of course, just to fast forward, you did your baccalaureate at UCLA, your PhD at Caltech, postdoc at UCSF, and then you came to Scripps Research 24 years ago along with Pete Schultz, and it's been quite an amazing run that you've had. Now, before we get into PIEZO receptors, the background, maybe you could help me understand, the precursor work seems to be all related to the transient receptor potential (TRP) series, also ion channels. They were of course related to whether it was heat and temperature or somatosensory. How do these channels compare to the ones that you discovered years later?Background on these Ion ChannelsArdem Patapoutian (04:09):Yeah, so the somatosensory neurons that innervate your fingertips and everywhere else in your body, their main job is to sense temperature and pressure. And this is very different than any other neuron or any other cell. So when you touch a hot stove that's burning hot, you need to know about that immediately within milliseconds or something cold. So the opposite side of it is pressure sensing, and it also comes in light touch, which is pleasant or a hammer hitting your finger, which is unpleasant. But all of these have the same characteristic anyway, that is your body has learned at the molecular level to translate a physical stimulus such as temperature and pressure into an electrical signal that neurons use to communicate with each other. But this idea of how you translate physical stimuli into chemical or electrical signal has been a long open question because as you know, most of our cells communicate by chemicals, whether that's hormones or small molecules, we know how that works, receptor bind to ligand, confirmational change and you get a kinase activation and that's enough. But here, how do you sense pressure? How do you sense temperature? It was just, there wasn't much known about that. And that's why our earlier work on TRP channels, which were temperature sensors came before the pressure. And so, they're very related in that sense.Eric Topol (05:52):The structure of these, if you were to look at them, do they look pretty similar? What the TRP as you say, and what you did back in the 2010 Science paper, which we'll link to, of course the classic paper where you describe PIEZO1 and PIEZO2, but if you were to look at this structures, would they look pretty similar?Ardem Patapoutian (06:14):No, that's a good question. And they absolutely don't. That's why finding these receptors were so hard. So if you go back to other sensory receptors, vision rhodopsin G-protein coupled receptor (GPCRs), larger G-protein coupled receptor look the same. So for example, when it was identified by chemically, that smell also works through G-protein coupled receptor. Richard Axel and Linda Buck, who also won the Nobel Prize, found those receptors by homology to visual GPCRs. The ion channels other than the fact that they crossed the membrane a few times or more, they have nothing else in common. If you looked at their structure, you can't even immediately tell they're ion channels. So you couldn't find these by structural homology or sequence homology. So you had to do something else. And usually that means functional screens and et cetera.Eric Topol (07:09):Well, yeah, and I'm in touch with the screening. We'll get to that and how you dig these up and find them. But the somatosensory ones are really interesting because I don't think a lot of people realize that when you have wasabi or you have Listerine mouthwash and feel the burn and that these are all mediated through these channels, right?Ardem Patapoutian (07:35):Yeah. So there's this whole field of chemesthesis, which means senses in your mouth, for example, that are not explained by taste transduction and olfactory. And these are actually by the same somatosensory neurons that help you sense temperature and pressure. And some of these receptors are the same. Their evolution has taken over and used them for many different things. The prime example of this is the capsaicin receptor that David Julius my co-laureate identified, which is also heat receptors. So all languages describe chili peppers as hot, and that's not a coincidence. It actually activates heat activated channel, and that's why we think of it as hot. And so, the same goes to another one of these TRP channels that you mentioned, which is TRPA1, and this one is also activated, but a lot of spicy foods other than the chili pepper active ingredient includes what's in garlic and onions and everything that has this burning sensation and chemicals of this and wasabi and chemicals of this are used in over the counter products like Listerine that cause that burning sensation.Eric Topol (08:54):So when you're chopping onions and it makes you cry, is that all part of it as well?Ardem Patapoutian (08:59):That's all TRPA1, yeah.The Discovery, A Test of PerseveranceEric Topol (09:01):It's wild. Now, this was the groundwork. There were these heat temperature and somatic sensory, and then you were starting to wonder what about touch, what about out pressure and proprioception. And so, you went on a hunt, and it's actually kind of an incredible story about how you were able to find out of these cells that you had, screening hundreds or I guess you got to 72 different small interfering RNA blocking that you finally found the one. Is that right?Ardem Patapoutian (09:37):That's right. So in retrospect, looking back at it, I think there's such an interesting scientific message there. And so, many of us were looking for this touch pressure sensors and we were all looking in the DRG sensory neurons that are complicated heterogeneous, they don't divide. It's not easy to do a screen on them. And ultimately after a lot of failures, what worked for us is to take a step back and ask a much more simpler question. And that was, can we find one of these cell lines that you could easily homogeneously grow in a culture dish, if they respond to mechanical force, can we find our channel there? And then go back and look if it's relevant in vivo for what process. So I think the message is ask the simplest question to answer the question you're after. And finding what that is, is actually the challenge lots of times.Ardem Patapoutian (10:36):But yeah, that's what Bertrand Coste in my lab did is found a simple cell line that neuroscientists had been using for a hundred years and somehow found that they over overexpressed this channel because you can record from them, you can push them and record the currents from them. And then it became a simpler question of finding it. It still took a whole year. He made a list and one by one knocking them out and looking at it. And finally, as you say, number 72 was the hit. When he knocked that out, the current was gone. And that's where we started believing that we have what we were looking for.Eric Topol (11:12):Were you all ever about ready to give up at that point?Ardem Patapoutian (11:16):Oh yeah. I mean that's another lesson. These are postdocs doing the work, right? And they're here three, four years and this was coming close to end of two years, and he didn't have anything yet. So we started talking about having a backup project and he started that and we said, okay, we were ordering this oligos 30 at a time because they're expensive. And so, the first 30 nothing, the second 30 nothing. And how many more are we going to do before we potentially give up? And we said, well, let's do at least a third and then decide, thank goodness it was in that last set.Eric Topol (11:54):Wow, that is so wild. Now what's happened since this discovery, which I guess when you published it in 2010, so it means 14 years ago, but we're on this exponential growth of learning that these piezo receptors are everywhere. They're doing everything. In fact, I recently put on Bluesky, PIEZO ion channels are to human physiology as GLP-1 drugs are to treating many diseases because it's just blowing up. And you've published on some of these of course, on itch and bladder function and vascular function. We'll get to maybe malaria, I mean, but even the cover of Science recently was about wet dog shakes and how animals shake because of water. These receptors are so fundamental to our function. So maybe you could comment, 15 years ago when you were doing the work and you're making this discovery, did you ever envision it was going to blow up like this?Ardem Patapoutian (12:57):Not to this level, but I should have. I think that this idea, again, that most of cell communication is through chemicals is of course a lot of it is true.Ardem Patapoutian (13:12):But it would be ridiculous for evolution to ignore all the physical forces, the pressures that cells experience. And once they do, you would think you would put an instructive way of sensing this pressure signal and using it beneficially to the system or the cell. And so, when we used to talk about pressure sensing at the beginning, there were a couple of touch, pain, maybe proprioception, hearing are like the poster children of pressure sensing. But I think what these molecules, as you say is enabling us is finding out the much more wider role that pressure sensing is playing in physiology and in disease that no one had thought seriously about. And this is, I compare sometimes the finding the PIEZO molecules. You're going in a dark room, and you need to find a door to get into there. And PIEZO is kind of that finding the door once you get in, now you use that molecule now to find physiology instead of the opposite way around. So by pursuing PIEZO expression and function, we're finding all these new roles that they play in physiology and in disease that we didn't think about. And because they're so specialized to sense tension, membrane tension, they don't do anything else. So if you see them expressed somewhere or if you see a function for them, you can bet that they are playing a role in sensing pressure. A lot of biology has kind of come from this hypothesis.Eric Topol (15:00):Well, I mean it is so striking to see the pervasiveness, and I do want to go back just for a second because when you name them PIEZO, you named it after the Greek word. How did you come to that name?Ardem Patapoutian (15:13):So Bertrand and I were actually sitting on Google Translate and we were typing pressure and trying to see what it's like in Greek or in Latin or different languages. His native French and my Armenian and píesi in Greek is pressure. And of course, what's really cool is that the word that more people know about this is piezoelectric device.Eric Topol (15:41):Oh, right.Ardem Patapoutian (15:41):Actually, translates physical force into electricity and vice versa. And in a way, this is a little molecular machine that does the same thing, and he uses this piezoelectric device to actually push on the cell. That's his assay. So it all came together as a very appropriate name for this gene and protein.Call from the Nobel CommitteeEric Topol (16:04):Oh really, it's perfect. And you get to name it, even that's fun too, right? Now we're going to go to getting the call at 2:00 AM, but it didn't come to you because your phone from the Nobel Committee was on ‘do not disturb' and your 94-year-old father, Sarkis. How did the Nobel Committee know to get ahold of him? How did they reach him in the middle of the night?Ardem Patapoutian (16:37):Yeah, so I mean, since receiving it, I've had conversations with various committee members, and they are very resourceful folks, and they have assistants who throughout the year collect information on all potential people who might win. They're also doing last minute searches. So they looked for other Patapoutian's in California. So they just called my dad who initially yelled at them for disturbing him at 2:00 AM.Eric Topol (17:17):And he could get through to you because he was not on your list of ‘do not disturb' or something like that.Ardem Patapoutian (17:22):I didn't even know this. And I don't know if the policy has changed, but in some phones the ‘do not disturb' if it's called by someone who's in your contacts or favorites.Ardem Patapoutian (17:34):After I think they called twice and they get through, and that's how.Getting a Tattoo!Eric Topol (17:39):That's amazing. Wow. Well, that's quite a way to find out that you're getting recognized like this. Now recently you got a tattoo, which I thought was really remarkable, but we're going to put that of course in the post. Tell us about your decision to get the PIEZO channel on your arm.Ardem Patapoutian (18:02):So as you can tell, I'm obsessed about PIEZO and it's been good to me. And I had the idea a while ago, and my very wise wife, Nancy Hong, said that you might be going through midlife crisis. Why don't you wait a year? If you still believe in it, you should do it. And that's what I did. I waited a year, and I was like, I still want to do it. And I guess I could show it. Here it is.Eric Topol (18:32):Oh yeah, there it is. Oh wow.Ardem Patapoutian (18:33):What's cool is that I can pretty much flex to show the activation mechanism because the channel is like bent like this in the plasma membrane. When it's stretched, it opens and it actually flattens like this. So I feel like other than being a tattoo, this is both performance art and instructional device. When I'm giving talks without PowerPoint slides, I could give a demonstration how this ion channel works.[Below is from a presentation that Ardem recently gave, the Harvey Lecture, at Rockefeller University.]Eric Topol (19:04):It's wild. Now how did you find a tattoo artist that could, I mean, it's pretty intricate. I mean, that's not your typical tattoo.Ardem Patapoutian (19:14):Yeah, I put it up on social media that I was thinking of doing this, and many scientists are into tattoos, so I actually got so many recommendations. And one of them was a local here in San Diego, and she is very popular. I waited six months to get this, I was on a waiting list. The appointment was six months off when we made it. So she's very popular and she's very good.Eric Topol (19:45):Was it painful to get that done?Ardem Patapoutian (19:47):Well, that's actually really cool, right? Because PIEZO2 is involved in pain sensation, and I felt it while it was being tattooed on my arm. The whole day, I was there like six and a half hours.New Prospect for Pain MedicationEric Topol (20:00):Oh my gosh. Wow. Now that gets me to pain because, I'd like you to talk a bit about the people that don't have mutations or loss of function PIEZO receptors and also what your thoughts are in the future as to maybe we could develop a lot better pain medications.Ardem Patapoutian (20:22):Yeah, we're working on it. So you're right. One of the great parts of the science story, and this is mainly the work of Alex Chesler and Carsten Bönnemann at the NIH, where they identified people who came to the clinic for undiagnosed conditions, and they were uncoordinated and had difficulty walking. And when they did whole-exome sequencing, they found that they had mutations in PIEZO2, there were loss of function, as you say. So complete loss on both chromosomes. And when they started testing them, they realized that just like we had described them in animal models, humans without PIEZO2 as well, didn't sense touch, don't have proprioception. This sense of where your limbs are, that's so important for balance and most other daily functions that we take it for granted. So they were completely lacking all of those sensations. They also do not feel their bladder filling.Ardem Patapoutian (21:26):And so, they have learned to go on a schedule to make sure they don't have accidents. And many of these projects that we've done in the lab collaboration with Alex Chesler, et cetera, have come from the observations of what else these individuals experience. And so, it's been a great kind of collaboration communication between mechanistic animal model studies and the clinic. And so, one of the things that these individuals don't sense in addition to touch, is something called tactile allodynia, which is simply when touch becomes painful. You and I experienced this after small injury or sunburn where just touching your shoulder becomes painful, but for peripheral neuropathy and other neuropathic pain conditions, this is one of the major complaints that individuals have. And we know from the NIH studies that these individuals don't have this tactile allodynia. So touch becomes painful and doesn't apply to them, which tells us that if we block PIEZO2, we can actually get interesting relief from various aspects relative to neuropathic pain on other pain related neuropathies. But given everything we talked about, Eric, about how this is important for touch and proprioception, you don't want to make a pill that blocks PIEZO2 and you take it because this will have some serious on target side effects. But we are developing new compounds that block PIEZO2 and hope that it might be useful, at least as a topical medication pain and other indications. And we're actively working on this, as I said.Eric Topol (23:15):Yeah, I mean the topical one sounds like a winner because of peripheral neuropathy, but also I wonder if you could somehow target it to sick cells rather than if giving it in a systemic targeted way. I mean it has tremendous potential because we are on a serious hunt for much better relief of pain than exists today.Ardem Patapoutian (23:41):Absolutely.Eric Topol (23:42):Yeah. So that's exciting. I mean, that's another potential outgrowth of all this. Just going back, I mean the one that prompted me in November to write that about the human physiology in PIEZO, it was about intestinal stem cell fate decision and maintenance. I mean, it's just everywhere. But the work you've done certainly now has spurred on so many other groups to go after these different and many unanticipated functions. Were there any ones, of course, you've been pretty systematically addressing these that actually surprised you? You said, oh, are you kidding me when you read this? I never would've guessed this, or pretty much they followed suit as things were moving along.Ardem Patapoutian (24:33):So one of them is this role in macrophages that I found fascinating that we found a few years ago. So again, this came from human studies where PIEZO1 gain-of-function mutations. So in relation to loss of function, their gain-of-function where there's more activity given a certain amount of pressure. They have dehydrated red blood cells, which I'm not going to talk about right now. But they also have shown that in these patients, individuals, it's not really that pathological. They also have age-onset iron overload. What does that have to do with pressure sensing? And we brought that information into animal models, and we found that macrophages, their rate of phagocytosis depends on PIEZO, so that if you have too little PIEZO, they don't phagocytosis as much. If you have too much PIEZO, the phagocytosis too much. And this increased rate of phagocytosis in the long term because it's constantly eating red blood cells and the iron is circulating more causes long-term effects in iron overload. And again, as you kind of set that up, who would've thought that mechanical sensation is important for this basic hematology type?Eric Topol (25:52):Yeah, I mean, because we've been talking about the macro things, and here it is at the cellular level. I mean, it's just wild.Ardem Patapoutian (25:59):If you go back and look at a video of a macrophage eating up red blood cells, then you go, oh, I see how this has to do with pressure sensing because it is like extending little arms, feeling things letting go, going somewhere else. So again, I want to bring it back by this simple cell biological function of a cell type, like macrophage, exploring its environment is not just chemical, but very mechanical as well. And so, in retrospect, it is maybe not that surprising, that pressure sensing is important for its physiology.Career Changing?Eric Topol (26:33):Yeah, that's extraordinary. Well, that gets me to how your life has changed since 2021, because obviously this a big effect, big impact sort of thing. And I know that you're the first Armenian, first person from Lebanon to get this recognition. You recognized by the Lebanese Order of Merit. There's even a stamp of you, your picture characterized in 2022.Eric Topol (27:04):So if you were to sum up how it's changed because I see no change in you. You're the same person that has a great sense of humor. Often the tries to humor relaxed, calming. You haven't changed any to me, but how has it affected you?Ardem Patapoutian (27:26):Thank you, Eric. That's very kind of you. I try very hard for it not to change me. I do get a little bit more attention, a ton more invites, which unfortunately I have to say no to a lot of them because, and I'm sure you're very familiar with that concept and a lot of things are offered to you that I feel like it's so tempting to say yes because they're wonderful opportunities and an honor to be asked. But the end of the day, I'm trying to be very disciplined and not taking things on that I can do as an opportunity. But things that I really want to do. I think that's so hard to do sometimes is to separate those two. Why am I doing this? Is this really important for the goals that I have? So in one way, the answer for that is that I just want to stay in the lab and do my research with my students and postdoc, which is what I enjoy the most. But on the other hand, as you said, being the first Armenian who's received this, literally after the Nobel, I got this whole elementary school, all Armenian kids write to me multiple letters.Ardem Patapoutian (28:39):And they said, you look like me. I didn't think I could do this, but maybe I can. So in a sense, to ignore that and say, no, I just want to do my science, I don't want to be involved in any of that is also wrong. So I'm trying to balance being engaged in science outreach and helping to make science understood by the general public, realize that we're just regular people and at the same time how awesome science is. I love science and I like to project that, but leave plenty of time for me to just be a scientist and be in my lab and interact with my colleagues at Scripps, including you.Immigrant ScientistsEric Topol (29:21):Well, we're so lucky to have that chance. And I do want to mention, because you're prototyping in this regard about great immigrant scientists and other domains of course, but every year the Carnegie Foundation names these great immigrants and one year you were of course recognized. And in recent years, there have been more difficulties in people wanting to come to the US to get into science, and they wind up going to other places. It seems like that's a big loss for us. I mean, what if we weren't able to have had you come and so many hundreds, thousands of others that have contributed to this life science community? Maybe you could comment about that.Ardem Patapoutian (30:10):Yeah, I think it is tragic, as you say. I think in some circles, immigrants have this negative image or idea of what they bring, but at every level, immigrants have contributed so much to this country. It's a country of immigrants, of course, to start with. And I think it is important to put up a positive image of immigration and science is the ultimate example of that, right? I mean, I think when you go into any laboratory, you probably find if there's a lab of 16 people, you probably find people from 10 different countries. And we all work together. And the idea of also immigrant and especially about science is that I'm a big believer of changing field, changing things because just like that, immigrants have changed their whole life. So they come to a new culture, they bring with them their own way of thinking and their way of seeing things. And then you come into a new environment, and you see it a little bit differently. So that kind of change, whether it's because of physical immigration or immigrating from one field to another in science is really beneficial for science and society. And I think positive examples of this are an important part of highlighting this.Eric Topol (31:40):I couldn't agree with you more really.Bluesky vs Twitter/XEric Topol (31:41):Now, speaking of migration, there's been recently a big migration out of X, formerly Twitter to Bluesky, which I like the metaphor you liken to the Serengeti. Can you tell us about, now I know you're posting on Bluesky and of course so many others that you and I are mutual contacts, and our different networks are. What do you think about this migration outside of what was the platform where a lot of this, we shared things on X or before Musk took over known as Twitter? Thoughts about Bluesky?Ardem Patapoutian (32:27):Yeah, I think I use social media for a few reasons. The number one reason should be is to see new science by colleagues. My main point is that, but also, again, having fun in science is a big part of my draw to this. And as you can see from my posts, it's a bit lighthearted, and that's really me.Eric Topol (32:52):Right. Yeah.Ardem Patapoutian (32:52):I think on Twitter, things start getting a little bit dark and too many negative comments, and it was just not productive. And I just felt like after the elections, I felt like it was time to migrate. And I find Bluesky a great scientific community, and it's remarkable how quickly people have migrated from Twitter to Bluesky. But the counter argument for this is that you should stay in a place where majority of people are, because being in a bubble surrounding yourself by people like you doesn't help society. And so, I get that perspective as well. It just depends on what you're using the platform for and it's a difficult issue. But yeah, I've taken a break probably long-term break from Twitter. I'm on Bluesky now.Eric Topol (33:48):Yeah, no, the point you're bringing up about the echo chamber and is there going to be one for people that are leaning one way and they're thinking, and another with a whole different, often politically charged and even extreme views? It's really unfortunate if it does wind up that way. But right now, it seems like that migration is ongoing and it's substantial. And I guess we'll see how it settles out. I share your concern, and so far, I've been trying to keep a foot in both areas because I think if we all were to leave, then we're just kind of caving into a, it's tricky though. It really is because the noxious toxic type of comments, even when you try to avoid comments, you say, only followers can make a comment, they'll of course, quote your thing and then try to ding you and whatever. It's just crazy stuff, really.Ardem Patapoutian (34:53):I mean, what I think is that, that's why I said depends on why. I mean, your presence on social media is such an important part of science education. And I could almost say you can't afford to do what I do, which is I'm just putting my goofy posts and having fun. So we have different purposes in a way, and yeah, that affects what you use and how you use it.Eric Topol (35:17):Yeah, no, it's tricky it really is. We covered a lot of ground. Is there anything I missed that you want to get out there? Any part of this, your story and the PIEZO story, science and everything else that I didn't bring up?The Essentiality of Basic ScienceArdem Patapoutian (35:42):I just think that the basic science community is really suffering from decreasing amounts of funding and appreciation of doing basic science. And one of my goals, in addition to this immigrant scientist thing, is to remind people that all medicines start with basic science work. And funding this has mainly been through NIH and it's getting harder and harder for basic scientists to secure funding and I'm really worried about this. And we need to find ways to be okay for people to do basic science. And I'll give you one example. Whenever we make a publication and there's a journalist talking to us or some kind of press coverage, they ask, how is this directly affecting patients? And my work actually is very much related to patients, and I answer that question, but I also say, but it's also important to do science for the science sake because you don't know where the applications are going to come from. And we need to, as a society, encourage and fund and support basic science as the seeds of all these translational work. And I think doing that just kind of highlights that this is important too. We should support it, not just things that right now seem very related to translational that directly helps patients.Eric Topol (37:16):Well, I'm so glad you emphasized that because I mean, the PIEZO story is the exemplar. Look what's come of it, what might still come of it. In many respects here you are maybe 15 years into the story and there's still many parts of this that are untold, but if it wasn't for the basic science, we wouldn't have these remarkable and diverse insights. And recently you cited, and I think so many people read about the ‘crown jewel' NIH, front page New York Times, and how it's under threat because the new NIH director doesn't have a regard for basic science. He's actually, he's confirmed, which is likely, he's an economist, physician economist, never practiced medicine, but he doesn't really have a lot of regard for basic science. But as you point out, almost every drug that we have today came out of NIH basic work. And I mean, not just that, but all the disease insights and treatments and so much.Eric Topol (38:25):So this is really unfortunate if we have not just an NIH and other supporting foundations that don't see the priority, the fundamental aspect of basic science to then lead to, as we call translational, and then ultimately the way to promote human health, which is I think what we're all very much focused on ultimately. But you can't do it without getting to first base, and that's what you have done. You served it up and it's a great example. Well, Ardem, it's always a pleasure. This is a first time talking through a podcast. I hope we'll have many, many visits informally that will complement the ones we've already had, and we will follow the PIEZO work. Obviously, you have had just an exceptional impact, but you're still young and who knows what's next, right? I mean, look what happened to Barry Sharpless. He won here. He won two Nobel prizes, so you never know where things are headed.Ardem Patapoutian (39:36):Thank you, Eric, and I really appreciate what you do for the biomedical community. I think it's wonderful through your social media and this podcast, we all appreciate it.***********************************************************************************Please take a moment to complete the poll above.Thank you for reading, listening and subscribing to Ground Truths.If you found this informative please share it!All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and of course appreciated. All proceeds from them go to support Scripps Research. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. I welcome all comments from paid subscribers and will do my best to respond to each of them and any questions.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research.And Happy New Year! Get full access to Ground Truths at erictopol.substack.com/subscribe

More interesting mailbag! 00:00 – Forest M Mimms Make: Maverick Scientist: My Adventures as an Amateur Scientist https://amzn.to/4e7fSup Signed copies: https://www.makershed.com/products/maverick-scientist-hardcover Engineers Mini Notebook are still available! https://amzn.to/3zvSkjJ https://amzn.to/3XLRJnn https://amzn.to/3XLMHY7 https://amzn.to/4dd9cJQ In the Lab with Jay Jay: https://www.youtube.com/@InTheLabWithJayJay 03:30 – Unmanaged615 https://www.reddit.com/r/TheAmpHour/ 04:40 – Piezo tranducer sensor thing + singing capacitors and hydrophones 08:18 – …

1. Good Weather for an Airstrike - Indian Summer 2. The Inward Circles - To Return Not Unto Ashes but Unto Dust Againe 3. Klein – Storm 4. Moss Covered Technology - Travelling by Night 5. Erik K Skodvin - A Silent Moment In The Periphery 6. Stijn Hüwels - Falling Head Over Heels / Fiat Lux 7. More Eaze, Pardo & Glass - Weather Underground 8. V. Kristoff, Yu Ogu, Precipitation – I 9. Yann Novak - Traversing the Substrate 10. Pjusk & Arovane – Breathing 11. ILUITEQ - New Reality / Found In Silence 12. Piezo - p°P° 13. Cowboy Sadness – Range 14. Mixmaster Morris, Jonah Sharp, Haruomi Hosono – Waraitake / Quiet Logic 15. Matmos - Music or Noise? 16. Philip Glass - Walk to School (feat. Paul Leonard-Morgan) X 2

Take a sneak peak at this month's Fertility & Sterility! Articles discussed this month are:   4:33 A randomized controlled trial to compare the live birth rate of the first frozen embryo transfer following the progestin-primed ovarian stimulation protocol vs. the antagonist protocol in women with an anticipated high ovarian response 20:24 Improved fertilization, degeneration, and embryo quality rates with PIEZO–intracytoplasmic sperm injection compared with conventional intracytoplasmic sperm injection: a sibling oocyte split multicenter trial 31:15 A comparison of pregnancy outcomes and congenital malformations in offspring between patients undergoing intracytoplasmic sperm injection and conventional in vitro fertilization: a retrospective cohort study 37:05 A follicular volume of >0.56 cm3 at trigger is the cutoff to predict oocyte maturity: a starting point for novel volume-based triggering criteria 47:35 Midluteal serum estradiol levels are associated with live birth rates in hormone replacement therapy frozen embryo transfer cycles: a cohort study 57:10 First pregnancy and live birth from ex vivo-retrieved metaphase II oocytes from a woman with bilateral ovarian carcinoma: a case report 1:00:56 Associations between race and ethnicity and perioperative outcomes among women undergoing hysterectomy for adenomyosis   View Fertility and Sterility June 2024, Volume 121, Issue 6: https://www.fertstert.org/issue/S0015-0282(24)X0005-9   View Fertility and Sterility at https://www.fertstert.org/  

Novedades: Tupperwear, Piezo, Hagop Tchaparian, Koreless, Two Shell, Hodge, Sully, Pau Roca, Lele Sacchi, Blende, DJ Seinfeld, Eversines, Krystal KlearDisco de la semana: Divorce From New YorkMini-mix: Promising/YoungsterLa Perla: G.F.X.Escuchar audio

Rosinbomb (OTC:ROSN) proudly announces a significant patent filing, showcasing the unique and proprietary air circulation system of the Nature Fresh Freeze Dryer. This innovation includes a revolutionary Piezo electric fan system seamlessly integrated into their innovative honeycomb rack system, optimizing airflow and enabling customers to process nearly twice the amount of material in the same time. Global biotechnology leader CSL (ASX:CSL; USOTC:CSLLY) and Arcturus Therapeutics (Nasdaq: ARCT) announced the results of a follow-up analysis of a Phase 3 study evaluating a booster dose of ARCT-154. The new analysis at 6 months post-vaccination shows that ARCT-154 induces a longer immune response as compared to Comirnaty for both the original Wuhan strain and Omicron BA.4/5 variant. For more information, please visit StockDayMedia.com

Novedades: Panoram, Nin3s, Piezo, V.I.V.E.K, Ikonika (Girl Unit Remix), Maoupa Mazzocchetti & Clara!, Josh Caffe, Marcellus Pittman, Arnau Obiols & Kayak, Iñigo Vontier, Wallace, Caribou, Lost Souls Of Saturn (Pangaea Remix)Disco de la semana: Phelimuncasi & Metal PreyersEspecial: L.E.V.La Perla: Genius Of TimeEscuchar audio

In this topic we will discuss the use and utility of MEM's sensors for vibration analysis. We will compare attributes of legacy Piezo electric sensors vs MEM's including how each works, and strengths & weakness of each. We then discuss how we can leverage the MEM's sensor in a wireless sensor package and what results we see in using MEM's for impact detection.Speaker:Steven Hudson, Director, Professional ServicesRemote Analysis ServicesReciprocating Analysis ServicesField ServicesBackground:35 years in PdMISO Cat IV Vibration AnalystNaval Nuclear Power Engineering (Submarines)SME Marine, Steel, Food, Combustion Engine► Register for an upcoming webinar here: https://flukereliability.info/bpw-frr

NovedadesNovedades: Nev.Era, Park Hye Jin, Ron Morelli, Piezo, 96 Back, Escaflowne, Lauer, Theus Mago, Voodoos & Taboos, Felipe Gordon, He Isn't Yours, Nikki Nair & Addison GrooveDisco de la semanaDisco de la semana: Benjamin FröhlichEspecialEspecial: CloneLa PerlaLa Perla: Eat MeatEscuchar audio

BEST OF 2023, featuring ANDREA, HUDSON MOHAWKE + NIKKI NAIR, JAMES HOLDEN, NABIHAH IQBAL, OVERMONO, PEVERELIST, PHILIP D KICK, PIEZO, PURELINK, SLOWDIVE, WATA IGARASHI + many more, on this extended ABSTRACT SCIENCE year-in-review podcast. Co-hosts CHRIS WIDMAN, BILL BEARDEN aka WHOA-B, JOSHUA P FERGUSON + HENRY SELF mix 4 hours of future music favorites from... The post best of 2023 – absci radio 1293-1294 appeared first on abstract science >> future music chicago.

The advantage of piezo-surgery is multi-faceted. It's ideal for minimizing patient discomfort following virtually all oral surgery procedures. It many cases it obviates the need to create a surgical flap, helps protect adjacent teeth and restorations during extractions, precisely cuts hard tissue while precluding injury to soft tissue. When cutting, it produces negligible heat which is critical in maintaining vitality of adjacent tissue. And these are just a few of the major advantages of using piezo technology in oral surgery and periodontics. To tell us all about it is our guest Dr. Todd Engel. Dr. Engel has extensive experience in Dental Implants, CT Guided Surgical Design, and Complex Treatment Planning as well as Full Mouth Rehabilitation. He established the Engel Institute, located in Charlotte, NC, which focuses on live patient education with topics ranging from implant placement, grafting, and full arch conversion surgery. The Institute's implant courses have been taught across US and its alumni consists of well over 12,000 dental professionals.

Today I want to tell you about our sponsor for this episode,  Olsen  Dental  Chairs!‍‍Imagine you're a dentist and you spend your whole day around the chair...   Well, Olsen has over  40 years of experience in making those long hours as comfortable as possible for both the dentist  and the patient! ‍If you're a dental professional looking for high quality, cost effective, dental equipment, check out Olson dental chairs!Click this link and mention this episode for a limited time FREE installation with your purchase!‍Guest: Rhonda KalashoPractice Name: TruGlow Mordern DentalCheck out Rhonda's Media:Practice Website: https://glomoderndental.com/Email: rhondakalasho@glomoderndental.comInstagram: https://www.instagram.com/dr.rhondakalasho/Facebook: https://www.facebook.com/dr.rhondakalasho‍Other Mentions and Links:‍Tools/Resources:HubSpotHubSpothttps://www.googleadservices.com/pagead/aclk?sa=L&ai=DChcSEwjjuryZn42DAxXKB60GHWZzBfYYABAAGgJwdg&ase=2&gclid=Cj0KCQiAyeWrBhDDARIsAGP1mWSmA-wnuIpk3AgrP6Q4LOTx7tZpTWkt9X_vnRvjxA6TpHggzdgGerIaAoxFEALw_wcB&ei=6xJ6ZaSIDeGC0PEP-5GPaA&ohost=www.google.com&cid=CAESV-D2LJrATp36pfi4qgGRCTKgaEIqiHzgIfDNWGIzDXafM7fx84q8a9o3MfxOBrhzqXvVlJtKltzCsaJOIqike632B7HWKepVIukxm2wCNCtob28pZUpKag&sig=AOD64_0lSViVPzY6D95mLKOsmbn2Bwj18A&q&sqi=2&nis=4&adurl&ved=2ahUKEwjkqbaZn42DAxVhATQIHfvIAw0Q0Qx6BAgJEAETrainualPearl (AI software)TurboTaxGoogle AdsCompanies/Brands:BBCMSNBCForbesZocDocInvisalignTerms:HMOMedi-CalROI - Return on InvestmentEBITDA - Earnings Before Interest, Taxes, Depreciation, and AmortizationWet DentistryOL - Oral LeukoplakiaAI - Artificial IntelligenceSEO - Search Engine OptimizationPPC AdsLLC - Limited Liability CompanyS CorporationC CorporationW-2CavitronPiezoLocations/Establishments:UCLAUCSD‍Host: Michael Arias‍Website: The Dental Marketer Join my newsletter: https://thedentalmarketer.lpages.co/newsletter/‍Join this podcast's Facebook Group: The Dental Marketer Society‍‍What You'll Learn in This Episode:Dr. Kalasho's journey from graduate to successful entrepreneur owning multiple dental practices.Understanding contracts and the importance of developing sound business acumen.Insights into partnerships and dental practice acquisitions.Using dental insurance as a financial safeguard while maintaining quality care.Implementing AI in dental practices: from patient care to insurance dealings.The role of tax planning and smart investments in building wealth.Please don't forget to share with us on Instagram when you are listening to the podcast AND if you are really wanting to show us love, then please leave a 5 star review on iTunes! [Click here to leave a review on iTunes]‍p.s. Some links are affiliate links, which means that if you choose to make a purchase, I will earn a commission. This commission comes at no additional cost to you. Please understand that we have experience with these products/ company, and I recommend them because they are helpful and useful, not because of the small commissions we make if you decide to buy something. Please do not spend any money unless you feel you need them or that they will help you with your goals.‍Episode Transcript (Auto-Generated - Please Excuse Errors)Michael: All right. It's time to talk with our featured guest, Dr. Rhonda Kalasho. How's it Rhonda: going? Great. Excellent. I'm in Los Angeles. How can I, how can I fight this weather? We got sun. Michael: I know we got, sun yesterday Rhonda: Yeah. Oh yeah. You're, You're not far. got rain ever. There was car accidents everywhere. Cause nobody knows what to do. Yeah. Car accidents everywhere. Exactly. There's traffic. There's like a little splatter of rain and suddenly we don't have driver's license. Did it rain a lot in San Diego or no?Yeah. It rained a lot. It rained a lot. My parents live out there. I live in Los Angeles, but I mean, we had a lot of rain yesterday, but we love it. I love it. I eat it Michael: up. like a nice change of pace of everything. We all feel like we, what do we do? We got to shut down and everything like Rhonda: that.I'm that person that puts up the Christmas decorations the day after Halloween. So now it matches the weather. Michael: That's awesome. So if you can tell us a little bit about your past, your present, how'd you get to where you are Rhonda: today? Yeah, absolutely. I own, uh, multiple practices under one brand called True Glow Modern Dental.Uh, I did end up owning, uh, an HMO practice straight out of residency, which I loved a lot, but, uh, I ended up, it was a partnership that didn't go well. And it's because I didn't really understand contracts at the time and, So I ended up, uh, just selling my shares of that and then purchasing my first office in Hollywood, in 2018, in 2020 I opened up my, uh, Beverly Hills location and now I'm opening up my Calabasas location. I'm pretty busy right now. I have two little ones at home. But what got me into practice ownership is, uh, I really thought that there was a market deficit in dentistry where it's essentially affordable care, but also at the same time, high quality. and I wanted to utilize some of my business background because I was an undergrad as an undergrad major, I was a business administration, major.And then I picked up some of the prereqs before UCLA to finish up. To get into dental school, but I had a good business acumen before I began my dental journey. And I knew that there was, a really great market for potential of membership style dental offices, which don't operate like an insurance, but more like how you would see traditional memberships, businesses operating where you have a fixed monthly amount, and then you are given, Reduce fees or whatever for a service.And so we were able to do that. Um, I also own my own dental laboratory. So my costs are, fixed in a way where I can produce high quality care, but at the same time, affordably for my patients as well. so we're, uh, kind of a niche brand of dentistry. we do have patients that still come in with insurance.We concierge bill their insurance and the patient gets billed or gets paid directly. Um, that's part of my brand. I just wanted to grow and develop this, business perspective that I had even as an undergrad. and now, lo and behold, I actually really love dentistry. I'm still a wet handed dentist, so I do practice all the time. and you can see that on my Instagram page. I do some, uh, pretty crazy video, full mouth rehab cases. I learned that at my residency, which I did at UCSD. And I recommend everybody actually do a residency. Super important. All my, colleagues and associates that work under our brand have done residencies. that's what got me here. I love. Not only the practice of dentistry, but the business, of dentistry as well. Michael: Nice. Okay. So it's good. Let's rewind a little bit. You said you immediately out of residency, you jumped into practice ownership. You owned HMO. Crazy me. Yeah. Why, Why did you do that?Well, I Rhonda: did go into, office kind of thing a little bit. I did that for like two months and it just didn't fit my style. I wanted certain equipment, I wanted certain things when I would work and it was just the bare bones. I remember being asked to do endo without a rubber dam and without all of a sudden it was just like, I was just kind of.Especially when you're out of dental school you're, you're kind of still into the standard of care and you're really wanting to make sure that you're practicing that as such. And I remember the corporate setting was very much a patient push and making sure that they finish the treatment, make sure that they get the treatment done, make sure that you hit your quotas and all that.And it's all respectable. That's fine. Everybody needs to be aware of numbers, but it became more of less. Quality of and more of just pushing dental treatment out. Um, I quickly ran away from that, but found a great office that I liked a lot. They did accept HMOs and HMO style Cal office. was nice and you can still be very profitable in that market. It's not like you need to be all fee for service to be profitable as a medical or HMO dental practice. It's just a different practice setting. but they're still very profitable practices. And so if people are out there looking at maybe buying in or buying, only a fee for service office.Fee for service offices are incredibly difficult to maintain and hold because as soon as a patient gets insurance, they may leave you, um, as opposed to an insurance based practice, even in the worst times of economic issues But for fee for service, you may find that if you're just collecting free for service, you'll have a lot of waxing and waning of the times and then you'll have these tides of Being really busy and then not being really busy.and that could be really detrimental, but I got into the HMO practice, and then I was offered a partnership, um, because I expressed actually my, my goal of practice ownership. So that's how I got in so quickly. Um, so I, expressed that during my business, meetings with them that I wanted to get involved in as being a practice owner.Um, so I quickly got into that. but the, the way that it was laid out was of course, I just kind of went and read the contract myself. I didn't have a lawyer read it over. I didn't. And so what ended up happening at the end is I put a lot of my own equity in it, but didn't get a good return.and that's a pro, I mean, I always. Call my career as a, constant trajectory of falling forward because I'm constantly making mistakes. And I don't know everything that I'm doing every day. That is a hundred percent. This is the right way of doing it, but a part of building yourself as a professional and an entrepreneur is making mistakes and being okay with that, but you have to learn and learn why it was done and not reproduce the same mistakes.Michael: Interesting. Okay. And it's interesting your, point on fee for service and insurance. I feel like right now, a lot of the practices we're trying to kind of transition out of insurance, right? We're saying, Hey, I want to drop all that because I can't, you know, they're, judging our, work, when we do that.But when it comes to the other way around, how you mentioned it, Hey, if you start off fee for, so what do you recommend Rhonda? lot of the times we want to just start off hitting the ground running fee for service, and a lot of the times. Some people recommend, hey, get some assurances, then slowly drop them off.And then completely go fee for service. Rhonda: Yeah. Absolutely. I think if you build it, they will come depending on how you're going to build it. If you want to build it as a fee for service practice, you may want to just stick to it. It does create a fire under your butt to make sure that you're keeping your practice going.Because if you kind of get into this. The cushion of insurance and insurance does offer cushion, although sometimes we deem them as being, subpar and they're not paying us or reimbursing as well at the end of the day. if it is an 800 crown, if you're taking two hours to do that, yeah, that's.And this is for the new dentists. your, your chair time should be a thousand dollars an hour. If that's what you want to see it as. And that's just basic, right? Like just if you think about how much you're going to have to spend in overhead, dental overhead is incredibly expensive because hygienists get paid a lot.Dental office managers get paid a lot. Dental assistants nowadays, especially in Los Angeles, their average salary is 23 an hour. That's average. So that's a lot. And by the way, they're very accustomed to getting, full benefits. So they do have our, in our practices, they have health insurance, they have gym memberships.They have a lot of stuff that, that is given. 401ks. They have dependents that can get health insurance in our practice. We run it like a corporation and people are very accustomed to that. Even if you're a small dental office, you have to offer these kinds of things. So to that, you have to say that the overhead clearly is very expensive and a lot of your, third party payers, like your dental laboratory is a cost.And the equipment and supplies is also a cost. So yeah, insurance paying you 800 is very low, but if you are, able to do a very nice quality prep, remove all the decay and all that in like 30 minutes, it's not that bad. And that's better than making, not making no money in that time.there is a misconception also that. being really busy means that you are making more money. And those sometimes those HMO practices who are super, super busy, they're pumping out patients left and right. At the end of the day, the fee for service person who saw two patients as opposed to 15 patients is still making the same amount.So it doesn't mean that you have to be very busy, but you just have to create this niche brand or a market for someone to want to pay a fee for service as opposed to going out with insurance. But if you're going to do insurance, a couple things it's good to build the practice, with insurance, if you have nothing there, but if your intention is to drop those insurances, then maybe not sign up for a lot of them because a lot of the times patients will.Leave you as much as you are a great dentist and all of us love to pat ourselves on the backs and they'll go, we're so amazing. No, one's going to leave us, but I'll tell you, they'll leave you so fast. So as soon as you tell them, okay, so your copay is not 300 anymore, you gotta pay 2, 500 for this crown.They're going to run like the wind, right? So like they're going to go to, they'll look to Yelp or something and try to get. Something better, but I'm saying that they're what you have to understand is if you're going to be a fee for service office, you have to provide a service that is very much, reflective of the amount you're asking this person to pay.So you have for every beck and call, you have to offer 24 hour concierge service. You have to talk to them. you have to understand these people, 2, 500 for a lot of people for many people is a lot of money. And that's one crown, right? So if you're going to offer this kind of service to them and your fee for service and not offering any other benefits to them, even if it's payments that you're offering, they are paying this whole dollar amount rather than going through their insurance, which may be paid through their employer.So you have to create your business models are completely different. So you have to be okay with it. You can meet the same bottom line. You can meet the same profits, but when your HMO got to go faster, you got to move faster. You can't just dilly dally, talk to the patients too long, blah, blah, blah. But you also need to treat them like people.It's very important. People also don't want to be treated like cattle, right? they're still paying whatever they're paying for that. So they're going to come in and they want to be respected in the time, but you have to be mindful of your time if you're doing HMO and even PPO.But even PPO insurances don't pay well either, some of them do, some of them pay well, but you still have to. Make sure that you are being aware of you almost have a calculator in your head that your should not be wasted because the overhead is too much and you'll find yourself in a very bad zone your PNL statements where you're seeing your profits kind of dwindle.So just making sure that you're aware of that and speed it up if you're HMO PPO fee for service you can kind of create a little bit more of a pampering effect. Yeah. Michael: Interesting. So then, fee for service, like you said, pampering effect, HMO, or like Medi Cal, right? You'd really, or not Medi Cal, you'd really have to hone in on your efficiency.Oh, yeah, Rhonda: especially when they're first out of dental school, like you got, I remember three hours to do a crown nowhere in private practice is three hours for a crown going to be efficient for anybody, like anybody, not the practice, not the patient. The patient's experience is going to suddenly start to, I remember numbing the patient so many times in dental school because it would fade.I would like, you know, and then they're like, ah, they're constantly moving. It's, It's just, you don't want to. You have to make sure that their experience and what they're feeling in that moment, all that is always in your mind. And this is, that's why dentistry is so hard. You're like a psychologist.You're like a business owner. You're like their friend, but then also their doctor. And then you're sitting with multiple hats and still trying to work. in a kind of a bloody messy environment and work at the millimeter, you know, like, so is a tough job, but it's a, it's also one of the best fields, to be in.Michael: Yeah. Yeah. Interesting. Okay. So then if we fast forward a little bit more, you talked about your partnership, how it did not go well. and you mentioned that you put a lot of equity, but you didn't get a good ROI out of it. Right. Specifically, where did you feel like you missed the mark? Where you're like, yeah, if I would have seen that and you want to kind of give us advice or warn us about that.Rhonda: Yeah. I think I wouldn't, what ended up happening is it was. I was the only one working there. Okay. So there was nobody else there. And so as I was building up this practice and bringing in all the things that I have done for my own brand, I was, buying dental equipment.And leasing it out under my name and doing all this others and not under the corporation and not under the partnership. It was only for me. I was putting in all this dollars, all this money marketing was spent through me. I started my own Instagram page. I started the own Facebook page. I was doing so much and then bringing up this practice and its value.And then when I was, uh, told to. Buy in, I was bought in at the practice value that I brought in. Right. so I put in the money and then bought myself back. Right. And so It didn't work when I got paid out because I got paid out before the money I put in.So it was, I had built it up to what it was and it was just the way that it was laid out. It was really laid out in an unfair way. definitely just kind of taking advantage of a person just. That is maybe not of the nuances of contracts, especially between partners, but just as a pearl to people is that you have to make sure that you have a lawyer reading any agreement that you sign and that they can kind of give you the ins and outs of that and understand that even, you know, you're going to Google and all that kind of stuff.it may be true because especially when you're first out of school, you don't have a lot of money to hire a lawyer or somebody to help you out with that. But even if you have maybe family member that may help you out for your charge to read some of the contracts is going to help. I just got a little, you know, I got a little too pompous and said, Oh, this is, it sounds great.I can have 40 percent ownership and you never get really majority, but, uh, no, I didn't have, I actually had 11%. but I'm saying that sometimes it could be offered You're never really going to be offered a majority. Anybody who owns a practice should not give actually majority.To a colleague or an associate, this is still your baby. This is still your brand and your corporation. you don't want to give a majority because you still want to hold, a lot of the, um, the voting rights and all that would fall ultimately onto you. You don't want your brand to be carried on by someone else, if you want somebody invested.Into your practice because you never wash rental car, right? And you never put glass in a rental car. You kind of just give it to them as all beat up. But if somebody is going to invest in your practice and they've been with you for many years, giving them some sort of equity or practice ownership in the practice itself or in the corporation is actually a great idea. but, uh, they have to also be vested with you, uh, financially and in time, both monetarily and in time. Michael: Okay. Gotcha. Interesting. So then right after that, you decided, all right, let's see, I'm going to start my own thing or were you, you worked for a private, right? You worked for a private practice?I worked for Rhonda: a private practice, uh, for a little bit, maybe like two months. And then I did for like another three, all together, maybe six months after graduating, I, uh, ended up getting into this partnership. but then as soon as my partnership was settled out and I got whatever I could get out of it, I used that money to buy a practice that wasn't doing well at all.It was actually a bankrupt practice, a beautiful location, what I noticed about that practice is they had a really. Robust hygiene department, their patients were coming in regularly. They were seeing about, you know, six patients a day in hygiene and they had four hygiene days. but I noticed the doctor's schedule was dead because the doctor wasn't there.So they had this essentially just a sitting body of water it's like, well, if you have a good hygiene department, there's no reason why a restorative. section of that practice should not be thriving as well because those patients are coming in regularly. You should be doing exams.You should be following up with their care, but they were just coming in for cleanings and then just being off on their way and coming back in another six months. But was no doctor to sometimes even treatment plan them in that day. It's because that just that doctor does. Felt like dentistry was not for them.they didn't like practice ownership at all. And, um, I, at that time had met a broker at a convention at the CDA conference. And he was, uh, like, you know, kind of kept in contact with me, gave me all these, uh, potential offices. This one was just cheap because of its, uh, you know, annual, salary that it was receiving and it's was very low.Or even it wasn't, wasn't good at all, but it was a practice that I could buy relatively dirt cheap. And, but when I got in there, they had carpet, hate carpet in a dental office. If you guys have it, maybe get rid of it, but. it's so gross.Okay. But, but the, the lobby, I remember the chairs are like these dental, these like not dental school. They were like school, like schoolyard chairs. And then they were like propped up by magazines and, um, the front desk person didn't even acknowledge when I walked in there and it was like, just like the walls were blue.It was just like such a. ugly thing. But I, had a vision and I had a goal in mind. I wanted to buy a practice. So this was for all intents and purposes, a great find. It had a great hygiene department. It needed a pick me up. and it's slowly, but surely over the years. And I went from, uh, that office 2018 to 2020 in the middle of a pandemic opening another one.So it's fully doable to ramp up even a shitty practice, but you can still ramp it up if you have the vision in mind there. But so it was considered an acquisition, there's build outs and there's an acquisition. that one was an acquisition because it was still owned by someone.But When I got in there, you have an option of actually keeping on the staff or you can, find new ones, right? Or you don't have to keep everybody on when you actually find yourself on the first day of an acquisition, you present everybody there with a letter. And generally they're not knowledgeable that the practice was even being sold. that's common practice, uh, that. we don't spook people out, right? When sometimes when even patients hear that there is a new practice that's coming in or owner that's coming in, they may leave you're acquiring a practice, a lot of the times they don't inform them until the practice is acquired and then you can send out a bunch of, emails or letters out to the patient and then to the staff.So in my case, when I came in, I was not in love with the staff. I didn't like. That the front person didn't acknowledge that I was there, didn't even look up from her computer. I didn't like that the hygienist, uh, was not using cavitrons or was just basically using prophy cups. It wasn't like scaling or any of that.I ended up just firing everybody and starting fresh. again I had a vision of someone when you walk the room, they're bubbly, they're happy. They are the first introduction to your practice before they even, even on the phone, you can hear them. You know, you want somebody that is going to drive in patients and that.really somber person in the front plays a damper on the mood everywhere. It's like, try to DMV. Do you, everyone look happy? No, it's like you just, everyone's pissed because the person in the front is not the Walmart reader. Like I walk in and I love it. Right. I'm like, yeah, we're here. Okay. Like that's right.Yeah. You're at a shop. Like That's what you want. And what I felt like this is definitely a branding issue. And when you're building a brand, this is stuff that you have to think about. You have to think about the smell. You have to think about the sights. You have to think about the colors.These are all very much, uh, part of even dentistry, because dentistry is a small little business. So you have to know, you can't just pop in with ugly carpet and propped up, uh, chairs. Michael: Yeah, it's interesting that you did that though, because I guess like advise, it's like, yeah, you know, here's the thing.When you do an acquisition, a lot of the times the team may feel betrayed by their original doctor and saying, how come you didn't let us know this, we've been with you forever. We would have understood this. Right. so there's that trust that kind of like deteriorates. Then they kind of start having the fear, like, oh my gosh.Who's this doctor? Who's this young doctor? I know more than her, right? Especially those older office managers. Like they're like, Oh no, no, no, no, sweetie, please can tell you how to do this. Right. And then they try to run it. But letting go everybody at once, how'd you do that? or could you have coached anybody like, cause the hygienist sounded like they were still really good cause they were keeping people on.Rhonda: Yeah. so, for the front person, honestly, I just felt like she didn't even their AR reports cause you do a due diligence on the practice when you're acquiring it their. AR, which is accounts receivable, was very high. So they were collecting zero copay and just kind of letting the person know.I mean, I did, I'll say this, I did give them a chance, right? Like talking to them, um, about maybe collecting copays before the patient comes in, talking about deposits and immediately they shut it down. If someone is not on. your same mindscape and they're not, actually thinking on your level and that they want to build this practice, they're going to be a plague on the practice.So you should immediately just squash it, right? Because if that person is not like. Excited. Oh yeah. There's a new person here with all this energy wants to ramp it up and they're feeling it. They're like, yeah, okay, let's do it. Yeah, we definitely. there, and when you bring up, a report to someone cause I remember sitting next to this, the front office person was also there.It wasn't, she didn't have an office manager. It was a very small skeleton practice. Actually it had no dental assistant. Um, so the person in the front actually, uh, worked as the dental assistant and the person in the front. So I wouldn't say I fired, but everybody, I mean, there wasn't really much of anybody.There was an associate that popped up and did like an OL every 10 months, right? Um, like, which is a. You guys all know dental ever. You're on. Well, like a little tiny filling like every day and then didn't even take out all the amalgam. It was just like, I don't know what the hell I was looking at, but it didn't have a huge, practice.It wasn't like I fired 11 people. I fired three people that were unnecessary. Right. That didn't meet the. And then when I, if I talked to the hygienist and I told, you know, look at the, there are studies on. arrest in their studies on laser. Do you? I'm going to pay for you to take some of these courses. I want you to learn how to do a laser debridement.I want you to use the air polisher or whatever, all these other things that you can provide rather than a prophy cup. Maybe just learn how to scale a little bit, right? Because there's all this plasma this person's tooth. Use the cabotron, use the piezo. And oh, you know, I don't know, you know, I'm really good with this tool and literally how it holds one tool for every surface of the tooth.And it's like, okay, if you're not ready, To change and be part of this, essentially look at where we are now. I had a goal in mind, right? If you weren't ready to hop on my back and I, and fly with me, I'm going to leave you on the ground. You're done. Right? Because then you're going to be a plague on my practice.You're going to be a splinter and I can't move on. Right. I can't get to where I need to be. if you're trying to get from here to there with the same people it's not going to happen. And even when you get to there, you grow, you get more people So my practice has grown significantly from those three people I fired.I now I'm 50 employees deep, right? And every one of them is very much attuned to our mission and our practice philosophy. And we, we really spend a lot of time in making sure that everyone is on the same page. Michael: Okay. So that's interesting. That's really, really good then. So. I know you mentioned that, oh, how long have you been in practice Rhonda: ownership for?Uh, 2018. Michael: How many years? 18, 19, 20, 21, 22, 23, 24, 25. Five? Five years. Five years. Man, how many practices do you have currently? Like working and running? Rhonda: Uh, now three. Yeah. Three. Los Angeles. Los Angeles. No. Oh, well, Beverly Hills. They're all in Los Angeles. So I just stick in this area. Um, they're Hollywood, Beverly Hills, and Calabasas.Jeez. Michael: And that's such a saturated. So how did you do it? Why? here? Like Rhonda: why? I like torture. It's nice. It was, It was terrible. Yes. You said saturated. Absolutely. In my building alone on the same floor, I have four dentists. Michael: Yeah. It was great. So then me ask you, why did you decide to do that? How did you make it grow so much so fast to where you're like, we're three and I think you're on another build out, you said, right?Rhonda: I'm on another build out and then, yeah, I'm on a build out right now. I'm actually in the middle. I got permits for it yesterday, so I'm super excited. So that I have a team that's going to come in and just do our same look. We have a systems always we try to reproduce it and then I have a projection for 2025 is an acquisition.So I'm currently just looking at potential acquisitions as well. Michael: these aren't build outs like ground Rhonda: up. No, they're not The next one is going to be an acquisition because, uh, these buildouts in Los Angeles, the thing is that you can't really own buildings in Los Angeles. They're either grandfathered in, they're incredibly expensive.Like we're not talking about like, I'm sure Nebraska parts of it is expensive, but like, you know, there's some parts like Arkansas, whatever people are going to buy these massive buildings. Right. And that's amazing. I love that. I'm married to this city. Okay. Because I married my husband's out here.My family's out here. I would love to get into more of a less saturated environment. I bet you, I can kill it somewhere else. Right. But I am now getting tortured and killed here, but I've grown to realize, um, what is needed in this kind of market and facilitate a growth.Um, and a lot of it has to do with. front loading, a lot of marketing right off the bat and then getting a good SEO, doing PPC ads, um, doing even mail marketing campaigns. You're kind of just throwing everything out there and then seeing what sticks because a lot of times you may have mail marketing not work out, but in some locations it works out because the demographics still checks her mail in Hollywood.Mail marketing for me does not work. Right. But PPC campaigns and local ad campaigns with Google works out for me, having my, website, really honed in on keywords and all that kind of stuff and having good SEO that's going to manage. the traffic that's coming in is really important for Hollywood for Beverly Hills.There's an older demographic there's a bunch of homes around there. these male marketing campaigns and even being in magazines or whatever it is, those tend to actually work. we still, of course, run our Google. Everybody still uses Google or we're going to, uh, aside that we're talking about other things.Facebook. It's still working with that. Calabasas is the same. These locations are, if they're mostly have homes around you rather than apartments and stuff like that, because I think the apartments, it's a very transient, uh, living situation. You may have some people coming in for a couple of months and leaving mail marketing campaigns don't always work out. these, uh, physical, uh, news articles and whatever it is, may not be working out, but, uh, I also have found, um, being in Hollywood, I was reached out a couple of times by magazines, right? And so like our lure, BBC, MSNBC, I was on Forbes for Hollywood's, they called me the most stylish dentist.I don't know. Okay. But I think it sounds like I was a stylish dentist, but I think they were talking about practice when you were getting into the article, but like the style, the brand was there and it was recognized by Forbes, um, as being a nice office, a nice dental office, and then offering some services to patients that were.Really high tech. But anyhow, we digress on that. But I'm saying that these are some things that I was reached out to. And then my online presence grew because they put me in online articles, right? So they kind of all just fueled each other. And it, and sometimes some people Are not as lucky in that area to find out what works right away.But you want to try different marketing strategies. Um, not every practice is going to feel a good strategy with one as opposed to another. I remember when I was in Orange County. So my first, uh, practice location was up there. HMO one, but That one did really well with like those, but this was a couple of years ago.I don't know, but those apps where you can kind of make your own appointment like ZocDoc and, Oh yeah. Uh huh. Uh huh. Yeah. So they were doing really well there with that. Same with Hollywood because there's are like techie, uh, younger generations, right? Like, so you may want to look, put yourself on one of those platforms where they can get onto your, appointment scheduler and put themselves in there because people don't want to call.Some demographics don't want to call you. Right. And so like there's a younger generation who completely functions a hundred percent on their phone. They emailed a text. They don't even have laptops, right? They're all, everything's on their phone. So even optimizing your website to look good on a cell phone is also incredibly important.You can hop onto different dental offices and you'll see that maybe their website for the phone is not easy. It's like a mess. You have to shrink it really low, move it up this way. It's like, you can't find their number because it hasn't been optimized for mobile. these are some things that you definitely want to look into your practice to make sure that you are marketing to the right group.Who's your demographic that you're trying to aim for? And, uh, what keywords are you using for your SEO? If you're doing primarily Invisalign, where do you rank on the Invisalign when somebody puts Invisalign in? I'm picking on Arkansas. I don't know, but there's a line Arkansas, right?Like I want to go to Arkansas too. Michael: You're like, man. Okay. So that's interesting. When it comes to this, you said you front load a lot at the beginning of marketing. I guess specifically, how much did you front? Rhonda: Yeah. A lot, uh, 15, 000, um, in marketing the first month. Michael: Uh, every month for or just the first month, Rhonda: every month for almost like a year.But now in terms of marketing, we're way past that. We're at like 30, 000. It's still going to grow. It's not going to get smaller, but you have to think about it as your ROI. You're spending that much and you have to think, okay, how much am I spending per patient to come in? if you spent a 15, 000 and let's say that the person, the patient came in and the price on their head was 150, but they came in.And they spent 2000, they spend a thousand, whatever it is, you have to be able to know your, your numbers of the practice and, and be able to decipher if some of those marketing campaigns are helpful. And you have to also make sure you train your staff and be part of your systems to ask the patient, whoever is calling, how did you hear about us?Because that is going to be key for you not to overspend marketing. Oh, Google. Okay. Well, let's put a tick on Google. website referrals. At this juncture, I'm actually now, this is what also people need to understand. You can get really high in marketing, but you don't need to spend that amount every single month.Right? There's some points where you're noticing you're getting 50 new patients. Okay. That's amazing. A month for practice is great. 50 new patients is wonderful. Should I fall back on my marketing? Maybe not. Just don't spend more. Okay. And then what we found is we're getting new patients, but mostly now it's referrals.So I'm actually haven't spent more on marketing in the last year. It's just been kind of the same. So over time, when your brand develops and your practice develops, you may not need to spend this money all the time. You may not need to add more fuel to the fire. it can carry on in itself by creating the environment that a patient will want to come back and see you guys and maybe refer a family member because referrals are above all the best.They are the best. That's why reviews. You always want to make sure your reviews are very good. you really want to get everyone involved and gamify your reviews and gamify your practice so that everybody in the practice is aiming towards making sure that your ratings online is always at its best.and it's because this unfortunately in our society will hurt you the most. And it doesn't matter who you are, what your name is, blah, blah, blah. one time I referred, I know he's an excellent doctor. He's amazing actually. he's on a study club with me and does all this stuff. I was referring him over to someone and I went on his Yelp and I'm like, Oh no. I know. He's really good. What are these on there? Right. And then like, I was like, Oh my God, that's his reviews. And then it makes you even question if this guy is good. Right.And you're like, no, he's awesome. What is that? And then, uh, you know, that's going to make your practice suffer. And it's also going to, uh, definitely create a taste in someone's mouth when they come into your practice that they immediately think you're going to be bad, but have to always maintain those reviews.You always have to put a positive, self out there, even if you're having super crappy day, which a lot of us do, obviously we, this is why also this practice lifestyle is stressful because you can have a crappy day, but you have to walk in and be all smiles. It is good. No one is dying next door. You know, like, Oh, like, you know, you want to be really, I didn't come inand, and give that kind of persona.And it really helps build up those reviews and just make sure that you are constantly also asking for them. You don't want to just assume they're going to leave you a review because the person who's going to leave you the reviews that when you don't want leaving a review, but the person who was like, you guys are awesome.You should ask them. Even as the dentist, I don't know why we think we're above that. We're not above that. This is still, this is your practice, right? this is what you spent your money and your time and your blood and your self, your all that on. And if someone is, saying, wow, and giving you some credence on your practice, they love it.Then ask them, you know, I know it's going to take a lot of time out of your day. I really appreciate if you just do that. Um, if you don't want to, no problem, but I just like, it really helps us out and humble yourself. you should always humble yourself in life and in your practice and in your chair is nothing that glorified you above anybody else.You know, stoop down to always look at the patient when they're talking to you, not at their mouth, but in their eyes. sit at their level. Don't stand above them, bring them up when you're talking to them, not lay them down. You, these, this is never have a opinion of yourself.You certainly just always to just level yourself up with your staff and with your patient. And I parent promise you, these reviews are going to read for themselves because now you are. You're real. you're not fakely asking, Hey, you want to leave us a review?And like you were just a dick to them the whole time. Now you're asking for, right? so make sure you keep up with that the whole time. Michael: Yeah, I like that authenticity, right? So then when it comes to, you mentioned there's something, you do, you have a system that you like to reproduce. When it comes to these practices, what is it? Rhonda: Yeah, so the systems are and they can vary between different offices, but systems it's such a word that's so loaded because a lot of times like we have systems and what does that mean? Right? What is the system? So a systems is. the time a patient calls your office and even before that, how did you get that call?How did that call get intercepted? how did the person answering the phone answer that phone? How are they put into your scheduler? How are they followed up with? These are systems. So the step by step by step by step of getting a patient ultimately in the chair in your office.going over your treatment plan and now appointing them for the treatment because you have to appoint them. You can't just say, I got you in the chair. I did a profi and now you're gone. That's not how you need to reappoint them. an order for that patient to be successful and in your chair and having, and I don't want to, I'm going to just divert a little bit, a patient. value comes from their recare and recall and reemergence of them back into your system. One person comes in and you never see them again. That was not a successful new patient encounter. That patient goes on an inactive list. That patient is essentially Lost. You spent marketing dollars on them.You spent all the time on them. You paid the hygienists to see them. You did saw the assistant. You spent the time with them and it's lost, right? You need to create a systems. where a patient that sits in the chair reappoints themselves for either follow up cleaning or follow up care or whatever it is and stays within your practice, right?And so they stay within your active patient pool. Uh, we consider like active patients, someone who's been at least in within the year or 18 months or whatever it is. So keep mindful of that. This patient needs to be seen for recare. don't call it recall because recall sounds like something's wrong with you, right?So I would recommend that you say recare appointment rather than a recall appointment. and then I give that that's credit to UCLA's Dr. Goldstein practice management class, because I remember that was a, one of the slides on his, uh, I never appreciated that until practice where I remember saying, we'll see you on recall.And then the patient was like, Is it like, wrong, like something is wrong, like it's recalled, like, right? So, like, no, no, we just need to re carry, right? And so it's re carrying, the vocabulary is also important. Anyways, these are all part of systems, right? The vocabulary, the way you speak, the way you point them, the way you follow up with them.And it needs to be laid out. in a way where it's not printed and in a binder and put somewhere collecting dust. Welcome to 2023. Everything is online, right? Everything is online. Choose whatever system you want to do, but make sure it's accessible to everyone and that everybody knows your systems from the front office to the back office.Everyone needs to be aware of the way that your practice runs and how you would handle certain situations. Because once you, as a business owner, Leaves or moves away or whatever not leaves like physically leaves this practice and now comes into a perspective where I'm at where I'm mostly Managing I need to make sure people are aware of how to handle a situation without calling me a hundred times, Michael: right?Yeah, gotcha. So you created this systems how like you just record every single thing you're doing and you're like, what's working? And then pivot To do better and better and better, or? Rhonda: Absolutely. And how many times I've been asked, like, can I have a layout of your manual?And I would say, honestly you need to look at your practice, from a specific, It's, not subjective, it's really objective the way that you should be looking at your, practice. Like, so you need to handle each and every practice needs to be done differently. And so if one thing works in one practice may not work in another, but make sure you are understanding what worked.What marketing tactics worked, uh, how your systems are, the way that you walk a patient to the back, do you have a routing slip, because that's part of our system. Some people don't have routing slips, where it says next visit, where it says when the last cleaning was. These are part of systems.Does a routing slip work for you? Do you want your assistant to write your notes? If they want to write your notes, you have templates for them. These are specific things that may work for practice to practice, but see what works for you and get that written down somewhere. That's accessible. And not only in your head, it needs to be transcribed because it's going to be ultimately in order to scale and not only to scale, you can remain in your own practice, but maybe over a couple of years, add more dental chairs, maybe by the building, whatever it is, you don't have to go into multiple practices.There is some dentists. that are very near and dear to me, which I love, and they're killing it with one practice, giant location, like one location. It's huge. Right there. They see as many patients as I do, but just in one location. And so they've scaled. their practice, their one practice to an extraordinary size and they have, worked their systems to what works for them.Michael: Gotcha. Interesting. Okay. So then the systems is tailored to like the practice, obviously, right. But at the same time. I guess it's more like we have to start documenting everything right now and then kind of continue to pivot and pivot. Yeah. Rhonda: There's a lot of like, HubSpot may have something, but like also there's something called training all that also has like an online app, um, that you can do.There's a lot of sites that you can actually create, uh, like leaderboards. For your practice, and that's really good because you can put quizzes on there, like when you're training someone, how do you train them? Do you physically have to train them? Like, because some people learn differently, you may need to, um, Train them, physically show them, show them pictures, show them video, and then maybe take a quiz at the end, like, you know, so yeah, there is a lot of systems that you can look into that may fit your practice, different pricing and all that kind of stuff, but I would recommend is online stuff, app, you can even right now, you can find a bunch of developers that can develop stuff just for you. I utilize a lot of AI in my practice. and, with the development of AI, I've utilized AI where a lot of people have never even thought to use AI, but I've gotten people who develop AI to specifically build stuff for my practice that I think that has helped. I've paid them out and it's just mine. It's not anybody else's. You can't actually go buy it, but I thought this is what I need. And with the cloud based systems, like, so I used to have All my practices were on a server and we were using, but they're now cloud based systems, like, I'll use a different word besides systems but practice management systems, So practice management systems, sometimes it used to be on a server. Now you'll find a lot of them on the cloud. The cloud based servers are a lot better because you can really build. softwares within them that can function for your practice and specifically for them. And you can get the coding and all that kind of stuff.You can find them on like squad help or whatever. Um, but you'll, you can find people who are really good in development and build stuff for your practice. Um, and then that goes into even apps. Maybe you can make an app for all your videos and your, web, information, like your employee handbook and stuff can be on there too.Michael: What have you created with, so far Rhonda: for your practice? So far I have a robot that calls all the dental insurances that are, because we're out of network and we still have concierge dental. So the concierge style. So even if they have dental insurance, we tell them, sure we'll get a breakdown for you and send it out.Ri

The Nobel Prize winner talks about PIEZO 1 and 2, proprioception and the viral photo of him and his son from the 2021 Nobel Prize announcement.

The Nobel Prize winner talks about PIEZO 1 and 2, proprioception and the viral photo of him and his son from the 2021 Nobel Prize announcement.

JP's Product Pick of the Week 10/24/23 Piezo Driver Amp PAM8904 https://www.adafruit.com/product/5791 Visit the Adafruit shop online - http://www.adafruit.com ----------------------------------------- LIVE CHAT IS HERE! http://adafru.it/discord Subscribe to Adafruit on YouTube: http://adafru.it/subscribe New tutorials on the Adafruit Learning System: http://learn.adafruit.com/ -----------------------------------------

This week on the Great Search, we're taking apart a McDonalds McNugget Tetris game (https://tetris.wiki/Tetris_(McDonald%27s)) given away in China for the 40th anniversary of the chicken mcnugget. Unsurprisingly, it's an epoxy blob'd chip that does just about everything! For the background music, a disc piezo is used to make the beeps. We've covered magnetic buzzers before (https://blog.adafruit.com/2020/11/24/the-great-search-piezo-and-magnetic-buzzers-thegreatsearch-digikey-digikey-adafruit/) on the Great Search, which we use on some of our design for SMT tone-making. At a 500K build, budget is going to be the most important concern, so instead, we can go for a ultra low cost piezo disc! Let's take a look at what is available at DigiKey and the differences between magnetic and piezo buzzers. See the chosen part on DigiKey https://www.digikey.com/short/dtbmq7jm

Dropping another edition of their sonic sedition, El Educador flexes Latin, Ed2000 favours new and emerging sounds. Adept and Initiate give hints and clues. As yet undefined becoming, the future sound of possible futures. New fusions with Ltj Bukem, Yuna, Lxury, Piezo, Eladio Carion, El ALfa, King Mzaiza, Josh Wink. This is Dub Intervention!Tune into new broadcasts of Dub Intervention, Saturday from 8 - 10 PM EST / 1 - 3 AM GMT (Sunday).For more info visit: https://thefaceradio.com/dub-intervention///Dig this show? Please consider supporting The Face Radio: http://support.thefaceradio.com Support The Face Radio with PatreonSupport this show http://supporter.acast.com/thefaceradio. Join the family at https://plus.acast.com/s/thefaceradio. Hosted on Acast. See acast.com/privacy for more information.

Today on Holistic Dentistry, we help you determine if you need a tooth extraction and the steps you can take for a healthy recovery. In our office, we do everything we can to avoid tooth removal. Although, in cases of severe cracking and deep tooth decay, an extraction is unavoidable.    In this episode, we take you step by step through the extraction process and introduce you to a cutting-edge tool capable of gently removing teeth without causing soft tissue damage. No pliers or drills are required because the Piezo device utilizes ultrasonic technology and vibration to carefully remove the tooth without affecting the adjacent teeth, bones, nerves, or gums.    Many patients wonder if they need antibiotics after an extraction. The truth is that it depends, but most extractions do not require antibiotics. You can never sterilize the mouth, but Ozone therapy detoxifies your mouth throughout your procedure, lessening the need for harsh antibiotics. We review severe cases that require antibiotics and give you the knowledge to advocate for an antibiotic-free recovery. Join us to learn more about the extraction process.   Key Takeaways: [1:45] Why You Need a Tooth Extraction [5:30] The Anatomy of Your Tooth  [7:00] Removing Each Individual Root  [8:00] Ask Your Doctor to Use A Piezo Device  [9:00] Detoxifying The Mouth During Your Procedure  [11:00] Why Bone Grafts Delay Healing  [15:45] When You Need Antibiotics  [18:00] Placing an Implant During an Extraction   Want to know more about tooth extractions in our office? https://www.beverlyhillsdentalhealth.com/teeth-extraction-beverly-hills-ca/   Get in contact with one of my offices https://www.beverlyhillsdentalhealth.com/contact-us/     Resources: BeverlyHillsDentalHealth.com |  Instagram  DrSandaMoldovan.com | Instagram  Orasana.com | Instagram  Orasana Water Jet Heal Up! IAOMT.org  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.03.535302v1?rss=1 Authors: Griffin, M., Talbott, H., Guardino, N., Guo, J., Spielman, A., Chen, K., Mascharak, S., Parker, J., Henn, D., Liang, N., King, M., Cotterell, A., Bauer-Rowe, K., Abbas, D., Deleon, N. M. D., Fahy, E., Sivaraj, D., Downer, M., Akras, D., Berry, C., Cook, J., Quarto, N., Klein, O. D., Lorenz, P., Gurtner, G., Januszyk, M., Wan, D. C., Longaker, M. T. Abstract: While past studies have suggested that plasticity exists between dermal fibroblasts and adipocytes, it remains unknown whether fat actively contributes to fibrosis in scarring. We show that adipocytes convert to scar-forming fibroblasts in response to Piezo-mediated mechanosensing to drive wound fibrosis. We establish that mechanics alone are sufficient to drive adipocyte-to-fibroblast conversion. By leveraging clonal-lineage-tracing in combination with scRNA-seq, Visium, and CODEX, we define a mechanically naive fibroblast-subpopulation that represents a transcriptionally intermediate state between adipocytes and scar-fibroblasts. Finally, we show that Piezo1 or Piezo2-inhibition yields regenerative healing by preventing adipocytes activation to fibroblasts, in both mouse-wounds and a novel human-xenograft-wound model. Importantly, Piezo1-inhibition induced wound regeneration even in pre-existing established scars, a finding that suggests a role for adipocyte-to-fibroblast transition in wound remodeling, the least-understood phase of wound healing. Adipocyte-to-fibroblast transition may thus represent a therapeutic target for minimizing fibrosis via Piezo-inhibition in organs where fat contributes to fibrosis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.12.523838v1?rss=1 Authors: Ventrella, R., Kim, S. K., Sheridan, J., Grata, A. C., Bresteau, E., Hassan, O. A., Suva, E. E., Walentek, P., Mitchell, B. Abstract: Xenopus embryos are covered with a complex epithelium containing numerous multiciliated cells (MCCs). During late stage development there is a dramatic remodeling of the epithelium that involves the complete loss of MCCs. Cell extrusion is a well-characterized process for driving cell loss while maintaining epithelial barrier function. Normal cell extrusion is typically unidirectional whereas bidirectional extrusion is often associated with disease (e.g. cancer). We describe two distinct mechanisms for MCC extrusion, a basal extrusion driven by Notch signaling and an apical extrusion driven by Piezo1. Early in the process there is a strong bias towards basal extrusion, but as development continues there is a shift towards apical extrusion. Importantly, receptivity to the Notch signal is age-dependent and governed by the maintenance of the MCC transcriptional program such that extension of this program is protective against cell loss. In contrast, later apical extrusion is regulated by Piezo 1 such that premature activation of Piezo 1 leads to early extrusion while blocking Piezo 1 leads to MCC maintenance. Distinct mechanisms for MCC loss underlie the importance of their removal during epithelial remodeling. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this week's episode, we'll discuss new research revealing that the mechanosensory ion channel Piezo1 is the elusive carrier molecule of the Er blood group antigens, thus establishing a new blood group system. Next, we review results of a randomized phase 3 trial of enasidenib versus conventional treatment in late-stage mutant-IDH2 relapsed or refractory AML. Although the primary endpoint of overall survival was not met, investigators say the risk benefit ratio remains positive. Finally, we'll review a study showing a clinically significant risk of breakthrough COVID-19 infections in patients with B-cell malignancies despite vaccination and pre-exposure prophylaxis with tixagevimab-cilgavimab during the Omicron era. However, hospitalization rates in the study were low and no deaths were reported.

Episode 610: January 1, 2023 playlist: big blood, "Weird Road pt. II" (Weird Road ep) 2022 dontrustheruin Minami Deutsch, "Steller Waffle" (Fortune Goodies) 2022 Guruguru Brain Fort Romeau, "Every Man Has Your Voice" (Every Man Has Your Voice (single)) 2022 Cin Cin Amp, "AdieuSirene" (ECHOESFROMTHEHOLOCENE) 2022 self-released Ura, "Let The VST Cry For You" (Baby With A Halo) 2022 Motion Ward Piezo, "Xxx^_^x" (LSD Superhero) 2022 Wisdom Teeth DECIUS, "Bitch Tracker II" (Decius Vol. I) 2022 The Leaf Label Esau, "Osaka" (Other Places) 2022 self-released Michael Lightborne, "Black water" (Sli na Firinne) 2022 The Department of Energy jesu, "piety" (pity / piety) 2022 Avalanche Email podcast at brainwashed dot com to say who you are; what you like; what you want to hear; share pictures for the podcast of where you're from, your computer or MP3 player with or without the Brainwashed Podcast Playing; and win free music! We have no tracking information, no idea who's listening to these things so the more feedback that comes in, the more frequent podcasts will come. You will not be put on any spam list and your information will remain completely private and not farmed out to a third party. Thanks for your attention and thanks for listening.

On episode 390 of Geekiest Show Ever, Elisa and Melissa share some hardware, app and tv picks to entertain your inner geek over the holiday break. Melissa reviews her new Philips hue smart plug and shares how she's used it to upgrade her tv. She also reviews Chill Zones, SYC PRO, and Piezo apps. Check out our full show notes here https://www.geekiestshowever.com/gse390-holiday-break-entertainment/ Do you have questions about what you heard in this episode? Please send us your feedback. You can email us: podcast at geekiestshowever dot com. Follow us on Twitter for additional tips and conversation: https://twitter.com/GeekiestShow. We'd like to hear from you, so let us know which tech topics interest you most. Elisa can be found at https://twitter.com/elisapacelli1 and Melissa can be found at https://TheMacMommy.com/ Show Us Some Love Melissa loves her eufy cameras. If you decide to purchase a eufy camera, use Melissa's referral link: https://fbuy.io/eufyus/zp85rwa3 Thinking of switching to Mint Mobile? Use our refer-a-friend links: Elisa's is http://fbuy.me/tSm4x and Melissa's is http://fbuy.me/tRqgc Do you like getting cash back on purchases? Use our Rakuten referral links: Melissa's is https://www.rakuten.com/r/MELISS95892 and Elisa's is: https://www.rakuten.com/r/SENSEI13 Geekiest Show Ever is an independent publication and has not been authorized, sponsored, or otherwise approved by Apple Inc. Products made by Apple mentioned in this podcast are a trademark of Apple Inc., registered in the U.S. and other countries and regions.

In this episode of the Fret Files Podcast, Eric goes over some of the contents of his new book, "Solid Sound." Then comes listener submitted questions, including questions about grounding volume pots, adding a volume control to a Piezo pickup, de-glossing guitar necks, the P-13 pickups and flipping magnets over to get an out-of-phase sound, and a discussion about the different eras of Fender guitars.

Piezo通道是介导人类触觉感知的重要蛋白, 它的发现者Ardem Patapoutian也因此被授予了2021年的诺贝尔生理学和医学奖（与David Julius分享）。这期我们请到了解析piezo2 蛋白结构的两位研究者周珩和王莉做客我们的播客。我们除了聊到课题的方法和结论，也聊到了他们两位在合作推进这个课题时的压力，挣扎，坚持和课题突破时的喜悦，希望他们的感悟能给每一位正在课题中挣扎的研究者安慰和勇气。下面是播客大纲，大家可以点击时间点跳转到想听的话题Part I 关于piezo2的课题和冷冻电镜04:15 piezo通道有很重要的生理和病理学意义10:46 王莉接手了一个好几个人尝试了又放弃了的课题。15:22 piezo2在蛋白纯化方面的重重困难20:27 科普冷冻电镜解析蛋白结构的原理简介，在piezo2课题中的应用以及遇到的困难29:04 周珩因为建模型累出了鼠标手，但是成就感满满。31:02 两个强迫症患者为课题共同付出了很多，彼此支持和鼓励。35:19 课题那么困难，王莉为什么一直相信它能做出来呢？40:15 王莉跟周珩在合作过程中充满了摩擦和争吵 （十分搞笑）56:27 结构生物学为什么总发顶刊，是不是在灌水？Part II 聊聊挫折和人生68:28 王莉聊了聊自己不太顺利的求学和科研之路，但是依然坚持75:32 学霸周珩是如何走上科研道路的，他们为什么爱科研80:42 王莉聊自己在科研过程中的suffer和struggle，这些都成了她的财富（必听）85:17 王莉和周珩为什么在人生不顺利的时候还能自信的勇往直前 （必听）95:03 漂亮的王莉为什么一直单身？100:20 趣事儿：周珩范了一个巨尴尬的错误，大家笑翻了105:37 给听友们的寄语精美的三叶桨结构的piezo2结构 (Wang et al., Nature, 2019)Piezo2 文章链接

Uppvärmning/uppföljning Premiär för Jockes podd-iMac. Jocke försöker spela in, Christian och Fredrik diskuterar billig öl Har Jocke fått sin bil ännu? Sommaren är tillbaka? Ämnen Basic Apple Guys läsare har röstat fram tidernas bästa Mac-os-standardskrivbordsbild. Vinner rätt låt? Vilka är panelens favoriter? Fredrik har skaffat Macbook air M2, har tidiga intryck av bland annat flyttassistenten En blå Homepod mini DMZ Retro #6 kommer att komma. Mer information kommer i sinom tid via alla rimliga kanaler Film & TV The Meg. Å dra åt helvete. 1/5 BMÅ (J) Sandman. Fredrik har sett. 4,5/5 (F) Poddtips: Emanuels Karlstens och Anne-Marie Eklunds Löwinders sommarprat. Länkar Jockes podd-Imac Piezo Du har ingen surf Flat tire Restaurang Tjuren Activesync Omröstning om tidernas bästa Macos-standardskrivbordsbild 512 pixels har alla Mac OS-skrivbord uppskalade till moderna upplösningar Macbook air M2 Apples flyttassistent Displaylink Basic Apple guys omdesign av appen Kontakter The Meg Megalodon Marianergraven The sandman - TV-serien The sandman - den tecknade serien Being Flynn She-hulk Podd-tips: Emanuels Karlstens och Anne-Marie Eklunds Löwinders sommarprat ICANN Nyckeln till internet Internet hall of fame DNSSEC Fullständig avsnittsinformation finns här: https://www.bjoremanmelin.se/podcast/avsnitt-320-grisens-hemlighet.html

Uppföljning/uppvärmning Kompisar låter inte kompisar köpa, grilla eller äta Denniskorvar Macpro och Jekyll: vad problemet egentligen var Skärmdrama, del 5 När folk utan datorintresse skaffar nya datorer Jockes Apple TV-fjärr löpte amok Ämnen Arc – en annan sorts webbläsare. Christian har testat och förklarar vad som är nytt och spännande Jocke köper “uppkopplade” fläktar… … och installerar homebridge. Film & TV Eftersom Westworld S04 har börjat så har Jocke sett om S01-S03. Retrospektiv Wind river: film med Jeremy Renner och Elizabeth Olsen på SVT Play. 4/5 BMÅ Jett: pang-pang-serie på HBO max med Carla Gugiano. Lite ojämnt manus och regi men överlag bra underhållning. 3/5 BMÅ The Terminal List: action thriller med Chris Pratt. Säsong 1 på Amazon Prime diskuteras grundligt. (C: 3,5/5 BMÅ, J: 3,5/5 BMÅ) Länkar Piezo Jezper från En podd om teknik var med i förra avsnittet Scan hotdog aka Denniskorv Dennis - seriekaraktären Movable type Lanyon-temat Simply Static Wordpress Plugin Hem-PC Jockes 4K skärm Switchresx Apple skickar ut uppdatering för Apple tv-fjärr The Browser Company - Arc Spark Omniweb Jockes uppkopplade fläktar Homebridge Westworld (Imdb) Avsnitt 57 Avsnitt 63 Wind river Jett (Imdb) The Terminal List (Imdb) Fullständig avsnittsinformation finns här: https://www.bjoremanmelin.se/podcast/avsnitt-316-slutet-pa-musmattan.html

After last week's podcast saw artists stretching out the length of their tracks, this week's sees some of the world's most exciting independent artists consolidating into shorter tracks of delight. From the gabber of Lady Neptune, to the sound art of Chrome Hoof's Chlöe Herrington, via the futuristic jazz of Polish five-piece EABS, there's a lot to love in relatively small pieces. Elsewhere we have a masterful release from Kenyan sound artist KMRU, reissued proto Japanese funk, phenomenal metal-cum-psych of Friend, and much more Tracklisting Minoru “Hoodoo” Fushimi – In Praise of Mitochondria (180g, France) KMRU & Aho Ssan – Rebirth (Subtext Recordings, UK) EABS – Lucifer (The New Sun) (Astigmatic Records, UK) Friend – International Top Bloke (Human Worth, UK) Chlöe Herrington – Ajar (self-release, UK) Lady Neptune – Time 2 Make U Feel Good (Night School, UK) C.V.E. – Thugs and Clips (Nyege Nyege Tapes, Uganda) Korubu – Roads (Locomotiv Records, Italy) Piezo – TB2 (with K-LONE) (Wisdom Teeth, UK) Oren Ambarchi, Johan Berthling, Andreas Weliin – IV (Drag City, USA) This week's episode is sponsored by The state51 Conspiracy, a creative hub for music. Head to state51.com to find releases by JK Flesh vs Gnod, Steve Jansen, MrUnderwSood, Wire, Ghost Box, Lo Recordings, Subtext Records and many more Produced and edited by Nick McCorriston.

Uppföljning/uppvärmming Christian kommer direkt från Teams, Jocke har inte Jira. Alla behöver en Nicklas Det har snöat en del. Skräckhistorier och längtan efter en XC70 igen. Man kanske borde julhandla? Jocke får lov av övriga deltagare Ett semmelutrop till lyssnare i trakten av Stockholm och Uppsala Mer tangentbord: Christian beställer Varmilo VA88Mac TKL. Jocke hittar sitt Logitech K750. Alla har det kul med adaptrar Christian har myggbekymmer, byter skrivbordsbakgrund Mer post-covid: Silly predictions från Koos Looijestiejn Christian och Jocke avslutar OS mitt i natten. Blir det Tornado som abstinenshantering framöver? Ämnen Jocke hittar foto på sin dator från 2011. Fredrik och Christian zoomar in på dockan och myser. Hur använder vi den? Fyller den sina syften? Kan den bli bättre? Mac mini m1: superdatorn. Jocke avvecklar sin gamla mac mini, etc. Film och TV War of the Worlds. SE01 & 2. Disney+. 3/5BMÅ The King's Man. 3,5/5BMÅ (J) 2,5/5 BMÅ (C) Beck - 58 minuter. 3/5BMÅ (J) (det blir mindre och mindre Beck i den här serien…). Fyra “avsnitt” till är tydligen beställda. Länkar Gitlab BetterGeo Semmelburgaren Christians bloggpost om storebror Varmilo VA109 Mac Varmilo VA88Mac Cherry MX brown - fokuserad och märkbar Gazzew boba U4 - Fredriks “tysta taktila” switchar Toughbook Ingemar Johansson Chipmem och fastmem Logiteck K750 Day 708—Silly predictions /r/antiwork Jockes desktop, våren 2011 Front and center Quicksilver OS/2 Warp desktop Openstep 4.2 BeOS 5 Solaris 8 med CDE Dock - macOS Piezo War of the Worlds Jeff Wayne's the war of the worlds Jeff Wayne's the war of the worlds - spelet från 1998 The King's Man Beck - 58 minuter Git-repot för filmarkivet Fullständig avsnittsinformation finns här: https://www.bjoremanmelin.se/podcast/avsnitt-297-alla-behover-en-nicklas.html

Article: Plant PIEZO homologs modulate vacuole morphology during tip growth Journal: Science Year: 2021 Guest: Ivan Radin Host: Arif Ashraf Molecular Plant Editorial highlight: Evolutionarily conserved mechanosensor PIEZO in land plants Abstract In animals, PIEZOs are plasma membrane–localized cation channels involved in diverse mechanosensory processes. We investigated PIEZO function in tip-growing cells in the moss Physcomitrium patens and the flowering plant Arabidopsis thaliana. PpPIEZO1 and PpPIEZO2 redundantly contribute to the normal growth, size, and cytoplasmic calcium oscillations of caulonemal cells. Both PpPIEZO1 and PpPIEZO2 localized to vacuolar membranes. Loss-of-function, gain-of-function, and overexpression mutants revealed that moss PIEZO homologs promote increased complexity of vacuolar membranes through tubulation, internalization, and/or fission. Arabidopsis PIEZO1 also localized to the tonoplast and is required for vacuole tubulation in the tips of pollen tubes. We propose that in plant cells the tonoplast has more freedom of movement than the plasma membrane, making it a more effective location for mechanosensory proteins. --- Send in a voice message: https://anchor.fm/no-time-to-read-podcast/message

Updates 00:11:24 Sold the vox, bought the D20 (stab: Mathews The Architect) Fender Acoustasonic Telecaster MIM (stab: EHX super pulsar) 00:25:46 This is probably the one you want Now made in Mexico and part of the Player series Fewer features, but also $800 cheaper Apparently these are really taking off So with the lower price comes some cost saving measures like a non-rechargeable battery (9V), 3-way selector instead of 5 (fewer sound options), different Piezo system Pedal Genie 00:38:19 Strymon Riverside $300 Hamstead Subspace $288 Suggestion of the week 01:04:32 Get back sessions https://www.disneyplus.com/series/the-beatles-get-back/7DcWEeWVqrkE Can't Swim - Set the room ablaze (song) Thank you to our Patreon supporters! Carson Ricketts Nick Greenwood Timmy S. Matthew Fenselau (pronounced fence-law) Riesenwolf! Jamie Evans Jeffrey Wright Doug King Doug Gann Righteous Ryan Johnson Steve Huffman Jonas Sabatini Eric Girabaldi Andrew Walsh from Andrew's Alcove OG Friend of the show Brian Rizzi Doug Christ of Thirty7 FX Sean Wright of Lollygagger FX Brian Gower and Kyle McIntyre of The Tone Jerks Podcast --- Send in a voice message: https://anchor.fm/thetonecontrol/message

Autor: Winkelheide, Martin Sendung: Forschung aktuell Hören bis: 19.01.2038 04:14

Mit dieser Episode findet sich ein weiterer Teil der Reihe über die Themen des Medizinstudiums. Werbung Bücher auf Amazon finden sich unter https://amzn.to/3gjEMvY --- Send in a voice message: https://anchor.fm/selbstorientiert/message

Discover how you can balance your Chakras and help others do the same with specially created sounds created by composer, musician, and Chakra Balancing expert Ty Ford.See Timestamps BelowWhether you're simply curious about Chakra Balancing or you're a longtime advocate or practitioner, by listening to this conversation with musician, composer, and Chakra Balancing expert Ty Ford, you'll discover:- Exactly what Chakra Balancing is;- How it works, and how you can benefit; and,- How you can use a special system of Soundscapes to balance your Chakras and promote energetic wellbeing simply by listening to the frequencies embedded in the audio sounds.Ty Ford is a musician, composer, audio engineer, and a member of the Maryland Entertainment Hall of Fame. He is also a caring Energy Practitioner who has extensive training and experience helping clients using Chakra Balancing, Qigong, and other methods.You'll hear how Ty discovered the exact frequencies that align with each of your seven Chakras and then incorporated those frequencies into special Soundscapes designed to resonate with and tune each Chakra.Timestamps:00:00 - Episode topic;00:32 - Podcast, host, and guest info;02:29 - What is Chakra Balancing?;04:56 - Combining Chakra Balancing & Qigong;06:55 - What does a client experience?;09:35 - How is Qigong applied?;10:36 - How Chakra Soundscapes came to be;16:34 - How to contact Ty to learn about Soundscapes;17:40 - How to listen free online;18:46 - How Soundscapes are being used;19:15 - Ty demos Soundscapes at Edgar Cayce Institute in N.Y.;21:22 - Gentleman's experience who had M.S.;23:37 - Magic of Microtones;24:35 - How to contact Ty Ford;24:54 - Help Ty learn about the Primo Vascular System;—Featured Resources:Ty Ford's website: https://www.TyFord.com;Ty's email address: TyFord@TyFord.com;Website where you can listen at no cost to sample Soundscape audios: https://tyford.bandcamp.com/.YouTube video where you can watch the conversation with Ty Ford: https://youtu.be/b3ULamwd7Ow—Host: Stephen Carter, CEO, Stress Solutions, LLC.Website: https://www.EFT-MD.com;Email: CarterMethod@gmail.comProgram Note: During Ty's discussion about learning Medical Qigong, he shared information about studying with Michael Peng. His instructor's name is Robert Peng, not Michael. Robert Peng is an internationally respected Qigong teacher.—Technical Information:Video recorded with Zoom. The audio file used to prepare this podcast was recorded with Piezo 2. Initial editing done with Audacity, leveled with Levelator, with final edits and rendering done using Hindenburg Journalist Pro.Microphones: EV RE320 for video intro and interview. Shure SM58 for audio podcast intro.—Keywords:chakra, chakra balancing, Ty Ford, qigong, energy healing, Rosalyn Bruyere, Robert Peng, microtones, emotional healing, chakra frequencies, chakra sounds, primo vascular system, chi gong, healing,

There once was a bull that had a microchip inserted into its brain. as it rushed the Matador the chip was activated, and the bull froze in his tracks. Imagine…Continue readingDTR S6 EP 591: Piezo Puppets

Subject Index00:00 Intro02:20 Grounding issue with hollow-body and bridge06:30 Will the new Epiphone headstock hurt the value of the old Epiphone guitars12:23 Will hand sanitizer hurt electronics or finishes on guitars?16:00 The new Alex Lifeson Epiphone guitar with Piezo.23:16 Parking your money in guitars?28:20 No Harley Benton guitars on my wall?32:32 any plans to review the Sire T style guitar?35:55 The PRS Mira and Mira X?41:30 The issues with Fender in the last couple yearshttps://www.youtube.com/watch?v=XJNrG2iqBO448: 33 Have I used any Warmoth necks or bodies?50:28  shout out to Nikki Lovesey51:21  What gauge and type of wire do I use to wire up guitars?1:00:40 Shout to Loud and Clear music1:07:50 Louder amps are cheaper than quieter amps now?1:10:58 PRS SE 24/08 or PRS SE Pauls guitar?1:13:00 Hissing in your electronics?1:16:05 What is my favorite guitar pick?Links o the picks I useHerco Picks? ( The picks I use)https://imp.i114863.net/QMJXMDava picks1:24:58   Why no Jacksons?1:27:28 What is my favorite Kiesel model?1:28:50 Did You Miss Out Not Selling Your Guitars During The Pandemic?1:31:00 Sweetwater sent out a email saying prices are going up?1:35:20 Why your Sweetwater rep might not be calling you as much?1:43:45 is 15 watts Tube loud enough to gig with?1:51:01 If you give me bad feedback on a product they are never on the channel again1:55:48 What You Tuber has my favorite signature product?1:58:10  Why I didn't keep the King Of Tone pedal2:01:45  Gibson is the Jason Voorhees of the guitar world. The Icon Market2:06:43 My reaction video to rig run downhttps://www.youtube.com/watch?v=fd66mec2gIQ2:2:10:30 The $1215 Gibson guitar case???2:12:22  The PRS CE24 or the Gibson LP Lite?2:18:40  The steps I take to find the spot where guitar doesn't buzzThe KYG merch was pulled down for a week for updates. Its back nowhttps://teespring.com/stores/know-your-gear-shop-2You can become a Patreon and support more videos like this, Plus see videos before they come out and typically a longer version of that video as wellhttps://www.patreon.com/homeNEW 2021 Duck Walk and GoldTop logo shirts https://teespring.com/stores/know-your-gear-shop-2Here are some other products from a dealer I trust and buy from onlinehttps://imp.i114863.net/c/2224555/791999/11319Send photos of you in your shirt here. askknowyourgear@gmail.comPODCASThttps://knowyourgear.buzzsprout.comSupport the show (https://www.patreon.com/phillipmcknightKYG)

Innovative tech often defined by either the hardware or the software. In the last few years it seems like the big names in tech are being driven by the software they develop often looking like SaaS. While software and apps can be trendy its typically the changes in hardware partnered with software that brings systemic changes in our lives.Now a lot of that tech is experienced in our daily lives without truly knowing how it works or all the pieces that bring it together. Today's guest Todd Eckler is the Chief Revenue Officer of Piezo Motion. Their pumps and engines are impacting a wide range of sectors including robotics, avionics and aeronautics, med-tech, smart homes, drones, and beyond. Not only is Piezo Motion creating incredible tech, they are partnering with world changing organizations to implement these piezo technologies in precise tools.Throughout the conversation we discuss the research and development process, what piezo technology does and where it is found, identifying and building the right opportunities, how strategic partnerships are significant for your business growth, why precision matters, and much more.If you think this technology is only impacting high tech, you would be surprised to learn that it impacts your own life. Piezo technology can be found in your grill, acoustic guitar pickups, and much more. So join us as we dive deep into an overlooked and often unknown world of tech hardware.LinksPiezo Motion Website: https://piezomotion.com

Find your flex piezo at Adafruit: https://www.adafruit.com/product/4931 Did you know they make pliable #piezo sensors? Time to put them to good use. #adafruit #collinslabnotes #piezoelectric Visit the Adafruit shop online - http://www.adafruit.com ----------------------------------------- LIVE CHAT IS HERE! http://adafru.it/discord Adafruit on Instagram: https://www.instagram.com/adafruit Subscribe to Adafruit on YouTube: http://adafru.it/subscribe New tutorials on the Adafruit Learning System: http://learn.adafruit.com/ -----------------------------------------

Recorded 29th March 2020 You may notice some difference in the sound this episode - Simon's Mac had a kernel panic right at the end of the show and wiped out his recordings... Luckily Nick records a backup but his set up is a simpler Piezo recording with no Audio Hijack wizardry. However without him there'd have been no show at all. So we aren't complaining. Also we need to get Jim a mic that doesn't “rustle”! This week news of any great consequence (well non COVID-19 news anyway) was a bit thin, but as we're all in lockdown guests weren't! In a bit of a houseparty Simon is joined by Nick Riley, James “MacJim” Ormiston, special guest Ronnie Lutes and eventually Donny Yankellow... to make a fist of what they could dig up to chew over. And the amazingly brilliant interlude is "stolen" from Daniel Matarazzo (bit.ly/AwfulVirus) GIVEAWAYS & OFFERS Glenn's book is completely FREE and can be downloaded here You can get Ghostery Midnight free for 3 months with the coupon code ‘workathome' Steve over at Geeks Corner is having an Apple Watch Strap giveaway... Why not pop on over and enter and get the chance to win an AppleWatch strap of your choice? Serif have made all their Affinity apps on Mac/PC and iOS available on a 3 MONTH free trial and reduced the priced by 50%... If you were even remotely interested now is the time to try and buy! Why not come and join the Slack community? You can now just click on this Slackroom Link to sign up and join in the chatter! Slacker @MacJim has a family friendly Flickr group for listeners to share photos because the Darkroom channel in the Slack has become so popular - if you're interested head over to to the Essential Apple Flickr and request an invitation. On this week's show: NICK RILEY @spligosh on Twitter very occasionally. Sometimes appears on Bart Busschots' Let's Talk Apple JAMES ORMISTON MacJim in the Slack In charge of the Essential Apple Flickr Also on Flickr as thesrpspaintshop DONNY YANKELLOW AarcadeReviews.com for apple arcade reviews and more @rtteachr on Twitter Find his work at hedgehogalley.com Find his stuff in iBooks, a load of sticker packs in the App Store under Donny Yankellow and DesignBundles.net as Skrbly Skrbly Studio on YouTube Skrbly Store Skrbly Studio (Anyone can Draw) – App Store Kiddims on Graphite Comics Life is Random on Graphite Comics Search for Yankellow on the App Store/Books for Stickers and other work RONNIE LUTES @Nevadicus on Twitter Co-host on shows from the Bubblesort Empire with John Chidgey, Clay Daly, Vic Hudson and Scott Willsey Avid Golden Knights fan... (Las Vegas Ice Hockey Team) APPLE Apple planning Face ID for MacBook Pro and iMac – plus a notch – Apple Insider Apple's going to put a notch on your MacBook? Is nothing sacred? – ZDNet Apple admits MacBook Air anti-reflective coating can exhibit ‘issues' – Cult of Mac Apple releases coronavirus screening app and website in partnership with CDC – CNN Apple updates Siri with new CDC questionnaire for queries about coronavirus – 9to5 Mac Darkroom photo editor updated with full mouse and trackpad support on iPadOS – 9to5 Mac Apple makes its pro video and audio editing software free to use for 90 days – Engadget Pro Apps Bundle for Education – Apple Kuo Hath Said the ARM is Nigh – Gizmodo TECHNOLOGY This is the most convincing Apple iMac clone we've seen yet – Tech Radar Sony Spins Off Camera Business Into Separate Company – PetaPixel Polaroid's new Now instant film camera delivers a classic, punishing experience – The Verge – The Verge SECURITY & PRIVACY Bug in iOS 13.3.1 and later keeps VPNs from encrypting traffic, but there's a simple workaround – 9to5 Mac Zoom iOS update removes 'feature' that sent user data to Facebook — Apple Insider WORTH A CHIRP / ESSENTIAL TIPS Darkroom photo editor updated with full mouse and trackpad support on iPadOS – 9to5 Mac Skylum donate EUR 5 from any purchase to fight COVID-19 and help victims of the coronavirus pandemic – Skylum NEMO'S HARDWARE STORE Nemo will be back as soon as the trucks can get to him... Essential Apple Recommended Services: Pixel Privacy – a fabulous resource full of excellent articles and advice on how to protect yourself online Ghostery – protect yourself from trackers, scripts and ads while browsing. 33mail.com – Never give out your real email address online again. Sudo – get up to 9 “avatars” with email addresses, phone numbers and more to mask your online identity. Free for the first year and priced from $0.99 US / £2.50 UK per month thereafter... ProtonMail – end to end encrypted, open source, based in Switzerland. Prices start from FREE... what more can you ask? ProtonVPN – a VPN to go with it perhaps? Prices also starting from nothing! Comparitech DNS Leak Test – simple to use and understand VPN leak test. Fake Name Generator – so much more than names! Create whole identities (for free) with all the information you could ever need. Wire – free for personal use, open source and end to end encryted messenger and VoIP. Pinecast – a fabulous podcast hosting service with costs that start from nothing. Essential Apple is not affiliated with or paid to promote any of these services... We recommend services that we use ourselves and feel are either unique or outstanding in their field, or in some cases are just the best value for money in our opinion. Social Media and Slack You can follow us on: Twitter / Slack / EssentialApple.com / Spotify / Soundcloud / YouTube / Facebook / Pinecast Also a big SHOUT OUT to the members of the Slack room without whom we wouldn't have half the stories we actually do – we thank you all for your contributions and engagement. You can always help us out with a few pennies by using our Amazon Affiliate Link so we get a tiny kickback on anything you buy after using it. If you really like the show that much and would like to make a regular donation then please consider joining our Patreon or using the Pinecast Tips Jar (which accepts one off or regular donations) And a HUGE thank you to the patrons who already do. Support The Essential Apple Podcast by contributing to their Tip Jar: https://tips.pinecast.com/jar/essential-apple-show This podcast is powered by Pinecast.

Recorded 5th May 2019 First of all deepest apologies for the very late posting of this edition - I won't bore you with the details but let's just say a holiday weekend, some life events and some work things meant I just didn't make the time to get it done as soon as I usually try to. Also there were a large amount of notes to compile regarding the “Starting Podcasting” section. Sorry, for the delay. Anyway in this episode I am joined by Guy Serle of the MyMac Podcast and more to talk about the end of Aperture, the forthcoming removal of 32 bit support in macOS and what that means for old software, the AirPod that lived, some clickbait headlines, Adobe “price rises” (or not), Chrome's dominance, a Firefox problem and finally a bit of “inside baseball” stuff about starting a podcast (on budget preferably). Next show I will endeavour not to be so tardy posting I promise. GIVEAWAYS & OFFERS Listeners of this show can claim $10 off purchases of Luminar and/or Aurora HD 2019 use the coupon code EssentialApple at checkout for your extra discount! Why not come and join the Slack community? You can now just click on this Slackroom Link to sign up and join in the chatter! We can now also be found on RadioPublic, PlayerFM and TuneIn as well as all the other places previously available. On this week's show: GUY SERLE On Twitter as @Macparrot and @VertShark Co-host of the MyMac Show Mac to the Future and Guy's Daily Drive on YouTube All his stuff is now at vertshark.com APPLE Apple's Aperture photo editing software will shutter for good after macOS Mojave – The Verge Quicktime 7, Carbon, Ink, Apple's hardware RAID support predicted to be gone in macOS 10.15 – Apple Insider AirPod survives trip through man who swallowed it – Cult of Mac Apple Accidentally Reveals Radical New iPhone – Forbes Apple Warns iPhone Users Not To Answer Apple Support Calls – Forbes Report: iPhone Battery Life Much Lower Than Apple's Claims – Redmond Pie TECHNOLOGY Adobe tests doubling the price of its Lightroom and Photoshop plan – The Verge Or maybe not – Adobe via Twitter A glitch is breaking all Firefox extensions – TechCrunch Fixed as of 1:00am EDT (mostly) – Mozilla And this is very interesting... look how dominant Chrome has become almost everywhere except "tablets" (i.e. iPad) – Wikipedia WORTH A CHIRP / ESSENTIAL TIPS I did not know this! Double tap time pickers to switch to 1 min granularity instead of 5 min – @rjonesy on Twitter Nemo's Hardware Store (30:02) myCharge HubMax Battery Charger for Tablets & Smartphones (with Free Shipping) $100 US – Amazon $90 US The Podcasting Stuff Samson Q2U Handheld Dynamic USB Microphone Recording and Podcasting Pack – $60 US / £85 UK Audio-Technica ATR2100-USB Cardioid Dynamic USB/XLR Microphone – $68 US / £100 UK BEHRINGER audio interface (UMC22) – $60 US BEHRINGER U-PHORIA UMC202HD, 2-Channel – $98 US / £64 UK BEHRINGER UMC 404HD Audiophile 4X4 24-Bit/192 KHz USB Audio/Midi Interface with Midas Mic Preamplifiers Black – $150 US / £110 UK This appears to be Simon's mic... the Logitech E-UR20 USB Microphone which appears under a host of guises... $20 US / £15 UK [Rogue Amoeba Software](https://rogueamoeba.com (https://rogueamoeba.com/) Makers of Loopback, Audio Hijack, Piezo, Farrago, Fission and more. If you don't want to pay out for Loopback as a beginner you can still get its forerunner Soundflower We didn't mention it on the show because I wasn't sure it was still available! Before Paul Kafasis introduced Farrago Simon used Soundplant which can be used free (with a few limitations... like you have to make your samples AIFF if you are using it for free) and to do that he used to use Media Human Audio Converter all of which worked well enough SoundStudio (also available in the Mac App Store) Other options mentioned or not – Spreaker and their Apps, Mixlr, Zencastr, Opinion and Ferrite There are interviews with Paul Kafasis of Rogue Amoeba and Canis of Wooji Juice (Ferrite Recording Studio), also Oliver Breidenbach of Boinx who make MiMo Live (a TV studio on your Mac), as well as a piece by Simon about recording and editing this podcast on www.essentialapple.com Guy's “if you have money to burn” suggestion Rode RodeCaster Pro Podcast Production Studio Guy's video "Using Loopback and Audio Hijack together for multitrack recording" on YouTube Guy's video "Using Loopback 2 for advanced Audio uses" on YouTube EDITING: There are a million options some which we mentioned and some we didn't: GarageBand (on the Mac App Store and iOS App Store), Audacity, SoundStudio, Fission, Ferrite, some of the web based services mentioned above, Reaper, Avid ProTools First and a whole load more. HOSTING: Simon uses Pinecast, Guy uses PodBean, and here is an article listing a whole slew of hosts Essential Apple Recommended Services: Ghostery - protect yourself from trackers, scripts and ads while browsing. 33mail.com – Never give out your real email address online again. Sudo – Get up to 9 “avatars” with email addresses, phone numbers and more to mask your online identity. Free for the first year and priced from $0.99 US / £2.50 UK per month thereafter... ProtonMail – End to end encrypted, open source, based in Switzerland. Prices start from FREE... what more can you ask? ProtonVPN – a VPN to go with it perhaps? Prices also starting from nothing! Fake Name Generator – So much more than names! Create whole identities (for free) with all the information you could ever need. Wire – Free for personal use, open source and end to end encryted messenger and VoIP. Pinecast – a fabulous podcast hosting service with costs that start from nothing. Essential Apple is not affiliated with or paid to promote any of these services... We recommend services that we use ourselves and feel are either unique or outstanding in their field, or in some cases are just the best value for money in our opinion. Social Media and Slack You can follow us on: Twitter / Slack / EssentialApple.com / Spotify / Soundcloud / YouTube / Facebook / Pinecast Also a big SHOUT OUT to the members of the Slack room without whom we wouldn't have half the stories we actually do – we thank you all for your contributions and engagement. You can always help us out with a few pennies by using our Amazon Affiliate Link so we get a tiny kickback on anything you buy after using it. If you really like the show that much and would like to make a regular donation then please consider joining our Patreon or using the Pinecast Tips Jar (which accepts one off or regular donations) And a HUGE thank you to the patrons who already do. This podcast is powered by Pinecast.

Frances and Andrew met a few years ago during a mission/ce trip in Guatemala and have been friends since! We welcome her to the podcast and discuss, among other things… - We talk about how to find jobs in hygiene - her work with Acteon How hygienists accept in office training Piezo units Perioscopes Emdogain is discussed again for off label use! Edie jumps in 10 minutes into the interview!! We talked about Frances owning her own practice and the different states she has worked in Why she went to Guatemala in the first place and a little of her experience there How other people are stronger than Americans http://www.dentistryiq.com/articles/2014/08/jenn-s-vision-a-true-lesson-in-best-practices.html Papoosing children How to charge to insurance or patient portions in her own practice? How did the patient get referred to her practice? Was she supported in the community?

Ok, things got a little crazy on this episode. A lot of people have asked me about the best place to put piezo pickups. I love to experiment so I learnt a lot on this episode about wiring up piezo pickups and I was even able to confirm what I enjoy about my choice of piezo placement. Hope you enjoy the episode and tell your friends. Adam

An exploration into the Aeolian tones of field recording, an art which uses contact microphones to summon alien compositions from the depths of seemingly benign ponds, bridges, and fence-posts. Produced by Lawrence Dunn.