Podcasts about qcs

In “The 5 Failures of Final Mile,” Joe Lynch and Jason Burns, Host of Last2First Podcast and Insurance Producer at CUI Agency, discuss the common mistakes that final mile companies make.  About Jason Burns Jason Burns is a native of New Orleans and a passionate business leader in the final mile transportation industry. He is a 2006 graduate of Vanderbilt University where he was a SEC Academic Honor Roll student-athlete in football and selected as the recipient of the Head Coach's Dedication Award. After beginning his professional career in the parking industry, Jason returned to his hometown to assume a leadership role in his family's business enterprises, including Burns Management Group (BMG), Global Parking Systems (GPS), and QCS Logistics (formerly Quick Courier Services, Inc). As a second-generation owner and President of QCS, Mr. Burns led the company's resurgence by developing new service offerings, implementing a new technology platform, and expanding operations into new markets. These initiatives resulted in record growth and QCS was selected to the Inc. 5000 list as one of America's fastest growing companies for four consecutive years. QCS was also recognized as a Top 100 Icon of Industry by ICIC (Initiative for a Competitive Inner City) in 2014. In 2020, QCS was acquired by Dropoff Inc, a national same-day delivery company headquartered in Austin, Tx. with operations in over 25 states. In this new role, he served as Dropoff's Director of Corporate Development, leading the company's M&A efforts. In 2022, Dropoff was ranked #2,607 on the annual Inc. 5000 list of the fastest-growing private companies in America. He recently transitioned into the commercial insurance industry joining CUI Agency, focusing on bringing transportation literacy to owners who are challenged with finding solutions to the increasing cost of insurance. In 2022, Jason was elected as the first African-American President of the Customized Logistics and Delivery Association (CLDA), the nation's leading association for the final mile delivery industry since 1987. He now serves as the Immediate Past President. When he's not on the clock, you can find Jason spending time with his pride and joy; 9-year-old twins Jason Jr. (JJ) and Jordyn (JoJo). He coaches JJ's travel baseball & JoJo's flag football teams and is one of the loudest dads cheering from the sidelines. By the end of 2024, he launched the Last2First podcast. Through his engaging podcast, Last2First, he extends an open invitation to final-mile enthusiasts, entrepreneurs, and transportation professionals, encouraging a collaborative exploration of strategies, innovations, and stories of transformation. Jason's mission is clear: to share the wealth of knowledge he's accumulated, fostering a community where every member can thrive from last to first. About Last2First Podcast The Last2First (L2F) Podcast, hosted by Jason Burns, is a trusted resource for entrepreneurs, enthusiasts, and leaders in the first, middle, and last-mile delivery industry. Focused on actionable insights and expert interviews, the podcast empowers listeners with inspiring and insightful information to lead their businesses and succeed in this dynamically growing market. Join them as they dive into topics like optimizing delivery routes, enhancing customer satisfaction, navigating regulatory hurdles, and leveraging technology for efficiency. Whether they're a seasoned logistics professional or a business owner looking to improve their operations, Last 2 First offers valuable insights and actionable advice to help them lead their business to success. Key Takeaways: The 5 Failures of Final Mile In “The 5 Failures of Final Mile,” Joe Lynch and Jason Burns, Host of Last2First Podcast and Insurance Producer at CUI Agency, discuss the common mistakes that final mile companies make. Understanding the True Cost of Final Mile: Many businesses underestimate the hidden costs associated with final mile delivery, leading to underpriced services and financial strain. Navigating Driver Classification: Properly classifying drivers as employees or independent contractors is crucial to avoid legal issues and ensure compliance in the final mile industry. Strategic Customer Selection: Not all customers are equally valuable. The episode highlights the importance of strategically choosing clients to ensure sustainable growth and profitability. The Impact of Your Services: Recognize the significant impact final mile services have on the overall customer experience, and value your offerings accordingly. Protecting Your Business with Proper Insurance: Adequate and appropriate insurance coverage is essential for mitigating risks and safeguarding your final mile business from unforeseen liabilities. Actionable Insights for Success: Drawing from the expertise shared by Jason Burns, the episode provides practical advice for entrepreneurs and leaders in the delivery industry. Learn More About The 5 Failures of Final Mile Jason Burns | Linkedin Last2First Podcast | LinkedIn Last2First Podcast Last2First Podcast | Youtube Lst2First Podcast | Spotify Last2First Podcast | Apple Podcasts Last2First Podcast | Instagram Last2First Podcast | Facebook Last2First Podcast | Email The Logistics of Logistics Podcast If you enjoy the podcast, please leave a positive review, subscribe, and share it with your friends and colleagues. The Logistics of Logistics Podcast: Google, Apple, Castbox, Spotify, Stitcher, PlayerFM, Tunein, Podbean, Owltail, Libsyn, Overcast Check out The Logistics of Logistics on Youtube

In this episode of The Care Social, Barry, our Content Operations and Delivery Manager at QCS, explores how care providers can effectively respond after a regulatory downgrade — a growing concern in light of recent CQC developments.Whether you've just been through an inspection or want to strengthen your approach, Barry shares calm, clear-headed advice on how to respond, rebuild, and refocus.Key topics covered:Immediate steps after receiving an inspection outcomeCommunicating transparently with staff, stakeholders, and service usersRebuilding morale and protecting your teamUsing inspection findings to update training and recruitment plansMaintaining continuity of care and restoring trustCreating and embedding a culture of continuous improvementTracking progress and preparing for follow-up inspections

In this episode of The Care Social, we're joined by Tandeep Gill, Head of Business Development UK and Ireland for PainChek.Tandeep shares how PainChek's innovative technology is giving a voice to people who cannot verbalise their pain, helping carers spot and manage pain earlier, and improving outcomes across the sector.Find out how pain assessment is being embedded into policies, how it supports safeguarding and better evidence for funding requests, and how PainChek is working alongside care management systems like QCS, to transform the way you deliver care.

Hosted by Barry Price, Content Operations and Delivery Manager at QCS, this episode of The Care Social tackles one of the biggest challenges in adult social care – making training truly meaningful.Forget box-ticking. Barry explores how getting your training right can transform the quality of care and support in your service.In this solo episode, Barry shares:Why skipping a proper Training Needs Analysis is a costly mistakeHow to match training to the actual needs of your service users – not a generic templateThe importance of adapting to different learning stylesSimple ways to keep your training plan fresh, relevant, and effectiveWhether you're managing a care service or working on the front line, this episode gives you practical advice you can use straight awayListen now.Want to join the conversation?If you have any topics you'd like us to cover or want to be a guest on a future episode, email us at qcs@qcs.co.uk

Listen to Lindsay talk about her work for QCS and what she commonly sees in both 'good' and 'outstanding' services.  She gives some great tips on effectively auditing and making improvements. We also talk about her passion project around falls based on best practice research around falls risk assessment and how a 'falls huddle' can make a difference.   Resources Guide to improvement; Learning from accidents and events digital module  External resources on the falls project   Action Falls Train the Trainer Course | Action Falls Program | University of Nottingham Online  Best practice to reduce risk in your care home using the ACTiON FALLS programme | QCS 

Listen in as we chat about Sana, Sana: Latinx Pain and Radical Visions for Healing and Justice, with Editor David Luis Glisch-Sánchez, Editor Nic Rodriguez-Villafañe and Intercultural Wellness Coordinator & Counselor, Stacey Lopez, LCSW, QCS. As always, we'll share meaningful segments and discuss how many of these bookish moments connect to our lives. Don't forget about our choice of emoji at the end!

This month on Episode 47 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the March 31 issue of Circulation Research. We'll also provide an overview of the Compendium on Increased Risk of Cardiovascular Complications in Chronic Kidney Disease published in the April 14 issue. Finally, this episode features an interview with Dr Elizabeth Tarling and Dr Bethan Clifford from UCLA regarding their study, RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels.   Article highlights:   Shi, et al. LncRNAs Regulate SMC Phenotypic Transition   Chen, et al. Bilirubin Stabilizes Atherosclerotic Plaque   Subramaniam, et al. Mapping Non-Obvious cAMP Nanodomains by Proteomics   Compendium on Increased Risk of Cardiovascular Complications in Chronic Kidney Disease   Cindy St. Hilaire:              Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to share three articles selected from our March 31st issue of Circulation Research and give you a quick summary of our April 14th Compendium. I'm also excited to speak with Dr Elizabeth Tarling and Dr Bethan Clifford from UCLA regarding their study, RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels.   So first the highlights. The first article we're going to discuss is Discovery of Transacting Long Noncoding RNAs that Regulates Smooth Muscle Cell Phenotype. This article's coming from Stanford University and the laboratory of Dr Thomas Quertermous. Smooth muscle cells are the major cell type contributing to atherosclerotic plaques. And in plaque pathogenesis, the cells can undergo a phenotypic transition whereby a contractile smooth muscle cell can trans differentiate into other cell types found within the plaque, such as macrophage-like cells, osteoblast-like cells and fibroblast-like cells. These transitions are regulated by a network of genetic and epigenetic mechanisms, and these mechanisms govern the risk of disease.   The involvement of long non-coding RNAs, or Lnc RNAs as they're called, has been increasingly identified in cardiovascular disease. However, smooth muscle cell Lnc RNAs have not been comprehensively characterized and the regulatory role in the smooth muscle cell state transition is not thoroughly understood. To address this gap, Shi and colleagues created a discovery pipeline and applied it to deeply strand-specific RNA sequencing from human coronary artery smooth muscle cells that were stressed with different disease related stimuli. Subsequently, the functional relevancy of a few novel Lnc RNAs was verified in vitro.   From this pipeline, they identified over 4,500 known and over 13,000 unknown or previously unknown Lnc RNAs in human coronary artery smooth muscle cells. The genomic location of these long noncoding RNAs was enriched near coronary artery disease related transcription factor and genetic loci. They were also found to be gene regulators of smooth muscle cell identity. Two novel Lnc RNAs, ZEB-interacting suppressor or ZIPPOR and TNS1-antisense or TNS1-AS2, were identified by the screen, and this group discovered that the coronary artery disease gene, ZEB2, which is a transcription factor in the TGF beta signaling pathway, is a target for these Lnc RNAs. These data suggest a critical role for long noncoding RNAs in smooth muscle cell phenotypic transition and in human atherosclerotic disease.   Cindy St. Hilaire:              The second article I want to share is titled Destabilization of Atherosclerotic Plaque by Bilirubin Deficiency. This article is coming from the Heart Research Institute and the corresponding author is Roland Stocker. The rupture of atherosclerotic plaque contributes significantly to cardiovascular disease. Plasma concentrations of bilirubin, a byproduct of heme catabolism, is inversely associated with risk of cardiovascular disease, but the link between bilirubin and atherosclerosis is unknown.   Chen et el addressed this gap by crossing a bilirubin knockout mice to a atherosclerosis prone APOe knockout mouse. Chen et el addressed this gap by crossing the bilirubin knockout mouse to the atherosclerosis-prone APOE knockout mouse, and used the tandem stenosis model of plaque instability to address this question. Compared with their litter mate controls, bilirubin-APOE double knockouts showed signs of increased systemic oxidative stress, endothelial dysfunction, as well as hyperlipidemia. And they had higher atherosclerotic plaque burden.   Hemeatabolism was increased in unstable plaques compared with stable plaques in both of these groups as well as in human coronary arteries. In mice, the bilirubin deletion selectively destabilized unstable plaques and this was characterized by positive arterial remodeling and increased cap thinning, intra plaque hemorrhage, infiltration of neutrophils and MPO activity. Subsequent proteomics analysis confirmed bilirubin deletion enhanced extracellular matrix degradation, recruitment and activation of neutrophils and associated oxidative stress in the unstable plaque. Thus, bilirubin deficiency generates a pro atherogenic phenotype and selectively enhances neutrophil-mediated inflammation and destabilization of unstable plaques, thereby providing a link between bilirubin and cardiovascular disease risk.   Cindy St. Hilaire:              The third article I want to share is titled Integrated Proteomics Unveils Regulation of Cardiac Monocyte Hypertrophic Growth by a Nuclear Cyclic AMP Nano Domain under the Control of PDE3A. This study is coming from the University of Oxford in the lab of Manuela Zaccolo. Cyclic AMP is a critically important secondary messenger downstream from a myriad of signaling receptors on the cell surface. Signaling by cyclic AMP is organized in multiple distinct subcellular nano domains, regulated by cyclic AMP hydrolyzing phosphodiesterases or PDEs.   The cardiac beta adrenergic signaling has served as the prototypical system to elucidate this very complex cyclic AMP compartmentalization. Although studies in cardiac monocytes have provided an understanding of the location and the properties of a handful of these subcellular domains, an overview of the cellular landscape of the cyclic AMP nano domains is missing.   To understand the nanodynamics, Subramanian et al combined an integrated phospho proteomics approach that took advantage of the unique role that individual phosphodiesterases play in the control of local cyclic AMP. They combined this with network analysis to identify previously unrecognized cyclic AMP nano domains associated with beta adrenergic stimulation. They found that indeed this integrated phospho proteomics approach could successfully pinpoint the location of these signaling domains and it provided crucial cues to determine the function of previously unknown cyclic AMP nano domains.   The group characterized one such cellular compartment in detail and they showed that the phosphodiesterase PDE3A2 isoform operates in a nuclear nano domain that involves SMAD4 and HDAC1. Inhibition of PDE3 resulted in an increased HDAC1 phosphorylation, which led to an inhibition of its deacetylase activity, and thus derepression of gene transcription and cardiac monocyte hypertrophic growth. These findings reveal a very unique mechanism that explains the negative long-term consequences observed in patients with heart failure treated with PDE3 inhibitors.   Cindy St. Hilaire:              The April 14th issue is our compendium on Increased Risk of Cardiovascular Complications in Chronic Kidney Disease. Dr Heidi Noels from the University of Aachen is our guest editor of the 11 articles in this issue. Chronic kidney disease is defined by kidney damage or a reduced kidney filtration function. Chronic kidney disease is a highly prevalent condition affecting over 13% of the population worldwide and its progressive nature has devastating effects on patient health. At the end stage of kidney disease, patients depend on dialysis or kidney transplantation for survival. However, less than 1% of CKD patients will reach this end stage of chronic kidney disease. Instead, most of them with moderate to advanced chronic kidney disease will prematurely die and most often they die from cardiovascular disease. And this highlights the extreme cardiovascular burden patients with CKD have.   The titles of the articles in this compendium are the Cardio Kidney Patient Epidemiology, Clinical Characteristics, and Therapy by Nicholas Marx, the Innate Immunity System in Patients with Cardiovascular and Kidney Disease by Carmine Zoccali et al. NETs Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney disease by Yvonne Doering et al. Accelerated Vascular Aging and Chronic Kidney Disease, The Potential for Novel Therapies by Peter Stenvinkel et al. Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients with Chronic Kidney Disease by Heidi Noels et al. Cardiovascular Calcification Heterogeneity in Chronic Kidney Disease by Claudia Goettsch et al. Fibrosis in Pathobiology of Heart and Kidney From Deep RNA Sequencing to Novel Molecular Targets by Raphael Kramann et al. Cardiac Metabolism and Heart Failure and Implications for Uremic Cardiomyopathy by P. Christian Schulze et al. Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease by Michael Burnier et al. Role of the Microbiome in Gut, Heart, Kidney crosstalk by Griet Glorieux et al, and Use of Computation Ecosystems to Analyze the Kidney Heart Crosstalk by Joachim Jankowski et al.   These reviews were written by leading investigators in the field, and the editors of Circulation Research hope that this comprehensive undertaking stimulates further research into the path flow of physiological kidney-heart crosstalk, and on comorbidities and intra organ crosstalk in general.   Cindy St. Hilaire:              So for our interview portion of the episode I have with me Dr Elizabeth Tarling and Dr Bethan Clifford. And Dr Tarling is an associate professor in the Department of Medicine in cardiology at UCLA, and Dr Clifford is a postdoctoral fellow with the Tarling lab. And today we're going to be discussing their manuscript that's titled, RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels. So thank you both so much for joining me today.   Elizabeth Tarling:             Thank you for having us.   Bethan Clifford:               Yeah, thanks for having us. This is exciting.   Cindy St. Hilaire:              I guess first, Liz, how did you get into this line of research? I guess, before we get into that, I should disclose. Liz, we are friends and we've worked together in the ATVB Women's Leadership Committee. So full disclosure here, that being said, the editorial board votes on these articles, so it's not just me picking my friends. But it is great to have you here. So how did you enter this field, I guess, briefly?   Elizabeth Tarling:             Yeah, well briefly, I mean my training right from doing my PhD in the United Kingdom in the University of Nottingham has always been on lipid metabolism, lipoprotein biology with an interest in liver and cardiovascular disease. So broadly we've always been interested in this area and this line of research. And my postdoctoral research was on atherosclerosis and lipoprotein metabolism. And this project came about through a number of different unique avenues, but really because we were looking for regulators of LDL biology and plasma LDL cholesterol, that's sort of where the interest of the lab lies.   Cindy St. Hilaire:              Excellent. And Bethan, you came to UCLA from the UK. Was this a topic you were kind of dabbling in before or was it all new for you?   Bethan Clifford:               It was actually all completely new for me. So yeah, I did my PhD at the same university as Liz and when I started looking for postdocs, I was honestly pretty adamant that I wanted to stay clear away from lipids and lipid strategy. And then it wasn't until I started interviewing and meeting people and I spoke to Liz and she really sort of convinced me of the excitement and that the interest and all the possibilities of working with lipids and well now I won't go back, to be honest.   Cindy St. Hilaire:              And now here you are. Well-   Bethan Clifford:               Exactly.   Cindy St. Hilaire:              ... congrats on a wonderful study. So LDLR, so low density lipoprotein receptor, it's a major determinant of plasmid LDL cholesterol levels. And hopefully most of us know and appreciate that that is really a major contributor and a major risk for the development of atherosclerosis and coronary artery disease. And I think one thing people may not really appreciate, which your study kind of introduces and talks about nicely, is the role of the liver, right? And the role of receptor mediated endocytosis in regulating plasma cholesterol levels. And so before we kind of chat about the nitty-gritty of your study, could you just give us a brief summary of these key parts between plasma LDL, the LDL receptor and where it goes in your body?   Elizabeth Tarling:             Yeah. So the liver expresses 70% to 80% of the body's LDL receptor. So it's the major determinant of plasma lipoprotein plasma LDL cholesterol levels. And through groundbreaking work by Mike Brown and Joe Goldstein at the University of Texas, they really define this receptor mediated endocytosis by the liver and the LDL receptor by looking at patients with familial hypercholesterolemia. So those patients have mutations in the LDL receptor and they either express one functional copy or no functional copies of the LDL receptor and they have very, very large changes in plasma LDL cholesterol. And they have severe increases in cardiovascular disease risk and occurrence and diseases associated with elevated levels of cholesterol within the blood and within different tissues. And so that's sort of how the liver really controls plasma LDL cholesterol is through this receptor mediated endocytosis of the lipoprotein particle.   Cindy St. Hilaire:              There's several drugs now that can help regulate our cholesterol levels. So there's statins which block that rate limiting step of cholesterol biosynthesis, but there's this new generation of therapies, the PCSK9 inhibitors. And can you just give us a summary or a quick rundown of what are those key differences really? What is the key mechanism of action that these therapies are going after and is there room for more improvement?   Bethan Clifford:               Yeah, sure. So I mean I think you've touched on something that's really key about the LDR receptor is that it's regulated at so many different levels. So we have medications available that target the production of cholesterol and then as you mentioned this newer generation of things like PCSK9 inhibitors that sort of try and target LDL at the point of clearance from the plasma.   And in response to your question of is there room for more regulation, I would say that given the sort of continual rate of increased cholesterol in the general population and the huge risks associated with elevated cholesterol, there's always capacity for more to improve that and sort of generally improve the health of the population. And what we sort of found particularly exciting about RNF130 is that it's a distinct pathway from any of these regulatory mechanisms. So it doesn't regulate the level of transcription, it doesn't regulate PCSK9. Or in response to PCSK9, it's a completely independent pathway that could sort of improve or add to changes in cholesterol.   Cindy St. Hilaire:              So your study, it's focusing on the E3 ligase, RNF130. What is an E3 ligase, and why was this particular one of interest to you? How did you come across it?   Elizabeth Tarling:             is predTates Bethan joining the lab. This is, I think, again for the listeners and those people in training, I think it's really important to note this project has been going in the lab for a number of years and has really... Bethan was the one who came in and really took charge and helped us round it out. But it wasn't a quick find or a quick story. It had a lot of nuances to it. But we were interested in looking for new regulators of LDL cholesterol and actually through completely independent pathways we had found the RNF130 locus as being associated with LDL cholesterol in animals. And then it came out in a very specific genome-wide association study in the African American care study, the NHLBI care study. And so really what we started looking at, we didn't even know what it was.   Elizabeth Tarling:             So we asked ourselves, well what is this gene? What is this protein? And it's RNF, so that's ring finger containing protein 130 and ring stands for really interesting new gene. Somebody came up with the glorious name. But proteins that contain this ring domain are very characteristic and they are E3 ubiquitin ligases. And so they conjugate the addition of ubiquitin to a target protein and that signals for that protein to either be internalized and/or degraded through different decorative pathways within the cell. And so we didn't land on it because we were looking at E3 ligases, we really came at it from an LDL cholesterol perspective. And it was something that we hadn't worked on before and the study sort of blossomed from there.   Cindy St. Hilaire:              That's amazing and a beautiful, but also, I'm sure, heartbreaking story because these long projects are just... They're bears. So what does this RNF130 do to LDLR? What'd you guys find?   Bethan Clifford:               As Liz said, this is a long process, but one of the key factors of RNF130 is it's structurally characteristically looked like E3 ligase. So the first thing that Liz did and then I followed up with in the lab is to see is this E3 ligase ubiquitinating in vitro. And if it is going to ubiquitinate, what's it likely to regulate that might cause changes in plasma cholesterol that would explain these human genetic links that we saw published at the same time.   And so because the LDL cholesterol is predominantly regulated by the LDL receptor and the levels of it at the surface of the parasites in the liver, the first question we wanted to see is does RNF130 interact in any way with that pathway? And I'm giving you the brief view here of the LDL receptor. We obviously tested lots of different receptors. We tested lots of different endocytose receptors and lipid regulators, but the LDL receptor is the one that we saw could be ubiquitinated by RNF130 in vitro. And so then we wanted to sort of go on from there and establish, okay, if this E3 ubiquitin ligase, is it regulating LDL receptor? What does that mean in an animal context in terms of regulating LDL cholesterol?   Cindy St. Hilaire:              Yeah, and I guess we should also explain, ubiquitination, in terms of this receptor, and I guess related to Goldstein and Brown and receptor mediated endocytosis, like what does that actually mean for the liver cell and the cholesterol in the LDLR that is binding the receptor?   Bethan Clifford:               So yes, ubiquitination is a really common regulatory mechanism actually across all sorts of different cells, all sorts of different receptors and proteins. And basically what it does is it signals for degradation of a protein. So a ubiquitin molecule is conjugated to its target such as in our case the LDL receptor and that ubiquitin tells the cell that this protein is ready for proteasomal degradation. And that's just one of the many things ubiquitination can do. It can also signal for a trafficking event, it can signal for a protein to protein interaction, but it's most commonly associated with the proteasomal degradation.     Cindy St. Hilaire:              So in terms of... I guess I'm thinking in terms of PCSK9, right? So those drugs are stemming from observations in humans, right? There were humans with gain and loss of function mutations, which caused either more or less of this LDLR receptor internalization. How is this RNF130 pathway different from the PCSK9 activities?   Elizabeth Tarling:             Yeah, so PCSK9 is a secreted protein, so it's made by hepatocyte and actually other cells in the body and it's secreted and it binds to the LDL particle, LDL receptor complex, and signals for its internalization and degradation in the proteasome. So this is not ubiquitination event, this is a completely different trafficking event. And so the RNF130, actually what Bethan showed, is it directly ubiquitinates the LDL receptor itself, signaling for an internalization event and then ultimately degradation of the LDR receptor through a decorative pathway, which we also define in the study.   So these are two unique mechanisms and actually some key studies that we did in the paper were to modulate RNF130 in animals that do not have PCSK9. And so in that system where in the absence of PCSK9 you have a lot of LDR receptor in the liver that's internalizing cholesterol. What happens when you overexpress RNF130? Do you still regulate at the LDL receptor? And you absolutely do. And so that again suggests that they're two distinct mechanisms and two distinct pathways.   Cindy St. Hilaire:              That was one thing I really loved about your paper is every kind of figure or section, the question that would pop up in my head, even ones that didn't pop in my head were beautifully answered with some of these really nice animal models, which is never an easy thing, right? And so one of the things that you brought up was difficulty in making one of the animal models. And so I'm wondering if you could share a little bit for that challenge. I think one thing that we always tend to hide is just science is hard and a lot of what we do doesn't work. And I really think especially for the trainees and really everyone out there, if we kind of share these things more, it's better. So what was one of the most challenging things in this study? And I guess I'm thinking about that floxed animal.   Elizabeth Tarling:             Yeah, so I'll speak a bit about that and then I'll let Bethan address because she was really the one on the ground doing a lot of the struggles. But again, we actually weren't going to include this information in the paper. And upon discussion and actually prompted by the reviewers of the paper and some of the questions that they asked us, we realized, you know what? It's actually really important to show this and show that this happens and that there are ways around it.   And so the first story is before Bethan even arrived in the lab, we had purchased embryonic stem cells that were knockout first condition already. And so this is a knockout strategy in which the exon of interest is flanked with lots of P sites so that you can create a flox animal, but also so you can create a whole body knockout just by the insertion of this knockout first cassette.   Elizabeth Tarling:             And so we got those mice actually in the first year of Bethan joining the lab. We finally got the chimeric mice and we were able to stop reading those mice. And at the same time we tried to generate our flox animals so that we could move on to do tissue-specific studies. And Bethan can talk about the pain associated with this. But over two years of breeding, we never got the right genotypes from the different crosses that you need to do to generate the flox animal.   And it was actually in discussions with Bethan where we decided we need to go back. We need to go back to those ESLs that we purchased five years ago and we need to figure out if all of the elements that the quality control step had told us were in place are actually present. And so Bethan went back and sequenced the whole locus and the cassette to figure out what pieces were present and we found that one of the essential locks P sites that's required for every single cross from the initial animal was absent and therefore we could actually never make the mouse we wanted to make.   And so that's sort of just a lesson for people going down that route and making these tools that we need in the lab to answer these questions is that despite paying extra money and getting all of the sort of QCs that you can get before you receive the ESLs, we should have gone back and done our own housekeeping and sort of a long journey told us when we went back that we didn't have what we thought we had at the beginning. And that was a real sticking point as Bethan can-   Cindy St. Hilaire:              Yeah. And so you know you're not alone. My very first postdoc that I did, I went with a mouse that they had also bought and were guaranteed that it was a knockout and it was not. And it is a painful lesson, but it is critical to... You get over it.   So Bethan, maybe you can also tell us a little bit about what are the other kind of next things you tried? You pivoted and you pivoted beautifully because all the models you used I thought were quite elegant in terms of exactly asking the question you wanted to ask in the right cells. So can you maybe explain some of the in vivo models you used for this study?   Bethan Clifford:               Sure, there are definitely a lot. So I mean I think Liz sort of encapsulated the trouble we have with the knockout really succinctly, but actually I want to just take this moment to sort of shout out to another postdoc in the Tarling lab, Kelsey Jarrett, who was really instrumental in the pivoting to a different model. So for the knockouts when we sort of established we didn't have exactly what we thought we did and then to compound that we also weren't getting the DeLiAn ratios breeding this whole body knockout.   We wanted to sort of look at a more transient knockout model. And that's where Kelsey really stepped in and sort of led the way and she generated AAV-CRISPR for us to target RNF130 specifically in the liver. And that had the added beauty of, one, not requiring breeding to get over this hurdle of the knockout being somewhat detrimental to breeding. But it also allowed us to ask the question of what RNF130 is doing specifically in the liver where the liver regulates LDL receptor and LDL cholesterol.   And so that was one of the key models that really, really helped get this paper over the finish line. But we did a whole barrage of experiments, as you've seen. We wanted to make sure... One of the key facets of the Tarling lab is whenever you do anything, no matter what you show Liz, it will always be, "Okay, you showed it to me one way, now show it to me a different way." Can you get the same result coming at it from different ways? And if you can't, why is that? What is the regulation behind that? And so that's really what the paper is doing is asking the same question in as many ways as we can accurately and appropriately probe what RNF130 does to the LDR receptor.   So we tried gain of function studies without adenovirus overexpression. We tried transient knockdown with antisense oligonucleotides, and then we did, as I said, the AAV-CRISPR knockdown with the help of Kelsey and our whole body knockout. And then we also repeated some of these studies such as the adenovirus and the ASO in specific genetic backgrounds. So in the absence of PCSK9, can we still regulate the LDL receptor? And then we also, just to really confirm this, in the absence of the LDL receptor, do we see a difference? And the answer is no, because this effect was really dependent on that LDL receptor being present. So there was a big combination.   Cindy St. Hilaire:              It was really nice, really a beautiful step-wise progression of how to solidly answer this question. But a lot of, I think, almost all you did was in mice. And so what is the genetic evidence for relevancy in humans? Can you discuss a little bit about those databases that you then went to to investigate, is this relevant in humans?   Bethan Clifford:               I think Liz might be better off answering that question.   Elizabeth Tarling:             And I think this sort of pivots on what Bethan was saying. So when we had struggles in the lab, it was a team environment and a collaboration between people in the lab that allowed us to make that leap and make those next experiments possible to then really answer that question. And to be able to include the antisense oligonucleotides required a collaboration with industry. We were very lucky to have a longstanding collaboration with Ionis, who provided the antisense oligonucleotides.   And for the human genetics side of things, that also was a collaboration with Marcus Seldin, who was a former postdoc with Jake Lusis and is now our PI at UC Irvine. And what he helped us do is dive into those summary level databases and ask from that initial study in the NHLBI care population, do we see associations of RNF130 expression in humans with LDL cholesterol with cardiovascular outcomes. And so one database which I would recommend everybody use, it's publicly available, is the StarNet database. And it's in the paper and the website is there. And that allowed us to search for RNF130.   Elizabeth Tarling:             And what it does is it asks how RNF130 expression in different tissues is associated with cardiometabolic outcomes and actual in CAD cases and controls, so people with and without heart disease. And we found that expression of RNF130 in the liver was extremely strongly correlated with the occurrence of cardiovascular disease in people with CAD. So in cases versus controls. And then we were also able to find many other polymorphisms in the RNF130 locus that were associated with LDL cholesterol in multiple different studies.   And I think the other message from this paper is this, unlike PCSK9 and unlike LDR receptor itself, which are single gene mutations that cause cardiovascular disease, there are many sub genome-wide significant loci that contribute to this multifactorial disease, which is extremely complex. And I think RNF130 falls within that bracket that those sort of just on the borderline of being genome-wide significant still play significant biological roles in regulating these processes. And they don't come up as a single gene hit for a disease, but combinatorialy they are associated with increased risk of disease and they have a molecular mechanism that's associated with the disease. And so that's what Marcus helped us do in terms of the human genetics is really understand that and get down to that level of data.   Cindy St. Hilaire:              Yeah. Yeah, it really makes you want to go back and look at those. Everyone always focuses on that really high peak and those analyses, but what are all those other ones above the noise, right? So it's really important.   Elizabeth Tarling:             I think it's really hard to do that. I think that's one where people... Again, it comes down to team science and the group of people that we brought together allowed us to ask that molecular question about how that signal was associated with the phenotype. I think by ourselves we wouldn't have been able to do it.   Cindy St. Hilaire:              Yeah. So your antisense oligonucleotide experiments, they were really nice. They showed, I think it was a four-week therapy, they showed that when you injected them expression of RNF130 went down by 90%. I think cholesterol in the animals was lowered by 50 points or so. Is this kind of a next viable option? And I guess related to that, cholesterol's extremely important for everything, right? Cell membrane integrity, our neurons, all sorts of things. Is it possible with something that is perhaps really as powerful as this to make cholesterol too low?   Elizabeth Tarling:             I think that what we know from PCSK9 gain and loss of function mutations is that you can drop your plasma cholesterol to very low levels and still be okay because there are people walking around with mutations that do that. I think RNF130 is a little different in that it's clearly regulatory in a homeostatic function in that it's ubiquitously expressed and it has this role in the liver to regulate LDL receptor availability, but there are no homozygous loss of function mutants people walking around, which tells us something else about how important it is in potentially other tissues and in other pathways. And we've only just begun to uncover what those roles might be.   So I think that as a therapy, it has great potential. We need to do a lot more studies to sort of move from rodent models into more preclinical models. But I do think that the human data tell us that it's really important in other places too. And so yeah, we need to think about how best it might work as a therapy. If it's combinatorial, if it's dosed. Those are the types of things that we need to think about.   Cindy St. Hilaire:              Yeah, it's really exciting. Do you know, are there other protein targets of RNF130? Is that related to my next question of what is next?   Elizabeth Tarling:             I mean, so I should point out, so Bethan unfortunately left the lab last year for a position at Amgen where she's working on obesity and metabolic disease. But before she left, she did two very, very cool experiments searching for new targets or additional targets of RNF130. Starting in the liver, but hopefully we'll move those into other tissues. And so she did gain of function RNF130 versus what loss of function we have of RNF130, and she did specific mass spec analysis of proteins that are ubiquitinated in those different conditions. And by overlaying those data sets, we're hoping to carve out new additional targets of RNF130. And there are some, and they're in interesting pathways, which we have yet to completely test, but definitely there are additional pathways, at least when you overexpress and reduce expression. Now, whether they turn out to be, again, bonafide in vivo, actual targets that are biologically meaningful is sort of the next step.   Cindy St. Hilaire:              Yeah. Well, I'm sure with your very rigorous approach, you are going to find out and hopefully we'll see it here in the future. Dr Elizabeth Tarling and Dr Bethan Clifford, thank you so much for joining me today. I really enjoyed this paper. It's a beautiful study. I think it's a beautiful example, especially for trainees about kind of thoroughly and rigorously going through and trying to test your hypothesis. So thanks again.   Elizabeth Tarling:             Thank you.   Bethan Clifford:               Thank you very much.   Cindy St. Hilaire:              That's it for the highlights from the March 31st and April 14th issues of Circulation Research. Thank you for listening. Please check out the Circulation Research Facebook page and follow us on Twitter and Instagram with the handle @CircRes, and #DiscoverCircRes. Thank you to our guests, Dr Liz Tarling and Dr Bethan Clifford.   This podcast is produced by Ishara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, you're on-the-go source for the most exciting discoveries in basic cardiovascular research.   This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.  

Leslie Touzeau, Organic Policy Manager at QCS (Quality Certification Services), chats with Juan Carlos Rodriguez about how she came across this career path, experiences that contributed to her current role, and places to look further to launch oneself into the organic food industry.  Tune in to learn about: - Leslie's background and pathway to her current role - Applicable skills and experiences to get started in organics - Specific roles and opportunities at QCS - Resources for careers in organics/ the food industry Find more organics career info and opportunities here: International Organic Inspectors Association World Wide Opportunities on Organic Farms Organic Trade Association We hope you enjoyed the episode! Please help us continue to produce more valuable content by subscribing to our Fresh Take Podcast Series! Subscribe here SPONSORSHIP OPPORTUNITY- Learn more about the many benefits of becoming a Sponsor of Florida Organic Growers!  Your contribution will not only help to advance an organic and sustainable future but gain brand awareness through our growing audience. If you are interested, click here  Support the show

Anna Cesarotti, Associate Director of Organic Certification at QCS (Quality Certification Services), speaks with Juan Carlos Rodriguez about career opportunities in the growing industry of organics. In this episode, learn about: - How Anna came to work in organics - Types of careers in the organic industry - Why the organic industry is growing  - How to find careers in organics  Learn more about QCS on their website: https://qcsinfo.org/ Support the show

Gary Leclerc is well known online for being the founder of Stripwell with their healthy and non-flammable QCS vintage & antique furniture stripper! Gary has also been in the vintage furniture restoration business for 25 years.  A WORD FROM OUR HOST - GARY LECLERC Hi friends! Gary here! Thanks for checking out the Flipstoration podcast. If what we're doing resonates with you, please do us a big favor by subscribing and leaving a short review/rating. That would mean the world to us! Also, feel free to send us a message or leave a comment about other topics you would love to hear on the Flipstoration Podcast. Thanks guys! ABOUT THE FLIPSTORATION PODCAST Hosted by: Gary LeClerc Sponsored by: Stripwell The Flipstoration Podcast is dedicated to the stories of those who strip, sand, finish and repeat. Whether you're into furniture flipping as a hobby, a side-income, or for restoring the purity of an antique or vintage piece - welcome to the Flipstoration nation! Be sure sure to check out our sponsor Stripwell on social media @stripwell or visit their website - https://www.stripwell.com

Chris Bishop's latest Quantum Tech Pod with Eric Holland, Director, Strategic Growth Initiatives, Quantum Engineering Solutions at Keysight Technologies is live! Eric grew up in a small town in New Hampshire and after getting a PhD in physics from Yale, worked as Fermilab's Deputy Director of Quantum Technology as well as Lawrence Livermore National Laboratory's Chief Quantum Hardware & Application Architect. Keysight's Quantum Control System (QCS) is described as the world's first fully digital quantum control solution. We talked about what Bill and Dave might think of their company leading the way in quantum engineering solutions! Check out the conversation. #quantum #Keysight #quantumcontrolsystems #QCS

The Truck N' Hustle "Reset" is Back! This time it's BIGGER in Houston, Texas! Buy Your Tickets Here: Buy Now Special thanks to our sponsors : OTR Capital “To Connect With A Reliable Factoring Partner For Your Trucking Business Needs Contact”: https://otrcapital.com/truck-n-hustle Or Call to speak with an account representative at Call 470 900 3338 GTT Commercial Tires GTT Commercial Tires is a Tire store that is designed with the owner/operator in mind. With Two conveniently located stores in Richmond and Petersburg Virginia and over 2,000 5 star Google reviews they a truly raising the bar and setting a new standard in Tire care Make sure you Call 800 991 6251 to schedule your appointment now! And tell them Truck N Hustle sent you . Exodus Dispatching and Training The Exodus Logistics Learning Center (ELLC) is an online transportation, supply chain and logistics training platform. Our goal is to provide a BASIC-level overview and understanding of the complete supply chain process. Call 757 515 1684 Website Address : https://www.exodusdispatchingandtraining.com/ Email Address : exoduslogisticsllc@yahoo.com or info@exodusdispatchingandtraining.com Xpress Technologies Grow beyond load boards and regain your independence one journey at a time. Xpress Technologies provides carriers like you with consistent and reliable freight that is tailored to meet your specific needs and preferences. Learn more at xpresstechfreight.com or download the Xpress Technologies mobile app today or Call 423 408 6863 Special thanks to our guest Jason Burns, President of the CLDA https://www.dropoff.com/ https://www.linkedin.com/in/jasongburns https://instagram.com/jgbsenior?igshid=YmMyMTA2M2Y= https://www.CLDA.org/ Jason Burns, President of the CLDA & Corporate Development Director of Dropoff Jason Burns is a passionate business leader in the Greater New Orleans community and the Same Day transportation industry. He is a native New Orleanian and a proud graduate of St. Augustine High School, receiving the distinguished “Purple Knight” Award, which is given to the best all-around student. Mr. Burns later became a student-athlete (football) at Vanderbilt University where he was a member of the SEC Honor Roll Team, selected as the recipient of the Head Coach's Dedication Award and he earned a Bachelor of Arts degree in Communication Studies in 2006. Jason later returned to his hometown to assume a leadership role in his family's business enterprises, including Burns Management Group (BMG), Global Parking Systems (GPS) and QCS Logistics (formerly Quick Courier Services, Inc). As a second-generation owner and President of QCS, Mr. Burns led the company's resurgence by developing new service offerings, implementing a new technology platform, and expanding operations into new markets. These initiatives resulted in record growth and QCS was selected to the Inc. 5000 list as one of America's fastest growing companies for four consecutive years. QCS was also recognized as a Top 100 Icon of Industry by ICIC (Initiative for a Competitive Inner City) in 2014. In 2020, QCS was acquired by Dropoff, a national same day delivery company headquartered in Austin, Tx. Mr. Burns is also the managing partner of a boutique investment firm that focuses on commercial real-estate development and private equity investments. He recently founded InPacity, a startup digital freight broker that uses proprietary technology to automatically connect less than truckload (LTL) freight shipments to the available capacity within the final mile carrier network throughout the US.

In this episode, I was able to pick the brain of a professional furniture refinisher with over 24 years of experience! I asked him questions about his process from start to finish on how to safely and properly refinish wood furniture. Gary LeClerc from StripWell shared so many great tips and tricks for getting the best results, including products he uses in his refinishing shop, what to do and what NOT to do when stripping furniture, and more. Read the blog post for this episode, and find links to Gary's product recommendations over in the blog post HERE.Find Gary and QCS at StripWell and on YouTube.Click to send me an email or send the email to serena@thriftdiving.com.Episodes Mentioned I've Been Using Toxic Paint Stripper for Years!Follow me on Instagram @ThriftDiving to stay connected!WANT TO LEARN TO USE POWER TOOLS? I'm creating an online power tools 101 course to help you get over the fear and intimidating of using tools to become empowered with power tools! Sign up here for more info! https://thriftdiving.com/toolsSubscribe to my email list for 5 ebooks, printable, and checklists: https://thriftdiving.com/subscribeSubscribe to my YouTube channel:https://www.youtube.com/user/thriftdivingLet's Connect!BlogYouTubeInstagramFacebookPinterestTikTokTwitterGary LeClerc knows is a passionate artisan and skilled craftsman. He grew up watching and learning from his father who taught him from a very early age what makes a great piece of furniture and how to renew it back to a beautiful and functional state of being. Gary's reputation spread throughout the Northeast as he became known for his ultra-creative and collaborative spirit which would consistently yield showroom quality Mid Century Modern and Scandinavian furniture for his clients.In 2021, Gary launched his new company, Stripwell, and released Stripwell's flagship product QCS Vintage Finish Remover after several intense months of development and testing. QCS stands for Quick, Clean and Safe and it offers refinishers and restorers at any skill level a safe and effective alternative to dangerous stripping chemicals that they would normally use for their projects.Gary hopes to use his nearly 24 years of furniture refinishing and restoration experience to help others and that begins with QCS and making the stripping process a step that no longer has to be scary or intimidating. Follow Stripwell on Instagram, Facebook and YouTube.Support the show

I am delighted to introduce Christopher Mills, a psychotherapist, a family consultant, a supervisor, and a trainer. Christopher began his work alongside family lawyers, helping them to develop skills to help them collaborate across divorce teams. In 2009, he made "Deadlock to dialogue". It was a film, an unrehearsed role-play combining the skills of mediation and psychotherapy when working with separating couples. His interest in mediation around childcare disputes led him to write "The complete guide to divorced parenting", a strong advocate of the need for lawyers to receive more support in their work with family trauma. He became the UK's first professional to offer specific regular supervision for family lawyers and QCs. About six months ago, I was lucky enough to work with this community in Australia as well. And they bear a huge burden when they act on behalf of their clients in these cases. Deep listening podcast listeners have asked if I could do an episode on how to listen in conflict through the lens of relationships.

At the start of 2022, we bring you a series of episodes that pull together the five most interesting predictions we found in multiple areas in tech. Today we look at high-performance computing, in which the processing power of a billion-billion calculations per second is close to reality. As to quantum computing, real-world problem solving is still far away, experts say. 1. High-performance computing on the cloud will go mainstream High-Performance Computing (HPC) in the cloud has reached the mainstream, according to a report by Market Watch, which projects that the market for cloud HPC will rise from $6.9 billion in 2020 to $146 billion by 2027. The major factors driving the growth of the cloud HPC market are - complex applications management, the emergence of the big data market, & the adoption of the pay-as-you-go model. IBM, Microsoft, Google, Dell, Amazon Web Services (AWS), Penguin Computing, Sabalcore Computing, Adaptive Computing, Gompute, & Univa Corporation are among the companies leading the market. 2. And so HPC-as-a-service will find traction Many vendors have moved from selling equipment to providing HPCaaS, & its rise is linked to the emergence of the cloud as an HPC solution, according to Verdict. The trend towards HPCaaS is, therefore, benefitting cloud players such as Amazon Web Services (AWS), Google, & Alibaba although traditional HPC vendors are also offering HPCaaS. HPCaaS can be a compelling option for end-users as it puts intense data processing & workloads that require high-performance within reach of companies that lack the necessary capital to hire skilled staff & invest in hardware. HPCaaS brings HPC capabilities to those companies that cannot afford to develop HPC knowledge & infrastructure in-house. 3. Exascale HPC will arrive The high-performance computing (HPC) industry for a decade has been planning for the arrival of exascale systems—supercomputers that can process at least one exaflop or a quintillion (a billion billion) calculations per second. After years of planning, innovations & missed deadlines, the world is ready to fully embrace exascale computing, according to The New Stack. In the US, the first of three planned exascale systems—Frontier, which will be powered by AMD Epyc processors & Radeon Instinct MI200 GPUs—is being assembled at the Oak Ridge National Laboratory & is expected to deliver a performance of 1.5 exaflops. On the heels of that will come Aurora, which will run on Intel's new 4th Generation Xeon Scalable Sapphire Rapids CPUs & Xe-HPC Ponte Vecchio GPUs. It's expected to be completed later in 2022 at the Argonne National Lab. 4. Quantum computing will continue baby steps As to quantum computing, the technology is steadily improving, but it will likely continue to boast more media coverage than practical applications in 2022, experts at consultancy Deloitte predict. Fewer than a dozen companies worldwide will be using QCs as part of their day-to-day operations & only for a limited number of use cases, mainly around optimisation problems. The 2022 revenues for QC hardware, software, & QC-as-a-service will likely be less than $500 million. 5. Investments in QC will likely remain strong Investor interest will likely continue to be strong, according to Deloitte. VCs invested more than $1 billion into the sector in 2021, & one company even went public with a multibillion-dollar valuation. Further, investment in quantum by governments, including China, India, Japan, Germany, Netherlands, Canada, & the US, will likely bring the total to more than $5 billion for the year, Deloitte estimates.

Today's episode is answering the questions from the comments in the Facebook group and some comments and questions from discord... Facebook.com/groups Discord.gg/ADHDcoin This was fun and we will do this more often as the questions ranged from quantom computing to the basics of buying and selling of NFTS! Please keep the questions coming and stay tuned for future episodes like this one.  The 11 questions we covered were: Who maintains and runs the Blockchain computer network and how does it scale? How will quantum computing affect Blockchain? I've heard about security concerns if QC can hack the algorithm but not sure if QCs could solve the environmental/computational problems. What is needed to get crypto and NFT's out of the early adopter phase? I read web3 and Web 3.0 are different things is that true? Where to store and how to buy easier What's up with stupid gas fees? Different ways to create NFTs, pros and cons. I'd like to understand more about the different utilities you can have with NFT's. ART? utility? Tokens? Access passes etc etc. Endless possibility The utility of all of it. I get it at a basic level, but in scrolling, through all the NFT's I don't see anything that interests me. I don't understand the appeal of auto-generated 10,000 different NFT's in a collection - of Apes or Bubble Gum Kids - and trying to figure out where to start in all of this. Isn't it a problem that minting NFT is so expensive for small digital artists? And how we can solve this problem? I've been taking this all in like a firehose the past 5 days - I'm excited to be a part of the 365NFT project. I'd like to know how I can best step up to support the community and also market this opportunity to the thought leaders in my network. Thank you for all that you do Brian. ----- Podcast is sponsored and SuperPOWERED by ADHD coin on Rally.IO.  Make sure to get your ADHD coin and our Mint 365 NFTs at ADHDcoin.com

Quality Certification Services (QCS) is the certification program of Florida Organic Growers (FOG), which began certifying organic growers in 1989 and received its USDA accreditation in 2001. QCS has grown to provide a variety of quality certification and verification options that can help companies market their products as certified organic, promote sustainability as well as enhance global market access from seed to shelf through partnerships, innovations and technology to clients in 39 states and 12 countries. In this episode, hear about: - How QCS got started and how it has evolved - The types of certifications and services QCS offers   - Resources for farmers interested in becoming certified and consumers looking to support organic growers and producers -  What's in store going forward  Learn more about QCS: https://qcsinfo.org Support the show (https://foginfo.org/donate/)

Florida Certified Organic Growers and Consumers Inc. (FOG) was established in 1987 with the mission to support and promote organic, regenerative, and sustainable agriculture. Since then, FOG's staff and programs have grown greatly.  In this episode, hear from FOG staff members Dr. Juan Carlos Rodriguez, Andi Emrich and Kyndra Love, as they discuss the history of FOG and some of its past, present and future projects. Learn about: - Education and outreach initiatives advancing knowledge and resources about organic and sustainable agriculture - Quality Certification Services (QCS), FOG's certification branch - The Florida Farmers' Market Association (FFMA) - Upcoming projects in 2022  Learn more about FOG on our website: https://foginfo.org Learn more about QCS: https://qcsinfo.org Learn more about FFMA: https://farmersmarkettoolkit.org Support the show (https://foginfo.org/donate/)

Chair of the Queensland Clinical Senate (QCS) Dr Alex Markwell walked us through how clinicians have remained connected during COVID-19 through clinical bodies, advocacy and a range of virtual communication methods. Dr Markwell also gave us an overview of how the QCS works and recent and upcoming priorities. Future priorities include continued COVID briefings, clinician engagement and procurement, voluntary assisted dying, virtual care, system reform, and the health impacts of climate change.

In this episode, Andrew and Fahad discuss quantum computers, what they are, how they are different, why they will be game-changing for software, and how technology leaders can begin developing strategies now for quantum computing.Show NotesBackground: Classic computers have bits that are defined by either a zero or a one (binary), however, there are limitations to this as our computing needs become more complex and require more processing power while using less energy.Quantum computing technology is not designed to replace classic computers, but are tools for solving more complex computing problems.What Are They? Quantum computers are more complex than standard binary because they may process any number of quantum bits (Qubits), storing an enormous amount of information while using less energy.It is theorized that RSA, which is a common algorithm for encryption, can be solved in milliseconds, instead of what right now would take hundreds of years.Quantum Supremacy is a task that a quantum computer can do better than a traditional computer which can greatly impact areas like machine learning, life sciences, biology, chemistry, medicine.Should Technology Leaders Already Be Thinking About Quantum Computers? Yes. There may not be a Moore's Law for QC yet, but the technology is constantly evolving so there will be.If there is an innovation explosion in this field, it changes everything, and if you aren't one of the first people there when it happens you're going to lose.Known Issues With Quantum Computing: Quantum mechanics generate a lot of heat and have to be at zero degrees Kelvin (-459 F) in order to be accurate.These computers will not easily transition onto work or home desks since keeping QCs at zero degrees Kelvin is expensive.No real significant case studies exist yet, still too early. Quantum computing is in its own punch-card stage.Current systems such as Bitcoin are not secure enough to handle quantum changes and could create a Quantum Philosopher's Stone.How Will Quantum Change Software Development? Two possible ways: 1) It will change everything and we will have to re-learn everything. 2)We will be building for and using a library of quantum abstracts.It is best to create a road map with this in mind and assess as to whether your goal is to pilot this new technology, roll it out, or simply observe it (which is where QC currently is for most industries).Quantum Computing may even change the landscape of video games and VR gaming.Resources Mentioned:Moore's LawIBM Quantum ComputingAmazon BraketMicrosoft AzureTensorFlowThanks for listening! What did you think about this episode? Drop us a comment and let us know how we're doing.Visit our Insights page to hear some previous episodes of our podcast and our Thoughtful Articles written by The Skiplist Team.We’d love to know what you took away from our conversation. Follow us at @fahsho12 and @andrewwwolfe and share your insights and questions with the #thoughtful software.

In this episode, we're reflecting on our respective personal experiences in the public and private educational systems.Sandstone buildings versus flammable demountables. Early exposure to the opposite sex versus not talking to a woman until the age of 18. An "asterisk" in the HSC versus having four QCs on speed dial.But do elite insular institutions breed a toxic environment, or is that outweighed by the networking opportunities? And what's it like to graduate without trauma?Featuring more incisive social commentary by top Australian comedian (and Christian Brothers school graduate) Luke Heggie.Spicy stings courtesy of audio producer Tim "T-Dog" Eldridge, with graphic design courtesy of Julia Edwards.Follow/engage/send episode ideas to us here:Instagram: https://www.instagram.com/haveagopodcast/FB: https://www.facebook.com/HaveaGoPodcastEmail: haveagopodcast@gmail.comSee omnystudio.com/listener for privacy information.

YouTube: New Discovery #Vatican #GreatPyramid AMAZING NEW DISCOVERY! Vatican geometry built into St. Peter's Square reveals knowledge of the Great Pyramid Queens Chamber Air Shafts hundreds of years before they were discovered! Where did this knowledge come from? Supposedly Waymann Dixon was the first to find these shafts in 1872 and then it took sophisticated 21st Century robots to explore them. There is not specific mention of these QCS anywhere in ancient literature... until the 16th century in one place... here at Vatican City! Stay tuned... Here is the video by Ancient Architects referenced in the video Please join AIP on one of our tours of Egypt!

Season 3, Episode 2 of The People's Project where we discuss: News is coming back to our Facebook feeds An Anti propaganda video Craig Kelly quits the Libs (Scomo the wrecker?) Desperate Victorians turn to dangerous White Knights QCs draft a fantastic Bill Australians find their common sense Parody animation of Godzilla vs King Kong Full episode on Youtube: https://youtu.be/I3wsV233g08 Join the Discernable Crew (email list) to never lose access to our content: https://www.discernable.io/crew Subscribe to Discernable on Youtube: https://www.youtube.com/discernable?sub_confirmation=1 ---------------------------- The QCs wrote draft legislation as an alternative to a State of Emergency extension: https://youtu.be/wBacIi5Uroo Animation by Hupe! Animation: http://www.alviseavati.com/hupeanimation https://youtu.be/w8VLZtL5V04

In this month's General Practice Podcast, Tracy Green, Head of Primary Care talks to Alison Lowerson, QCS's GP Policy Lead.Tracy and Alison will be discussing Appraisals and how these were paused for GPs during the COVID-19 pandemic.This podcast will aim to provide greater insight into the following areas:Why some people want the appraisal process to carry onWhat practices should now do who may have paused their own appraisal processesWhat policies and procedures practices can utiliseWhat we have learnt from talking to GPs, practice managers and the teams

David Limbrick MP joins me to explain the alternatives to Victoria's never ending State of Emergency. Not only is David Limbrick seeking simple amendments to the government's bill, but a highly experienced team of QCs have gone ahead and drafted an alternative Bill that gives the government everything it needs to manage Covid-19 but without the sledgehammer powers is wants. Will the government scuttle these common sense proposals? Watch this 20min episode on Youtube: https://youtu.be/kZaSl_wbHWI

Jack, Geraint and Yair are joined for a very special discussion (the first of two parts - #2 will be on patreon.com/reelpolitik in the next few days) by Nate Bethea, co-host and producer of @hellofawaytodie and our friends at Trashfuture (Nate is @inthesedeserts on Twitter). With the addition of Nate to our roster resulting in a half-Jewish/half-American panel, we discussed being Jewish on the left and (in part 2) recent developments in US politics. Most notably, Nate tells us about his run-ins with the baldest of QCs, and his general experiences with the melt equivalent of the Q lot (dubbed "QCAnon" by RP's own tom disso.)

There has never been a greater need or time to have meaningful and insightful conversations than in 2020. This year has been like no other and the circumstances have shaped and touched everyone lives. In this episode I look back on conversations that I've had for the restore podcast and pull out some of the key salient points that have really resonated with me and hopefully you over this period of time. There has been a great diversity of guests and perspectives and I hope to have captured some of that on this episode. From spoken word poets to health psychologists, to QCs, to retired group captains, to world record breaking rowers to ex-patients of mine and also family members! This is just a snap shot of a bigger and wider conversation that I've had this year. The mandate of this podcast is that it would give back to you and really encourage you in this time of adversity to not only overcome but to live your best life and transcend the circumstances around us. I look forwards to bringing you with me into 2021.

In this month's General Practice Podcast, Tracy Green, Head of Primary Care talks to Alison Lowerson, QCS's GP Policy Lead.Tracy and Alison will be discussing Complaints and will be explaining what Practices should be doing to manage them.After providing a brief overview of the complaints procedure, the Podcast will aim to provide greater insight into the following areas:Complaints handling best practice.The Complaints Standards Framework, a new set of standards for the NHS.Complaints made during the pandemic.Top tips for managing complaints.

In this month's podcast, I'll be talking about dementia with Jackie Pool, QCS's Dementia Care Champion.Dementia is a condition that has touched so many of our lives. It affects 850,000 people in the UK. Astonishingly, according to the Alzheimer's Society, 1 in 6 people over 80 have dementia, and 70 percent of people in care homes live with dementia, or have severe memory problems.Jackie, who recently joined QCS, has worked with people living with dementia for almost 40 years. An occupational therapist, and an acclaimed author in the field of dementia care, Jackie has vast experience having worked in healthcare, social care and in academia.In this Podcast, we'll be focusing on: How GP services can ensure that people living with dementia receive an excellent standard of support.Fresh insight and perspectives on how GPs can best provide support.The role of collaboration and creating more joined-up servicesThe protocols that the CQC expects to be in place.How GPs can not only demonstrate the requisite policies and procedures to a CQC inspector, but also evidence best practice steps that go over and above what is expectedThe crucial role Patient Participation Groups can play in effecting positive change.The importance of creating dementia-friendly GP surgeries by thinking about space and adapting signage and colour schemes.The PAL tool: What is it and how can it make a difference

In this episode we look at law, order and mental health with one of the U.K.s top QCs. Born and bred in Sheffield Gul Nawaz Hussain was the first QC to be appointed in Sheffield for over 15 years and the first ever BAME QC from South Yorkshire. Within the first 3 years of practice he was ranked as a leading barrister by the premiere legal directories The Legal 500 & Chambers Guide to the Bar. Naz has defended in some of the countries most serious criminal trials involving terrorism, war criminals, gang land murders, international drug trafficking, million-pound frauds and serious & historic sexual offences. After 17 years and having consistently demonstrated excellence in his field Naz was appointed Queen's Counsel, also known as taking Silk, cementing his position at the very top of his profession. In this episode we talk about his childhood and relationship with Father. We also look at Naz's mental focus from a young age & how his experience of visiting a steel works & being told he couldn't be a barrister sharpened his focus. We look at imposter syndrome & the interplay between not feeling enough vs acceptance of success/achievement and worthiness. We also examine Naz's history with Thai boxing & the ensuing self-discipline & how this translates to his practice of law. We look at sweating the small stuff' and his attention to detail. We also get Naz's perspective on some of the country's most high-profile cases in terrorism, murder, gang-land violence and sexual offences. We examine what Naz has learnt as a consequence of some extremely difficult cases & mental tribulations in life. I hope you enjoy the episode You can find out more about Naz here: https://bankhousechambers.co.uk/barrister/naz-hussain-qc/ https://www.33bedfordrow.co.uk/people/hussain-gul-nawaz#content/introduction

Our splendid callers...   Liam Greenlaw: https://twitter.com/liamgreenlaw https://www.instagram.com/punk_duck_warlord And ... this here excellent podcast: http://choonsofglory.buzzsprout.com/ -- Craigus Barry: https://theretinalcircus.bandcamp.com/ - you can hear some of his music in the background toward the end of the call. A high quality audio version awaits, go listen now! We mention the band he played with - highly regarded by those in the know - "Matthew Edwards and The Unfortunates": https://matthewedwardsandtheunfortunates.bandcamp.com/album/the-first-song-of-the-revolution -- Mike The Oz Trucker is here: https://twitter.com/theoztrucker He highlights these articles: Judges, QCs raise alarm over Andrews' new emergency powers https://www.afr.com/companies/professional-services/judges-qcs-raise-alarm-over-new-andrews-emergency-powers-20200922-p55xyc Coronavirus was made in a Chinese lab and released ‘intentionally': Whistleblower virologist https://www.skynews.com.au/details/_6191230400001 -- Finally, Tom James is here: https://twitter.com/tomjayauthor And his article, which we discuss, is here: https://medium.com/@TomJames1/egos-icke-and-the-coronavirus-conspiracy-84aecfe6d16b -- Ok, so you get the format? You ring in, or more likely we set up a zoom room or a skype call, and boom I'll pop you on. I edit it a bit but not to any huge degree. Just feels like the right thing to do with this platform at the moment... Hail Eris, All Hail Discordia; The Goddess is coming, rejoice, run away, return!

A group of 14 retired judges and top QCs have written an open letter to Premier Daniel Andrews calling for a rethink of a bill which would grant authorised officers the power to arrest people who they suspect may breach COVID-19 restrictions in the future. See omnystudio.com/listener for privacy information.

As we're all aware, this year, health workers are facing the nightmare scenario of dealing with both flu and Coronavirus at the same time. The government's response has been to launch “the most comprehensive flu programme in UK history”. It announced that it would offer flu vaccinations to 30 million people this winter.  The expanded programme will be available to: people aged between 50 and 64; households of those who are shielding, and; children in their first year of secondary school.What's less clear is how such a large programme will actually be delivered on the ground. There are many unanswered questions, which could create a number of unforeseen compliance challenges. In this episode, Tracy Green, Head of Primary Care at QCS will be discussing some of these compliance challenges with QCS's GP Policy Lead Alison Lowerson.To find out more about QCS' GP Management System please visit: www.qcs.co.uk/gppodcast

The landscape of primary care has altered significantly, and many of the changes practices have made to prioritise patients and protect their staff during the Covid crisis are here to stay. This week's podcast features Practice Manager Kay Keane and QCS Head of Primary Care Tracy Green, who talk through their experiences of the pandemic, how they have worked together to support the implementation of Alvanley Family Practice's new systems of working and their thoughts on where we go from here as life returns to the new normal. Introductions (36 secs)   About Alvanley Family Practice and their practice manager, Kay (1 min 20 secs)   ‘Feed the birds' project (1 min 40 secs)   Further innovation: group consultations (2 mins 57 secs)   The advantages of Zoom (4 mins 2 secs)   Tracy's background and experience (4 mins 15 secs)   What have been the biggest challenges for Alvanley? (5 mins 43 secs)   Increased volume of work versus the need to do things differently (6 mins 42 secs)   Changes to the operating model (7 mins 17 secs)   Which new processes would Kay keep? (8 mins 5 secs)   The effect of rapid changes on team dynamics (9 mins 22 secs)   The loss of in-person contact (9 mins 54 secs)   Has general practice changed for the long term? (10 mins 39 secs)   Partnership working with local providers (11 mins 4 secs)   Have we been boosted in some ways? (11 mins 37 secs)   Maintaining momentum during a crisis (12 mins 41 secs)   The QCS response to Covid (14 mins 5 secs)   Who are QCS and what do they do? (16 mins 4 secs)   Governance and general hints and tips (16 mins 59 secs)   The QCS impact on an individual practice (17 mins 33 secs)   Time for reflection (18 mins 6 secs)   Managing the after effects of such a rapid period of change (19 mins 28 secs)   Lessons learned from Tracy's perspective (20 mins 34 secs)   Further information (21 mins 18 secs)     This week's podcast has been sponsored by Quality Compliance Systems (QCS) QCS are offering a free trial to help support practices in embedding their new procedures and processes following the Covid crisis. To find out more, you can visit their website here Content can also be found via the QCS Facebook general practice discussion group: www.facebook.com/Alvanleyfamilypractice   Additional support in relation to Covid-19 is here              

On this episode we welcome Quality Certification Services (QCS) staff to talk about Organic Certification during the COVID19 pandemic. Our panelists are Beth Rota, policy and quality assurance manager, Brian Rakita, inspection manager, and Ram, CEO of QCS.Ram shares with us that the agricultural sector is holding strong, with some operations even doubling sales since the lock-down started. He also shares his work linking small and medium producers to buyers, improving the distribution system that currently mostly benefits large scale producers. Beth, a member of Accredited Certifiers Association, tells how different certifying bodies are working together to come up with a document that outlines best practices to ensure the integrity of the organic label during these difficult times. You can contact Beth about different certifying bodies' efforts to maintain integrity of the organic label at beth@qcsinfo.org.Brian shares how inspectors have had to adapt to online inspections to maintain the robust USDA organic label. You can contact Brian about remote, online inspections at brian@qcsinfo.org.If you have issues with your operation or would like to learn more about resources available to you, please email education@foginfo.org with your questions. Information can also be found on our website foginfo.org under Florida Farmers Market Association (FFMA) tab. Newsletter and weekly updates provide resources for producers. Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/donate/)

On this episode we welcome Quality Certification Services (QCS) staff to talk about Organic Certification during the COVID19 pandemic. Our panelists are Beth Rota, policy and quality assurance manager, Brian Rakita, inspection manager, and Ram, CEO of QCS.Ram shares with us that the agricultural sector is holding strong, with some operations even doubling sales since the lock-down started. He also shares his work linking small and medium producers to buyers, improving the distribution system that currently mostly benefits large scale producers. Beth, a member of Accredited Certifiers Association, tells how different certifying bodies are working together to come up with a document that outlines best practices to ensure the integrity of the organic label during these difficult times. You can contact Beth about different certifying bodies' efforts to maintain integrity of the organic label at beth@qcsinfo.org.Brian shares how inspectors have had to adapt to online inspections to maintain the robust USDA organic label. You can contact Brian about remote, online inspections at brian@qcsinfo.org.If you have issues with your operation or would like to learn more about resources available to you, please email education@foginfo.org with your questions. Information can also be found on our website foginfo.org under Florida Farmers Market Association (FFMA) tab. Newsletter and weekly updates provide resources for producers. Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/donate/)

In the second of our COVID-19 special podcast roundtables, sponsored by Smooth Digital, we look at Managing in a Crisis. Publishing editor Steve Hemsley is joined by four experts to discuss the management and leadership challenges faced by care homes during the Coronavirus outbreak.Our panel comprises: Nikki Walker, COO at QCS; Fiona Hale, managing director at CoolCare; Sybille Steiner, partner at Irwin Mitchell and Anne Myrup product director at Planday.They discuss:· How to manage a care home in a crisis· What to focus on and how to prioritise· The importance of having a crisis plan now and in the future· Why clear and open communication with all staff is crucial· How digital technology can help managers to lead effectively· Why employment law must not be ignored during a crisis· The importance of data collection so the business continuesTune in today and share our panel’s thought-leadership and insight.Support the show (http://chmonline.co.uk)

In the first of our COVID-19 special podcast roundtables, sponsored by care home marketing experts Smooth Digital, we look at the importance of Infection Control. Our expert panel comprises Philippa Shirtcliffe, head of care quality at Quality Compliance Systems, Jamie Woodhall, technical and innovations manager at Rentokil Specialist Hygiene, Neha Mehta, head of customer success at Sekoia and Lisa Bainbridge, marketing manager at Beaucare Medical.Our experts discuss:· What is good practice when it comes to infection control?· How to obtain and use PPE effectively· Top tips for robust infection control now and in the future· Why infection control must be higher up care homes’ business agenda· How to deal with clinical waste· Cleaning techniques and the benefit of contingency prepping for a potential COVID-19 outbreak · Tips on how to communicate good practice and infection control guidance to carers and other staff using digital technologyJoin us to learn how to ensure your care home has the best infection control policies in place and how the sector can emerge stronger from the current COVID-19 pandemic.Hosted by Care Home Management magazine publishing editor Steve Hemsley.Support the show (http://chmonline.co.uk)

Our guest today is Alane Humrich from Gainesville based Community Weatherization Coalition! Tune in to learn about their work and to find out how you can save water and electricity.Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/donate/)

Our guest today is Alane Humrich from Gainesville based Community Weatherization Coalition! Tune in to learn about their work and to find out how you can save water and electricity.Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/donate/)

If you are man and own a cat, you are a man with a cat. If you are a woman with one, you are a crazy cat lady. Recently the term crazy cat lady has been reclaimed in a positive way on social media but many say it is a pejorative term used against women who break from tradition. Alice Maddicott is the author of Cat Women and writer Kat Brown has two cats, Ambridge and Genevieve and has written about the support they gave her during fertility treatment. Next week 114 new QCs will receive their silks at a ceremony in front of the Lord Chancellor at Westminster Hall. Of those 114 just 30 are women. So what’s holding women back? A children’s nurse on the edge of physical and mental collapse is at the centre of a new novel Rest And Be Thankful. The author, Emma Glass is a paediatric nurse herself so she knows all about hands red raw from washing and how to support grieving parents so why did she decide to write a novel using her experiences? Rough sex is sometimes used as a defence in court cases involving sexual violence. The government says it’s going to look at these rough sex laws as part of the Domestic Abuse Bill, which had its First Reading in the House of Commons last week. Parliament being prorogued and then the election in December delayed the progress of the Bill. To get the latest on the Bill is the MP and Mother of the House, Harriet Harman. Presenter: Jenni Murray Interviewed guest: Alice Maddicott author of Cat Women Interviewed guest: Writer Kat Brown Interviewed guest: Sian Mirchandani QC from 4 New Square Interviewed guest: Rebecca Tuck from Old Square Chambers Interviewed guest: Author Emma Glass Interviewed guest: MP Harriet Harman Producer: Henrietta Harrison

Second part is here! We continue our conversation with Dan and Adam regarding organic certification. On this episode, we touch on common misconceptions surrounding organic certification, transitional organic, and a final rundown on the certification process!Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/donate/)

Second part is here! We continue our conversation with Dan and Adam regarding organic certification. On this episode, we touch on common misconceptions surrounding organic certification, transitional organic, and a final rundown on the certification process!Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/donate/)

On today's episode, Dan Zaman and Adam Maxwell chat with us regarding what it takes to get certified organic, what the label means, and the level of scrutiny they follow. Get your questions answered HERE! Dan and Adam have the appropriate background and extensive training on the certification process, they understand what is behind the label and have complete knowledge on the current NOP regulation. Part 2 to follow next week!Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/get-involved/donate/)Support the show (https://foginfo.org/donate/)

On today's episode, Dan Zaman and Adam Maxwell chat with us regarding what it takes to get certified organic, what the label means, and the level of scrutiny they follow. Get your questions answered HERE! Dan and Adam have the appropriate background and extensive training on the certification process, they understand what is behind the label and have complete knowledge on the current NOP regulation. Part 2 to follow next week!Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/get-involved/donate/)Support the show (https://foginfo.org/donate/)

This week on Fresh Take we chat with Michael Purvis. He serves as a Waste Alternative Specialist for Alachua County Solid Waste & Resource Recovery. Michel grew up in Georgia and after attending UGA he moved to Gainesville, FL to start his journey as a public servant in Alachua County. Tune in to learn about Recycling and the benefits!! Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/get-involved/donate/)Support the show (https://foginfo.org/donate/)

This week on Fresh Take we chat with Michael Purvis. He serves as a Waste Alternative Specialist for Alachua County Solid Waste & Resource Recovery. Michel grew up in Georgia and after attending UGA he moved to Gainesville, FL to start his journey as a public servant in Alachua County. Tune in to learn about Recycling and the benefits!! Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/get-involved/donate/)Support the show (https://foginfo.org/donate/)

It is our pleasure to present our very special guest for today's episode! Anna Prizzia – Director of UF IFAS Field & Fork and Board Member of Working Foods Karissa Raskin – City of Gainesville Civic Collaboration Specialist Yvette Thomas– Planner for the City of Gainesville Different stakeholder groups, UF IFAS Field & Fork, Working Foods, Levin College of Law Conservation Clinic, Food System Collation, local farmers, and others have come together to present a draft on Urban Agriculture. This ordinance has been drafted by different entities around the local food system and it’s your turn to have your voice heard! You can comment on the draft until Feb 21st. Tune in to learn about urban agriculture, it's benefits, and the new draft for the City of Gainesville!Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/donate/)

It is our pleasure to present our very special guest for today's episode! Anna Prizzia – Director of UF IFAS Field & Fork and Board Member of Working Foods Karissa Raskin – City of Gainesville Civic Collaboration Specialist Yvette Thomas– Planner for the City of Gainesville Different stakeholder groups, UF IFAS Field & Fork, Working Foods, Levin College of Law Conservation Clinic, Food System Collation, local farmers, and others have come together to present a draft on Urban Agriculture. This ordinance has been drafted by different entities around the local food system and it’s your turn to have your voice heard! You can comment on the draft until Feb 21st. Tune in to learn about urban agriculture, it's benefits, and the new draft for the City of Gainesville!Fresh Take is your weekly dose of all things related to organic and sustainable living. Join Florida Organic Growers staff and guest experts as we discuss everything you need to know about sustainable living, organic agriculture, and how to make the best lifestyle choices that benefit you and the environment. So, if you’re an eco-warrior, a dedicated farmer, or just someone looking to make more conscious decisions, tune in every Monday to get your Fresh Take. Florida Certified Organic Growers and Consumers, Inc. (FOG) is a 501(c)(3) non-profit established in 1987 as a grassroots organization, formed by those who believe in organic, sustainable, and regenerative agriculture. Our vision is to create a more sustainable and just food system that benefits both consumers and the environment. Quality Certification Services (QCS) has been an industry leader in providing organic, food safety, and ethical certifications since 1989. As an accredited certifying agency, QCS has been meeting the demands of a growing food industry for more than 30 years. QCS is proud to offer organic and food safety certification for crop production, livestock, retail, restaurants, processing and handling, and importer and exporter operations of all sizes. As the largest US-based certification agency on the eastern seaboard, QCS and our staff of highly qualified and dedicated food and agricultural scientists, educators, and regulators, is capable of meeting all certification needs with expertise.Support the show (https://foginfo.org/donate/)

Kirsty Young's castaway is the barrister Michael Mansfield.He is one of Britain's leading QCs - the Birmingham six, the Marchioness disaster, the Stephen Lawrence trial and the death of Jean Charles de Menezes are only a handful of the high profile cases he's been involved in.He describes himself as a 'radical lawyer' and says he's been educated by the cases he's taken on. He has become, he says, increasingly angry and radical over the years. "I do feel that reputation, standing up for principle, is one of the few ways in which a difference can be made." Record: The Goons - What's the Time, Eccles? Book: The Rights of Man by Thomas Paine as his Bible: and The Cairo Trilogy by Naguib Mahfouz Luxury: A drum kit.