Podcasts about delian

This Valentine's Day weekend, we're airing the debut episode of Modern Relationships featuring Varda space founder Delian Asparouhov and repeat M.O.Z. guest Nadia Asparouhova. Delian and Nadia talk about how they make their relationship work, dating in San Francisco, and why overcommunication might do more harm than good. —

Varda Space founder Delian Asparouhov and writer Nadia Asparouhova get surprisingly candid about what makes their relationship work - from their chaotic first date to how they've built a life together while pursuing ambitious work. Turns out: sometimes talking less, not more, is the key to lasting partnership. This is the first episode of Turpentine's newest podcast Modern Relationships, which will feature insights from tech power couples and leading thinkers like Rob Henderson about building strong relationships. Subscribe below: Apple: https://podcasts.apple.com/us/podcast/id1786227593  Spotify: https://open.spotify.com/show/5hJzs0gDg6lRT6r10mdpVg  YouTube: https://www.youtube.com/@ModernRelationshipsPod  —

Twenty Minute VC Key Takeaways  “Extraordinary careers, when you are junior in venture, do not get built sitting behind a desk in an office behind a laptop. You have to be willing to go meet with founders in person, figure out how to understand their business and how to convince them to even spend time with you when you are not one of the big general partners.” – Delian Asparouhov Startups must have a strong vision for the future of the world, and then build towards making that vision the reality Young venture capitalists do not focus enough on differentiation; many young VCs spread themselves too thin by focusing on a multitude of sectors In venture, you have no moat other than your brand; “US dollars” is the product that you deliver – a product that anybody else can deliverThe number one thing that Delian has learned from Peter Thiel:  There is always a way to structure your argument so that you are on the winning side no matter what “People love software because the marginal distribution costs are zero, but perhaps what people need to realize is also that the marginal returns are zero as well because there is no moat.” – Delian Asparouhov The only rule of the Founders Fund is that there are no rules Over the next 100-200 years, our biggest geopolitical and moral crisis is humanity speciating by way of artificial selection pressures (such as embryonic scoring and CRISPR DNA changing) and natural selection pressures (such as humans existing on new frontiers, perhaps in space)Say what you think; it doesn't really matter how society chooses to react to it Read the full notes @ podcastnotes.org Delian Asparouhov is a Partner at Founders Fund and Co-Founder and President of Varda Space Industries, which is building the world's first space factories. At Founders Fund Delian has led deals in the likes of Ramp ($7BN) and Sword Health ($3BN) among others. Before joining Founders Fund, he was a Principal at Khosla Ventures, Head of Growth at Teespring, and Founder of a healthcare company called Nightingale. In Today's Episode with Delian Asparouhov We Discuss: 1. Venture Capital: Winners, Losers and Everyone Else: Who are the Top 3 venture firms in the world today according to Delian? Why does Delian believe that Benchmark are not the firm they were? Who will be the winners in venture in the next 10 years? Who will be the losers in venture in the next 10 years? 2. Inside Founders Fund: What No One Sees: What are the most important and impactful elements of Founders Fund that no one knows about? What does Delian believe that the Founders Fund partnership will strongly disagree with him on? Why does Founders Fund believe the path of most resistance is the best way to make decisions? What single topic has Delian publicly disagreed with Peter Thiel on most? How did it go? 3. What Every Young VC Needs to Know: What are Delian's single biggest tips to young VCs looking to scale the VC ladder today? What are the five core pillars of venture according to Delian? What should young VCs focus on? Why does Delian disagree with Founders Fund partners that "the best founders do not need the help of their VCs?" Does Delian agree with Vinod Khosla that "90% of VCs do detract value?" What are the biggest ways that Delian believes VCs can and do detract value? 4. Europe Will Be Third World, Parenting and Marriage: Why does Delian believe that Western Europe will become like the third world? What are Delian's single biggest tips on finding a life partner? What have been the biggest changes to Delian since becoming a father? What question does no one ask Delian that someone should ask him?  

Twenty Minute VC Key Takeaways  “Extraordinary careers, when you are junior in venture, do not get built sitting behind a desk in an office behind a laptop. You have to be willing to go meet with founders in person, figure out how to understand their business and how to convince them to even spend time with you when you are not one of the big general partners.” – Delian Asparouhov Startups must have a strong vision for the future of the world, and then build towards making that vision the reality Young venture capitalists do not focus enough on differentiation; many young VCs spread themselves too thin by focusing on a multitude of sectors In venture, you have no moat other than your brand; “US dollars” is the product that you deliver – a product that anybody else can deliverThe number one thing that Delian has learned from Peter Thiel:  There is always a way to structure your argument so that you are on the winning side no matter what “People love software because the marginal distribution costs are zero, but perhaps what people need to realize is also that the marginal returns are zero as well because there is no moat.” – Delian Asparouhov The only rule of the Founders Fund is that there are no rules Over the next 100-200 years, our biggest geopolitical and moral crisis is humanity speciating by way of artificial selection pressures (such as embryonic scoring and CRISPR DNA changing) and natural selection pressures (such as humans existing on new frontiers, perhaps in space)Say what you think; it doesn't really matter how society chooses to react to it Read the full notes @ podcastnotes.org Delian Asparouhov is a Partner at Founders Fund and Co-Founder and President of Varda Space Industries, which is building the world's first space factories. At Founders Fund Delian has led deals in the likes of Ramp ($7BN) and Sword Health ($3BN) among others. Before joining Founders Fund, he was a Principal at Khosla Ventures, Head of Growth at Teespring, and Founder of a healthcare company called Nightingale. In Today's Episode with Delian Asparouhov We Discuss: 1. Venture Capital: Winners, Losers and Everyone Else: Who are the Top 3 venture firms in the world today according to Delian? Why does Delian believe that Benchmark are not the firm they were? Who will be the winners in venture in the next 10 years? Who will be the losers in venture in the next 10 years? 2. Inside Founders Fund: What No One Sees: What are the most important and impactful elements of Founders Fund that no one knows about? What does Delian believe that the Founders Fund partnership will strongly disagree with him on? Why does Founders Fund believe the path of most resistance is the best way to make decisions? What single topic has Delian publicly disagreed with Peter Thiel on most? How did it go? 3. What Every Young VC Needs to Know: What are Delian's single biggest tips to young VCs looking to scale the VC ladder today? What are the five core pillars of venture according to Delian? What should young VCs focus on? Why does Delian disagree with Founders Fund partners that "the best founders do not need the help of their VCs?" Does Delian agree with Vinod Khosla that "90% of VCs do detract value?" What are the biggest ways that Delian believes VCs can and do detract value? 4. Europe Will Be Third World, Parenting and Marriage: Why does Delian believe that Western Europe will become like the third world? What are Delian's single biggest tips on finding a life partner? What have been the biggest changes to Delian since becoming a father? What question does no one ask Delian that someone should ask him?  

Twenty Minute VC Key Takeaways  “Extraordinary careers, when you are junior in venture, do not get built sitting behind a desk in an office behind a laptop. You have to be willing to go meet with founders in person, figure out how to understand their business and how to convince them to even spend time with you when you are not one of the big general partners.” – Delian Asparouhov Startups must have a strong vision for the future of the world, and then build towards making that vision the reality Young venture capitalists do not focus enough on differentiation; many young VCs spread themselves too thin by focusing on a multitude of sectors In venture, you have no moat other than your brand; “US dollars” is the product that you deliver – a product that anybody else can deliverThe number one thing that Delian has learned from Peter Thiel:  There is always a way to structure your argument so that you are on the winning side no matter what “People love software because the marginal distribution costs are zero, but perhaps what people need to realize is also that the marginal returns are zero as well because there is no moat.” – Delian Asparouhov The only rule of the Founders Fund is that there are no rules Over the next 100-200 years, our biggest geopolitical and moral crisis is humanity speciating by way of artificial selection pressures (such as embryonic scoring and CRISPR DNA changing) and natural selection pressures (such as humans existing on new frontiers, perhaps in space)Say what you think; it doesn't really matter how society chooses to react to it Read the full notes @ podcastnotes.org Delian Asparouhov is a Partner at Founders Fund and Co-Founder and President of Varda Space Industries, which is building the world's first space factories. At Founders Fund Delian has led deals in the likes of Ramp ($7BN) and Sword Health ($3BN) among others. Before joining Founders Fund, he was a Principal at Khosla Ventures, Head of Growth at Teespring, and Founder of a healthcare company called Nightingale. In Today's Episode with Delian Asparouhov We Discuss: 1. Venture Capital: Winners, Losers and Everyone Else: Who are the Top 3 venture firms in the world today according to Delian? Why does Delian believe that Benchmark are not the firm they were? Who will be the winners in venture in the next 10 years? Who will be the losers in venture in the next 10 years? 2. Inside Founders Fund: What No One Sees: What are the most important and impactful elements of Founders Fund that no one knows about? What does Delian believe that the Founders Fund partnership will strongly disagree with him on? Why does Founders Fund believe the path of most resistance is the best way to make decisions? What single topic has Delian publicly disagreed with Peter Thiel on most? How did it go? 3. What Every Young VC Needs to Know: What are Delian's single biggest tips to young VCs looking to scale the VC ladder today? What are the five core pillars of venture according to Delian? What should young VCs focus on? Why does Delian disagree with Founders Fund partners that "the best founders do not need the help of their VCs?" Does Delian agree with Vinod Khosla that "90% of VCs do detract value?" What are the biggest ways that Delian believes VCs can and do detract value? 4. Europe Will Be Third World, Parenting and Marriage: Why does Delian believe that Western Europe will become like the third world? What are Delian's single biggest tips on finding a life partner? What have been the biggest changes to Delian since becoming a father? What question does no one ask Delian that someone should ask him?  

Delian Asparouhov is a Partner at Founders Fund and Co-Founder and President of Varda Space Industries, which is building the world's first space factories. At Founders Fund Delian has led deals in the likes of Ramp ($7BN) and Sword Health ($3BN) among others. Before joining Founders Fund, he was a Principal at Khosla Ventures, Head of Growth at Teespring, and Founder of a healthcare company called Nightingale. In Today's Episode with Delian Asparouhov We Discuss: 1. Venture Capital: Winners, Losers and Everyone Else: Who are the Top 3 venture firms in the world today according to Delian? Why does Delian believe that Benchmark are not the firm they were? Who will be the winners in venture in the next 10 years? Who will be the losers in venture in the next 10 years? 2. Inside Founders Fund: What No One Sees: What are the most important and impactful elements of Founders Fund that no one knows about? What does Delian believe that the Founders Fund partnership will strongly disagree with him on? Why does Founders Fund believe the path of most resistance is the best way to make decisions? What single topic has Delian publicly disagreed with Peter Thiel on most? How did it go? 3. What Every Young VC Needs to Know: What are Delian's single biggest tips to young VCs looking to scale the VC ladder today? What are the five core pillars of venture according to Delian? What should young VCs focus on? Why does Delian disagree with Founders Fund partners that "the best founders do not need the help of their VCs?" Does Delian agree with Vinod Khosla that "90% of VCs do detract value?" What are the biggest ways that Delian believes VCs can and do detract value? 4. Europe Will Be Third World, Parenting and Marriage: Why does Delian believe that Western Europe will become like the third world? What are Delian's single biggest tips on finding a life partner? What have been the biggest changes to Delian since becoming a father? What question does no one ask Delian that someone should ask him?  

Hosts @kevingibbon (Shyp, Airhouse) @berman66 (Vowel, Nanit) @sm (Winnie)

In this episode of the Crazy Wisdom Podcast, Stewart Alsop interviews Delian Asparouhov, co-founder and president of Varda. They discuss the science and commercial potential of manufacturing pharmaceuticals in microgravity, the regulatory and technical challenges of space missions, the future of space colonization driven by economic activities, and the advancements in propulsion technologies. Delian also shares insights on the importance of the U.S. space economy, the potential of lunar mining, and his long-term vision for space exploration. For more updates on Varda, follow their corporate Twitter at @vardaspace. Check out this GPT we trained on the conversation! Timestamps 00:00:00 - Introduction and initial discussion about pronouncing Delian Asparouhov's last name. Delian talks about the terminology for space laboratory. 00:05:00 - Delian explains the advantages of manufacturing pharmaceuticals in microgravity and the science behind it. Analogy of cooking in a kitchen is used to describe the process. 00:10:00 - Discussion on the historical background of pharmaceutical manufacturing in space. Delian talks about the involvement of NASA and big pharmaceutical companies. 00:15:00 - The transition from proof of concept to commercialization of space manufacturing. Delian explains the regulatory challenges faced with FAA for launching and reentry. 00:20:00 - Coordinating with multiple parties for successful space missions. Discussion about the future potential of landing missions outside the United States, specifically mentioning Australia. 00:25:00 - Delian discusses the current space economy, SpaceX's impact, and the dominance of the United States in mass to orbit. 00:30:00 - The vastness of space and how much space there is for satellites and other objects. Delian mentions the Lagrangian points as useful waypoints in space. 00:35:00 - Speculation about long-term human colonization in space driven by economic activities. Delian talks about the potential of lunar surface mining and manufacturing. 00:40:00 - The possibility of large-scale manufacturing on the moon and the resources available there. Delian explains the importance of economic activity for space colonization. 00:45:00 - Discussion on propulsion technologies, including electric propulsion and the future potential of warp drives. Delian explains the physics behind various propulsion methods. 00:50:00 - Delian's thoughts on the philosophical aspects of the universe and the laws of physics. He reflects on the fortuitous conditions that led to life on Earth. 00:55:00 - The role of quantum mechanics in modern technology. Delian mentions that while quantum mechanics influence technologies like semiconductors, they haven't directly influenced Varda's work yet. Key Insights 1-The Advantages of Microgravity for Pharmaceutical Manufacturing: Delian Asparouhov explains how the microgravity environment of space allows for unique chemical reactions and crystal formations that are impossible on Earth. By removing the influence of gravity, substances can mix and react more uniformly, leading to potentially better and more stable pharmaceutical products. 2-Historical Context and Industry Involvement: The idea of using space for manufacturing isn't new. Delian discusses how major pharmaceutical companies like Merck and Bristol Myers Squibb, as well as NASA, have been experimenting with microgravity for decades. Varda's approach builds on this history but aims to commercialize the process using modern, cost-effective technology. 3-Regulatory Challenges and Achievements: Varda faced significant regulatory hurdles, particularly with the Federal Aviation Administration (FAA), to secure permissions for launching and reentering spacecraft. Delian highlights the complexity of coordinating with multiple parties, including the military and commercial partners, to ensure mission success and safety. 4-The Dominance of the U.S. in the Space Economy: Delian emphasizes that the United States is currently the leader in space activities, contributing the majority of mass to orbit. While other countries like China and India are making strides, the U.S. remains at the forefront due to its regulatory framework and technological advancements. 5-The Future of Space Colonization: Delian envisions a future where economic activities in space, such as those conducted by Varda, drive human colonization. He believes that large-scale, autonomous manufacturing facilities in orbit and on the lunar surface will pave the way for sustainable human presence in space. 6-Innovations in Propulsion Technologies: The discussion covers advancements in propulsion, particularly electric propulsion using ionized particles. Delian mentions a promising startup, MagDrive, which aims to revolutionize space travel with more efficient and powerful propulsion systems, potentially enabling longer and more economical missions. 7-Economic and Environmental Potential of Lunar Resources: The moon's unique geological features and lack of tectonic activity make it a rich source of raw materials, including water ice and rare earth minerals. Delian explains that lunar mining could support space-based industries and reduce the costs associated with launching materials from Earth, ultimately fostering a robust lunar economy.

On this episode of the World Class Podcast, we sit down with one of the most ambitious entrepreneurs of our generation and the world‘s first "space drug dealer”. Delian Asparouhov is a partner at Founders Fund, as well as the cofounder and chairman of Varda, a revolutionary company building pharmaceuticals infrastructure in outer-space to advance humankind here on earth. In this conversation, we discuss how to accomplish Elon Musk-level moonshot goals, how to assemble World Class teams to make those goals reality, and Delian's advice on how to be fulfilled along the journey.

Right on the heels of their $90M funding round, this week's Pathfinder spotlights Varda and its cofounders, Will Bruey (CEO) and Delian Asparouhov (President). The LA-based startup harnesses microgravity for pharmaceutical development and manufacturing. In its latest mission, the company successfully processed ritonavir, a crucial antiviral drug utilized in HIV/AIDS treatment.In addition to Varda's origin story and the Series B fundraise, Mo, Will, and Delian discuss:Varda's commercialization strategyThe business case for in-space manufacturingThe significance of the W-1 missionAdapting to the regulatory environmentMicrogravity formulation optimizationAnd much more…This episode is brought to you by the Italian Trade Agency (ITA). • Chapters •00:00 Intro & ITA Ad01:21 Varda's origin05:40 What are you building?08:17 What does space have to offer for manufacturing?12:00 The business case for space manufacturing18:02 What drugs have been improved in space?19:13 What happened to ZBLAN?20:54 R&D for manufacturing in space22:34 The W-1 mission29:05 Customer traction30:38 Where does Varda's business risk lie?38:22 Competitive landscape39:49 Potential partnerships42:48 Regulatory learnings45:30 The Series B46:57 Use cases beyond pharma48:19 Space stations55:35 Other companies Will is excited about57:22 Where would Delian invest his last space investment? • Show notes •Varda's website — https://www.varda.com/The Return of Ritonavir Paper: https://www.varda.com/papers/1711063046-return-of-the-ritonavir-a-study-on-the-stability-of-pharmaceuticals-processed-in-orbit-and-returned-to-earth.pdfWill's socials — https://twitter.com/WillBrueyDelian's socials — https://twitter.com/zebulgarMo's socials — https://twitter.com/itsmoislamPayload's socials — https://twitter.com/payloadspace / https://www.linkedin.com/company/payloadspacePathfinder archive — Watch: https://www.youtube.com/@payloadspace Pathfinder archive — Listen: https://pod.payloadspace.com/episodes • About us •Pathfinder is brought to you by Payload, a modern space media brand built from the ground up for a new age of space exploration and commercialization. We deliver need-to-know news and insights daily to 19,000+ commercial, civil, and military space leaders. Payload is read by decision-makers at every leading new space company, along with c-suite leaders at all of the aerospace & defense primes. We're also read on Capitol Hill, in the Pentagon, and at space agencies around the world.Payload began as a weekly email sent to a few friends and coworkers. Today, we're a team distributed across four time zones and two continents, publishing five media properties across multiple platforms:1) Payload, our flagship daily newsletter, sends M-F @ 9am Eastern2) Pathfinder publishes weekly on Tuesday mornings (pod.payloadspace.com)3) Polaris, our weekly policy briefing, publishes weekly on Tuesdays4) Payload Research, our weekly research and analysis piece,  comes out on WednesdaysYou can sign up for all of our publications here: https://payloadspace.com/subscribe/

Delian Asparouhov, a Bulgarian-born, self-made software engineer, dives into the rollercoaster of a journey from being an MIT dropout to earning the Thiel Fellowship. Delian discusses his initial reservations about a career in venture capital and how early exposure to the field via an internship at Square, a student-run VC, helped change his mind and led him closer to his purpose. Delian touches on how he accidentally fell into a full-time venture capital role and how, over time, his skepticism ignited into a passion. Delian also covers his experience as a partner at Founders Fund.This episode explores recent pullbacks in the crypto market – and what these changes spell out for investors – but also gets into the space-born industry and Varda, a first-of-its-kind orbital manufacturing platform, where Delian serves as co-founder. Tune in to hear Tom Wallace and Saxon Baum on Skin in the Game. Hosted on Acast. See acast.com/privacy for more information.

In this episode we have special guest, Delian Asparouhov. Delian is the founder of Nightingale and Varda Space Industries. He was offered a Thiel Fellowship at the age of 19 and dropped out of MIT to pursue his dreams. Delian is a brilliant mind, but more than this he is a passionate father. Delian shares his vision for what he sees as a patriotic duty - having babies and building families! We cover a wide range of topics in this episode: space exploration and innovation, founding companies, becoming a father, culture, and so much more! Follow Delian on X: https://x.com/zebulgar?s=20 And check out Varda: https://www.varda.com/

LaBossiere Podcast Delian Asparouhov is the co-founder, President and Chairman of Varda Space Industries, a company building spacecraft to manufacture materials in microgravity that are difficult or impossible to produce on Earth— starting with pharmaceuticals. He's also a Partner at Founders Fund. Previously, he was a principal at Khosla Ventures, head of growth at Teespring, and founder of a healthcare company called Nightingale. Delian is Bulgarian, attended MIT, and likes to ski and play soccer. 0:00 - Intro 3:14 - How Does Innovation Happen? 6:23 - Varda and the No Science Allowed Rule 7:52 - A Primer on Solid State Microgravity Manufacturing 18:25 - Space Industrialization, Trading Posts, and the Chinese and Portuguese Navies 21:13 - Economic Incentives and Future Business Models in Space 24:24 - SpaceX and The Costs of Mass to Orbit 27:45 - Demand for Space Manufacturing and Varda at Scale 33:44 - Manufacturing, Servicing, Machining, and Future Markets for Space 36:42 - Incubating Companies 40:33 - When Would Varda Have Been Started Otherwise? 42:19 - The Hollywood Model of Startups 45:20 - Future of Incubations 47:47 - Media's Role in Technology 50:39 - What Media Inspired Varda's Founding? 52:38 - Talent, Culture, and Cementing Company Trajectory 53:57 - Narratives and Talent Recruitment 55:28 - Traits Delian Looks for in Founders 57:38 - The ‘Why Now' When Investing 1:00:08 - Bring Non-Consensus and Right 1:02:53 - Is Varda Consensus Yet? 1:03:24 - Identifying Non-Consensus Opportunities 1:05:12 - Lessons from Founding and Investing 1:07:40 - What Skill Do You Wish You'd Developed Earlier? 1:10:11 - Immigrant Mentality 1:11:24 - Less Obvious Reasons for Success 1:12:55 - On Speed 1:14:23 - What Should More People Be Thinking About?

LaBossiere Podcast Delian Asparouhov is the co-founder, President and Chairman of Varda Space Industries, a company building spacecraft to manufacture materials in microgravity that are difficult or impossible to produce on Earth— starting with pharmaceuticals. He's also a Partner at Founders Fund. Previously, he was a principal at Khosla Ventures, head of growth at Teespring, and founder of a healthcare company called Nightingale. Delian is Bulgarian, attended MIT, and likes to ski and play soccer. 0:00 - Intro 3:14 - How Does Innovation Happen? 6:23 - Varda and the No Science Allowed Rule 7:52 - A Primer on Solid State Microgravity Manufacturing 18:25 - Space Industrialization, Trading Posts, and the Chinese and Portuguese Navies 21:13 - Economic Incentives and Future Business Models in Space 24:24 - SpaceX and The Costs of Mass to Orbit 27:45 - Demand for Space Manufacturing and Varda at Scale 33:44 - Manufacturing, Servicing, Machining, and Future Markets for Space 36:42 - Incubating Companies 40:33 - When Would Varda Have Been Started Otherwise? 42:19 - The Hollywood Model of Startups 45:20 - Future of Incubations 47:47 - Media's Role in Technology 50:39 - What Media Inspired Varda's Founding? 52:38 - Talent, Culture, and Cementing Company Trajectory 53:57 - Narratives and Talent Recruitment 55:28 - Traits Delian Looks for in Founders 57:38 - The ‘Why Now' When Investing 1:00:08 - Bring Non-Consensus and Right 1:02:53 - Is Varda Consensus Yet? 1:03:24 - Identifying Non-Consensus Opportunities 1:05:12 - Lessons from Founding and Investing 1:07:40 - What Skill Do You Wish You'd Developed Earlier? 1:10:11 - Immigrant Mentality 1:11:24 - Less Obvious Reasons for Success 1:12:55 - On Speed 1:14:23 - What Should More People Be Thinking About?

Keith Rabois is a Managing Director @ Khosla Ventures and one of the most respected venture investors of the last decade. Keith has led investments in Stripe, Faire, Ramp, Affirm and many more. Just last week, Keith announced he would be rejoining Khosla from Founders Fund, where he spent an immensely successful 5 years as a General Partner. Prior to Founders Fund, Keith started his career at Khosla where he spent 6 years and led investments in DoorDash, Opendoor, Webflow and more. In Today's Episode with Keith Rabois We Discuss: 1. The Decision to Rejoin Khosla Ventures: Why did Keith decide to rejoin Khosla Ventures from Founders Fund? What did Keith miss most that Khosla did, that Founders Fund did not? How did Delian take the news? 2. Comparing Two Great Firms: Founders Fund vs Khosla Ventures: Investing Style: How does Keith compare the investing styles when analyzing FF and KV? Price Discipline: Which firm is more price-disciplined? Does price discipline even matter? What are the single biggest mistakes Keith has made on price? How did it change how he invests? Founder Type: What sort of founder would choose KV? What founder would choose FF? How did the depth & quality of investment decision-making compare between KV and FF? 3. What It Takes To Win in Venture in 2024: Liquidity: What have been Keith's biggest lessons on when is the right time to sell positions? Capital Planning: What have been Keith's biggest lessons on the most effective use of reserves? Why does Keith believe if you do not lose some deals as an investor, you are not competing for the right companies? Khosla Ventures recently raised $3BN. How important is the ability to support companies across their lifetime in 2024 vs stage specific? 4. Where is The Best Place to Invest: Why does Keith think seed is the best place to be investing today? Why despite the better risk/reward profile, does Keith think Series A is not the best place to invest? Does Keith believe we will see the return of growth investing in 2024? What does Keith predict for the M&A market in 2024? Did Figma kill all activity? When will the IPO windows open again? Why would Stripe go out this year? 5. Keith Rabois: AMA: Why did Keith not want to start his own fund? Will he ever? What have been Keith's biggest lessons from working with Vinod Khosla and Peter Thiel? What were Keith's biggest lessons from Roelof Botha on what it takes to be an effective board member? How does Keith think about bitcoin in 2024?

Delian Asparouhov is the co-founder, President and Chairman of Varda Space Industries, a company building spacecraft to manufacture materials in microgravity that are difficult or impossible to produce on Earth— starting with pharmaceuticals. He's also a Partner at Founders Fund. Previously, he was a principal at Khosla Ventures, head of growth at Teespring, and founder of a healthcare company called Nightingale. Delian is Bulgarian, attended MIT, and likes to ski and play soccer. 0:00 - Intro 3:14 - How Does Innovation Happen? 6:23 - Varda and the No Science Allowed Rule 7:52 - A Primer on Solid State Microgravity Manufacturing 18:25 - Space Industrialization, Trading Posts, and the Chinese and Portuguese Navies 21:13 - Economic Incentives and Future Business Models in Space 24:24 - SpaceX and The Costs of Mass to Orbit 27:45 - Demand for Space Manufacturing and Varda at Scale 33:44 - Manufacturing, Servicing, Machining, and Future Markets for Space 36:42 - Incubating Companies 40:33 - When Would Varda Have Been Started Otherwise? 42:19 - The Hollywood Model of Startups 45:20 - Future of Incubations 47:47 - Media's Role in Technology 50:39 - What Media Inspired Varda's Founding? 52:38 - Talent, Culture, and Cementing Company Trajectory 53:57 - Narratives and Talent Recruitment 55:28 - Traits Delian Looks for in Founders 57:38 - The ‘Why Now' When Investing 1:00:08 - Bring Non-Consensus and Right 1:02:53 - Is Varda Consensus Yet? 1:03:24 - Identifying Non-Consensus Opportunities 1:05:12 - Lessons from Founding and Investing 1:07:40 - What Skill Do You Wish You'd Developed Earlier? 1:10:11 - Immigrant Mentality 1:11:24 - Less Obvious Reasons for Success 1:12:55 - On Speed 1:14:23 - What Should More People Be Thinking About?

"Boy Delian: An Intimate Conversation with LemonVinyl about his Musical Journey and Latest Single 'Faraway'"

As Medicare looks to drive down medical costs, pharma manufacturing is going beyond global. For years, drug companies have used the ISS to research and develop new discoveries. But until Varda successfully completed a 27-hour experiment in orbit growing a drug used to help treat HIV. Waiting on a reentry license for its first spacecraft, Morgan sits down with co-founders Will Bruey and Delian Asparouhov to discuss in-space manufacturing, hypersonic missile testing, and (unofficially) replicating LK-99—speculated to be a potential superconductor.

As Medicare looks to drive down medical costs, pharma manufacturing is going beyond global. For years, drug companies have used the ISS to research and develop new discoveries. But until Varda successfully completed a 27-hour experiment in orbit growing a drug used to help treat HIV. Waiting on a reentry license for its first spacecraft, Morgan sits down with co-founders Will Bruey and Delian Asparouhov to discuss in-space manufacturing, hypersonic missile testing, and (unofficially) replicating LK-99—speculated to be a potential superconductor.

Delian Asparouhov is the co-founder of Varda Space, the startup that is manufacturing products in space to benefit life on Earth. He is also a partner at Founders Fund. The first 30 minutes of this episode cover all things space: Varda, investing and building in Space, Elon's role in pushing the industry forward, working in highly-regulated industries, inception of ideas. The second 30 minutes go deep into Delian's personal path into venture, lessons from his first company, what personal characteristics define the best founders, lessons he learned from his mentors, which investment sectors he sees as being the next wave, and some fun fast facts. Follow https://twitter.com/TomorrowTalk_ to stay up to date on all the best clips and upcoming episodes! Follow Delian on Twitter: https://twitter.com/zebulgar. Connect with Sabrina on Twitter: https://twitter.com/SabrinaHalper. Engage with HOF on Twitter: https://twitter.com/HOFCapital or visit https://hofcapital.com/. Reach out to Shalper@hofcapital.com with any feedback, requests for guests, or if you're building something to bring the future closer.

This Week in Startups is brought to you by… Vanta. Compliance and security shouldn't be a deal-breaker for startups to win new business. Vanta makes it easy for companies to get a SOC 2 report fast. TWiST listeners can get $1,000 off for a limited time at vanta.com/twist CLA. Innovation takes balance. CLA's CPAs, consultants, and wealth advisors can help you get from startup to where you want to end up. Get started now at CLAconnect.com/tech LinkedIn Jobs. A business is only as strong as its people, and every hire matters. Go to http://linkedin.com/unicorn to post your first job for free. Terms and conditions apply. * Today's show: Varda's Delian Asparouhov is back with Jason to discuss Varda (18:43), his insights on different aspects of venture capital (1:41), the shifts in silicon valley culture (11:56), and much more! Then, Jason is joined by Argyle CEO Maret Thatcher to discuss how her startup is using AR headsets to make construction PMs faster and more efficient. (58:27) * Time stamps: (00:00) Varda President and Co-Founder Delian Asparouhov joins Jason (1:41) Delian's insights on different aspects of venture capital (8:35) Defense tech and silicon valley's aversion to military (10:48) Vanta - Get $1000 off your SOC 2 at https://vanta.com/twist (11:56) The shift in silicon valley culture (14:39) Culture wars and keeping everyone focused (18:43) The inception of Varda (23:15) Varda's first provisions and overall mission (27:14) CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://claconnect.com/tech (28:31) The customer base and transporting cargo into space (33:14) LinkedIn Jobs - Post your first job for free at https://linkedin.com/unicorn (34:30) Proving this is a sustainable business and “induced demand” is this area (47:21) The government's engagement in the startup community (50:53) Progress around the globe and U.S. relationship with China (58:27) Argyle CEO Maret Thatcher joins Jason (1:03:50) Argyle's product and Magic Leap's role (1:07:42) Video examples of the product in the field (1:09:09) The customer base and how designs are rendered (1:22:25) Business model and live demo of UI * Follow Delian: https://twitter.com/zebulgar Check out Varda: https://www.varda.com Follow Maret: https://twitter.com/MaretSheWrote Check out Argyle: https://www.argyle.build * Read LAUNCH Fund 4 Deal Memo: https://www.launch.co/four Apply for Funding: https://www.launch.co/apply Buy ANGEL: https://www.angelthebook.com Great recent interviews: Steve Huffman, Brian Chesky, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland, PrayingForExits, Jenny Lefcourt Check out Jason's suite of newsletters: https://substack.com/@calacanis * Follow Jason: Twitter: https://twitter.com/jason Instagram: https://www.instagram.com/jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Follow TWiST: Substack: https://twistartups.substack.com Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin * Subscribe to the Founder University Podcast: https://www.founder.university/podcast

Last time I remember writing about Varda co-founder and Founders Fund partner Delian Asparouhov, I was giving him a hard time about his subdued impromptu Clubhouse run-in with then San Francisco District Attorney Chesa Boudin who he'd been flaming on Twitter.But since then, Asparouhov has mellowed out online. When I texted him after our podcast recording session and mentioned that his Founders Fund colleague Mike Solana was sassing me on Elon Musk's social networking platform, Asparouhov wrote back, “Bro I'm tryna do 3 jobs over here. I don't have time to pay attention to what Solana is up to.”Besides Varda and Founders Fund, I wondered what the third job was.He texted me back, “Fatherhood.”On the latest episode of the Newcomer podcast Asparouhov and I covered a lot of ground. We talked about Varda's satellite mission and its ambitions to manufacture in space. We discussed SpaceX's reusable rocket and the media conversation around Starship's explosion. Asparouhov mused about UFOs and missions to Mars. It was a wide-ranging conversation about space and technology.The conversation started off digging into Varda's excited research into LK-99.Varda ran an experiment which they initially thought might show verification of room temperature semiconductors.By the time we recorded our conversation, you could tell Asparouhov was more muted about Varda's findings.Later he tweeted, “alas, the rocks we made floated due to iron impurities.”Highlighted ExcerptsThe transcript has been edited for clarity.Eric: What is Varda's focus at the moment?Delian: Our goal is to take some of the research that's been shown on the International Space Station to have a ton of promise in terms of, as we've been talking about, solid state formulation. It turns out solid state formulation is significantly affected by gravity - that may also be true in superconductors. So one day down the line, if somebody does discover these formulations and they're showing issues that we think gravity could actually solve, there's a world where Varda flies a superconductor. You know, four or five years, definitely not anytime soon, given that the biopharma side is so much more preserved currently.Eric: I'm gonna be dumb again. To me, solid state is like hard drives. Is that what you mean by solid state formulation?Delian: If you look at what's happening both in superconductors and what we do in the pharma world, you're taking things that start as very fine grain powders or liquids and making solid state crystalline versions of them. In the pharma world that ends up looking like a little bit of table salt that you take, and it turns out that thing actually has drug cancer molecules and mRNA molecules. In the world of superconductors, it turns into these things that look like, I mean you've seen them on Twitter, they look like these kind of weird half ceramic, half metal objects. So solid state is just the form of the matter. Solid state in particular typically means a larger crystalline lattice structure, not just individual small molecules.Eric: The whole story of milestones you're talking about, what would be viable, reminds me of the SpaceX experience. Where a few months ago one of their rockets blew up. It's so hard as a layperson, even when cheering these things on, to know as an external observer what signs show the company's on track. What was your reaction to media like The New York Times framing the SpaceX explosion super negatively?Delian: I think the layman's view, particularly The New York Times, was clueless and off base. In aerospace, it's easier to publicly verify traction, unlike software where companies just claim things. You can see did the rocket launch? Did the spacecraft enter orbit? Those are physical facts. SpaceX is developing an extremely ambitious new rocket alongside their workhorse Falcon 9 that has flown over 200 times without exploding. This new rocket is riskier but more capable. It's interesting because even though Falcon 9 lands part of itself, it still loses the top section on every flight. So travel is expensive if you had to rebuild the cockpit after every plane flight. This new rocket Elon's making aims to be fully reusable to lower costs.Because it's so ambitious, SpaceX's approach is to test and fly rapidly rather than get stuck analyzing indefinitely. Their early Falcon rockets blew up but they learned. Nobody expected this new rocket to even get off the pad, but it went way further than expected before failing around stage separation. Calling it a failure seems crazy to me given this is the most ambitious project ever. It did way better than anyone thought, proving out concepts. Failures are part of pushing forward ambitiously. The NYT calling it a Space Shuttle-type failure shows cluelessness - this explicitly developmental rocket had no people aboard. To get to safe, you have to start unsafe and prove it out over time.Eric: How much does Varda depend on SpaceX's continued success in bringing down the cost curve? Could Varda work with today's cost of satellite deployment? Or are you counting on further reductions in deployment costs?Delian: At today's launch costs, where we're spending $1.5 to $2 million per flight, that is low enough for us to build a strong business around what we're doing now. So I'd say none of our models or thinking depends on future cost drops. Obviously I'd be thrilled if something like Starship came online, though I think that'll take time. I'd be excited for more players to start landing rockets - no one has really done that yet, even though it's been eight and a half years since SpaceX's first landing. So I'm not counting on it happening soon. We've architected our business so it doesn't depend on further cost reductions.. Get full access to Newcomer at www.newcomer.co/subscribe

This Week in Startups is brought to you by… OpenPhone. Create business phone numbers for you and your team that work through an app on your smartphone or desktop. TWiST listeners can get an extra 20% off any plan for your first 6 months at openphone.com/twist Crowdbotics. Great ideas can change the world, and Crowdbotics is the fastest way to turn those ideas into code. Get a free scoping session for your next big app idea at crowdbotics.com/twist Superside. Design and creative are crucial for growth. Tech companies like Shopify, Amazon, and Meta have found the perfect solution: Superside. Get $2000 off with Superside's Startup Accelerator package superside.com/TWIST * Today's show: Varda CEO Delian Asparouhov and R&D head Andrew McCalip join Jason to break down their recent experiment in replicating the LK-99 room-temp superconductor (4:19), the current state of material science (18;52), what the world would look like if this works (26:34), and more. Then, Krepling's Liam Gerada joins Jason for an update on his business! (40:46) * Time stamps: (00:00) Varda CEO Delian Asparouhov and R&D head Andrew McCalip join Jason (1:21) The LK-99 superconductor and how Varda is involved (4:19) Varda's latest achievements in replicating the LK-99 superconductor (8:05) Is this the real deal or just a strong diamagnetic effect (11:00) OpenPhone - Get 20% off your first six months at https://openphone.com/twist (12:30) Securing the material needed to run these experiments (14:06) The increased interest in Varda and feedback from the community (18:52) The culture shift in the tech industry (25:06) Crowdbotics - Get a free scoping session for your next big app idea at crowdbotics.com/twist (26:34) Brute force science: How innovation emerges and receives funding (30:17) How the venture model has continued to evolve (24:28) Superside - Go to https://superside.com/twist to get $2000 off with Superside's Startup Accelerator package (36:00) Questions from the live audience (40:46) Krepling's Liam Gerada joins Jason for an update on his business! * Check out Varda: https://varda.com Follow Delian: https://twitter.com/zebulgar Follow Andrew: https://twitter.com/andrewmccalip * Read LAUNCH Fund 4 Deal Memo: https://www.launch.co/four Apply for Funding: https://www.launch.co/apply Buy ANGEL: https://www.angelthebook.com Great recent interviews: Steve Huffman, Brian Chesky, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland, PrayingForExits, Jenny Lefcourt Check out Jason's suite of newsletters: https://substack.com/@calacanis * Follow Jason: Twitter: https://twitter.com/jason Instagram: https://www.instagram.com/jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis * Follow TWiST: Substack: https://twistartups.substack.com Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin * Subscribe to the Founder University Podcast: https://www.founder.university/podcast

This month on Episode 47 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the March 31 issue of Circulation Research. We'll also provide an overview of the Compendium on Increased Risk of Cardiovascular Complications in Chronic Kidney Disease published in the April 14 issue. Finally, this episode features an interview with Dr Elizabeth Tarling and Dr Bethan Clifford from UCLA regarding their study, RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels.   Article highlights:   Shi, et al. LncRNAs Regulate SMC Phenotypic Transition   Chen, et al. Bilirubin Stabilizes Atherosclerotic Plaque   Subramaniam, et al. Mapping Non-Obvious cAMP Nanodomains by Proteomics   Compendium on Increased Risk of Cardiovascular Complications in Chronic Kidney Disease   Cindy St. Hilaire:              Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to share three articles selected from our March 31st issue of Circulation Research and give you a quick summary of our April 14th Compendium. I'm also excited to speak with Dr Elizabeth Tarling and Dr Bethan Clifford from UCLA regarding their study, RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels.   So first the highlights. The first article we're going to discuss is Discovery of Transacting Long Noncoding RNAs that Regulates Smooth Muscle Cell Phenotype. This article's coming from Stanford University and the laboratory of Dr Thomas Quertermous. Smooth muscle cells are the major cell type contributing to atherosclerotic plaques. And in plaque pathogenesis, the cells can undergo a phenotypic transition whereby a contractile smooth muscle cell can trans differentiate into other cell types found within the plaque, such as macrophage-like cells, osteoblast-like cells and fibroblast-like cells. These transitions are regulated by a network of genetic and epigenetic mechanisms, and these mechanisms govern the risk of disease.   The involvement of long non-coding RNAs, or Lnc RNAs as they're called, has been increasingly identified in cardiovascular disease. However, smooth muscle cell Lnc RNAs have not been comprehensively characterized and the regulatory role in the smooth muscle cell state transition is not thoroughly understood. To address this gap, Shi and colleagues created a discovery pipeline and applied it to deeply strand-specific RNA sequencing from human coronary artery smooth muscle cells that were stressed with different disease related stimuli. Subsequently, the functional relevancy of a few novel Lnc RNAs was verified in vitro.   From this pipeline, they identified over 4,500 known and over 13,000 unknown or previously unknown Lnc RNAs in human coronary artery smooth muscle cells. The genomic location of these long noncoding RNAs was enriched near coronary artery disease related transcription factor and genetic loci. They were also found to be gene regulators of smooth muscle cell identity. Two novel Lnc RNAs, ZEB-interacting suppressor or ZIPPOR and TNS1-antisense or TNS1-AS2, were identified by the screen, and this group discovered that the coronary artery disease gene, ZEB2, which is a transcription factor in the TGF beta signaling pathway, is a target for these Lnc RNAs. These data suggest a critical role for long noncoding RNAs in smooth muscle cell phenotypic transition and in human atherosclerotic disease.   Cindy St. Hilaire:              The second article I want to share is titled Destabilization of Atherosclerotic Plaque by Bilirubin Deficiency. This article is coming from the Heart Research Institute and the corresponding author is Roland Stocker. The rupture of atherosclerotic plaque contributes significantly to cardiovascular disease. Plasma concentrations of bilirubin, a byproduct of heme catabolism, is inversely associated with risk of cardiovascular disease, but the link between bilirubin and atherosclerosis is unknown.   Chen et el addressed this gap by crossing a bilirubin knockout mice to a atherosclerosis prone APOe knockout mouse. Chen et el addressed this gap by crossing the bilirubin knockout mouse to the atherosclerosis-prone APOE knockout mouse, and used the tandem stenosis model of plaque instability to address this question. Compared with their litter mate controls, bilirubin-APOE double knockouts showed signs of increased systemic oxidative stress, endothelial dysfunction, as well as hyperlipidemia. And they had higher atherosclerotic plaque burden.   Hemeatabolism was increased in unstable plaques compared with stable plaques in both of these groups as well as in human coronary arteries. In mice, the bilirubin deletion selectively destabilized unstable plaques and this was characterized by positive arterial remodeling and increased cap thinning, intra plaque hemorrhage, infiltration of neutrophils and MPO activity. Subsequent proteomics analysis confirmed bilirubin deletion enhanced extracellular matrix degradation, recruitment and activation of neutrophils and associated oxidative stress in the unstable plaque. Thus, bilirubin deficiency generates a pro atherogenic phenotype and selectively enhances neutrophil-mediated inflammation and destabilization of unstable plaques, thereby providing a link between bilirubin and cardiovascular disease risk.   Cindy St. Hilaire:              The third article I want to share is titled Integrated Proteomics Unveils Regulation of Cardiac Monocyte Hypertrophic Growth by a Nuclear Cyclic AMP Nano Domain under the Control of PDE3A. This study is coming from the University of Oxford in the lab of Manuela Zaccolo. Cyclic AMP is a critically important secondary messenger downstream from a myriad of signaling receptors on the cell surface. Signaling by cyclic AMP is organized in multiple distinct subcellular nano domains, regulated by cyclic AMP hydrolyzing phosphodiesterases or PDEs.   The cardiac beta adrenergic signaling has served as the prototypical system to elucidate this very complex cyclic AMP compartmentalization. Although studies in cardiac monocytes have provided an understanding of the location and the properties of a handful of these subcellular domains, an overview of the cellular landscape of the cyclic AMP nano domains is missing.   To understand the nanodynamics, Subramanian et al combined an integrated phospho proteomics approach that took advantage of the unique role that individual phosphodiesterases play in the control of local cyclic AMP. They combined this with network analysis to identify previously unrecognized cyclic AMP nano domains associated with beta adrenergic stimulation. They found that indeed this integrated phospho proteomics approach could successfully pinpoint the location of these signaling domains and it provided crucial cues to determine the function of previously unknown cyclic AMP nano domains.   The group characterized one such cellular compartment in detail and they showed that the phosphodiesterase PDE3A2 isoform operates in a nuclear nano domain that involves SMAD4 and HDAC1. Inhibition of PDE3 resulted in an increased HDAC1 phosphorylation, which led to an inhibition of its deacetylase activity, and thus derepression of gene transcription and cardiac monocyte hypertrophic growth. These findings reveal a very unique mechanism that explains the negative long-term consequences observed in patients with heart failure treated with PDE3 inhibitors.   Cindy St. Hilaire:              The April 14th issue is our compendium on Increased Risk of Cardiovascular Complications in Chronic Kidney Disease. Dr Heidi Noels from the University of Aachen is our guest editor of the 11 articles in this issue. Chronic kidney disease is defined by kidney damage or a reduced kidney filtration function. Chronic kidney disease is a highly prevalent condition affecting over 13% of the population worldwide and its progressive nature has devastating effects on patient health. At the end stage of kidney disease, patients depend on dialysis or kidney transplantation for survival. However, less than 1% of CKD patients will reach this end stage of chronic kidney disease. Instead, most of them with moderate to advanced chronic kidney disease will prematurely die and most often they die from cardiovascular disease. And this highlights the extreme cardiovascular burden patients with CKD have.   The titles of the articles in this compendium are the Cardio Kidney Patient Epidemiology, Clinical Characteristics, and Therapy by Nicholas Marx, the Innate Immunity System in Patients with Cardiovascular and Kidney Disease by Carmine Zoccali et al. NETs Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney disease by Yvonne Doering et al. Accelerated Vascular Aging and Chronic Kidney Disease, The Potential for Novel Therapies by Peter Stenvinkel et al. Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients with Chronic Kidney Disease by Heidi Noels et al. Cardiovascular Calcification Heterogeneity in Chronic Kidney Disease by Claudia Goettsch et al. Fibrosis in Pathobiology of Heart and Kidney From Deep RNA Sequencing to Novel Molecular Targets by Raphael Kramann et al. Cardiac Metabolism and Heart Failure and Implications for Uremic Cardiomyopathy by P. Christian Schulze et al. Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease by Michael Burnier et al. Role of the Microbiome in Gut, Heart, Kidney crosstalk by Griet Glorieux et al, and Use of Computation Ecosystems to Analyze the Kidney Heart Crosstalk by Joachim Jankowski et al.   These reviews were written by leading investigators in the field, and the editors of Circulation Research hope that this comprehensive undertaking stimulates further research into the path flow of physiological kidney-heart crosstalk, and on comorbidities and intra organ crosstalk in general.   Cindy St. Hilaire:              So for our interview portion of the episode I have with me Dr Elizabeth Tarling and Dr Bethan Clifford. And Dr Tarling is an associate professor in the Department of Medicine in cardiology at UCLA, and Dr Clifford is a postdoctoral fellow with the Tarling lab. And today we're going to be discussing their manuscript that's titled, RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels. So thank you both so much for joining me today.   Elizabeth Tarling:             Thank you for having us.   Bethan Clifford:               Yeah, thanks for having us. This is exciting.   Cindy St. Hilaire:              I guess first, Liz, how did you get into this line of research? I guess, before we get into that, I should disclose. Liz, we are friends and we've worked together in the ATVB Women's Leadership Committee. So full disclosure here, that being said, the editorial board votes on these articles, so it's not just me picking my friends. But it is great to have you here. So how did you enter this field, I guess, briefly?   Elizabeth Tarling:             Yeah, well briefly, I mean my training right from doing my PhD in the United Kingdom in the University of Nottingham has always been on lipid metabolism, lipoprotein biology with an interest in liver and cardiovascular disease. So broadly we've always been interested in this area and this line of research. And my postdoctoral research was on atherosclerosis and lipoprotein metabolism. And this project came about through a number of different unique avenues, but really because we were looking for regulators of LDL biology and plasma LDL cholesterol, that's sort of where the interest of the lab lies.   Cindy St. Hilaire:              Excellent. And Bethan, you came to UCLA from the UK. Was this a topic you were kind of dabbling in before or was it all new for you?   Bethan Clifford:               It was actually all completely new for me. So yeah, I did my PhD at the same university as Liz and when I started looking for postdocs, I was honestly pretty adamant that I wanted to stay clear away from lipids and lipid strategy. And then it wasn't until I started interviewing and meeting people and I spoke to Liz and she really sort of convinced me of the excitement and that the interest and all the possibilities of working with lipids and well now I won't go back, to be honest.   Cindy St. Hilaire:              And now here you are. Well-   Bethan Clifford:               Exactly.   Cindy St. Hilaire:              ... congrats on a wonderful study. So LDLR, so low density lipoprotein receptor, it's a major determinant of plasmid LDL cholesterol levels. And hopefully most of us know and appreciate that that is really a major contributor and a major risk for the development of atherosclerosis and coronary artery disease. And I think one thing people may not really appreciate, which your study kind of introduces and talks about nicely, is the role of the liver, right? And the role of receptor mediated endocytosis in regulating plasma cholesterol levels. And so before we kind of chat about the nitty-gritty of your study, could you just give us a brief summary of these key parts between plasma LDL, the LDL receptor and where it goes in your body?   Elizabeth Tarling:             Yeah. So the liver expresses 70% to 80% of the body's LDL receptor. So it's the major determinant of plasma lipoprotein plasma LDL cholesterol levels. And through groundbreaking work by Mike Brown and Joe Goldstein at the University of Texas, they really define this receptor mediated endocytosis by the liver and the LDL receptor by looking at patients with familial hypercholesterolemia. So those patients have mutations in the LDL receptor and they either express one functional copy or no functional copies of the LDL receptor and they have very, very large changes in plasma LDL cholesterol. And they have severe increases in cardiovascular disease risk and occurrence and diseases associated with elevated levels of cholesterol within the blood and within different tissues. And so that's sort of how the liver really controls plasma LDL cholesterol is through this receptor mediated endocytosis of the lipoprotein particle.   Cindy St. Hilaire:              There's several drugs now that can help regulate our cholesterol levels. So there's statins which block that rate limiting step of cholesterol biosynthesis, but there's this new generation of therapies, the PCSK9 inhibitors. And can you just give us a summary or a quick rundown of what are those key differences really? What is the key mechanism of action that these therapies are going after and is there room for more improvement?   Bethan Clifford:               Yeah, sure. So I mean I think you've touched on something that's really key about the LDR receptor is that it's regulated at so many different levels. So we have medications available that target the production of cholesterol and then as you mentioned this newer generation of things like PCSK9 inhibitors that sort of try and target LDL at the point of clearance from the plasma.   And in response to your question of is there room for more regulation, I would say that given the sort of continual rate of increased cholesterol in the general population and the huge risks associated with elevated cholesterol, there's always capacity for more to improve that and sort of generally improve the health of the population. And what we sort of found particularly exciting about RNF130 is that it's a distinct pathway from any of these regulatory mechanisms. So it doesn't regulate the level of transcription, it doesn't regulate PCSK9. Or in response to PCSK9, it's a completely independent pathway that could sort of improve or add to changes in cholesterol.   Cindy St. Hilaire:              So your study, it's focusing on the E3 ligase, RNF130. What is an E3 ligase, and why was this particular one of interest to you? How did you come across it?   Elizabeth Tarling:             is predTates Bethan joining the lab. This is, I think, again for the listeners and those people in training, I think it's really important to note this project has been going in the lab for a number of years and has really... Bethan was the one who came in and really took charge and helped us round it out. But it wasn't a quick find or a quick story. It had a lot of nuances to it. But we were interested in looking for new regulators of LDL cholesterol and actually through completely independent pathways we had found the RNF130 locus as being associated with LDL cholesterol in animals. And then it came out in a very specific genome-wide association study in the African American care study, the NHLBI care study. And so really what we started looking at, we didn't even know what it was.   Elizabeth Tarling:             So we asked ourselves, well what is this gene? What is this protein? And it's RNF, so that's ring finger containing protein 130 and ring stands for really interesting new gene. Somebody came up with the glorious name. But proteins that contain this ring domain are very characteristic and they are E3 ubiquitin ligases. And so they conjugate the addition of ubiquitin to a target protein and that signals for that protein to either be internalized and/or degraded through different decorative pathways within the cell. And so we didn't land on it because we were looking at E3 ligases, we really came at it from an LDL cholesterol perspective. And it was something that we hadn't worked on before and the study sort of blossomed from there.   Cindy St. Hilaire:              That's amazing and a beautiful, but also, I'm sure, heartbreaking story because these long projects are just... They're bears. So what does this RNF130 do to LDLR? What'd you guys find?   Bethan Clifford:               As Liz said, this is a long process, but one of the key factors of RNF130 is it's structurally characteristically looked like E3 ligase. So the first thing that Liz did and then I followed up with in the lab is to see is this E3 ligase ubiquitinating in vitro. And if it is going to ubiquitinate, what's it likely to regulate that might cause changes in plasma cholesterol that would explain these human genetic links that we saw published at the same time.   And so because the LDL cholesterol is predominantly regulated by the LDL receptor and the levels of it at the surface of the parasites in the liver, the first question we wanted to see is does RNF130 interact in any way with that pathway? And I'm giving you the brief view here of the LDL receptor. We obviously tested lots of different receptors. We tested lots of different endocytose receptors and lipid regulators, but the LDL receptor is the one that we saw could be ubiquitinated by RNF130 in vitro. And so then we wanted to sort of go on from there and establish, okay, if this E3 ubiquitin ligase, is it regulating LDL receptor? What does that mean in an animal context in terms of regulating LDL cholesterol?   Cindy St. Hilaire:              Yeah, and I guess we should also explain, ubiquitination, in terms of this receptor, and I guess related to Goldstein and Brown and receptor mediated endocytosis, like what does that actually mean for the liver cell and the cholesterol in the LDLR that is binding the receptor?   Bethan Clifford:               So yes, ubiquitination is a really common regulatory mechanism actually across all sorts of different cells, all sorts of different receptors and proteins. And basically what it does is it signals for degradation of a protein. So a ubiquitin molecule is conjugated to its target such as in our case the LDL receptor and that ubiquitin tells the cell that this protein is ready for proteasomal degradation. And that's just one of the many things ubiquitination can do. It can also signal for a trafficking event, it can signal for a protein to protein interaction, but it's most commonly associated with the proteasomal degradation.     Cindy St. Hilaire:              So in terms of... I guess I'm thinking in terms of PCSK9, right? So those drugs are stemming from observations in humans, right? There were humans with gain and loss of function mutations, which caused either more or less of this LDLR receptor internalization. How is this RNF130 pathway different from the PCSK9 activities?   Elizabeth Tarling:             Yeah, so PCSK9 is a secreted protein, so it's made by hepatocyte and actually other cells in the body and it's secreted and it binds to the LDL particle, LDL receptor complex, and signals for its internalization and degradation in the proteasome. So this is not ubiquitination event, this is a completely different trafficking event. And so the RNF130, actually what Bethan showed, is it directly ubiquitinates the LDL receptor itself, signaling for an internalization event and then ultimately degradation of the LDR receptor through a decorative pathway, which we also define in the study.   So these are two unique mechanisms and actually some key studies that we did in the paper were to modulate RNF130 in animals that do not have PCSK9. And so in that system where in the absence of PCSK9 you have a lot of LDR receptor in the liver that's internalizing cholesterol. What happens when you overexpress RNF130? Do you still regulate at the LDL receptor? And you absolutely do. And so that again suggests that they're two distinct mechanisms and two distinct pathways.   Cindy St. Hilaire:              That was one thing I really loved about your paper is every kind of figure or section, the question that would pop up in my head, even ones that didn't pop in my head were beautifully answered with some of these really nice animal models, which is never an easy thing, right? And so one of the things that you brought up was difficulty in making one of the animal models. And so I'm wondering if you could share a little bit for that challenge. I think one thing that we always tend to hide is just science is hard and a lot of what we do doesn't work. And I really think especially for the trainees and really everyone out there, if we kind of share these things more, it's better. So what was one of the most challenging things in this study? And I guess I'm thinking about that floxed animal.   Elizabeth Tarling:             Yeah, so I'll speak a bit about that and then I'll let Bethan address because she was really the one on the ground doing a lot of the struggles. But again, we actually weren't going to include this information in the paper. And upon discussion and actually prompted by the reviewers of the paper and some of the questions that they asked us, we realized, you know what? It's actually really important to show this and show that this happens and that there are ways around it.   And so the first story is before Bethan even arrived in the lab, we had purchased embryonic stem cells that were knockout first condition already. And so this is a knockout strategy in which the exon of interest is flanked with lots of P sites so that you can create a flox animal, but also so you can create a whole body knockout just by the insertion of this knockout first cassette.   Elizabeth Tarling:             And so we got those mice actually in the first year of Bethan joining the lab. We finally got the chimeric mice and we were able to stop reading those mice. And at the same time we tried to generate our flox animals so that we could move on to do tissue-specific studies. And Bethan can talk about the pain associated with this. But over two years of breeding, we never got the right genotypes from the different crosses that you need to do to generate the flox animal.   And it was actually in discussions with Bethan where we decided we need to go back. We need to go back to those ESLs that we purchased five years ago and we need to figure out if all of the elements that the quality control step had told us were in place are actually present. And so Bethan went back and sequenced the whole locus and the cassette to figure out what pieces were present and we found that one of the essential locks P sites that's required for every single cross from the initial animal was absent and therefore we could actually never make the mouse we wanted to make.   And so that's sort of just a lesson for people going down that route and making these tools that we need in the lab to answer these questions is that despite paying extra money and getting all of the sort of QCs that you can get before you receive the ESLs, we should have gone back and done our own housekeeping and sort of a long journey told us when we went back that we didn't have what we thought we had at the beginning. And that was a real sticking point as Bethan can-   Cindy St. Hilaire:              Yeah. And so you know you're not alone. My very first postdoc that I did, I went with a mouse that they had also bought and were guaranteed that it was a knockout and it was not. And it is a painful lesson, but it is critical to... You get over it.   So Bethan, maybe you can also tell us a little bit about what are the other kind of next things you tried? You pivoted and you pivoted beautifully because all the models you used I thought were quite elegant in terms of exactly asking the question you wanted to ask in the right cells. So can you maybe explain some of the in vivo models you used for this study?   Bethan Clifford:               Sure, there are definitely a lot. So I mean I think Liz sort of encapsulated the trouble we have with the knockout really succinctly, but actually I want to just take this moment to sort of shout out to another postdoc in the Tarling lab, Kelsey Jarrett, who was really instrumental in the pivoting to a different model. So for the knockouts when we sort of established we didn't have exactly what we thought we did and then to compound that we also weren't getting the DeLiAn ratios breeding this whole body knockout.   We wanted to sort of look at a more transient knockout model. And that's where Kelsey really stepped in and sort of led the way and she generated AAV-CRISPR for us to target RNF130 specifically in the liver. And that had the added beauty of, one, not requiring breeding to get over this hurdle of the knockout being somewhat detrimental to breeding. But it also allowed us to ask the question of what RNF130 is doing specifically in the liver where the liver regulates LDL receptor and LDL cholesterol.   And so that was one of the key models that really, really helped get this paper over the finish line. But we did a whole barrage of experiments, as you've seen. We wanted to make sure... One of the key facets of the Tarling lab is whenever you do anything, no matter what you show Liz, it will always be, "Okay, you showed it to me one way, now show it to me a different way." Can you get the same result coming at it from different ways? And if you can't, why is that? What is the regulation behind that? And so that's really what the paper is doing is asking the same question in as many ways as we can accurately and appropriately probe what RNF130 does to the LDR receptor.   So we tried gain of function studies without adenovirus overexpression. We tried transient knockdown with antisense oligonucleotides, and then we did, as I said, the AAV-CRISPR knockdown with the help of Kelsey and our whole body knockout. And then we also repeated some of these studies such as the adenovirus and the ASO in specific genetic backgrounds. So in the absence of PCSK9, can we still regulate the LDL receptor? And then we also, just to really confirm this, in the absence of the LDL receptor, do we see a difference? And the answer is no, because this effect was really dependent on that LDL receptor being present. So there was a big combination.   Cindy St. Hilaire:              It was really nice, really a beautiful step-wise progression of how to solidly answer this question. But a lot of, I think, almost all you did was in mice. And so what is the genetic evidence for relevancy in humans? Can you discuss a little bit about those databases that you then went to to investigate, is this relevant in humans?   Bethan Clifford:               I think Liz might be better off answering that question.   Elizabeth Tarling:             And I think this sort of pivots on what Bethan was saying. So when we had struggles in the lab, it was a team environment and a collaboration between people in the lab that allowed us to make that leap and make those next experiments possible to then really answer that question. And to be able to include the antisense oligonucleotides required a collaboration with industry. We were very lucky to have a longstanding collaboration with Ionis, who provided the antisense oligonucleotides.   And for the human genetics side of things, that also was a collaboration with Marcus Seldin, who was a former postdoc with Jake Lusis and is now our PI at UC Irvine. And what he helped us do is dive into those summary level databases and ask from that initial study in the NHLBI care population, do we see associations of RNF130 expression in humans with LDL cholesterol with cardiovascular outcomes. And so one database which I would recommend everybody use, it's publicly available, is the StarNet database. And it's in the paper and the website is there. And that allowed us to search for RNF130.   Elizabeth Tarling:             And what it does is it asks how RNF130 expression in different tissues is associated with cardiometabolic outcomes and actual in CAD cases and controls, so people with and without heart disease. And we found that expression of RNF130 in the liver was extremely strongly correlated with the occurrence of cardiovascular disease in people with CAD. So in cases versus controls. And then we were also able to find many other polymorphisms in the RNF130 locus that were associated with LDL cholesterol in multiple different studies.   And I think the other message from this paper is this, unlike PCSK9 and unlike LDR receptor itself, which are single gene mutations that cause cardiovascular disease, there are many sub genome-wide significant loci that contribute to this multifactorial disease, which is extremely complex. And I think RNF130 falls within that bracket that those sort of just on the borderline of being genome-wide significant still play significant biological roles in regulating these processes. And they don't come up as a single gene hit for a disease, but combinatorialy they are associated with increased risk of disease and they have a molecular mechanism that's associated with the disease. And so that's what Marcus helped us do in terms of the human genetics is really understand that and get down to that level of data.   Cindy St. Hilaire:              Yeah. Yeah, it really makes you want to go back and look at those. Everyone always focuses on that really high peak and those analyses, but what are all those other ones above the noise, right? So it's really important.   Elizabeth Tarling:             I think it's really hard to do that. I think that's one where people... Again, it comes down to team science and the group of people that we brought together allowed us to ask that molecular question about how that signal was associated with the phenotype. I think by ourselves we wouldn't have been able to do it.   Cindy St. Hilaire:              Yeah. So your antisense oligonucleotide experiments, they were really nice. They showed, I think it was a four-week therapy, they showed that when you injected them expression of RNF130 went down by 90%. I think cholesterol in the animals was lowered by 50 points or so. Is this kind of a next viable option? And I guess related to that, cholesterol's extremely important for everything, right? Cell membrane integrity, our neurons, all sorts of things. Is it possible with something that is perhaps really as powerful as this to make cholesterol too low?   Elizabeth Tarling:             I think that what we know from PCSK9 gain and loss of function mutations is that you can drop your plasma cholesterol to very low levels and still be okay because there are people walking around with mutations that do that. I think RNF130 is a little different in that it's clearly regulatory in a homeostatic function in that it's ubiquitously expressed and it has this role in the liver to regulate LDL receptor availability, but there are no homozygous loss of function mutants people walking around, which tells us something else about how important it is in potentially other tissues and in other pathways. And we've only just begun to uncover what those roles might be.   So I think that as a therapy, it has great potential. We need to do a lot more studies to sort of move from rodent models into more preclinical models. But I do think that the human data tell us that it's really important in other places too. And so yeah, we need to think about how best it might work as a therapy. If it's combinatorial, if it's dosed. Those are the types of things that we need to think about.   Cindy St. Hilaire:              Yeah, it's really exciting. Do you know, are there other protein targets of RNF130? Is that related to my next question of what is next?   Elizabeth Tarling:             I mean, so I should point out, so Bethan unfortunately left the lab last year for a position at Amgen where she's working on obesity and metabolic disease. But before she left, she did two very, very cool experiments searching for new targets or additional targets of RNF130. Starting in the liver, but hopefully we'll move those into other tissues. And so she did gain of function RNF130 versus what loss of function we have of RNF130, and she did specific mass spec analysis of proteins that are ubiquitinated in those different conditions. And by overlaying those data sets, we're hoping to carve out new additional targets of RNF130. And there are some, and they're in interesting pathways, which we have yet to completely test, but definitely there are additional pathways, at least when you overexpress and reduce expression. Now, whether they turn out to be, again, bonafide in vivo, actual targets that are biologically meaningful is sort of the next step.   Cindy St. Hilaire:              Yeah. Well, I'm sure with your very rigorous approach, you are going to find out and hopefully we'll see it here in the future. Dr Elizabeth Tarling and Dr Bethan Clifford, thank you so much for joining me today. I really enjoyed this paper. It's a beautiful study. I think it's a beautiful example, especially for trainees about kind of thoroughly and rigorously going through and trying to test your hypothesis. So thanks again.   Elizabeth Tarling:             Thank you.   Bethan Clifford:               Thank you very much.   Cindy St. Hilaire:              That's it for the highlights from the March 31st and April 14th issues of Circulation Research. Thank you for listening. Please check out the Circulation Research Facebook page and follow us on Twitter and Instagram with the handle @CircRes, and #DiscoverCircRes. Thank you to our guests, Dr Liz Tarling and Dr Bethan Clifford.   This podcast is produced by Ishara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, you're on-the-go source for the most exciting discoveries in basic cardiovascular research.   This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.  

Delian Asparouhov is a principal at Founders Fund and the co-founder of Varda Space Industries. In this conversation, we talk about building space factories, what is going on in the venture investing community, why Delian believes more people should be starting tech companies, AI, and bitcoin. This conversation was held at Lyceum Miami. ======================= Pomp writes a daily letter to over 200,000+ investors about business, technology, and finance. He breaks down complex topics into easy-to-understand language while sharing opinions on various aspects of each industry. You can subscribe at https://pomp.substack.com/

Delian Asparouhov is a principal at the Founders Fund and co-founder of Varda Space Industries, a space manufacturing startup. We talked about juggling between a VC and founder role, the science of space manufacturing, future plans, life of a space factory worker, creating zero-gravity on Earth, hiring from SpaceX, superpower of Peter Thiel, and more. SPONSORS BridgeUp: DM me on Twitter to raise $100,000+ in non-dilutive capital Listnr: https://listnr.tech/?via=prashant Dukaan: https://mydukaan.io/ Recast: https://recast.studio/ and use code BMS05 for 5% discount GUEST LINKS Twitter: https://twitter.com/zebulgar?s=20&t=pfJTZ4FToEOJ2NY7gjAt2g LinkedIn: https://www.linkedin.com/in/delian-asparouhov-87447742/ Website: https://varda.com/ CONNECT Prashant Bagga: https://linktr.ee/prashantpbagga Billion Moonshots: https://linktr.ee/billionmoonshots OUTLINE (0:00) - Juggling between VC and founder role (5:18) - Science of space manufacturing (12:45) - Putting Factories in Space (18:30) - Life of a space factory worker (21:09) - Is zero-gravity manufacturing on Earth possible? (27:28) - Hiring from SpaceX's Dragon team (33:29) - Role of NASA in the space economy (37:32) - Economic incentives in the space industry TOP EPISODES 77: Shashank Kumar, Founder of Razorpay [Hindi] 75: Kyla Scanlon, Founder of Bread 74: Adam Jackson, Co-founder of Braintrust 68: Natalie Brunell, Host of Coin Stories Podcast 62: Suumit Shah, CEO of Dukaan [Hindi] Past guests of Billion Moonshots include Shashank Kumar, Suumit Shah, Natalie Brunell, Danielle Strachman, Chirag Taneja, Suhas Motwani, Aditya Mohanty, Jan-Philipp Peters, Mo Islam, Peer Richelsen, Justin Nguyen, Paul Griffiths, Gautam Gupta, Sang Le, Rahul Rana, Grace Ling, Joseph Choi and many more.

Regina Barzilay tells the story of her journey to citizenship and the importance of music in our lives.

What's more effective for startups: An in-person environment or a remote one? And which of these types of work cultures are more likely to IPO? Delian Asparouhov, co-founder of Varda and principal investor at Founders Fund explains why he thinks in-person startups, especially at the product market fit stage, are more likely to be acquired and IPO when the team operates in person. This remote versus in-person debate with Levels CEO Sam Corcos covers the benefits of different types of work environments for junior versus senior people, the generation of ideas and deep work, the level of chaos required at an early-stage startup, and the potential appeal of a remote culture for a broader talent pool. Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on Levels - Inside the Company, where we have in-depth conversations about how the Levels startup team builds a movement from the ground up in the health and wellness tech industry.

We explore space manufacturing, microgravity, and building factories in outer space. We're joined by Delian Asparouhov, Co-Founder of Varda Space Industries. We cover leaning into your superpowers when investing, common mistakes in venture capital, and problem solving with space manufacturing. “Trust is not what makes successful co-founding relationships. Having the world-class skillset that you need to succeed is what will then form that trust that will allow you to succeed.” – Delian Asparahouv  EPISODE GUIDE (LINKS, QUOTES, NOTES, AND BOOKS MENTIONED) https://www.danielscrivner.com/notes/delian-asparouhov1-outlier-academy-show-notes  FULL TEXT TRANSCRIPT https://www.danielscrivner.com/notes/delian-asparouhov-outlier-academy-transcript  CHAPTERS This episode is our definitive guide to space manufacturing and building factories in space. In it we cover: 00:00:00 – Introduction 00:02:43 – Delian's background in robotics and path to entrepreneurship 00:07:32 – Mentorship from Jack Dorsey and Keith Rabois 00:21:43 – Leaning into your superpowers when investing 00:25:01 – Cultivating optimism in investing 00:29:29 – Common mistakes in venture capital 00:33:48 – Incubating a company 00:38:59 – Getting started in the space industry 00:42:09 – What is a space factory? 00:45:38 – Problem solving with space manufacturing 00:51:35 – Exciting changes in the space industry 00:55:43 – Recommended resources in the space industry ABOUT VARDA SPACE INDUSTRIES Varda Space Industries is building the world's first space factories. You heard that right, literally factories in outer space, all for earthbound products. What Varda is building, literally wouldn't have been possible even two, three, maybe five years ago, but as launch costs to get mass up to low earth orbit have come down at an incredible pace, it's unlocked the next wave of innovation, including new players and possibilities like what Varda is building with their space factories. 

We're joined by Mo Islam, Payload's Co-Founder. We cover lessons we can learn from the Apollo space era, why killing them with kindness is the best option, and why founders should stay focused on what they love. “Hubris kills startups and humility saves them. No matter what your success level is or may not be, it's really important to always be humble about what you're building and what you're doing because it can change at the drop of a hat.” – Mo Islam EPISODE GUIDE (LINKS, QUOTES, NOTES, AND BOOKS MENTIONED) https://www.danielscrivner.com/notes/mo-islam-playbook  FULL TEXT TRANSCRIPT https://www.danielscrivner.com/notes/mo-islam-playbook-transcript  CHAPTERS In this episode, we deconstruct Mo Islam's peak performance playbook—from their favorite book to the tiny habit that's had the biggest impact on their life. In it we cover: (00:00:00) – Introduction (00:01:40) – Clearing up misconceptions about space (00:03:06) – Kill them with kindness, embrace the boredom (00:05:30) – Learning from Phillippe Laffont and Engines That Move Markets (00:07:33) – Hubris kills startups; humility saves them (00:09:18) – Focus on what you love (00:12:02) – Learning from the Apollo era (00:13:15) – Relying on to-do lists and the Notes app (00:15:53) – Do what matters, change people's lives for the better ABOUT MO ISLAM Mo Islam is co-founder of Payload, which is building a media empire dedicated to covering the business and policy of space, as in outer space. We discovered Payload and immediately subscribed to their daily newsletter after it was recommended by Delian Asparouhov, co-founder of Varda Space Industries, in Episode 71. We asked Delian what newsletters and websites he used to stay on top of everything going on in space, and he had only one answer: Payload Space. Mo Islam has a fascinating background in finance, having worked at J.P. Morgan and Deutsche Bank before co-founding Payload. In this episode, Mo shares why hubris kills startups and humility saves them, what he's learned from incredible investors like Philippe Laffont at Coatue, and why he loves the book Engines That Move Markets, which we had never heard of but immediately ordered after recording this episode with him.

We explore building a media brand to cover the business and policy of space. We're joined by Mo Islam, Payload's Co-Founder, who talks with us about becoming the number one resource for space industry news. We cover everything from lowering the costs of space travel to why we are in the middle of the next space race. “Very simply, we are living in the next space race, and it's going to have huge implications for the way we built technology, the way we spend dollars in military.” – Mo Islam EPISODE GUIDE (LINKS, QUOTES, NOTES, AND BOOKS MENTIONED) https://www.danielscrivner.com/notes/payload-mo-islam  FULL TEXT TRANSCRIPT https://www.danielscrivner.com/notes/payload-mo-islam-transcript  CHAPTERS This episode is our definitive guide to building a media brand to cover the business and policy of space. In it we cover: (00:00:00) – Introduction (00:02:36) – How Payload focuses on the business and policy of space (00:10:54) – How Elon Musk has changed the space race (00:15:17) – Aerospace and defense go hand in hand (00:18:11) – Earth imaging illuminates the atrocities of war (00:19:36) – We are living in the next space race (00:22:52) – SPACs and space (00:28:57) – How we'll move from government to commercial spending in space (00:33:11) – Reusable second stages and lowering the costs of space exploration (00:36:59) – What scaling Starlink could mean for space travel (00:39:40) – Launching a media brand and the importance of voice (00:43:32) – Making Payload the most important voice in the space discussion (00:51:49) – Learning from feedback and embracing boredom ABOUT MO ISLAM Mo Islam is the co-founder of Payload Space, which is building a media empire dedicated to covering the business and policy of space, as in outer space. We discovered Payload and immediately subscribed to their daily newsletter after it was recommended by Delian Asparouhov, co-founder of Varda Space Industries, in episode 71. We asked Delian what newsletters and websites he used to stay on top of everything going on in space, and he had only one answer: Payload Space.  In this episode, we go deep on why we're at an inflection point when it comes to space and how that was unlocked, at least in the U.S., largely by SpaceX, which has brought down the price to get a unit of mass up to low Earth orbit by order of magnitude. We cover the outsized role the military and defense departments play as customers for space companies, ranging from Earth imaging to satellite manufacturing startups. We talk about the space companies that Mo thinks are the most underrated, as well as how Payload is building a media empire, starting with what Mo calls The Modern Homepage, which is their daily newsletter. We discuss how Payload crafted a compelling voice and editorial style in an old school and relatively stodgy industry, making space cool to read and learn about.

After the battle of Tanagra, Athens was able to focus on pursuing its aims throughout Boeotia, the Gulf of Corinth and the Peloponnese. This saw Athens power and influence grow even more at the expense of Sparta and its allies. However, the disaster that would take place in Egypt for Athens would see them now needing to change their policies to better deal with the crisis that was brewing in the Aegean.One of the first measures taken was to put in place a truce with Sparta, so as to reduce the threat of attack within Greece itself. This would then allow Athens to focus its now reduced resources to defending its control in the Aegean, this being the source of their power. The defeat in Egypt had seen some of the Delian league members view Athens in a weakened state. While, there was the fear Persia would once again campaign into Aegean.Athens would first focus on tightening its grip on the league. They would campaign to force the revolting cities back in as tribute paying members. While then taking measures to ensure it would prove more difficult for future rebellions to take place. These would come in the form of coercion, building relations and economic dependency.The other crisis Athens faced in the Aegean was the renewed threat of Persian actions into the Aegean. To deal with this they would arrange an expedition led by Cimon to the Persian controlled island of Cyprus. Although, the island would remain under Persian control the actions that took place would see what appear to be some sort of peace being made between Athens and Persia. Athens had now dealt with the crisis but matters on the Greek mainland had not been resolved and the truce with Sparta was soon due to expire.Support the show

Delian Asparouhov is the co-founder and CEO of Varda Space, a company that builds manufacturing vessels to design products in space. He is also a Principal at Founders Fund. Connect with Varda Space Website: https://varda.com/ LinkedIn: https://www.linkedin.com/company/varda-space-industries/ Twitter: https://twitter.com/VardaSpace Connect with Homeroom Website: https://www.homeroompodcast.com/ LinkedIn: https://www.linkedin.com/company/homeroomtalks/ Twitter: https://twitter.com/homeroomtalks

Sparta had defeated Athens at the battle of Tanagra in 457 BC, though both armies had taken heavy losses. Both would look to make a temporary truce so that they could regroup without the fear of being attacked while in a vulnerable position. This would see the forces of both Athens and Sparta return to their cities bringing a close to this campaign. However, this would not be the end of hostilities and campaigning for the first Peloponnesian war.Just 62 days after Tanagra, Athens would launch a fresh attack into Boeotian lands where Sparta had been active, with a possible agreement with Thebes. Sparta would remain within their home territory which would see Athens facing Theban and other Boeotian troops during this new campaign. Athens would win a major victory while also taking many cities, which would see them gain much control and influence within Boeotia.This would not be the only campaign launched. A naval campaign would also be arranged which would seem to further Athenian trade connections. There was also an element of gaining some revenge for Tanagra, where Athens would ravage a Spartan port. However, it would appear the main objective would be to establish and secure Athenian trade connections to the west through the Corinthian gulf, dominated by many Peloponnesian league members.These campaigns that would unfold and continue through the next couple of years would see Athen's influence within the Greek mainland increases to new heights. Though, news of the disastrous Egyptian campaign would arrive, seeing Athens having to direct its attention to defending its interests within the Delian league as well as counter the threat of possible hostile Persian moves within the Aegean.Support the show

On memeing Miami onto the tech map with a single tweet Download the Callin app for iOS and Android to listen to this podcast live, call in, and more! Also available at callin.com

In this week's episode of the Red Pill Revolution Podcast, we GO DEEP. We touch on everything from King Charles appointing Prince Andrew; An El Paso Teacher fired for promoting the term MAP, UFOs being sited and tracked over Ukraine, a nursing home apologies for bringing in a stripper, and even the ancient Sumerian Race and their unbelievable technological advances. Subscribe and leave a 5-star review! ----more---- Our website https://redpillrevolution.co/    Protect your family and support the Red Pill Revolution Podcast with Affordable Life Insurance. This is attached to my license and not a third-party ad!   Go to https://agents.ethoslife.com/invite/3504a now!   Currently available in AZ, MI, MO, LA, NC, OH, IN, TN, WV Email austin@redpillrevolution.co if you would like to sign up in a different state   Leave a donation, sign up for our weekly podcast companion newsletter, and follow along with all things Red Pill Revolution by going to our website: https://redpillrevolution.co    ----more----   Full Transcription      Welcome to the revolution. Hello and welcome to red pill revolution. My name is Austin Adams and thank you so much for listening today. I appreciate it so so much. We have some very fun and interesting things to talk about today. Some things about the Royal family on the backs of queen Elizabeth's death last week, some things about. I don't know, strippers at old folks homes. And then we will also talk about a little bit about UFOs, a little bit of everything today. So you are in for it. It's gonna be a great show. Thank you so much for listening. The first thing I need you to do before we jump into it is just go ahead and hit that subscribe button for me. All right. Takes five seconds of your day. It means the world to me. That's all I need you to do right now is hit the five star review button and subscribe takes five seconds. Like I said, if you're on apple podcast, Spotify, leave a review. If you are watching this on YouTube, go ahead and hit that like button wherever you're at. I appreciate you so much. And again, welcome to the revolution. We are going to jump right into it. Here are the articles we're going to discuss a nursing home has apologized after hiring strippers for their residents. . And we will discuss that. We actually have a video today, which you guys are in for a treat for. Um, there's some very, very happy old folks in this old folks home. And when I decide to put myself in one, many, many years from now, I may just have to figure out which one this one was, because it looks like they're having a great time. Um, the next one is discussing that prince, or I'm sorry, not no longer prince king, Charles himself is now, uh, seemingly going to a point prince Andrew into a high level position. And if you don't know anything about prince Andrew, you will in just a few minutes, there's a couple articles that we'll discuss on that. We are also going to talk about the Pakistan, former prime minister getting caught red handed, uh, with some documents. Now, normally I don't really care about the Pakistani former prime minister at all. Uh, but this was a, a pretty interesting one. So, um, we'll find out why he got caught red handed, uh, basically, um,  yeah. Basically putting, uh, documents out there during a legal case that didn't even exist. So we'll discuss that. We will also talk about El Paso, firing a teacher for going and calling pedophiles maps to their students and trying to convince them to do the same. So again, we will discuss all of that in a few more things, including UFOs and China, potentially finding a nuclear fusion fuel with limitless energy from the moon. All right. So lots of interesting stuff, stick around. Thanks for listening. Hit that subscribe button. If you didn't already, I forgive you, but if you don't do it now, I may not. All right. I forgive you, but just hit it. I appreciate it. Sincerely. All right, let's get. Welcome to red pill revolution. My name is Austin Adams. Red pill revolution started out with me realizing everything that I knew, everything that I believed, everything I interpreted about my life is through the lens of the information I was spoon fed as a child, religion, politics, history, conspiracies, Hollywood medicine, money, food, all of it, everything we know was tactfully written to influence your decisions and your view on reality by those in power. Now I'm on a mission, a mission to retrain and reeducate myself to find the true reality of what is behind that curtain. And I'm taking your ass with me. Welcome to the revolution. All right. Let's jump into it. Episode number 44 of the red pill revolution podcast. And I appreciate you more than, you know, the very first article that we are going to jump into today is going to be a nursing home. Apologizing, not sure why after hiring strippers for their residents. So we have heard of drag shows for infants and children, but what we have not heard of yet is strippers for old folks homes. and this is probably my favorite new video. There's a hilarious video making its round of a stripper, basically shaking her boobs  and doing all sorts of things in front of these old, old men and women in their mass. It's quite quite hilarious. So we will watch that in just a. But I do find it interesting, right? The, the, uh, drag show for children is such a hot topic. It seems like there was literally never a drag show for children. Right. Because it's a sexualized show until very, very recently. Um, so, and, and there's probably a very obvious reason why there's absolutely no reason children should be involved in drag shows, you know, but maybe that's me being crazy thinking that we shouldn't sexualize. Toddlers and infants, but who knows? So let's go ahead and watch this video here. It is quite hilarious of this nursing home debacle  and then we'll talk about some of the comments that came up in this, and then we'll move on to some more serious topics. But I thought we, you know, we'll start this one off light today. and I'll kind of talk you through what we are seeing in a, uh, you know, PG 13 fashion here. Although it's not, it's not that wild, you know, you can find it. It's not that crazy, but pretty hilarious stuff. All right, let's go ahead and pull this article or this video up. It seems like it's in a different country, but it's, uh, basically. This young woman, she looks like some type of, I don't know, I don't know if she's Asian or something, but they're speaking a different language and she's literally shaking her butt in front of these old folks on these old folks sitting in their wheelchairs. And there is just this man who is so excited to be there with holding this woman's boobs in her hands, hand. this is comical comical. Now I don't know why this isn't a thing. I think there's a company here. I, I don't know why this is not a thing already. There should absolutely be an entire stripper company. Designed to go to old folks homes. I don't know why we're like thinking that shouldn't be a thing. I don't know why these people feel like the need to apologize for hiring a stripper. Um, the only thing they should be hire, or the only thing they should be apologizing for is not hiring enough strippers. Cuz there was only one there and there's plenty of people to go around. Uh, they should absolutely bring in more people. Um, so , I don't know why they, they feel the need to do this. Now let's look through some of the comments here. Somebody says. Flips sake. They're old. They aren't dead. Yeah, of course. Why wouldn't these people enjoy themselves? You're on your way out. You might as well have a good time. Um,  let's see what somebody else said. This is coming from Reddit, Reddit slash face Palm, and somebody said, are we face palming for the apology? The hiring is exemplary.  uh, the next comment says maybe next time, mail strippers for the ladies too. Maybe that's what they forgot and why they have apologized.  all right. I think that's enough on that topic, but I think it's awesome. 100%. I am absolutely behind the strippers at old folks homes, way, way more than I am behind the children going to drag shows. Right. We see all these like horrific videos of, of literal children going to drag shows and giving money to these men. And in 90% of the time at these drag shows, they are highly unhealthy. And, and must we say overweight, and even in some cases, a Dr. May call them obese, but majority of the time it's obese obese men who are shaking the, what they did not have given to them by God, in front of children, asking them for money for sexual acts in front of. It's like literally one of the most horrific things. And like I said earlier, we didn't see that literally a year ago. We didn't see it at all. There was no drag shows, you know, shaking of, uh, you know, butts in front of children that was found to be acceptable a year ago. It's literally so baffling to me how this even became a conversation that we need to have. Um, and everybody who attends these with their children should absolutely have CPS called in them. Although there's another conversation about whether CPS is literally just designed to traffic, children for profit. Um, I heard somewhere that each child that they actually take away from the children ends up being like a hundred thousand dollars or Mo like it, it might have even been like a million. Um, every time CPS takes a child away from their family, they make money off of it from the, the country, from the state, from the federal government or the state government. They're actually profiting from taking children from their parents. And, you know, we went through a whole, you know, the whole vaccination thing. We had to look at it. Luckily, we're in a state here where they have exemptions for children, surprisingly enough, for in the state that I'm in, but they do, they have exemptions. They even have philosophical exemptions for vaccination, but there has been several, several cases. I did a ton of research on it when we decided not to give our children, the COVID vaccine. Um, for many, many reasons, the first being, it's not a vaccine, um, it's mRNA gene therapy, which has never been done before, you know, do your own research on that and make your own decisions for your own children. Um, but with my children's history and everything else, we decided not to do it. So we had to go and actually physically research what could happen if the state decided to come after us for that and have come to find out we fall under exemptions. Really nice to be in the state. I would never move to a state where that's not the case because they've actually, I looked at all of the laws in our state and I looked at all of the previous legal proceedings in cases against parents for not vaccinating. And there was like nine cases in the last hundred years or 70 years when this became a law where they attempted to do so now luckily a majority of those cases, they did not win and the parents actually ended up winning the case. Um, but just tells you how far the state is willing to go to profit from stealing children from their parents. It's horrible. So, you know, do a little bit of research on that. And I, I think it's, again, worth an episode, almost diving into what CPS actually is, what majority they go after, because it's a lot of times it's directly affecting minority communities, disproportionate. Um, you know, but I digress. So let's go ahead and move on from our nursing home strippers and we'll move into  the Royals family situation this week, uh, queen Elizabeth died. If you were hiding under a rock this week, or you're listening from the future in a time machine. Now, listening back, this is, uh, Wednesday, September 14th, 2022, that this is episode is happening and the, uh, queen died last week after almost 70 years, Ofra allowing prince Charles to become king Charles. Now some of the controversy that's coming up from that is that king Charles now, uh, you know, is now looking to so, so king Charles is now going to appoint prince Andrew to step in for him first, if he is ill or out of the country. That's right. The same prince Andrew, it says who was a close friend of Jeffrey Epstein and used $12 million of tax based income. To settle a sexual assault case with Virginia guff, the same Virginia guff, who was at the Galea Maxwell trial testifying directly. Right. You know that one. So king Charles is going to appoint a literal pedophile to potentially step in from now. We'll actually look into what that means. Um, and, and what the actual title is that he'll be getting. Um, but we'll read some of the comments here. It says he was already a counselor to his mom, queen Elizabeth II. The Regency act of 1937, decides who can be counselors. Apparently there's not a clause that has to do with, you know, paying off children for doing illegal sexual acts on them, you know, and being part of international sex trafficking rings. Maybe that should be a clause. I don't know who am I, although if you go and read the Ashley Biden journal, uh you'll know that. Our royalty, our princes and princes, our presidents and their family are not also immune to these types of acts. Um, but it goes on to say that three of them are non working Royals. Um, you guys need new legislation, so prince Andrew or prince, and can replace Peto prince. Now princess Anne is a, uh, somebody who goes on and say for real princess, Anne is a G does a lot of low profile Royal's work, charity work, zero scandals, not a big spender. Um, I could be propaganda by the news, but she seems humble and hardworking. I think she may have even been the one who was, uh, allowed to stand beside the princess, um, in one of these proceedings for like one of the very first times. Um, but quite interesting. Uh, don't really know why a king of a nation. Potentially put a pedophile in the possession of power, but you know, once you find out that maybe potentially majority of them are culprits in this type of thing, uh, you know, it starts to be much more believable. Now this article goes on to say that king Charles II appoints prince Andrew in new important role. And another article says that prince Andrew can still be deputized for king as counselor of state, but princess Anne can't under new rules. And then, um, we'll go ahead and jump into one of those articles here. So it goes on to say that king, uh, king Charles I third ascended the throne after his late mother queen Elizabeth, the second passed away at her country estate in bald morale Scotland. The 73 year old was officially announced as the nation's new sovereign last Saturday, September 10th. And following his proclamation, the new head of state was supposedly appointed his younger brother, prince Andrew as counselor of state. Robert Peston journalist and political editor for ITV news, posted a thread of tweets explaining the situation. And he says the Monarch points, five counselors of state to stand in for him when he is unwell or out of the UK, Peston began, they are his spouse. Plus the top four in secession to the crown who are age 21 or over these include prince Andrew and his daughter, princess Beatrice. It says that, uh, but not prince and who is probably the most widely respected in all of the Royal family. Many would say, this is not, especially since the 2013 secession of the crown act ended Premo, gen premature. Not sure what that is though. Um, only for those born after 2011, uh, interesting. He says it continues that. So if king Charles were incapacitated, Andrew would step in as king. Not Anne. He ended his thread with the question. Do you think most British people would approve? I would certainly hope not says taken to Twitter. Many users shared their answers to passions questions. One responded, I most certainly would become a Republican under those circumstances. No way would I accept Andrew as a standin for the king? This is nuts. A second person wrote in his first week as king Charles has had two hissy fits about pens, sacked dozens of his staff at Clarence house. And now is rehabilitating prince nons. Good call is your majesty. Yeah, I saw him do that, where he was like sitting there signing documents and like pissed that there was some stuff on the table and like waved in somebody else because how dare he have to move the King's hand to move a, you know, pen off of a desk. Um, it goes on to say that a third waited or wants to wait for an outcome tweeting. Let's see what the actual outcome is. I don't think people will stomach Andrew being in that line. I'm pro monarchy. I may be, it may be a legal glitch or point of clarification may be needed, but certainly needs to be changed. Andrew had also, uh, previously served as this Queen's counselor of state, along with king Charles Prince William and prince Harry. Hmm. Um, so who better to take on the throne  than a potential Jeffrey Epstein associated pedophile literally paid off Virginia guff in a settlement claim during, uh, a legal proceeding to hush hush, the conversation surrounding him sexually assaulting a minor. Hmm. Now that could lead us into our next conversation, which, you know, would be a little bit deeper than that, about this, you know, whole map situation, which we'll get into here in a minute. Um, but let's see if there's any more substance to these articles. I don't know anything about this princess Anne. Um, but it sounds like, you know, maybe she's the one who a lot of people are rooting for, or that other person said maybe I'm being propaganda. You know, I like that word propaganda  that seems like it's a, a very fitting word in these types of situations. Um, but how terrifying is that? That literally not only the king of England, but you know, seeing over Canada, seeing over Australia, seeing over, you know, 14 different Commonwealth, uh, realms is what they referred to it as, um, would potentially be prince Andrew also known as PTO Andrew, because as we've stated, he's a pedophile. I don't know. Quite terrifying. What a horrific PR move by, you know, during all of this. Now I did see something about king Charles. I, I just can't say that seriously, king Charles, I feel like I'm in a Disney movie. It seems so bizarre that we have Kings and Queens and princesses and, you know, Royal family, you know, all based on blood lines. That's the, that's the weird thing about the Royal family is it's literally all based on bloodline. You cannot move your way into a position of power. It's literally a Royal bloodline. And we talked about this an episode ago, where if you go back far enough, according to these, you know, conspiracy theories, you know, even people like Cleopatra. And, uh, there's like basically 12 Royal families that have had these bloodlines go down and down for generations. There's a CIA document about it, which is quite quite interesting. Um, so I'll have to check that out at some point there's like a 217 page book that is, uh, put into the cia.gov. Documents, you can go to Google right now, or even better go to brave search right now and type in CIA Royal bloodlines, FOA, OIA, freedom of information act. And you will find the document that I'm discussing here. Anyways, do some research on that. Happy to discuss it with you All right. Let's move on. Dr. Fauci and ran Paul and here is the clip, uh, but she's had the flu for 14 days. Should she get a flu shot? Well, no. If she got the flu for 14 days, she's as protected as anybody can be. Cuz the best vaccination is to get infected. And if not, if she really has the flu, if she really has the flu. Now, what this is, is this is ran Paul grilling, Dr. Fauci very recently regarding this, like today, I believe it's today. He's showing him on an iPad, the, to his own statements from like a few years ago, saying these things about the flu. Okay. So take that into consideration. When you're listening to this vaccination is to get infected yourself and, uh, but she's had the flu for 14 days. Should she get a flu shot? Well, no. If she got the flu for 14 days, she's just protected as anybody can be. Cuz the best vaccination is to get infected yourself and not get it. If she really has the flu, if she really has the flu, she definitely doesn't need a flu vaccine. If she really has the flu, she should not get it again. No, she doesn't need it because the, it it's the BA it's the most potent vaccination is getting infected yourself. So when we look at this, we wonder, you know, why you seem to really embrace basic immunology back in 2004 and how you, or why you seem to reject it now. And as a matter of fact, Reuter's fact check looked at that and said, Fauci, 2004 comments do not contradict his pandemic shame, actually words don't lie. If you look at the words behind me, we can go over them a little bit at a time. She doesn't need it because the most potent vaccin vaccination is getting infected yourself. It is true. It is true Senator. It is a very potent. Way to protect. But when you're trying to tell us that kids need a third or a fourth vaccine, are you including the variability or the variable of previous infection in the studies? No, you're not. So what I love about that is the fact that Dr. Fauci is just shaking in this piece of paper in his hand, coming from Reuters, like Dr. Fauci, aren't you Mr. Science, aren't you the only person who knows about science in this whole world, didn't you claim to be the, what did they say? If you question Dr. Fauci, you question science itself, like aren't you, the guy, not Reuters, not some random journalist who decided to, you know, try and make the world believe that there three year old needs another vaccination to be safe from a, a thing that literally doesn't even exist today. That, that the CDC itself said, you don't even need the quarantine, even if you have it. Right. But you're sitting there trying to justify it. And not only trying to justify it like Dr. Fauci, do you know that this is not. Facebook jail court. This is literally Senate. This is a Senate hearing, not the hearing on Facebook's fact checking. Right. He literally brought the fact that he brought that piece of paper with him to shake in front of the court. The fact that he did that and said, well, Reuters actually says a journalist with no experience in this says that you are wrong. Like you, you said it with your own words. How can you sit here in front of us and say that Reuters is going to like, um, you know, actually Reuters said that what I meant there is different from what I actually said, no, justify your position. Maybe, maybe you should back it up, not utilize Reuters in a fact checker. Like that's how far off we've gotten. That's how 1984 Orwellian we've gotten is now that somebody's going to sit in front of the Senate and utilize a journalist. Article to try and justify their own statements. So they don't have to back it up. And they're gonna use these like abusive, uh, tactics done by these journalistic companies like Reuters to, to try and Gaslight you into thinking that, oh, I, you know, Reuters knows what I meant, not, not myself. So I'll let them explain it. You know, it's like, no, literally you used your own words there. Like it it's, it's so crazy to see that he went on to, to use Reuters of all things to justify, not even backing it up himself. Like he's literally a, according to him, a scientist. And he can't even justify his own position on a statement that he made of with his own words, saying that you do not need a booster. You don't need a vaccine if you got it, because that's the best protection that you can get is actually getting it right. And not taking that into consideration when you are actually deciding to give children experimental drugs. Right. It's it's so, so wild to see that. But I love the fact that Fauci was shaking on camera. I love that. It makes me feel so warm inside just to know that he was so uncomfortable that his body could not even handle it there. And, and then the  other thing that I want to talk about, and, and I'll talk, touch on this just super, super briefly is that there was a clip going around of. Of an employee from Chick-fil-A employee, a Chick-fil-A employee took down this guy that was committing, like trying to steal the keys of this woman who had this children in her car. If you haven't seen it yet, it's gonna start making its rounds over the next few days. It's it's a Chick-fil-A employee who just jumped at this guy, like completely when he tried to like steal this woman's car with her baby in it, and just like threw him to the ground, stood on top of him and just, you know, my pleasure to him. could you just imagine him whispering that in his ear as he took them to the ground? Just amazing. Unbelievable. Um, but you know, I digress now, the very next. Is going to be Pakistan's former prime minister, Noah Sharif's family have produced documents to prove innocence concerning ownership of properties in London. The documents were signed in 2006, but the Kalibri font used in the document was released in 2007. So basically, uh, the document was dated 2006. And the font that was used in a document was 2007. So it completely showed that he fabricated this document. So we'll get a little bit more context here and then we'll talk about it. Um, it goes on, uh, to say that in July, 2018, um, three members of the family were fined and sentenced to jail Nawaz for 10 years, Miriam for seven. And her husband captains Dar for one year in the event, field department's case, as they could not show that the posh London property had been bought legitimately while Nawaz was sentenced for owning assets beyond income, the other two were held guilty for AB Bement and not cooperating with the prob agency. It was in this case that Miriam had presented a trust deed dated February, 2006 in Microsoft's Calibri font, which became commercially available only in 2007 Noah and his kin were jailed, but in September of 2018, the Islam bad high court ordered their release in suspended their sentence pending final adjudication for the, um, of the appeals against it. Hmm. So there is your. Breakdown  of why we are even discussing a former prime minister of Pakistan. Now, a few of the comments that you'll find on this thread here are a little funny that somebody says, that's why I always stick with times new Roman. Yeah. Just in case you find yourself in a court settlement and you don't want to have to deal with a, you know, great lawyer finding out that the font that you used pre or postdated the document that you signed  or forged even better. Um, . Um, pretty, pretty wild. You know, what, what, what hot water you must find yourself in there to legitimately use font. Like how stupid would you feel right to know that you made that big of a mistake, right. And how easy is it to just, just use time, new Roman, you don't have to get fancy here, guys. We don't need your Colibri. We don't need your comic Sams. We don't need any of that times. New Roman all the way across, you're safe from lawyers coming after you for utilizing the wrong font.  all right. So I found that to be interesting. And let's see if there's anything else of note in here. Um, so somebody says, so that's what good lawyers are for. Yes. That is exactly what good lawyers are for finding out that the person used the wrong. Interesting. All right. Anyways, I won't stick around on that one. I just found that to be quite, quite interesting now on the backs of the prince Charles or king Charles situation, let's go ahead and discuss this. There was an Al Paso teacher who was fired over, telling their students to use maps instead of the word pedophile. Um, for a comment in the classroom that touches off a firestorm says Fox news. We'll go ahead and we'll actually listen to this here. Uh, but we'll listen to where she actually says that to him. And this article even goes as far as showing, um, what the husband commented on a thread in a local Facebook group, which I found to be interesting too. So here is the article. It says Al Paso teachers firing over pedophiles comment in classroom launches, a firestorm response. It goes on to say that El Paso's independent school district board of trustees said the allegation is being investigated thoroughly. An El Paso teacher in Texas was informed of her proposed termination after telling students to call pedophiles, minor attracted persons, according to the city's school district. But some witnesses say her remarks were taken out of context. Now she literally says you shouldn't call them pedophiles. It's O you, we shouldn't make fun of them just because they wanna have sex with a five year old. She literally says to a high school student it's wild. It goes on to say that in an 18, second clip shared on TikTok, the Franklin high school teacher identified as the El Paso teachers Associa, uh, by the El Paso teachers association as Amber Parker, she'll never have a job again, um, can be heard telling students that they're not allowed to label individuals as pedophiles. She reportedly made the comment during a lesson on the play, the crucible. We're not gonna call them. That Parker said in the video, we're gonna call them maps, minor attracted persons. So don't judge people just because they want to have sex with a five-year-old. She says, what in the world kind of world are we coming to? We'll listen to the video in just a second, but it says first came the suspension. Then El Paso's independent school district board of trustees unanimously voted to fire Parker following her remarks on the evening of August 29th, 2022, the El Paso independent school district was made aware of a classroom situation. Impromptly initiated an investigation. Um, after a thorough investigation was conducted on September 6th, 2022, during a special board meeting, the board of trustees approved a decision to notify a Franklin high school teacher of proposed termination. The process will continue in accordance with the Texas education code, any allegation and potential misconduct is investigated thoroughly. And the safety of our students is the top priority as this is a personal matter, no further information will be shared at this time. So it goes on to talk about, um, some students were saying that it was taken out of context and then it gives what her husband actually said. Um, but let's go ahead and listen to this clip. It's again, it's 18 seconds long. And we'll see what this teacher had to say about maps. What? Stop it, Diego. Yeah. We're not gonna call them that. We're gonna call them maps. No mono attracted persons. No. So don't judge people just cuz they wanna have sex with a five year old. Oh, call . That was the perfect cut. You hear the guy go? What the fuck?  that's wild now. Thank the Lord that we're seeing retribution in this case. This is exactly what needs to happen across the board. And thankfully it didn't have to come to school board meetings in this, in this situation. Right? A lot of these situations have come to school board meetings, right? The sex books in children's libraries. Right. We've seen many, many videos about, uh, parents going in speaking up against those videos. Um, there's some crazy, crazy books that they're putting in children's libraries talking literally about sodomy and about sexual positions to five and six year olds in elementary schools. It's horrific, but thankfully, thankfully it didn't have to come to this case, at least as far as I know, it seems as if this school board caught it right away and, you know, surprised surprise they did it in Texas now. Um, I don't see how any of that could have been taken out of context. You can't say, you know, so don't judge people just because they won't to Hey of six, we had the five year old. Yeah, I'm gonna judge you. I'm gonna judge you and I'm gonna do way worse than that to you. If it's somebody that I know I'm gonna do far, far more to you than judge you. Yeah, dude, I'm not even gonna get into it cause that's called implication, but horrific, horrific thing to say, and to say it to an entire class of children to say it to an entire group in a high school setting, what kind of precedent is that setting? You're literally talking to minors saying it's okay. It, it, it's not only okay, but don't even judge those people for doing that to a child for literally putting the child in a position where they're going to be hurt worse than anything you could possibly imagine giving so much trauma for the rest of their lives that they're gonna have to deal with and unpack in a way that somebody who didn't deal with that could never have to imagine, could never have to imagine. And she's sitting in front of an entire school or an entire class of children saying that this should be acceptable and they shouldn't be judged. Not only that, but we're not even gonna use this term in case we hurt their little pedophile feelings. Like what in the world now, um, it goes on to say that the school district board of trustees voted to fire Parker following her remarks on the evening, uh, the El Paso school district was made aware of a classroom situation and promptly initiated an investigation. This is coming from the district's chief communications officer who told Fox news digital after a thorough investigation was conducted on Jan, uh, on September 6th, during a special board meeting, the board of trustees approved a decision to notify the teacher of proposed proposed to termination. The process will continue in accordance with the Texas education code, any allegation and potential misconduct. We already talked about that. Moving on, some students went on to say that her words were taken out of context. The teacher was expressing. This says how it was ridiculous, how they, how we might not be able to call people pedophiles that we will probably have to start calling them maps because is offensive to them. The class agreed. That's not what it sounded like now, if that is what it is, maybe you shouldn't be saying that in a group of high school students. Um, but if you are being sarcastic and then following that clip by saying, yeah, this is disgusting. This is gross. What they're doing, you know, we're absolutely going to call these people pedophiles and we're not gonna give into the woke ideology that is saying that we have to change the terms that we're using to describe the literal worst people in the world, doing the worst act in the world with the proper term for doing so and fear of you hurting their feelings, if that is the case. And she was being sarcastic. Yeah. It's definitely a distasteful joke. Should she lose her job for a distasteful, sarcastic remark? No, but if she is sitting here in front of a class of high school students protecting pedophiles and telling minors that they should also do the same, right? Literally the people that pedophiles go after minors in this case, um, Now it says that Daniel call vice president of El Paso independent school district board noted that while the lesson plans are approved by administrators, Parker appeared to stray from it in the particular class call had previously offered Parker. The benefit of the doubt saying the video had appeared to omit some important context and that it seemed Parker was only pretending to advocate the position. Now it did seem like she had some tonality there that seemed a little sarcastic, but I'm not gonna be the one to protect her update on my last post, after hearing from some of the students that were in the class, including my own nephew, I believe now that the teacher had appeared to be promoting and normalizing pedophilia was pretend, uh, I believe now that the teacher that appeared to be promoting in normalizing pedophilia was pretending to advocate a position. She didn't actually believe in, in order to challenge the students in preparation for them reading the play, the cruc. The video that many of us saw was missing. The important context. I regret the negative attention that the situation is brought to the teacher and wish her well. I'm told she is a great educator, but he ultimately voted in favor of firing her saying any reasonable person that heard what the seven trustees heard would've voted to terminate Amber Parker. Now Parker's husband. Jason said that Parker's comments were made to challenge students. Mr. Daniel call. I happen. The sick, the sick, what Mr. Daniel call, I happened to be the husband of the teacher in question Parker road on Facebook, I can tell you that we were shaken to our core about these accusations. It is both scary and disturbing that ANED 18. Second clip could destroy a 30 year career when taking completely out of context, she ex is exemplary as a teacher and truly cares about the students. Needless to say, we have spent many sleepless nights because of this cruel release to social media of the 18 seconds. We pray that you and the rest of the board will see this for what it is and not allow the edited video to destroy an innocent woman, her career, and her family in the process. I want to thank you personally for the updated post to begin to write this wrong. So it says that controversial classroom moments have been captured across the country. In recent years, driving parents to school, board meetings, demanding more of a say in their children's education. Um, Let's look at some of the comments here that says, this is a big problem with society, anything, and everything can be manipulated, um, input online or in the media to be the opposite of the actual facts. And once it is out, any correction, um, or apologies are buried and people are left with false impressions of circumstances. Uh, it also says that, um, want to know what's wrong with education today. After speaking with students and witnesses, I have come to believe that the teacher was being satirical and not expressing a view she held, but rather the opposite. I hear she is a great teacher, da, da, um, okay. That doesn't give us much information at all. Um, so it also says, so it is illegal to help a map with a cellulose nitrate and nitroglycerin assisted copper CLA PB projectile traveling at two times the speed of sound striking them with the frontal bone exiting the exci the bone, or is that still murder? Oh, I think that's called a gun.  um, interesting. All right. Anyways, so. This is, this is, this is, you know, good that these headlines are starting to lead in this direction. Right? Good. That we're starting to see pushback from not only the parents going to parent meetings, but also the school boards going in realizing the pushback that they're gonna have in these situations. Now, if this is a case where that teacher was being sarcastic, poor taste, poor timing, let's not even talk to children about the idea of normalizing pedophilia in the classroom. Obviously, you know, not the right way to go about that. Um, but should she be fired for having a sarcastic remark talking about maps? Eh, I don't know. But if she's saying that, you know, the, the sentence alone, maybe you shouldn't be talking about, you know, what did she say? So don't judge people just because they want to have sex for a five year old or with a five year old. Yeah. That's not funny. That's not a joke. That's not sarcasm. That's not that's wrong time and place. If you wanna do that at a bar and played devil's advocate on an argument, you know, you deserve to get ripped apart by whoever you're doing that with. Maybe you don't need to lose your job over it being sarcastic on that note. But in this case, don't talk to children about not judging people who wanna have sex with a five year old. Right. Anyways, now, Again, I think it's a positive thing that this is coming up. I think it's a positive thing that the school board is pushing back immediately. Not waiting for parents to come to school, board meetings, calling an emergency meeting over this because this got millions and millions and millions of views. Um, but anyways, let's go ahead and move on. But before I do that, I need you to do one thing for me. And what I need you to do is if you didn't hit that subscribe button just tipity tap it. There's not very many things you can do in your day to get good karma. It's gonna come back around. I promise you, your day's gonna get better. You're gonna feel just lighter when you move around, you know, when you're going to work, you're on your way to work. Your day's just gonna work out better if you just hit that subscribe button. All right. If you're already subscribed, I appreciate you. So. Hit that five star review button. All right, leave a nice review. Write something in the comment section, whatever it is, write a five star review. Even if it's just five words helps me get up in the rankings, helps more people get the message out on these certain topics and get a normalized view on some of the craziness that is happening in the world. This is not Fox news. This is not CNN. This is just a guy standing here, ball sitting here, um, drinking a little bit of whiskey and talking to you about my opinions. So leave a five star review. Um, again, I appreciate your head over to the website. Red pill, revolution dot C o.com is for losers head over there. Right now you can sign up for subst, which gives you all of the articles, um, all of the videos. And, uh, if you don't see it, check your spam folder. All. Um, anyways, go ahead and head over there right now you can sign up for the subst stack. You'll get all of the articles free to your inbox. You'll get the full video episode, full audio podcast directly in your inbox every single week, every single episode, and the, uh, next episode we're getting, or the one after that is going to be another interview. And I'm really excited about it. So make sure you stick around for that. Go head over there right now. Red pill, revolution.co, and lastly, but not loosely  you are going to die. I'm sorry to be the one to tell you. I'm sorry to be the one to break it to you, but you're gonna die. And when you die, anything that you owe, including your home, your credit card. Your car payments, all of that taxes, all of that's going to be left to your spouse, all of that debt. Then if it's not your spouse, it's your grandchildren. And if it's not your grandchildren, it's your children. And if it's not your children, it might be some random guy that you never met. That is just, you know, Somehow related to you that the government decides to go after. So what you need to do is you need life insurance. And if you don't have life insurance already, when I became a father, I am a father of three beautiful children. And when I became a father, it helped me to realize my mortality. I was never going to die before I had children. At least I never worried about it. Didn't affect me. Right.  because when I die, it's, it's, it's done. It's over. But now I have an extension of my being on this world. I will live on forever to Val hella I go. But when I go, I do not wanna be the one to leave my children with debt. I do not wanna leave my wife with debt, right? I want to leave them a legacy and you can do that by going to red pill, revolution.com, hitting the menu button at the top, left and signing up for some life insurance. You're not gonna get any phone calls. That's the biggest problem with the life insurance industry and the health insurance industry. If you ever dealt with it, it's a pain in the, as it's the worst thing in the world. Whenever you put your number in the. This isn't gonna happen. You can sign up directly online. You don't have to talk to me. You don't have to talk to anybody. All right. We're currently in nine states. If you're not in one of those states, go ahead and send me an email. I will literally get the license just to help you get life insurance. Okay. Send me an email. Austin red pill, revolution.co all would love to help you out. All right, let's move on. But again, head over there right now. Sign up, subscribe. Five star review, everything I just said. Go ahead and do it. I love ya. I love ya. All right, let's move on. The next article that we're gonna discuss here is going to be Ukraine's astronomers. Say that there are tons of UFOs over Kiev during the war with Russia, wild stuff. If you haven't heard about. This is an article from vice and it says Ukraine's airspace has been busy this year. That's the nature of war, but scientists in the country are looking to the skies and seeing something that they even didn't expect. Inordinate number of UFOs, according to a new pre-print paper published by Kiev's main as astronomical observation in coordination with the C's national academy of science. Say that three times fast. Uh, let's try it. Um, Kiev's main astronomical observation.  I said it wrong the first time. Astronomical observa, astronomical observatory in coordination, astronomical observatory in coordination with the country's national academic. Society of science. The paper does not specifically address the war, but in the United States, the Pentagon has long hinted, speculated and warned that some UFOs could be advanced technology from foreign military, specifically China and Russia, though. It hasn't been really given any evidence that this is actually the case. The Ukraine's paper is particularly notable because it is not showing that science has continued to, uh, to occur during this war, but also explains that there has been a lot, a lot of sightings. We see them everywhere. The researcher said we observe a significant number of objects whose nature is not clear. The paper is titled unidentified, aerial phenomenon, one observations and events come from observations made by NAS main astronomical observatory in Kiev, in a village south of Kiev called VIN. RKA. According to the papers authors, the observator took on the job of hunting for UFOs as an independent project because of the enthusiasm around the subject. Yeah. Interested. You got my interest. It goes on to say that it describes a specific type of UFO. The researchers call Phantoms. That is an object that is completely black body that does not emit and absorbs all of the radiation falling on it. The researchers also observed that the UFOs that seeing are so fast that it's even hard to take pictures of them. The eye does not fix phenomenon lasting less than one 10th of a second. The paper said it takes four tenths of a second to recognize an event. Ordinary photo and video recordings will also not even capture. The UAPs to detect UAPs. You need a to fine tune, the equipment, shutter speed frame rate, and dynamic range. Wow. So video cameras, recordings, photos, and even your eyes cannot see the UFOs that are flying across Kiev right now. And there's an astonishing number of them. It says wild. So the researchers did just that using two media monitoring stations in Kiev, in Veka, we have developed a special observation technique taking into account the high speeds of the observed objects. The paper said the exposure time was chosen so that the image of the object did not shift significantly. During ex exposure. The frame rate was chosen to take into account the speed of the object in the field of view of the camera in practice. The exposure time was less than one millisecond and the frame rate was no less than 50 Herz. Not sure what that means. Not a photographer. The scientist divided the phenomenon they observed with two into two different categories. Cosmics and PTO. We note that cosmics are luminous objects brighter than the background of the sky. We call these ships names of birds, swift Falcon, and Eagle. The paper said Phantoms are dark objects with contrast from several to about 50% says using camera stationed, roughly 75 miles apart allowed the scientist to make repeated observations of strange objects. Moving in the sky. The paper did not speculate on what the objects were. Merely noted the observations and mentioned the objects. Incredible speeds. They went on to say that flights of single group and squadrons of ships were detected. Moving at speeds from three to 15 degrees per second, Phantoms were observed in the troposphere at distances of up to 10 to 12 kilometers. We estimate their size from three to 12 meters and speeds up to 15 kilometers per second. Wow. 15 kilometers per second. If you break that down is something like, I don't know. It's like 1.8 to times, something like that. I don't know. So it's basically like nine miles per second. That math is probably terribly off. And I'm so sorry if you're somebody who goes by the metric system, I am not. So just trying to help you guys out  it says the easy explanation would be that these are missiles or rockets or something else associated with the war. But the scientists insist that their nature is not clear. UFOs are back in the public conscious. After a string of sightings were caught on camera by Navy pilots. Congress has demanded answers and the Pentagon responded by saying this is seen, that has seen some strange stuff, but needed more time and money of course, to, because they don't have enough money to send to Ukraine and also look into potential, you know, UFOs entering our airspace with alien beings inside of them. At the same time  to study the phenomenon appropriately. Congress gave them both. And the Pentagon open to the a, a R O oh, the a a R O is that we talked about this about a week or two weeks ago where the Pentagon basically opened an entire subdivision section specifically to study this phenomenon of alien UFOs, not, not potentially, you know, China and Russia, uh, military aircraft, they already sub sectioned off the potential of that. Right. They said that we believe that some of these are not of human origin. They defy the laws of physics as we know them. Okay. Wild, wild stuff. And they're starting to come out and talk more about. All right. The article goes on to say, um, a recent addendum in the Senate intelligence budget report said that the thread of UFOs was increasing exponentially and that the Pentagon's new office needed to focus on the UFOs that aren't manmade. Yep, exactly what we just talked about and exactly what we talked about a few episodes ago. So go ahead and listen to that one. When you're done with this one, um, Boris, the lead researcher of the paper declined to comment. This says that there's an update from nine 13, which is yesterday says the original version of this article stated that the Kiev study was a joint venture with the Pentagon and NASA. It was not vice has corrected the story and regrets this era. Wow, good on you. Vice way to go way to go. Now, one thing that, you know, speaking of corrections, there's been a lot of articles recently talking about how IRA Mein was allegedly put in. I think it was the CDC or the who said that IRA Mein is now an allowable substance when it comes to COVID and has helped significantly. Now, um, the correction that was made was basically that they are still not recommending it. They still want to do trials. That was the big correction that a lot of people made. Um, but they're saying that it's potential. Hmm. Um, but there's been a few people like Russell brand came out and made like an apology statement. Um, Russell brand's the actor. Awesome dude. One of my favorite favorite podcasts. I've like tried to categorize myself as a podcast and I'm like, I don't want to technically be Tucker Carlson. I don't want to technically be a political podcast. I want to be more like there's one person I can put myself in a category with. That's like kind of a mixture of like libertarian politics, not left or right. Mainstream narratives also kind of conspiracy based with a touch and little bit of like globalism pushback  and some good humor. Hopefully you think so. Um, it's Russell brand Russell. Brand's got a great thing going, if you haven't listened to his podcast, go check it out. It's definitely, uh, a bit on the same genre and topics that we discuss here. Pretty interesting stuff. A mix of politics, current events, pop culture, and a little bit of conspiracy stuff. If you know what I mean. All right. Now, Um, pretty wild stuff. The, the, the UFO situation is just wild to me. You know, there's been so many conversations, so many articles, so many, you know, governmental institutions that are pouring money into this now that are saying, and making this conversation mainstream, you cannot ignore it at this point, right. Whether they're pushing an agenda or not, because for how long they've known this stuff's going on, right. From Roswell to, you know, literally, um, who's the guy that went on to Joe Rogan. Um, uh, gosh, I blanking on the name. Um, but there's been so many people that have come out and said that they were a part of this, uh, you know, from anything from seeing UFO Aircrafts, you know, how long have those sightings been going on? Uh, Jeremy Corbe was the guy I'm thinking of. Um, and he basically is one of the most, uh, mainstream people talking about this. He's had so many good conversations, really good, uh, footage that he's caught on it, um, breaks down these things very, very well. Um, so. If you haven't heard that go listen to the Jeremy Corbe podcast, uh, with Joe Rogan, it it's quite quite interesting. Um, and he even talks to somebody else who claims to have been a part of it at Roswell. So that's pretty wild too. Um, and that was with, uh, who, what is that other guy's name? Of course I'm like, just trying to think of names that of people I can't recall. Um, but it's pretty crazy. He like says that he basically went in and saw the UFOs, saw the, um, saw Bob Laar is a whole documentary on it. Bob Laars documentary by Jeremy Corbe and they go into how he was literally taken by. It was like the, um, by the military, by the CIA or whoever was conducting these operations. And because he was like in the newspaper for building rocketships  and so, um, he, they, he basically went into, um, area 51. And said that he saw the ships, he saw, literally believed that he said saw aliens. It was like years and years ago, but he said that he saw them, um, in, in, so there's, uh, all of these things that came out, like the chemicals that they, the chemical compounds that he talked about prior to the government even saying they existed. So there's all these really weird correlations and all of these things. And Bob Laar is a very interesting character. Um, he doesn't seem to want a ton of attention off of it. He seems to just be like, he, he legitimately seems to be telling the truth. Um, it's a very interesting conversation. Go look up that documentary too, giving you lots of homework assignments today. Sorry. um, so, um, then we'll go ahead and talk about this in just a moment, which is the, the China situation with moon chemicals or. Nuclear fusion stuff. But one thing I did wanna show is that, you know, apparently Dr. Fauci, Dr. Fauci, Mr. Science himself is getting still grilled by Ram Paul, which I love. And you'll see in this clip, he's literally shaking due to this conversation. So let's go ahead and watch this Ram Paul article take a little bit of a shift from the alien stuff, um, which would kind of have been a nice segue into China going to the moon and finding this, but let's, let's, let's stop that segue. And let's go ahead and look at this. Yeah, actually, you know what, let's talk about it. if you have not heard China discovered a stunning crystal on the moon, which they believe could give us unlimited energy of nuclear fusion fuel. Now this article is by vice and it says that the find makes China the third country to discovery a new mineral on the moon. And the country says it's analyzed the soil for rail rare helium three. Interesting. It says that China has discovered a crystal from the moon made of a previously unknown mineral while also confirming that the lunar surface contains a key ingredient for nuclear FIS vision, a potential form of effective or effectively limitless power that harnesses the same forces that fuel the sun and other stars. The crystal was a part of a batch of lunar samples collected by China's change five mission, which landed on the moon in 2020 loaded up with about four pounds of rocks and delivered them to earth days later, each carefully sifting through the samples, which are now the first moon rocks returned to earth since 1976. If you believe that scientists at the Beijing research Institute of uranium, geology spotted a single crystal particle with a diameter smaller than the width of a human hair, the crystal is made of a novel mineral Chan change site. Named after the Chinese moon goddess change or changey, I don't know how you pronounce that. There's a hyphen between C H a N G and then the hyphen, and then E it also inspired China's series of lunar missions. It is confirmed that as a new mineral on Friday by the commission of new minerals, it's a weird commission, um, nomenclature in classification, which is, uh, brought down to C N M N C  of international mur neurological association. According to the Chinese state run publication. Global times change site is the sixth new mineral to be identified in moon samples. And the first to be discovered by China before China, only the us in Russia could claim to have discovered a moon, moon mineral. It is a transparent crystal that formed in a region of these Northern lunar nor near face. That is volcanically active about 1.2 billion years ago. Um, let's see what this article continues to say, which is according to the state media, the new lunar samples also contain helium three, a new version of the element helium that has long fascinated scientists and science fiction creators because of its potential as a nuclear FIS vision fuel source, the hypothetical form of power aims to harness energy released by atoms that merge under tremendous pressure, such as those in the interior of stars. Starlight is a ubiquitous product of nuclear fusion, but human made fusion reactors will still likely take decades to develop assuming that they are fusible at all that sad. If these reactors do become a reality, helium three would be a good fuel candidate because it produces less radioactive byproducts and nuclear waste compared to other atoms. Whereas helium three is incredibly scarce on earth. It is abundant on the moon, a disparity that has stoked dreams of mining the minerals on the lunar surface. Along those lines, China has joined the United States and other nations and expressing interest in extracting resources from the moon. In the future. Very, very interesting. Now, a couple article titles that I'll go through here, and I'm not gonna dive deep into these articles, but I just want you to know them. It says that China is planning to turn the moon into a giant space shield sounds like some star war shit. Um,  uh, and another one is also, um, space junk, crashing all over the world, upsetting everyone. You know, I, I'm not that upset about space junk. Haven't heard about it much other than the fact that it's an unbelievable amount of space junk surrounding our earth. If you haven't heard about that, there's literally, there's a, I'm pretty sure there's a, a map that you can look at of the earth. And it shows all of the space junk, which is like little things that we've sent up in pieces of, uh, satellites and things like that. Like when they're done with a satellite, they're done using it, all of the satellites we've ever put up there, they just leave them there. Even if they break down, even if there's things that go on with them, um, pretty, pretty wild stuff. Like they almost be like the, when they go to plan a mission. To go into space. Oh, allegedly. Um,  when they go to plan the mission, they do math calculations because they track all of the space junk and try to figure out. How, what timing of day based on the trajectory, the speed of the, uh, the speed of the rocket or whatever, um, to try and make it. So it does not hit space junk because even if it hits a marble size of space, junk going 35,000 million miles an hour, however fast they go, it's going to destroy, destroy the, um, destroy the ship. So they have to calculate it based on the timing. And there's so, so much junk in space, um, that it's very difficult for them to time. Um, another article here from this is from a little while ago, it says Mars formation that looks like alien doorway spotted by NASA Rover. How do we not hear about this stuff? There's so much wild things going on in the world today that it's. I, I am so under the idea  this is a simulation, the simulation theory is so interesting to me because what is the likelihood there was like literally horse and buggies, like a hundred years ago, right? 1922 people were literally riding horses almost. And now just so it happens to be the timing that we're alive, that we get to see the most interesting technological booms ever. Right. You wanna go back and talk, you know, and it's like a hundred years ago is literally your great grandparents. Your great grandparents were alive a hundred years ago for sure. A hundred years ago, right? Maybe, maybe not maybe your great-great grandparents, but maybe your great grandparents, depending on how old you are. Um, and maybe your parents even right. A hundred years is not that long ago. Right. And 500 years is not that long ago, either 500 years ago is literally your great, great, great, great, great grandparents. That means five people had sex and now you're here  and all of a sudden we went from all living like the Amish or the Indians. And all of the sudden, since the 15 hundreds, we are looking at space formations, nuclear, fission rocks, talking about aliens, visiting us. I'm literally speaking to you through a plastic piece of, uh, you know, bullshit that nobody know how knows exactly how it works. You know, it's like, it's so wild that we live here today in this reality on this timeline that it just seems so unprobable to me, I just don't get it. There's, there's literally no way.  the likelihood that I am not a Amish person on a farm, you know, 1500, you know, and even the fact of like 2000 years ago,  being that far again, that's not that far. That's literally not that far. Not that far. Right? 25, 30, 30 sexes ago.  that's gonna be the way that I, I, I think of time now is how many people had to have sex between now and then for you to be in that era 30 sexes ago, you could have been living in a. The same time as Jesus. And now they want to tell us that like, you know, literally the worth was the earth was, you know, however many, you know, years old. It's like, nah, I don't believe ya. I don't believe ya. I don't think so. There was an article that came out there was like 30,000. Um, they found the body that, you know, was kind of disputing all science on humanities, you know, uh, timeline. It was like 30,000 years old or even, maybe even longer than that. But there's some really interesting scientific articles and things that have come out that, that even say that it's longer than that. Right. That, that say that the pyramids were really from like there's, there's all of the sentiment that's been eroded underneath. Like there's like pyramids under the pyramids that are coming. and, uh, they they're like challenging all of the science, all of their religious beliefs. All of the things that we talk about today is being the timeline of humanity, right. It it's, it's pretty wild stuff. Um, and, and it's something they'd be interested in because, you know, we even go back into the conversation from yesterday of like the, or yesterday of last week and the queen and the reptilian species. it's so funny how easily you can jump into reptilian, Illuminati, reptiles, uh, controlling the world. Um, but there's like this whole idea of the Sumerians and the Sumerians being visited. And the Sumerians are like one of the very first humanity, like, uh, very first peoples, um, that humanity believed existed and the Sumerian race being visited and given technology that, that we can't even comprehend today. The, the ancient Sumerian societies had mathematical equations to map out the cosmos and, and like, let me look up the timeline of like, when, um, the Sumerian, uh, We're even around, um, because it's, it's so wild when you look up the actual history of, of ancient Sumeria. Um, this says it was like 2,350 BC. So 4,005,000 years ago, um, in Sumer, uh, the Sumerians were people of Southern Mesopotamia whose civilization flourished between 4,100 to 1750 BC. So six, 7,000 years ago, um, like the ancient Sumerian technology let's, you know, let's, let's dive into it. I got a little bit of whiskey left. Let's dive into the ancient Sumerian technology.  we, we might as well, let's see if I can find it. Um, let's see, ancient Sumerian technology. And if you're still here with me, I appreciate ya. This is fun. Let's do it. Ancient Sumerian technology. Um, let's go ahead and see what, uh, is questionable. Let's see what we can find here. So a few of the articles that are coming up is ancient Sumerian technology, nine ancient Sumerian tech, uh, inventions that changed the world. Um, let's see, there's like photo there's like hieroglyphics of the Sumerians with, you know, weird technology and seeing like, um, Kymera reptiles and, and different beings and g

After the Delian Leagues victory over the Persian forces at the Eurymedon River, campaigning would continue with it appearing other areas closer to the Greek mainland being the focus. Though, the Island of Thasos, an original Delian league member would now also revolt from the league, seeing Athens and the leagues attention being refocused to deal with this developing threat.We are told that the revolt would come about due to economic reasons, with Athenian influence now also extending into areas Thasos had control in. This would see the full force of Athens navy and by extension the Delian league directed at the island in the Northern Aegean. Thasos would be laid siege to and would now attempt to seek assistance from outside of the Delian league.Here we can perhaps see the path to conflict between Athens and Sparta, since Sparta would be the city Thasos would turn to. Sparta, with it seeming the war party had now gained more influence within Spartan politics, in turn would secretly agree to attack Athenian territory to try and relive the siege directed at the island. This being the first overtly hostile action we hear of being contemplated.Though, Poseidon, the earth shaker would see to it that the attack would not take place. A great and terrible earthquake would rock the Peloponnese seeing many cities including Sparta devastated. This would create further issues for Sparta to deal with, while the path to conflict between Athens and Sparta would be further laid as the consequences from this event unfolded.   Support the show

Where It Happens ✓ Claim Podcast Notes Key Takeaways  Think of crafting an early-stage startup like you'd create a movieWrite the script ahead of time, identify and place the ideal profiles in the appropriate roles, lock everyone in a room for six to twelve months, forge product-market fit, and emerge with the productAll other variables held constant, an in-person startup will beat out a remote startup The best way to level the playing field is through our republic democracy via votes and policy; early-stage startups should not be forced to be the catalyst for implementing political change “The person that is likely going to contribute the most to climate change is going to look like a heavily capitalist, venture-backed, private startup, and not through some global, large, public policy.” – Delian AsparouhovA material percentage of the Environment, Social, and Corporate Governance (ESG) groups in the United States are funded by Russia and China; they are not acting in the best interests of the United States The Chinese Communist Party operates on multi-decade time horizons; the recent, tragic developments in the United States are not by accident Almost all of the best innovations in history came from cross-pollination, oftentimes unexpected cross-pollination, from two completely different fields consisting of top-tier, multi-disciplinary, physically co-located people working incredibly hard and incredibly smart on separate things Organic, spontaneous connections between unrelated disciplines do not happen if you're working entirely remote Delian's company, Varda Space Industries, will manufacture high-quality materials in low-orbit and then bring those materials back down to earthManufacturing products such as pharmaceuticals and human organs in zero-gravity space has certain advantages over manufacturing them on EarthRead the full notes @ podcastnotes.orgAre you stuck creating on the couch? In today's episode, we explain how one small group can change the world, debate whether these people need to meet in real life, and Delian shares why he feels start-ups must hire based on merit. Hosts Sahil Bloom and Greg Isenberg are joined by guest Delian Asparouhov, principal at the Founders Fund and co-founder of Varda. Delian explains the secret to running a billion-dollar fund while simultaneously launching his first company, shares his take on where the venture world is headed and explains how China is taking control with TikTok. ►► Want more community? Learn more here: http://trwih.com SPECIAL THANKS TO OUR SPONSOR ►► This episode is brought to you by Wealthfront, a saving and investing app that can help you earn more on your money and build wealth for your future. The Wealthfront Cash Account grows your savings at 1.40% APY, and offers unlimited, fee-free transfers to your external accounts — plus, a ton of other features that help you optimize your cash. So, if your money is earning less anywhere else, now might be a good time to make a move. Wealthfront is offering Where it Happens listeners a free $50 bonus with a $500 initial deposit to a new Cash Account. Go to wealthfront.com/Happens to claim your $50 and start growing your savings. Cash account is offered by Wealthfront Brokerage LLC, Member of FINRA/SIPC. Wealthfront Brokerage is not a bank. We convey funds to partner banks who accept and maintain deposits, provide the interest rate, and provide FDIC insurance. Rate is subject to change. Investment management and advisory services--which are not FDIC insured--are provided by Wealthfront Advisers LLC (“Wealthfront Advisers”), an SEC-registered investment adviser. THIS EPISODE Delian Asparouhov: https://twitter.com/zebulgar Sahil Bloom: https://twitter.com/SahilBloom Greg Isenberg: https://twitter.com/gregisenberg Production & Marketing Team: https://penname.co/ FIND US ON SOCIAL Twitter: https://twitter.com/_trwih Instagram: https://www.instagram.com/_trwih Web: https://trwih.com Spotify: https://open.spotify.com/show/6aB0v6amo3a8hgTCjlTlvh Apple: https://podcasts.apple.com/us/podcast/where-it-happens/id1593424985 SHOW NOTES 00:00 Sneak Peek 01:11 Welcoming Delian 02:23 How a Small Group Can Change the World 07:54 Hiring Based on Merit 10:14 Did ESG Create Change? 13:40 TikTok Data Rights 17:36 You Can't Change the World from Your Couch 21:55 Greg's Unique Perspective On Working Hard and a 10-Year Bet 28:33 What is Varda and its Origin Story? 37:31 Separating Design (+) Manufacturing = Innovation 42:51 How to Become a Leader and Expert in Space 45:34 The Secret to Founding a Start-Up and Running a Fund 50:48 Delian's Origin Story and His Prediction for the Future 56:04 Thanks for Listening

Where It Happens ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Are you stuck creating on the couch? In today's episode, we explain how one small group can change the world, debate whether these people need to meet in real life, and Delian shares why he feels start-ups must hire based on merit. Hosts Sahil Bloom and Greg Isenberg are joined by guest Delian Asparouhov, principal at the Founders Fund and co-founder of Varda. Delian explains the secret to running a billion-dollar fund while simultaneously launching his first company, shares his take on where the venture world is headed and explains how China is taking control with TikTok. ►► Want more community? Learn more here: http://trwih.com SPECIAL THANKS TO OUR SPONSOR ►► This episode is brought to you by Wealthfront, a saving and investing app that can help you earn more on your money and build wealth for your future. The Wealthfront Cash Account grows your savings at 1.40% APY, and offers unlimited, fee-free transfers to your external accounts — plus, a ton of other features that help you optimize your cash. So, if your money is earning less anywhere else, now might be a good time to make a move. Wealthfront is offering Where it Happens listeners a free $50 bonus with a $500 initial deposit to a new Cash Account. Go to wealthfront.com/Happens to claim your $50 and start growing your savings. Cash account is offered by Wealthfront Brokerage LLC, Member of FINRA/SIPC. Wealthfront Brokerage is not a bank. We convey funds to partner banks who accept and maintain deposits, provide the interest rate, and provide FDIC insurance. Rate is subject to change. Investment management and advisory services--which are not FDIC insured--are provided by Wealthfront Advisers LLC (“Wealthfront Advisers”), an SEC-registered investment adviser. THIS EPISODE Delian Asparouhov: https://twitter.com/zebulgar Sahil Bloom: https://twitter.com/SahilBloom Greg Isenberg: https://twitter.com/gregisenberg Production & Marketing Team: https://penname.co/ FIND US ON SOCIAL Twitter: https://twitter.com/_trwih Instagram: https://www.instagram.com/_trwih Web: https://trwih.com Spotify: https://open.spotify.com/show/6aB0v6amo3a8hgTCjlTlvh Apple: https://podcasts.apple.com/us/podcast/where-it-happens/id1593424985 SHOW NOTES 00:00 Sneak Peek 01:11 Welcoming Delian 02:23 How a Small Group Can Change the World 07:54 Hiring Based on Merit 10:14 Did ESG Create Change? 13:40 TikTok Data Rights 17:36 You Can't Change the World from Your Couch 21:55 Greg's Unique Perspective On Working Hard and a 10-Year Bet 28:33 What is Varda and its Origin Story? 37:31 Separating Design (+) Manufacturing = Innovation 42:51 How to Become a Leader and Expert in Space 45:34 The Secret to Founding a Start-Up and Running a Fund 50:48 Delian's Origin Story and His Prediction for the Future 56:04 Thanks for Listening

Are you stuck creating on the couch? In today's episode, we explain how one small group can change the world, debate whether these people need to meet in real life, and Delian shares why he feels start-ups must hire based on merit. Hosts Sahil Bloom and Greg Isenberg are joined by guest Delian Asparouhov, principal at the Founders Fund and co-founder of Varda. Delian explains the secret to running a billion-dollar fund while simultaneously launching his first company, shares his take on where the venture world is headed and explains how China is taking control with TikTok. ►► Want more community? Learn more here: http://trwih.com SPECIAL THANKS TO OUR SPONSOR ►► This episode is brought to you by Wealthfront, a saving and investing app that can help you earn more on your money and build wealth for your future. The Wealthfront Cash Account grows your savings at 1.40% APY, and offers unlimited, fee-free transfers to your external accounts — plus, a ton of other features that help you optimize your cash. So, if your money is earning less anywhere else, now might be a good time to make a move. Wealthfront is offering Where it Happens listeners a free $50 bonus with a $500 initial deposit to a new Cash Account. Go to wealthfront.com/Happens to claim your $50 and start growing your savings. Cash account is offered by Wealthfront Brokerage LLC, Member of FINRA/SIPC. Wealthfront Brokerage is not a bank. We convey funds to partner banks who accept and maintain deposits, provide the interest rate, and provide FDIC insurance. Rate is subject to change. Investment management and advisory services--which are not FDIC insured--are provided by Wealthfront Advisers LLC (“Wealthfront Advisers”), an SEC-registered investment adviser. THIS EPISODE Delian Asparouhov: https://twitter.com/zebulgar Sahil Bloom: https://twitter.com/SahilBloom Greg Isenberg: https://twitter.com/gregisenberg Production & Marketing Team: https://penname.co/ FIND US ON SOCIAL Twitter: https://twitter.com/_trwih Instagram: https://www.instagram.com/_trwih Web: https://trwih.com Spotify: https://open.spotify.com/show/6aB0v6amo3a8hgTCjlTlvh Apple: https://podcasts.apple.com/us/podcast/where-it-happens/id1593424985 SHOW NOTES 00:00 Sneak Peek 01:11 Welcoming Delian 02:23 How a Small Group Can Change the World 07:54 Hiring Based on Merit 10:14 Did ESG Create Change? 13:40 TikTok Data Rights 17:36 You Can't Change the World from Your Couch 21:55 Greg's Unique Perspective On Working Hard and a 10-Year Bet 28:33 What is Varda and its Origin Story? 37:31 Separating Design (+) Manufacturing = Innovation 42:51 How to Become a Leader and Expert in Space 45:34 The Secret to Founding a Start-Up and Running a Fund 50:48 Delian's Origin Story and His Prediction for the Future 56:04 Thanks for Listening

With the victory over the Persian invasions in 479 BC, the Greeks had continued operations in the Aegean against Persian controlled areas. Though, objectives and priorities of many of the city states had shifted with this common threat ejected from Greek lands. This would see yet another league formed, that of the Delian league, who would continue campaigning throughout the Aegean. While these campaigns continued on for the next 10 years, political developments within the Greek mainland would evolve with the new reality. The Persian threat had united the many Greek city states, putting their suspicions and interests in the background. Now though, what had united them had been defeated and these interests and suspicions would once again come to the forefront.Both Athens and Sparta would now attempt to establish a policy that would suit their cities in the post war period. Though, both polies would have a number of paths open to them with different factions within their political systems competing for their preferred path. As events unfolded over the next decade both city states would eventually settle on a policy.This period would see the hero of Salamis, Themistocles ostracised, freeing the way for his opponents in Athens. While Sparta would be contending with regions on the Peloponnese growing in influence with the rise of democratic factions within them. This forcing them to bring their focus back closer back to their home region. Though, these developments would be seen to be connected as the various factions manoeuvred for political advantage. Support the show

Heidi and Ellen talk to Delian and Erica. Delian is currently an actor. She worries the path she is pursuing is frivolous and feels that she needs to be moving faster and doing more. She worries that she is not going to do what she is supposed to with her life (10:09).  Erica works in human resources at a big tech company. For the past two years, she has felt a deep ache and unfulfilled with her work. She wants to think, speak, and contribute differently to the world and cannot seem to find the right path to step onto (20:01). Heidi and Ellen also talk about the movie Marcel the Shell with Shoes On (1:34); the television series Gaslit (5:27); The Bear (6:08); and the book We Should All Be Millionaires by Rachel Rodgers (7:02). 

“Hubris kills startups and humility saves them. No matter what your success level is or may not be, it's really important to always be humble about what you're building and what you're doing because it can change at the drop of a hat.” – Mo Islam Mo Islam is co-founder of Payload, which is building a media empire dedicated to covering the business and policy of space, as in outer space. We discovered Payload and immediately subscribed to their daily newsletter after it was recommended by Delian Asparouhov, co-founder of Varda Space Industries, in Episode 71. We asked Delian what newsletters and websites he used to stay on top of everything going on in space, and he had only one answer: Payload Space. Mo Islam has a fascinating background in finance, having worked at J.P. Morgan and Deutsche Bank before co-founding Payload. In this episode, Mo shares why hubris kills startups and humility saves them, what he's learned from incredible investors like Philippe Laffont at Coatue, and why he loves the book Engines That Move Markets, which we had never heard of but immediately ordered after recording this episode with him. Show notes with links, quotes, and a transcript of the episode:  https://www.danielscrivner.com/notes/mo-islam-playbook  Chapters In this episode, we deconstruct Mo Islam's peak performance playbook—from their favorite book to the tiny habit that's had the biggest impact on their life. In it we cover: 00:00:00 – Introduction 00:01:40 – Clearing up misconceptions about space 00:03:06 – Kill them with kindness, embrace the boredom 00:05:30 – Learning from Phillippe Laffont and Engines That Move Markets 00:07:33 – Hubris kills startups; humility saves them 00:09:18 – Focus on what you love 00:12:02 – Learning from the Apollo era 00:13:15 – Relying on to-do lists and the Notes app 00:15:53 – Do what matters, change people's lives for the better Sign up here for Outlier Debrief, our weekly newsletter that highlights the latest episode, expands on important business and investing concepts, and contains the best of what we read each week. Follow Outlier Academy on Twitter: https://twitter.com/outlieracademy. If you loved this episode, please share a quick review on Apple Podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices

“Very simply, we are living in the next space race, and it's going to have huge implications for the way we built technology, the way we spend dollars in military.” – Mo Islam Mo Islam is the co-founder of Payload Space, which is building a media empire dedicated to covering the business and policy of space, as in outer space. We discovered Payload and immediately subscribed to their daily newsletter after it was recommended by Delian Asparouhov, co-founder of Varda Space Industries, in episode 71. We asked Delian what newsletters and websites he used to stay on top of everything going on in space, and he had only one answer: Payload Space.  In this episode, we go deep on why we're at an inflection point when it comes to space and how that was unlocked, at least in the U.S., largely by SpaceX, which has brought down the price to get a unit of mass up to low Earth orbit by order of magnitude. We cover the outsized role the military and defense departments play as customers for space companies, ranging from Earth imaging to satellite manufacturing startups. We talk about the space companies that Mo thinks are the most underrated, as well as how Payload is building a media empire, starting with what Mo calls The Modern Homepage, which is their daily newsletter. We discuss how Payload crafted a compelling voice and editorial style in an old school and relatively stodgy industry, making space cool to read and learn about. Show notes with links, quotes, and a transcript of the episode:  https://www.danielscrivner.com/notes/payload-mo-islam  Chapters This episode is our definitive guide to building a media brand to cover the business and policy of space. In it we cover: 00:00:00 – Introduction 00:02:36 – How Payload focuses on the business and policy of space 00:10:54 – How Elon Musk has changed the space race 00:15:17 – Aerospace and defense go hand in hand 00:18:11 – Earth imaging illuminates the atrocities of war 00:19:36 – We are living in the next space race 00:22:52 – SPACs and space 00:28:57 – How we'll move from government to commercial spending in space 00:33:11 – Reusable second stages and lowering the costs of space exploration 00:36:59 – What scaling Starlink could mean for space travel 00:39:40 – Launching a media brand and the importance of voice 00:43:32 – Making Payload the most important voice in the space discussion 00:51:49 – Learning from feedback and embracing boredom Sign up here for Outlier Debrief, our weekly newsletter that highlights the latest episode, expands on important business and investing concepts, and contains the best of what we read each week. Follow Outlier Academy on Twitter: https://twitter.com/outlieracademy. If you loved this episode, please share a quick review on Apple Podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Delian league had now been established with the majority of its members coming from regions throughout the Aegean. In its inception they had all turned to a Greek city state on the mainland, that of Athens who headed the league. In 477 BC the league would now find itself in a position to begin campaigning for the first time, they would set out under the leadership of a relative new comer to the scene of Athenian politics, Cimon.Thucydides would give us a picture of how the league would evolve over its first decade in operation, as well as highlighting how Athens's power would grow. The league would first direct itself against Persian controlled regions on the Thracian coast, aligned with the objectives it had been created under. Though, it wouldn't be only the Persians that the Delian league would focus its attentions against. Other Greeks would find themselves becoming the target of the league's activities in the Aegean. These actions would be justified for a number of reasons, from eliminating piracy in the Aegean, to protecting the common strategic security through cohesion.As the years passed new challenges within the league would arise. With very little Persian activity in the Aegean league members would have been starting to wonder if the finical costs of supporting the league were in their interests anymore. One member Naxos would act on this and attempt to leave, but this risked seeing the league fall apart. Athens would see that they would remain a member through force. This was an ominous sign of the direction the league was heading in, though the Persian threat had not disappeared just yet. Support the show

In this episode, we talk with Delian Asparouhov, principal at Founders Fund, about Keynesian beauty contest, who should become a founder, removing bottlenecks to successful companies, how to encourage more agency and more.  

Birth of the Delian League:Leagues in Greece were not a new concept, with many being in existence in one form or another. So, far the major leagues that we have followed have been the Peloponnesian league and the Hellenic league, with both of these still in operation by 477BC. These were primarily defensive in nature and were formed around city states that had shared interests or a common foe. Though, what would happen once interests were conflicted or a threat had been extinguished?In 478/477 Athens would find herself in this position now that Persian had been ejected from Greek lands and campaigning had moved into the eastern Aegean. For Sparta and the Peloponnesians, campaigning could begin to wind down with the threat now far away from their lands. Though Athens and the new eastern Greek members of the league saw the threat still present to their interests in Anatolia. This time interests were far more divided than they were in the disagreements before Salamis and Plataea.We are told the various Ionian and other eastern Greeks would unite together in the face of the harsh treatment by Pausanias and the Spartan commanders. They would approach Athens with support to take control of the leadership, eventually leaving Sparta no alternative with all of the other Peloponnesians having returned home. Though, how involved was Athens in ensuring this support would be fostered towards them and their bid on the leadership?What would eventuate though, with the new circumstances and realities would look very different to the framework and objectives of the Hellenic league. What Athens and the eastern Greeks now recognised, was that they have created something new, with differing goals and objectives. This new group of city states would end up holding their first congress on Delos, establishing the mechanisms and objectives of the league. Today we call this league the Delian league and it would be the beginning of future events that would unfold in the Aegean that would be so influential to the area of the Classical Age in Greece.  This episodes podcast recommendation: Warlords of History Podcast Support the show

Delian Asparouhov (@zebulgar), co-founder of Varda Space Industries and principal at Founders Fund, joins Lucas Bagno (@lucasbagnocv) and Ian Cinnamon (@iancinnammon) on this episode to discuss:- Why he says that VCs have a moral obligation to fund companies that help keep America a step ahead of its adversaries.- Why space matters for him personally and why expanding the economic bounds of humankind is the best way to achieve all of humanity's other goals.- The current state of the space economy and the space supply chain, and how he sees them evolving in the future.- Why the US is in a new space race with Russia and China.- His advice on building a space company for aspiring founders.Thanks for listening — if you like what you hear, please review us on your favorite podcast platform. Check us out on the web at www.villageglobal.vc or get in touch with us on Twitter @villageglobal.Want to get updates from us? Subscribe to get a peek inside the Village. We'll send you reading recommendations, exclusive event invites, and commentary on the latest happenings in Silicon Valley. www.villageglobal.vc/signup

Grab a seat on the front row of the race to monetize space. Chris Power and Delian Asparouhov are creating innovative solutions to the problem of space tech manufacturing. Manufacturing is a broken system, with long lead times, fluctuating prices and technology that hasn't kept up. For space tech manufacturing this problem is even more intense, with many systems left over from the first space race in the Sixties, Joe talks to Chris and Delian about how Hadrian is creating its own manufacturing vertical from scratch, why a user-dashboard is not a great bandaid over an existing problem, and why building trust with customers is top of the list. You'll hear Chris talk about why they'll be a base on the moon within the next decade and why the tech supply chain needs to turn on a dime to meet customer needs. Chris and Delian also discuss how they're building a factory from the ground up, and how Delian raised $9.5million in VC investment. Follow Chris: LinkedIn: http://linkedin.com/in/powerc (linkedin.com/in/powerc) Follow Delian: LinkedIn: https://www.linkedin.com/in/delian-asparouhov-87447742 (linkedin.com/in/delian-asparouhov-87447742) Check out the Just Raised newsletter: https://bit.ly/3Ghj2tY Stay up-to-date on all things Just Raised: https://workweek.com/brand/just-raised/ or follow Joe Sweeny on Twitter: https://twitter.com/JoeySweeny (https://twitter.com/JoeySweeny)

On this episode of the #MiamiTech Pod, Delian, Cesar, Maria, and Brian discuss:- Delian's background- What he's up to at Varda Space Industries- The famous tweet heard round the world- Thoughts on #MiamiTech- What he looks for in companies- and moreFollow Delian on Twitter: https://twitter.com/zebulgar